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QSOX1 Gene

protein-coding   GIFtS: 54
GCID: GC01P180123

Quiescin Q6 Sulfhydryl Oxidase 1

(Previous name: quiescin Q6)
(Previous symbol: QSCN6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Quiescin Q6 Sulfhydryl Oxidase 11 2     EC 1.8.3.23 8
QSCN61 2 3     Q62
Quiescin Q61 3     Sulfhydryl Oxidase 12
hQSOX2 3     

External Ids:    HGNC: 97561   Entrez Gene: 57682   Ensembl: ENSG000001162607   OMIM: 6031205   UniProtKB: O003913   

Export aliases for QSOX1 gene to outside databases

Previous GC identifers: GC01P178391 GC01P151355


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for QSOX1 Gene:
This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene
families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter
quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants
encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for QSOX1 Gene:
QSOX1 (quiescin Q6 sulfhydryl oxidase 1) is a protein-coding gene. Diseases associated with QSOX1 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include protein disulfide isomerase activity and flavin-linked sulfhydryl oxidase activity. An important paralog of this gene is QSOX2.

UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391
Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the
reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted
proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation

Gene Wiki entry for QSOX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the QSOX1 gene promoter:
         Spz1   IRF-2   POU2F1   AML1a   POU2F1a   Cart-1   IRF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQSOX1 promoter sequence
   Search Chromatin IP Primers for QSOX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat QSOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q24

QSOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QSOX1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P180123:  view genomic region     (about GC identifiers)

Start:
180,123,968 bp from pter      End:
180,173,165 bp from pter
Size:
49,198 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391 (See protein sequence)
Recommended Name: Sulfhydryl oxidase 1 precursor  
Size: 747 amino acids; 82578 Da
Cofactor: Binds 1 FAD per subunit
Subunit: Monomer
Miscellaneous: 'Quiescin Q6' means that it was the sixth clone to be found at a higher level of expression in
quiescent fibroblasts
Sequence caution: Sequence=BAD92517.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for QSOX1:
3LLI (3D)        3LLK (3D)        3Q6O (3D)        4IJ3 (3D)    
Secondary accessions: Q59G29 Q5T2X0 Q8TDL6 Q8WVP4
Alternative splicing: 2 isoforms:  O00391-1   O00391-2   

Explore the universe of human proteins at neXtProt for QSOX1: NX_O00391

Explore proteomics data for QSOX1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn130, Asn243, Thr276, Thr277, Thr281, Thr282, Thr289, Ser493, Ser549, Asn575,
                                 Ser576, Thr577, Ser588, Thr590, Thr592, Thr593, Ser604, Ser643, Thr647, Ser655
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for QSOX1 (O00391) (see all 6)
     FPKVQWP  SWCGHCI  EDPQFPK  LFHFLTVQA 


    See QSOX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001004128.1  NP_002817.2  

    ENSEMBL proteins: 
     ENSP00000356574   ENSP00000375883   ENSP00000356572   ENSP00000402170  

    QSOX1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for QSOX1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017905 ERV/ALR_sulphydryl_oxidase
     IPR012336 Thioredoxin-like_fold
     IPR013766 Thioredoxin_domain

    Graphical View of Domain Structure for InterPro Entry O00391

    ProtoNet protein and cluster: O00391

    2 Blocks protein domains:
    IPB006662 Thioredoxin type domain
    IPB006863 Erv1/Alr


    UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391
    Similarity: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family
    Similarity: Contains 1 ERV/ALR sulfhydryl oxidase domain
    Similarity: Contains 1 thioredoxin domain


    QSOX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QSOX1_HUMAN, O00391
    Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the
    reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted
    proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation
    Catalytic activity: 2 R'C(R)SH + O(2) = R'C(R)S-S(R)CR' + H(2)O(2)
    Induction: Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycle and enter
    quiescence

         Enzyme Number (IUBMB): EC 1.8.3.21 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003756protein disulfide isomerase activity IGI17331072
    GO:0015035protein disulfide oxidoreductase activity ----
    GO:0016971flavin-linked sulfhydryl oxidase activity IGI17331072
    GO:0016972thiol oxidase activity ----
         
    QSOX1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for QSOX1:
     Decreased Salmonella enterica   Increased cell death in breast  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for QSOX1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for QSOX1
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    miRNA
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    miRTarBase miRNAs that target QSOX1:
    hsa-let-7e-5p (MIRT051544), hsa-mir-124-3p (MIRT022900)

