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QRICH1 Gene

protein-coding GIFtS: 44

GC03M049051

glutamine-rich 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ20259 ^¹, ²
MGC131838 ^²

Descriptions
glutamine-rich 1 ^²

External Ids
HGNC: 24713¹
Entrez Gene: 54870²
UniProtKB: Q2TAL8³
Ensembl: ENSG00000198218⁷

Search outside databases for aliases for QRICH1 gene

Previous GC identifers: GC03M049043 GC03M049044 GC03M049046 GC03M049048

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the QRICH1 gene

Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31

QRICH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M049051: (about GC identifiers)

Start:	49,042,146 bp from pter
End:	49,106,508 bp from pter
Size:	64,363 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: QRIC1_HUMAN, Q2TAL8 (See protein sequence)

Recommended Name: Glutamine-rich protein 1

Size: 776 amino acids; 86436 Da

Secondary accessions: Q4G0F7 Q7L621 Q8TEA5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_060200.2 NP_942581.1

ENSEMBL proteins:

ENSP00000350094 ENSP00000378830

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (QRICH1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for QRICH1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for QRICH1
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (QRICH1)
	Novus Biologicals Antibody for FLJ20259

Assays for QRICH1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q2TAL8

UniProtKB/Swiss-Prot: QRIC1_HUMAN, Q2TAL8

Similarity: Contains 1 CARD domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QRICH1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017730

Applied Biosystems Silencer® siRNAs for QRICH1

Sigma-Aldrich siRNA for QRICH1

Sigma-Aldrich shRNA for QRICH1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for QRICH1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_017730
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_017730
untagged cDNA clones in CMV expression vector (see all 4): AK074313

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017730

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for QRICH1 (Q2TAL8²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
ATXN1 P54253² MINT-2873882
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for QRICH1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QRICH1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017730

Sigma-Aldrich siRNA for QRICH1

Sigma-Aldrich shRNA for QRICH1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_017730 NM_198880

REFSEQ mRNAs for QRICH1 gene (2 alternative transcripts):

NM_017730.2 NM_198880.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_017730 NM_198880

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_017730
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_017730
                                 untagged cDNA clones in CMV expression vector (see all 4): AK074313

Additional cDNA sequence:

AK000266.1 AK022524.1 AK025013.1 AK074313.1 AK292536.1 BC000978.2 BC098375.1 BC110855.1

BC130340.1 BC130342.1

24/30 DOTS entries (see all 30 ):

DT.100810932 DT.95200635 DT.99931766 DT.100671257 DT.102838815 DT.120910310 DT.95251005 DT.439799

DT.95357027 DT.100772178 DT.100862367 DT.92050046 DT.92331519 DT.120910340 DT.92469812 DT.95084763

DT.100662179 DT.95310081 DT.100759072 DT.120910399 DT.120910501 DT.120910514 DT.206851 DT.304309

24/208 AceView cDNA sequences (see all 208 ):

BM836148 BU178310 AI339735 BG290320 CO250003 NM_017730 AW673597 CA449090

BG290301 BU730135 BU184585 NM_198880 BQ636888 BQ716832 BG675400 AA334196

BG010055 BU172674 AX748019 AA548566 BM668511 BM562826 CA437489 BX367346

highest scoring ESTs for QRICH1:

AK074313 AW673597 BE882018 BG337005 BG340537 BG395737 BG686872 BI258546 BI461787 BI755915

Unigene Cluster for QRICH1:

Glutamine-rich 1

Hs.297389 [show with all ESTs]

Unigene Representative Sequence: NM_017730

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000357496 ENST00000395443

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

QRICH1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for QRICH1

¹ / ² / ³

4 probe-sets matching QRICH1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38362_at²^{, 3}	U95-A	1	1.00	1.00	0.63	0.98	W27545	0.40	1.00	0.76	1
81053_at²^{, 3}	U95-E	2	0.81	0.96	0.88	1.03	AI273624	0.60	1.00	0.82	1
209174_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000978	0.60	1.00	0.82	1
209174_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTTTTTTTT

SOURCE GeneReport for Unigene cluster: Hs.297389

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for QRICH1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	QRICH1¹	--	glutamine-rich 1	94.76(n) 99.61(a)	476629 XM_845811.1 XP_850904.1
chimpanzee (Pan troglodytes)	QRICH1¹	--	glutamine-rich 1	99.79(n) 100(a)	460363 XM_001161769.1 XP_001161769.1
cow (Bos taurus)	QRICH1¹	--	glutamine-rich 1	94.29(n) 98.97(a)	511970 XM_001253383.1 XP_001253384.1
mouse (Mus musculus)	Qrich1^{1, 5}	9⁵	glutamine-rich 1^{1, 5}	92.24(n)¹ 99.17(a)¹	69232¹ NM_175143.3¹ NP_780352.1¹ AK011590⁵ AK083212⁵ (see all 15)
chicken (Gallus gallus)	QRICH1¹	--	glutamine-rich 1	83.68(n) 94.17(a)	416057 XM_001233526.1 XP_001233527.1

