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QSER1 Gene

protein-coding GIFtS: 38

GC11P032905

glutamine and serine rich 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ21924 ^¹, ²

Descriptions
glutamine and serine rich 1 ^²

External Ids
HGNC: 26154¹
Entrez Gene: 79832²
UniProtKB: Q2KHR3³
Ensembl: ENSG00000060749⁷

Search outside databases for aliases for QSER1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the QSER1 gene

Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13

QSER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P032905: (about GC identifiers)

Start:	32,871,368 bp from pter
End:	32,958,392 bp from pter
Size:	87,025 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: QSER1_HUMAN, Q2KHR3 (See protein sequence)

Recommended Name: Glutamine and serine-rich protein 1

Size: 1735 amino acids; 189945 Da

Secondary accessions: Q6ZU30 Q6ZUR5

Alternative splicing: 2 isoforms: Q2KHR3-1 Q2KHR3-2

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001070254.1

ENSEMBL proteins:

ENSP00000078652 ENSP00000382241

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for QSER1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for QSER1
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for QSER1

Assays for QSER1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q2KHR3

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QSER1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001076786

Applied Biosystems Silencer® siRNAs for QSER1

Sigma-Aldrich siRNA for QSER1

Sigma-Aldrich shRNA for QSER1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001076786
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001076786
untagged cDNA clone in CMV expression vector: NM_001076786

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001076786

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for QSER1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QSER1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001076786

Sigma-Aldrich siRNA for QSER1

Sigma-Aldrich shRNA for QSER1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001076786

REFSEQ mRNAs for QSER1 gene:

NM_001076786.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001076786

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001076786
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001076786
                                 untagged cDNA clone in CMV expression vector: NM_001076786

Additional cDNA sequence:

AK025577.1 AK055185.1 AK095528.1 AK123858.1 AK125391.1 AK125902.1 AK126023.1 AL834141.1

BC013746.1 BC112935.1

6 DOTS entries:

DT.97770969 DT.101982980 DT.438703 DT.100734925 DT.100845821 DT.120705306

24/163 AceView cDNA sequences (see all 163 ):

AW469421 AI149869 BE673053 AK126023 BM479174 BQ188562 AA136884 AW439344

AI061251 AI369449 BM452320 AI076404 AI025951 BQ271716 AW090520 AA905517

BU194044 CA430191 AA749230 AW769001 AI094105 CA449218 AI381640 BM670701

highest scoring ESTs for QSER1:

AA905517 AI075772 AK126023 N78362 AA053856 AA127281 AA136958 AA249363 AA280025 AA280094

Unigene Cluster for QSER1:

Glutamine and serine rich 1

Hs.369368 [show with all ESTs]

Unigene Representative Sequence: NM_001076786

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000078652 ENST00000399302

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

QSER1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for QSER1

¹ / ² / ³

13 probe-sets matching QSER1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65546_at²^{, 3}	U95-C	1	1.00	1.00	0.26	1.49	N78362	0.80	1.00	0.91	1
79485_at²^{, 3}	U95-D	1	1.00	1.00	0.61	0.72	AA905517	0.80	1.00	0.91	1
68825_at²^{, 3}	U95-E	1	1.00	1.00	0.11	1.06	AA053856	0.60	1.00	0.82	1
88247_at²^{, 3}	U95-D	1	1.00	1.00	0.39	1.26	AI075772	0.80	1.00	0.91	1
49134_at²^{, 3}	U95-B	1	1.00	1.00	0.74	0.60	AA642350	0.60	1.00	0.82	1
226265_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW294894	0.60	1.00	0.82	1
244563_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BG026723	0.60	1.00	0.82	1
219705_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024774	0.40	1.00	0.76	1
229982_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW195525	0.40	1.00	0.76	1
226265_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
244563_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219705_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229982_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTTAGCAAA

SOURCE GeneReport for Unigene cluster: Hs.369368

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for QSER1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	QSER1¹	--	glutamine and serine rich 1	92.41(n) 91.73(a)	483436 XM_540554.2 XP_540554.2
chimpanzee (Pan troglodytes)	QSER1¹	--	glutamine and serine rich 1	94.71(n) 93.87(a)	451107 XM_508354.2 XP_508354.2
cow (Bos taurus)	QSER1¹	--	glutamine and serine rich 1	90.91(n) 88.58(a)	508553 XM_865223.2 XP_870316.2
rat (Rattus norvegicus)	Qser1¹	--	glutamine and serine rich 1	76.35(n) 70.48(a)	311266 XM_230348.4 XP_230348.4
mouse (Mus musculus)	Qser1^{1, 5}	2⁵	glutamine and serine rich 1^{1, 5}	84.67(n)¹ 80.02(a)¹	99003¹ XM_001479246.1¹ XP_001479296.1¹ AI502974⁵ AI549907⁵ (see all 11)

About this table Species with no ortholog for QSER1

ENSEMBL Gene Tree for QSER1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for QSER1 gene

PRR12²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/252 NCBI SNPs in QSER1 are shown (see all 252 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 50)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1022586^1,2	A,C,F,H,O	32910920(-)	`AGTTAT/CAGTCT`	1	I/V	mis¹		9		MN EU EA WA NA	834
	rs2297781^1,2	C,F,H,O	32911698(+)	`TAACCA/GACAAA`	1	Q/R	mis¹		11		NA EU EA WA	980
	rs16923676^1,2	C,F,H	32932098(+)	`CAGTAA/GATATT`	1	N/D	mis¹		11		NA EU EA WA	968
	rs7940077^1,2	C,F,H	32912820(+)	`AGAGAG/ATGCTA`	1	S/N	mis¹ ese³		12		MN EU EA WA NA	1166
	rs4756402^1,2	H	32957666(+)	`ATTACA/CCTATC`	1	--	ut3¹		4		EU EA WA	416
--	rs2786801^1,2	C	32871367(-)	`TCGTAC/GGCCCA`	1	--	ng5¹		0	--	--	--	--
	rs12289337^1,2	H	32957245(+)	`cttacG/Aggacc`	1	--	ut3¹		4		EU EA WA	418
	rs12792969^1,2	F	32958599(+)	`AACAAT/CGGCAG`	1	--	ng3¹		1		NA	92
	rs7481878^1,2	A,C,F,H	32913196(+)	`CAACCG/AGAAGT`	1	P/P	syn¹ ese³		7		EU EA WA NA	560
	rs12293579^1,2	C,F,H	32947256(+)	`GATCAA/GTCATT`	1	Q/Q	syn¹		8		EU EA WA	838

About this table

HapMap Linkage Disequilibrium images for QSER1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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8 PubMed articles for QSER1 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)⁴ Matsuoka S.... Elledge S.J. (2007)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS Spectra. (PubMed id 17924679)⁴ Yu L.-R.... Veenstra T.D. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)⁴ Olsen J.V....Mann M. (2006)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)⁴ Taylor T.D....Sakaki Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79832	HGNC: 26154	AceView: FLJ21924	Ensembl:ENSG00000060749	euGenes: HUgn79832
ECgene: QSER1	H-InvDB: QSER1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for QSER1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for QSER1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for QSER1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for QSER1		Antibodies for QSER1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for QSER1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for QSER1

Search Tocris compounds for QSER1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for QSER1

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QSER1 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for QSER1

Summaries
for QSER1

Genomic Location
for QSER1

Proteins
for QSER1

Protein Domains/
Families
for QSER1

Gene Function
for QSER1

Pathways & Interactions
for QSER1

Drugs & Compounds
for QSER1

Transcripts
for QSER1

Expression
for QSER1

Orthologs
for QSER1

Paralogs
for QSER1

SNPs/Variants
for QSER1

Disorders & Mutations
for QSER1

Medical News
for QSER1

Publications
for QSER1

Search for QSER1

Genome Databases showing QSER1

Other Databases showing QSER1

Specialized Databases showing QSER1

Licensable Technologies
for QSER1

Services
for QSER1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

QSER1 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor QSER1

Summariesfor QSER1

Genomic Locationfor QSER1

Proteinsfor QSER1

Protein Domains/Familiesfor QSER1

Gene Functionfor QSER1

Pathways & Interactionsfor QSER1

Drugs & Compoundsfor QSER1

Transcriptsfor QSER1

Expression for QSER1

Orthologsfor QSER1

Paralogsfor QSER1

SNPs/Variantsfor QSER1

Disorders & Mutationsfor QSER1

Medical Newsfor QSER1

Publicationsfor QSER1

Search for QSER1

Genome Databases showing QSER1

Other Databases showing QSER1

Specialized Databases showing QSER1

Licensable Technologiesfor QSER1

Servicesfor QSER1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for QSER1

Summaries
for QSER1

Genomic Location
for QSER1

Proteins
for QSER1

Protein Domains/
Families
for QSER1

Gene Function
for QSER1

Pathways & Interactions
for QSER1

Drugs & Compounds
for QSER1

Transcripts
for QSER1

Expression
for QSER1

Orthologs
for QSER1

Paralogs
for QSER1

SNPs/Variants
for QSER1

Disorders & Mutations
for QSER1

Medical News
for QSER1

Publications
for QSER1

Licensable Technologies
for QSER1

Services
for QSER1