Aliases for QSOX2 Gene
Aliases for QSOX2 Gene
External Ids for QSOX2 Gene
- HGNC: 30249
- Entrez Gene: 169714
- Ensembl: ENSG00000165661
- OMIM: 612860
- UniProtKB: Q6ZRP7
Previous HGNC Symbols for QSOX2 Gene
- QSCN6L1
Previous GeneCards Identifiers for QSOX2 Gene
- GC09M138239
- GC09M137879
- GC09M139098
- GC09M108562
Summaries for QSOX2 Gene
-
QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM, Jun 2009]
GeneCards Summary for QSOX2 Gene
QSOX2 (Quiescin Sulfhydryl Oxidase 2) is a Protein Coding gene. Diseases associated with QSOX2 include Neuroblastoma. GO annotations related to this gene include thiol oxidase activity. An important paralog of this gene is QSOX1.
UniProtKB/Swiss-Prot for QSOX2 Gene
-
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QSOX2 Gene
Genomics for QSOX2 Gene
Regulatory Elements for QSOX2 Gene
Enhancers for QSOX2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH09F136242 | 1.3 | FANTOM5 ENCODE | 24 | +1.4 | 1357 | 3.8 | CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF263 SP5 MXD4 | QSOX2 ANAPC2 GC09M136222 PIR36610 |
| GH09F136237 | 1.2 | Ensembl ENCODE | 22.7 | +6.6 | 6574 | 3.1 | HDAC1 CBX3 TBL1XR1 ZNF121 GATA2 CREM ZBTB2 ZBTB11 CEBPB ZEB2 | QSOX2 GC09M136222 PIR36610 |
| GH09F136227 | 1.1 | FANTOM5 Ensembl ENCODE | 16.8 | +17.5 | 17467 | 1.2 | JUND BHLHE40 FOS FOSL2 NFE2L2 | QSOX2 PMPCA SDCCAG3 NOTCH1 GC09M136222 PIR36610 |
| GH09F136249 | 0.8 | ENCODE | 19.4 | -4.8 | -4766 | 2.3 | HDAC1 ATF1 TFAP4 SAP130 CREB3L1 ARID4B ZIC2 RARA NR2F6 CREM | QSOX2 ENSG00000264527 ESP33 |
| GH09F136254 | 1 | Ensembl ENCODE | 9 | -9.2 | -9227 | 2.0 | KLF1 ESRRA SAP130 RAD21 ZFHX2 ZNF316 GLIS2 ZBTB48 PATZ1 FOS | ENSG00000264527 QSOX2 LOC101928722 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around QSOX2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the QSOX2 gene promoter:
Regulatory Element Products
Genomic Location for QSOX2 Gene
- Chromosome:
- 9
- Start:
- 136,206,333 bp from pter
- End:
- 136,245,841 bp from pter
- Size:
- 39,509 bases
- Orientation:
- Minus strand
Genomic View for QSOX2 Gene
Genes around QSOX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.3 by Ensembl
- 9q34.3 by Entrez Gene
- 9q34.3 by HGNC
QSOX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for QSOX2 Gene
Proteins for QSOX2 Gene
-
Protein details for QSOX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZRP7-QSOX2_HUMAN
- Recommended name:
- Sulfhydryl oxidase 2
- Protein Accession:
- Q6ZRP7
- A2CEE0
- A6NLB0
- Q5TB37
- Q7Z7B6
- Q86VV7
- Q8N3G2
Protein attributes for QSOX2 Gene
- Size:
- 698 amino acids
- Molecular mass:
- 77529 Da
- Cofactor:
- Name=FAD; Xref=ChEBI:CHEBI:57692;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC87262.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC85331.1; Type=Frameshift; Positions=354, 369, 616, 618; Evidence={ECO:0000305};
Protein Expression for QSOX2 Gene
Post-translational modifications for QSOX2 Gene
Other Protein References for QSOX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for QSOX2
- Invitrogen Antibodies for QSOX2
- antibodies-online Antibodies for QSOX2: See all 21
- Search GeneTex for Antibodies for QSOX2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for QSOX2
- Origene Custom Protein Services for QSOX2
- Novus Biologicals proteins for QSOX2
- Search GeneTex for Proteins for QSOX2
Assay Products
No data available for DME Specific Peptides for QSOX2 Gene
Domains & Families for QSOX2 Gene
Protein Domains for QSOX2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for QSOX2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6ZRP7UniProtKB/Swiss-Prot:
QSOX2_HUMAN :- Contains 1 ERV/ALR sulfhydryl oxidase domain.
- Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
- Domain:
-
- Contains 1 ERV/ALR sulfhydryl oxidase domain.
- Contains 1 thioredoxin domain.
- Family:
-
- Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
No data available for Gene Families for QSOX2 Gene
Function for QSOX2 Gene
Molecular function for QSOX2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 RC(R)SH + O(2) = RC(R)S-S(R)CR + H(2)O(2).
- UniProtKB/Swiss-Prot Function:
- Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
Enzyme Numbers (IUBMB) for QSOX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003756 | protein disulfide isomerase activity | IBA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016971 | flavin-linked sulfhydryl oxidase activity | IBA | -- |
| GO:0016972 | thiol oxidase activity | IEA | -- |
Phenotypes for QSOX2 Gene
- GenomeRNAi human phenotypes for QSOX2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for QSOX2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for QSOX2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for QSOX2 gene
- Search ViGene Biosciences for QSOX2
CRISPR Products
-
OriGene CRISPR knockouts for QSOX2
- GenScript: Design CRISPR guide RNA sequences for QSOX2
miRNA for QSOX2 Gene
- miRTarBase miRNAs that target QSOX2
-
- hsa-mir-125b-5p (MIRT004986)
- hsa-mir-340-5p (MIRT019576)
- hsa-mir-16-5p (MIRT031819)
- hsa-mir-92a-3p (MIRT049168)
- hsa-mir-17-3p (MIRT050770)
- hsa-mir-362-3p (MIRT393844)
- hsa-mir-329-3p (MIRT393845)
- hsa-mir-603 (MIRT393846)
- hsa-mir-8485 (MIRT393848)
- hsa-mir-7109-5p (MIRT483636)
- hsa-mir-4472 (MIRT483637)
- hsa-mir-4447 (MIRT483638)
- hsa-mir-6885-5p (MIRT483639)
- hsa-mir-328-5p (MIRT483640)
- hsa-mir-6887-5p (MIRT483641)
- hsa-mir-6795-5p (MIRT483642)
- hsa-mir-4697-5p (MIRT483643)
- hsa-mir-4488 (MIRT483644)
- hsa-mir-1237-5p (MIRT483645)
- hsa-mir-7111-5p (MIRT483646)
- hsa-mir-6870-5p (MIRT483647)
- hsa-mir-5698 (MIRT483648)
- hsa-mir-4723-5p (MIRT483649)
- hsa-mir-6825-5p (MIRT483650)
- hsa-mir-939-5p (MIRT483651)
- hsa-mir-1343-5p (MIRT483652)
- hsa-mir-1268b (MIRT483653)
- hsa-mir-1268a (MIRT483654)
- hsa-mir-6883-5p (MIRT483655)
- hsa-mir-6785-5p (MIRT483656)
- hsa-mir-4728-5p (MIRT483657)
- hsa-mir-149-3p (MIRT483658)
- hsa-mir-6090 (MIRT483659)
- hsa-mir-6853-5p (MIRT483660)
- hsa-mir-6722-3p (MIRT483661)
- hsa-mir-1909-3p (MIRT483662)
- hsa-mir-4745-5p (MIRT483663)
- hsa-mir-4481 (MIRT483664)
- hsa-mir-6798-5p (MIRT483665)
- hsa-mir-1296-3p (MIRT483666)
- hsa-mir-6805-5p (MIRT483667)
- hsa-mir-6794-5p (MIRT483668)
- hsa-mir-4716-3p (MIRT483669)
- hsa-mir-4781-5p (MIRT483670)
- hsa-mir-6510-5p (MIRT483671)
- hsa-mir-602 (MIRT614075)
- hsa-mir-6873-3p (MIRT619482)
- hsa-mir-539-3p (MIRT619483)
- hsa-mir-485-3p (MIRT619484)
- hsa-mir-3941 (MIRT619485)
- hsa-mir-6895-3p (MIRT619486)
- hsa-mir-6817-3p (MIRT619487)
- hsa-mir-7110-3p (MIRT619488)
- hsa-mir-520h (MIRT619489)
- hsa-mir-520g-3p (MIRT619490)
- hsa-mir-3973 (MIRT619491)
- hsa-mir-3184-3p (MIRT619492)
- hsa-mir-4719 (MIRT631578)
- hsa-mir-1283 (MIRT635445)
- hsa-mir-4303 (MIRT638394)
- hsa-mir-6823-3p (MIRT638395)
- hsa-mir-2114-3p (MIRT638396)
- hsa-mir-6751-3p (MIRT638397)
- hsa-mir-1199-5p (MIRT638398)
- hsa-mir-3200-5p (MIRT638399)
miRNA Products
- Search ViGene Biosciences for QSOX2
Clone Products
- VectorBuilder custom plasmid, inducible vectors for QSOX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for QSOX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for QSOX2
-
ViGene Biosciences adenoviral particle packaged cDNA for QSOX2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for QSOX2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for QSOX2 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QSOX2 Gene
Localization for QSOX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for QSOX2 Gene
