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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

QSOX2 Gene

protein-coding   GIFtS: 53
GCID: GC09M139098

Quiescin Q6 Sulfhydryl Oxidase 2

(Previous name: quiescin Q6-like 1)
(Previous symbol: QSCN6L1)
Microbiology & Infectious Diseases Congress
  See related diseases
at
MalaCards
 

Aliases
for QSOX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Quiescin Q6 Sulfhydryl Oxidase 21 2     Neuroblastoma-Derived Sulfhydryl Oxidase2 3
QSCN6L11 2 3     Quiescin Q6-Like Protein 12 3
SOXN2 3 5     Sulfhydryl Oxidase 22
Quiescin Q6-Like 11 2     EC 1.8.3.23

External Ids:    HGNC: 302491   Entrez Gene: 1697142   Ensembl: ENSG000001656617   OMIM: 6128605   UniProtKB: Q6ZRP73   

Export aliases for QSOX2 gene to outside databases

Previous GC identifers: GC09M138239 GC09M137879 GC09M108562


Summaries
for QSOX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for QSOX2 Gene:
QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the
sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003
(PubMed 14633699)).(supplied by OMIM, Jun 2009)

GeneCards Summary for QSOX2 Gene: 
QSOX2 (quiescin Q6 sulfhydryl oxidase 2) is a protein-coding gene. Diseases associated with QSOX2 include neuroblastoma, and skin disease. GO annotations related to this gene include thiol oxidase activity. An important paralog of this gene is QSOX1.

UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the
reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted
proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for
interferon-gamma-induced apoptosis




Genomic Views
for QSOX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_019501.13  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the QSOX2 gene promoter:
         SRF   USF1   NF-1   Sp1   p53   SRF (504 AA)   AP-4   CUTL1   HNF-4alpha1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: QSOX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for QSOX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QSOX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

QSOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QSOX2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139098:  view genomic region     (about GC identifiers)

Start:
 139,098,179 bp from pter      End:
 139,137,687 bp from pter
Size:
 39,509 bases      Orientation:
 minus strand

1 alternative location:
Chr9-,NW_003315926 433-798     

Proteins
for QSOX2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7 (See protein sequence)
Recommended Name: Sulfhydryl oxidase 2 precursor  
Size: 698 amino acids; 77529 Da
Cofactor: Binds 1 FAD per subunit (Potential)
Subcellular location: Membrane; Single-pass membrane protein. Secreted. Cell membrane; Single-pass membrane
protein (Potential). Nucleus membrane; Single-pass membrane protein (Potential). Note=Seems to be predominantly
targeted to the nuclear and outer plasma membrane
Sequence caution: Sequence=BAC87262.1; Type=Erroneous initiation; Sequence=CAC85331.1; Type=Frameshift;
Positions=354, 369, 616, 618;
Secondary accessions: A2CEE0 A6NLB0 Q5TB37 Q7Z7B6 Q86VV7 Q8N3G2

Explore the universe of human proteins at neXtProt for QSOX2: NX_Q6ZRP7

Explore proteomics data for QSOX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZRP7

    • QSOX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    QSOX2 Protein Expression
    REFSEQ proteins: NP_859052.3  
    ENSEMBL proteins: 
     ENSP00000351536   ENSP00000389089  

    Human Recombinant Protein Products for QSOX2: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for QSOX2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0031965nuclear membrane IEA--

    QSOX2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for QSOX2 
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    Protein Domains /
    Families
    for QSOX2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 4 InterPro protein domains:
     IPR017905 ERV/ALR_sulphydryl_oxidase
     IPR012336 Thioredoxin-like_fold
     IPR006863 Evr1_Alr
     IPR013766 Thioredoxin_domain

    Graphical View of Domain Structure for InterPro Entry Q6ZRP7

    ProtoNet protein and cluster: Q6ZRP7

    2 Blocks protein domains:
    IPB006662 Thioredoxin type domain
    IPB006863 Erv1/Alr


    UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
    Similarity: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family
    Similarity: Contains 1 ERV/ALR sulfhydryl oxidase domain
    Similarity: Contains 1 thioredoxin domain


    QSOX2 for domains           About GeneDecksing


    Function
    for QSOX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QSOX2_HUMAN, Q6ZRP7
    Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the
    reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted
    proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for
    interferon-gamma-induced apoptosis
    Catalytic activity: 2 R'C(R)SH + O(2) = R'C(R)S-S(R)CR' + H(2)O(2)

         Enzyme Number (IUBMB): EC 1.8.3.21

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016972thiol oxidase activity IEA--
         
    QSOX2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for QSOX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for QSOX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for QSOX2 
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    miRNA
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    hsa-mir-125b (MIRT004986)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat QSOX2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate QSOX2 (see all 18):
    hsa-miR-320a hsa-miR-607 hsa-miR-125a-5p hsa-miR-605 hsa-miR-500a hsa-miR-105 hsa-miR-125b hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmid: QSOX2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for QSOX2
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                         Customized lentivirus expression plasmids for stable overexpression of QSOX2 

    Cell Line
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    Search LifeMap BioReagents cell lines for QSOX2
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QSOX2


    Pathways & Interactions
    for QSOX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QSOX2

    3 Interacting proteins for QSOX2 (Q6ZRP73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG2AQ2TAZ03I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    CLN3Q132863I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045454cell redox homeostasis IEA--
    GO:0055114oxidation-reduction process ----

    QSOX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for QSOX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    QSOX2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for QSOX2

    3 HMDB Compounds for QSOX2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 Novoseek inferred chemical compound relationships for QSOX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavin 66.1 2 19397338 (1), 15683237 (1)
    dithiothreitol 65.3 2 15568811 (1), 19409596 (1)
    h2o2 46.9 1 12202243 (1)

    Search CenterWatch for drugs/clinical trials and news about QSOX2

    Transcripts
    for QSOX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for QSOX2 gene: 
    NM_181701.3  

    Unigene Cluster for QSOX2:

    Quiescin Q6 sulfhydryl oxidase 2
    Hs.144073  [show with all ESTs]
    Unigene Representative Sequence: AJ318051
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358701(uc010nbi.2) ENST00000455222
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat QSOX2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate QSOX2 (see all 18):
    hsa-miR-320a hsa-miR-607 hsa-miR-125a-5p hsa-miR-605 hsa-miR-500a hsa-miR-105 hsa-miR-125b hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmid: QSOX2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for QSOX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QSOX2
    Clone
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    OriGene ORF clones in mouse, rat for QSOX2
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for QSOX2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat QSOX2
    Sirion Biotech Customized lentivirus for stable overexpression of QSOX2 
                         Customized lentivirus expression plasmids for stable overexpression of QSOX2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QSOX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QSOX2

    Additional mRNA sequence: 

    AJ318051.1 AJ420461.1 AK128077.1 AK128750.1 AL834369.1 BC047604.2 

    6 DOTS entries:

    DT.110458  DT.97836908  DT.97775695  DT.40213602  DT.75100956  DT.121194112 

    24/91 AceView cDNA sequences (see all 91):

    AI742021 BE349598 AI028313 BE875636 BI492379 AI280985 BQ187181 CR601649 
    H08428 AI304528 AA514465 AI309245 AI753180 AA493143 AK128077 AA834579 
    BM352043 BQ894697 BQ953575 AL834369 AA325875 AW515514 BU175119 AI056976 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for QSOX2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                            -     -                             -           -               
    SP2:                                                  -                             -           -               
    SP3:                                                                                -           -               
    SP4:                                                                                                            
    SP5:                    -     -                 -     -                                                         


    ECgene alternative splicing isoforms for QSOX2

    Expression
    for QSOX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    QSOX2 expression in normal human tissues (normalized intensities)      QSOX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGTCAG
    QSOX2 Expression
    About this image


    QSOX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See QSOX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for QSOX2

    SOURCE GeneReport for Unigene cluster: Hs.144073

    UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7
    Tissue specificity: Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in
    lung, liver and skeletal muscles

        SABiosciences Custom PCR Arrays for QSOX2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QSOX2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QSOX2

