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Aliases for QTRT2 Gene

Aliases for QTRT2 Gene

  • Queuine TRNA-Ribosyltransferase Accessory Subunit 2 2 3 5
  • Queuine TRNA-Ribosyltransferase Domain Containing 1 2 3
  • QTRTD1 3 4
  • Queuine TRNA-Ribosyltransferase Domain-Containing Protein 1 4
  • Queuine TRNA-Ribosyltransferase Subunit QTRTD1 3

External Ids for QTRT2 Gene

Previous HGNC Symbols for QTRT2 Gene

  • QTRTD1

Summaries for QTRT2 Gene

Entrez Gene Summary for QTRT2 Gene

  • This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for QTRT2 Gene

QTRT2 (Queuine TRNA-Ribosyltransferase Accessory Subunit 2) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. An important paralog of this gene is QTRT1.

UniProtKB/Swiss-Prot for QTRT2 Gene

  • Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

Additional gene information for QTRT2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QTRT2 Gene

Genomics for QTRT2 Gene

GeneHancer (GH) Regulatory Elements for QTRT2 Gene

Promoters and enhancers for QTRT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I114055 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 565.8 +50.9 50873 2.8 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 E2F8 ZNF207 QTRT2 CCDC191 SPICE1 LOC391566 GC03M113853
GH03I114066 Promoter 0.5 EPDnew 550.2 +61.0 60971 0.1 QTRT2 CCDC191 LOC391566 GC03M113853
GH03I113742 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24 -259.5 -259537 8.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ATP6V1A ENSG00000242659 NAA50 SPICE1 QTRT2 NEPRO LOC101180897 CFAP44 BOC USF3
GH03I113838 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 23.8 -166.9 -166862 1.5 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF48 ZNF207 ZNF143 RUNX3 RXRA GRAMD1C QTRT2 CCDC191 SPICE1 GC03M113852
GH03I113694 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.1 -308.7 -308660 4.8 HDGF PKNOX1 ARID4B NEUROD1 SIN3A DMAP1 YBX1 ZBTB7B YY1 E2F8 USF3 NAA50 GTPBP8 NEPRO QTRT2 SIDT1 ATP6V1A GC03P113719
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around QTRT2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for QTRT2 Gene

Genomic Locations for QTRT2 Gene
chr3:114,005,833-114,088,422
(GRCh38/hg38)
Size:
82,590 bases
Orientation:
Plus strand
chr3:113,724,680-113,807,269
(GRCh37/hg19)

Genomic View for QTRT2 Gene

Genes around QTRT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QTRT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QTRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QTRT2 Gene

Proteins for QTRT2 Gene

  • Protein details for QTRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H974-QTRT2_HUMAN
    Recommended name:
    Queuine tRNA-ribosyltransferase accessory subunit 2
    Protein Accession:
    Q9H974
    Secondary Accessions:
    • A6NGE9
    • B7Z472
    • B7Z5R2
    • J3KR78
    • Q6IA59

    Protein attributes for QTRT2 Gene

    Size:
    415 amino acids
    Molecular mass:
    46713 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.

    Alternative splice isoforms for QTRT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QTRT2 Gene

Post-translational modifications for QTRT2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for QTRT2 Gene

Domains & Families for QTRT2 Gene

Gene Families for QTRT2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for QTRT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H974

UniProtKB/Swiss-Prot:

QTRT2_HUMAN :
  • Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
Family:
  • Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
genes like me logo Genes that share domains with QTRT2: view

Function for QTRT2 Gene

Molecular function for QTRT2 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

Phenotypes From GWAS Catalog for QTRT2 Gene

Gene Ontology (GO) - Molecular Function for QTRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008479 contributes_to queuine tRNA-ribosyltransferase activity IC 20354154
GO:0016763 transferase activity, transferring pentosyl groups IEA --
GO:0042803 protein homodimerization activity IDA 20354154
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IDA 20354154
genes like me logo Genes that share ontologies with QTRT2: view
genes like me logo Genes that share phenotypes with QTRT2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QTRT2 Gene

Localization for QTRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QTRT2 Gene

Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=May associate with the mitochondrion outer membrane. {ECO:0000255 HAMAP-Rule:MF_03043}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QTRT2 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for QTRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion ISS --
GO:0005741 mitochondrial outer membrane TAS --
GO:0016020 membrane IEA --
GO:0043234 protein complex IPI 20354154
genes like me logo Genes that share ontologies with QTRT2: view