- Membrane; Single-pass membrane protein. Secreted. Cell membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 5 |
| plasma membrane | 4 |
| extracellular | 4 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IBA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for QSOX2 Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | IBA | -- |
| GO:0045454 | cell redox homeostasis | IEA | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for QSOX2 Gene
Transcripts for QSOX2 Gene
mRNA/cDNA for QSOX2 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (91) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for QSOX2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for QSOX2
- GenScript: Design CRISPR guide RNA sequences for QSOX2
miRNA Products
- Search ViGene Biosciences for QSOX2
Clone Products
- VectorBuilder custom plasmid, inducible vectors for QSOX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for QSOX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - |
Expression for QSOX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Blood (Hematopoietic System)
This gene is overexpressed in Breast (26.7), Adipocyte (17.2), Bone (7.9), and Serum (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for QSOX2 Gene
NURSA nuclear receptor signaling pathways regulating expression of QSOX2 Gene:
QSOX2SOURCE GeneReport for Unigene cluster for QSOX2 Gene:
Hs.144073mRNA Expression by UniProt/SwissProt for QSOX2 Gene:
Q6ZRP7-QSOX2_HUMAN
Tissue specificity:
Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles.
Primer Products
-
OriGene qPCR primer pairs for QSOX2
-
OriGene qPCR primer pairs and template standards for QSOX2
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for QSOX2 Gene
Orthologs for QSOX2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | QSOX2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Qsox2 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | QSOX2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Qsox2 34 |
|
||
| cow (Bos Taurus) |
Mammalia | QSOX2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | QSOX2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | QSOX2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | QSOX2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | QSOX2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | qsox2 34 |
|
||
| Str.11376 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7691 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC559603 34 |
|
||
| QSOX2 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG17843 34 35 |
|
||
| CG4670 35 |
|
ManyToMany | |||
| CG31413 35 |
|
ManyToMany | |||
| CG6690 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | T10H10.2 35 |
|
ManyToMany | |
| F47B7.2 35 |
|
ManyToMany | |||
| F35G2.1 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for QSOX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for QSOX2 Gene
(2) SIMAP similar genes for QSOX2 Gene using alignment to 2 proteins:
Variants for QSOX2 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10114171 | -- | 136,222,462(+) | AACCC(C/T)GCGTG | intron-variant | |
| rs10114651 | -- | 136,234,095(+) | tcacg(A/T)ggctc | intron-variant | |
| rs10115360 | -- | 136,221,299(+) | CAAAG(C/G)GCTTG | intron-variant | |
| rs10115394 | -- | 136,234,811(+) | GGAGC(A/G)AGGCT | intron-variant | |
| rs10116187 | -- | 136,222,317(+) | GCTTC(A/G)TGGCC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv951202 | CNV | deletion | 24416366 |
| nsv825173 | CNV | gain | 20364138 |
| nsv513002 | CNV | insertion | 21212237 |
| nsv481200 | CNV | novel sequence insertion | 20440878 |
| nsv480676 | CNV | novel sequence insertion | 20440878 |
| nsv480660 | CNV | novel sequence insertion | 20440878 |
| nsv480222 | CNV | novel sequence insertion | 20440878 |
| nsv479481 | CNV | novel sequence insertion | 20440878 |
| nsv479445 | CNV | novel sequence insertion | 20440878 |
| nsv479190 | CNV | novel sequence insertion | 20440878 |
| nsv479172 | CNV | novel sequence insertion | 20440878 |
| nsv479171 | CNV | novel sequence insertion | 20440878 |
| nsv475572 | CNV | novel sequence insertion | 20440878 |
| nsv474964 | CNV | novel sequence insertion | 20440878 |
| nsv474839 | CNV | novel sequence insertion | 20440878 |
| nsv474715 | CNV | novel sequence insertion | 20440878 |
| nsv474106 | CNV | novel sequence insertion | 20440878 |
| nsv473978 | CNV | novel sequence insertion | 20440878 |
| nsv473948 | CNV | novel sequence insertion | 20440878 |
| nsv473737 | CNV | novel sequence insertion | 20440878 |
| nsv416548 | CNV | insertion | 16902084 |
| nsv1133750 | CNV | deletion | 24896259 |
| nsv1075284 | CNV | deletion | 25765185 |
| nsv1046074 | CNV | gain | 25217958 |
| nsv1040564 | CNV | gain | 25217958 |
| esv993665 | CNV | insertion | 20482838 |
| esv3622004 | CNV | loss | 21293372 |
| esv3622003 | CNV | gain | 21293372 |
| esv3622002 | CNV | loss | 21293372 |
| esv2739344 | CNV | deletion | 23290073 |
| esv2739343 | CNV | deletion | 23290073 |
| esv2739342 | CNV | deletion | 23290073 |
| esv1053090 | CNV | insertion | 17803354 |
| esv1030583 | CNV | insertion | 17803354 |
| dgv13001n54 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.22;
62.17% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for QSOX2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- QSOX2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QSOX2 Gene
Disorders for QSOX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neuroblastoma |
|
|
Search QSOX2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for QSOX2
No data available for UniProtKB/Swiss-Prot and Genatlas for QSOX2 Gene
Publications for QSOX2 Gene
- Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/quiescin 6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells. (PMID: 14633699) Wittke I. … Schwab M. (Cancer Res. 2003) 3 4 22 64
- Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. (PMID: 12176051) Thorpe C. … Coppock D.L. (Arch. Biochem. Biophys. 2002) 2 3 22 64
- A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y. … Kamatani N. (Hum. Mol. Genet. 2010) 3 46 64
- Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for QSOX2 Gene
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- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for QSOX2
- Origene Custom Protein Services for QSOX2
- Origene mouse_rna, siRNA, rat_shrna, shRNA, and RNAi products in human, mouse, rat for QSOX2
- Browse OriGene Inhibitory RNA Products For QSOX2
- OriGene qPCR primer pairs for QSOX2
- OriGene qPCR primer pairs and template standards for QSOX2
- OriGene CRISPR knockouts for QSOX2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For QSOX2
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for QSOX2
- GenScript Custom Assay Services for QSOX2
- GenScript Custom overexpressing Cell Line Services for QSOX2
- GenScript: Design CRISPR guide RNA sequences for QSOX2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for QSOX2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for QSOX2
- Novus Biologicals proteins for QSOX2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for QSOX2
- ViGene Biosciences adenoviral particle packaged cDNA for QSOX2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for QSOX2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for QSOX2 gene
- Search ViGene Biosciences for QSOX2
- Horizon Cell Lines for QSOX2
- Cyagen custom Knockout/knockin (KOKI) mouse models for QSOX2
- VectorBuilder custom plasmid, inducible vectors for QSOX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for QSOX2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for QSOX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab