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QTRTD1 Gene

protein-coding GIFtS: 47

GC03P115258

queuine tRNA-ribosyltransferase domain containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ12960 ^¹, ²

Descriptions
queuine tRNA-ribosyltransferase domain containing 1 ^²

External Ids
HGNC: 25771¹
Entrez Gene: 79691²
UniProtKB: Q9H974³
Ensembl: ENSG00000151576⁷

Search outside databases for aliases for QTRTD1 gene

Previous GC identifer: GC03P115096

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the QTRTD1 gene

Entrez Gene cytogenetic band: 3q13.31 Ensembl cytogenetic band: 3q13.31 HGNC cytogenetic band: 3q13.31

QTRTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P115258: (about GC identifiers)

Start:	115,258,301 bp from pter
End:	115,289,959 bp from pter
Size:	31,659 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: QTRD1_HUMAN, Q9H974 (See protein sequence)

Recommended Name: Queuine tRNA-ribosyltransferase domain-containing protein 1

Size: 415 amino acids; 46713 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Secondary accessions: A6NGE9 Q6IA59

REFSEQ proteins: NP_078914.1

ENSEMBL proteins:

ENSP00000281273

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (QTRTD1)
	Human Recombinant Proteins from Abnova (QTRTD1)

OriGene Purified Recombinant Human Protein: QTRTD1

Antibodies for QTRTD1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (QTRTD1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (QTRTD1)
	Novus Biologicals Antibody for QTRTD1

Assays for QTRTD1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9H974

ProtoNet protein and cluster: Q9H974

UniProtKB/Swiss-Prot: QTRD1_HUMAN, Q9H974

Similarity: Belongs to the queuine tRNA-ribosyltransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QTRTD1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024638

Applied Biosystems Silencer® siRNAs for QTRTD1

Sigma-Aldrich siRNA for QTRTD1

Sigma-Aldrich shRNA for QTRTD1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for QTRTD1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024638
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024638
untagged cDNA clone in CMV expression vector: NM_024638

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024638

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--
GO:0008479	queuine tRNA-ribosyltransferase activity	IEA	--
GO:0016757	transferase activity, transferring glycosyl groups	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008616	queuosine biosynthetic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for QTRTD1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QTRTD1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024638

Sigma-Aldrich siRNA for QTRTD1

Sigma-Aldrich shRNA for QTRTD1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024638

REFSEQ mRNAs for QTRTD1 gene:

NM_024638.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024638

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024638
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024638
                                 untagged cDNA clone in CMV expression vector: NM_024638

Additional cDNA sequence:

AK023022.1 AK296938.1 AK299313.1 AL832215.1 AL833709.1 BC034559.2 BC039265.1 CR457296.1

CR595228.1 CR614436.1

10 DOTS entries:

DT.100749889 DT.309371 DT.106131 DT.92003078 DT.100689019 DT.120867109 DT.75113057 DT.97809317

DT.40111843 DT.91868796

24/91 AceView cDNA sequences (see all 91 ):

AL515410 CB044300 AA406030 AI292226 NM_024638 AI702965 BM457023 CA431921

BX091224 BC039265 AU132268 AK023022 BU156561 AI890753 CR614436 BQ426147

BQ423492 CR595228 BE048722 AU131204 AW293598 AL833709 BG107112 BE613628

highest scoring ESTs for QTRTD1:

AA975060 AA406029 AA406030 AA825888 AF147773 AI261689 AI288960 AI292226 AI695627 AI699867

Unigene Cluster for QTRTD1:

Queuine tRNA-ribosyltransferase domain containing 1

Hs.477162 [show with all ESTs]

Unigene Representative Sequence: NM_024638

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for QTRTD1 (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8	^	9	^	10a	·	10b	^	11	^	12
SP1:									-																								-
SP2:									-				-
SP3:							-		-		-		-		-		-												-				-
SP4:
SP5:																	-

About this scheme

ECgene alternative splicing isoforms for QTRTD1

1 Ensembl transcript including schematic representation:

ENST00000281273

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

QTRTD1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for QTRTD1

¹ / ² / ³

4 probe-sets matching QTRTD1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
80751_at²^{, 3}	U95-E	1	1.00	1.00	0.67	0.86	AI702965	0.60	1.00	0.82	1
45613_at²^{, 3}	U95-B	1	0.81	1.00	0.43	1.16	AA975060	1.00	1.00	1.00	1
219178_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024638	0.60	1.00	0.82	1
219178_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTTTATTTA

SOURCE GeneReport for Unigene cluster: Hs.477162

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for QTRTD1 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	QTRTD1¹	--	queuine tRNA-ribosyltransferase domain containing 1	90.28(n) 91.81(a)	487983 XM_545105.2 XP_545105.2
chimpanzee (Pan troglodytes)	QTRTD1¹	--	queuine tRNA-ribosyltransferase domain containing 1	99.76(n) 99.52(a)	460595 XM_516660.2 XP_516660.2
cow (Bos taurus)	QTRTD1¹	--	queuine tRNA-ribosyltransferase domain containing 1	89.96(n) 91.81(a)	508374 XM_585142.2 XP_585142.2
rat (Rattus norvegicus)	Qtrtd1¹	--	queuine tRNA-ribosyltransferase domain containing 1	86.1(n) 87.95(a)	288364 XM_221768.2 XP_221768.2
mouse (Mus musculus)	Qtrtd1^{1, 5}	16⁵	queuine tRNA-ribosyltransferase domain containing 1^{1, 5}	83.9(n)¹ 85.39(a)¹	106248¹ NM_029128.2¹ NP_083404.2¹ AI648807⁵ AK014045⁵ (see all 12)

