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Aliases for QTRT1 Gene

Aliases for QTRT1 Gene

  • Queuine TRNA-Ribosyltransferase Catalytic Subunit 1 2 3 5
  • TRNA-Guanine Transglycosylase 2 3 4
  • Queuine TRNA-Ribosyltransferase 1 2 3
  • Guanine Insertion Enzyme 3 4
  • EC 2.4.2.29 4 61
  • TGUT 3 4
  • TGT 3 4
  • TGT, Catalytic Subunit 3
  • TGT, 43-KD Subunit 3
  • FP3235 3

External Ids for QTRT1 Gene

Previous GeneCards Identifiers for QTRT1 Gene

  • GC19P010674
  • GC19P010675
  • GC19P010812
  • GC19P010389

Summaries for QTRT1 Gene

Entrez Gene Summary for QTRT1 Gene

  • This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]

GeneCards Summary for QTRT1 Gene

QTRT1 (Queuine TRNA-Ribosyltransferase Catalytic Subunit 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include queuine tRNA-ribosyltransferase activity. An important paralog of this gene is QTRT2.

UniProtKB/Swiss-Prot for QTRT1 Gene

  • Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1 of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1 of the ribose to form the product (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QTRT1 Gene

Genomics for QTRT1 Gene

Regulatory Elements for QTRT1 Gene

Enhancers for QTRT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010717 1.7 FANTOM5 ENCODE dbSUPER 19.7 +17.7 17726 3.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 EIF3G FBXL12 RAVER1 QTRT1 ZNF627 ILF3-AS1 LOC100419831 SLC44A2 PRKCSH SWSAP1
GH19G010725 1.2 dbSUPER 20 +24.3 24283 0.7 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF627 LOC100419831 ILF3-AS1 RAVER1 QTRT1 SLC44A2 TIMM29 FBXL12 CDC37 YIPF2
GH19G010726 1.2 ENCODE dbSUPER 20 +25.4 25350 1.1 CREB3L1 ZNF121 ELK1 ZNF592 SMARCA4 KDM1A LEF1 ZNF777 ZNF175 BACH1 ILF3-AS1 QTRT1 ZNF627 LOC100419831 SMARCA4 SLC44A2 PIR47140 MIR4748
GH19G010834 1.2 ENCODE 19.8 +134.6 134596 2.4 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D ZNF441 ZNF491 ILF3-AS1 ZNF627 QTRT1 EIF3G RAVER1 TIMM29 ICAM1 SMARCA4
GH19G010601 1.7 FANTOM5 ENCODE dbSUPER 11.5 -97.3 -97307 4.4 ARID4B DMAP1 ZNF2 ZNF766 ZNF143 SP3 SP5 REST TBX21 ZNF610 SLC44A2 CDKN2D KRI1 ICAM3 ILF3 QTRT1 ZNF627 PRKCSH RPL10P15 ILF3-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around QTRT1 on UCSC Golden Path with GeneCards custom track

Promoters for QTRT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107065 271 1400 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Transcription factor binding sites by QIAGEN in the QTRT1 gene promoter:

Genomic Location for QTRT1 Gene

Chromosome:
19
Start:
10,701,430 bp from pter
End:
10,713,437 bp from pter
Size:
12,008 bases
Orientation:
Plus strand

Genomic View for QTRT1 Gene

Genes around QTRT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QTRT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QTRT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QTRT1 Gene

Proteins for QTRT1 Gene

  • Protein details for QTRT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXR0-TGT_HUMAN
    Recommended name:
    Queuine tRNA-ribosyltransferase catalytic subunit 1
    Protein Accession:
    Q9BXR0
    Secondary Accessions:
    • B4DFM7
    • Q96BQ4
    • Q9BXQ9

    Protein attributes for QTRT1 Gene

    Size:
    403 amino acids
    Molecular mass:
    44048 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
    SequenceCaution:
    • Sequence=AAH15350.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for QTRT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QTRT1 Gene

Selected DME Specific Peptides for QTRT1 Gene

Q9BXR0:
  • FMPVGTQA
  • LGNTYHL
  • IQNALGSDI
  • KPRYLMGVG
  • TPVFMPVGT
  • LTDSGGFQ

Post-translational modifications for QTRT1 Gene

  • Ubiquitination at Lys219 and isoforms=236
  • Modification sites at PhosphoSitePlus

Other Protein References for QTRT1 Gene

Domains & Families for QTRT1 Gene

Protein Domains for QTRT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXR0

UniProtKB/Swiss-Prot:

TGT_HUMAN :
  • Belongs to the queuine tRNA-ribosyltransferase family.
Family:
  • Belongs to the queuine tRNA-ribosyltransferase family.
genes like me logo Genes that share domains with QTRT1: view

No data available for Gene Families for QTRT1 Gene

Function for QTRT1 Gene

Molecular function for QTRT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.34 uM for tRNA(Tyr) {ECO:0000269 PubMed:20354154}; KM=0.41 uM for guanine {ECO:0000269 PubMed:20354154}; Note=kcat is 0.0056 sec(-1) with tRNA(Tyr) as substrate and 0.00586 sec(-1) with guanine as substrate. {ECO:0000269 PubMed:20354154};
UniProtKB/Swiss-Prot CatalyticActivity:
Guanine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1 of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1 of the ribose to form the product (By similarity).

