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Aliases for QRSL1 Gene

Aliases for QRSL1 Gene

  • Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 1 2 3
  • Glutaminyl-TRNA Synthase-Like Protein 1 3 4
  • Glu-AdT Subunit A 3 4
  • Glutamyl-TRNA(Gln) Amidotransferase Subunit A, Mitochondrial 3
  • Glutamyl-TRNA(Gln) Amidotransferase Subunit A Homolog 3
  • Glutamyl-TRNA(Gln) Amidotransferase, Subunit A 3
  • Glutamyl-TRNA(Gln) Amidotransferase 2
  • EC 6.3.5.7 4
  • Subunit A 2
  • GatA 3

External Ids for QRSL1 Gene

Summaries for QRSL1 Gene

GeneCards Summary for QRSL1 Gene

QRSL1 (Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 1) is a Protein Coding gene. Diseases associated with QRSL1 include lymphogranuloma venereum. Among its related pathways are Metabolism and tRNA Aminoacylation. GO annotations related to this gene include glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity.

UniProtKB/Swiss-Prot for QRSL1 Gene

  • Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRSL1 Gene

Genomics for QRSL1 Gene

Genomic Location for QRSL1 Gene

Start:
106,629,566 bp from pter
End:
106,668,417 bp from pter
Size:
38,852 bases
Orientation:
Plus strand

Genomic View for QRSL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for QRSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRSL1 Gene

Regulatory Elements for QRSL1 Gene

Proteins for QRSL1 Gene

  • Protein details for QRSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0R6-GATA_HUMAN
    Recommended name:
    Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
    Protein Accession:
    Q9H0R6
    Secondary Accessions:
    • Q5VWJ4
    • Q9HA60
    • Q9NV19

    Protein attributes for QRSL1 Gene

    Size:
    528 amino acids
    Molecular mass:
    57460 Da
    Quaternary structure:
    • Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits
    SequenceCaution:
    • Sequence=CAH72094.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for QRSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QRSL1 Gene

Proteomics data for QRSL1 Gene at MOPED

Post-translational modifications for QRSL1 Gene

No Post-translational modifications

Other Protein References for QRSL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for QRSL1 Gene

Domains for QRSL1 Gene

Protein Domains for QRSL1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

GATA_HUMAN
Family:
  • Belongs to the amidase family. GatA subfamily.:
    • Q9H0R6
genes like me logo Genes that share domains with QRSL1: view

No data available for Gene Families for QRSL1 Gene

Function for QRSL1 Gene

Molecular function for QRSL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
UniProtKB/Swiss-Prot Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Enzyme Numbers (IUBMB) for QRSL1 Gene

Gene Ontology (GO) - Molecular Function for QRSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor --
GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA 19805282
genes like me logo Genes that share ontologies with QRSL1: view

Phenotypes for QRSL1 Gene

GenomeRNAi human phenotypes for QRSL1:
genes like me logo Genes that share phenotypes with QRSL1: view

miRNA for QRSL1 Gene

miRTarBase miRNAs that target QRSL1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for QRSL1 Gene

Localization for QRSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QRSL1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QRSL1 Gene COMPARTMENTS Subcellular localization image for QRSL1 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for QRSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 19805282
GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex IDA 19805282
genes like me logo Genes that share ontologies with QRSL1: view

Pathways for QRSL1 Gene

SuperPathways for QRSL1 Gene

genes like me logo Genes that share pathways with QRSL1: view

Pathways by source for QRSL1 Gene

2 KEGG pathways for QRSL1 Gene

Gene Ontology (GO) - Biological Process for QRSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0008152 metabolic process --
GO:0032543 mitochondrial translation IMP 19805282
GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation IDA 19805282
genes like me logo Genes that share ontologies with QRSL1: view

Compounds for QRSL1 Gene

(1) HMDB Compounds for QRSL1 Gene

Compound Synonyms Cas Number PubMed IDs
L-Glutamine
  • (2S)-2,5-diamino-5-oxopentanoic acid
56-85-9
genes like me logo Genes that share compounds with QRSL1: view

