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Aliases for QRFPR Gene

Aliases for QRFPR Gene

  • Pyroglutamylated RFamide Peptide Receptor 2 3 5
  • Orexigenic Neuropeptide QRFP Receptor 3 4
  • G Protein-Coupled Receptor 103 2 3
  • G-Protein Coupled Receptor 103 3 4
  • Peptide P518 Receptor 2 3
  • GPR103 3 4
  • SP9155 3 4
  • AQ27 3 4
  • QRFP Receptor 3

External Ids for QRFPR Gene

Previous HGNC Symbols for QRFPR Gene

  • GPR103

Previous GeneCards Identifiers for QRFPR Gene

  • GC04M122472
  • GC04M122249
  • GC04M117976

Summaries for QRFPR Gene

GeneCards Summary for QRFPR Gene

QRFPR (Pyroglutamylated RFamide Peptide Receptor) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot for QRFPR Gene

  • Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.

Gene Wiki entry for QRFPR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRFPR Gene

Genomics for QRFPR Gene

Regulatory Elements for QRFPR Gene

Enhancers for QRFPR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around QRFPR on UCSC Golden Path with GeneCards custom track

Promoters for QRFPR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around QRFPR on UCSC Golden Path with GeneCards custom track

Genomic Location for QRFPR Gene

Chromosome:
4
Start:
121,327,211 bp from pter
End:
121,381,059 bp from pter
Size:
53,849 bases
Orientation:
Minus strand

Genomic View for QRFPR Gene

Genes around QRFPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QRFPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QRFPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRFPR Gene

Proteins for QRFPR Gene

  • Protein details for QRFPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P65-QRFPR_HUMAN
    Recommended name:
    Pyroglutamylated RFamide peptide receptor
    Protein Accession:
    Q96P65

    Protein attributes for QRFPR Gene

    Size:
    431 amino acids
    Molecular mass:
    49488 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL26488.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for QRFPR Gene

Proteomics data for QRFPR Gene at MOPED

Post-translational modifications for QRFPR Gene

  • Glycosylation at Asn 19
  • Modification sites at PhosphoSitePlus

Other Protein References for QRFPR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for QRFPR Gene

Domains & Families for QRFPR Gene

Gene Families for QRFPR Gene

Protein Domains for QRFPR Gene

Suggested Antigen Peptide Sequences for QRFPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P65

UniProtKB/Swiss-Prot:

QRFPR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with QRFPR: view

Function for QRFPR Gene

Molecular function for QRFPR Gene

UniProtKB/Swiss-Prot Function:
Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.

Gene Ontology (GO) - Molecular Function for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with QRFPR: view
genes like me logo Genes that share phenotypes with QRFPR: view

Animal Models for QRFPR Gene

MGI Knock Outs for QRFPR:

Animal Model Products

  • Taconic Biosciences Mouse Models for QRFPR

CRISPR Products

miRNA for QRFPR Gene

miRTarBase miRNAs that target QRFPR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for QRFPR Gene

Localization for QRFPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for QRFPR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QRFPR Gene COMPARTMENTS Subcellular localization image for QRFPR gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with QRFPR: view

Pathways & Interactions for QRFPR Gene

genes like me logo Genes that share pathways with QRFPR: view

Gene Ontology (GO) - Biological Process for QRFPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032870 cellular response to hormone stimulus IBA --
genes like me logo Genes that share ontologies with QRFPR: view

No data available for SIGNOR curated interactions for QRFPR Gene

Drugs & Compounds for QRFPR Gene

(4) Drugs for QRFPR Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]QRFP (human) Pharma Full agonist, Agonist 0
QRFP Pharma Full agonist, Agonist 0
QRFP26 Pharma Full agonist, Agonist 0
calcium Nutra 0
genes like me logo Genes that share compounds with QRFPR: view

Transcripts for QRFPR Gene

mRNA/cDNA for QRFPR Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for QRFPR Gene

Pyroglutamylated RFamide peptide receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QRFPR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for QRFPR Gene

GeneLoc Exon Structure for
QRFPR
ECgene alternative splicing isoforms for
QRFPR

Expression for QRFPR Gene

mRNA expression in normal human tissues for QRFPR Gene

mRNA differential expression in normal tissues according to GTEx for QRFPR Gene

This gene is overexpressed in Brain - Hypothalamus (x15.1), Heart - Left Ventricle (x7.6), and Kidney - Cortex (x4.6).

