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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

QSOX1 Gene

protein-coding   GIFtS: 56
GCID: GC01P180123

Quiescin Q6 Sulfhydryl Oxidase 1

(Previous name: quiescin Q6)
(Previous symbol: QSCN6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Quiescin Q6 Sulfhydryl Oxidase 11 2     EC 1.8.3.23 8
QSCN61 2 3     Q62
Quiescin Q61 3     Sulfhydryl Oxidase 12
hQSOX2 3     

External Ids:    HGNC: 97561   Entrez Gene: 57682   Ensembl: ENSG000001162607   OMIM: 6031205   UniProtKB: O003913   

Export aliases for QSOX1 gene to outside databases

Previous GC identifers: GC01P178391 GC01P151355


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for QSOX1 Gene:
This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene
families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter
quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants
encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for QSOX1 Gene: 
QSOX1 (quiescin Q6 sulfhydryl oxidase 1) is a protein-coding gene. Diseases associated with QSOX1 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include protein disulfide isomerase activity and flavin-linked sulfhydryl oxidase activity. An important paralog of this gene is QSOX2.

UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391
Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the
reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted
proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation

Gene Wiki entry for QSOX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the QSOX1 gene promoter:
         Spz1   IRF-2   POU2F1   AML1a   POU2F1a   Cart-1   IRF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQSOX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for QSOX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QSOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q24

QSOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QSOX1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P180123:  view genomic region     (about GC identifiers)

Start:
180,123,968 bp from pter      End:
180,173,165 bp from pter
Size:
49,198 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391 (See protein sequence)
Recommended Name: Sulfhydryl oxidase 1 precursor  
Size: 747 amino acids; 82578 Da
Cofactor: Binds 1 FAD per subunit
Subunit: Monomer
Subcellular location: Isoform 1: Golgi apparatus membrane; Single-pass membrane protein
Subcellular location: Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of
quiescent cells but is not found in proliferating cells
Miscellaneous: 'Quiescin Q6' means that it was the sixth clone to be found at a higher level of expression in
quiescent fibroblasts
Sequence caution: Sequence=BAD92517.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for QSOX1:
3LLI (3D)        3LLK (3D)        3Q6O (3D)    
Secondary accessions: Q59G29 Q5T2X0 Q8TDL6 Q8WVP4
Alternative splicing: 2 isoforms:  O00391-1   O00391-2   

Explore the universe of human proteins at neXtProt for QSOX1: NX_O00391

Explore proteomics data for QSOX1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00391

  • 4/6 DME Specific Peptides for QSOX1 (O00391) (see all 6)
     FPKVQWP  SWCGHCI  EDPQFPK  LFHFLTVQA 

    QSOX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    QSOX1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001004128.1  NP_002817.2  

    ENSEMBL proteins: 
     ENSP00000356574   ENSP00000375883   ENSP00000356572   ENSP00000402170  

    Human Recombinant Protein Products for QSOX1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for QSOX1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA10708601
    GO:0030173integral to Golgi membrane IDA17331072

    QSOX1 for ontologies           About GeneDecksing



    QSOX1 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for QSOX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR017905 ERV/ALR_sulphydryl_oxidase
     IPR012336 Thioredoxin-like_fold
     IPR006863 Evr1_Alr
     IPR013766 Thioredoxin_domain

    Graphical View of Domain Structure for InterPro Entry O00391

    ProtoNet protein and cluster: O00391

    2 Blocks protein domains:
    IPB006662 Thioredoxin type domain
    IPB006863 Erv1/Alr


    UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391
    Similarity: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family
    Similarity: Contains 1 ERV/ALR sulfhydryl oxidase domain
    Similarity: Contains 1 thioredoxin domain


    QSOX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QSOX1_HUMAN, O00391
    Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the
    reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted
    proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation
    Catalytic activity: 2 R'C(R)SH + O(2) = R'C(R)S-S(R)CR' + H(2)O(2)
    Induction: Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycle and enter
    quiescence

         Enzyme Number (IUBMB): EC 1.8.3.21 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IGI17331072
    GO:0009055electron carrier activity ----
    GO:0015035protein disulfide oxidoreductase activity ----
    GO:0016971flavin-linked sulfhydryl oxidase activity IGI17331072
    GO:0016972thiol oxidase activity ----
         
    QSOX1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for QSOX1:
     Decreased Salmonella enterica   Increased cell death in breast  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for QSOX1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for QSOX1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for QSOX1 

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    SwitchGear 3'UTR luciferase reporter plasmidQSOX1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QSOX1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QSOX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for QSOX1 (O003912, 3 ENSP000003565744) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2862369 I2D: score=2 STRING: ENSP00000357292
    SCN2BENSP000002789474STRING: ENSP00000278947
    UBE2D2ENSP000003817174STRING: ENSP00000381717
    BEGAINENSP000003473014STRING: ENSP00000347301
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IGI17331072
    GO:0006662glycerol ether metabolic process ----
    GO:0045454cell redox homeostasis IEA--
    GO:0055114oxidation-reduction process ----

    QSOX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for QSOX1

    3 HMDB Compounds for QSOX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about QSOX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for QSOX1 gene (2 alternative transcripts): 
    NM_001004128.2  NM_002826.4  

    Unigene Cluster for QSOX1:

    Quiescin Q6 sulfhydryl oxidase 1
    Hs.744925  [show with all ESTs]
    Unigene Representative Sequence: NM_002826
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367602(uc001gny.3 uc001gnz.3) ENST00000392029 ENST00000367600
    ENST00000443059
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate QSOX1 (see all 9):
    hsa-miR-495 hsa-miR-7-2* hsa-miR-4290 hsa-miR-3692 hsa-miR-124 hsa-miR-7-1* hsa-miR-506 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidQSOX1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209280.1 AF361868.1 AK290842.1 AK290887.1 AY358941.1 BC017692.1 BC100023.1 U97276.2 

    24/40 DOTS entries (see all 40):

    DT.100829879  DT.99973359  DT.92440983  DT.100059508  DT.102840166  DT.86855929  DT.86841789  DT.97759904 
    DT.100724595  DT.101967478  DT.99968131  DT.102840180  DT.100691414  DT.121434083  DT.100053977  DT.102840170 
    DT.102840174  DT.102844889  DT.91750186  DT.102840182  DT.92440981  DT.100654003  DT.100654006  DT.100654010 

    24/1123 AceView cDNA sequences (see all 1123):

    BM771248 CF125412 CF125436 BM772993 NM_001004128 AI358823 BM561487 AI469130 
    AW241861 BU733310 AI910564 BQ920061 BQ878559 CB528946 BU628864 BQ953099 
    AA947617 CF125626 CF125424 BM771261 CF132176 CO247678 CF132132 CA390872 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for QSOX1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b
    SP1:              -                                                                                         -     -               
    SP2:              -                                                                                                               
    SP3:                          -                                                                                                   
    SP4:              -     -     -     -     -     -     -                                                                           
    SP5:        -     -                                                                                                               


    ECgene alternative splicing isoforms for QSOX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    QSOX1 expression in normal human tissues (normalized intensities)      QSOX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGATTCCC
    QSOX1 Expression
    About this image


    QSOX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)
             optic nerve head astrocytes   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Liver (Hepatobiliary System)
             Human Mesenchymal Stem Cell-hepatic (HMSC-he)   
     
     Blood (Hematopoietic System)
             monocyte-derived dendritic cells   
     
     Mesenchymal Stem Cells
             Human Mesenchymal Stem Cell-hepatic (HMSC-he)   

    See QSOX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for QSOX1

    SOURCE GeneReport for Unigene cluster: Hs.744925

    UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391
    Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain
    and kidney

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QSOX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for QSOX1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Qsox11 , 5 quiescin Q6 sulfhydryl oxidase 11, 5 78.77(n)1
    73.41(a)1
      1 (67.64 cM)5
    1040091  NM_001024945.11  NP_001020116.11 
     1557781555 
    chicken
    (Gallus gallus)
    Aves QSOX11 quiescin Q6 sulfhydryl oxidase 1 62.29(n)
    54.4(a)
      373914  NM_204125.1  NP_989456.1 
    lizard
    (Anolis carolinensis)
    Reptilia QSOX16
    quiescin Q6 sulfhydryl oxidase 1
    40(a)
    1 ↔ 1
    4(70392296-70481159)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX720504.12   -- 78.47(n)    BX720504.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb8402 sbcb840 71.44(n)   378857  57048593 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46701 CG4670 46.5(n)
    34.4(a)
      36464  NM_137008.2  NP_610852.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T10H10.21 Protein T10H10.2 41.2(n)
    33.68(a)
      180538  NM_076018.2  NP_508419.1 


