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QTRT1 Gene

protein-coding   GIFtS: 52
GCID: GC19P010812

Queuine TRNA-Ribosyltransferase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Queuine TRNA-Ribosyltransferase 11 2     EC 2.4.2.293 8
TRNA-Guanine Transglycosylase1 2 3     FP32352
TGT2 3 5     Queuine TRNA-Ribosyltransferase2
Guanine Insertion Enzyme2 3     TGT, 43-KD Subunit2
TGUT2 3     TGT, Catalytic Subunit2

External Ids:    HGNC: 237971   Entrez Gene: 818902   Ensembl: ENSG000002133397   OMIM: 6096155   UniProtKB: Q9BXR03   

Export aliases for QTRT1 gene to outside databases

Previous GC identifers: GC19P010674 GC19P010675 GC19P010676 GC19P010389


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for QTRT1 Gene:
This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a
heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine
queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene
of this gene is located on the long arm of chromosome X. (provided by RefSeq, Feb 2012)

GeneCards Summary for QTRT1 Gene:
QTRT1 (queuine tRNA-ribosyltransferase 1) is a protein-coding gene. GO annotations related to this gene include queuine tRNA-ribosyltransferase activity. An important paralog of this gene is QTRTD1.

UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0
Function: Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine
for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby
forming the hypermodified nucleoside queuosine (Q)
(7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the QTRT1 gene promoter:
         AP-1   ATF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQTRT1 promoter sequence
   Search Chromatin IP Primers for QTRT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat QTRT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3

QTRT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QTRT1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010812:  view genomic region     (about GC identifiers)

Start:
10,812,106 bp from pter      End:
10,824,113 bp from pter
Size:
12,008 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0 (See protein sequence)
Recommended Name: Queuine tRNA-ribosyltransferase  
Size: 403 amino acids; 44048 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with QTRTD1 (By similarity)
Sequence caution: Sequence=AAH15350.1; Type=Erroneous initiation;
Secondary accessions: Q96BQ4 Q9BXQ9

Explore the universe of human proteins at neXtProt for QTRT1: NX_Q9BXR0

Explore proteomics data for QTRT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys219, Lys236
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for QTRT1 (Q9BXR0) (see all 6)
     LGNTYHL  LTDSGGFQ  FMPVGTQA  TPVFMPVGT 


    See QTRT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112486.1  
    ENSEMBL proteins: 
     ENSP00000250237   ENSP00000389126   ENSP00000464990   ENSP00000468811   ENSP00000467394  
     ENSP00000465974  

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    Cloud-Clone Corp. Proteins for QTRT1

     
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    Search eBioscience for ELISAs for QTRT1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002616 tRNA_ribo_trans-like
     IPR004803 Queuine_tRNA-ribosylTrfase

    Graphical View of Domain Structure for InterPro Entry Q9BXR0

    ProtoNet protein and cluster: Q9BXR0

    1 Blocks protein domain: IPB002616 Queuine/other tRNA-ribosyltransferase

    UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0
    Similarity: Belongs to the queuine tRNA-ribosyltransferase family


    Find genes that share domains with QTRT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TGT_HUMAN, Q9BXR0
    Function: Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine
    for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby
    forming the hypermodified nucleoside queuosine (Q)
    (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
    Catalytic activity: Guanine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine

         Enzyme Number (IUBMB): EC 2.4.2.291 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008479queuine tRNA-ribosyltransferase activity TAS11255023
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with QTRT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for QTRT1:
     Small cells 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Qtrt1):
     cellular  homeostasis/metabolism 

    Find genes that share phenotypes with QTRT1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for QTRT1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for QTRT1
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    miRNA
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    miRTarBase miRNAs that target QTRT1:
    hsa-mir-92a-3p (MIRT048956)

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    Predesigned siRNA for gene silencing in human, mouse, rat QTRT1

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    OriGene ORF clones in mouse, rat for QTRT1
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    GenScript: all cDNA clones in your preferred vector: QTRT1 (NM_031209)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QTRT1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QTRT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TGT_HUMAN, Q9BXR0: Cytoplasm (By similarity). Mitochondrion (By similarity). Nucleus (By similarity).
    Note=Weakly associates with mitochondria, possibly via QTRTD1 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    cytoskeleton1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005840ribosome ----

