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Aliases & Descriptions for QSOX1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 1.8.3.2 3 FLJ34858 2 OTTHUMP00000033189 2 OTTHUMP00000039111 2 Q6 2 QSCN6 2 , 3 hQSOX 3
Descriptions Quiescin Q6 1 , 3 quiescin Q6 sulfhydryl oxidase 1 2
Search outside databases for aliases for QSOX1 gene
Summaries for QSOX1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
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EntrezGene summary for QSOX1 : This gene encodes a protein that contains domains of thioredoxin and ERV1, members of twolong-standing gene families. The gene expression is induced as fibroblasts begin to exit theproliferative cycle and enter quiescence, suggesting that this gene plays an important role ingrowth regulation. Two transcript variants encoding two different isoforms have been found forthis gene. [provided by RefSeq] UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391 Function : Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfideswith the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in avariety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities beinginvolved in growth regulation
Gene Wiki entry for QSOX1
Genomic Location for QSOX1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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UCSC and
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q24 Ensembl cytogenetic band: 1q25.2 HGNC cytogenetic band: 1q24 QSOX1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P178391:
(about GC identifiers )
Start:
178,390,591 bp from pter
End:
178,447,290 bp from pter
Size:
56,700 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for QSOX1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
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Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391 (See
protein sequence )Recommended Name: Sulfhydryl oxidase 1 precursor Size : 747 amino acids; 82578 Da
Cofactor : Binds 1 FAD per subunit (By similarity)
Subunit : Monomer (By similarity)
Subcellular location : Isoform 1: Golgi apparatus membrane; Single-pass membrane protein
Subcellular location : Isoform 2: Secreted, extracellular space. Note=Found in the extracellularmedium of quiescent cells but is not found in proliferating cells
Miscellaneous : 'Quiescin Q6' means that it was the sixth clone to be found at a higher level ofexpression in quiescent fibroblasts
Secondary accessions : Q59G29 Q5T2X0 Q8TDL6 Q8WVP4Alternative splicing : 2 isoforms : O00391-1 O00391-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001004128.1 NP_002817.2 ENSEMBL proteins: ENSP00000375885 ENSP00000375883 ENSP00000356572 ENSP00000356574 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
):
About this table Antibodies for QSOX1: Assays for QSOX1:
Protein
Domains/ Families for QSOX1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O00391 ProtoNet protein and cluster: O00391
2 Blocks protein families : IPB006662 Thioredoxin type domain IPB006863 Erv1/Alr UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391 Similarity : Belongs to the quiescin-sulfhydryl oxidase (QSOX) familySimilarity : Contains 1 ERV/ALR sulfhydryl oxidase domainSimilarity : Contains 1 thioredoxin domain
Gene Function for QSOX1
(According to MGI Jun 06 2009, UniProtKB ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001004128 Applied Biosystems Silencer ® siRNAs for QSOX1 Sigma-Aldrich siRNA and siRNA Panels for QSOX1 Sigma-Aldrich shRNA for QSOX1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001004128                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001004128                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001004128  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002826 UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391 Function : Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfideswith the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in avariety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities beinginvolved in growth regulation Catalytic activity : 4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)OInduction : Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycleand enter quiescence Enzyme Number (IUBMB): EC 1.8.3.2
2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016491 oxidoreductase activity
IEA -- GO:0016971 flavin-linked sulfhydryl oxidase activity
IGI 17331072
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Pathways & Interactions for QSOX1
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Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Interacting proteins for QSOX1 (ENSP00000356574 3 O00391 2 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Transcripts for QSOX1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001004128 Sigma-Aldrich siRNA and siRNA Panels for QSOX1 Sigma-Aldrich shRNA for QSOX1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001004128 NM_002826
REFSEQ mRNAs for QSOX1 gene (2 alternative transcripts): NM_001004128.2 NM_002826.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001004128 NM_002826
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001004128                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001004128                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001004128  
Additional cDNA sequence: AB209280.1 AF361868.1 AK074447.1 AK290842.1 AK290887.1 AL832927.1 AY358941.1 BC017692.1 BC100023.1 CR597598.1 CR601148.1 CR613263.1 CR619667.1 U97276.2
24/43 DOTS entries (see all 43
): DT.100829879 DT.100059508 DT.99973359 DT.92440983 DT.102840166 DT.86855929 DT.86841789 DT.97759904 DT.100724595 DT.101967478 DT.99968131 DT.102840180 DT.100691414 DT.121434083 DT.100053977 DT.121434161 DT.102840170 DT.102840174 DT.102844889 DT.91750186 DT.102840182 DT.92440981 DT.100654003 DT.100654006
24/1123 AceView cDNA sequences (see all 1123
):BQ920061 AI250666 BM561487 CO248497 BQ007832 CA488461 NM_002826 CO248765 BM773007 BQ684306 BM771903 BM773008 BQ422933 CF125105 CF132132 BU944785 CF132176 CA309936 CA390872 AI188675 AU077242 AI986162 CA489847 CO249430
Unigene Cluster for QSOX1: Quiescin Q6 sulfhydryl oxidase 1 Hs.719176 [show with all ESTs ] Unigene Representative Sequence: NM_002826 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for QSOX1 (see all 9
) ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b SP1 :     -                               -   -       SP2 :     -                                       SP3 :         -                                   SP4 :     -   -   -   -   -   -   -                           SP5 :   -   -                                      
About this scheme ECgene alternative splicing isoforms for QSOX1 4 Ensembl transcripts including schematic representations : ENST00000392031
ENST00000392029
ENST00000367600
ENST00000367602
Expression for QSOX1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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QSOX1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for QSOX1 1 / 2
3 probe-sets matching QSOX1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.719176 UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391 Tissue specificity : Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and veryweakly in brain and kidney
Orthologs for QSOX1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for QSOX1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for QSOX1 ENSEMBL Gene Tree for QSOX1 Paralogs for QSOX1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for QSOX1 gene QSOX2 2
SNPs/Variants for QSOX1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for QSOX1 (up to first 250kb)
Disorders & Mutations for QSOX1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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and/or TGDB .)
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OMIM: 603120 1 Novoseek disease relationship for QSOX1 gene
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer
16.97
1
9878249 (1)
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Medical News for QSOX1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for QSOX1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/25 PubMed articles for QSOX1 gene (see all 25
): The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. (PubMed id 9878249) 1, 2, 3, 4 Coppock D.L.... Gilleran S. (1998) Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. (PubMed id 10708601) 1, 3, 4 Coppock D.L.... Cina-Poppe D.A. (2000) Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases. (PubMed id 10542195) 1, 3, 4 Hoober K.L.... Thorpe C. (1999) Preferential gene expression in quiescent human lung fibroblasts. (PubMed id 8396966) 1, 2, 3 Coppock D.L....Gilleran S. (1993) Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1. (PubMed id 17331072) 3, 4 Chakravarthi S.... Bulleid N.J. (2007) Identification and expression of a new splicing variant of FAD- sulfhydryl oxidase in adult rat brain. (PubMed id 16806532) 3, 4 Radom J.... Jouvenot M. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952) 3, 4 Liu T.... Smith R.D. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 3, 4 Clark H.F....Gray A. (2003)
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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