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Aliases &
Descriptions
for QRFP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| 26RFa 1, 2 | | MGC119794 2 | | OTTHUMP00000162441 2 | | P518 1, 2, 3 |
| | | Descriptions |
|---|
| P518 precursor protein 2 | | RF(Arg-Phe)amide family 26 amino acid peptide 2 | | RF(Arg-Phe)amide family 26 amino acid peptide (P518) 2 | | pyroglutamylated RFamide peptide 2 |
|
| |
Search outside databases for aliases for QRFP gene |
Summaries
for QRFP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for QRFP:
The P518 precursor protein can be processed into several RF (arg-phe)-amide peptides, including
P518. RF-amide peptides share a common C-terminal motif and are involved in cell signaling through
G protein-coupled receptors (Jiang et al., 2003 [PubMed 12714592]).[supplied by OMIM]
UniProtKB/Swiss-Prot: OX26_HUMAN, P83859Function: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood
pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By
similarity)Gene Wiki entry for QRFP |
Genomic Location
for QRFP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.12 Ensembl cytogenetic band: 9q34.12 HGNC cytogenetic band: 9q34.12QRFP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M132759:
(about GC identifiers)
Start:
|
132,758,636 bp from pter |
End:
|
132,759,046 bp from pter |
Size:
|
411 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_035014.4
| Proteins
for QRFP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OX26_HUMAN, P83859 (See
protein sequence)Recommended Name: Orexigenic neuropeptide QRFP precursor Size: 136 amino acids; 14941 Da
Subunit: Ligand for the G-protein coupled receptor QRFPR/GPR103 (By similarity)
Subcellular location: Secreted
Secondary accessions: A3KFJ6 Q495K6REFSEQ proteins: NP_937823.1
ENSEMBL proteins: ENSP00000345487
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
About this table
Antibodies for QRFP:
Assays for QRFP: | Protein
Domains/
Families
for QRFP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P83859 UniProtKB/Swiss-Prot: OX26_HUMAN, P83859Similarity: Belongs to the RFamide neuropeptide family | Gene Function
for QRFP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_198180
 Applied Biosystems Silencer® siRNAs for QRFP
 Sigma-Aldrich siRNA for QRFP
Sigma-Aldrich shRNA for QRFP
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_198180
Myc/DDK tagged cDNA clone in CMV expression vector: NM_198180
untagged cDNA clone in CMV expression vector: NM_198180
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_198180
UniProtKB/Swiss-Prot: OX26_HUMAN, P83859Function: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood
pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By
similarity)2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005184 | neuropeptide hormone activity |
IDA | 14657341 | | GO:0031854 | orexigenic neuropeptide QRFP receptor binding |
ISS | -- |
About this table | Pathways & Interactions
for QRFP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5 Interacting proteins for QRFP (ENSP000003454873) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds
for QRFP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for QRFP
1  Novoseek chemical compound relationship for QRFP gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rfamide |
88.01 |
6 |
14657341 (2), 16500002 (2) |
About this table
|
Transcripts
for QRFP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_198180
Sigma-Aldrich siRNA for QRFP
Sigma-Aldrich shRNA for QRFP
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_198180 REFSEQ mRNAs for QRFP gene: NM_198180.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_198180
OriGene GFP tagged cDNA clone in CMV expression vector: NM_198180
Myc/DDK tagged cDNA clone in CMV expression vector: NM_198180
untagged cDNA clone in CMV expression vector: NM_198180
Additional cDNA sequence: AB109625.1 BC101127.2 BC101128.1 XM_001714035.1 1 DOTS entry: DT.101977537 2 AceView cDNA sequences:NM_198180 AB109625 Unigene Cluster for QRFP: Pyroglutamylated RFamide peptide Hs.660704 [show with all ESTs]Unigene Representative Sequence: XM_001714035
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000343079
|
Expression
for QRFP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| QRFP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for QRFP
1 Data from GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.660704
UniProtKB/Swiss-Prot: OX26_HUMAN, P83859Tissue specificity: Expressed widely in the brain with highest expression levels in the cerebellum,
medulla, pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder,
colon, coronary artery, parathyroid gland, prostate, testis, and thyroid |
Orthologs
for QRFP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for QRFP gene from 5 species
About this table Species with no ortholog for QRFP
ENSEMBL Gene Tree for QRFP | Paralogs
for QRFP(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for QRFP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
The following additional 102 SNP(s) have been
found in Applied Biosystems data source:
(Click
for
Applied Biosystems TaqMan ® Genotyping Assay)
HapMap Linkage Disequilibrium images for QRFP (up to first 250kb)
|
Disorders & Mutations
for QRFP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609795
|
Medical News
for QRFP(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for QRFP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for QRFP gene (see all 13
):- Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. (PubMed id 12714592)2, 3, 4 Jiang Y.... Zhang F.L. (2003)
- Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. (PubMed id 14657341)1, 3, 4 Chartrel N.... Vaudry H. (2003)
- A new peptidic ligand and its receptor regulating adrenal function in rats. (PubMed id 12960173)1, 3, 4 Fukusumi S.... Fujino M. (2003)
- Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity. (PubMed id 15808908)2, 3 Thuau R....Vaudry H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord. (PubMed id 16899066)3 Bruzzone F....Chartrel N. (2006)
- Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals. (PubMed id 15891009)3 Chartrel N....Vaudry H. (2005)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)4 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP. (PubMed id 16500002)1 Fukusumi S....Hinuma S. (2006)
|
Search for QRFP
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing QRFP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing QRFP
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QRFP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for QRFP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for QRFP:
 | |
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| | |  | Search Tocris compounds for QRFP |
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