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Aliases for QSOX1 Gene

Aliases for QSOX1 Gene

  • Quiescin Q6 Sulfhydryl Oxidase 1 2 3
  • Quiescin Q6 2 4
  • EC 1.8.3.2 4 63
  • QSCN6 3 4
  • HQSOX 3 4
  • Sulfhydryl Oxidase 1 3
  • Q6 3

External Ids for QSOX1 Gene

Previous HGNC Symbols for QSOX1 Gene

  • QSCN6

Previous GeneCards Identifiers for QSOX1 Gene

  • GC01P178391
  • GC01P180123
  • GC01P151355

Summaries for QSOX1 Gene

Entrez Gene Summary for QSOX1 Gene

  • This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for QSOX1 Gene

QSOX1 (Quiescin Q6 Sulfhydryl Oxidase 1) is a Protein Coding gene. GO annotations related to this gene include protein disulfide isomerase activity and flavin-linked sulfhydryl oxidase activity. An important paralog of this gene is QSOX2.

UniProtKB/Swiss-Prot for QSOX1 Gene

  • Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.

Gene Wiki entry for QSOX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QSOX1 Gene

Genomics for QSOX1 Gene

Regulatory Elements for QSOX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for QSOX1 Gene

Start:
180,154,833 bp from pter
End:
180,204,030 bp from pter
Size:
49,198 bases
Orientation:
Plus strand

Genomic View for QSOX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for QSOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QSOX1 Gene

Proteins for QSOX1 Gene

  • Protein details for QSOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00391-QSOX1_HUMAN
    Recommended name:
    Sulfhydryl oxidase 1
    Protein Accession:
    O00391
    Secondary Accessions:
    • Q59G29
    • Q5T2X0
    • Q8TDL6
    • Q8WVP4

    Protein attributes for QSOX1 Gene

    Size:
    747 amino acids
    Molecular mass:
    82578 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • Quiescin Q6 means that it was the sixth clone to be found at a higher level of expression in quiescent fibroblasts
    SequenceCaution:
    • Sequence=BAD92517.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for QSOX1 Gene

    Alternative splice isoforms for QSOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QSOX1 Gene

Proteomics data for QSOX1 Gene at MOPED

Selected DME Specific Peptides for QSOX1 Gene

Post-translational modifications for QSOX1 Gene

  • Glycosylation at Asn130, Asn243, Thr276, Thr277, Thr281, Thr282, Thr289, Ser493, Ser549, Asn575, Ser576, Thr577, Ser588, Thr590, Thr592, Thr593, Ser604, Ser643, Thr647, and Ser655
  • Modification sites at PhosphoSitePlus

Other Protein References for QSOX1 Gene

Antibody Products

Domains for QSOX1 Gene

Suggested Antigen Peptide Sequences for QSOX1 Gene

Graphical View of Domain Structure for InterPro Entry

O00391

UniProtKB/Swiss-Prot:

QSOX1_HUMAN :
  • O00391
Domain:
  • Contains 1 ERV/ALR sulfhydryl oxidase domain.
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
genes like me logo Genes that share domains with QSOX1: view

No data available for Gene Families for QSOX1 Gene

Function for QSOX1 Gene

Molecular function for QSOX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2 RC(R)SH + O(2) = RC(R)S-S(R)CR + H(2)O(2).
UniProtKB/Swiss-Prot Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.
UniProtKB/Swiss-Prot Induction: Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycle and enter quiescence.

Enzyme Numbers (IUBMB) for QSOX1 Gene

Gene Ontology (GO) - Molecular Function for QSOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IGI 17331072
GO:0016971 flavin-linked sulfhydryl oxidase activity IGI 17331072
GO:0016972 thiol oxidase activity --
genes like me logo Genes that share ontologies with QSOX1: view
genes like me logo Genes that share phenotypes with QSOX1: view

Animal Model Products

miRNA for QSOX1 Gene

miRTarBase miRNAs that target QSOX1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for QSOX1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for QSOX1 Gene

Localization for QSOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QSOX1 Gene

Isoform 1: Golgi apparatus membrane; Single-pass membrane protein.
Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QSOX1 Gene COMPARTMENTS Subcellular localization image for QSOX1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for QSOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 10708601
GO:0005794 Golgi apparatus IDA --
GO:0030173 integral component of Golgi membrane IDA 17331072
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with QSOX1: view

Pathways for QSOX1 Gene

SuperPathways for QSOX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for QSOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IGI 17331072
GO:0016242 negative regulation of macroautophagy IMP 24475161
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with QSOX1: view

No data available for Pathways by source for QSOX1 Gene

Compounds for QSOX1 Gene

(3) HMDB Compounds for QSOX1 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with QSOX1: view

