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Aliases for QTRT1 Gene

Aliases for QTRT1 Gene

  • Queuine TRNA-Ribosyltransferase 1 2 3
  • TRNA-Guanine Transglycosylase 2 3 4
  • Guanine Insertion Enzyme 3 4
  • EC 2.4.2.29 4 63
  • TGUT 3 4
  • TGT 3 4
  • TGT, Catalytic Subunit 3
  • TGT, 43-KD Subunit 3
  • FP3235 3

External Ids for QTRT1 Gene

Previous GeneCards Identifiers for QTRT1 Gene

  • GC19P010674
  • GC19P010675
  • GC19P010812
  • GC19P010389

Summaries for QTRT1 Gene

Entrez Gene Summary for QTRT1 Gene

  • This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]

GeneCards Summary for QTRT1 Gene

QTRT1 (Queuine TRNA-Ribosyltransferase 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA modification in the nucleus and cytosol. GO annotations related to this gene include queuine tRNA-ribosyltransferase activity. An important paralog of this gene is QTRTD1.

UniProtKB/Swiss-Prot for QTRT1 Gene

  • Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QTRT1 Gene

Genomics for QTRT1 Gene

Regulatory Elements for QTRT1 Gene

Transcription factor binding sites by QIAGEN in the QTRT1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for QTRT1 Gene

Chromosome:
19
Start:
10,701,430 bp from pter
End:
10,713,437 bp from pter
Size:
12,008 bases
Orientation:
Plus strand

Genomic View for QTRT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for QTRT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QTRT1 Gene

Proteins for QTRT1 Gene

  • Protein details for QTRT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXR0-TGT_HUMAN
    Recommended name:
    Queuine tRNA-ribosyltransferase
    Protein Accession:
    Q9BXR0
    Secondary Accessions:
    • B4DFM7
    • Q96BQ4
    • Q9BXQ9

    Protein attributes for QTRT1 Gene

    Size:
    403 amino acids
    Molecular mass:
    44048 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with QTRTD1.
    SequenceCaution:
    • Sequence=AAH15350.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for QTRT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QTRT1 Gene

Proteomics data for QTRT1 Gene at MOPED

Selected DME Specific Peptides for QTRT1 Gene

Post-translational modifications for QTRT1 Gene

  • Ubiquitination at Lys 219 and Lys 236
  • Modification sites at PhosphoSitePlus

Other Protein References for QTRT1 Gene

Domains & Families for QTRT1 Gene

Protein Domains for QTRT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXR0

UniProtKB/Swiss-Prot:

TGT_HUMAN :
  • Belongs to the queuine tRNA-ribosyltransferase family.
Family:
  • Belongs to the queuine tRNA-ribosyltransferase family.
genes like me logo Genes that share domains with QTRT1: view

No data available for Gene Families for QTRT1 Gene

Function for QTRT1 Gene

Molecular function for QTRT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Guanine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine
UniProtKB/Swiss-Prot Function:
Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity).

Enzyme Numbers (IUBMB) for QTRT1 Gene

Gene Ontology (GO) - Molecular Function for QTRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008479 queuine tRNA-ribosyltransferase activity TAS 11255023
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with QTRT1: view
genes like me logo Genes that share phenotypes with QTRT1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for QTRT1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for QTRT1 Gene

Localization for QTRT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QTRT1 Gene

Cytoplasm. Mitochondrion. Nucleus. Note=Weakly associates with mitochondria, possibly via QTRTD1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QTRT1 Gene COMPARTMENTS Subcellular localization image for QTRT1 gene
Compartment Confidence
mitochondrion 3
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for QTRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane TAS --
genes like me logo Genes that share ontologies with QTRT1: view

Pathways & Interactions for QTRT1 Gene

genes like me logo Genes that share pathways with QTRT1: view

Pathways by source for QTRT1 Gene

UniProtKB/Swiss-Prot Q9BXR0-TGT_HUMAN

  • Pathway: tRNA modification; tRNA-queuosine biosynthesis

Interacting Proteins for QTRT1 Gene

Gene Ontology (GO) - Biological Process for QTRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS 11255023
GO:0008033 tRNA processing TAS --
GO:0008616 queuosine biosynthetic process NAS 11255023
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with QTRT1: view

No data available for SIGNOR curated interactions for QTRT1 Gene

Drugs & Compounds for QTRT1 Gene

(3) Drugs for QTRT1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanine Experimental Pharma 0
7-Deazaguanine Experimental Pharma 0
Guanosine Experimental Pharma 0

