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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

QSOX2 Gene

protein-coding GIFtS: 53
GCID: GC09M139098

Quiescin Q6 Sulfhydryl Oxidase 2

(Previous name: quiescin Q6-like 1)
(Previous symbol: QSCN6L1)

Microbiology & Infectious Diseases Congress

3 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Quiescin Q6 Sulfhydryl Oxidase 2¹ ²		Neuroblastoma-Derived Sulfhydryl Oxidase² ³
QSCN6L1¹ ² ³		Quiescin Q6-Like Protein 1² ³
SOXN² ³ ⁵		Sulfhydryl Oxidase 2²
Quiescin Q6-Like 1¹ ²		EC 1.8.3.2³

External Ids:	HGNC: 30249¹	Entrez Gene: 169714²	Ensembl: ENSG00000165661⁷	OMIM: 612860⁵	UniProtKB: Q6ZRP7³

Export aliases for QSOX2 gene to outside databases

Previous GC identifers: GC09M138239 GC09M137879 GC09M108562

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for QSOX2 Gene:

QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization

of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 (PubMed

14633699)).(supplied by OMIM, Jun 2009)

GeneCards Summary for QSOX2 Gene:

QSOX2 (quiescin Q6 sulfhydryl oxidase 2) is a protein-coding gene. Diseases associated with QSOX2 include neuroblastoma, and skin disease. GO annotations related to this gene include thiol oxidase activity. An important paralog of this gene is QSOX1.

UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7

Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction

of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also

seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NT_019501.13 NC_018920.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the QSOX2 gene promoter:
SRF USF1 NF-1 Sp1 p53 SRF (504 AA) AP-4 CUTL1 HNF-4alpha1 USF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: QSOX2 promoter sequence

Search SABiosciences Chromatin IP Primers for QSOX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QSOX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3

QSOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QSOX2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M139098: view genomic region (about GC identifiers)

Start:	139,098,179 bp from pter	End:	139,137,687 bp from pter
Size:	39,509 bases	Orientation:	minus strand

1 alternative location:

Chr9-,NW_003315926 433-798

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7 (See protein sequence)

Recommended Name: Sulfhydryl oxidase 2 precursor

Size: 698 amino acids; 77529 Da

Cofactor: Binds 1 FAD per subunit (Potential)

Subcellular location: Membrane; Single-pass membrane protein. Secreted. Cell membrane; Single-pass membrane protein

(Potential). Nucleus membrane; Single-pass membrane protein (Potential). Note=Seems to be predominantly targeted to

the nuclear and outer plasma membrane

Sequence caution: Sequence=BAC87262.1; Type=Erroneous initiation; Sequence=CAC85331.1; Type=Frameshift; Positions=354,

369, 616, 618;

Secondary accessions: A2CEE0 A6NLB0 Q5TB37 Q7Z7B6 Q86VV7 Q8N3G2

Explore the universe of human proteins at neXtProt for QSOX2: NX_Q6ZRP7

Explore proteomics data for QSOX2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q6ZRP7

QSOX2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_859052.3

ENSEMBL proteins:

ENSP00000351536 ENSP00000389089

Human Recombinant Protein Products for QSOX2:

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	Cloud-Clone Corp. Proteins for QSOX2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0031965	nuclear membrane	IEA	--

QSOX2 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro protein domains:

IPR017905 ERV/ALR_sulphydryl_oxidase

IPR012336 Thioredoxin-like_fold

IPR006863 Evr1_Alr

IPR013766 Thioredoxin_domain

Graphical View of Domain Structure for InterPro Entry Q6ZRP7

ProtoNet protein and cluster: Q6ZRP7

2 Blocks protein domains:

IPB006662 Thioredoxin type domain

IPB006863 Erv1/Alr

UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7

Similarity: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family

Similarity: Contains 1 ERV/ALR sulfhydryl oxidase domain

Similarity: Contains 1 thioredoxin domain

QSOX2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: QSOX2_HUMAN, Q6ZRP7

Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction

of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also

seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis

Catalytic activity: 2 R'C(R)SH + O(2) = R'C(R)S-S(R)CR' + H(2)O(2)

Enzyme Number (IUBMB): EC 1.8.3.2¹

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016972	thiol oxidase activity	IEA	--

QSOX2 for ontologies About GeneDecksing

Animal Models:

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miRNA Products:		miRTarBase miRNAs that target QSOX2: hsa-mir-125b (MIRT004986)