Transcripts for QSOX1 Gene

Unigene Clusters for QSOX1 Gene

Quiescin Q6 sulfhydryl oxidase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for QSOX1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for QSOX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for QSOX1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - - -
SP5: - -
SP6: - - -
SP7: -
SP8:
SP9: -

Relevant External Links for QSOX1 Gene

GeneLoc Exon Structure for
QSOX1
ECgene alternative splicing isoforms for
QSOX1

Expression for QSOX1 Gene

mRNA expression in normal human tissues for QSOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for QSOX1 Gene

SOURCE GeneReport for Unigene cluster for QSOX1 Gene Hs.744925

mRNA Expression by UniProt/SwissProt for QSOX1 Gene

O00391-QSOX1_HUMAN
Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.
genes like me logo Genes that share expressions with QSOX1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for QSOX1 Gene

Orthologs for QSOX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for QSOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QSOX1 35
  • 99.28 (n)
  • 98.5 (a)
QSOX1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia QSOX1 35
  • 85.38 (n)
  • 80.11 (a)
QSOX1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QSOX1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qsox1 35
  • 78.59 (n)
  • 73.28 (a)
Qsox1 16
Qsox1 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia QSOX1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QSOX1 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Qsox1 35
  • 79.18 (n)
  • 73.49 (a)
chicken
(Gallus gallus)
Aves QSOX1 35
  • 62.31 (n)
  • 54.63 (a)
QSOX1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QSOX1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qsox1 35
  • 51.78 (n)
  • 44.23 (a)
zebrafish
(Danio rerio)
Actinopterygii qsox1 35
  • 53.4 (n)
  • 45.55 (a)
qsox1 36
  • 38 (a)
OneToOne
sbcb840 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007491 35
  • 47.46 (n)
  • 35.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17843 36
  • 29 (a)
ManyToMany
CG31413 36
  • 25 (a)
ManyToMany
CG4670 35
  • 46.57 (n)
  • 34.03 (a)
CG4670 36
  • 27 (a)
ManyToMany
CG6690 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F35G2.1 36
  • 22 (a)
ManyToMany
F47B7.2 36
  • 22 (a)
ManyToMany
T10H10.2 35
  • 43.01 (n)
  • 34.84 (a)
T10H10.2 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for QSOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QSOX1 Gene

ENSEMBL:
Gene Tree for QSOX1 (if available)
TreeFam:
Gene Tree for QSOX1 (if available)

Paralogs for QSOX1 Gene

Paralogs for QSOX1 Gene

Selected SIMAP similar genes for QSOX1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with QSOX1: view

Variants for QSOX1 Gene

Sequence variations from dbSNP and Humsavar for QSOX1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12371 - 180,194,255(+) CGTGC(A/G)CTACT reference, missense
rs1050154 -- 180,190,522(+) GTCCT(C/T)TTCCA reference, synonymous-codon
rs1148808 -- 180,177,634(-) CCACC(C/T)TCAGA intron-variant
rs1148809 -- 180,177,581(-) CCTTC(C/T)TAAAG intron-variant
rs1148810 -- 180,177,490(-) attgc(C/T)tgagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QSOX1 Gene

Variant ID Type Subtype PubMed ID
nsv832004 CNV Gain 17160897
nsv466239 CNV Gain 19166990
nsv872574 CNV Loss 21882294
nsv522045 CNV Loss 19592680
nsv528041 CNV Loss 19592680

Relevant External Links for QSOX1 Gene

HapMap Linkage Disequilibrium report
QSOX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QSOX1 Gene

Disorders for QSOX1 Gene

(2) Novoseek inferred disease relationships for QSOX1 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 26.8 1
tumors 0 1
genes like me logo Genes that share disorders with QSOX1: view

No data available for UniProtKB/Swiss-Prot for QSOX1 Gene

Publications for QSOX1 Gene

  1. The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. (PMID: 9878249) Coppock D.L. … Gilleran S. (Genomics 1998) 2 3 4 23
  2. Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases. (PMID: 10542195) Hoober K.L. … Thorpe C. (J. Biol. Chem. 1999) 3 4 23
  3. Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. (PMID: 10708601) Coppock D.L. … Cina-Poppe D.A. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  4. Preferential gene expression in quiescent human lung fibroblasts. (PMID: 8396966) Coppock D.L. … Gilleran S. (Cell Growth Differ. 1993) 2 3 23
  5. Identification and expression of a new splicing variant of FAD- sulfhydryl oxidase in adult rat brain. (PMID: 16806532) Radom J. … Jouvenot M. (Biochim. Biophys. Acta 2006) 3 4

Products for QSOX1 Gene

  • Addgene plasmids for QSOX1

Sources for QSOX1 Gene

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