    Orthologs
    for QSOX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for QSOX2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Qsox21 , 5 quiescin Q6 sulfhydryl oxidase 21, 5 81.69(n)1
    82.57(a)1    		   2 (18.45 cM)5
    2276381  NM_153559.21  NP_705787.11 
     262086375 
    chicken
    (Gallus gallus)    		 Aves QSOX21 quiescin Q6 sulfhydryl oxidase 2 67.59(n)
    67.54(a)    		   417129  XM_415413.2  XP_415413.2 
    lizard
    (Anolis carolinensis)    		 Reptilia QSOX26
    		 Uncharacterized protein
    		 56(a)
    		 1 ↔ 1
    		 GL344237.1(39845-53936)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.76912 Xenopus laevis transcribed sequence with weak similarity more 73.84(n)    BJ073005.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5596031 sulfhydryl oxidase 2-like 60.32(n)
    58.44(a)    		   559603  XM_682961.5  XP_688053.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG178431 CG17843 45.47(n)
    33.74(a)    		   42583  NM_142741.3  NP_650998.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea T10H10.26
    F35G2.16
    (see all 3)    		 Protein F35G2.1, isoform a
    (see all 3)    		 26(a)
    21(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 X(2294750-2298194)
    IV(12200978-12207930)


    ENSEMBL Gene Tree for QSOX2 (if available)
    TreeFam Gene Tree for QSOX2 (if available)

    Paralogs
    for QSOX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for QSOX2 gene
    QSOX12  
    2 SIMAP similar genes for QSOX2 using alignment to 2 protein entries:     QSOX2_HUMAN (see all proteins):
    QSCN6    QSOX1

    QSOX2 for paralogs           About GeneDecksing



    Genomic Variants
    for QSOX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1147 SNPs in QSOX2 are shown (see all 1147)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1433929321,2
    		C--139098961(+) ACACCA/GCTCCC 1 -- ut310--------
    rs37801901,2
    		C,F,A,H--139099073(+) AAGCGA/GCAACA 1 -- ut3126Minor allele frequency- G:0.47NS EA NA CSA WA 2766
    rs1483845721,2
    		C--139099127(+) CAACTC/TGTTAG 1 -- ut310--------
    rs1421302531,2
    		--139099169(+) AAAGCA/GGAAAA 1 -- ut310--------
    rs1834383691,2
    		--139099188(+) CAACCA/GTCAAA 1 -- ut310--------
    rs1461987131,2
    		C--139099211(+) CTCAT-/ACAC  
                ACACA     		1 -- ut310--------
    rs605177751,2
    		C--139099245(+) CACAC-/ACAC  
                GGGCA     		1 -- ut311Minor allele frequency- ACAC:0.00NA 2
    rs1858205441,2
    		--139099267(+) CATCTA/GAGCCT 1 -- ut310--------
    rs1463536111,2
    		--139099300(+) CCTGTC/GAGACA 1 -- ut310--------
    rs1906221501,2
    		--139099383(+) GGCAAC/TGGACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for QSOX2 (139098179 - 139137687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for QSOX2 (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739342CNV Deletion23290073
    esv2739343CNV Deletion23290073
    esv2739344CNV Deletion23290073
    esv1030583CNV Insertion17803354
    esv1053090CNV Insertion17803354
    esv993665CNV Insertion20482838
    nsv513002CNV Insertion21212237
    nsv416548CNV Insertion16902084
    dgv8388n71CNV Loss21882294
    nsv894322CNV Loss21882294

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    Disorders / Diseases
    for QSOX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 612860    OMIM disorders: --

    3 diseases for QSOX2:    About MalaCards
    neuroblastoma    skin disease    infertility


    QSOX2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): QSOX2
    Human Genome Epidemiology (HuGE) Navigator: QSOX2 (1 document)

    Export disorders for QSOX2 gene to outside databases

    Publications
    for QSOX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for QSOX2 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with QSOX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/quiescin 6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells. (PubMed id 14633699)1, 2, 9 Wittke I....Schwab M. (2003)
    2. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. (PubMed id 12176051)1, 3, 9 Thorpe C....Coppock D.L. (2002)
    3. A genome-wide association study in 19 633 Japanese su bjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1, 4 Okada Y....Kamatani N. (2010)
    4. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    7. The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Replication study of the association of SNPs in the LH X3-QSOX2 and IGF1 loci with adult height in the Japanese population; wide-rangin g comparison of each SNP genotype distribution. (PubMed id 22503243)1 Fujihara J....Yasuda T. (2012)
    10. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O....Lill R. (2012)

    External Searches for QSOX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing QSOX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 169714 HGNC: 30249 AceView: QSCN6L1 Ensembl:ENSG00000165661 euGenes: HUgn169714
    ECgene: QSOX2 H-InvDB: QSOX2

    Other Databases showing QSOX2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing QSOX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for QSOX2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for QSOX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for QSOX2 gene:
    Search GeneIP for patents involving QSOX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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