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Aliases & Descriptions for QSOX2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp762A2013 1, 2 | | EC 1.8.3.2 3 | | OTTHUMP00000022565 2 | | QSCN6L1 2, 3 | | SOXN 1, 2, 3 |
| | | Descriptions |
|---|
| Neuroblastoma-derived sulfhydryl oxidase 2, 3 | | Quiescin Q6-like protein 1 3 | | quiescin Q6 sulfhydryl oxidase 2 2 | | quiescin Q6-like 1 1, 2 |
|
| | Search outside databases for aliases for QSOX2 genePrevious GC identifer: GC09M137879 |
Summaries for QSOX2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis |
Genomic Location for QSOX2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3QSOX2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M138239:
(about GC identifiers)
Start:
|
138,238,000 bp from pter |
End:
|
138,277,508 bp from pter |
Size:
|
39,509 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_019501.13
| Proteins for QSOX2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7 (See
protein sequence)Recommended Name: Sulfhydryl oxidase 2 precursor Size: 698 amino acids; 77529 Da
Cofactor: Binds 1 FAD per subunit (Potential)
Subcellular location: Membrane; Single-pass membrane protein. Secreted. Cell membrane; Single-pass membrane protein (Potential). Nucleus membrane; Single-pass membrane protein (Potential). Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane
Sequence caution: Sequence=CAC85331.1; Type=Frameshift; Positions=354, 369, 616, 618;
Secondary accessions: A2CEE0 A6NLB0 Q5TB37 Q7Z7B6 Q86VV7 Q8N3G2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_859052.3
ENSEMBL proteins: ENSP00000351536 ENSP00000374122
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for QSOX2: Assays for QSOX2: | Protein
Domains/ Families for QSOX2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6ZRP7
ProtoNet protein and cluster: Q6ZRP7 2 Blocks protein families: IPB006662 Thioredoxin type domain IPB006863 Erv1/Alr
UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7Similarity: Belongs to the quiescin-sulfhydryl oxidase (QSOX) familySimilarity: Contains 1 ERV/ALR sulfhydryl oxidase domainSimilarity: Contains 1 thioredoxin domain | Gene Function for QSOX2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181701
Applied Biosystems Silencer® siRNAs for QSOX2
Sigma-Aldrich siRNA and siRNA Panels for QSOX2  Sigma-Aldrich shRNA for QSOX2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_181701                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_181701                                  untagged cDNA clone in CMV expression vector: NM_181701 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_181701
UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosisCatalytic activity: 4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)OEnzyme Number (IUBMB): EC 1.8.3.2 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016491 | oxidoreductase activity |
IEA | -- | | GO:0016972 | thiol oxidase activity |
IEA | -- | About this table | Pathways & Interactions for QSOX2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045454 | cell redox homeostasis |
IEA | -- | | GO:0055114 | oxidation reduction |
IEA | -- | About this table
|
Drugs & Compounds for QSOX2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for QSOX2 2 Novoseek chemical compound relationships for QSOX2 gene
About this table
|
Transcripts for QSOX2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181701
Sigma-Aldrich siRNA and siRNA Panels for QSOX2  Sigma-Aldrich shRNA for QSOX2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_181701 REFSEQ mRNAs for QSOX2 gene: NM_181701.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_181701               OriGene GFP tagged cDNA clone in CMV expression vector: NM_181701                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_181701                                  untagged cDNA clone in CMV expression vector: NM_181701  Additional cDNA sequence: AJ318051.1 AJ420461.1 AK128077.1 AK128750.1 AL834369.1 BC047604.2 CR601649.1 6 DOTS entries: DT.110458 DT.97836908 DT.97775695 DT.75100956 DT.40213602 DT.121194112 24/91 AceView cDNA sequences (see all 91
):AA514465 AI742021 AA493143 BI492379 AI304528 BE875636 BQ187181 AI753180 CR601649 BE349598 AI028313 AI280985 H08428 AI309245 BM352357 BU175119 BG180984 BG745598 AW515514 AW873348 BQ227274 BQ185744 BQ953575 AI056976 Unigene Cluster for QSOX2: Quiescin Q6 sulfhydryl oxidase 2 Hs.657864 [show with all ESTs]Unigene Representative Sequence: AJ318051
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for QSOX2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for QSOX2
2 Ensembl transcripts including schematic representations: ENST00000358701
ENST00000389471
|
Expression for QSOX2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| QSOX2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for QSOX2
1 / 2 6 probe-sets matching QSOX2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAAATGTCAG
SOURCE GeneReport for Unigene cluster: Hs.657864 UniProtKB/Swiss-Prot: QSOX2_HUMAN, Q6ZRP7Tissue specificity: Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles |
Orthologs for QSOX2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for QSOX2 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for QSOX2
ENSEMBL Gene Tree for QSOX2 | Paralogs for QSOX2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for QSOX2 gene
- QSOX12
|
SNPs/Variants for QSOX2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for QSOX2 (up to first 250kb)
|
Disorders & Mutations for QSOX2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for QSOX2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for QSOX2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/34 PubMed articles for QSOX2 gene (see all 34
):- Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/quiescin 6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells. (PubMed id 14633699)1, 3, 4 Wittke I....Schwab M. (2003)
- Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. (PubMed id 12176051)1, 2, 3 Thorpe C....Coppock D.L. (2002)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)3, 4 Humphray S.J.... Dunham I. (2004)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)4 Daub H.... Mann M. (2008)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases. (PubMed id 10542195)1 Hoober K.L.... Thorpe C. (1999)
- The potentiation role of hepatopoietin on activator protein-1 is dependent on its sulfhydryl oxidase activity. (PubMed id 14500725)1 Chen X....He F. (2003)
|
Search for QSOX2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing QSOX2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing QSOX2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QSOX2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for QSOX2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for QSOX2:

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Incremental update: 13 Oct 2009
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