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QSOX2 Gene

protein-coding   GIFtS: 44

GC09M138239
quiescin Q6 sulfhydryl oxidase 2
(Previous name: quiescin Q6-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: QSCN6L1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp762A2013 1, 2
EC 1.8.3.2 3
OTTHUMP00000022565 2
QSCN6L1 2, 3
SOXN 1, 2, 3
Descriptions
Neuroblastoma-derived sulfhydryl oxidase 2, 3
Quiescin Q6-like protein 1 3
quiescin Q6 sulfhydryl oxidase 2 2
quiescin Q6-like 1 1, 2
External Ids
HGNC: 302491
Entrez Gene: 1697142
UniProtKB: Q6ZRP73
Ensembl: ENSG000001656617
Search outside databases for aliases for QSOX2 gene

Previous GC identifer: GC09M137879

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides
with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a
variety of secreted proteins. Also seems to play a role in regulating the sensitization of
neuroblastoma cells for interferon-gamma-induced apoptosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

QSOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M138239:     (about GC identifiers)

Start:
138,238,000 bp from pter
End:
138,277,508 bp from pter
Size:
39,509 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000009.10  NT_019501.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7 (See protein sequence)
Recommended Name: Sulfhydryl oxidase 2 precursor  
Size: 698 amino acids; 77529 Da
Cofactor: Binds 1 FAD per subunit (Potential)
Subcellular location: Membrane; Single-pass membrane protein. Secreted. Cell membrane; Single-pass
membrane protein (Potential). Nucleus membrane; Single-pass membrane protein (Potential).
Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane
Sequence caution: Sequence=CAC85331.1; Type=Frameshift; Positions=354, 369, 616, 618;
Secondary accessions: A2CEE0 A6NLB0 Q5TB37 Q7Z7B6 Q86VV7 Q8N3G2

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_859052.3  

    ENSEMBL proteins: 
    ENSP00000351536 ENSP00000374122 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005634 nucleus IEA--
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    GO:0031965 nuclear membrane IEA--
    About this table

    Antibodies for QSOX2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for QSOX2
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for QSOX2

    Assays for QSOX2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR017905 ERV/ALR_sulphydryl_oxidase
     IPR006863 Evr1_Alr
     IPR013766 Thioredoxin_domain
     IPR017936 Thioredoxin-like


       GeneDecks  QSOX2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6ZRP7

    ProtoNet protein and cluster: Q6ZRP7

    2 Blocks protein families:
    IPB006662 Thioredoxin type domain
    IPB006863 Erv1/Alr


    UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
    Similarity: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family
    Similarity: Contains 1 ERV/ALR sulfhydryl oxidase domain
    Similarity: Contains 1 thioredoxin domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (QSOX2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (QSCN6L1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181701

                  Applied Biosystems Silencer® siRNAs for QSOX2

                  Sigma-Aldrich siRNA and siRNA Panels for QSOX2  
                         Sigma-Aldrich shRNA for QSOX2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_181701
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_181701
                                     untagged cDNA clone in CMV expression vector: NM_181701 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_181701

    UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
    Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides
    with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a
    variety of secreted proteins. Also seems to play a role in regulating the sensitization of
    neuroblastoma cells for interferon-gamma-induced apoptosis
    Catalytic activity: 4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O
    Enzyme Number (IUBMB): EC 1.8.3.2 

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491 oxidoreductase activity IEA--
    GO:0016972 thiol oxidase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454 cell redox homeostasis IEA--
    GO:0055114 oxidation reduction IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for QSOX2
    2 Novoseek chemical compound relationships for QSOX2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    dithiothreitol 54.26 2 15568811 (1), 19409596 (1)
    flavin 46.45 1 15683237 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (QSOX2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (QSCN6L1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181701

                  Sigma-Aldrich siRNA and siRNA Panels for QSOX2  
                         Sigma-Aldrich shRNA for QSOX2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_181701  

    REFSEQ mRNAs for QSOX2 gene: 

    NM_181701.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_181701  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_181701
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_181701
                                     untagged cDNA clone in CMV expression vector: NM_181701 

    Additional cDNA sequence: 

    AJ318051.1 AJ420461.1 AK128077.1 AK128750.1 AL834369.1 BC047604.2 CR601649.1 

    6 DOTS entries:

    DT.110458  DT.97836908  DT.97775695  DT.75100956  DT.40213602  DT.121194112 

    24/91 AceView cDNA sequences (see all 91 ):