Transcripts for QRSL1 Gene

mRNA/cDNA for QRSL1 Gene

Unigene Clusters for QRSL1 Gene

Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QRSL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3: -
SP4: -

Relevant External Links for QRSL1 Gene

GeneLoc Exon Structure for
QRSL1
ECgene alternative splicing isoforms for
QRSL1

Expression for QRSL1 Gene

mRNA expression in normal human tissues for QRSL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for QRSL1 Gene

SOURCE GeneReport for Unigene cluster for QRSL1 Gene Hs.406917

genes like me logo Genes that share expressions with QRSL1: view

Orthologs for QRSL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QRSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QRSL1 36
  • 99.62 (n)
  • 100 (a)
QRSL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia QRSL1 36
  • 89.86 (n)
  • 93.35 (a)
QRSL1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QRSL1 36
  • 91.46 (n)
  • 92.79 (a)
QRSL1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qrsl1 36
  • 84.99 (n)
  • 88.74 (a)
Qrsl1 16
Qrsl1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia QRSL1 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QRSL1 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Qrsl1 36
  • 83.91 (n)
  • 87.79 (a)
chicken
(Gallus gallus)
Aves QRSL1 36
  • 75.51 (n)
  • 79.39 (a)
QRSL1 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QRSL1 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia qrsl1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia qrsl1 36
  • 70.75 (n)
  • 74.9 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12246 36
qrsl1 36
  • 65.76 (n)
  • 66.86 (a)
qrsl1 37
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004057 36
  • 55.53 (n)
  • 56.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta gatA 36
  • 54.5 (n)
  • 55.26 (a)
gatA 37
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y41D4A.6 36
  • 54.08 (n)
  • 50.98 (a)
Y41D4A.6 37
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR140C 36
  • 44.62 (n)
  • 39.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HER2 36
  • 45.81 (n)
  • 36.68 (a)
HER2 37
  • 32 (a)
OneToOne
HER2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09845g 36
  • 46.39 (n)
  • 36.67 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G25660 36
  • 48.34 (n)
  • 42.21 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00660 36
  • 45.63 (n)
  • 41.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC646.03 36
  • 45.9 (n)
  • 36.18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13009 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 16 (a)
OneToOne
Species with no ortholog for QRSL1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QRSL1 Gene

ENSEMBL:
Gene Tree for QRSL1 (if available)
TreeFam:
Gene Tree for QRSL1 (if available)

Paralogs for QRSL1 Gene

Pseudogenes.org Pseudogenes for QRSL1 Gene

genes like me logo Genes that share paralogs with QRSL1: view

No data available for Paralogs for QRSL1 Gene

Variants for QRSL1 Gene

Sequence variations from dbSNP and Humsavar for QRSL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs727104 -- 106,637,731(-) GTTTT(C/T)GTTAA intron-variant
rs1026619 -- 106,666,486(-) CTTAC(C/T)AAATG utr-variant-3-prime
rs1026621 -- 106,665,528(-) gtttt(A/C)ccata intron-variant
rs1056621 -- 106,667,963(+) AAAAA(A/G)AAGAG utr-variant-3-prime
rs1419054 -- 106,637,066(-) agcaa(C/T)acctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QRSL1 Gene

Variant ID Type Subtype PubMed ID
nsv516902 CNV Loss 19592680

Relevant External Links for QRSL1 Gene

HapMap Linkage Disequilibrium report
QRSL1

Disorders for QRSL1 Gene

(1) MalaCards Diseases for QRSL1 Gene

Search for QRSL1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for QRSL1 Gene

Relevant External Links for QRSL1

Genetic Association Database (GAD)
QRSL1
Human Genome Epidemiology (HuGE) Navigator
QRSL1
genes like me logo Genes that share disorders with QRSL1: view

No data available for UniProtKB/Swiss-Prot for QRSL1 Gene

Publications for QRSL1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. (PMID: 19805282) Nagao A. … Suzuki T. (Proc. Natl. Acad. Sci. U.S.A. 2009) 2 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for QRSL1 Gene

Sources for QRSL1 Gene

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