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Aliases for QTRT2 Gene

Aliases for QTRT2 Gene

  • Queuine TRNA-Ribosyltransferase Accessory Subunit 2 2 3
  • Queuine TRNA-Ribosyltransferase Domain Containing 1 2 3 5
  • QTRTD1 3 4 5
  • Queuine TRNA-Ribosyltransferase Domain-Containing Protein 1 4
  • EC 2.4.2.29 4

External Ids for QTRT2 Gene

Previous HGNC Symbols for QTRT2 Gene

  • QTRTD1

Summaries for QTRT2 Gene

Entrez Gene Summary for QTRT2 Gene

  • This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for QTRT2 Gene

QTRT2 (Queuine TRNA-Ribosyltransferase Accessory Subunit 2) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. An important paralog of this gene is QTRT1.

UniProtKB/Swiss-Prot for QTRT2 Gene

  • Interacts with QTRT1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QTRT2 Gene

Genomics for QTRT2 Gene

Regulatory Elements for QTRT2 Gene

Enhancers for QTRT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around QTRT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for QTRT2 Gene

Chromosome:
3
Start:
114,005,833 bp from pter
End:
114,088,422 bp from pter
Size:
82,590 bases
Orientation:
Plus strand

Genomic View for QTRT2 Gene

Genes around QTRT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QTRT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QTRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QTRT2 Gene

Proteins for QTRT2 Gene

  • Protein details for QTRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H974-QTRD1_HUMAN
    Recommended name:
    Queuine tRNA-ribosyltransferase subunit QTRTD1
    Protein Accession:
    Q9H974
    Secondary Accessions:
    • A6NGE9
    • B7Z472
    • B7Z5R2
    • J3KR78
    • Q6IA59

    Protein attributes for QTRT2 Gene

    Size:
    415 amino acids
    Molecular mass:
    46713 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with QTRT1.

    Alternative splice isoforms for QTRT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QTRT2 Gene

Proteomics data for QTRT2 Gene at MOPED

Post-translational modifications for QTRT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for QTRT2 Gene

Domains & Families for QTRT2 Gene

Protein Domains for QTRT2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H974

UniProtKB/Swiss-Prot:

QTRD1_HUMAN :
  • Belongs to the queuine tRNA-ribosyltransferase family. QTRTD1 subfamily.
Family:
  • Belongs to the queuine tRNA-ribosyltransferase family. QTRTD1 subfamily.
genes like me logo Genes that share domains with QTRT2: view

No data available for Gene Families for QTRT2 Gene

Function for QTRT2 Gene

Molecular function for QTRT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Guanine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine.
UniProtKB/Swiss-Prot Function:
Interacts with QTRT1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

Enzyme Numbers (IUBMB) for QTRT2 Gene

genes like me logo Genes that share phenotypes with QTRT2: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QTRT2 Gene

Localization for QTRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QTRT2 Gene

Cytoplasm. Mitochondrion. Note=May associate with the mitochondrion outer membrane. {ECO:0000255 HAMAP-Rule:MF_03043}.

Gene Ontology (GO) - Cellular Components for QTRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with QTRT2: view

No data available for Subcellular locations from COMPARTMENTS for QTRT2 Gene

Pathways & Interactions for QTRT2 Gene

genes like me logo Genes that share pathways with QTRT2: view

Pathways by source for QTRT2 Gene

UniProtKB/Swiss-Prot Q9H974-QTRD1_HUMAN

  • Pathway: tRNA modification; tRNA-queuosine biosynthesis.

