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Aliases for QRFPR Gene

Aliases for QRFPR Gene

  • Pyroglutamylated RFamide Peptide Receptor 2 3
  • Orexigenic Neuropeptide QRFP Receptor 3 4
  • G Protein-Coupled Receptor 103 2 3
  • G-Protein Coupled Receptor 103 3 4
  • Peptide P518 Receptor 2 3
  • GPR103 3 4
  • SP9155 3 4
  • AQ27 3 4
  • QRFP Receptor 3

External Ids for QRFPR Gene

Previous HGNC Symbols for QRFPR Gene

  • GPR103

Previous GeneCards Identifiers for QRFPR Gene

  • GC04M122472
  • GC04M122249
  • GC04M117976

Summaries for QRFPR Gene

GeneCards Summary for QRFPR Gene

QRFPR (Pyroglutamylated RFamide Peptide Receptor) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for QRFPR Gene

  • Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.

Gene Wiki entry for QRFPR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRFPR Gene

Genomics for QRFPR Gene

Regulatory Elements for QRFPR Gene

Genomic Location for QRFPR Gene

121,328,642 bp from pter
121,381,059 bp from pter
52,418 bases
Minus strand

Genomic View for QRFPR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for QRFPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRFPR Gene

Proteins for QRFPR Gene

  • Protein details for QRFPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pyroglutamylated RFamide peptide receptor
    Protein Accession:
    Secondary Accessions:

    Protein attributes for QRFPR Gene

    431 amino acids
    Molecular mass:
    49488 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAL26488.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for QRFPR Gene

Proteomics data for QRFPR Gene at MOPED

Post-translational modifications for QRFPR Gene

  • Glycosylation at Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for QRFPR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for QRFPR Gene

Domains for QRFPR Gene

Gene Families for QRFPR Gene

  • RFAPR :GPCR / Class A : RF amide peptide receptors

Protein Domains for QRFPR Gene

Suggested Antigen Peptide Sequences for QRFPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96P65
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with QRFPR: view

Function for QRFPR Gene

Molecular function for QRFPR Gene

UniProtKB/Swiss-Prot Function: Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.

Gene Ontology (GO) - Molecular Function for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 12960173
GO:0004983 neuropeptide Y receptor activity IEA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with QRFPR: view

Phenotypes for QRFPR Gene

MGI mutant phenotypes for QRFPR:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with QRFPR: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for QRFPR Gene

Localization for QRFPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for QRFPR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for QRFPR Gene COMPARTMENTS Subcellular localization image for QRFPR gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IC 12960173
genes like me logo Genes that share ontologies with QRFPR: view

Pathways for QRFPR Gene

genes like me logo Genes that share pathways with QRFPR: view

Gene Ontology (GO) - Biological Process for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 12960173
GO:0007218 neuropeptide signaling pathway IEA --
GO:0032870 cellular response to hormone stimulus IBA --
GO:1901652 response to peptide IBA --
genes like me logo Genes that share ontologies with QRFPR: view

Compounds for QRFPR Gene

(1) HMDB Compounds for QRFPR Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(4) IUPHAR Ligand for QRFPR Gene

Ligand Type Action Affinity Pubmed IDs
[125I]QRFP (human) Agonist Full agonist 10.3
QRFP Agonist Full agonist 8.57
QRFP Agonist Full agonist 8.57
QRFP26 Agonist Full agonist 8.2
genes like me logo Genes that share compounds with QRFPR: view

Transcripts for QRFPR Gene

mRNA/cDNA for QRFPR Gene

(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for QRFPR Gene

Pyroglutamylated RFamide peptide receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QRFPR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -

Relevant External Links for QRFPR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for QRFPR Gene

mRNA expression in normal human tissues for QRFPR Gene

mRNA differential expression in normal tissues according to GTEx for QRFPR Gene

This gene is overexpressed in Brain - Hypothalamus (15.1), Heart - Left Ventricle (7.6), and Kidney - Cortex (4.6).