    AA514465 AI742021 AA493143 BI492379 AI304528 BE875636 BQ187181 AI753180 
    CR601649 BE349598 AI028313 AI280985 H08428 AI309245 BM352357 BU175119 
    BG180984 BG745598 AW515514 AW873348 BQ227274 BQ185744 BQ953575 AI056976 

    Unigene Cluster for QSOX2:

    Quiescin Q6 sulfhydryl oxidase 2
    Hs.657864  [show with all ESTs]
    Unigene Representative Sequence: AJ318051


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for QSOX2

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                            -     -                             -           -               
    SP2:                                                  -                             -           -               
    SP3:                                                                                -           -               
    SP4:                                                                                                            
    SP5:                    -     -                 -     -                                                         

    About this scheme

    ECgene alternative splicing isoforms for QSOX2

    2 Ensembl transcripts including schematic representations:
    ENST00000358701  ENST00000389471  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    QSOX2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for QSOX2

    1 / 2

    6 probe-sets matching QSOX2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    61673_at2 U95-C 1 1.00 1.00 0.94 1.26 -- -- -- -- --

    75405_at2 U95-E 1 1.00 1.00 0.58 0.75 -- -- -- -- --

    235239_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    227146_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    235239_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    227146_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  QSOX2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAAATGTCAG

    SOURCE GeneReport for Unigene cluster: Hs.657864

    UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
    Tissue specificity: Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly
    expressed in lung, liver and skeletal muscles

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for QSOX2 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    QSOX21   -- quiescin Q6 sulfhydryl oxidase 2 80.17(n)
    77.87(a)
    607571  XM_844307.1  XP_849400.1 
    chimpanzee
    (Pan troglodytes)
    QSOX21   -- quiescin Q6 sulfhydryl oxidase 2 98.09(n)
    97.85(a)
    464853  XM_520361.2  XP_520361.2 
    rat
    (Rattus norvegicus)
    Qsox21   -- quiescin Q6 sulfhydryl oxidase 2 80.29(n)
    79.28(a)
    681023  XM_001059980.1  XP_001059980.1 
    mouse
    (Mus musculus)
    Qsox21, 5 25
    quiescin Q6 sulfhydryl oxidase 21, 5 81.69(n)1
    82.57(a)1
    2276381  NM_153559.21  NP_705787.11 
     AK0420365  AK1403245  (see all 12)
    chicken
    (Gallus gallus)
    QSOX21   -- quiescin Q6 sulfhydryl oxidase 2 67.59(n)
    67.54(a)
    417129  XM_415413.2  XP_415413.2 
    About this table        Species with no ortholog for QSOX2

    ENSEMBL Gene Tree for QSOX2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for QSOX2 gene
    QSOX12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/254 NCBI SNPs in QSOX2 are shown (see all 254 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 85)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs70245791,2
    A,C,F,H138240234(+) AAGAGC/TGTTTG 1 -- ut314Minor allele frequency- T:0.13EU EA WA 416
    rs37801901,2
    A,C,F,H138238894(+) AAGCGG/ACAACA 1 -- ut318Minor allele frequency- A:0.50EU EA WA 836
    rs123808521,2
    C,F138258494(+) GTTCTT/CCTCTT 1 E/K mis1 ese3 trp35Minor allele frequency- C:0.14NA EU EA WA 490
    rs38111261,2
    F,H138239748(-) TGTTCG/CACACC 1 -- ut315Minor allele frequency- C:0.02EA EU WA 1918
    rs38111271,2
    F,H138239421(-) AAAGCC/GCCCCC 1 -- ut314Minor allele frequency- G:0.01EU EA WA 418
    rs101173331,2
    C138239272(+) ATGACA/CAAAGC 1 -- ut310--------
    rs126846501,2
    C,F,H138250475(+) TTCGAC/TCTAGG 1 K/K syn110Minor allele frequency- N:0.00EA NA EU WA 818
    --
    rs96961161,2
    C138240626(+) CTCTCC/TGGAAG 1 P/P syn1 ese30--------
    rs78495851,2
    A,C,F,H138251691(+) CTTTTG/TTATTT 1 -- int14Minor allele frequency- T:0.50EU EA WA 418
    rs78618291,2
    A,C,F,H138259864(+) TCTCTC/GCTTAG 1 -- int1 trp312Minor allele frequency- G:0.31EU EA WA 1258
    About this table

    HapMap Linkage Disequilibrium images for QSOX2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/34 PubMed articles for QSOX2 gene (see all 34 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 169714 HGNC: 30249 AceView: QSCN6L1 Ensembl:ENSG00000165661 euGenes: HUgn169714
    ECgene: QSOX2 H-InvDB: QSOX2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for QSOX2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for QSOX2 Antibodies for QSOX2
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