Interacting Proteins for QTRT2 Gene

Gene Ontology (GO) - Biological Process for QTRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008616 queuosine biosynthetic process IEA,ISS --
genes like me logo Genes that share ontologies with QTRT2: view

No data available for SIGNOR curated interactions for QTRT2 Gene

Drugs & Compounds for QTRT2 Gene

(1) Drugs for QTRT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanine Experimental Pharma 0

(2) Additional Compounds for QTRT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7-Aminomethyl-7-carbaguanine
  • 7-Aminomethyl-7-deazaguanine
  • PreQ1
queuine
  • 2-Amino-5-((((1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-1,7-dihydro-4H-pyrrolo(2,3-D)pyrimidin-4-one
  • 7-(3,4-trans-4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanine
  • Base Q
  • Queuine
72496-59-4
genes like me logo Genes that share compounds with QTRT2: view

Transcripts for QTRT2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for QTRT2 Gene

No ASD Table

Relevant External Links for QTRT2 Gene

GeneLoc Exon Structure for
QTRT2
ECgene alternative splicing isoforms for
QTRT2

Expression for QTRT2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for QTRT2 Gene

Orthologs for QTRT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QTRT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia QTRTD1 35
  • 90.17 (n)
  • 91.45 (a)
QTRTD1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QTRTD1 35
  • 90.28 (n)
  • 91.81 (a)
QTRTD1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qtrtd1 35
  • 83.9 (n)
  • 85.39 (a)
Qtrtd1 16
Qtrtd1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia QTRTD1 35
  • 99.77 (n)
  • 99.53 (a)
QTRTD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Qtrtd1 35
  • 86.1 (n)
  • 87.95 (a)
oppossum
(Monodelphis domestica)
Mammalia QTRTD1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QTRTD1 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves QTRTD1 35
  • 68.28 (n)
  • 64.32 (a)
QTRTD1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QTRTD1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qtrtd1 35
  • 64.16 (n)
  • 63.11 (a)
Str.7249 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15850 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15434 35
qtrtd1 35
  • 60.92 (n)
  • 57.14 (a)
qtrtd1 36
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5124 35
African malaria mosquito
(Anopheles gambiae)
Insecta QTRD1_ANOGA 35
  • 46.37 (n)
  • 33.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3434 35
  • 44.92 (n)
  • 33.16 (a)
CG3434 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tgt-2 35
  • 43.17 (n)
  • 31.81 (a)
tgt-2 36
  • 27 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os10g0141900 35
  • 45.47 (n)
  • 34.51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04654 35
  • 40.65 (n)
  • 30.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2F3.13c 35
  • 43.09 (n)
  • 30.14 (a)
Species with no ortholog for QTRT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QTRT2 Gene

ENSEMBL:
Gene Tree for QTRT2 (if available)
TreeFam:
Gene Tree for QTRT2 (if available)

Paralogs for QTRT2 Gene

Paralogs for QTRT2 Gene

genes like me logo Genes that share paralogs with QTRT2: view

Variants for QTRT2 Gene

Sequence variations from dbSNP and Humsavar for QTRT2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1872575 -- 114,086,132(-) GAAGT(C/T)TTAAA utr-variant-3-prime
rs1129632 -- 114,087,745(+) tcatg(A/G)cagaa utr-variant-3-prime
rs2306730 -- 114,062,889(+) TCATG(G/T)GTGTA intron-variant
rs2306731 -- 114,063,181(+) CAGGT(A/G)TTGAT intron-variant
rs7611761 -- 114,059,787(+) TCTTC(A/G)TTAAT intron-variant

Variation tolerance for QTRT2 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for QTRT2 Gene

Disorders for QTRT2 Gene

Relevant External Links for QTRT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QTRT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QTRT2

No disorders were found for QTRT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QTRT2 Gene

Publications for QTRT2 Gene

  1. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. (PMID: 20354154) Chen Y.C. … Garcia G.A. (RNA 2010) 2 3 23 67
  2. Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. (PMID: 19414587) Boland C. … Kelly V.P. (J. Biol. Chem. 2009) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases. (PMID: 21131277) Chen Y.C. … Garcia G.A. (Nucleic Acids Res. 2011) 3

Products for QTRT2 Gene

Sources for QTRT2 Gene

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