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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

QRFP Gene

protein-coding   GIFtS: 44
GCID: GC09M133768

Pyroglutamylated RFamide Peptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pyroglutamylated RFamide Peptide1 2     Orexigenic Neuropeptide QRFP2
prepro-QRFP1 2     P518 Precursor Protein2
P5182 3     RF(Arg-Phe)Amide Family 26 Amino Acid Peptide (P518)2
26RFa2     

External Ids:    HGNC: 299821   Entrez Gene: 3471482   Ensembl: ENSG000001887107   OMIM: 6097955   UniProtKB: P838593   

Export aliases for QRFP gene to outside databases

Previous GC identifers: GC09M132759 GC09M103255


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for QRFP Gene:
The P518 precursor protein can be processed into several RF (arg-phe)-amide peptides, including P518. RF-amide
peptides share a common C-terminal motif and are involved in cell signaling through G protein-coupled receptors
(Jiang et al., 2003 (PubMed 12714592)).(supplied by OMIM, Mar 2008)

GeneCards Summary for QRFP Gene: 
QRFP (pyroglutamylated RFamide peptide) is a protein-coding gene. Diseases associated with QRFP include anorexia nervosa, and thyroiditis, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include neuropeptide hormone activity and orexigenic neuropeptide QRFP receptor binding.

UniProtKB/Swiss-Prot: OX26_HUMAN, P83859
Function: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May
have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity)

Gene Wiki entry for QRFP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_035014.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the QRFP gene promoter:
         POU2F1a   SEF-1 (1)   Olf-1   AP-2gamma   MRF-2   LCR-F1   c-Ets-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQRFP promoter sequence
   Search SABiosciences Chromatin IP Primers for QRFP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QRFP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.12   Ensembl cytogenetic band:  9q34.12   HGNC cytogenetic band: 9q34.12

QRFP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QRFP gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M133768:  view genomic region     (about GC identifiers)

Start:
133,768,815 bp from pter      End:
133,769,225 bp from pter
Size:
411 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OX26_HUMAN, P83859 (See protein sequence)
Recommended Name: Orexigenic neuropeptide QRFP precursor  
Size: 136 amino acids; 14941 Da
Subunit: Ligand for the G-protein coupled receptor QRFPR/GPR103 (By similarity)
Subcellular location: Secreted
Secondary accessions: A3KFJ6 Q495K6

Explore the universe of human proteins at neXtProt for QRFP: NX_P83859

Explore proteomics data for QRFP at MOPED 

QRFP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

QRFP Protein Expression

REFSEQ proteins: NP_937823.1  
ENSEMBL proteins: 
 ENSP00000345487  
Reactome Protein details: P83859
Human Recombinant Protein Products for QRFP: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005576extracellular region TAS--

QRFP for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

1 InterPro protein domain:
 IPR024565 P518

Graphical View of Domain Structure for InterPro Entry P83859

ProtoNet protein and cluster: P83859

UniProtKB/Swiss-Prot: OX26_HUMAN, P83859
Similarity: Belongs to the RFamide neuropeptide family


QRFP for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: OX26_HUMAN, P83859
Function: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May
have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005184neuropeptide hormone activity IDA14657341
GO:0031854orexigenic neuropeptide QRFP receptor binding ISS--
     
QRFP for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for QRFP About                                                                                                See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
2Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
3G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
4Orexin and neuropeptides FF and QRFP bind to their respective receptors
Orexin and neuropeptides FF and QRFP bind to their respective receptors

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



5/9        Reactome Pathways for QRFP (see all 9)
    GPCR downstream signaling
Peptide ligand-binding receptors
Gastrin-CREB signalling pathway via PKC and MAPK
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Signaling by GPCR



QRFP for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QRFP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/123 Interacting proteins for QRFP (ENSP000003454874) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
InteractantInteraction Details
GeneCardExternal ID(s)
CCKENSP000003356574STRING: ENSP00000335657
CCKBRENSP000003355444STRING: ENSP00000335544
EDN1ENSP000003686834STRING: ENSP00000368683
GCGENSP000003876624STRING: ENSP00000387662
GNRH1ENSP000002764144STRING: ENSP00000276414
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007218neuropeptide signaling pathway IDA14657341
GO:0007625grooming behavior IEA--
GO:0007626locomotory behavior ISS--
GO:0045777positive regulation of blood pressure ISS--
GO:0060259regulation of feeding behavior ISS--

QRFP for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

QRFP for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for QRFP (OX26)

1 Novoseek inferred chemical compound relationship for QRFP gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
rfamide 87.4 6 14657341 (2), 16500002 (2)

Search CenterWatch for drugs/clinical trials and news about QRFP / OX26

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for QRFP gene: 
NM_198180.1  

Unigene Cluster for QRFP:

Pyroglutamylated RFamide peptide
Hs.660704  [show with all ESTs]
Unigene Representative Sequence: CV575364
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000343079(uc011mcb.2)
miRNA
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                     Customized lentivirus expression plasmids for stable overexpression of QRFP 
Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QRFP

Additional mRNA sequence: 

AB109625.1 BC101127.2 BC101128.1 

1 DOTS entry:

DT.101977537 

2 AceView cDNA sequences:

AB109625 NM_198180 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

QRFP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
QRFP Expression
About this image


See QRFP Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.660704

UniProtKB/Swiss-Prot: OX26_HUMAN, P83859
Tissue specificity: Expressed widely in the brain with highest expression levels in the cerebellum, medulla,
pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery,
parathyroid gland, prostate, testis, and thyroid

    SABiosciences Custom PCR Arrays for QRFP
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QRFP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for QRFP gene from 1/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Qrfp1 , 5 pyroglutamylated RFamide peptide1, 5 71.51(n)1
66.13(a)1
  2 (21.89 cM)5
2277171  NM_183424.31  NP_906269.11 
 318061665 


ENSEMBL Gene Tree for QRFP (if available)
TreeFam Gene Tree for QRFP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/109 SNPs in QRFP are shown (see all 109)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1426251931,2
--133768400(+) TTTGCA/CCTCTG 1 -- ds50010--------
rs727650881,2
C,F--133768415(+) CAGCCG/ACAGTC 1 -- ds50012Minor allele frequency- A:0.03NA 122
rs1866203711,2
--133768420(+) GCAGTC/TGTGCC 1 -- ds50010--------
rs1914220151,2
--133768473(+) CAGCCC/TGCTGC 1 -- ds50010--------
rs1836973031,2
--133768537(+) TGGGGA/CCAGGG 1 -- ds50010--------
rs801271381,2
C,F--133768634(+) TTTTCG/ACTTCA 1 -- ds50011Minor allele frequency- A:0.10WA 118
rs795817271,2
F--133768676(+) CTAACC/TTGTCC 1 -- ds50011Minor allele frequency- T:0.01WA 118
rs70297481,2
C,F,A--133768727(+) GGTGTC/GGTGGT 1 -- ds50015Minor allele frequency- G:0.17CSA WA NA 246
rs1460281791,2
--133768758(+) GCAGGA/TGTGAA 1 -- ds50010--------
rs1887341751,2
C--133768791(+) AGCAAA/GTCCTT 1 -- ds50011Minor allele frequency- G:0.00EU 893

HapMap Linkage Disequilibrium report for QRFP (133768815 - 133769225 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for QRFP:    About this table     
Variant IDTypeSubtypePubMed ID
dgv8306n71CNV Loss21882294
dgv8307n71CNV Loss21882294
nsv893963CNV Loss21882294
nsv6735CNV Loss18451855
nsv469903CNV Loss18288195
nsv893966CNV Gain21882294
nsv893960CNV Gain21882294
dgv2423e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 609795    OMIM disorders: --

3 diseases for QRFP:    About MalaCards
anorexia nervosa    thyroiditis    prostatitis


QRFP for disorders           About GeneDecksing


Export disorders for QRFP gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for QRFP gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with QRFP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. (PubMed id 12714592)1, 2, 3 Jiang Y.... Zhang F.L. (2003)
  2. Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. (PubMed id 14657341)1, 2, 9 Chartrel N.... Vaudry H. (2003)
  3. A new peptidic ligand and its receptor regulating adrenal function in rats. (PubMed id 12960173)1, 2, 9 Fukusumi S.... Fujino M. (2003)
  4. Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity. (PubMed id 15808908)1, 3 Thuau R....Vaudry H. (2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. The neuropeptide 26RFa is expressed in human prostate cancer and stimulates the neuroendocrine differentiation and the migration of an drogeno-independent prostate cancer cells. (PubMed id 22863147)1 Alonzeau J....Chartrel N. (2013)
  7. Orexigenic neuropeptide 26RFa: new evidence for an ada ptive profile of appetite regulation in anorexia nervosa. (PubMed id 22466335)1 Galusca B....Chartrel N. (2012)
  8. GPR103b functions in the peripheral regulation of adi pogenesis. (PubMed id 20534693)1 Mulumba M....Ong H. (2010)
  9. Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord. (PubMed id 16899066)1 Bruzzone F....Chartrel N. (2006)
  10. Stable association between G alpha(q) and phospholipase C beta 1 in living cells. (PubMed id 16754659)1 Dowal L....Scarlata S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 347148 HGNC: 29982 AceView: P518 Ensembl:ENSG00000188710 euGenes: HUgn347148
ECgene: QRFP H-InvDB: QRFP

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for QRFP Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for QRFP gene:
Search GeneIP for patents involving QRFP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for QRFP
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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