About this table Species with no ortholog for QRICH1

ENSEMBL Gene Tree for QRICH1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for QRICH1 gene

ZMYM4² ZMYM1² ZMYM6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/275 NCBI SNPs in QRICH1 are shown (see all 275 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 30)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11718982^1,2	C	49107558(+)	`ttagcC/Tgagtg`	2	--	ng3¹		0	--	--	--	--
	rs9846123^1,2	A,C,F,H	49063116(+)	`ACTAAC/TCCAAG`	2	--	int¹		8		EU EA WA	838
	rs7626445^1,2	A,C,F,H	49089548(+)	`TTGCAT/CAAGAG`	2	--	int¹		11		NA EU EA WA	886
--	rs6787808^1,2	A,C,F,H	49054109(+)	`gtcacC/Tcaggc`	2	--	int¹		4		EU EA WA	418
	rs4974081^1,2	C,F,H	49045503(+)	`GATAGT/CTTCCA`	2	--	int¹		15		EU EA WA NA	1398
--	rs7621347^1,2	C,F,H	49085893(+)	`aatcgC/Tttgaa`	2	--	int¹		4		EU EA WA	364
--	rs4955416^1,2	C,F,H	49083432(+)	`tacctC/Tccaag`	2	--	int¹		4		EU EA WA	420
--	rs6798112^1,2	C,F,H	49068381(+)	`aaagtG/Actggg`	2	--	int¹		4		EU EA WA	412
--	rs6446218^1,2	A,C	49050517(+)	`tttttA/Taaaca`	2	--	int¹		0	--	--	--	--
--	rs7373790^1,2	A,C	49065700(+)	`gcaggC/Tggatc`	2	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for QRICH1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for QRICH1 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)³ Lim J....Zoghbi H.Y. (2006)
Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)³ Colland F....Gauthier J.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54870	HGNC: 24713	AceView: FLJ20259	Ensembl:ENSG00000198218	euGenes: HUgn54870
ECgene: QRICH1	H-InvDB: QRICH1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for QRICH1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for QRICH1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for QRICH1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for QRICH1		Antibodies for QRICH1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for QRICH1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (QRICH1)
	Antibodies (QRICH1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for QRICH1

Search Tocris compounds for QRICH1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FLJ20259

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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QRICH1 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for QRICH1

Summaries
for QRICH1

Genomic Location
for QRICH1

Proteins
for QRICH1

Protein Domains/
Families
for QRICH1

Gene Function
for QRICH1

Pathways & Interactions
for QRICH1

Drugs & Compounds
for QRICH1

Transcripts
for QRICH1

Expression
for QRICH1

Orthologs
for QRICH1

Paralogs
for QRICH1

SNPs/Variants
for QRICH1

Disorders & Mutations
for QRICH1

Medical News
for QRICH1

Publications
for QRICH1

Search for QRICH1

Genome Databases showing QRICH1

Other Databases showing QRICH1

Specialized Databases showing QRICH1

Licensable Technologies
for QRICH1

Services
for QRICH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

QRICH1 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor QRICH1

Summariesfor QRICH1

Genomic Locationfor QRICH1

Proteinsfor QRICH1

Protein Domains/Familiesfor QRICH1

Gene Functionfor QRICH1

Pathways & Interactionsfor QRICH1

Drugs & Compoundsfor QRICH1

Transcriptsfor QRICH1

Expression for QRICH1

Orthologsfor QRICH1

Paralogsfor QRICH1

SNPs/Variantsfor QRICH1

Disorders & Mutationsfor QRICH1

Medical Newsfor QRICH1

Publicationsfor QRICH1

Search for QRICH1

Genome Databases showing QRICH1

Other Databases showing QRICH1

Specialized Databases showing QRICH1

Licensable Technologiesfor QRICH1

Servicesfor QRICH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for QRICH1

Summaries
for QRICH1

Genomic Location
for QRICH1

Proteins
for QRICH1

Protein Domains/
Families
for QRICH1

Gene Function
for QRICH1

Pathways & Interactions
for QRICH1

Drugs & Compounds
for QRICH1

Transcripts
for QRICH1

Expression
for QRICH1

Orthologs
for QRICH1

Paralogs
for QRICH1

SNPs/Variants
for QRICH1

Disorders & Mutations
for QRICH1

Medical News
for QRICH1

Publications
for QRICH1

Licensable Technologies
for QRICH1

Services
for QRICH1