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Aliases for R3HDM1 Gene

Aliases for R3HDM1 Gene

  • R3H Domain Containing 1 2 3
  • R3H Domain (Binds Single-Stranded Nucleic Acids) Containing 2 3
  • R3HDM 3 4
  • R3H Domain-Containing Protein 1 3
  • KIAA0029 4

External Ids for R3HDM1 Gene

Previous HGNC Symbols for R3HDM1 Gene

  • R3HDM

Previous GeneCards Identifiers for R3HDM1 Gene

  • GC02P136123
  • GC02P136005
  • GC02P136289
  • GC02P128281

Summaries for R3HDM1 Gene

GeneCards Summary for R3HDM1 Gene

R3HDM1 (R3H Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is R3HDM2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for R3HDM1 Gene

Genomics for R3HDM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for R3HDM1 Gene

Start:
135,531,455 bp from pter
End:
135,725,270 bp from pter
Size:
193,816 bases
Orientation:
Plus strand

Genomic View for R3HDM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for R3HDM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for R3HDM1 Gene

Proteins for R3HDM1 Gene

  • Protein details for R3HDM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15032-R3HD1_HUMAN
    Recommended name:
    R3H domain-containing protein 1
    Protein Accession:
    Q15032
    Secondary Accessions:
    • A8K1V0
    • B3KXQ9
    • E9PBB4
    • E9PG42
    • G5E9G8
    • Q8IW32

    Protein attributes for R3HDM1 Gene

    Size:
    1099 amino acids
    Molecular mass:
    120696 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA04878.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for R3HDM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for R3HDM1 Gene

Proteomics data for R3HDM1 Gene at MOPED

Post-translational modifications for R3HDM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for R3HDM1 Gene

Domains for R3HDM1 Gene

Protein Domains for R3HDM1 Gene

Suggested Antigen Peptide Sequences for R3HDM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15032

UniProtKB/Swiss-Prot:

R3HD1_HUMAN :
  • Q15032
Domain:
  • Contains 1 R3H domain.
  • Contains 1 SUZ domain.
genes like me logo Genes that share domains with R3HDM1: view

No data available for Gene Families for R3HDM1 Gene

Function for R3HDM1 Gene

Gene Ontology (GO) - Molecular Function for R3HDM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with R3HDM1: view

Animal Model Products

CRISPR Products

miRNA for R3HDM1 Gene

miRTarBase miRNAs that target R3HDM1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for R3HDM1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for R3HDM1 Gene

Localization for R3HDM1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for R3HDM1 Gene COMPARTMENTS Subcellular localization image for R3HDM1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for R3HDM1 Gene

Pathways for R3HDM1 Gene

SuperPathways for R3HDM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for R3HDM1 Gene

None

No data available for Pathways by source for R3HDM1 Gene

Transcripts for R3HDM1 Gene

Unigene Clusters for R3HDM1 Gene

R3H domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for R3HDM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for R3HDM1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1:
SP2:
SP3: - - - - - - - - -
SP4: - -
SP5:
SP6: - - - - - -
SP7: - -
SP8:
SP9:
SP10:
SP11: - -
SP12: - - -
SP13:
SP14: - - -
SP15: - - - -
SP16:
SP17: - - - - - -

ExUns: 17a · 17b ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2: - -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for R3HDM1 Gene

GeneLoc Exon Structure for
R3HDM1
ECgene alternative splicing isoforms for
R3HDM1

Expression for R3HDM1 Gene

mRNA expression in normal human tissues for R3HDM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for R3HDM1 Gene

This gene is overexpressed in Brain - Cortex (5.4), Brain - Frontal Cortex (BA9) (5.3), and Brain - Anterior cingulate cortex (BA24) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for R3HDM1 Gene

SOURCE GeneReport for Unigene cluster for R3HDM1 Gene Hs.412462

genes like me logo Genes that share expressions with R3HDM1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for R3HDM1 Gene

Orthologs for R3HDM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for R3HDM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia R3HDM1 35
  • 99.64 (n)
  • 99.82 (a)
R3HDM1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia R3HDM1 35
  • 94.34 (n)
  • 94.66 (a)
R3HDM1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia R3HDM1 35
  • 94.12 (n)
  • 95.45 (a)
R3HDM1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia R3hdm1 35
  • 90.04 (n)
  • 90.62 (a)
R3hdm1 16
R3hdm1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia R3HDM1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia R3HDM1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia R3hdm1 35
  • 89.02 (n)
  • 90.15 (a)
chicken
(Gallus gallus)
Aves R3HDM1 35
  • 80.96 (n)
  • 80.15 (a)
R3HDM1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia R3HDM1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia r3hdm1 35
  • 71.95 (n)
  • 70.69 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
r3hdm1 35
  • 62.56 (n)
  • 61.01 (a)
r3hdm1 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta enc 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK121.2 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for R3HDM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for R3HDM1 Gene

ENSEMBL:
Gene Tree for R3HDM1 (if available)
TreeFam:
Gene Tree for R3HDM1 (if available)

Paralogs for R3HDM1 Gene

Paralogs for R3HDM1 Gene

genes like me logo Genes that share paralogs with R3HDM1: view

Variants for R3HDM1 Gene

Sequence variations from dbSNP and Humsavar for R3HDM1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs172690 -- 135,692,101(+) gtagg(C/T)ggggt intron-variant
rs220332 -- 135,687,415(+) cgtgt(A/T)TAAAA intron-variant
rs313517 -- 135,679,937(+) TAGCC(A/G)GGCAT intron-variant
rs313518 -- 135,681,520(+) TAAAG(C/T)GTGAG intron-variant
rs313519 -- 135,681,947(+) CTACA(A/C)AATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for R3HDM1 Gene

Variant ID Type Subtype PubMed ID
esv34026 CNV Loss 18971310
esv2720864 CNV Deletion 23290073

Relevant External Links for R3HDM1 Gene

HapMap Linkage Disequilibrium report
R3HDM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for R3HDM1 Gene

Disorders for R3HDM1 Gene

Relevant External Links for R3HDM1

Genetic Association Database (GAD)
R3HDM1
Human Genome Epidemiology (HuGE) Navigator
R3HDM1
genes like me logo Genes that share disorders with R3HDM1: view

No data available for UniProtKB/Swiss-Prot for R3HDM1 Gene

Publications for R3HDM1 Gene

  1. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4
  2. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for R3HDM1 Gene

Sources for R3HDM1 Gene

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