 |
 | Services
| |
 |
Aliases & Descriptions for QTRT1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.4.2.29 3 | | FP3235 2 | | TGT 1, 2, 3, 5 | | TGUT 3 |
| | | Descriptions |
|---|
| Guanine insertion enzyme 3 | | queuine tRNA-ribosyltransferase 1 2 | | tRNA-guanine transglycosylase 2, 3 |
|
| | Search outside databases for aliases for QTRT1 genePrevious GC identifers: GC19P010674 GC19P010675 |
Summaries for QTRT1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for QTRT1: tRNA-guanine transglycosylase (TGT; EC 2.4.2.29) synthesizes queuosine (Q), which is found in tRNAs that recognize NAU and NAC codons, encoding tyr, asn, asp, and his. Prokaryotic TGT is a single protein of 43 kD. In contrast, mammalian TGT appears to be a heterodimer consisting of a 60-kD subunit (USP14; MIM 607274) and a 43-kD catalytic subunit (QTRT1) (Deshpande and Katze, 2001 [PubMed 11255023]).[supplied by OMIM] UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0Function: Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) |
Genomic Location for QTRT1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the QTRT1 gene 
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3QTRT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P010676:
(about GC identifiers)
Start:
|
10,673,131 bp from pter |
End:
|
10,685,040 bp from pter |
Size:
|
11,910 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for QTRT1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0 (See
protein sequence)Recommended Name: Queuine tRNA-ribosyltransferase Size: 403 amino acids; 44048 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: Q96BQ4 Q9BXQ9REFSEQ proteins: NP_112486.1
ENSEMBL proteins: ENSP00000250237
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005840 | ribosome |
NAS | -- | About this table
Antibodies for QTRT1: Assays for QTRT1: | Protein
Domains/ Families for QTRT1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BXR0
ProtoNet protein and cluster: Q9BXR0 1 Blocks protein family: IPB002616 Queuine/other tRNA-ribosyltransferase
UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0Similarity: Belongs to the queuine tRNA-ribosyltransferase family | Gene Function for QTRT1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031209
Applied Biosystems Silencer® siRNAs for QTRT1
Sigma-Aldrich siRNA for QTRT1  Sigma-Aldrich shRNA for QTRT1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_031209                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_031209                                  untagged cDNA clone in CMV expression vector: NM_031209 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_031209
UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0Function: Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)Catalytic activity: [tRNA]-guanine + queuine = [tRNA]-queuine + guanineCatalytic activity: [tRNA]-guanine + 7-aminomethyl-7-carbaguanine = [tRNA]-7-aminomethyl-7-carbaguanine + guanineEnzyme Number (IUBMB): EC 2.4.2.29 4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for QTRT1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008616 | queuosine biosynthetic process |
NAS | 11255023 | About this table
|
Drugs & Compounds for QTRT1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for QTRT1 7 Novoseek chemical compound relationships for QTRT1 gene
About this table
|
Transcripts for QTRT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031209
Sigma-Aldrich siRNA for QTRT1  Sigma-Aldrich shRNA for QTRT1  Explore Sigma-Aldrich super-pooled esiRNAs 
REFSEQ mRNAs for QTRT1 gene: NM_031209.2               OriGene GFP tagged cDNA clone in CMV expression vector: NM_031209                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_031209                                  untagged cDNA clone in CMV expression vector: NM_031209  Additional cDNA sequence: AF302783.1 AF302784.1 AF302785.1 AF370379.1 AK055216.1 AK057877.1 AK225173.1 AK294166.1 AK314308.1 BC015350.1 CR602960.1 CR614822.1 CR614899.1 20 DOTS entries: DT.100027084 DT.121465724 DT.442457 DT.100699569 DT.100652329 DT.121465619 DT.121465708 DT.100027083 DT.100796387 DT.100796386 DT.40316301 DT.97845567 DT.121465747 DT.97798801 DT.121465660 DT.121465665 DT.121465685 DT.121465738 DT.121465706 DT.91997349 24/186 AceView cDNA sequences (see all 186
):CR602960 BC015350 BM756341 CB164816 AI492206 BQ929911 AL138462 BU508404 BQ894940 BF939611 AI366116 BF447204 CR614822 BM747043 BM052911 BM757226 BM719390 BM511883 BM460709 AL536012 BU621033 BU634015 AL138461 BU629648
highest scoring ESTs for QTRT1:AA514559 AA649522 AA827574 AF302783 AF302784 AI015010 AI366116 AI433680 AI492206 AI571124 Unigene Cluster for QTRT1: Queuine tRNA-ribosyltransferase 1 Hs.631638 [show with all ESTs]Unigene Representative Sequence: BM467261
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000250237
|
Expression for QTRT1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| QTRT1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for QTRT1
1 / 2 / 3 3 probe-sets matching QTRT1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TACGGGGATC
SOURCE GeneReport for Unigene cluster: Hs.631638
|
Orthologs for QTRT1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for QTRT1 gene from 5/17 species (see all 17
)
About this table Species with no ortholog for QTRT1
ENSEMBL Gene Tree for QTRT1 | Paralogs for QTRT1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for QTRT1 gene
- QTRTD12
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for QTRT1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for QTRT1 (up to first 250kb)
|
Disorders & Mutations for QTRT1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609615
1 Novoseek disease relationship for QTRT1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0.00 |
2 |
11134952 (1), 15246567 (1) |
About this table
|
Medical News for QTRT1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for QTRT1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/25 PubMed articles for QTRT1 gene (see all 25
): |
Search for QTRT1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing QTRT1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing QTRT1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QTRT1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for QTRT1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for QTRT1:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for QTRT1 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|