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Aliases for QSER1 Gene

Aliases for QSER1 Gene

  • Glutamine And Serine Rich 1 2 3 5

External Ids for QSER1 Gene

Previous GeneCards Identifiers for QSER1 Gene

  • GC11P032609

Summaries for QSER1 Gene

GeneCards Summary for QSER1 Gene

QSER1 (Glutamine And Serine Rich 1) is a Protein Coding gene. An important paralog of this gene is PRR12.

Additional gene information for QSER1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QSER1 Gene

Genomics for QSER1 Gene

Regulatory Elements for QSER1 Gene

Enhancers for QSER1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H033475 0.8 ENCODE 36.6 +583.1 583113 0 NFIB ZNF195 FEZF1 ZNF2 ZNF121 ZNF776 LCORL ZNF350 PRDM10 NFIA QSER1 HNRNPA3P9 NAT10 FBXO3 CSTF3 CAPRIN1 KIAA1549L ENSG00000255207 GC11P033533
GH11H032890 1.4 ENCODE dbSUPER 20.5 +0.3 278 4 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B CBX5 ZNF207 ZNF143 QSER1 HNRNPA3P9 CSTF3 CCDC73 PIR46589
GH11H033265 1.4 Ensembl ENCODE dbSUPER 15.5 +373.4 373423 1 FOXA2 FEZF1 BMI1 ZNF202 ZNF362 ZHX2 CEBPB ZNF843 NFIL3 PRDM6 NAT10 QSER1 EIF3M CAPRIN1 HIPK3 KIAA1549L
GH11H032087 1.4 FANTOM5 Ensembl ENCODE 14.3 -804.9 -804948 2 PKNOX1 NFIB FEZF1 ZNF2 RFX5 ZNF366 RCOR1 FOS RUNX3 IKZF2 RCN1 QSER1 EIF4A2P5 ENSG00000255252
GH11H033159 1.1 ENCODE 15.5 +268.1 268139 3 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 NAT10 EIF3M QSER1 HIPK3 CAPRIN1 CSTF3 TCP11L1 PIGCP1 DEPDC7 CSTF3-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around QSER1 on UCSC Golden Path with GeneCards custom track

Promoters for QSER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000038481 122 3001 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B CBX5 ZNF143 ZNF207

Genomic Location for QSER1 Gene

Chromosome:
11
Start:
32,893,178 bp from pter
End:
32,993,316 bp from pter
Size:
100,139 bases
Orientation:
Plus strand

Genomic View for QSER1 Gene

Genes around QSER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QSER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QSER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QSER1 Gene

Proteins for QSER1 Gene

  • Protein details for QSER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2KHR3-QSER1_HUMAN
    Recommended name:
    Glutamine and serine-rich protein 1
    Protein Accession:
    Q2KHR3
    Secondary Accessions:
    • Q6ZU30
    • Q6ZUR5

    Protein attributes for QSER1 Gene

    Size:
    1735 amino acids
    Molecular mass:
    189972 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI12936.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC86397.1; Type=Erroneous termination; Positions=1555; Note=Translated as Leu.; Evidence={ECO:0000305};

    Alternative splice isoforms for QSER1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QSER1 Gene

Post-translational modifications for QSER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for QSER1 Gene

Domains & Families for QSER1 Gene

Gene Families for QSER1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for QSER1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for QSER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with QSER1: view

No data available for UniProtKB/Swiss-Prot for QSER1 Gene

Function for QSER1 Gene

Phenotypes From GWAS Catalog for QSER1 Gene

Phenotypes for QSER1 Gene

genes like me logo Genes that share phenotypes with QSER1: view

Animal Model Products

CRISPR Products

miRNA for QSER1 Gene

miRTarBase miRNAs that target QSER1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for QSER1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QSER1 Gene

Localization for QSER1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QSER1 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for QSER1 Gene

Pathways & Interactions for QSER1 Gene

SuperPathways for QSER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for QSER1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for QSER1 Gene

Drugs & Compounds for QSER1 Gene

No Compound Related Data Available

Transcripts for QSER1 Gene

Unigene Clusters for QSER1 Gene

Glutamine and serine rich 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for QSER1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for QSER1 Gene

No ASD Table

Relevant External Links for QSER1 Gene

GeneLoc Exon Structure for
QSER1
ECgene alternative splicing isoforms for
QSER1

Expression for QSER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QSER1 Gene

Protein differential expression in normal tissues from HIPED for QSER1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for QSER1 Gene



Protein tissue co-expression partners for QSER1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of QSER1 Gene:

QSER1

SOURCE GeneReport for Unigene cluster for QSER1 Gene:

Hs.369368

Evidence on tissue expression from TISSUES for QSER1 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with QSER1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QSER1 Gene

Orthologs for QSER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for QSER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QSER1 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia QSER1 33 34
  • 92.41 (n)
cow
(Bos Taurus)
Mammalia QSER1 33 34
  • 91.29 (n)
mouse
(Mus musculus)
Mammalia Qser1 33 16 34
  • 86.08 (n)
rat
(Rattus norvegicus)
Mammalia Qser1 33
  • 85.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia QSER1 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia QSER1 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves QSER1 33 34
  • 75.69 (n)
lizard
(Anolis carolinensis)
Reptilia QSER1 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100036640 33
  • 66.69 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2293 33
zebrafish
(Danio rerio)
Actinopterygii LOC100330496 33
  • 60.8 (n)
qser1 34
  • 42 (a)
OneToOne
Species where no ortholog for QSER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for QSER1 Gene

ENSEMBL:
Gene Tree for QSER1 (if available)
TreeFam:
Gene Tree for QSER1 (if available)

Paralogs for QSER1 Gene

Paralogs for QSER1 Gene

genes like me logo Genes that share paralogs with QSER1: view

Variants for QSER1 Gene

Sequence variations from dbSNP and Humsavar for QSER1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000016202 -- 32,946,152(+) CTTCA(A/T)AGTTT intron-variant
rs1000034043 -- 32,901,133(+) TCTTA(A/G)ACAAG intron-variant
rs1000083457 -- 32,896,002(+) TACTT(C/G)GAAAG intron-variant
rs1000115603 -- 32,972,394(+) CATAA(A/G)TAGGC intron-variant
rs1000172765 -- 32,927,469(+) GTGGC(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QSER1 Gene

Variant ID Type Subtype PubMed ID
esv2759815 CNV gain 17122850
esv2762904 CNV gain 21179565
esv34742 CNV gain 17911159
esv3579466 CNV loss 25503493
nsv1040484 CNV gain 25217958
nsv1113375 CNV deletion 24896259
nsv38614 CNV deletion 16902084

Variation tolerance for QSER1 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for QSER1 Gene

Human Gene Mutation Database (HGMD)
QSER1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
QSER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QSER1 Gene

Disorders for QSER1 Gene

Relevant External Links for QSER1

Genetic Association Database (GAD)
QSER1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QSER1

No disorders were found for QSER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QSER1 Gene

Publications for QSER1 Gene

  1. Genomewide association study for onset age in Parkinson disease. (PMID: 19772629) Latourelle JC … GenePD Investigators, Coordinators and Molecular Genetic Laboratories (BMC medical genetics 2009) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier RA … Vermeulen M (The Journal of biological chemistry 2016) 3 60

Products for QSER1 Gene

Sources for QSER1 Gene

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