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Aliases for QSOX1 Gene

Aliases for QSOX1 Gene

  • Quiescin Q6 Sulfhydryl Oxidase 1 2 3
  • Quiescin Q6 2 4
  • EC 4 64
  • QSCN6 3 4
  • HQSOX 3 4
  • Sulfhydryl Oxidase 1 3
  • Q6 3

External Ids for QSOX1 Gene

Previous Symbols for QSOX1 Gene

  • QSCN6

Summaries for QSOX1 Gene

Entrez Gene Summary for QSOX1 Gene

  • This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for QSOX1 Gene

QSOX1 (Quiescin Q6 Sulfhydryl Oxidase 1) is a Protein Coding gene. GO annotations related to this gene include protein disulfide isomerase activity and flavin-linked sulfhydryl oxidase activity. An important paralog of this gene is QSOX2.

UniProtKB/Swiss-Prot for QSOX1 Gene

  • Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.

Gene Wiki entry for QSOX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QSOX1 Gene

Genomics for QSOX1 Gene

Genomic Location for QSOX1 Gene

180,154,833 bp from pter
180,204,030 bp from pter
49,198 bases
Plus strand

Genomic View for QSOX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for QSOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QSOX1 Gene

Regulatory Elements for QSOX1 Gene

Proteins for QSOX1 Gene

  • Protein details for QSOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sulfhydryl oxidase 1
    Protein Accession:
    Secondary Accessions:
    • Q59G29
    • Q5T2X0
    • Q8TDL6
    • Q8WVP4

    Protein attributes for QSOX1 Gene

    747 amino acids
    Molecular mass:
    82578 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
    Quaternary structure:
    • Monomer.
    • Quiescin Q6 means that it was the sixth clone to be found at a higher level of expression in quiescent fibroblasts
    • Sequence=BAD92517.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for QSOX1 Gene

    Alternative splice isoforms for QSOX1 Gene


neXtProt entry for QSOX1 Gene

Proteomics data for QSOX1 Gene at MOPED

Selected DME Specific Peptides for QSOX1 Gene

Post-translational modifications for QSOX1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn130, Asn243, Thr276, Thr277, Thr281, Thr282, Thr289, Ser493, Ser549, Asn575, Ser576, Thr577, Ser588, Thr590, Thr592, Thr593, Ser604, Ser643, Thr647, and Ser655

Other Protein References for QSOX1 Gene

Domains for QSOX1 Gene


  • Contains 1 ERV/ALR sulfhydryl oxidase domain.:
    • O00391
  • Contains 1 thioredoxin domain.:
    • O00391
  • Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.:
    • O00391
genes like me logo Genes that share domains with QSOX1: view

No data available for Gene Families for QSOX1 Gene

Function for QSOX1 Gene

Molecular function for QSOX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2 RC(R)SH + O(2) = RC(R)S-S(R)CR + H(2)O(2).
UniProtKB/Swiss-Prot Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.
UniProtKB/Swiss-Prot Induction: Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycle and enter quiescence.

Enzyme Numbers (IUBMB) for QSOX1 Gene

Gene Ontology (GO) - Molecular Function for QSOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IGI 17331072
GO:0016971 flavin-linked sulfhydryl oxidase activity IGI 17331072
GO:0016972 thiol oxidase activity --
genes like me logo Genes that share ontologies with QSOX1: view
genes like me logo Genes that share phenotypes with QSOX1: view

miRNA for QSOX1 Gene

miRTarBase miRNAs that target QSOX1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for QSOX1 Gene

Localization for QSOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QSOX1 Gene

Isoform 1: Golgi apparatus membrane; Single-pass membrane protein.
Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells.

Subcellular locations from

Jensen Localization Image for QSOX1 Gene COMPARTMENTS Subcellular localization image for QSOX1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for QSOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 10708601
GO:0005794 Golgi apparatus IDA --
GO:0030173 integral component of Golgi membrane IDA 17331072
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with QSOX1: view

Pathways for QSOX1 Gene

SuperPathways for QSOX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for QSOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IGI 17331072
GO:0016242 negative regulation of macroautophagy IMP 24475161
GO:0045454 cell redox homeostasis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with QSOX1: view

No data available for Pathways by source for QSOX1 Gene

Compounds for QSOX1 Gene

(3) HMDB Compounds for QSOX1 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1H-Purin-6-amine flavin dinucleotide
  • Oxygen
  • Dihydrogen oxide
genes like me logo Genes that share compounds with QSOX1: view

Transcripts for QSOX1 Gene

Unigene Clusters for QSOX1 Gene

Quiescin Q6 sulfhydryl oxidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QSOX1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - - -
SP5: - -
SP6: - - -
SP7: -
SP9: -