About this table Species with no ortholog for QTRTD1

ENSEMBL Gene Tree for QTRTD1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for QTRTD1 gene

QTRT1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/154 NCBI SNPs in QTRTD1 are shown (see all 154 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 67)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1872575^1,2	A,C,F,H,O	115287669(-)	`GAAGTT/CTTAAA`	1	--	ut3¹ ese³		17	EA NA MN EU WA	2752
	rs3732788^1,2	A,C,F,H	115287549(+)	`TTGGAT/CATAAG`	1	--	ut3¹		8	EA EU WA NA	2052
--	rs1129632^1,2	C,F	115289282(+)	`tcatgG/Acagaa`	1	--	ut3¹		1	MN	184
	rs1542659^1,2	A,C,F,H,O	115268933(+)	`ATTTAA/GGCACA`	1	--	int¹		18	EA NA NS EU WA	1050
--	rs9851015^1,2	A,C,F,H	115275035(+)	`tgtcaA/Gcttcc`	1	--	int¹		4	EU EA WA	420
	rs6782373^1,2	A,C,F,H	115276844(+)	`tcataC/Tgtgta`	1	--	int¹		8	EU EA WA	838
	rs9682132^1,2	A,C,F,H	115265080(+)	`ATTTAT/AGTGGG`	1	--	int¹		4	EU EA WA	418
	rs9825349^1,2	A,C,F,H	115264631(+)	`GGTCCG/ATTTAA`	1	--	int¹		4	EU EA WA	418
	rs9881685^1,2	A,C,F,H	115286198(+)	`taactG/Atacta`	1	--	int¹		4	EU EA WA	418
	rs7631864^1,2	A,C,F,H	115278524(+)	`GCAGGG/AAAGGA`	1	--	int¹ trp³		8	EA NA EU WA	636

About this table

HapMap Linkage Disequilibrium images for QTRTD1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for QTRTD1 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)⁴ Muzny D.M....Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene. (PubMed id 14602484)¹ Vandenbergh D.J....Severns V. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79691	HGNC: 25771	AceView: QTRTD1	Ensembl:ENSG00000151576	euGenes: HUgn79691
ECgene: QTRTD1	H-InvDB: QTRTD1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for QTRTD1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for QTRTD1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for QTRTD1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for QTRTD1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for QTRTD1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (QTRTD1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for QTRTD1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for QTRTD1

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QTRTD1 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for QTRTD1

Summaries
for QTRTD1

Genomic Location
for QTRTD1

Proteins
for QTRTD1

Protein Domains/
Families
for QTRTD1

Gene Function
for QTRTD1

Pathways & Interactions
for QTRTD1

Drugs & Compounds
for QTRTD1

Transcripts
for QTRTD1

Expression
for QTRTD1

Orthologs
for QTRTD1

Paralogs
for QTRTD1

SNPs/Variants
for QTRTD1

Disorders & Mutations
for QTRTD1

Medical News
for QTRTD1

Publications
for QTRTD1

Search for QTRTD1

Genome Databases showing QTRTD1

Other Databases showing QTRTD1

Specialized Databases showing QTRTD1

Licensable Technologies
for QTRTD1

Services
for QTRTD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

QTRTD1 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor QTRTD1

Summariesfor QTRTD1

Genomic Locationfor QTRTD1

Proteinsfor QTRTD1

Protein Domains/Familiesfor QTRTD1

Gene Functionfor QTRTD1

Pathways & Interactionsfor QTRTD1

Drugs & Compoundsfor QTRTD1

Transcriptsfor QTRTD1

Expression for QTRTD1

Orthologsfor QTRTD1

Paralogsfor QTRTD1

SNPs/Variantsfor QTRTD1

Disorders & Mutationsfor QTRTD1

Medical Newsfor QTRTD1

Publicationsfor QTRTD1

Search for QTRTD1

Genome Databases showing QTRTD1

Other Databases showing QTRTD1

Specialized Databases showing QTRTD1

Licensable Technologiesfor QTRTD1

Servicesfor QTRTD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for QTRTD1

Summaries
for QTRTD1

Genomic Location
for QTRTD1

Proteins
for QTRTD1

Protein Domains/
Families
for QTRTD1

Gene Function
for QTRTD1

Pathways & Interactions
for QTRTD1

Drugs & Compounds
for QTRTD1

Transcripts
for QTRTD1

Expression
for QTRTD1

Orthologs
for QTRTD1

Paralogs
for QTRTD1

SNPs/Variants
for QTRTD1

Disorders & Mutations
for QTRTD1

Medical News
for QTRTD1

Publications
for QTRTD1

Licensable Technologies
for QTRTD1

Services
for QTRTD1