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QRSL1 Gene

protein-coding   GIFtS: 58
GCID: GC06P107077

Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 11 2     Glutamyl-TRNA(Gln) Amidotransferase Subunit A Homolog2
Glu-AdT Subunit A2 3     Glutamyl-TRNA(Gln) Amidotransferase Subunit A, Mitochondrial2
Glutaminyl-TRNA Synthase-Like Protein 12 3     EC 6.3.5.73
GatA2     

External Ids:    HGNC: 210201   Entrez Gene: 552782   Ensembl: ENSG000001303487   UniProtKB: Q9H0R63   

Export aliases for QRSL1 gene to outside databases

Previous GC identifers: GC06P107123 GC06P107185 GC06P104524


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for QRSL1 Gene:
QRSL1 (glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1) is a protein-coding gene. Diseases associated with QRSL1 include lymphogranuloma venereum, and intestinal volvulus. GO annotations related to this gene include glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity.

UniProtKB/Swiss-Prot: GATA_HUMAN, Q9H0R6
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated
Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an
activated gamma-phospho-Glu-tRNA(Gln)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the QRSL1 gene promoter:
         COUP-TF1   GATA-3   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   CREB   COUP-TF   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQRSL1 promoter sequence
   Search Chromatin IP Primers for QRSL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat QRSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

QRSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QRSL1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P107077:  view genomic region     (about GC identifiers)

Start:
107,077,441 bp from pter      End:
107,116,292 bp from pter
Size:
38,852 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GATA_HUMAN, Q9H0R6 (See protein sequence)
Recommended Name: Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial  
Size: 528 amino acids; 57460 Da
Subunit: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (PET112)
and C (GATC) subunits
Sequence caution: Sequence=CAH72094.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5VWJ4 Q9HA60 Q9NV19
Alternative splicing: 2 isoforms:  Q9H0R6-1   Q9H0R6-2   

Explore the universe of human proteins at neXtProt for QRSL1: NX_Q9H0R6

Explore proteomics data for QRSL1 at MOPED


See QRSL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060762.3  
ENSEMBL proteins: 
 ENSP00000358042   ENSP00000358040  

QRSL1 Human Recombinant Protein Products:

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Novus Biologicals QRSL1 Protein
Novus Biologicals QRSL1 Lysates
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Cloud-Clone Corp. Proteins for QRSL1

QRSL1 Antibody Products:

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Abcam antibodies for QRSL1
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LSBio Antibodies in human, mouse, rat for QRSL1

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Cloud-Clone Corp. CLIAs for QRSL1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR000120 Amidase
 IPR023631 Amidase_dom
 IPR004412 GatA

Graphical View of Domain Structure for InterPro Entry Q9H0R6

ProtoNet protein and cluster: Q9H0R6

1 Blocks protein domain: IPB000120 Amidase

UniProtKB/Swiss-Prot: GATA_HUMAN, Q9H0R6
Similarity: Belongs to the amidase family. GatA subfamily


QRSL1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: GATA_HUMAN, Q9H0R6
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated
Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an
activated gamma-phospho-Glu-tRNA(Gln)
Catalytic activity: ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) +
L-glutamate

     Enzyme Number (IUBMB): EC 6.3.5.71

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005524ATP binding IEA--
GO:0016884carbon-nitrogen ligase activity, with glutamine as amido-N-donor ----
GO:0050567glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA19805282
     
QRSL1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for QRSL1:
 Increased S DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for QRSL1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for QRSL1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for QRSL1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for QRSL1

miRNA
Products:
    
miRTarBase miRNAs that target QRSL1:
hsa-mir-769-5p (MIRT039213), hsa-let-7b-5p (MIRT032250)

Block miRNA regulation of human, mouse, rat QRSL1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate QRSL1 (see all 11):
hsa-miR-579 hsa-miR-7-2* hsa-miR-1324 hsa-miR-1236 hsa-miR-520a-5p hsa-miR-10b* hsa-miR-3681 hsa-miR-525-5p
SwitchGear 3'UTR luciferase reporter plasmidQRSL1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for QRSL1
Predesigned siRNA for gene silencing in human, mouse, rat QRSL1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for QRSL1

Clone
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OriGene ORF clones in mouse, rat for QRSL1
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GenScript: all cDNA clones in your preferred vector: QRSL1 (NM_018292)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for QRSL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRSL1

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for QRSL1 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRSL1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
GATA_HUMAN, Q9H0R6: Mitochondrion
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytoskeleton2
nucleus2
cytosol1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA19805282
GO:0030956glutamyl-tRNA(Gln) amidotransferase complex IDA19805282

QRSL1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for QRSL1 About    
See pathways by source

SuperPathContained pathways About
1tRNA Aminoacylation
Aminoacyl-tRNA biosynthesis0.52
2Metabolism
Metabolic pathways0.38

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2 Kegg Pathways  (Kegg details for QRSL1):
    Aminoacyl-tRNA biosynthesis
Metabolic pathways


QRSL1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for QRSL1
Interactions:

    Search GeneGlobe Interaction Network for QRSL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for QRSL1 (Q9H0R62, 3 ENSP000003580424) via UniProtKB, MINT, STRING, and/or I2D (see all 164)
InteractantInteraction Details
GeneCardExternal ID(s)
HIST1H4AP628053I2D: score=1 
HIST1H4BP628053I2D: score=1 
HIST1H4CP628053I2D: score=1 
HIST1H4DP628053I2D: score=1 
HIST1H4EP628053I2D: score=1 
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006412translation ----
GO:0032543mitochondrial translation IMP19805282
GO:0070681glutaminyl-tRNAGln biosynthesis via transamidation IDA19805282

QRSL1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for QRSL1 (GATA)

1 HMDB Compound for QRSL1    About this table
CompoundSynonyms CAS #PubMed Ids
L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for QRSL1 gene: 
NM_018292.4  

Unigene Cluster for QRSL1:

Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Hs.406917  [show with all ESTs]
Unigene Representative Sequence: NM_018292
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000369046(uc003prm.3) ENST00000467262 ENST00000369044(uc003prl.2)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat QRSL1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate QRSL1 (see all 11):
hsa-miR-579 hsa-miR-7-2* hsa-miR-1324 hsa-miR-1236 hsa-miR-520a-5p hsa-miR-10b* hsa-miR-3681 hsa-miR-525-5p
SwitchGear 3'UTR luciferase reporter plasmidQRSL1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for QRSL1
Predesigned siRNA for gene silencing in human, mouse, rat QRSL1
Clone
Products:
     
OriGene clones in human, mouse for QRSL1 (see all 8)
OriGene ORF clones in mouse, rat for QRSL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: QRSL1 (NM_018292)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for QRSL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRSL1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for QRSL1
OriGene qSTAR qPCR primer pairs in human, mouse for QRSL1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat QRSL1
  QuantiTect SYBR Green Assays in human, mouse, rat QRSL1
  QuantiFast Probe-based Assays in human, mouse, rat QRSL1

Additional mRNA sequence: 

AK001851.1 AK022251.1 AK023509.1 AK055349.1 AK225262.1 AK225443.1 AK314694.1 AL136679.1 
BC006084.1 BC014389.2 

11 DOTS entries:

DT.443382  DT.100792867  DT.100670980  DT.95278114  DT.95278116  DT.95319561  DT.100717177  DT.100023319 
DT.100806027  DT.91755953  DT.95278113 

Selected AceView cDNA sequences (see all 174):

BC006084 AW337453 AW074834 BX350644 AK001851 BE326616 CR592831 AA769438 
BG206368 BU619644 AW006165 R94566 AI564684 N66117 AK022251 CR618052 
BC014389 BP365015 AW612708 BF879325 BG194540 BM802270 BG185173 AK023509 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for QRSL1    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1:                    -                 -                                                         
SP2:                                                                    -                           
SP3:                                      -                                                         
SP4:                    -                                                                           


ECgene alternative splicing isoforms for QRSL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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QRSL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGAGAAAATT
QRSL1 Expression
About this image


QRSL1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 10) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
QRSL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

QRSL1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.406917
    Custom PCR Arrays for QRSL1
Primer
Products:
OriGene qPCR primer pairs and template standards for QRSL1
OriGene qSTAR qPCR primer pairs in human, mouse for QRSL1
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QuantiTect SYBR Green Assays in human, mouse, rat QRSL1
QuantiFast Probe-based Assays in human, mouse, rat QRSL1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRSL1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for QRSL1 gene from Selected species (see all 23)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Qrsl11 , 5 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like more1, 5 84.99(n)1
88.74(a)1
  10 (23.11 cM)5
765631  NM_001081054.21  NP_001074523.11 
 438741885 
chicken
(Gallus gallus)
Aves QRSL11 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like more 75.51(n)
79.39(a)
  421781  XM_419807.3  XP_419807.2 
lizard
(Anolis carolinensis)
Reptilia QRSL16
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-l...
78(a)
1 ↔ 1
1(189474632-189509430)
African clawed frog
(Xenopus laevis)
Amphibia qrsl1-prov2 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like more 75.82(n)    BC042285.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.122462 Danio rerio, Similar to RIKEN cDNA 2700038P16 gene, more 76.47(n)    BC044563.1 
fruit fly
(Drosophila melanogaster)
Insecta gatA1 glutamyl-tRNA amidotransferase subunit A 54.5(n)
55.26(a)
  42283  NM_142518.3  NP_650775.2 
worm
(Caenorhabditis elegans)
Secernentea Y41D4A.61 Y41D4A.6 54.08(n)
50.98(a)
  176982  NM_067728.5  NP_500129.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HER2(YMR293C)4
HER21
Subunit of the trimeric GatFAB AmidoTransferase(AdT) more4
HER21
45.81(n)1
36.68(a)1
  13(856793-855399)4
8553381, 4  NP_014021.11, 4 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G256601 AT3G25660 48.34(n)
42.21(a)
  822154  NM_113465.3  NP_189194.1 


ENSEMBL Gene Tree for QRSL1 (if available)
TreeFam Gene Tree for QRSL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for QRSL1 gene

QRSL1 for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for QRSL1
PGOHUM00000248135 PGOHUM00000244326 PGOHUM00000244436


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for QRSL1 (see all 837)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1501218741,2
C--107079379(+) GAATCA/GGTTAT 1 -- int10--------
rs69051341,2
C,F,H--107079398(+) acaagG/Aatcag 1 -- int14Minor allele frequency- A:0.00NS EA 420
rs1452828161,2
C--107079537(+) GTTTT-/ATAAAA 1 -- int10--------
rs588919871,2
C--107079538(+) GTTTTA/TAAAAA 1 -- int10--------
rs679285031,2
F--107079547(+) AAAAAA/TTTTTA 1 -- int11Minor allele frequency- T:0.05NA 120
rs69050611,2
C--107079560(+) gggtaC/Tatagt 1 -- int14Minor allele frequency- T:0.21CSA WA EA 240
rs1149825861,2
C,F--107079681(+) TTGTGT/GTACAA 1 -- int11Minor allele frequency- G:0.06WA 118
rs1384365991,2
--107079818(+) CCCATC/TCCCAC 1 -- int10--------
rs1492496861,2
C--107079883(+) CCTCCA/GCGAGG 1 -- int10--------
rs1444290391,2
--107080005(+) TTGCAA/GTTGAC 1 -- int10--------

HapMap Linkage Disequilibrium report for QRSL1 (107077441 - 107116292 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for QRSL1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv516902CNV Loss19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing QRSL1
DNA2.0 Custom Variant and Variant Library Synthesis for QRSL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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12 diseases for QRSL1:    
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lymphogranuloma venereum    intestinal volvulus    trachoma    cleft lip
pneumonia    tonsillitis    tuberculosis    endotheliitis
malaria    thyroiditis    cerebritis    prostatitis

1 disease from the University of Copenhagen DISEASES database for QRSL1:
Lymphogranuloma venereum

QRSL1 for disorders           About GeneDecksing

Genetic Association Database (GAD): QRSL1
Human Genome Epidemiology (HuGE) Navigator: QRSL1 (3 documents)

Export disorders for QRSL1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for QRSL1 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with QRSL1)
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  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  3. Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. (PubMed id 19805282)1, 2 Nagao A.... Suzuki T. (Proc. Natl. Acad. Sci. U.S.A. 2009)
  4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55278 HGNC: 21020 AceView: QRSL1 Ensembl:ENSG00000130348 euGenes: HUgn55278
ECgene: QRSL1 Kegg: 55278 H-InvDB: QRSL1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for QRSL1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for QRSL1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for QRSL1 gene:
Search GeneIP for patents involving QRSL1

GeneCards and IP:
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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