SOURCE GeneReport for Unigene cluster for QRFPR Gene Hs.368977

mRNA Expression by UniProt/SwissProt for QRFPR Gene

Q96P65-QRFPR_HUMAN
Tissue specificity: Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid.
genes like me logo Genes that share expression patterns with QRFPR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for QRFPR Gene

Orthologs for QRFPR Gene

This gene was present in the common ancestor of animals.

Orthologs for QRFPR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia QRFPR 35
  • 89.79 (n)
  • 91.42 (a)
QRFPR 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QRFPR 35
  • 90.1 (n)
  • 90.95 (a)
QRFPR 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qrfpr 35
  • 84.45 (n)
  • 83.53 (a)
Qrfpr 16
C130060K24Rik 36
  • 81 (a)
OneToMany
Qrfpr 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia QRFPR 35
  • 99.3 (n)
  • 98.14 (a)
QRFPR 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Qrfpr 35
  • 84.15 (n)
  • 83.99 (a)
oppossum
(Monodelphis domestica)
Mammalia QRFPR 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QRFPR 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves QRFPR 35
  • 77.41 (n)
  • 78.59 (a)
GPR103 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia qrfpr 35
  • 75.04 (n)
  • 78.91 (a)
Str.17272 35
zebrafish
(Danio rerio)
Actinopterygii LOC100149491 35
  • 65.41 (n)
  • 63.58 (a)
CABZ01084347.1 36
  • 63 (a)
OneToMany
QRFPR (3 of 3) 36
  • 51 (a)
OneToMany
qrfpra 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta SIFR 36
  • 13 (a)
OneToMany
Species with no ortholog for QRFPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for QRFPR Gene

ENSEMBL:
Gene Tree for QRFPR (if available)
TreeFam:
Gene Tree for QRFPR (if available)

Paralogs for QRFPR Gene

genes like me logo Genes that share paralogs with QRFPR: view

Variants for QRFPR Gene

Sequence variations from dbSNP and Humsavar for QRFPR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs17438900 - 121,380,467(+) GCCAA(A/C)GAGCG reference, missense
rs11947418 - 121,340,504(+) AAAGG(A/C/G)TGCAC reference, missense, utr-variant-5-prime
rs2302310 - 121,329,579(-) TGTTT(A/C/T)GTCTG reference, missense
rs506955 -- 121,375,804(+) GATAG(A/G)GACAT intron-variant
rs516449 -- 121,354,345(-) ATATG(C/T)CATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QRFPR Gene

Variant ID Type Subtype PubMed ID
nsv879859 CNV Gain 21882294
nsv4494 CNV Loss 18451855
nsv437422 CNV Loss 16327808
nsv508308 CNV Loss 20534489
nsv10559 CNV Loss 18304495
esv2533163 CNV Loss 19546169
esv2539204 CNV Deletion 19546169
dgv894n67 CNV Loss 20364138
esv2385732 CNV Deletion 18987734
esv2728254 CNV Deletion 23290073
esv25515 CNV Loss 19812545
nsv514249 CNV Loss 21397061
nsv499065 CNV Loss 21111241
dgv972e199 CNV Deletion 23128226
nsv442920 CNV CNV 18776908
esv2421795 CNV Deletion 20811451
nsv516414 CNV Loss 19592680
nsv528104 CNV Loss 19592680
esv1499673 CNV Deletion 17803354
nsv292673 CNV Loss 16902084
nsv10560 CNV Loss 18304495

Variation tolerance for QRFPR Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.83; 94.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for QRFPR Gene

Disorders for QRFPR Gene

Relevant External Links for QRFPR

Genetic Association Database (GAD)
QRFPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QRFPR

No disorders were found for QRFPR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QRFPR Gene

Publications for QRFPR Gene

  1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee D.K. … O'Dowd B.F. (Gene 2001) 2 3 4 67
  2. A new peptidic ligand and its receptor regulating adrenal function in rats. (PMID: 12960173) Fukusumi S. … Fujino M. (J. Biol. Chem. 2003) 3 23
  3. GPR103b functions in the peripheral regulation of adipogenesis. (PMID: 20534693) Mulumba M. … Ong H. (Mol. Endocrinol. 2010) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. (PMID: 16648250) Takayasu S. … Sakai J. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3

Products for QRFPR Gene

Sources for QRFPR Gene

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