Aliases for QSOX2 Gene
Aliases for QSOX2 Gene
External Ids for QSOX2 Gene
- HGNC: 30249
- Entrez Gene: 169714
- Ensembl: ENSG00000165661
- OMIM: 612860
- UniProtKB: Q6ZRP7
Previous HGNC Symbols for QSOX2 Gene
- QSCN6L1
Previous GeneCards Identifiers for QSOX2 Gene
- GC09M138239
- GC09M137879
- GC09M139098
- GC09M108562
Summaries for QSOX2 Gene
-
QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM, Jun 2009]
GeneCards Summary for QSOX2 Gene
QSOX2 (Quiescin Sulfhydryl Oxidase 2) is a Protein Coding gene. Diseases associated with QSOX2 include Neuroblastoma and Deafness, Autosomal Recessive 79. GO annotations related to this gene include thiol oxidase activity. An important paralog of this gene is QSOX1.
UniProtKB/Swiss-Prot for QSOX2 Gene
-
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QSOX2 Gene
Genomics for QSOX2 Gene
Regulatory Elements for QSOX2 Gene
Enhancers for QSOX2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH09G136242 | 1.6 | FANTOM5 ENCODE dbSUPER | 24 | +1.4 | 1357 | 3.8 | FOXA2 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF766 GLIS2 | QSOX2 GC09M136222 PIR36610 |
| GH09G136227 | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 16.8 | +17.5 | 17467 | 1.2 | L3MBTL2 BHLHE40 ATF2 FOSL1 JUND CREB1 FOS FOSL2 NFE2L2 | QSOX2 SDCCAG3 PMPCA NOTCH1 PIR36610 GC09M136222 |
| GH09G136237 | 1.2 | ENCODE dbSUPER | 18.4 | +7.5 | 7534 | 1.1 | HDAC1 CBX3 PTBP1 TBL1XR1 TCF12 ZNF766 GATA2 CREM ZBTB2 ZBTB11 | QSOX2 GC09M136222 PIR36610 |
| GH09G136249 | 1 | ENCODE dbSUPER | 19.4 | -4.8 | -4766 | 2.3 | HDAC1 TFAP4 ATF1 SAP130 CREB3L1 ARID4B ZIC2 RARA NR2F6 CREM | QSOX2 ESP33 GC09M136250 |
| GH09G135977 | 1.1 | Ensembl ENCODE dbSUPER | 10.7 | +266.9 | 266902 | 2.6 | KLF1 GLIS1 KLF9 MAX ZNF600 ZNF394 ZBTB8A MYC | QSOX2 UBAC1 PIR44599 GC09P136007 GC09P136008 GC09P136009 GC09P136010 GC09P136011 GC09P136012 GC09P136014 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around QSOX2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the QSOX2 gene promoter:
Regulatory Element Products
Genomic Location for QSOX2 Gene
- Chromosome:
- 9
- Start:
- 136,206,333 bp from pter
- End:
- 136,245,841 bp from pter
- Size:
- 39,509 bases
- Orientation:
- Minus strand
Genomic View for QSOX2 Gene
Genes around QSOX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.3 by Ensembl
- 9q34.3 by Entrez Gene
- 9q34.3 by HGNC
QSOX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for QSOX2 Gene
Proteins for QSOX2 Gene
-
Protein details for QSOX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZRP7-QSOX2_HUMAN
- Recommended name:
- Sulfhydryl oxidase 2
- Protein Accession:
- Q6ZRP7
- A2CEE0
- A6NLB0
- Q5TB37
- Q7Z7B6
- Q86VV7
- Q8N3G2
Protein attributes for QSOX2 Gene
- Size:
- 698 amino acids
- Molecular mass:
- 77529 Da
- Cofactor:
- Name=FAD; Xref=ChEBI:CHEBI:57692;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC87262.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC85331.1; Type=Frameshift; Positions=354, 369, 616, 618; Evidence={ECO:0000305};
Protein Expression for QSOX2 Gene
Post-translational modifications for QSOX2 Gene
Other Protein References for QSOX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for QSOX2
- Invitrogen Antibodies for QSOX2
- antibodies-online Antibodies for QSOX2: See all 21
- Search GeneTex for Antibodies for QSOX2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for QSOX2
- Origene Custom Protein Services for QSOX2
- Novus Biologicals proteins for QSOX2
- Search GeneTex for Proteins for QSOX2
No data available for DME Specific Peptides for QSOX2 Gene
Domains & Families for QSOX2 Gene
Protein Domains for QSOX2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for QSOX2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6ZRP7- Family:
-
- Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
No data available for Gene Families for QSOX2 Gene
Function for QSOX2 Gene
Molecular function for QSOX2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 RC(R)SH + O(2) = RC(R)S-S(R)CR + H(2)O(2).
- UniProtKB/Swiss-Prot Function:
- Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
Enzyme Numbers (IUBMB) for QSOX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003756 | protein disulfide isomerase activity | IBA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016971 | flavin-linked sulfhydryl oxidase activity | IBA | -- |
| GO:0016972 | thiol oxidase activity | IEA | -- |
Phenotypes for QSOX2 Gene
- GenomeRNAi human phenotypes for QSOX2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for QSOX2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for QSOX2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for QSOX2 gene
- Search ViGene Biosciences for QSOX2
CRISPR Products
-
OriGene CRISPR knockouts for QSOX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for QSOX2
- GenScript: Design CRISPR guide RNA sequences for QSOX2
miRNA for QSOX2 Gene
- miRTarBase miRNAs that target QSOX2
-
- hsa-mir-125b-5p (MIRT004986)
- hsa-mir-340-5p (MIRT019576)
- hsa-mir-16-5p (MIRT031819)
- hsa-mir-92a-3p (MIRT049168)
- hsa-mir-17-3p (MIRT050770)
- hsa-mir-362-3p (MIRT393844)
- hsa-mir-329-3p (MIRT393845)
- hsa-mir-603 (MIRT393846)
- hsa-mir-8485 (MIRT393848)
- hsa-mir-7109-5p (MIRT483636)
- hsa-mir-4472 (MIRT483637)
- hsa-mir-4447 (MIRT483638)
- hsa-mir-6885-5p (MIRT483639)
- hsa-mir-328-5p (MIRT483640)
- hsa-mir-6887-5p (MIRT483641)
- hsa-mir-6795-5p (MIRT483642)
- hsa-mir-4697-5p (MIRT483643)
- hsa-mir-4488 (MIRT483644)
- hsa-mir-1237-5p (MIRT483645)
- hsa-mir-7111-5p (MIRT483646)
- hsa-mir-6870-5p (MIRT483647)
- hsa-mir-5698 (MIRT483648)
- hsa-mir-4723-5p (MIRT483649)
- hsa-mir-6825-5p (MIRT483650)
- hsa-mir-939-5p (MIRT483651)
- hsa-mir-1343-5p (MIRT483652)
- hsa-mir-1268b (MIRT483653)
- hsa-mir-1268a (MIRT483654)
- hsa-mir-6883-5p (MIRT483655)
- hsa-mir-6785-5p (MIRT483656)
- hsa-mir-4728-5p (MIRT483657)
- hsa-mir-149-3p (MIRT483658)
- hsa-mir-6090 (MIRT483659)
- hsa-mir-6853-5p (MIRT483660)
- hsa-mir-6722-3p (MIRT483661)
- hsa-mir-1909-3p (MIRT483662)
- hsa-mir-4745-5p (MIRT483663)
- hsa-mir-4481 (MIRT483664)
- hsa-mir-6798-5p (MIRT483665)
- hsa-mir-1296-3p (MIRT483666)
- hsa-mir-6805-5p (MIRT483667)
- hsa-mir-6794-5p (MIRT483668)
- hsa-mir-4716-3p (MIRT483669)
- hsa-mir-4781-5p (MIRT483670)
- hsa-mir-6510-5p (MIRT483671)
- hsa-mir-602 (MIRT614075)
- hsa-mir-6873-3p (MIRT619482)
- hsa-mir-539-3p (MIRT619483)
- hsa-mir-485-3p (MIRT619484)
- hsa-mir-3941 (MIRT619485)
- hsa-mir-6895-3p (MIRT619486)
- hsa-mir-6817-3p (MIRT619487)
- hsa-mir-7110-3p (MIRT619488)
- hsa-mir-520h (MIRT619489)
- hsa-mir-520g-3p (MIRT619490)
- hsa-mir-3973 (MIRT619491)
- hsa-mir-3184-3p (MIRT619492)
- hsa-mir-4719 (MIRT631578)
- hsa-mir-1283 (MIRT635445)
- hsa-mir-4303 (MIRT638394)
- hsa-mir-6823-3p (MIRT638395)
- hsa-mir-2114-3p (MIRT638396)
- hsa-mir-6751-3p (MIRT638397)
- hsa-mir-1199-5p (MIRT638398)
- hsa-mir-3200-5p (MIRT638399)
miRNA Products
- Search ViGene Biosciences for QSOX2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for QSOX2
- Browse OriGene Inhibitory RNA Products For QSOX2
-
ViGene Biosciences ready-to-package AAV shRNAs for QSOX2 gene
Clone Products
-
OriGene ORF clones in human for QSOX2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for QSOX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for QSOX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for QSOX2
-
ViGene Biosciences adenoviral particle packaged cDNA for QSOX2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for QSOX2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for QSOX2 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QSOX2 Gene
Localization for QSOX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for QSOX2 Gene
- Membrane; Single-pass membrane protein. Secreted. Cell membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 5 |
| plasma membrane | 4 |
| extracellular | 4 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IBA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
Pathways & Interactions for QSOX2 Gene
No Data Available
Interacting Proteins for QSOX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045454 | cell redox homeostasis | IEA | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for QSOX2 Gene
Transcripts for QSOX2 Gene
mRNA/cDNA for QSOX2 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (91) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for QSOX2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for QSOX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for QSOX2
- GenScript: Design CRISPR guide RNA sequences for QSOX2
miRNA Products
- Search ViGene Biosciences for QSOX2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for QSOX2
- Browse OriGene Inhibitory RNA Products For QSOX2
-
ViGene Biosciences ready-to-package AAV shRNAs for QSOX2 gene
Clone Products
-
OriGene ORF clones in human for QSOX2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for QSOX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for QSOX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - |
Expression for QSOX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Blood (Hematopoietic System)
This gene is overexpressed in Breast (26.7), Adipocyte (17.2), Bone (7.9), and Serum (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for QSOX2 Gene
NURSA nuclear receptor signaling pathways regulating expression of QSOX2 Gene:
QSOX2SOURCE GeneReport for Unigene cluster for QSOX2 Gene:
Hs.144073mRNA Expression by UniProt/SwissProt for QSOX2 Gene:
Q6ZRP7-QSOX2_HUMAN
Tissue specificity:
Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles.
Evidence on tissue expression from TISSUES for QSOX2 Gene
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for QSOX2
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for QSOX2 Gene
Orthologs for QSOX2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | QSOX2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Qsox2 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | QSOX2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Qsox2 34 |
|
||
| cow (Bos Taurus) |
Mammalia | QSOX2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | QSOX2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | QSOX2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | QSOX2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | QSOX2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | qsox2 34 |
|
||
| Str.11376 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7691 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC559603 34 |
|
||
| QSOX2 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG17843 34 35 |
|
||
| CG4670 35 |
|
ManyToMany | |||
| CG31413 35 |
|
ManyToMany | |||
| CG6690 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | T10H10.2 35 |
|
ManyToMany | |
| F47B7.2 35 |
|
ManyToMany | |||
| F35G2.1 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for QSOX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for QSOX2 Gene
(2) SIMAP similar genes for QSOX2 Gene using alignment to 2 proteins:
Variants for QSOX2 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000105364 | -- | 136,230,584(+) | ACGTC(A/G)GGCCA | intron-variant | |
| rs1000139386 | -- | 136,221,507(+) | CCCTC(A/G)TGCAT | intron-variant | |
| rs1000281055 | -- | 136,234,939(+) | TTTAC(C/T)GGGCT | intron-variant | |
| rs1000314340 | -- | 136,215,775(+) | GCTGA(C/G)AGCCC | intron-variant | |
| rs1000345269 | -- | 136,215,455(+) | TGTGC(C/T)TCCTA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv13001n54 | CNV | gain | 21841781 |
| esv1030583 | CNV | insertion | 17803354 |
| esv1053090 | CNV | insertion | 17803354 |
| esv2739342 | CNV | deletion | 23290073 |
| esv2739343 | CNV | deletion | 23290073 |
| esv2739344 | CNV | deletion | 23290073 |
| esv3622002 | CNV | loss | 21293372 |
| esv3622003 | CNV | gain | 21293372 |
| esv3622004 | CNV | loss | 21293372 |
| esv993665 | CNV | insertion | 20482838 |
| nsv1040564 | CNV | gain | 25217958 |
| nsv1046074 | CNV | gain | 25217958 |
| nsv1075284 | CNV | deletion | 25765185 |
| nsv1133750 | CNV | deletion | 24896259 |
| nsv416548 | CNV | insertion | 16902084 |
| nsv473737 | CNV | novel sequence insertion | 20440878 |
| nsv473948 | CNV | novel sequence insertion | 20440878 |
| nsv473978 | CNV | novel sequence insertion | 20440878 |
| nsv474106 | CNV | novel sequence insertion | 20440878 |
| nsv474715 | CNV | novel sequence insertion | 20440878 |
| nsv474839 | CNV | novel sequence insertion | 20440878 |
| nsv474964 | CNV | novel sequence insertion | 20440878 |
| nsv475572 | CNV | novel sequence insertion | 20440878 |
| nsv479171 | CNV | novel sequence insertion | 20440878 |
| nsv479172 | CNV | novel sequence insertion | 20440878 |
| nsv479190 | CNV | novel sequence insertion | 20440878 |
| nsv479445 | CNV | novel sequence insertion | 20440878 |
| nsv479481 | CNV | novel sequence insertion | 20440878 |
| nsv480222 | CNV | novel sequence insertion | 20440878 |
| nsv480660 | CNV | novel sequence insertion | 20440878 |
| nsv480676 | CNV | novel sequence insertion | 20440878 |
| nsv481200 | CNV | novel sequence insertion | 20440878 |
| nsv513002 | CNV | insertion | 21212237 |
| nsv825173 | CNV | gain | 20364138 |
| nsv951202 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.22;
62.17% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for QSOX2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- QSOX2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QSOX2 Gene
Disorders for QSOX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neuroblastoma |
|
|
| deafness, autosomal recessive 79 |
|
|
| deafness, autosomal recessive 33 |
|
|
Search QSOX2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for QSOX2
No data available for UniProtKB/Swiss-Prot and Genatlas for QSOX2 Gene
Publications for QSOX2 Gene
- Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/quiescin 6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells. (PMID: 14633699) Wittke I. … Schwab M. (Cancer Res. 2003) 3 4 22 64
- Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. (PMID: 12176051) Thorpe C. … Coppock D.L. (Arch. Biochem. Biophys. 2002) 2 3 22 64
- Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64
- A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y. … Kamatani N. (Hum. Mol. Genet. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for QSOX2 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for QSOX2
- Origene Custom Protein Services for QSOX2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for QSOX2
- Browse OriGene Inhibitory RNA Products For QSOX2
- OriGene qPCR primer pairs for QSOX2
- OriGene CRISPR knockouts for QSOX2
- OriGene ORF clones in human for QSOX2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For QSOX2
- GenScript: Next-day shipping cDNA ORF clone for QSOX2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for QSOX2
- GenScript Custom Assay Services for QSOX2
- GenScript Custom overexpressing Cell Line Services for QSOX2
- GenScript: Design CRISPR guide RNA sequences for QSOX2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for QSOX2
- Browse Sino Biological cDNA Clones
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- Novus Biologicals Antibodies for QSOX2
- Novus Biologicals proteins for QSOX2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for QSOX2
- Search GeneTex for Antibodies for QSOX2
- Search GeneTex for Proteins for QSOX2
- ViGene Biosciences adenoviral particle packaged cDNA for QSOX2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for QSOX2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for QSOX2 gene
- Search ViGene Biosciences for QSOX2
- Horizon Cell Lines for QSOX2
- Cyagen custom Knockout/knockin (KOKI) mouse models for QSOX2
- VectorBuilder custom plasmid, inducible vectors for QSOX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for QSOX2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for QSOX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (14) ProtoNet
- (15) Blocks
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- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (133) NCBI Bookshelf
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer