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Aliases for QSER1 Gene

Aliases for QSER1 Gene

  • Glutamine And Serine Rich 1 2 3 5

External Ids for QSER1 Gene

Previous GeneCards Identifiers for QSER1 Gene

  • GC11P032609

Summaries for QSER1 Gene

GeneCards Summary for QSER1 Gene

QSER1 (Glutamine And Serine Rich 1) is a Protein Coding gene. An important paralog of this gene is PRR12.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QSER1 Gene

Genomics for QSER1 Gene

Regulatory Elements for QSER1 Gene

Enhancers for QSER1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G032890 1.4 ENCODE dbSUPER 8.4 +0.3 278 4.9 PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B EIF3M FBXO3 CCDC73 QSER1 PIR46589
GH11G032851 0.9 Ensembl ENCODE 11.6 -40.8 -40801 1.0 GATAD2A SOX5 SOX13 FOXA2 NFIA BHLHE40 FOXA3 CEBPB ZMYM3 KDM1A PRRG4 QSER1 TCP11L1 CCDC73
GH11G032839 0.7 ENCODE 11.8 -54.4 -54429 0.2 JUN CEBPG HIC1 ZFHX2 ZNF366 FOS PRDM10 EGR2 ZNF10 GFI1B QSER1 TCP11L1 PRRG4
GH11G032838 0.7 ENCODE 11.8 -54.2 -54169 0.2 ZFP37 CEBPB ZNF501 CEBPG EP300 IRF9 HIC1 ZNF664 PRDM6 GATA3 QSER1 TCP11L1 PRRG4
GH11G032432 1.3 ENCODE dbSUPER 4.1 -458.7 -458681 4.7 HDGF PKNOX1 CREB3L1 AGO1 SIN3A ZNF766 KLF13 ZNF263 SP3 REST QSER1 WT1-AS THEM7P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around QSER1 on UCSC Golden Path with GeneCards custom track

Promoters for QSER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000038481 122 3001 PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B

Genomic Location for QSER1 Gene

Chromosome:
11
Start:
32,893,178 bp from pter
End:
32,993,316 bp from pter
Size:
100,139 bases
Orientation:
Plus strand

Genomic View for QSER1 Gene

Genes around QSER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QSER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QSER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QSER1 Gene

Proteins for QSER1 Gene

  • Protein details for QSER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2KHR3-QSER1_HUMAN
    Recommended name:
    Glutamine and serine-rich protein 1
    Protein Accession:
    Q2KHR3
    Secondary Accessions:
    • Q6ZU30
    • Q6ZUR5

    Protein attributes for QSER1 Gene

    Size:
    1735 amino acids
    Molecular mass:
    189972 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI12936.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC86397.1; Type=Erroneous termination; Positions=1555; Note=Translated as Leu.; Evidence={ECO:0000305};

    Alternative splice isoforms for QSER1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QSER1 Gene

Post-translational modifications for QSER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for QSER1 Gene

Domains & Families for QSER1 Gene

Protein Domains for QSER1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for QSER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with QSER1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for QSER1 Gene

Function for QSER1 Gene

Phenotypes for QSER1 Gene

genes like me logo Genes that share phenotypes with QSER1: view

Animal Model Products

CRISPR Products

miRNA for QSER1 Gene

miRTarBase miRNAs that target QSER1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QSER1 Gene

Localization for QSER1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QSER1 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for QSER1 Gene

Pathways & Interactions for QSER1 Gene

SuperPathways for QSER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for QSER1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for QSER1 Gene

Transcripts for QSER1 Gene

Unigene Clusters for QSER1 Gene

Glutamine and serine rich 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for QSER1 Gene

No ASD Table

Relevant External Links for QSER1 Gene

GeneLoc Exon Structure for
QSER1
ECgene alternative splicing isoforms for
QSER1

Expression for QSER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QSER1 Gene

Protein differential expression in normal tissues from HIPED for QSER1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for QSER1 Gene



Protein tissue co-expression partners for QSER1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of QSER1 Gene:

QSER1

SOURCE GeneReport for Unigene cluster for QSER1 Gene:

Hs.369368

Evidence on tissue expression from TISSUES for QSER1 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with QSER1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QSER1 Gene

Orthologs for QSER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for QSER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QSER1 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia QSER1 34 35
  • 92.41 (n)
cow
(Bos Taurus)
Mammalia QSER1 34 35
  • 91.29 (n)
mouse
(Mus musculus)
Mammalia Qser1 34 16 35
  • 86.08 (n)
rat
(Rattus norvegicus)
Mammalia Qser1 34
  • 85.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia QSER1 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia QSER1 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves QSER1 34 35
  • 75.69 (n)
lizard
(Anolis carolinensis)
Reptilia QSER1 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100036640 34
  • 66.69 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2293 34
zebrafish
(Danio rerio)
Actinopterygii LOC100330496 34
  • 60.8 (n)
qser1 35
  • 42 (a)
OneToOne
Species where no ortholog for QSER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for QSER1 Gene

ENSEMBL:
Gene Tree for QSER1 (if available)
TreeFam:
Gene Tree for QSER1 (if available)

Paralogs for QSER1 Gene

Paralogs for QSER1 Gene

genes like me logo Genes that share paralogs with QSER1: view

Variants for QSER1 Gene

Sequence variations from dbSNP and Humsavar for QSER1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000016202 -- 32,946,152(+) CTTCA(A/T)AGTTT intron-variant
rs1000034043 -- 32,901,133(+) TCTTA(A/G)ACAAG intron-variant
rs1000083457 -- 32,896,002(+) TACTT(C/G)GAAAG intron-variant
rs1000115603 -- 32,972,394(+) CATAA(A/G)TAGGC intron-variant
rs1000172765 -- 32,927,469(+) GTGGC(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QSER1 Gene

Variant ID Type Subtype PubMed ID
esv2759815 CNV gain 17122850
esv2762904 CNV gain 21179565
esv34742 CNV gain 17911159
esv3579466 CNV loss 25503493
nsv1040484 CNV gain 25217958
nsv1113375 CNV deletion 24896259
nsv38614 CNV deletion 16902084

Variation tolerance for QSER1 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for QSER1 Gene

Human Gene Mutation Database (HGMD)
QSER1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
QSER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QSER1 Gene

Disorders for QSER1 Gene

Relevant External Links for QSER1

Genetic Association Database (GAD)
QSER1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QSER1

No disorders were found for QSER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QSER1 Gene

Publications for QSER1 Gene

  1. Genomewide association study for onset age in Parkinson disease. (PMID: 19772629) Latourelle J.C. … . (BMC Med. Genet. 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier R.A. … Vermeulen M. (J. Biol. Chem. 2016) 3 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for QSER1 Gene

Sources for QSER1 Gene

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