(6) Additional Compounds for QTRT1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
queuine
  • 2-Amino-5-((((1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-1,7-dihydro-4H-pyrrolo(2,3-D)pyrimidin-4-one
  • 7-(3,4-trans-4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanine
  • Base Q
  • Queuine
72496-59-4
7-Aminomethyl-7-carbaguanine
  • 7-Aminomethyl-7-deazaguanine
  • PreQ1
Anticodon
Nucleoside
tRNA
genes like me logo Genes that share compounds with QTRT1: view

Transcripts for QTRT1 Gene

Unigene Clusters for QTRT1 Gene

Queuine tRNA-ribosyltransferase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for QTRT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for QTRT1 Gene

No ASD Table

Relevant External Links for QTRT1 Gene

GeneLoc Exon Structure for
QTRT1
ECgene alternative splicing isoforms for
QTRT1

Expression for QTRT1 Gene

mRNA expression in normal human tissues for QTRT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for QTRT1 Gene



SOURCE GeneReport for Unigene cluster for QTRT1 Gene Hs.631638

genes like me logo Genes that share expression patterns with QTRT1: view

Protein tissue co-expression partners for QTRT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for QTRT1 Gene

Orthologs for QTRT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QTRT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia QTRT1 35
  • 87.26 (n)
  • 93.3 (a)
QTRT1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QTRT1 35
  • 89.8 (n)
  • 94.78 (a)
QTRT1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qtrt1 35
  • 83.75 (n)
  • 87.31 (a)
Qtrt1 16
Qtrt1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia QTRT1 35
  • 99.75 (n)
  • 100 (a)
QTRT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Qtrt1 35
  • 84.25 (n)
  • 87.81 (a)
oppossum
(Monodelphis domestica)
Mammalia QTRT1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QTRT1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QTRT1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76136 35
qtrt1 35
  • 68.48 (n)
  • 75.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7586 35
zebrafish
(Danio rerio)
Actinopterygii qtrt1 35
  • 68.34 (n)
  • 72.61 (a)
zgc66378 35
qtrt1 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003622 35
  • 63.16 (n)
  • 58.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tgt 35
  • 62.69 (n)
  • 59.59 (a)
Tgt 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tgt-1 35
  • 52.19 (n)
  • 55.23 (a)
tgt-1 36
  • 51 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.32882 35
Os09g0469900 35
  • 56.93 (n)
  • 58.18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.603 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07015 35
  • 58.84 (n)
  • 58.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1687.19c 35
  • 53.85 (n)
  • 57.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5170 36
  • 61 (a)
OneToOne
Species with no ortholog for QTRT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QTRT1 Gene

ENSEMBL:
Gene Tree for QTRT1 (if available)
TreeFam:
Gene Tree for QTRT1 (if available)

Paralogs for QTRT1 Gene

Paralogs for QTRT1 Gene

Pseudogenes.org Pseudogenes for QTRT1 Gene

genes like me logo Genes that share paralogs with QTRT1: view

Variants for QTRT1 Gene

Sequence variations from dbSNP and Humsavar for QTRT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs892085 -- 10,707,416(-) TCCCA(C/T)CACAT intron-variant
rs4425006 -- 10,702,688(+) AAATA(C/T)CTGTT intron-variant
rs4804520 -- 10,700,991(+) cactg(C/T)gcccg upstream-variant-2KB
rs6511709 -- 10,711,602(+) gacca(A/C)aggcg intron-variant
rs7251206 -- 10,702,639(+) tctct(A/C)ccaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QTRT1 Gene

Variant ID Type Subtype PubMed ID
nsv833745 CNV Loss 17160897
nsv911047 CNV Loss 21882294
nsv833746 CNV Loss 17160897

Variation tolerance for QTRT1 Gene

Residual Variation Intolerance Score: 10.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for QTRT1 Gene

HapMap Linkage Disequilibrium report
QTRT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QTRT1 Gene

Disorders for QTRT1 Gene

Relevant External Links for QTRT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QTRT1
genes like me logo Genes that share disorders with QTRT1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QTRT1 Gene

Publications for QTRT1 Gene

  1. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. (PMID: 20354154) Chen Y.C. … Garcia G.A. (RNA 2010) 2 23 67
  2. How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase. (PMID: 19894214) Ritschel T. … Klebe G. (ChemMedChem 2009) 23 67
  3. Structure-based drug design: exploring the proper filling of apolar pockets at enzyme active sites. (PMID: 18510366) ZA1rcher M. … Diederich F. (J. Org. Chem. 2008) 23 67
  4. FTree query construction for virtual screening: a statistical analysis. (PMID: 18217214) Gerlach C. … Zaliani A. (J. Comput. Aided Mol. Des. 2008) 23 67
  5. Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding. (PMID: 17902085) HAPrtner S.R. … Diederich F. (Angew. Chem. Int. Ed. Engl. 2007) 23 67

Products for QTRT1 Gene

Sources for QTRT1 Gene

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