Pathways & Interactions for QTRT2 Gene

genes like me logo Genes that share pathways with QTRT2: view

Pathways by source for QTRT2 Gene

Interacting Proteins for QTRT2 Gene

Gene Ontology (GO) - Biological Process for QTRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS,IEA --
GO:0008033 tRNA processing IEA --
GO:0101030 tRNA-guanine transglycosylation IDA 20354154
genes like me logo Genes that share ontologies with QTRT2: view

No data available for SIGNOR curated interactions for QTRT2 Gene

Drugs & Compounds for QTRT2 Gene

(1) Drugs for QTRT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanine Experimental Pharma 0

(2) Additional Compounds for QTRT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7-Aminomethyl-7-carbaguanine
  • 7-Aminomethyl-7-deazaguanine
  • PreQ1
queuine
  • 2-Amino-5-((((1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-1,7-dihydro-4H-pyrrolo(2,3-D)pyrimidin-4-one
  • 7-(3,4-trans-4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanine
  • Base Q
  • Queuine
72496-59-4
genes like me logo Genes that share compounds with QTRT2: view

Transcripts for QTRT2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for QTRT2 Gene

No ASD Table

Relevant External Links for QTRT2 Gene

GeneLoc Exon Structure for
QTRT2
ECgene alternative splicing isoforms for
QTRT2

Expression for QTRT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of QTRT2 Gene:

QTRT2

Evidence on tissue expression from TISSUES for QTRT2 Gene

  • Lymph node(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QTRT2 Gene

Orthologs for QTRT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QTRT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QTRTD1 33 34
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia QTRTD1 33 34
  • 90.28 (n)
cow
(Bos Taurus)
Mammalia QTRTD1 33 34
  • 90.17 (n)
rat
(Rattus norvegicus)
Mammalia Qtrtd1 33
  • 86.1 (n)
mouse
(Mus musculus)
Mammalia Qtrtd1 33 34
  • 83.9 (n)
Qtrt2 16
oppossum
(Monodelphis domestica)
Mammalia QTRTD1 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QTRTD1 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves QTRTD1 33 34
  • 68.28 (n)
lizard
(Anolis carolinensis)
Reptilia QTRTD1 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qtrtd1 33
  • 64.16 (n)
Str.7249 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15850 33
zebrafish
(Danio rerio)
Actinopterygii qtrtd1 33 34
  • 60.92 (n)
Dr.15434 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5124 33
African malaria mosquito
(Anopheles gambiae)
Insecta QTRD1_ANOGA 33
  • 46.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3434 33 34
  • 44.92 (n)
worm
(Caenorhabditis elegans)
Secernentea tgt-2 33 34
  • 43.17 (n)
rice
(Oryza sativa)
Liliopsida Os10g0141900 33
  • 45.47 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2F3.13c 33
  • 43.09 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04654 33
  • 40.65 (n)
Species where no ortholog for QTRT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QTRT2 Gene

ENSEMBL:
Gene Tree for QTRT2 (if available)
TreeFam:
Gene Tree for QTRT2 (if available)

Paralogs for QTRT2 Gene

Paralogs for QTRT2 Gene

genes like me logo Genes that share paralogs with QTRT2: view

Variants for QTRT2 Gene

Sequence variations from dbSNP and Humsavar for QTRT2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000030638 -- 114,070,244(+) A/G intron_variant
rs1000304967 -- 114,064,848(+) A/G intron_variant
rs1000527576 -- 114,075,351(+) C/T intron_variant
rs1000602419 -- 114,056,069(+) A/G upstream_transcript_variant
rs1000639549 -- 114,075,521(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for QTRT2 Gene

Variant ID Type Subtype PubMed ID
esv3597449 CNV loss 21293372

Variation tolerance for QTRT2 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for QTRT2 Gene

Human Gene Mutation Database (HGMD)
QTRT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
QTRT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QTRT2 Gene

Disorders for QTRT2 Gene

No disorders were found for QTRT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QTRT2 Gene

Publications for QTRT2 Gene

  1. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. (PMID: 20354154) Chen YC … Garcia GA (RNA (New York, N.Y.) 2010) 2 3 4 22 58
  2. Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. (PMID: 19414587) Boland C … Kelly VP (The Journal of biological chemistry 2009) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for QTRT2 Gene

Sources for QTRT2 Gene

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