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		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate QSOX2 (see all 18):
		hsa-miR-320a hsa-miR-607 hsa-miR-125a-5p hsa-miR-605 hsa-miR-500a hsa-miR-105 hsa-miR-125b hsa-miR-103a-2*

		SwitchGear 3'UTR luciferase reporter plasmid: QSOX2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QSOX2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for QSOX2

3 Interacting proteins for QSOX2 (Q6ZRP7³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATG2A	Q2TAZ0³	I2D: score=1
CAMKK2	Q96RR4³	I2D: score=1
CLN3	Q13286³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045454	cell redox homeostasis	IEA	--
GO:0055114	oxidation-reduction process	--	--

QSOX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

QSOX2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for QSOX2

3 HMDB Compounds for QSOX2 About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

3 Novoseek inferred chemical compound relationships for QSOX2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
flavin	66.1	2	19397338 (1), 15683237 (1)
dithiothreitol	65.3	2	15568811 (1), 19409596 (1)
h2o2	46.9	1	12202243 (1)

Search CenterWatch for drugs/clinical trials and news about QSOX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for QSOX2 gene:

NM_181701.3

Unigene Cluster for QSOX2:

Quiescin Q6 sulfhydryl oxidase 2

Hs.144073 [show with all ESTs]

Unigene Representative Sequence: AJ318051

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000358701(uc010nbi.2) ENST00000455222

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat QSOX2
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate QSOX2 (see all 18):
		hsa-miR-320a hsa-miR-607 hsa-miR-125a-5p hsa-miR-605 hsa-miR-500a hsa-miR-105 hsa-miR-125b hsa-miR-103a-2*

		SwitchGear 3'UTR luciferase reporter plasmid: QSOX2 3' UTR sequence

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Clone Products:		OriGene clones in human, mouse for QSOX2 (see all 5) OriGene ORF clones in mouse, rat for QSOX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QSOX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QSOX2

Additional mRNA sequence:

AJ318051.1 AJ420461.1 AK128077.1 AK128750.1 AL834369.1 BC047604.2

6 DOTS entries:

DT.110458 DT.97836908 DT.97775695 DT.40213602 DT.75100956 DT.121194112

24/91 AceView cDNA sequences (see all 91):

AI742021 BE349598 AI028313 BE875636 BI492379 AI280985 BQ187181 CR601649

H08428 AI304528 AA514465 AI309245 AI753180 AA493143 AK128077 AA834579

BM352043 BQ894697 BQ953575 AL834369 AA325875 AW515514 BU175119 AI056976

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for QSOX2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b
SP1:															-		-										-				-
SP2:																	-										-				-
SP3:																											-				-
SP4:
SP5:							-		-						-		-

ECgene alternative splicing isoforms for QSOX2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

QSOX2 expression in normal human tissues (normalized intensities) QSOX2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAATGTCAG

About this image

QSOX2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/21 selected tissues (see all 21) fully expand


Testis (Reproductive System) fully expand to see all 4 entries
Leydig Cells Testis Interstitium
seminal vesicle ; glandular cells

Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Reproductive System (Reproductive System) fully expand to see all 4 entries
uterus, post-menopause ; glandular cells

Tonsil
tonsil ; squamous epithelial cells

Pancreas (Endocrine System) fully expand to see all 2 entries
Islets of Langerhans
pancreas ; exocrine glandular cells

See QSOX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for QSOX2

SOURCE GeneReport for Unigene cluster: Hs.144073

UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7

Tissue specificity: Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung,

liver and skeletal muscles

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for QSOX2 gene from 7/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Qsox2^{1 , 5}	quiescin Q6 sulfhydryl oxidase 2^{1, 5}	81.69(n)¹ 82.57(a)¹		2 (18.45 cM)⁵ 227638¹ NM_153559.2¹ NP_705787.1¹ 26208637⁵
chicken (Gallus gallus)	Aves	QSOX2¹	quiescin Q6 sulfhydryl oxidase 2	67.59(n) 67.54(a)		417129 XM_415413.2 XP_415413.2
lizard (Anolis carolinensis)	Reptilia	QSOX2⁶	Uncharacterized protein	56(a)	1 ↔ 1	GL344237.1(39845-53936)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7691²	Xenopus laevis transcribed sequence with weak similarity more	73.84(n)		BJ073005.1
zebrafish (Danio rerio)	Actinopterygii	LOC559603¹	sulfhydryl oxidase 2-like	60.32(n) 58.44(a)		559603 XM_682961.5 XP_688053.5
fruit fly (Drosophila melanogaster)	Insecta	CG17843¹	CG17843	45.47(n) 33.74(a)		42583 NM_142741.3 NP_650998.1
worm (Caenorhabditis elegans)	Secernentea	T10H10.2⁶ F35G2.1⁶ (see all 3)	Protein F35G2.1, isoform a (see all 3)	26(a) 21(a) (see all 3)	many ↔ many many ↔ many (see all 3)	X(2294750-2298194) IV(12200978-12207930)

