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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

QRFPR Gene

protein-coding   GIFtS: 54
GCID: GC04M122249

pyroglutamylated RFamide peptide receptor

(Previous name: G protein-coupled receptor 103 )
(Previous symbol: GPR103)
 Explore 3 diseases affiliated with
QRFPR via our new
 Human Malady Compendium 
Biological research products
for QRFPR
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Pyroglutamylated RFamide Peptide Receptor1 2     AQ272 3
GPR1031 2 3     SP91552 3
G Protein-Coupled Receptor 1031 2     G-Protein Coupled Receptor 1032 3
Orexigenic Neuropeptide QRFP Receptor2 3     QRFP Receptor2

External Ids:    HGNC: 155651   Entrez Gene: 841092   Ensembl: ENSG000001868677   OMIM: 6069255   UniProtKB: Q96P653   

Export aliases for QRFPR gene to outside databases

Previous GC identifers: GC04M122472 GC04M117976


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: QRFPR_HUMAN, Q96P65
Function: Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that
modulate adenylate cyclase activity and intracellular calcium levels

Gene Wiki entry for QRFPR (Pyroglutamylated RFamide peptide receptor)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the QRFPR gene promoter:
         GR   LHX3b/Lhx3b   GR-beta   SREBP-1c   POU6F1 (c2)   SREBP-1b   HEN1   SREBP-1a   LHX3a/Lhx3a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQRFPR promoter sequence
   Search SABiosciences Chromatin IP Primers for QRFPR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRFPR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q27

QRFPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QRFPR gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M122249:  view genomic region     (about GC identifiers)

Start:
122,249,797 bp from pter      End:
122,302,214 bp from pter
Size:
52,418 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: QRFPR_HUMAN, Q96P65 (See protein sequence)
Recommended Name: Pyroglutamylated RFamide peptide receptor  
Size: 431 amino acids; 49488 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAL26488.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for QRFPR: NX_Q96P65

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96P65

  • QRFPR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_937822.2  
    ENSEMBL proteins: 
     ENSP00000423369   ENSP00000377948   ENSP00000335610  
    Reactome Protein details: Q96P65
    Human Recombinant Protein Products: 
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    Uscn Proteins for QRFPR

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IC12960173


    QRFPR for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for QRFPR


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    QRFPR for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000611 NPY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q96P65

    ProtoNet protein and cluster: Q96P65

    1 Blocks protein family: IPB000611 Neuropeptide Y receptor signature

    UniProtKB/Swiss-Prot: QRFPR_HUMAN, Q96P65
    Similarity: Belongs to the G-protein coupled receptor 1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: QRFPR_HUMAN, Q96P65
    Function: Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that
    modulate adenylate cyclase activity and intracellular calcium levels

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IDA12960173
    GO:0004983neuropeptide Y receptor activity IEA--


    QRFPR for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Qrfpr):
     skeleton 

    QRFPR for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)1.00
    Peptide ligand-binding receptors0.61
    GPCR ligand binding0.75
    2Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    3G alpha (q) signalling events
    G alpha (q) signalling events1.00
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Orexin and neuropeptides FF and QRFP bind to their respective receptors
    Orexin and neuropeptides FF and QRFP bind to their respective receptors1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/9        Reactome Pathways for QRFPR (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Orexin and neuropeptides FF and QRFP bind to their respective receptors
    Signaling by GPCR



    QRFPR for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QRFPR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/124 Interacting proteins for QRFPR (Q96P653 ENSP000003356104) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTENP604843, ENSP000003610214I2D: score=1 STRING: ENSP00000361021
    CCKENSP000003356574STRING: ENSP00000335657
    GCGENSP000003876624STRING: ENSP00000387662
    GNRH1ENSP000002764144STRING: ENSP00000276414
    GPR17ENSP000002726444STRING: ENSP00000272644
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IDA12960173


    QRFPR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for QRFPR

    1 HMDB Compound for QRFPR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about QRFPR 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for QRFPR gene: 
    NM_198179.2  

    Unigene Cluster for QRFPR:

    Pyroglutamylated RFamide peptide receptor
    Hs.368977  [show with all ESTs]
    Unigene Representative Sequence: NM_198179
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507331 ENST00000394427(uc010inj.1 uc010ink.1 uc003ids.2)
    ENST00000334383 ENST00000512235(uc010inl.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat QRFPR
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate QRFPR:
    hsa-miR-607 hsa-miR-578
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QRFPR
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    Additional cDNA sequence: 

    AB109629.1 AK309337.1 BC128133.1 JF810892.1 

    4 DOTS entries:

    DT.92032599  DT.121227032  DT.92414713  DT.121227033 

    7 AceView cDNA sequences:

    AI378008 AI308124 AI307658 BG169612 NM_198179 AB109629 AF411117 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for QRFPR    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:                                -               
    SP2:                                                


    ECgene alternative splicing isoforms for QRFPR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    QRFPR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See QRFPR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for QRFPR

    SOURCE GeneReport for Unigene cluster: Hs.368977

    UniProtKB/Swiss-Prot: QRFPR_HUMAN, Q96P65
    Tissue specificity: Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and
    vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and
    medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart,
    kidney, testis and thyroid

        SABiosciences Expression via Pathway-Focused PCR Array including QRFPR: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRFPR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for QRFPR gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves QRFPR1 pyroglutamylated RFamide peptide receptor 77.33(n)
    78.59(a)
      422671  NM_001127170.1  NP_001120642.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    73(a)
    69(a)
    1 ↔ 1
    possible ortholog
    5(139234439-139275172)
    GL344580.1(6867-15398)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.172722 Transcribed sequence with weak similarity to protein more 78.94(n)    BX777694.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001494911 similar to G protein-coupled receptor 103 65.41(n)
    63.58(a)
      100149491  XM_001920007.2  XP_001920042.2 


    ENSEMBL Gene Tree for QRFPR (if available)
    TreeFam Gene Tree for QRFPR (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for QRFPR gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  PPYR12  NPY5R2  TACR12  TACR32  
    NPY1R2  NPFFR12  NPY2R2  HCRTR12  TACR22  
    15 SIMAP similar genes for QRFPR using alignment to 5 protein entries:     QRFPR_HUMAN (see all proteins):
    GHSR    DRD2    NPY2R    NPFFR2    SSTR5    GIR
    GALR1    NPY1R    NPY6R    GPR50    CXCR2    GPR18
    PPYR1    HCRTR1    TACR1

    QRFPR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for QRFPR
         9 CNVs: 98870 36195 37431 63943 37980 44128 92364 1098 32639
         3 Indels: 33770 80458 51232
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    QRFPR for disorders           About GeneDecksing

    OMIM gene information: 606925    OMIM disorders: --

    3 diseases for QRFPR:    About MalaCards
    vestibular neuronitis    neuronitis    thyroiditis


    Export disorders for QRFPR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for QRFPR gene integrated from 9 sources:
    (articles sorted by number of sources associating them with QRFPR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)1, 2, 3 Lee D.K....O'Dowd B.F. (2001)
    2. A new peptidic ligand and its receptor regulating adrenal function in rats. (PubMed id 12960173)1, 2, 9 Fukusumi S.... Fujino M. (2003)
    3. Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. (PubMed id 12714592)1, 2 Jiang Y.... Zhang F.L. (2003)
    4. GPR103b functions in the peripheral regulation of adi pogenesis. (PubMed id 20534693)1 Mulumba M....Ong H. (2010)
    5. A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. (PubMed id 16648250)1 Takayasu S....Sakai J. (2006)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Stable association between G alpha(q) and phospholipase C beta 1 in living cells. (PubMed id 16754659)1 Dowal L....Scarlata S. (2006)
    8. Analysis of phosphatase and tensin homolog tumor supp ressor interacting proteins by in vitro and in silico proteomics. (PubMed id 15717329)1 Crockett D.K....Lim M.S. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84109 HGNC: 15565 AceView: GPR103 Ensembl:ENSG00000186867 euGenes: HUgn84109
    ECgene: QRFPR H-InvDB: QRFPR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for QRFPR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for QRFPR gene:
    Search GeneIP for patents involving QRFPR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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     Regulatory tfbs in QRFPR promoter
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     Novus Tissue Slides
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     QRFPR Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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