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QRSL1 Gene

protein-coding   GIFtS: 54

GC06P107185
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZP564C1278 1
DKFZp564C1278 2
EC 6.3.5.- 3
FLJ10989 1, 2
FLJ12189 1, 2
FLJ13447 1, 2
GatA 1, 2
OTTHUMP00000016923 2
Descriptions
Glutaminyl-tRNA synthase-like protein 1 3
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2
External Ids
HGNC: 210201
Entrez Gene: 552782
UniProtKB: Q9H0R63
Ensembl: ENSG000001303487
Search outside databases for aliases for QRSL1 gene

Previous GC identifers: GC06P107077 GC06P107123

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the QRSL1 gene  

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

QRSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P107185:     (about GC identifiers)

Start:
107,184,146 bp from pter
End:
107,222,103 bp from pter
Size:
37,958 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000006.10  NT_025741.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: QRSL1_HUMAN, Q9H0R6 (See protein sequence)
Recommended Name: Glutamyl-tRNA(Gln) amidotransferase subunit A homolog  
Size: 528 amino acids; 57460 Da
Sequence caution: Sequence=CAH72094.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5VWJ4 Q9HA60 Q9NV19
Alternative splicing: 2 isoforms:  Q9H0R6-1   Q9H0R6-2   

REFSEQ proteins: NP_060762.3  

ENSEMBL proteins: 
ENSP00000358042 ENSP00000358040 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (QRSL)
Human Recombinant Proteins from Abnova (QRSL1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for QRSL1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (QRSL), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (QRSL1)
Novus Biologicals Antibodies for QRSL1

Assays for QRSL1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR000120 Amidase_sig_enz
 IPR004412 GatA


   GeneDecks  QRSL1 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9H0R6

ProtoNet protein and cluster: Q9H0R6

1 Blocks protein family: IPB000120 Amidase

UniProtKB/Swiss-Prot: QRSL1_HUMAN, Q9H0R6
Similarity: Belongs to the amidase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (QRSL1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018292

              Applied Biosystems Silencer® siRNAs for QRSL1

              Sigma-Aldrich siRNA for QRSL1  
                     Sigma-Aldrich shRNA for QRSL1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for QRSL1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018292
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018292
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_018292 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_018292

UniProtKB/Swiss-Prot: QRSL1_HUMAN, Q9H0R6
Catalytic activity: ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate +
L-glutaminyl-tRNA(Gln) + L-glutamate
Enzyme Number (IUBMB): EC 6.3.5.- 

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016874 ligase activity IEA--
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA--
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Interacting proteins for QRSL1 (ENSP000003580423) via UniProtKB, MINT, and/or STRING (see all 7 )
InteractantInteraction Details
GeneCardExternal ID(s)
PET112LENSP000002639853STRING (score=.967)
GATA2ENSP000003456813STRING (score=.746)
GATA1ENSP000003658583STRING (score=.74)
GATA4ENSP000003344583STRING (score=.718)
SUCLG1ENSP000002957833STRING (score=.714)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006412 translation IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for QRSL1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (QRSL1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018292

              Sigma-Aldrich siRNA for QRSL1  
                     Sigma-Aldrich shRNA for QRSL1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_018292  

REFSEQ mRNAs for QRSL1 gene: 

NM_018292.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_018292  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018292
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018292
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_018292 

Additional cDNA sequence: 

AK001851.1 AK022251.1 AK023509.1 AK055349.1 AK225262.1 AK225443.1 AK314694.1 AL136679.1 
BC006084.1 BC014389.2 CR592831.1 CR598150.1 CR618052.1 

11 DOTS entries:

DT.443382  DT.100792867  DT.100670980  DT.95278114  DT.95278116  DT.95319561  DT.100717177  DT.100023319 
DT.100806027  DT.91755953  DT.95278113 

24/174 AceView cDNA sequences (see all 174 ):

AA602557 BG185173 AW006165 BX099642 AW337453 AK023509 N66117 AI564684 
BG194540 BM802270 BE326616 AA961015 R94566 AK022251 BC014389 CR598150 
AW612708 AU121726 BU619644 BC006084 CB161672 BM556530 BE891356 AK001851 

highest scoring ESTs for QRSL1:

AI416985 AI861854 AK001851 AK023509 AL136679 AU156313 AW976132 BC006084 BC014389 BG036566 

Unigene Cluster for QRSL1:

Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Hs.406917  [show with all ESTs]
Unigene Representative Sequence: NM_018292


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for QRSL1

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1:                    -                 -                                                         
SP2:                                                                    -                           
SP3:                                      -                                                         
SP4:                    -                                                                           