SOURCE GeneReport for Unigene cluster for QRFPR Gene Hs.368977

mRNA Expression by UniProt/SwissProt for QRFPR Gene

Tissue specificity: Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid.
genes like me logo Genes that share expressions with QRFPR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for QRFPR Gene

Orthologs for QRFPR Gene

This gene was present in the common ancestor of animals.

Orthologs for QRFPR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia QRFPR 35
  • 99.3 (n)
  • 98.14 (a)
  • 98 (a)
(Bos Taurus)
Mammalia QRFPR 35
  • 89.79 (n)
  • 91.42 (a)
  • 91 (a)
(Canis familiaris)
Mammalia QRFPR 35
  • 90.1 (n)
  • 90.95 (a)
  • 93 (a)
(Mus musculus)
Mammalia C130060K24Rik 36
  • 81 (a)
Qrfpr 35
  • 84.45 (n)
  • 83.53 (a)
Qrfpr 16
Qrfpr 36
  • 83 (a)
(Monodelphis domestica)
Mammalia QRFPR 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia QRFPR 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Qrfpr 35
  • 84.15 (n)
  • 83.99 (a)
(Gallus gallus)
Aves GPR103 36
  • 78 (a)
  • 77.41 (n)
  • 78.59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
-- 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia qrfpr 35
  • 75.04 (n)
  • 78.91 (a)
Str.17272 35
(Danio rerio)
Actinopterygii CABZ01084347.1 36
  • 63 (a)
LOC100149491 35
  • 65.41 (n)
  • 63.58 (a)
QRFPR (3 of 3) 36
  • 51 (a)
qrfpra 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta SIFR 36
  • 13 (a)
Species with no ortholog for QRFPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for QRFPR Gene

Gene Tree for QRFPR (if available)
Gene Tree for QRFPR (if available)

Paralogs for QRFPR Gene

Selected SIMAP similar genes for QRFPR Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with QRFPR: view

Variants for QRFPR Gene

Sequence variations from dbSNP and Humsavar for QRFPR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs506955 -- 121,375,804(+) GATAG(A/G)GACAT intron-variant
rs516449 -- 121,354,345(-) ATATG(C/T)CATGT intron-variant
rs520057 -- 121,364,459(-) CAGGG(G/T)TTCAC intron-variant
rs523815 -- 121,379,140(+) TTCAA(A/G)TCAAT intron-variant
rs527562 -- 121,379,547(+) ATCTC(A/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QRFPR Gene

Variant ID Type Subtype PubMed ID
nsv879859 CNV Gain 21882294
nsv4494 CNV Loss 18451855
nsv437422 CNV Loss 16327808
nsv508308 CNV Loss 20534489
nsv10559 CNV Loss 18304495
esv2533163 CNV Loss 19546169
esv2539204 CNV Deletion 19546169
dgv894n67 CNV Loss 20364138
esv2385732 CNV Deletion 18987734
esv2728254 CNV Deletion 23290073
esv25515 CNV Loss 19812545
nsv514249 CNV Loss 21397061
nsv499065 CNV Loss 21111241
dgv972e199 CNV Deletion 23128226
nsv442920 CNV CNV 18776908
esv2421795 CNV Deletion 20811451
nsv516414 CNV Loss 19592680
nsv528104 CNV Loss 19592680
esv1499673 CNV Deletion 17803354
nsv292673 CNV Loss 16902084
nsv10560 CNV Loss 18304495

Relevant External Links for QRFPR Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRFPR Gene

Disorders for QRFPR Gene

Relevant External Links for QRFPR

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with QRFPR: view

No data available for UniProtKB/Swiss-Prot for QRFPR Gene

Publications for QRFPR Gene

  1. A new peptidic ligand and its receptor regulating adrenal function in rats. (PMID: 12960173) Fukusumi S. … Fujino M. (J. Biol. Chem. 2003) 3 4 23
  2. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee D.K. … O'Dowd B.F. (Gene 2001) 2 3 4
  3. Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. (PMID: 12714592) Jiang Y. … Zhang F.L. (J. Biol. Chem. 2003) 3 4
  4. Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. (PMID: 15717329) Crockett D.K. … Lim M.S. (Proteomics 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for QRFPR Gene

Sources for QRFPR Gene

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