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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

QRICH2 Gene

protein-coding   GIFtS: 39
GCID: GC17M074262

Glutamine Rich 2

  Search for QRICH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutamine Rich 21 2
Glutamine-Rich Protein 22

External Ids:    HGNC: 253261   Entrez Gene: 840742   Ensembl: ENSG000001296467   UniProtKB: Q9H0J43   

Export aliases for QRICH2 gene to outside databases

Previous GC identifers: GC17M071782 GC17M069698


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for QRICH2 Gene: 
QRICH2 (glutamine rich 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the QRICH2 gene promoter:
         AhR   PPAR-gamma1   GATA-3   CUTL1   STAT5A   PPAR-gamma2   Arnt   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQRICH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for QRICH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRICH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

QRICH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QRICH2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074262:  view genomic region     (about GC identifiers)

Start:
74,270,130 bp from pter      End:
74,303,761 bp from pter
Size:
33,632 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: QRIC2_HUMAN, Q9H0J4 (See protein sequence)
Recommended Name: Glutamine-rich protein 2  
Size: 1663 amino acids; 180827 Da
Sequence caution: Sequence=BAB71667.1; Type=Erroneous initiation;
Secondary accessions: A2RRE1 Q96LM3
Alternative splicing: 3 isoforms:  Q9H0J4-1   Q9H0J4-2   Q9H0J4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for QRICH2: NX_Q9H0J4

Explore proteomics data for QRICH2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0J4

  • QRICH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    QRICH2 Protein Expression
    REFSEQ proteins: NP_115510.1  
    ENSEMBL proteins: 
     ENSP00000262765   ENSP00000394461   ENSP00000432679   ENSP00000433329  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9H0J4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for QRICH2:
     Increased G2M DNA content, inc  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for QRICH2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QRICH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for QRICH2 (Q9H0J43 ENSP000002627654) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAPDHP044063, ENSP000002292394I2D: score=2 STRING: ENSP00000229239
    NUP98P529483, ENSP000003160324I2D: score=2 STRING: ENSP00000316032
    SSSCA1O602323, ENSP000003123184I2D: score=2 STRING: ENSP00000312318
    TSSC1Q53HC93, ENSP000003715594I2D: score=1 STRING: ENSP00000371559
    SNAI1O958633, ENSP000002440504I2D: score=2 STRING: ENSP00000244050
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for QRICH2 (QRIC2)

    Search CenterWatch for drugs/clinical trials and news about QRICH2 / QRIC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for QRICH2 gene: 
    NM_032134.1  

    Unigene Cluster for QRICH2:

    Glutamine rich 2
    Hs.252739  [show with all ESTs]
    Unigene Representative Sequence: AL136774
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262765(uc002jrd.1 uc010dgw.1) ENST00000447564 ENST00000524722
    ENST00000532549
    miRNA
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    hsa-miR-4268 hsa-miR-650 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidQRICH2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for QRICH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QRICH2
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    GenScript: all cDNA clones in your preferred vector: QRICH2 (NM_032134)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QRICH2

    Additional mRNA sequence: 

    AK058102.1 AL136774.1 BC131559.1 

    4 DOTS entries:

    DT.427639  DT.100680520  DT.40115274  DT.65284357 

    24/27 AceView cDNA sequences (see all 27):

    CD515863 BX280937 NM_032134 AL136774 BX441416 BX451481 AI870674 BI086721 
    AK058102 CD633692 BX451482 BX451499 AL040290 BQ012444 BQ028287 AW292249 
    CD633684 AA161125 BM171668 AI185550 R62474 CD633690 T97147 T85653 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    QRICH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCCTGGGG
    QRICH2 Expression
    About this image


    See QRICH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for QRICH2

    SOURCE GeneReport for Unigene cluster: Hs.252739
        SABiosciences Custom PCR Arrays for QRICH2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRICH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for QRICH2 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Qrich25 glutamine rich 2   --   11 (81.30 cM) 116441325 
    lizard
    (Anolis carolinensis)
    Reptilia QRICH26
    Uncharacterized protein
    61(a)
    1 ↔ 1
    2(112471964-112494244)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113956
    --
    20(a)
    1 ↔ 1
    2R(13024746-13026337)


    ENSEMBL Gene Tree for QRICH2 (if available)
    TreeFam Gene Tree for QRICH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for QRICH2 gene
    18/41 SIMAP similar genes for QRICH2 using alignment to 4 protein entries:     QRIC2_HUMAN (see all proteins) (see all similar genes):
    UBIAD1    ZNF547    MEFV    BTBD2    DCTN5    FAM210A
    NPLOC4    FOXP2    LAMB4    ZNF564    APOD    FKBP3
    NF2    UTY    ZNF737    FAM175A    CHID1    ZNF212

    QRICH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1068 SNPs in QRICH2 are shown (see all 1068)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012664551,2
    Cuntested174287341(+) GACTCC/TTGAAA 2 K R mis11Minor allele frequency- T:0.00EU 1323
    rs1498863541,2
    Cuntested174290069(+) CCCTCC/TGTGCT 2 R G mis10--------
    rs1808841,2
    C,F,A,H--74269775(-) TGGGGT/GGCTGG 1 -- int17Minor allele frequency- G:0.47NA WA CSA EA 366
    rs1808366781,2
    --74269863(+) GCACCA/GGCCCA 1 -- int10--------
    rs1426179101,2
    --74269987(+) CCCACC/TGTCCA 1 -- int10--------
    rs718151,2
    C,F,A,H--74270069(+) GGGTAT/CTTCCC 1 -- int131Minor allele frequency- C:0.47NS EA NA WA CSA 2898
    rs118705771,2
    C,F,A,H--74270111(+) AGAGAC/AGATTC 1 -- int16Minor allele frequency- A:0.17NA WA CSA 245
    rs713822021,2
    C,F--74270112(+) GAGACG/CATTCG 1 -- int14Minor allele frequency- C:0.10NA 126
    rs1865172321,2
    --74270190(+) CCCCGA/CGTGGG 1 -- ut310--------
    rs1135399431,2
    C--74270245(+) GCCCCCT/-GTTTG 1 -- ut311Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for QRICH2 (74270130 - 74303761 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for QRICH2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671805CNV Deletion23128226
    esv2673666CNV Deletion23128226
    esv2670769CNV Deletion23128226
    esv2716250CNV Deletion23290073
    esv2656914CNV Deletion23128226
    esv2430837CNV Deletion19546169
    esv2716253CNV Deletion23290073
    nsv833547CNV Loss17160897
    nsv512502CNV Loss21212237
    esv21573CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for QRICH2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with QRICH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    2. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 Kottgen A....Gieger C. (2013)
    3. Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PubMed id 19367720)2 Carrascal M.... Abian J. (2008)
    4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84074 HGNC: 25326 AceView: DKFZP434P0316 Ensembl:ENSG00000129646 euGenes: HUgn84074
    ECgene: QRICH2 H-InvDB: QRICH2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for QRICH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for QRICH2 gene:
    Search GeneIP for patents involving QRICH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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