QRSL1 Gene
protein-coding GIFtS: 52
GCID: GC06P107077
|
|
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
| |
Aliases
for QRSL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutaminyl-TRNA Synthase (Glutamine-Hydrolyzing)-Like 11 2 | | FLJ121891 | | GatA1 2 | | FLJ134471 | | Glu-AdT Subunit A2 3 | | Glutamyl-TRNA(Gln) Amidotransferase Subunit A Homolog2 | | Glutaminyl-TRNA Synthase-Like Protein 12 3 | | Glutamyl-TRNA(Gln) Amidotransferase Subunit A, Mitochondrial2 | | DKFZP564C12781 | | EC 6.3.5.-3 | | FLJ109891 | | |
Export aliases for QRSL1 gene to outside databasesPrevious GC identifers: GC06P107123 GC06P107185 GC06P104524 |
Summaries
for QRSL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GATA_HUMAN, Q9H0R6Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylatedGlu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activatedgamma-phospho-Glu-tRNA(Gln)
|
Genomic Views
for QRSL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the QRSL1 gene promoter:
COUP-TF1 GATA-3 COUP HNF-4alpha2 Nkx2-5 HNF-4alpha1 CREB COUP-TF deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for QRSL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRSL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21QRSL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P107077: view genomic region
(about GC identifiers)
Start:
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107,077,441 bp from pter |
End:
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107,116,292 bp from pter |
Size:
|
38,852 bases |
Orientation:
|
plus strand |
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Proteins
for QRSL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GATA_HUMAN, Q9H0R6 (See
protein sequence)Recommended Name: Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial Size: 528 amino acids; 57460 Da
Subunit: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (PET112) and C(GATC) subunits
Subcellular location: Mitochondrion
Sequence caution: Sequence=CAH72094.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5VWJ4 Q9HA60 Q9NV19Alternative splicing: 2 isoforms: Q9H0R6-1 Q9H0R6-2 Explore the universe of human proteins at neXtProt for QRSL1: NX_Q9H0R6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0R6
QRSL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060762.3
ENSEMBL proteins: ENSP00000358042 ENSP00000358040
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
QRSL1 for ontologies About GeneDecksing
QRSL1 Antibody Products:
Assay Products for QRSL1: |
Protein
Domains /
Families
for QRSL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
QRSL1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0R6ProtoNet protein and cluster: Q9H0R6 1 Blocks protein family: IPB000120 Amidase
UniProtKB/Swiss-Prot: GATA_HUMAN, Q9H0R6Similarity: Belongs to the amidase family. GatA subfamily |
Function
for QRSL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GATA_HUMAN, Q9H0R6Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylatedGlu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activatedgamma-phospho-Glu-tRNA(Gln)Catalytic activity: ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamateEnzyme Number (IUBMB): EC 6.3.5.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRSL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRSL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: QRSL1 (NM_018292) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for QRSL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRSL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRSL1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0050567 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
IDA | 19805282 |
QRSL1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for QRSL1:
|
Pathways & Interactions
for QRSL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QRSL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/148 Interacting proteins for QRSL1 (Q9H0R62, 3 ENSP000003580424) via UniProtKB, MINT, STRING, and/or I2D (see all 148)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
QRSL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for QRSL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for QRSL1
1 HMDB Compound for QRSL1 About this table
Search CenterWatch for drugs/clinical trials and news about QRSL1 / GATA
|
Transcripts
for QRSL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for QRSL1 gene: NM_018292.4 Unigene Cluster for QRSL1: Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 Hs.406917 [show with all ESTs]Unigene Representative Sequence: NM_0182923 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369046(uc003prm.3) ENST00000467262 ENST00000369044(uc003prl.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRSL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRSL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: QRSL1 (NM_018292) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for QRSL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRSL1 |
Additional cDNA sequence: AK001851.1 AK022251.1 AK023509.1 AK055349.1 AK225262.1 AK225443.1 AK314694.1 AL136679.1 BC006084.1 BC014389.2 11 DOTS entries: DT.443382 DT.100792867 DT.100670980 DT.95278114 DT.95278116 DT.95319561 DT.100717177 DT.100023319 DT.100806027 DT.91755953 DT.95278113 24/174 AceView cDNA sequences (see all 174): BP365015 CR592831 BC006084 CR598150 AU121726 AI564684 BX377832 BX099642 BM802270 BF223880 AK022251 BF879325 BE891356 AA602557 BG036566 AW006165 AK023509 AW612708 BE326616 BG206368 AW337453 AA961015 BX350644 N66117
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for QRSL1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for QRSL1
|
Expression
for QRSL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| QRSL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGAAAATT
About this image
See QRSL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for QRSL1
SOURCE GeneReport for Unigene cluster: Hs.406917
SABiosciences Custom PCR Arrays for QRSL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for QRSL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat QRSL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QRSL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QRSL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRSL1 |
Orthologs
for QRSL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for QRSL1 gene from 9/36 species (see all 36) About this table
ENSEMBL Gene Tree for QRSL1 (if available)
TreeFam Gene Tree for QRSL1 (if available) |
Paralogs
for QRSL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for QRSL1 gene
QRSL1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for QRSL1
PGOHUM00000248135 PGOHUM00000244326 PGOHUM00000244436
|
Genomic Variants
for QRSL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for QRSL1 (107077441 - 107116292 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for QRSL1
1 CNV: 51782 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QRSL1 |
|
Disorders
/ Diseases
for QRSL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
QRSL1 for disorders About GeneDecksing
9  diseases for QRSL1: About MalaCardslymphogranuloma venereum cleft lip/palate intestinal volvulus cleft lip
trachoma pneumonia tuberculosis malaria
mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for QRSL1:Lymphogranuloma venereum Human Genome Epidemiology (HuGE) Navigator: QRSL1 (3 documents)
Export disorders for QRSL1 gene to outside databases
|
Publications
for QRSL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for QRSL1 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with QRSL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Biogenesis of glutaminyl-mt tRNAGln in human mitochon dria. (PubMed id 19805282)1, 2 Nagao A....Suzuki T. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1 Vieira A.R....Marazita M.L. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
|
External Searches for QRSL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing QRSL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing QRSL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QRSL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for QRSL1 gene:
Search GeneIP for patents involving QRSL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for QRSL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat QRSL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QRSL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRSL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QRSL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QRSL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QRSL1 |
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 | | | QRSL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRSL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for QRSL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRSL1 |
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