Relevant External Links for QSOX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for QSOX1 Gene

mRNA expression in normal human tissues for QSOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for QSOX1 Gene

SOURCE GeneReport for Unigene cluster for QSOX1 Gene Hs.744925

mRNA Expression by UniProt/SwissProt for QSOX1 Gene

Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.
genes like me logo Genes that share expressions with QSOX1: view

Orthologs for QSOX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for QSOX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia QSOX1 36
  • 99.28 (n)
  • 98.5 (a)
QSOX1 37
  • 99 (a)
(Bos Taurus)
Mammalia QSOX1 36
  • 85.38 (n)
  • 80.11 (a)
QSOX1 37
  • 79 (a)
(Canis familiaris)
Mammalia QSOX1 37
  • 74 (a)
(Mus musculus)
Mammalia Qsox1 36
  • 78.59 (n)
  • 73.28 (a)
Qsox1 16
Qsox1 37
  • 71 (a)
(Monodelphis domestica)
Mammalia QSOX1 37
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia QSOX1 37
  • 54 (a)
(Rattus norvegicus)
Mammalia Qsox1 36
  • 79.18 (n)
  • 73.49 (a)
(Gallus gallus)
Aves QSOX1 36
  • 62.31 (n)
  • 54.63 (a)
QSOX1 37
  • 47 (a)
(Anolis carolinensis)
Reptilia QSOX1 37
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia qsox1 36
  • 51.78 (n)
  • 44.23 (a)
(Danio rerio)
Actinopterygii qsox1 36
  • 53.4 (n)
  • 45.55 (a)
qsox1 37
  • 38 (a)
sbcb840 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007491 36
  • 47.46 (n)
  • 35.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17843 37
  • 29 (a)
CG31413 37
  • 25 (a)
CG4670 36
  • 46.57 (n)
  • 34.03 (a)
CG4670 37
  • 27 (a)
CG6690 37
  • 25 (a)
(Caenorhabditis elegans)
Secernentea F35G2.1 37
  • 22 (a)
F47B7.2 37
  • 22 (a)
T10H10.2 36
  • 43.01 (n)
  • 34.84 (a)
T10H10.2 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
Species with no ortholog for QSOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QSOX1 Gene

Gene Tree for QSOX1 (if available)
Gene Tree for QSOX1 (if available)

Paralogs for QSOX1 Gene

Paralogs for QSOX1 Gene

Selected SIMAP similar genes for QSOX1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with QSOX1: view

Variants for QSOX1 Gene

Sequence variations from dbSNP and Humsavar for QSOX1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12371 - 180,194,255(+) CGTGC(A/G)CTACT reference, missense
rs1050154 -- 180,190,522(+) GTCCT(C/T)TTCCA reference, synonymous-codon
rs1148808 -- 180,177,634(-) CCACC(C/T)TCAGA intron-variant
rs1148809 -- 180,177,581(-) CCTTC(C/T)TAAAG intron-variant
rs1148810 -- 180,177,490(-) attgc(C/T)tgagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QSOX1 Gene

Variant ID Type Subtype PubMed ID
nsv832004 CNV Gain 17160897
nsv466239 CNV Gain 19166990
nsv872574 CNV Loss 21882294
nsv522045 CNV Loss 19592680
nsv528041 CNV Loss 19592680

Relevant External Links for QSOX1 Gene

HapMap Linkage Disequilibrium report

Disorders for QSOX1 Gene

(2) Novoseek inferred disease relationships for QSOX1 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 26.8 1
tumors 0 1
genes like me logo Genes that share disorders with QSOX1: view

No data available for UniProtKB/Swiss-Prot for QSOX1 Gene

Publications for QSOX1 Gene

  1. The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. (PMID: 9878249) Coppock D.L. … Gilleran S. (Genomics 1998) 2 3 4 23
  2. Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases. (PMID: 10542195) Hoober K.L. … Thorpe C. (J. Biol. Chem. 1999) 3 4 23
  3. Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. (PMID: 10708601) Coppock D.L. … Cina-Poppe D.A. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  4. Preferential gene expression in quiescent human lung fibroblasts. (PMID: 8396966) Coppock D.L. … Gilleran S. (Cell Growth Differ. 1993) 2 3 23
  5. Identification and expression of a new splicing variant of FAD- sulfhydryl oxidase in adult rat brain. (PMID: 16806532) Radom J. … Jouvenot M. (Biochim. Biophys. Acta 2006) 3 4

Products for QSOX1 Gene

Sources for QSOX1 Gene

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