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Aliases for QRSL1 Gene

Aliases for QRSL1 Gene

  • Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 1 2 3 5
  • Glutaminyl-TRNA Synthase-Like Protein 1 3 4
  • Glu-AdT Subunit A 3 4
  • Glutamyl-TRNA(Gln) Amidotransferase Subunit A Homolog 3
  • Glutamyl-TRNA(Gln) Amidotransferase, Subunit A 3
  • Glutamyl-TRNA(Gln) Amidotransferase 2
  • EC 6.3.5.7 4
  • Subunit A 2
  • GatA 3

External Ids for QRSL1 Gene

Previous GeneCards Identifiers for QRSL1 Gene

  • GC06P107077
  • GC06P107123
  • GC06P107185
  • GC06P104524

Summaries for QRSL1 Gene

GeneCards Summary for QRSL1 Gene

QRSL1 (Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 1) is a Protein Coding gene. Among its related pathways are Metabolism and tRNA Aminoacylation. GO annotations related to this gene include carbon-nitrogen ligase activity, with glutamine as amido-N-donor and glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity.

UniProtKB/Swiss-Prot for QRSL1 Gene

  • Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRSL1 Gene

Genomics for QRSL1 Gene

Regulatory Elements for QRSL1 Gene

Enhancers for QRSL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around QRSL1 on UCSC Golden Path with GeneCards custom track

Promoters for QRSL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around QRSL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for QRSL1 Gene

Chromosome:
6
Start:
106,629,566 bp from pter
End:
106,668,417 bp from pter
Size:
38,852 bases
Orientation:
Plus strand

Genomic View for QRSL1 Gene

Genes around QRSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QRSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QRSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRSL1 Gene

Proteins for QRSL1 Gene

  • Protein details for QRSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0R6-GATA_HUMAN
    Recommended name:
    Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
    Protein Accession:
    Q9H0R6
    Secondary Accessions:
    • Q5VWJ4
    • Q9HA60
    • Q9NV19

    Protein attributes for QRSL1 Gene

    Size:
    528 amino acids
    Molecular mass:
    57460 Da
    Quaternary structure:
    • Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.
    SequenceCaution:
    • Sequence=CAH72094.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for QRSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QRSL1 Gene

Proteomics data for QRSL1 Gene at MOPED

Post-translational modifications for QRSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for QRSL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for QRSL1 Gene

Domains & Families for QRSL1 Gene

Protein Domains for QRSL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for QRSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0R6

UniProtKB/Swiss-Prot:

GATA_HUMAN :
  • Belongs to the amidase family. GatA subfamily.
Family:
  • Belongs to the amidase family. GatA subfamily.
genes like me logo Genes that share domains with QRSL1: view

No data available for Gene Families for QRSL1 Gene

Function for QRSL1 Gene

Molecular function for QRSL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
UniProtKB/Swiss-Prot Function:
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).

Enzyme Numbers (IUBMB) for QRSL1 Gene

Gene Ontology (GO) - Molecular Function for QRSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with QRSL1: view
genes like me logo Genes that share phenotypes with QRSL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for QRSL1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QRSL1 Gene

Localization for QRSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for QRSL1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QRSL1 Gene COMPARTMENTS Subcellular localization image for QRSL1 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for QRSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 19805282
genes like me logo Genes that share ontologies with QRSL1: view

Pathways & Interactions for QRSL1 Gene

SuperPathways for QRSL1 Gene

genes like me logo Genes that share pathways with QRSL1: view

Pathways by source for QRSL1 Gene

2 KEGG pathways for QRSL1 Gene

Gene Ontology (GO) - Biological Process for QRSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0032543 mitochondrial translation IEA,IMP 19805282
genes like me logo Genes that share ontologies with QRSL1: view

No data available for SIGNOR curated interactions for QRSL1 Gene

Drugs & Compounds for QRSL1 Gene

(3) Drugs for QRSL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist 0
L-Glutamic Acid Nutra Full agonist, Agonist 0

(2) Additional Compounds for QRSL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with QRSL1: view

Transcripts for QRSL1 Gene

Unigene Clusters for QRSL1 Gene

Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QRSL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3: -
SP4: -

Relevant External Links for QRSL1 Gene

GeneLoc Exon Structure for
QRSL1
ECgene alternative splicing isoforms for
QRSL1

Expression for QRSL1 Gene

mRNA expression in normal human tissues for QRSL1 Gene

Protein differential expression in normal tissues from HIPED for QRSL1 Gene

This gene is overexpressed in Heart (39.9), Plasma (13.3), and Lung (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for QRSL1 Gene



SOURCE GeneReport for Unigene cluster for QRSL1 Gene Hs.406917

genes like me logo Genes that share expression patterns with QRSL1: view

Protein tissue co-expression partners for QRSL1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for QRSL1 Gene

Orthologs for QRSL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QRSL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia QRSL1 35
  • 89.86 (n)
  • 93.35 (a)
QRSL1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QRSL1 35
  • 91.46 (n)
  • 92.79 (a)
QRSL1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qrsl1 35
  • 84.99 (n)
  • 88.74 (a)
Qrsl1 16
Qrsl1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia QRSL1 35
  • 99.62 (n)
  • 100 (a)
QRSL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Qrsl1 35
  • 83.91 (n)
  • 87.79 (a)
oppossum
(Monodelphis domestica)
Mammalia QRSL1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QRSL1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves QRSL1 35
  • 75.51 (n)
  • 79.39 (a)
QRSL1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QRSL1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qrsl1 35
  • 70.75 (n)
  • 74.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia qrsl1-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12246 35
qrsl1 35
  • 65.76 (n)
  • 66.86 (a)
qrsl1 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004057 35
  • 55.53 (n)
  • 56.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta gatA 35
  • 54.5 (n)
  • 55.26 (a)
gatA 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y41D4A.6 35
  • 54.08 (n)
  • 50.98 (a)
Y41D4A.6 36
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR140C 35
  • 44.62 (n)
  • 39.17 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09845g 35
  • 46.39 (n)
  • 36.67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HER2 35
  • 45.81 (n)
  • 36.68 (a)
HER2 36
  • 32 (a)
OneToOne
HER2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G25660 35
  • 48.34 (n)
  • 42.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13009 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00660 35
  • 45.63 (n)
  • 41.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC646.03 35
  • 45.9 (n)
  • 36.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToOne
Species with no ortholog for QRSL1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QRSL1 Gene

ENSEMBL:
Gene Tree for QRSL1 (if available)
TreeFam:
Gene Tree for QRSL1 (if available)

Paralogs for QRSL1 Gene

Pseudogenes.org Pseudogenes for QRSL1 Gene

genes like me logo Genes that share paralogs with QRSL1: view

No data available for Paralogs for QRSL1 Gene

Variants for QRSL1 Gene

Sequence variations from dbSNP and Humsavar for QRSL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs36016898 - 106,640,356(-) GTGCC(A/G)CAGAA reference, missense, utr-variant-5-prime
rs34221917 - 106,652,521(-) GTTTA(C/T)TAATA reference, missense
rs1026619 -- 106,666,486(-) CTTAC(C/T)AAATG utr-variant-3-prime
rs1026621 -- 106,665,528(-) gtttt(A/C)ccata intron-variant
rs1056621 -- 106,667,963(+) AAAAA(A/G)AAGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for QRSL1 Gene

Variant ID Type Subtype PubMed ID
nsv516902 CNV Loss 19592680

Variation tolerance for QRSL1 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for QRSL1 Gene

Disorders for QRSL1 Gene

Relevant External Links for QRSL1

Genetic Association Database (GAD)
QRSL1
Human Genome Epidemiology (HuGE) Navigator
QRSL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QRSL1

No disorders were found for QRSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QRSL1 Gene

Publications for QRSL1 Gene

  1. Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. (PMID: 19805282) Nagao A. … Suzuki T. (Proc. Natl. Acad. Sci. U.S.A. 2009) 2 3 4 67
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3
  3. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  5. Prominent role of NF-kappaB in the induction of endothelial activation by endogenous nitric oxide inhibition. (PMID: 19654051) Lazzerini G. … Caterina R.D. (Nitric Oxide 2009) 23

Products for QRSL1 Gene

Sources for QRSL1 Gene

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