QRFPR Gene
protein-coding GIFtS: 54
GCID: GC04M122249
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pyroglutamylated RFamide peptide receptor(Previous name: G protein-coupled receptor 103 ) (Previous symbol: GPR103)
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Aliases for QRFPR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Pyroglutamylated RFamide Peptide Receptor1 2 | | AQ272 3 | | GPR1031 2 3 | | SP91552 3 | | G Protein-Coupled Receptor 1031 2 | | G-Protein Coupled Receptor 1032 3 | | Orexigenic Neuropeptide QRFP Receptor2 3 | | QRFP Receptor2 |
Export aliases for QRFPR gene to outside databasesPrevious GC identifers: GC04M122472 GC04M117976 |
Summaries for QRFPR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: QRFPR_HUMAN, Q96P65Function: Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins thatmodulate adenylate cyclase activity and intracellular calcium levels Gene Wiki entry for QRFPR (Pyroglutamylated RFamide peptide receptor)
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Genomic Views for QRFPR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the QRFPR gene promoter: GR LHX3b/Lhx3b GR-beta SREBP-1c POU6F1 (c2) SREBP-1b HEN1 SREBP-1a LHX3a/Lhx3a GR-alpha Other transcription factors
Search SABiosciences Chromatin IP Primers for QRFPR
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRFPR |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q27QRFPR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M122249: view genomic region
(about GC identifiers)
Start:
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122,249,797 bp from pter |
End:
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122,302,214 bp from pter |
Size:
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52,418 bases |
Orientation:
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minus strand |
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Proteins for QRFPR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: QRFPR_HUMAN, Q96P65 (See
protein sequence)Recommended Name: Pyroglutamylated RFamide peptide receptor Size: 431 amino acids; 49488 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAL26488.1; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for QRFPR: NX_Q96P65
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96P65 QRFPR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_937822.2 ENSEMBL proteins: ENSP00000423369 ENSP00000377948 ENSP00000335610 Reactome Protein details: Q96P65 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
QRFPR for ontologies About GeneDecksing
QRFPR Antibody Products: Assay Products for QRFPR: |
Protein
Domains / Families for QRFPR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
QRFPR for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96P65ProtoNet protein and cluster: Q96P65 1 Blocks protein family: IPB000611 Neuropeptide Y receptor signature
UniProtKB/Swiss-Prot: QRFPR_HUMAN, Q96P65Similarity: Belongs to the G-protein coupled receptor 1 family |
Function for QRFPR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: QRFPR_HUMAN, Q96P65Function: Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins thatmodulate adenylate cyclase activity and intracellular calcium levels
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRFPR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRFPR OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: QRFPR (NM_198179) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for QRFPR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRFPR  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRFPR |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IDA | 12960173 | | GO:0004983 | neuropeptide Y receptor activity |
IEA | -- |
QRFPR for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Qrfpr):
QRFPR for phenotypes About GeneDecksing
|
Pathways & Interactions for QRFPR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | |
Pathway sources See GeneCards unified pathways Show all pathways
5/9
Reactome Pathways for QRFPR (see all 9)
QRFPR for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QRFPR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/124 Interacting proteins for QRFPR (Q96P653 ENSP000003356104) via UniProtKB, MINT, STRING, and/or I2D (see all 124)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
IDA | 12960173 |
QRFPR for ontologies About GeneDecksing
|
Drugs & Compounds for QRFPR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for QRFPR
1 HMDB Compound for QRFPR About this table Search CenterWatch for drugs/clinical trials and news about QRFPR 
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Transcripts for QRFPR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for QRFPR gene: NM_198179.2 Unigene Cluster for QRFPR: Pyroglutamylated RFamide peptide receptor Hs.368977 [show with all ESTs]Unigene Representative Sequence: NM_1981794 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000507331 ENST00000394427(uc010inj.1 uc010ink.1 uc003ids.2) ENST00000334383 ENST00000512235(uc010inl.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRFPR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRFPR OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: QRFPR (NM_198179) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for QRFPR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRFPR  |