    Find genes that share ontologies with QTRT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: TGT_HUMAN, Q9BXR0
    Pathway: tRNA modification; tRNA-queuosine biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for QTRT1
    Interactions:

        Search GeneGlobe Interaction Network for QTRT1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for QTRT1 (Q9BXR03 ENSP000002502374) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARF6P623303, ENSP000002983164I2D: score=1 STRING: ENSP00000298316
    COPS6Q7L5N13I2D: score=4 
    NDUFA4L2Q9NRX33I2D: score=4 
    SETDB1Q150473I2D: score=4 
    SH3GL3Q999633I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006400tRNA modification TAS11255023
    GO:0008033tRNA processing ----
    GO:0008616queuosine biosynthetic process NAS11255023

    Find genes that share ontologies with QTRT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for QTRT1 (TGT)

    3 HMDB Compounds for QTRT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    7-Aminomethyl-7-carbaguanine7-aminomethyl-7-deazaguanine (see all 2)----
    GuanineGUN (see all 26)73-40-5--
    Queuine2-amino-5-((((1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-1,7-dihydro-4H-pyrrolo(2,3-d)pyrimidin-4-one (see all 4)72496-59-4--

    8 Novoseek inferred chemical compound relationships for QTRT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    queuine 95.9 12 20354154 (2), 12877882 (1), 7630726 (1), 15246567 (1) (see all 6)
    trna guanine 94.5 2 7630726 (1), 12581659 (1)
    7-deazaguanine 86.1 1 9369241 (1)
    trna 71.1 12 1378304 (2), 11134952 (2), 16206323 (1), 7630726 (1) (see all 5)
    guanine 69.8 19 20354154 (3), 12877882 (2), 1378304 (2), 11255023 (2) (see all 8)
    anticodon 57.8 1 7630726 (1)
    guanosine 47.3 2 15246567 (1)
    nucleoside 42.7 4 11134952 (1), 15246567 (1)



    Find genes that share compounds with QTRT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for QTRT1 gene: 
    NM_031209.2  

    Unigene Cluster for QTRT1:

    Queuine tRNA-ribosyltransferase 1
    Hs.631638  [show with all ESTs]
    Unigene Representative Sequence: BM467261
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589488 ENST00000250237(uc002mpr.3) ENST00000585885 ENST00000590705
    ENST00000421333 ENST00000587599 ENST00000592254 ENST00000591643 ENST00000587861
    ENST00000592376 ENST00000587500 ENST00000592531
    miRNA
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    GenScript: all cDNA clones in your preferred vector: QTRT1 (NM_031209)
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      QuantiTect SYBR Green Assays in human, mouse, rat QTRT1
      QuantiFast Probe-based Assays in human, mouse, rat QTRT1

    Additional mRNA sequence: 

    AF302783.1 AF302784.1 AF302785.1 AK055216.1 AK057877.1 AK225173.1 AK314308.1 BC015350.1 

    20 DOTS entries:

    DT.100027084  DT.121465724  DT.442457  DT.100699569  DT.121465619  DT.100652329  DT.121465708  DT.100027083 
    DT.100796387  DT.100796386  DT.40316301  DT.97845567  DT.121465747  DT.97798801  DT.121465660  DT.121465665 
    DT.121465685  DT.121465738  DT.121465706  DT.91997349 

    Selected AceView cDNA sequences (see all 186):

    CR614822 CK429604 BM757226 AI685059 CR614899 AK055216 BU629648 AI366116 
    BU621033 AL138462 BQ007721 BX423123 AA378418 BF939611 BU634015 BM661684 
    BM052911 BM511883 BQ718392 AL138461 AW338726 AI492206 BX113603 F27177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    QTRT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACGGGGATC
    QTRT1 Expression
    About this image