About this scheme

ECgene alternative splicing isoforms for QRSL1

2 Ensembl transcripts including schematic representations:
ENST00000369046  ENST00000369044  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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QRSL1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for QRSL1

1 / 2 / 3

12 probe-sets matching QRSL1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

42742_at2, 3 U95-B 1 1.00 1.00 0.78 0.93 AA769438 0.60 1.00 0.82 1

62794_at2, 3 U95-C 1 1.00 1.00 0.46 1.29 AI861854 0.80 1.00 0.91 1
90930_at2, 3 U95-E 3 1.00 0.64 0.89 1.09 AI416985 1.00 1.00 1.00 1

78338_at2, 3 U95-E 1 0.81 1.00 0.19 0.71 R01445 0.40 1.00 0.76 1

241933_at2, 3 U133-B 1 1.00 1.00 -- -- AA769438 0.60 1.00 0.82 1

218948_at2, 3 U133-A 1 1.00 1.00 -- -- AL136679 0.80 1.00 0.91 1

233089_at2, 3 U133-B 1 1.00 1.00 -- -- AK022251 0.60 1.00 0.82 1

218949_s_at2, 3 U133-A 3 1.00 0.74 -- -- NM_018292 0.60 1.00 0.82 1

241933_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

218948_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

233089_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

218949_s_at2 U133Plus2 3 1.00 0.74 -- -- -- -- -- -- --
GeneDecks  QRSL1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AGAGAAAATT

SOURCE GeneReport for Unigene cluster: Hs.406917
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for QRSL1 gene from 5/20 species (see all 20 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
QRSL11   -- glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like more 91.13(n)
92.42(a)
475014  XM_532250.2  XP_532250.2 
chimpanzee
(Pan troglodytes)
QRSL11   -- glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like more 99.37(n)
99.43(a)
462909  XM_518663.2  XP_518663.2 
cow
(Bos taurus)
QRSL11   -- glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like more 89.61(n)
92.78(a)
532822  NM_001046336.1  NP_001039801.1 
rat
(Rattus norvegicus)
Qrsl11   -- glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like more 83.65(n)
87.21(a)
309911  NM_001014034.1  NP_001014056.1 
mouse
(Mus musculus)
Qrsl11, 5 105
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like more1, 5 84.8(n)1
88.17(a)1
765631  NM_001081054.11  NP_001074523.11 
 AK0123515  AK0388015  (see all 12)
About this table        Species with no ortholog for QRSL1

ENSEMBL Gene Tree for QRSL1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for QRSL1 gene
FAAH2  FAAH22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/258 NCBI SNPs in QRSL1 are shown (see all 258 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 101)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs10266191,2
A,C,F,H,O107221054(-) CTTACT/CAAATG 1 -- ut3121Minor allele frequency- C:0.25NS MN EU EA WA NA 1678
rs31014931,2
A,C,F,H107222087(-) GAATTT/CATTAA 1 -- ut317Minor allele frequency- C:0.22NA EU EA WA 526
rs170676141,2
F,H107222077(+) GAATTG/TTTACT 1 -- ut317Minor allele frequency- T:0.07NA EU EA WA 556
rs360168981,2
C,F107194924(-) GTGCCG/ACAGAA 1 V/A mis15Minor allele frequency- A:0.02NA EU EA WA 498
rs342219171,2
C,F107207089(-) GTTTAT/CTAATA 1 S/N mis15Minor allele frequency- C:0.04NA EU EA WA 492
rs170676131,2
F,H107221918(+) TCTGTA/CTTCAA 1 -- ut317Minor allele frequency- C:0.07NA EU EA WA 560
--
rs21694631,2
A,C107220646(-) CCTTGC/GCCTCC 1 -- ut310--------
rs125257831,2
H107221659(+) GTAACC/TTAACA 1 -- ut314Minor allele frequency- T:0.00EU EA WA 420
--
rs93738891,2
A107220656(+) GCGAGC/TGGATC 1 -- ut31 ese30--------
--
rs94000451,2
A107220660(+) GCGGAA/TCATGA 1 -- ut31 ese30--------
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HapMap Linkage Disequilibrium images for QRSL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: QRSL1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/13 PubMed articles for QRSL1 gene (see all 13 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55278 HGNC: 21020 AceView: QRSL1 Ensembl:ENSG00000130348 euGenes: HUgn55278
ECgene: QRSL1 H-InvDB: QRSL1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for QRSL1 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for QRSL1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for QRSL1-related products

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 Millipore Preclinical / Clinical Development Services
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 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for QRSL1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for QRSL1 Browse small molecules at Sigma-Aldrich
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 Antibodies for QRSL1

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