ENSEMBL Gene Tree for QSOX2 (if available)
TreeFam Gene Tree for QSOX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for QSOX2 gene

QSOX1²

2 SIMAP similar genes for QSOX2 using alignment to 2 protein entries: QSOX2_HUMAN (see all proteins):

QSCN6 QSOX1

QSOX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143392932^1,2	C	--	139098961(+)	`ACACCA/GCTCCC`	1	--	ut3¹		0	--	--	--	--
rs3780190^1,2	C,F,A,H	--	139099073(+)	`AAGCGA/GCAACA`	1	--	ut3¹		26		NS EA NA CSA WA	2766
rs148384572^1,2	C	--	139099127(+)	`CAACTC/TGTTAG`	1	--	ut3¹		0	--	--	--	--
rs142130253^1,2		--	139099169(+)	`AAAGCA/GGAAAA`	1	--	ut3¹		0	--	--	--	--
rs183438369^1,2		--	139099188(+)	`CAACCA/GTCAAA`	1	--	ut3¹		0	--	--	--	--
rs146198713^1,2	C	--	139099211(+)	`CTCAT-/ACAC ACACA`	1	--	ut3¹		0	--	--	--	--
rs60517775^1,2	C	--	139099245(+)	`CACAC-/ACAC GGGCA`	1	--	ut3¹		1		NA	2
rs185820544^1,2		--	139099267(+)	`CATCTA/GAGCCT`	1	--	ut3¹		0	--	--	--	--
rs146353611^1,2		--	139099300(+)	`CCTGTC/GAGACA`	1	--	ut3¹		0	--	--	--	--
rs190622150^1,2		--	139099383(+)	`GGCAAC/TGGACC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for QSOX2 (139098179 - 139137687 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/22 variations for QSOX2 (see all 22): About this table

Variant ID	Type	Subtype	PubMed ID
esv2739342	CNV	Deletion	23290073
esv2739343	CNV	Deletion	23290073
esv2739344	CNV	Deletion	23290073
esv1030583	CNV	Insertion	17803354
esv1053090	CNV	Insertion	17803354
esv993665	CNV	Insertion	20482838
nsv513002	CNV	Insertion	21212237
nsv416548	CNV	Insertion	16902084
dgv8388n71	CNV	Loss	21882294
nsv894322	CNV	Loss	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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QSOX2 for disorders           About GeneDecksing

OMIM gene information: 612860    OMIM disorders: --

3 diseases for QSOX2:    About MalaCards

neuroblastoma skin disease infertility

Genetic Association Database (GAD): QSOX2
Human Genome Epidemiology (HuGE) Navigator: QSOX2 (1 document)

Export disorders for QSOX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for QSOX2 gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with QSOX2)

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Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/quiescin 6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells. (PubMed id 14633699)^{1, 2, 9} Wittke I....Schwab M. (2003)
Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. (PubMed id 12176051)^{1, 3, 9} Thorpe C....Coppock D.L. (2002)
A genome-wide association study in 19 633 Japanese su bjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)^{1, 4} Okada Y....Kamatani N. (2010)
Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)^{1, 4} Lango Allen H....Hirschhorn J.N. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)¹ Bett J.S....Hay R.T. (2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Replication study of the association of SNPs in the LH X3-QSOX2 and IGF1 loci with adult height in the Japanese population; wide-rangin g comparison of each SNP genotype distribution. (PubMed id 22503243)¹ Fujihara J....Yasuda T. (2012)
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)¹ Stehling O....Lill R. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 169714	HGNC: 30249	AceView: QSCN6L1	Ensembl:ENSG00000165661	euGenes: HUgn169714
ECgene: QSOX2	H-InvDB: QSOX2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for QSOX2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for QSOX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for QSOX2 gene:
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GeneCards and IP:
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Quiescin Q6 Sulfhydryl Oxidase 2

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Quiescin Q6 Sulfhydryl Oxidase 2

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