    ENSEMBL Gene Tree for QSOX1 (if available)
    TreeFam Gene Tree for QSOX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for QSOX1 gene
    QSOX22  
    4 SIMAP similar genes for QSOX1 using alignment to 3 protein entries:     QSOX1_HUMAN (see all proteins):
    QSCN6    QSOX2    PDIA3    PDIA5

    QSOX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1028 SNPs in QSOX1 are shown (see all 1028)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0536524
    ----see VAR_0536522 R P mis40--------
    VAR_0274344
    ----see VAR_0274342 N H mis40--------
    rs1155096961,2
    C,F--180122086(+) CCTAAC/TCCAGA 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1124412271,2
    F--180122339(+) AGTGCC/TGCAAT 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs115895191,2
    C,F,A,H--180122390(+) CAAGGC/TCTATC 2 -- us2k19Minor allele frequency- T:0.48NA WA EA 370
    rs1509612191,2
    C--180122468(+) ATGTCC/GTTGTT 2 -- us2k10--------
    rs75301681,2
    C,F,A--180122575(+) AGCACT/CACATT 2 -- us2k17Minor allele frequency- C:0.20NA WA CSA EA 366
    rs75277331,2
    C,H--180122578(+) ACTACG/ATTCGA 2 -- us2k112Minor allele frequency- A:0.05NA WA CSA EA 256
    rs1406615601,2
    --180122579(+) CTACAC/TTCGAG 2 -- us2k10--------
    rs75162571,2
    C,F,A,H--180122812(+) cacctC/Tctctg 2 -- us2k117Minor allele frequency- T:0.12NS EA NA WA CSA 1968

    HapMap Linkage Disequilibrium report for QSOX1 (180123968 - 180173165 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for QSOX1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv872574CNV Loss21882294
    nsv528041CNV Loss19592680
    nsv522045CNV Loss19592680
    nsv832004CNV Gain17160897
    nsv466239CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603120    OMIM disorders: --

    7 diseases for QSOX1:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    insulin resistance    prostate cancer
    prostatitis    endotheliitis    breast cancer


    QSOX1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for QSOX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 26.8 1 9878249 (1)
    tumors 0 1 19597465 (1)


    Export disorders for QSOX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for QSOX1 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with QSOX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. (PubMed id 9878249)1, 2, 3, 9 Coppock D.L.... Gilleran S. (1998)
    2. Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. (PubMed id 10708601)1, 2, 9 Coppock D.L.... Cina-Poppe D.A. (2000)
    3. Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases. (PubMed id 10542195)1, 2, 9 Hoober K.L.... Thorpe C. (1999)
    4. Preferential gene expression in quiescent human lung fibroblasts. (PubMed id 8396966)1, 3, 9 Coppock D.L....Gilleran S. (1993)
    5. QSOX contains a pseudo-dimer of functional and degene rate sulfhydryl oxidase domains. (PubMed id 20211621)1, 2 Alon A....Fass D. (2010)
    6. Human quiescin-sulfhydryl oxidase, QSOX1: probing internal redox steps by mutagenesis. (PubMed id 18393449)1, 2 Heckler E.J....Thorpe C. (2008)
    7. Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1. (PubMed id 17331072)1, 2 Chakravarthi S.... Bulleid N.J. (2007)
    8. Identification and expression of a new splicing variant of FAD- sulfhydryl oxidase in adult rat brain. (PubMed id 16806532)1, 2 Radom J.... Jouvenot M. (2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5768 HGNC: 9756 AceView: QSCN6 Ensembl:ENSG00000116260 euGenes: HUgn5768
    ECgene: QSOX1 H-InvDB: QSOX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for QSOX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for QSOX1 gene:
    Search GeneIP for patents involving QSOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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