    QTRT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Ovary (Reproductive System)
    QTRT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    QTRT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631638
        Custom PCR Arrays for QTRT1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QTRT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for QTRT1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Qtrt11 , 5 queuine tRNA-ribosyltransferase 11, 5 83.75(n)1
    87.31(a)1
      9 (7.79 cM)5
    605071  NM_021888.21  NP_068688.21 
     214118375 
    lizard
    (Anolis carolinensis)
    Reptilia QTRT16
    queuine tRNA-ribosyltransferase 1
    72(a)
    1 ↔ 1
    2(80672339-80685874)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.75862 Xenopus laevis transcribed sequence with moderate similarity more 76.19(n)    BX844196.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663782 similar to queuine tRNA-ribosyltransferase 1 75.51(n)   393985  BC054695.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tgt1 tRNA-guanine transglycosylase 62.69(n)
    59.59(a)
      33307  NM_134741.3  NP_608585.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tgt-11 tgt-1 52.19(n)
    55.23(a)
      178131  NM_069867.4  NP_502268.1 
    rice
    (Oryza sativa)
    Liliopsida Os.328822 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.59(n)    AK064033.1 


    ENSEMBL Gene Tree for QTRT1 (if available)
    TreeFam Gene Tree for QTRT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for QTRT1 gene
    QTRTD12  
    Selected SIMAP similar genes for QTRT1 using alignment to 7 protein entries:     TGT_HUMAN (see all proteins) (see all similar genes):
    CNOT2    MKRN1    ECD    NDUFS7    ZNF738    LRTOMT
    C12orf23    KLHDC1    TGFBR3    NSD1    NSRP1    LRRC36
    SENP7    COX7A2    NPAT    PSD3    ATL2    FAM221A

    Find genes that share paralogs with QTRT1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for QTRT1
    PGOHUM00000241955


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for QTRT1 (see all 317)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823550571,2
    --10810142(+) CTGGGA/CAGCAG 1 -- us2k10--------
    rs1878914081,2
    --10810188(+) GCCGGA/GTGTGG 1 -- us2k10--------
    rs352878501,2
    C,F--10810328(+) AAAAA-/A/AAA 
            
    GAAGA
    2 -- us2k1 cds12NA CSA 4
    rs1925713811,2
    --10810386(+) TGAGTA/GTTGTA 1 -- us2k10--------
    rs775758451,2
    --10810449(+) TTTTCC/TAGGCG 1 -- us2k10--------
    rs752717031,2
    C--10810605(+) CTTCTA/GGGACA 1 -- us2k10--------
    rs1166311951,2
    C--10810657(+) GTAATG/TATAAC 1 -- us2k10--------
    rs1872883671,2
    --10810765(+) TCACTA/GCAGCC 1 -- us2k10--------
    rs1922693681,2
    --10810841(+) TGCCAC/TCACAC 1 -- us2k10--------
    rs1409058591,2
    --10811188(+) TTTTAA/GTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for QTRT1 (10812106 - 10824113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for QTRT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911047CNV Loss21882294
    nsv833746CNV Loss17160897
    nsv833745CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing QTRT1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609615    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for QTRT1:
    Shigellosis

    Find genes that share disorders with QTRT1           About GenesLikeMe

    1 Novoseek inferred disease relationship for QTRT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 2 11134952 (1), 15246567 (1)


    Export disorders for QTRT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for QTRT1 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with QTRT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA encoding the human tRNA-guanine transglycosylase (TGT) catalytic subunit. (PubMed id 11255023)1, 2, 9 Deshpande K.L. and Katze J.R. (Gene 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. (PubMed id 20354154)1, 9 Chen Y.C....Garcia G.A. (RNA 2010)
    4. Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor. (PubMed id 23704982)1 Biela I....Reuter K. (PLoS ONE 2013)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Differential heterocyclic substrate recognition by, and pteridine inhibition of E. coli and human tRNA-guanine transglycosylases. (PubMed id 21640076)1 Eric Thomas C....Garcia G.A. (Biochem. Biophys. Res. Commun. 2011)
    9. Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases. (PubMed id 21131277)1 Chen Y.C....Garcia G.A. (Nucleic Acids Res. 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 81890 HGNC: 23797 AceView: QTRT1 Ensembl:ENSG00000213339 euGenes: HUgn81890
    ECgene: QTRT1 H-InvDB: QTRT1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for QTRT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for QTRT1 gene:
    Search GeneIP for patents involving QTRT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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