QSOX2 Gene

Aliases
for QSOX2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC09M138239 GC09M137879 GC09M108562

Summaries
for QSOX2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for QSOX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000009.11  NC_018920.2  NT_008470.20  

SwitchGear Promoter luciferase reporter plasmid: QSOX2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat QSOX2

QSOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139098:  view genomic region     (about GC identifiers)

Proteins
for QSOX2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for QSOX2: NX_Q6ZRP7

Explore proteomics data for QSOX2 at MOPED

Post-translational modifications: 

QSOX2 Human Recombinant Protein Products:

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	antibodies-online peptides for QSOX2

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QSOX2 Assay Products:

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	antibodies-online kits for QSOX2 (4 products)

Domains /
Families
for QSOX2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q6ZRP7

Find genes that share domains with QSOX2           About GenesLikeMe

Function
for QSOX2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Number (IUBMB): EC 1.8.3.2¹

     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for QSOX2

miRNA Products:		miRTarBase miRNAs that target QSOX2: hsa-mir-340-5p (MIRT019576), hsa-mir-16-5p (MIRT031819), hsa-mir-92a-3p (MIRT049168), hsa-mir-17-3p (MIRT050770), hsa-mir-125b-5p (MIRT004986)
		Block miRNA regulation of human, mouse, rat QSOX2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate QSOX2 (see all 18):
		hsa-miR-320a hsa-miR-607 hsa-miR-125a-5p hsa-miR-605 hsa-miR-500a hsa-miR-105 hsa-miR-125b hsa-miR-103a-2*
		SwitchGear 3'UTR luciferase reporter plasmid: QSOX2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for QSOX2
		Predesigned siRNA for gene silencing in human, mouse, rat QSOX2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for QSOX2

Clone Products:		OriGene clones in human, mouse for QSOX2 (see all 6) OriGene ORF clones in mouse, rat for QSOX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: QSOX2 (NM_181701)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for QSOX2
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat QSOX2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for QSOX2
		Browse ESI BIO Cell Lines and PureStem Progenitors for QSOX2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QSOX2

Localization
for QSOX2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
nucleus	5
plasma membrane	5
endoplasmic reticulum	2
cytosol	1
golgi apparatus	1
lysosome	1
mitochondrion	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for QSOX2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for QSOX2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for QSOX2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for QSOX2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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QSOX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAATGTCAG

About this image

Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Ovary (Reproductive System)    fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Pancreas (Endocrine System)
Islets of Langerhans
Testis (Reproductive System)
Leydig Cells Testis Interstitium

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for QSOX2
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat QSOX2
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		QuantiFast Probe-based Assays in human, mouse, rat QSOX2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QSOX2

Orthologs
for QSOX2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for QSOX2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for QSOX2 gene

QSOX1²  

2 SIMAP similar genes for QSOX2 using alignment to 2 protein entries:     QSOX2_HUMAN (see all proteins):

QSCN6    QSOX1

Find genes that share paralogs with QSOX2           About GenesLikeMe

Genomic Variants
for QSOX2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for QSOX2 (see all 1147)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1433929321,2	C	--	139098961(+)	ACACCA/GCTCCC	1	--	ut31		0	--	--	--	--
rs37801901,2	C,F,A,H	--	139099073(+)	AAGCGA/GCAACA	1	--	ut31		26		NS EA NA CSA WA	2766
rs1483845721,2	C	--	139099127(+)	CAACTC/TGTTAG	1	--	ut31		0	--	--	--	--
rs1421302531,2		--	139099169(+)	AAAGCA/GGAAAA	1	--	ut31		0	--	--	--	--
rs1834383691,2		--	139099188(+)	CAACCA/GTCAAA	1	--	ut31		0	--	--	--	--
rs1461987131,2	C	--	139099211(+)	CTCAT-/ACAC           ACACA	1	--	ut31		0	--	--	--	--
rs605177751,2	C	--	139099245(+)	CACAC-/ACAC           GGGCA	1	--	ut31		1		NA	2
rs1858205441,2		--	139099267(+)	CATCTA/GAGCCT	1	--	ut31		0	--	--	--	--
rs1463536111,2		--	139099300(+)	CCTGTC/GAGACA	1	--	ut31		0	--	--	--	--
rs1906221501,2		--	139099383(+)	GGCAAC/TGGACC	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for QSOX2 (139098179 - 139137687 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for QSOX2 (see all 22):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2739342	CNV	Deletion	23290073
esv2739343	CNV	Deletion	23290073
esv2739344	CNV	Deletion	23290073
esv1030583	CNV	Insertion	17803354
esv1053090	CNV	Insertion	17803354
esv993665	CNV	Insertion	20482838
nsv513002	CNV	Insertion	21212237
nsv416548	CNV	Insertion	16902084
dgv8388n71	CNV	Loss	21882294
nsv894322	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing QSOX2

DNA2.0 Custom Variant and Variant Library Synthesis for QSOX2

Disorders / Diseases
for QSOX2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for QSOX2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Neuroblastoma-derived sulfhydryl oxidase, a new member of the sulfhydryl oxidase/quiescin 6 family, regulates sensitization to interferon gamma-induced cell death in human neuroblastoma cells. (PubMed id 14633699)^{1, 2, 9} Wittke I....Schwab M. (Cancer Res. 2003)
2. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. (PubMed id 12176051)^{1, 3, 9} Thorpe C....Coppock D.L. (Arch. Biochem. Biophys. 2002)
3. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)^{1, 4} Okada Y....Kamatani N. (Hum. Mol. Genet. 2010)
4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)^{1, 4} Lango Allen H....Hirschhorn J.N. (Nature 2010)
5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (Nature 2004)
7. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)¹ Bett J.S....Hay R.T. (Biochem. J. 2013)
8. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
9. Replication study of the association of SNPs in the LHX3-QSOX2 and IGF1 loci with adult height in the Japanese population; wide-ranging comparison of each SNP genotype distribution. (PubMed id 22503243)¹ Fujihara J....Yasuda T. (Leg Med (Tokyo) 2012)
10. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)¹ Stehling O.... Lill R. (Science 2012)

External Searches for QSOX2 gene

Genome Databases showing QSOX2 gene

Other Databases showing QSOX2 gene

Specialized Databases showing QSOX2 gene

Products
for QSOX2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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