    Block miRNA regulation of human, mouse, rat QSOX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate QSOX1 (see all 9):
    hsa-miR-495 hsa-miR-7-2* hsa-miR-4290 hsa-miR-3692 hsa-miR-124 hsa-miR-7-1* hsa-miR-506 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidQSOX1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for QSOX1
    Predesigned siRNA for gene silencing in human, mouse, rat QSOX1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): QSOX1 (NM_002826)
    Sino Biological Human cDNA Clone for QSOX1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for QSOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QSOX1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QSOX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    QSOX1_HUMAN, O00391: Isoform 1: Golgi apparatus membrane; Single-pass membrane protein
    QSOX1_HUMAN, O00391: Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of
    quiescent cells but is not found in proliferating cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA10708601
    GO:0030173integral component of Golgi membrane IDA17331072

    QSOX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for QSOX1
    Interactions:

        Search GeneGlobe Interaction Network for QSOX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for QSOX1 (O003912, 3 ENSP000003565744) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2862369 I2D: score=2 STRING: ENSP00000357292
    SCN2BENSP000002789474STRING: ENSP00000278947
    UBE2D2ENSP000003817174STRING: ENSP00000381717
    BEGAINENSP000003473014STRING: ENSP00000347301
    PRDX5ENSP000002654624STRING: ENSP00000265462
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IGI17331072
    GO:0006662glycerol ether metabolic process ----
    GO:0045454cell redox homeostasis IEA--
    GO:0055114oxidation-reduction process ----

    QSOX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for QSOX1

    3 HMDB Compounds for QSOX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for QSOX1 gene (2 alternative transcripts): 
    NM_001004128.2  NM_002826.4  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367602(uc001gny.3 uc001gnz.3) ENST00000392029 ENST00000367600
    ENST00000443059
    miRNA
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    Block miRNA regulation of human, mouse, rat QSOX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate QSOX1 (see all 9):
    hsa-miR-495 hsa-miR-7-2* hsa-miR-4290 hsa-miR-3692 hsa-miR-124 hsa-miR-7-1* hsa-miR-506 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidQSOX1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for QSOX1
    Predesigned siRNA for gene silencing in human, mouse, rat QSOX1
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    GenScript: all cDNA clones in your preferred vector (see all 2): QSOX1 (NM_002826)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for QSOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QSOX1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for QSOX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat QSOX1
      QuantiTect SYBR Green Assays in human, mouse, rat QSOX1
      QuantiFast Probe-based Assays in human, mouse, rat QSOX1

    Selected AceView cDNA sequences (see all 1123):

    BM771248 CF125412 CF125436 BM772993 NM_001004128 AI358823 BM561487 AI469130 
    AW241861 BU733310 AI910564 BQ920061 BQ878559 CB528946 BU628864 BQ953099 
    AA947617 CF125626 CF125424 BM771261 CF132176 CO247678 CF132132 CA390872 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for QSOX1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b
    SP1:              -                                                                                         -     -               
    SP2:              -                                                                                                               
    SP3:                          -                                                                                                   
    SP4:              -     -     -     -     -     -     -                                                                           
    SP5:        -     -                                                                                                               


    ECgene alternative splicing isoforms for QSOX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    QSOX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGATTCCC
    QSOX1 Expression
    About this image


    QSOX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Pancreas (Endocrine System)
     
     Ovary (Reproductive System)
     
     Esophagus (Gastrointestinal Tract)
    QSOX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    QSOX1 Protein Expression

    UniProtKB/Swiss-Prot: QSOX1_HUMAN, O00391
    Tissue specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain
    and kidney

        Custom PCR Arrays for QSOX1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QSOX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for QSOX1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Qsox11 , 5 quiescin Q6 sulfhydryl oxidase 11, 5 78.59(n)1
    73.28(a)1
      1 (67.64 cM)5
    1040091  NM_001024945.11  NP_001020116.11 
     1557781555 
    chicken
    (Gallus gallus)
    Aves QSOX11 quiescin Q6 sulfhydryl oxidase 1 62.31(n)
    54.63(a)
      373914  NM_204125.1  NP_989456.1 
    lizard
    (Anolis carolinensis)
    Reptilia QSOX16
    quiescin Q6 sulfhydryl oxidase 1
    42(a)
    1 ↔ 1
    4(70392296-70481159)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX720504.12   -- 78.47(n)    BX720504.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb8402 sbcb840 71.44(n)   378857  57048593 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46701 CG4670 46.57(n)
    34.03(a)
      36464  NM_137008.3  NP_610852.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T10H10.21 T10H10.2 43.01(n)
    34.84(a)
      180538  NM_076018.3  NP_508419.1 


    ENSEMBL Gene Tree for QSOX1 (if available)
    TreeFam Gene Tree for QSOX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for QSOX1 gene
    QSOX22  
    4 SIMAP similar genes for QSOX1 using alignment to 3 protein entries:     QSOX1_HUMAN (see all proteins):
    QSCN6    QSOX2    PDIA3    PDIA5

    QSOX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for QSOX1 (see all 1028)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1155096961,2
    C,F--180122086(+) CCTAAC/TCCAGA 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1124412271,2
    F--180122339(+) AGTGCC/TGCAAT 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs115895191,2
    C,F,A,H--180122390(+) CAAGGC/TCTATC 2 -- us2k19Minor allele frequency- T:0.48NA WA EA 370
    rs1509612191,2
    C--180122468(+) ATGTCC/GTTGTT 2 -- us2k10--------
    rs75301681,2
    C,F,A--180122575(+) AGCACT/CACATT 2 -- us2k17Minor allele frequency- C:0.20NA WA CSA EA 366
    rs75277331,2
    C,H--180122578(+) ACTACG/ATTCGA 2 -- us2k112Minor allele frequency- A:0.05NA WA CSA EA 256
    rs1406615601,2
    --180122579(+) CTACAC/TTCGAG 2 -- us2k10--------
    rs75162571,2
    C,F,A,H--180122812(+) cacctC/Tctctg 2 -- us2k117Minor allele frequency- T:0.12NS EA NA WA CSA 1968
    rs1154002091,2
    C,F--180122882(+) ATTTAC/GTTATG 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1851880771,2
    --180122967(+) TATACA/CTAAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for QSOX1 (180123968 - 180173165 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for QSOX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872574CNV Loss21882294
    nsv528041CNV Loss19592680
    nsv522045CNV Loss19592680
    nsv832004CNV Gain17160897
    nsv466239CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603120    OMIM disorders: --

    10 diseases for QSOX1:    
    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    insulin resistance    prostate cancer
    prostatitis    ataxia    endotheliitis    pancreatitis
    breast cancer    malaria


    QSOX1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for QSOX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 26.8 1 9878249 (1)
    tumors 0 1 19597465 (1)


    Export disorders for QSOX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for QSOX1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with QSOX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. (PubMed id 9878249)1, 2, 3, 9 Coppock D.L.... Gilleran S. (Genomics 1998)
    2. Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. (PubMed id 10708601)1, 2, 9 Coppock D.L.... Cina-Poppe D.A. (Biochem. Biophys. Res. Commun. 2000)
    3. Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases. (PubMed id 10542195)1, 2, 9 Hoober K.L.... Thorpe C. (J. Biol. Chem. 1999)
    4. Preferential gene expression in quiescent human lung fibroblasts. (PubMed id 8396966)1, 3, 9 Coppock D.L....Gilleran S. (amp 1993)
    5. QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains. (PubMed id 20211621)1, 2 Alon A.... Fass D. (FEBS Lett. 2010)
    6. Human quiescin-sulfhydryl oxidase, QSOX1: probing internal redox steps by mutagenesis. (PubMed id 18393449)1, 2 Heckler E.J.... Thorpe C. (Biochemistry 2008)
    7. Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1. (PubMed id 17331072)1, 2 Chakravarthi S.... Bulleid N.J. (Biochem. J. 2007)
    8. Identification and expression of a new splicing variant of FAD- sulfhydryl oxidase in adult rat brain. (PubMed id 16806532)1, 2 Radom J.... Jouvenot M. (Biochim. Biophys. Acta 2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5768 HGNC: 9756 AceView: QSCN6 Ensembl:ENSG00000116260 euGenes: HUgn5768
    ECgene: QSOX1 H-InvDB: QSOX1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for QSOX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for QSOX1 gene:
    Search GeneIP for patents involving QSOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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