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QRICH2 Gene

protein-coding   GIFtS: 39
GCID: GC17M074262

Glutamine Rich 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamine Rich 21 2
Glutamine-Rich Protein 22

External Ids:    HGNC: 253261   Entrez Gene: 840742   Ensembl: ENSG000001296467   UniProtKB: Q9H0J43   

Export aliases for QRICH2 gene to outside databases

Previous GC identifers: GC17M071782 GC17M069698


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for QRICH2 Gene:
QRICH2 (glutamine rich 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the QRICH2 gene promoter:
         AhR   PPAR-gamma1   GATA-3   CUTL1   STAT5A   PPAR-gamma2   Arnt   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQRICH2 promoter sequence
   Search Chromatin IP Primers for QRICH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat QRICH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

QRICH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QRICH2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074262:  view genomic region     (about GC identifiers)

Start:
74,270,130 bp from pter      End:
74,303,761 bp from pter
Size:
33,632 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: QRIC2_HUMAN, Q9H0J4 (See protein sequence)
Recommended Name: Glutamine-rich protein 2  
Size: 1663 amino acids; 180827 Da
Sequence caution: Sequence=BAB71667.1; Type=Erroneous initiation;
Secondary accessions: A2RRE1 Q96LM3
Alternative splicing: 3 isoforms:  Q9H0J4-1   Q9H0J4-2   Q9H0J4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for QRICH2: NX_Q9H0J4

Explore proteomics data for QRICH2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See QRICH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115510.1  
    ENSEMBL proteins: 
     ENSP00000262765   ENSP00000394461   ENSP00000432679   ENSP00000433329  

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    antibodies-online kits for QRICH2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9H0J4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for QRICH2:
     Increased G2M DNA content, inc  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for QRICH2

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    SwitchGear 3'UTR luciferase reporter plasmidQRICH2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for QRICH2
    Interactions:

        Search GeneGlobe Interaction Network for QRICH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for QRICH2 (Q9H0J43 ENSP000002627654) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044063, ENSP000002292394I2D: score=2 STRING: ENSP00000229239
    NUP98P529483, ENSP000003160324I2D: score=2 STRING: ENSP00000316032
    SSSCA1O602323, ENSP000003123184I2D: score=2 STRING: ENSP00000312318
    TSSC1Q53HC93, ENSP000003715594I2D: score=1 STRING: ENSP00000371559
    SNAI1O958633, ENSP000002440504I2D: score=2 STRING: ENSP00000244050
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for QRICH2 (QRIC2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for QRICH2 gene: 
    NM_032134.1  

    Unigene Cluster for QRICH2:

    Glutamine rich 2
    Hs.252739  [show with all ESTs]
    Unigene Representative Sequence: AL136774
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262765(uc002jrd.1 uc010dgw.1) ENST00000447564 ENST00000524722
    ENST00000532549
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate QRICH2:
    hsa-miR-4268 hsa-miR-650 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidQRICH2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for QRICH2
    Predesigned siRNA for gene silencing in human, mouse, rat QRICH2
    Clone
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat QRICH2
      QuantiFast Probe-based Assays in human, mouse, rat QRICH2

    Additional mRNA sequence: 

    AK058102.1 AL136774.1 BC131559.1 

    4 DOTS entries:

    DT.427639  DT.100680520  DT.40115274  DT.65284357 

    Selected AceView cDNA sequences (see all 27):

    AL136774 NM_032134 BX280937 BX441416 BX451481 CD515863 BQ012444 AL040290 
    BI086721 AW292249 BQ028287 BX451482 CD633692 BX451499 AI870674 AK058102 
    CD633684 BM171668 AA161125 AI185550 R62474 T85653 CD633690 T97147 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    QRICH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCCTGGGG
    QRICH2 Expression
    About this image

    QRICH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    QRICH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.252739
        Custom PCR Arrays for QRICH2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRICH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for QRICH2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Qrich21 , 5 glutamine rich 21, 5 82.63(n)1
    81.84(a)1
      11 (81.30 cM)5
    2173411  NM_001033267.21  NP_001028439.11 
     1164413255 
    lizard
    (Anolis carolinensis)
    Reptilia QRICH26
    glutamine rich 2
    60(a)
    1 ↔ 1
    2(112471964-112494244)


    ENSEMBL Gene Tree for QRICH2 (if available)
    TreeFam Gene Tree for QRICH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for QRICH2 gene
    Selected SIMAP similar genes for QRICH2 using alignment to 4 protein entries:     QRIC2_HUMAN (see all proteins) (see all similar genes):
    UBIAD1    ZNF547    MEFV    BTBD2    DCTN5    FAM210A
    NPLOC4    FOXP2    LAMB4    ZNF564    APOD    FKBP3
    NF2    UTY    ZNF737    FAM175A    CHID1    ZNF212

    Find genes that share paralogs with QRICH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for QRICH2 (see all 1068)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012664551,2
    Cuntested174287341(+) GACTCC/TTGAAA 2 K R mis11Minor allele frequency- T:0.00EU 1323
    rs1498863541,2
    Cuntested174290069(+) CCCTCC/TGTGCT 2 R G mis10--------
    rs1808841,2
    C,F,A,H--74269775(-) TGGGGT/GGCTGG 1 -- int17Minor allele frequency- G:0.47NA WA CSA EA 366
    rs1808366781,2
    --74269863(+) GCACCA/GGCCCA 1 -- int10--------
    rs1426179101,2
    --74269987(+) CCCACC/TGTCCA 1 -- int10--------
    rs718151,2
    C,F,A,H--74270069(+) GGGTAT/CTTCCC 1 -- int131Minor allele frequency- C:0.47NS EA NA WA CSA 2898
    rs118705771,2
    C,F,A,H--74270111(+) AGAGAC/AGATTC 1 -- int16Minor allele frequency- A:0.17NA WA CSA 245
    rs713822021,2
    C,F--74270112(+) GAGACG/CATTCG 1 -- int14Minor allele frequency- C:0.10NA 126
    rs1865172321,2
    --74270190(+) CCCCGA/CGTGGG 1 -- ut310--------
    rs1135399431,2
    C--74270245(+) GCCCCCT/-GTTTG 1 -- ut311Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for QRICH2 (74270130 - 74303761 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for QRICH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671805CNV Deletion23128226
    esv2673666CNV Deletion23128226
    esv2670769CNV Deletion23128226
    esv2716250CNV Deletion23290073
    esv2656914CNV Deletion23128226
    esv2430837CNV Deletion19546169
    esv2716253CNV Deletion23290073
    nsv833547CNV Loss17160897
    nsv512502CNV Loss21212237
    esv21573CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for QRICH2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with QRICH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 KAPttgen A....Gieger C. (Nat. Genet. 2013)
    3. Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PubMed id 19367720)2 Carrascal M.... Abian J. (J. Proteome Res. 2008)
    4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84074 HGNC: 25326 AceView: DKFZP434P0316 Ensembl:ENSG00000129646 euGenes: HUgn84074
    ECgene: QRICH2 H-InvDB: QRICH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for QRICH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for QRICH2 gene:
    Search GeneIP for patents involving QRICH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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