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Aliases for R3HCC1L Gene

Aliases for R3HCC1L Gene

  • R3H Domain And Coiled-Coil Containing 1 Like 2 3 5
  • Growth Inhibition And Differentiation-Related Protein 88 3 4
  • R3H And Coiled-Coil Domain-Containing Protein 1-Like 3 4
  • R3H Domain And Coiled-Coil Containing 1-Like 2 3
  • Putative Mitochondrial Space Protein 32.1 3 4
  • C10orf28 3 4
  • GIDRP88 3 4
  • Growth Inhibition And Differentiation Related Protein 86 3
  • Chromosome 10 Open Reading Frame 28 2
  • GIDRP86 3
  • PSORT 3

External Ids for R3HCC1L Gene

Previous HGNC Symbols for R3HCC1L Gene

  • C10orf28

Previous GeneCards Identifiers for R3HCC1L Gene

  • GC10P099894

Summaries for R3HCC1L Gene

GeneCards Summary for R3HCC1L Gene

R3HCC1L (R3H Domain And Coiled-Coil Containing 1 Like) is a Protein Coding gene. Diseases associated with R3HCC1L include Cutaneous Anthrax. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is R3HCC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for R3HCC1L Gene

Genomics for R3HCC1L Gene

Regulatory Elements for R3HCC1L Gene

Enhancers for R3HCC1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around R3HCC1L on UCSC Golden Path with GeneCards custom track

Promoters for R3HCC1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around R3HCC1L on UCSC Golden Path with GeneCards custom track

Genomic Location for R3HCC1L Gene

98,134,624 bp from pter
98,244,897 bp from pter
110,274 bases
Plus strand

Genomic View for R3HCC1L Gene

Genes around R3HCC1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
R3HCC1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for R3HCC1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for R3HCC1L Gene

Proteins for R3HCC1L Gene

  • Protein details for R3HCC1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein R3HCC1L
    Protein Accession:
    Secondary Accessions:
    • O60598
    • Q5W0B4
    • Q5W0B5
    • Q86VT9
    • Q8N9H0

    Protein attributes for R3HCC1L Gene

    792 amino acids
    Molecular mass:
    87884 Da
    Quaternary structure:
    • May interact with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A.
    • Sequence=AAC05748.1; Type=Frameshift; Positions=304; Evidence={ECO:0000305}; Sequence=BAC04364.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for R3HCC1L Gene


neXtProt entry for R3HCC1L Gene

Proteomics data for R3HCC1L Gene at MOPED

Post-translational modifications for R3HCC1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for R3HCC1L Gene

Domains & Families for R3HCC1L Gene

Protein Domains for R3HCC1L Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with R3HCC1L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for R3HCC1L Gene

Function for R3HCC1L Gene

Gene Ontology (GO) - Molecular Function for R3HCC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with R3HCC1L: view

Phenotypes for R3HCC1L Gene

GenomeRNAi human phenotypes for R3HCC1L:
genes like me logo Genes that share phenotypes with R3HCC1L: view

Animal Model Products

miRNA for R3HCC1L Gene

miRTarBase miRNAs that target R3HCC1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for R3HCC1L Gene

Localization for R3HCC1L Gene

Subcellular locations from

Jensen Localization Image for R3HCC1L Gene COMPARTMENTS Subcellular localization image for R3HCC1L gene
Compartment Confidence
nucleus 4
mitochondrion 2
chloroplast 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for R3HCC1L Gene

Pathways & Interactions for R3HCC1L Gene

SuperPathways for R3HCC1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for R3HCC1L Gene


No data available for Pathways by source and SIGNOR curated interactions for R3HCC1L Gene

Drugs & Compounds for R3HCC1L Gene

No Compound Related Data Available

Transcripts for R3HCC1L Gene

Unigene Clusters for R3HCC1L Gene

R3H domain and coiled-coil containing 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for R3HCC1L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - -

Relevant External Links for R3HCC1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for R3HCC1L Gene

mRNA expression in normal human tissues for R3HCC1L Gene

Protein differential expression in normal tissues from HIPED for R3HCC1L Gene

This gene is overexpressed in Testis (28.9), CD8 Tcells (16.5), Blymphocyte (13.4), and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for R3HCC1L Gene

SOURCE GeneReport for Unigene cluster for R3HCC1L Gene Hs.419800

mRNA Expression by UniProt/SwissProt for R3HCC1L Gene

Tissue specificity: Expressed in placenta.
genes like me logo Genes that share expression patterns with R3HCC1L: view

Protein tissue co-expression partners for R3HCC1L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for R3HCC1L Gene

Orthologs for R3HCC1L Gene

This gene was present in the common ancestor of animals.

Orthologs for R3HCC1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia R3HCC1L 35
  • 83.7 (n)
  • 73.1 (a)
R3HCC1L 36
  • 72 (a)
(Canis familiaris)
Mammalia R3HCC1L 35
  • 85.19 (n)
  • 76.87 (a)
R3HCC1L 36
  • 76 (a)
(Mus musculus)
Mammalia R3hcc1l 35
  • 78.65 (n)
  • 66.01 (a)
R3hcc1l 16
R3hcc1l 36
  • 64 (a)
(Pan troglodytes)
Mammalia R3HCC1L 35
  • 99.27 (n)
  • 98.2 (a)
R3HCC1L 36
  • 98 (a)
(Rattus norvegicus)
Mammalia R3hcc1l 35
  • 69.94 (n)
  • 52.84 (a)
(Monodelphis domestica)
Mammalia R3HCC1L 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia R3HCC1L 36
  • 41 (a)
(Gallus gallus)
Aves R3HCC1L 36
  • 55 (a)
(Anolis carolinensis)
Reptilia R3HCC1L 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19631 35
(Danio rerio)
Actinopterygii wufc76b11 35
r3hcc1l 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2162 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for R3HCC1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for R3HCC1L Gene

Gene Tree for R3HCC1L (if available)
Gene Tree for R3HCC1L (if available)

Paralogs for R3HCC1L Gene

Paralogs for R3HCC1L Gene

(2) SIMAP similar genes for R3HCC1L Gene using alignment to 2 proteins: Pseudogenes for R3HCC1L Gene

genes like me logo Genes that share paralogs with R3HCC1L: view

Variants for R3HCC1L Gene

Sequence variations from dbSNP and Humsavar for R3HCC1L Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11189513 - 98,209,811(+) TTCTC(A/G)CACAG intron-variant, reference, missense
rs1952061 - 98,231,651(-) CAGTA(A/C/T)GAAAT reference, missense
rs12775148 - 98,208,451(+) CTGAA(C/T)CCAAA intron-variant, reference, missense
rs7922159 - 98,208,828(+) ATAAA(A/C)CTAAG intron-variant, reference, missense
rs35373035 - 98,208,895(-) TCCGC(C/T)GCTGG intron-variant, reference, missense

Variation tolerance for R3HCC1L Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.26; 76.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for R3HCC1L Gene

Disorders for R3HCC1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for R3HCC1L Gene - From: DISEASES

Disorder Aliases PubMed IDs
cutaneous anthrax
  • anthrax, skin type
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for R3HCC1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with R3HCC1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for R3HCC1L Gene

Publications for R3HCC1L Gene

  1. SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. (PMID: 20930030) Kashima I. … Izaurralde E. (Genes Dev. 2010) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for R3HCC1L Gene

Sources for R3HCC1L Gene