Additional cDNA sequence: AB109629.1 AK309337.1 BC128133.1 JF810892.1 4 DOTS entries: DT.92032599 DT.121227032 DT.92414713 DT.121227033 7 AceView cDNA sequences: AI378008 AI308124 AI307658 BG169612 NM_198179 AB109629 AF411117 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for QRFPR About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for QRFPR
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Expression for QRFPR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| QRFPR expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See QRFPR Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for QRFPR
SOURCE GeneReport for Unigene cluster: Hs.368977 UniProtKB/Swiss-Prot: QRFPR_HUMAN, Q96P65Tissue specificity: Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia andvestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus andmedulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart,kidney, testis and thyroid SABiosciences Expression via Pathway-Focused PCR Array including QRFPR:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for QRFPR Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat QRFPR | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QRFPR | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QRFPR | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRFPR |
Orthologs for QRFPR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for QRFPR gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for QRFPR (if available) TreeFam Gene Tree for QRFPR (if available)  |
Paralogs for QRFPR gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for QRFPR gene
- GPR832 HCRTR22 PRLHR2 NPFFR22 PPYR12 NPY5R2 TACR12 TACR32
- NPY1R2 NPFFR12 NPY2R2 HCRTR12 TACR22
15 SIMAP similar genes for QRFPR using alignment to 5 protein entries: QRFPR_HUMAN (see all proteins):GHSR DRD2 NPY2R NPFFR2 SSTR5 GIR GALR1 NPY1R NPY6R GPR50 CXCR2 GPR18 PPYR1 HCRTR1 TACR1
QRFPR for paralogs About GeneDecksing
|
Genomic Variants for QRFPR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 12 variations for QRFPR 9 CNVs: 98870 36195 37431 63943 37980 44128 92364 1098 32639 3 Indels: 33770 80458 51232 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QRFPR |
|
Disorders
/ Diseases for QRFPR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
QRFPR for disorders About GeneDecksing
OMIM gene information: 606925
OMIM disorders: --
3 diseases for QRFPR: About MalaCardsvestibular neuronitis neuronitis thyroiditis Export disorders for QRFPR gene to outside databases
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Publications for QRFPR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for QRFPR gene integrated from 9 sources: (articles sorted by number of sources associating them with QRFPR) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)1, 2, 3 Lee D.K....O'Dowd B.F. (2001)
- A new peptidic ligand and its receptor regulating adrenal function in rats. (PubMed id 12960173)1, 2, 9 Fukusumi S.... Fujino M. (2003)
- Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. (PubMed id 12714592)1, 2 Jiang Y.... Zhang F.L. (2003)
- GPR103b functions in the peripheral regulation of adi pogenesis. (PubMed id 20534693)1 Mulumba M....Ong H. (2010)
- A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. (PubMed id 16648250)1 Takayasu S....Sakai J. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Stable association between G alpha(q) and phospholipase C beta 1 in living cells. (PubMed id 16754659)1 Dowal L....Scarlata S. (2006)
- Analysis of phosphatase and tensin homolog tumor supp ressor interacting proteins by in vitro and in silico proteomics. (PubMed id 15717329)1 Crockett D.K....Lim M.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for QRFPR gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing QRFPR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing QRFPR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QRFPR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for QRFPR | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for QRFPR gene: Search GeneIP for patents involving QRFPR
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for QRFPR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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| | | | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for QRFPR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for QRFPR | | OriGene Protein Over-expression Lysate for QRFPR | | Browse OriGene Fluorogenic Cell Assay Kits | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for QRFPR | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QRFPR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QRFPR | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for QRFPR | | OriGene Custom Protein Services for QRFPR | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat QRFPR | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QRFPR | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRFPR | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QRFPR | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QRFPR | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QRFPR |
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| | | Search Tocris compounds for QRFPR |
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 | | QRFPR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRFPR |
|  |  |  | | | ThermoFisher Antibodies for QRFPR |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QRFPR |
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