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Aliases for QTRTD1 Gene

Aliases for QTRTD1 Gene

  • Queuine TRNA-Ribosyltransferase Domain Containing 1 2 3
  • Queuine TRNA-Ribosyltransferase Domain-Containing Protein 1 4
  • EC 2.4.2.29 4

External Ids for QTRTD1 Gene

Previous GeneCards Identifiers for QTRTD1 Gene

  • GC03P115096
  • GC03P115258
  • GC03P113724
  • GC03P111150

Summaries for QTRTD1 Gene

Entrez Gene Summary for QTRTD1 Gene

  • This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for QTRTD1 Gene

QTRTD1 (Queuine TRNA-Ribosyltransferase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include queuine tRNA-ribosyltransferase activity. An important paralog of this gene is QTRT1.

UniProtKB/Swiss-Prot for QTRTD1 Gene

  • Interacts with QTRT1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QTRTD1 Gene

Genomics for QTRTD1 Gene

Regulatory Elements for QTRTD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for QTRTD1 Gene

Start:
114,005,833 bp from pter
End:
114,088,422 bp from pter
Size:
82,590 bases
Orientation:
Plus strand

Genomic View for QTRTD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for QTRTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QTRTD1 Gene

Proteins for QTRTD1 Gene

  • Protein details for QTRTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H974-QTRD1_HUMAN
    Recommended name:
    Queuine tRNA-ribosyltransferase subunit QTRTD1
    Protein Accession:
    Q9H974
    Secondary Accessions:
    • A6NGE9
    • B7Z472
    • B7Z5R2
    • J3KR78
    • Q6IA59

    Protein attributes for QTRTD1 Gene

    Size:
    415 amino acids
    Molecular mass:
    46713 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with QTRT1.

    Alternative splice isoforms for QTRTD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QTRTD1 Gene

Proteomics data for QTRTD1 Gene at MOPED

Post-translational modifications for QTRTD1 Gene

  • Ubiquitination at Lys211
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for QTRTD1 Gene

Domains for QTRTD1 Gene

Protein Domains for QTRTD1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H974

UniProtKB/Swiss-Prot:

QTRD1_HUMAN :
  • Q9H974
Family:
  • Belongs to the queuine tRNA-ribosyltransferase family. QTRTD1 subfamily.
genes like me logo Genes that share domains with QTRTD1: view

No data available for Gene Families for QTRTD1 Gene

Function for QTRTD1 Gene

Molecular function for QTRTD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Guanine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine.
UniProtKB/Swiss-Prot Function: Interacts with QTRT1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

Enzyme Numbers (IUBMB) for QTRTD1 Gene

Gene Ontology (GO) - Molecular Function for QTRTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0008479 contributes_to queuine tRNA-ribosyltransferase activity ISS --
genes like me logo Genes that share ontologies with QTRTD1: view

Phenotypes for QTRTD1 Gene

genes like me logo Genes that share phenotypes with QTRTD1: view

Animal Model Products

CRISPR Products

miRNA for QTRTD1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for QTRTD1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for QTRTD1 Gene

Localization for QTRTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QTRTD1 Gene

Cytoplasm. Mitochondrion. Note=May associate with the mitochondrion outer membrane. {ECO:0000255 HAMAP-Rule:MF_03043}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QTRTD1 Gene COMPARTMENTS Subcellular localization image for QTRTD1 gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for QTRTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion ISS --
genes like me logo Genes that share ontologies with QTRTD1: view

Pathways for QTRTD1 Gene

SuperPathways for QTRTD1 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H974-QTRD1_HUMAN

  • Pathway: tRNA modification; tRNA-queuosine biosynthesis.

Interacting Proteins for QTRTD1 Gene

Gene Ontology (GO) - Biological Process for QTRTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification --
GO:0008616 queuosine biosynthetic process ISS --
genes like me logo Genes that share ontologies with QTRTD1: view

No data available for Pathways by source for QTRTD1 Gene

Compounds for QTRTD1 Gene

(1) HMDB Compounds for QTRTD1 Gene

Compound Synonyms Cas Number PubMed IDs
Queuine
  • 2-amino-5-((((1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-1,7-dihydro-4H-pyrrolo(2,3-d)pyrimidin-4-one
72496-59-4
genes like me logo Genes that share compounds with QTRTD1: view

Transcripts for QTRTD1 Gene

Unigene Clusters for QTRTD1 Gene

Queuine tRNA-ribosyltransferase domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for QTRTD1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for QTRTD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for QTRTD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - -
SP2: - -
SP3: - - - - - - - -
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for QTRTD1 Gene

GeneLoc Exon Structure for
QTRTD1
ECgene alternative splicing isoforms for
QTRTD1

Expression for QTRTD1 Gene

mRNA expression in normal human tissues for QTRTD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for QTRTD1 Gene

SOURCE GeneReport for Unigene cluster for QTRTD1 Gene Hs.477162

genes like me logo Genes that share expressions with QTRTD1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for QTRTD1 Gene

Orthologs for QTRTD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QTRTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QTRTD1 35
  • 99.77 (n)
  • 99.53 (a)
QTRTD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia QTRTD1 35
  • 90.17 (n)
  • 91.45 (a)
QTRTD1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QTRTD1 35
  • 90.28 (n)
  • 91.81 (a)
QTRTD1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qtrtd1 35
  • 83.9 (n)
  • 85.39 (a)
Qtrtd1 16
Qtrtd1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia QTRTD1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QTRTD1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Qtrtd1 35
  • 86.1 (n)
  • 87.95 (a)
chicken
(Gallus gallus)
Aves QTRTD1 35
  • 68.28 (n)
  • 64.32 (a)
QTRTD1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QTRTD1 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15850 35
tropical clawed frog
(Silurana tropicalis)
Amphibia qtrtd1 35
  • 64.16 (n)
  • 63.11 (a)
Str.7249 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5124 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15434 35
qtrtd1 35
  • 60.92 (n)
  • 57.14 (a)
qtrtd1 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta QTRD1_ANOGA 35
  • 46.37 (n)
  • 33.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3434 35
  • 44.92 (n)
  • 33.16 (a)
CG3434 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tgt-2 35
  • 43.17 (n)
  • 31.81 (a)
tgt-2 36
  • 27 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os10g0141900 35
  • 45.47 (n)
  • 34.51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04654 35
  • 40.65 (n)
  • 30.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2F3.13c 35
  • 43.09 (n)
  • 30.14 (a)
Species with no ortholog for QTRTD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QTRTD1 Gene

ENSEMBL:
Gene Tree for QTRTD1 (if available)
TreeFam:
Gene Tree for QTRTD1 (if available)

Paralogs for QTRTD1 Gene

Paralogs for QTRTD1 Gene

genes like me logo Genes that share paralogs with QTRTD1: view

Variants for QTRTD1 Gene

Sequence variations from dbSNP and Humsavar for QTRTD1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1129632 -- 114,087,745(+) tcatg(A/G)cagaa utr-variant-3-prime, downstream-variant-500B
rs1486013 -- 114,078,604(-) GCATT(C/T)TGAGA intron-variant
rs1542659 -- 114,067,396(+) ATTTA(A/G)GCACA intron-variant
rs1872575 -- 114,086,132(-) GAAGT(C/T)TTAAA utr-variant-3-prime
rs2018088 -- 114,072,352(+) TTCAC(C/G)ATGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QTRTD1 Gene

Variant ID Type Subtype PubMed ID
nsv877352 CNV Gain 21882294
nsv877353 CNV Gain 21882294

Relevant External Links for QTRTD1 Gene

HapMap Linkage Disequilibrium report
QTRTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QTRTD1 Gene

Disorders for QTRTD1 Gene

Relevant External Links for QTRTD1

Human Genome Epidemiology (HuGE) Navigator
QTRTD1
genes like me logo Genes that share disorders with QTRTD1: view

No data available for UniProtKB/Swiss-Prot for QTRTD1 Gene

Publications for QTRTD1 Gene

  1. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. (PMID: 20354154) Chen Y.C. … Garcia G.A. (RNA 2010) 3 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. An investigation into the human serum "interactome". (PMID: 15174051) Zhou M. … Conrads T.P. (Electrophoresis 2004) 3
  5. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. (PMID: 16009940) Zhao C. … Krug R.M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3

Products for QTRTD1 Gene

Sources for QTRTD1 Gene

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