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QRICH2 Gene

protein-coding   GIFtS: 38

GC17M071782
glutamine rich 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for QRICH2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZP434P0316 1
DKFZp434P0316 2
Descriptions
glutamine rich 2 2
External Ids
HGNC: 253261
Entrez Gene: 840742
UniProtKB: Q9H0J43
Ensembl: ENSG000001296467
Search outside databases for aliases for QRICH2 gene

Summaries
for QRICH2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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   --

Genomic Location
for QRICH2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the QRICH2 gene  

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

QRICH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M071782:     (about GC identifiers)

Start:
 71,773,595 bp from pter
End:
 71,815,356 bp from pter
Size:
 41,762 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010641.15  

Proteins
for QRICH2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: QRIC2_HUMAN, Q9H0J4 (See protein sequence)
Recommended Name: Glutamine-rich protein 2  
Size: 1663 amino acids; 180827 Da
Secondary accessions: A2RRE1 Q96LM3
Alternative splicing: 3 isoforms:  Q9H0J4-1   Q9H0J4-2   Q9H0J4-3   

REFSEQ proteins: NP_115510.1  

ENSEMBL proteins: 
ENSP00000301613 ENSP00000262765 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for QRICH2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for QRICH2
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for QRICH2

Assays for QRICH2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for QRICH2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9H0J4

Gene Function
for QRICH2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (QRICH2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032134

              Applied Biosystems Silencer® siRNAs for QRICH2

              Sigma-Aldrich siRNA for QRICH2  
                     Sigma-Aldrich shRNA for QRICH2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032134
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032134
                                 untagged cDNA clone in CMV expression vector: NM_032134 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_032134

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IPI17353931
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Pathways & Interactions
for QRICH2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Interacting proteins for QRICH2 (Q9H0J41 ENSP000002627653) via UniProtKB, MINT, and/or STRING (see all 7 )
InteractantInteraction Details
GeneCardExternal ID(s)
GAPDHP044061EBI-1053637, EBI-354056
MPDU1O753521EBI-1053637, EBI-1046501
NUP98P529481EBI-1053637, EBI-295727
PANK2Q9BZ231EBI-1053637, EBI-1058434
SNAI1O958631EBI-1053637, EBI-1045459
About this table

Drugs & Compounds
for QRICH2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for QRICH2

Transcripts
for QRICH2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (QRICH2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032134

              Sigma-Aldrich siRNA for QRICH2  
                     Sigma-Aldrich shRNA for QRICH2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_032134  

REFSEQ mRNAs for QRICH2 gene: 

NM_032134.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_032134  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032134
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032134
                                 untagged cDNA clone in CMV expression vector: NM_032134 

Additional cDNA sequence: 

AK058102.1 AL136774.1 BC131559.1 

4 DOTS entries:

DT.427639  DT.100680520  DT.40115274  DT.65284357 

24/27 AceView cDNA sequences (see all 27 ):

NM_032134 BX441416 BX280937 BX451481 CD515863 AL136774 CD633692 BI086721 
BX451499 AK058102 AW292249 BQ028287 BQ012444 AI870674 BX451482 AL040290 
CD633684 BM171668 AI185550 AA161125 R62474 T97147 CD633690 T85653 

highest scoring ESTs for QRICH2:

AL136774 AA161125 BF810663 BI086721 BM171668 BQ012444 BQ028287 BX280937 CD515863 NM_032134 

Unigene Cluster for QRICH2:

Glutamine rich 2
Hs.252739  [show with all ESTs]
Unigene Representative Sequence: AL136774


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000301613  ENST00000262765  

Expression
for QRICH2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

QRICH2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for QRICH2

1 / 2 / 3

2 probe-sets matching QRICH2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

232532_at2, 3 U133-B 1 1.00 1.00 -- -- AL136774 0.80 1.00 0.91 1

232532_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCTCCTGGGG

SOURCE GeneReport for Unigene cluster: Hs.252739

Orthologs
for QRICH2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for QRICH2 gene from 4 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 QRICH21   -- glutamine rich 2 79.8(n)
69.85(a)		 475918  XM_533125.2  XP_533125.2 
chimpanzee
(Pan troglodytes)		 QRICH21   -- glutamine rich 2 99.33(n)
98.6(a)		 454902  XM_511697.2  XP_511697.2 
cow
(Bos taurus)		 LOC5302821   -- similar to glutamine rich 2 72.9(n)
63.19(a)		 530282  XM_608750.3  XP_608750.3 
mouse
(Mus musculus)		 Qrich25 11 glutamine rich 2   -- BG082327 
About this table        Species with no ortholog for QRICH2

ENSEMBL Gene Tree for QRICH2

Paralogs
for QRICH2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for QRICH2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/265 NCBI SNPs in QRICH2 are shown (see all 265 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 83)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 17 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs22790521,2
A,C,F,H,O71798799(+) GAGCTC/GTCCCA 1 E/Q mis116Minor allele frequency- G:0.50EA NA EU WA 3933
rs22790531,2
A,C,F,H,O71798984(+) TTCCAC/TGTCGG 1 H/R mis1 ese319Minor allele frequency- T:0.39EA NA EU WA 3126
--
rs65018781,2
A,C,F,H71800016(+) gaactG/Atacca 1 T/I mis14Minor allele frequency- A:0.43EU EA WA 410
rs65018801,2
A,C,F,H71801300(+) TGGCCA/GAGGGT 1 L/S mis19Minor allele frequency- G:0.43EU EA WA NA 2238
rs22790541,2
A,C,F,H71799189(+) TGGGTA/GTGTAG 1 H/Y mis1 ese318Minor allele frequency- G:0.50EA NA EU WA 4310
rs718151,2
A,C,F,H71781664(+) GGGTAC/TTTCCC 1 -- ng5111Minor allele frequency- T:0.50EU EA WA NA 964
--
rs65018741,2
A,C,H71799863(+) gctgaT/Actgca 1 D/V mis1 ese32Minor allele frequency- A:0.00EU WA 240
rs1808841,2
A,C71781370(-) TGGGGG/TGCTGG 1 -- ng510--------
--
rs65018791,2
A,C71800017(+) aactaC/TaccaG 1 I/V mis10--------
--
rs38037381,2
C71815427(+) GGGGCC/GCCCCC 1 -- ng310--------
About this table

HapMap Linkage Disequilibrium images for QRICH2 (up to first 250kb)

Disorders & Mutations
for QRICH2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for QRICH2

(Possibly Related Articles in Doctor's Guide)
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   --

Publications
for QRICH2

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for QRICH2 gene:

Search for QRICH2

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing QRICH2

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 84074 HGNC: 25326 AceView: DKFZP434P0316 Ensembl:ENSG00000129646 euGenes: HUgn84074
ECgene: QRICH2 H-InvDB: QRICH2

Other Databases showing QRICH2

(According to HUGE)
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   --

Specialized Databases showing QRICH2

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for QRICH2

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for QRICH2

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for QRICH2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for QRICH2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for QRICH2 Antibodies for QRICH2
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for QRICH2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for QRICH2

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