Aliases for QTRT1 Gene
External Ids for QTRT1 Gene
Previous GeneCards Identifiers for QTRT1 Gene
This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
GeneCards Summary for QTRT1 Gene
QTRT1 (Queuine TRNA-Ribosyltransferase Catalytic Subunit 1) is a Protein Coding gene. Diseases associated with QTRT1 include colon adenocarcinoma. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include queuine tRNA-ribosyltransferase activity. An important paralog of this gene is QTRT2.
UniProtKB/Swiss-Prot for QTRT1 Gene
Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity).