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Aliases for QRICH2 Gene

Aliases for QRICH2 Gene

  • Glutamine Rich 2 2 3 5

External Ids for QRICH2 Gene

Previous GeneCards Identifiers for QRICH2 Gene

  • GC17M071782
  • GC17M074262
  • GC17M069698

Summaries for QRICH2 Gene

GeneCards Summary for QRICH2 Gene

QRICH2 (Glutamine Rich 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRICH2 Gene

Genomics for QRICH2 Gene

Regulatory Elements for QRICH2 Gene

Enhancers for QRICH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F076258 1.7 FANTOM5 Ensembl ENCODE 20.1 +40.7 40715 19.6 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 FOS RNF157 ENSG00000267342 QRICH2 TRIM65 ENSG00000266980 UBALD2 PRPSAP1 FOXJ1 EXOC7 MFSD11
GH17F076419 1.4 FANTOM5 Ensembl ENCODE 10.8 -111.7 -111663 1.7 HDGF DRAP1 DNMT3B RARA FOSL1 SLC30A9 GATA4 FOS NR2F6 FOSL2 SPHK1 AANAT UBE2O PRPSAP1 RNU6-24P QRICH2 RNF157 MFSD11 GC17P076430 GC17M076386
GH17F076375 1.2 Ensembl ENCODE 11.9 -67.7 -67711 1.6 ATF1 MLX ARID4B DMAP1 ZNF48 SLC30A9 SP5 NFYC MXD4 MIER2 QRICH2 SPHK1 GC17P076379
GH17F076352 1.2 ENCODE 11.8 -45.4 -45379 2.8 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000267801 PRPSAP1 CASKIN2 QRICH2 SPHK1 EXOC7 UNK UBE2O AANAT TRIM47
GH17F076465 1.2 Ensembl ENCODE 11.1 -157.7 -157711 1.2 PKNOX1 CREB3L1 ARID4B DMAP1 ZSCAN9 RAD21 RARA SLC30A9 ZNF766 GLIS2 PRCD CYGB QRICH2 GC17M076452 GC17P076469
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around QRICH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for QRICH2 Gene

Chromosome:
17
Start:
76,274,049 bp from pter
End:
76,308,690 bp from pter
Size:
34,642 bases
Orientation:
Minus strand

Genomic View for QRICH2 Gene

Genes around QRICH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QRICH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QRICH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRICH2 Gene

Proteins for QRICH2 Gene

  • Protein details for QRICH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0J4-QRIC2_HUMAN
    Recommended name:
    Glutamine-rich protein 2
    Protein Accession:
    Q9H0J4
    Secondary Accessions:
    • A2RRE1
    • Q96LM3

    Protein attributes for QRICH2 Gene

    Size:
    1663 amino acids
    Molecular mass:
    180827 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71667.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for QRICH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QRICH2 Gene

Post-translational modifications for QRICH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for QRICH2 Gene

Domains & Families for QRICH2 Gene

Protein Domains for QRICH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for QRICH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with QRICH2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for QRICH2 Gene

Function for QRICH2 Gene

genes like me logo Genes that share phenotypes with QRICH2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for QRICH2 Gene

Localization for QRICH2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QRICH2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for QRICH2 Gene

Pathways & Interactions for QRICH2 Gene

SuperPathways for QRICH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for QRICH2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for QRICH2 Gene

Transcripts for QRICH2 Gene

Unigene Clusters for QRICH2 Gene

Glutamine rich 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for QRICH2 Gene

No ASD Table

Relevant External Links for QRICH2 Gene

GeneLoc Exon Structure for
QRICH2
ECgene alternative splicing isoforms for
QRICH2

Expression for QRICH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for QRICH2 Gene

mRNA differential expression in normal tissues according to GTEx for QRICH2 Gene

This gene is overexpressed in Testis (x8.2).

Protein differential expression in normal tissues from HIPED for QRICH2 Gene

This gene is overexpressed in Nasal epithelium (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for QRICH2 Gene



Protein tissue co-expression partners for QRICH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of QRICH2 Gene:

QRICH2

SOURCE GeneReport for Unigene cluster for QRICH2 Gene:

Hs.252739
genes like me logo Genes that share expression patterns with QRICH2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for QRICH2 Gene

Orthologs for QRICH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for QRICH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QRICH2 34 35
  • 98.44 (n)
mouse
(Mus musculus)
Mammalia Qrich2 34 16 35
  • 82.63 (n)
dog
(Canis familiaris)
Mammalia QRICH2 34 35
  • 81.37 (n)
cow
(Bos Taurus)
Mammalia QRICH2 34 35
  • 73.92 (n)
rat
(Rattus norvegicus)
Mammalia Qrich2 34
  • 67.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia QRICH2 35
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia QRICH2 35
  • 24 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QRICH2 35
  • 60 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
Species where no ortholog for QRICH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for QRICH2 Gene

ENSEMBL:
Gene Tree for QRICH2 (if available)
TreeFam:
Gene Tree for QRICH2 (if available)

Paralogs for QRICH2 Gene

No data available for Paralogs for QRICH2 Gene

Variants for QRICH2 Gene

Sequence variations from dbSNP and Humsavar for QRICH2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10153313 -- 76,296,795(+) aaaaa(A/T)aaata intron-variant
rs1045166 -- 76,271,202(+) AAAGT(A/G)GAGAG downstream-variant-500B, utr-variant-3-prime
rs11077809 -- 76,288,773(+) CCCAG(A/C)AAATC intron-variant
rs11077810 -- 76,289,028(+) gaacc(C/T)gggag intron-variant
rs11077811 -- 76,289,161(+) CAGCT(A/G)AATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QRICH2 Gene

Variant ID Type Subtype PubMed ID
esv21573 CNV loss 19812545
esv2430837 CNV deletion 19546169
esv2656914 CNV deletion 23128226
esv2670769 CNV deletion 23128226
esv2671805 CNV deletion 23128226
esv2673666 CNV deletion 23128226
esv2716250 CNV deletion 23290073
esv2716253 CNV deletion 23290073
esv3554793 CNV deletion 23714750
esv3554794 CNV deletion 23714750
esv3641280 CNV loss 21293372
esv3641281 CNV loss 21293372
esv3641282 CNV loss 21293372
esv3641283 CNV loss 21293372
nsv1139680 CNV duplication 24896259
nsv512502 CNV loss 21212237
nsv833547 CNV loss 17160897

Variation tolerance for QRICH2 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 24.46; 99.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for QRICH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
QRICH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRICH2 Gene

Disorders for QRICH2 Gene

Relevant External Links for QRICH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QRICH2

No disorders were found for QRICH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QRICH2 Gene

Publications for QRICH2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  2. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3 64
  3. Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PMID: 19367720) Carrascal M. … Abian J. (J. Proteome Res. 2008) 4 64
  4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for QRICH2 Gene

Sources for QRICH2 Gene

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