QRICH1 Gene
protein-coding GIFtS: 45
GCID: GC03M049067
|
|
glutamine-rich 1
| |
Aliases
for QRICH1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutamine-Rich 11 2 | | FLJ202591 | | Glutamine-Rich Protein 12 |
Export aliases for QRICH1 gene to outside databasesPrevious GC identifers: GC03M049043 GC03M049044 GC03M049046 GC03M049048 GC03M049051 |
Summaries
for QRICH1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for QRICH1
|
Genomic Views
for QRICH1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the QRICH1 gene promoter:
USF1 Pax-5 Sp1 Egr-1 USF2 Olf-1 USF-1:USF-2 MEF-2A USF-1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for QRICH1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRICH1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31QRICH1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M049067: view genomic region
(about GC identifiers)
Start:
|
49,067,140 bp from pter |
End:
|
49,131,796 bp from pter |
Size:
|
64,657 bases |
Orientation:
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minus strand |
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Proteins
for QRICH1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: QRIC1_HUMAN, Q2TAL8 (See
protein sequence)Recommended Name: Glutamine-rich protein 1 Size: 776 amino acids; 86436 Da
Secondary accessions: Q4G0F7 Q7L621 Q8TEA5Explore the universe of human proteins at neXtProt for QRICH1: NX_Q2TAL8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2TAL8
QRICH1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_060200.2 NP_942581.1
ENSEMBL proteins: ENSP00000378830 ENSP00000350094 ENSP00000412890 ENSP00000416133 ENSP00000413051 ENSP00000412870 ENSP00000405505
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005622 | intracellular |
-- | -- |
QRICH1 for ontologies About GeneDecksing
QRICH1 Antibody Products:
Assay Products for QRICH1: |
Protein
Domains /
Families
for QRICH1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
QRICH1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q2TAL8ProtoNet protein and cluster: Q2TAL8 UniProtKB/Swiss-Prot: QRIC1_HUMAN, Q2TAL8Similarity: Contains 1 CARD domain |
Function
for QRICH1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRICH1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRICH1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): QRICH1 (NM_017730) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for QRICH1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRICH1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRICH1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
QRICH1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for QRICH1:
|
Pathways & Interactions
for QRICH1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QRICH1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for QRICH1 (Q2TAL82, 3 ENSP000003500944) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0042981 | regulation of apoptotic process |
-- | -- |
QRICH1 for ontologies About GeneDecksing
|
Drugs & Compounds
for QRICH1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for QRICH1
Search CenterWatch for drugs/clinical trials and news about QRICH1 / QRIC1
|
Transcripts
for QRICH1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for QRICH1 gene (2 alternative transcripts): NM_017730.2 NM_198880.1 Unigene Cluster for QRICH1: Glutamine-rich 1 Hs.297389 [show with all ESTs]Unigene Representative Sequence: NM_01773014 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395443(uc010hkq.3 uc003cvu.3 uc003cvv.3) ENST00000498392
ENST00000357496 ENST00000424300 ENST00000489642 ENST00000477021 ENST00000469910
ENST00000498440 ENST00000479449 ENST00000437939 ENST00000450685 ENST00000411682
ENST00000430979 ENST00000480483
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRICH1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRICH1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): QRICH1 (NM_017730) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for QRICH1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRICH1 |
Additional cDNA sequence: AK000266.1 AK022524.1 AK025013.1 AK074313.1 AK292536.1 BC000978.2 BC098375.1 BC110855.1 BC130340.1 BC130342.1 24/30 DOTS entries (see all 30): DT.100810932 DT.95200635 DT.99931766 DT.100671257 DT.102838815 DT.120910310 DT.95251005 DT.95357027 DT.100772178 DT.100862367 DT.439799 DT.92331519 DT.120910340 DT.92050046 DT.92469812 DT.95084763 DT.100662179 DT.95310081 DT.100759072 DT.120910399 DT.120910501 DT.120910514 DT.206851 DT.304309 24/208 AceView cDNA sequences (see all 208): CA437489 BM562826 NM_017730 BI793095 BU184585 AK093259 CO250003 BG010055 BU164072 AU123132 BC000978 BE857520 AA029852 AK074313 AI304951 AA334196 CA449070 AI146581 BM836148 AK025013 BM468728 BU178310 AA548566 BG675400
GeneLoc Exon Structure
|
Expression
for QRICH1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| QRICH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTTTTTTT
About this image
See QRICH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for QRICH1
SOURCE GeneReport for Unigene cluster: Hs.297389
SABiosciences Custom PCR Arrays for QRICH1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for QRICH1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat QRICH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QRICH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QRICH1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRICH1 |
Orthologs
for QRICH1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for QRICH1 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for QRICH1 (if available)
TreeFam Gene Tree for QRICH1 (if available) |
Paralogs
for QRICH1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for QRICH1 gene
- ZMYM42 ZMYM12 ZMYM52 ZMYM32 ZMYM62 ZMYM22
QRICH1 for paralogs About GeneDecksing
|
Genomic Variants
for QRICH1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for QRICH1 (49067140 - 49131796 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for QRICH1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QRICH1 |
|
Disorders
/ Diseases
for QRICH1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
QRICH1 for disorders About GeneDecksing
1  disease for QRICH1: About MalaCardsataxia
Export disorders for QRICH1 gene to outside databases
|
Publications
for QRICH1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for QRICH1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with QRICH1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
|
External Searches for QRICH1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing QRICH1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing QRICH1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QRICH1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for QRICH1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for QRICH1 gene:
Search GeneIP for patents involving QRICH1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for QRICH1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for QRICH1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for QRICH1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for QRICH1 | | | OriGene Protein Over-expression Lysate for QRICH1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for QRICH1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRICH1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRICH1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for QRICH1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for QRICH1 | | OriGene Custom Protein Services for QRICH1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat QRICH1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QRICH1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRICH1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QRICH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QRICH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QRICH1 |
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| | | | Search Tocris compounds for QRICH1 |
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 | | | QRICH1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRICH1 |
|  |  |  | | | | ThermoFisher Antibodies for QRICH1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRICH1 |
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