Enzyme Numbers (IUBMB) for QTRT1 Gene

Gene Ontology (GO) - Molecular Function for QTRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008479 queuine tRNA-ribosyltransferase activity TAS 11255023
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0016763 transferase activity, transferring pentosyl groups IEA --
GO:0042803 protein homodimerization activity IDA 20354154
genes like me logo Genes that share ontologies with QTRT1: view
genes like me logo Genes that share phenotypes with QTRT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for QTRT1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QTRT1 Gene

Localization for QTRT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QTRT1 Gene

Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Weakly associates with mitochondria, possibly via QTRT2. {ECO:0000255 HAMAP-Rule:MF_03218}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QTRT1 gene
Compartment Confidence
mitochondrion 5
nucleus 4
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for QTRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with QTRT1: view

Pathways & Interactions for QTRT1 Gene

genes like me logo Genes that share pathways with QTRT1: view

Pathways by source for QTRT1 Gene

Gene Ontology (GO) - Biological Process for QTRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS,IEA 11255023
GO:0008033 tRNA processing IEA --
GO:0008616 queuosine biosynthetic process NAS,ISS --
GO:0101030 tRNA-guanine transglycosylation NAS,IEA 11255023
genes like me logo Genes that share ontologies with QTRT1: view

No data available for SIGNOR curated interactions for QTRT1 Gene

Drugs & Compounds for QTRT1 Gene

(3) Drugs for QTRT1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanine Experimental Pharma 0

(6) Additional Compounds for QTRT1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
queuine
  • 2-Amino-5-((((1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-1,7-dihydro-4H-pyrrolo(2,3-D)pyrimidin-4-one
  • 7-(3,4-trans-4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanine
  • Base Q
  • Queuine
72496-59-4
7-Aminomethyl-7-carbaguanine
  • 7-Aminomethyl-7-deazaguanine
  • PreQ1
genes like me logo Genes that share compounds with QTRT1: view

Transcripts for QTRT1 Gene

Unigene Clusters for QTRT1 Gene

Queuine tRNA-ribosyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for QTRT1 Gene

No ASD Table

Relevant External Links for QTRT1 Gene

GeneLoc Exon Structure for
QTRT1
ECgene alternative splicing isoforms for
QTRT1

Expression for QTRT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QTRT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for QTRT1 Gene



Protein tissue co-expression partners for QTRT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of QTRT1 Gene:

QTRT1

SOURCE GeneReport for Unigene cluster for QTRT1 Gene:

Hs.631638

Evidence on tissue expression from TISSUES for QTRT1 Gene

  • Nervous system(4.7)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with QTRT1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QTRT1 Gene

Orthologs for QTRT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QTRT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QTRT1 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia QTRT1 34 35
  • 89.8 (n)
cow
(Bos Taurus)
Mammalia QTRT1 34 35
  • 87.26 (n)
rat
(Rattus norvegicus)
Mammalia Qtrt1 34
  • 84.25 (n)
mouse
(Mus musculus)
Mammalia Qtrt1 34 16 35
  • 83.75 (n)
oppossum
(Monodelphis domestica)
Mammalia QTRT1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QTRT1 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QTRT1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qtrt1 34
  • 68.48 (n)
MGC76136 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7586 34
zebrafish
(Danio rerio)
Actinopterygii qtrt1 34 35
  • 68.34 (n)
zgc66378 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003622 34
  • 63.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tgt 34 35
  • 62.69 (n)
worm
(Caenorhabditis elegans)
Secernentea tgt-1 34 35
  • 52.19 (n)
rice
(Oryza sativa)
Liliopsida Os09g0469900 34
  • 56.93 (n)
Os.32882 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5170 35
  • 61 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07015 34
  • 58.84 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1687.19c 34
  • 53.85 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.603 34
Species where no ortholog for QTRT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QTRT1 Gene

ENSEMBL:
Gene Tree for QTRT1 (if available)
TreeFam:
Gene Tree for QTRT1 (if available)

Paralogs for QTRT1 Gene

Paralogs for QTRT1 Gene

Pseudogenes.org Pseudogenes for QTRT1 Gene

genes like me logo Genes that share paralogs with QTRT1: view

Variants for QTRT1 Gene

Sequence variations from dbSNP and Humsavar for QTRT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000521237 -- 10,702,605(+) TGGAG(A/G)CCAGC intron-variant
rs1000553750 -- 10,702,390(+) AAAGC(-/G)GGGGT intron-variant
rs1000772615 -- 10,709,574(+) CGGGC(C/G)TGGTG intron-variant
rs1000888700 -- 10,713,766(+) TTTTT(C/T)TTTTT downstream-variant-500B
rs1000919915 -- 10,713,480(+) TGTGG(C/T)AGCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for QTRT1 Gene

Variant ID Type Subtype PubMed ID
nsv1061882 CNV gain 25217958
nsv1160584 CNV deletion 26073780
nsv1160585 CNV deletion 26073780
nsv833745 CNV loss 17160897
nsv833746 CNV loss 17160897

Variation tolerance for QTRT1 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for QTRT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
QTRT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QTRT1 Gene

Disorders for QTRT1 Gene

Relevant External Links for QTRT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QTRT1

No disorders were found for QTRT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QTRT1 Gene

Publications for QTRT1 Gene

  1. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. (PMID: 20354154) Chen Y.C. … Garcia G.A. (RNA 2010) 2 3 4 22 64
  2. Characterization of cDNA encoding the human tRNA-guanine transglycosylase (TGT) catalytic subunit. (PMID: 11255023) Deshpande K.L. … Katze J.R. (Gene 2001) 3 4 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for QTRT1 Gene

Sources for QTRT1 Gene

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