Free for academic non-profit institutions. Other users need a Commercial license

Aliases for R3HCC1L Gene

Aliases for R3HCC1L Gene

  • R3H Domain And Coiled-Coil Containing 1-Like 2 3
  • Growth Inhibition And Differentiation-Related Protein 88 3 4
  • R3H And Coiled-Coil Domain-Containing Protein 1-Like 3 4
  • Putative Mitochondrial Space Protein 32.1 3 4
  • C10orf28 3 4
  • GIDRP88 3 4
  • Growth Inhibition And Differentiation Related Protein 86 3
  • Coiled-Coil Domain-Containing Protein R3HCC1L 3
  • Chromosome 10 Open Reading Frame 28 2
  • GIDRP86 3
  • PSORT 3

External Ids for R3HCC1L Gene

Previous HGNC Symbols for R3HCC1L Gene

  • C10orf28

Previous GeneCards Identifiers for R3HCC1L Gene

  • GC10P099894

Summaries for R3HCC1L Gene

GeneCards Summary for R3HCC1L Gene

R3HCC1L (R3H Domain And Coiled-Coil Containing 1-Like) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is R3HCC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for R3HCC1L Gene

Genomics for R3HCC1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for R3HCC1L Gene

98,134,624 bp from pter
98,244,897 bp from pter
110,274 bases
Plus strand

Genomic View for R3HCC1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for R3HCC1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for R3HCC1L Gene

No data available for Regulatory Elements for R3HCC1L Gene

Proteins for R3HCC1L Gene

  • Protein details for R3HCC1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein R3HCC1L
    Protein Accession:
    Secondary Accessions:
    • O60598
    • Q5W0B4
    • Q5W0B5
    • Q86VT9
    • Q8N9H0

    Protein attributes for R3HCC1L Gene

    792 amino acids
    Molecular mass:
    87884 Da
    Quaternary structure:
    • May interact with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A
    • Sequence=AAC05748.1; Type=Frameshift; Positions=304; Evidence={ECO:0000305}; Sequence=BAC04364.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for R3HCC1L Gene


neXtProt entry for R3HCC1L Gene

Proteomics data for R3HCC1L Gene at MOPED

Post-translational modifications for R3HCC1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for R3HCC1L Gene

Domains for R3HCC1L Gene

Protein Domains for R3HCC1L Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with R3HCC1L: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for R3HCC1L Gene

Function for R3HCC1L Gene

Gene Ontology (GO) - Molecular Function for R3HCC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with R3HCC1L: view

miRNA for R3HCC1L Gene

miRTarBase miRNAs that target R3HCC1L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for R3HCC1L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for R3HCC1L Gene

Localization for R3HCC1L Gene

Gene Ontology (GO) - Cellular Components for R3HCC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035145 colocalizes_with exon-exon junction complex IDA 20930030
genes like me logo Genes that share ontologies with R3HCC1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for R3HCC1L Gene

Pathways for R3HCC1L Gene

SuperPathways for R3HCC1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for R3HCC1L Gene


No data available for Pathways by source for R3HCC1L Gene

Transcripts for R3HCC1L Gene

Unigene Clusters for R3HCC1L Gene

R3H domain and coiled-coil containing 1-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for R3HCC1L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for R3HCC1L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - -

Relevant External Links for R3HCC1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for R3HCC1L Gene

mRNA expression in normal human tissues for R3HCC1L Gene

Protein differential expression in normal tissues for R3HCC1L Gene

This gene is overexpressed in Testis (28.9), CD8 Tcells (16.5), Blymphocyte (13.4), and Pancreas (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for R3HCC1L Gene

SOURCE GeneReport for Unigene cluster for R3HCC1L Gene Hs.419800

mRNA Expression by UniProt/SwissProt for R3HCC1L Gene

Tissue specificity: Expressed in placenta
genes like me logo Genes that share expressions with R3HCC1L: view

Expression partners for R3HCC1L Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for R3HCC1L Gene

Orthologs for R3HCC1L Gene

This gene was present in the common ancestor of animals.

Orthologs for R3HCC1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia R3HCC1L 35
  • 83.7 (n)
  • 73.1 (a)
R3HCC1L 36
  • 72 (a)
(Canis familiaris)
Mammalia R3HCC1L 35
  • 85.19 (n)
  • 76.87 (a)
R3HCC1L 36
  • 76 (a)
(Mus musculus)
Mammalia R3hcc1l 35
  • 78.65 (n)
  • 66.01 (a)
R3hcc1l 16
R3hcc1l 36
  • 64 (a)
(Pan troglodytes)
Mammalia R3HCC1L 35
  • 99.27 (n)
  • 98.2 (a)
R3HCC1L 36
  • 98 (a)
(Rattus norvegicus)
Mammalia R3hcc1l 35
  • 69.94 (n)
  • 52.84 (a)
(Monodelphis domestica)
Mammalia R3HCC1L 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia R3HCC1L 36
  • 41 (a)
(Gallus gallus)
Aves R3HCC1L 36
  • 55 (a)
(Anolis carolinensis)
Reptilia R3HCC1L 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19631 35
(Danio rerio)
Actinopterygii wufc76b11 35
r3hcc1l 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2162 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for R3HCC1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for R3HCC1L Gene

Gene Tree for R3HCC1L (if available)
Gene Tree for R3HCC1L (if available)

Paralogs for R3HCC1L Gene

Paralogs for R3HCC1L Gene

Selected SIMAP similar genes for R3HCC1L Gene using alignment to 2 proteins: Pseudogenes for R3HCC1L Gene

genes like me logo Genes that share paralogs with R3HCC1L: view

Variants for R3HCC1L Gene

Sequence variations from dbSNP and Humsavar for R3HCC1L Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs869977 -- 98,162,655(+) ACATC(C/T)GTTCG intron-variant
rs884810 -- 98,163,826(+) AATAG(G/T)AAAGT intron-variant
rs884811 -- 98,164,006(+) TTACT(C/G)ACATC intron-variant
rs1023271 -- 98,204,748(-) ataac(A/G)atacg intron-variant
rs1041653 -- 98,201,901(-) tcttt(A/T)aaaaa intron-variant

Relevant External Links for R3HCC1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for R3HCC1L Gene

Disorders for R3HCC1L Gene

No disorders were found for R3HCC1L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for R3HCC1L Gene

Publications for R3HCC1L Gene

  1. The development of a genetic profile of placental gene expression during the first trimester of pregnancy: a potential tool for identifying novel secreted markers. (PMID: 10867487) Page N.M. … Lowry P.J. (Fetal Diagn. Ther. 2000) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. (PMID: 20930030) Kashima I. … Izaurralde E. (Genes Dev. 2010) 3 4

Products for R3HCC1L Gene

Sources for R3HCC1L Gene

Back to Top