Free for academic non-profit institutions. Other users need a Commercial license

Aliases for QRFP Gene

Aliases for QRFP Gene

  • Pyroglutamylated RFamide Peptide 2 3 5
  • Prepro-QRFP 2 3
  • P518 3 4
  • RF(Arg-Phe)Amide Family 26 Amino Acid Peptide (P518) 3
  • P518 Precursor Protein 3
  • 26RFa 3

External Ids for QRFP Gene

Previous GeneCards Identifiers for QRFP Gene

  • GC09M132759
  • GC09M133768
  • GC09M103255

Summaries for QRFP Gene

Entrez Gene Summary for QRFP Gene

  • This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]

GeneCards Summary for QRFP Gene

QRFP (Pyroglutamylated RFamide Peptide) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include neuropeptide hormone activity and orexigenic neuropeptide QRFP receptor binding.

UniProtKB/Swiss-Prot for QRFP Gene

  • Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity).

Gene Wiki entry for QRFP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRFP Gene

Genomics for QRFP Gene

Regulatory Elements for QRFP Gene

Enhancers for QRFP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around QRFP on UCSC Golden Path with GeneCards custom track

Genomic Location for QRFP Gene

Chromosome:
9
Start:
130,892,702 bp from pter
End:
130,896,812 bp from pter
Size:
4,111 bases
Orientation:
Minus strand

Genomic View for QRFP Gene

Genes around QRFP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QRFP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QRFP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRFP Gene

Proteins for QRFP Gene

  • Protein details for QRFP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P83859-OX26_HUMAN
    Recommended name:
    Orexigenic neuropeptide QRFP
    Protein Accession:
    P83859
    Secondary Accessions:
    • A3KFJ6
    • Q495K6

    Protein attributes for QRFP Gene

    Size:
    136 amino acids
    Molecular mass:
    14941 Da
    Quaternary structure:
    • Ligand for the G-protein coupled receptor QRFPR/GPR103.

neXtProt entry for QRFP Gene

Proteomics data for QRFP Gene at MOPED

Post-translational modifications for QRFP Gene

No Post-translational modifications

Other Protein References for QRFP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for QRFP Gene

Domains & Families for QRFP Gene

Gene Families for QRFP Gene

Protein Domains for QRFP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for QRFP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P83859

UniProtKB/Swiss-Prot:

OX26_HUMAN :
  • Belongs to the RFamide neuropeptide family.
Family:
  • Belongs to the RFamide neuropeptide family.
genes like me logo Genes that share domains with QRFP: view

Function for QRFP Gene

Molecular function for QRFP Gene

UniProtKB/Swiss-Prot Function:
Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity).

Gene Ontology (GO) - Molecular Function for QRFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031854 orexigenic neuropeptide QRFP receptor binding IEA,ISS --
genes like me logo Genes that share ontologies with QRFP: view

Phenotypes for QRFP Gene

genes like me logo Genes that share phenotypes with QRFP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for QRFP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for QRFP Gene

Localization for QRFP Gene

Subcellular locations from UniProtKB/Swiss-Prot for QRFP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QRFP Gene COMPARTMENTS Subcellular localization image for QRFP gene
Compartment Confidence
extracellular 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for QRFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with QRFP: view

Pathways & Interactions for QRFP Gene

genes like me logo Genes that share pathways with QRFP: view

Interacting Proteins for QRFP Gene

Gene Ontology (GO) - Biological Process for QRFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IDA 14657341
GO:0045777 positive regulation of blood pressure ISS --
GO:0060259 regulation of feeding behavior ISS --
genes like me logo Genes that share ontologies with QRFP: view

No data available for SIGNOR curated interactions for QRFP Gene

Drugs & Compounds for QRFP Gene

(1) Additional Compounds for QRFP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with QRFP: view

Transcripts for QRFP Gene

mRNA/cDNA for QRFP Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for QRFP Gene

Pyroglutamylated RFamide peptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QRFP Gene

No ASD Table

Relevant External Links for QRFP Gene

GeneLoc Exon Structure for
QRFP
ECgene alternative splicing isoforms for
QRFP

Expression for QRFP Gene

mRNA expression in normal human tissues for QRFP Gene

mRNA differential expression in normal tissues according to GTEx for QRFP Gene

This gene is overexpressed in Colon - Sigmoid (x4.1).

SOURCE GeneReport for Unigene cluster for QRFP Gene Hs.660704

mRNA Expression by UniProt/SwissProt for QRFP Gene

P83859-OX26_HUMAN
Tissue specificity: Expressed widely in the brain with highest expression levels in the cerebellum, medulla, pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery, parathyroid gland, prostate, testis, and thyroid.
genes like me logo Genes that share expression patterns with QRFP: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for QRFP Gene

Orthologs for QRFP Gene

This gene was present in the common ancestor of mammals.

Orthologs for QRFP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia QRFP 35
  • 74.88 (n)
  • 64.18 (a)
QRFP 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QRFP 35
  • 77.45 (n)
  • 66.91 (a)
QRFP 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qrfp 35
  • 72.88 (n)
  • 68.64 (a)
Qrfp 16
Qrfp 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia QRFP 35
  • 98.28 (n)
  • 98.53 (a)
QRFP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Qrfp 35
  • 75.07 (n)
  • 67.83 (a)
oppossum
(Monodelphis domestica)
Mammalia QRFP 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QRFP 36
  • 47 (a)
OneToOne
Species with no ortholog for QRFP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for QRFP Gene

ENSEMBL:
Gene Tree for QRFP (if available)
TreeFam:
Gene Tree for QRFP (if available)

Paralogs for QRFP Gene

No data available for Paralogs for QRFP Gene

Variants for QRFP Gene

Sequence variations from dbSNP and Humsavar for QRFP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs12340616 - 130,893,636(+) TGACA(A/T)GCAGG reference, missense
rs7853654 -- 130,894,883(+) TTTTT(A/G)ACAAT intron-variant
rs7858551 -- 130,896,517(+) CCACT(C/G)TCAGG intron-variant
rs7865017 -- 130,894,835(+) ATGAA(C/T)CTGCC intron-variant
rs113532932 -- 130,895,403(+) ATCTG(C/G)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QRFP Gene

Variant ID Type Subtype PubMed ID
dgv2423e1 CNV Complex 17122850
nsv6735 CNV Loss 18451855
nsv893960 CNV Gain 21882294
dgv8306n71 CNV Loss 21882294
dgv8307n71 CNV Loss 21882294
nsv893963 CNV Loss 21882294
nsv469903 CNV Loss 18288195
nsv893966 CNV Gain 21882294

Variation tolerance for QRFP Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for QRFP Gene

HapMap Linkage Disequilibrium report
QRFP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRFP Gene

Disorders for QRFP Gene

Relevant External Links for QRFP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QRFP

No disorders were found for QRFP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QRFP Gene

Publications for QRFP Gene

  1. Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. (PMID: 12714592) Jiang Y. … Zhang F.L. (J. Biol. Chem. 2003) 2 3 4 67
  2. Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP. (PMID: 16500002) Fukusumi S. … Hinuma S. (Peptides 2006) 3 23
  3. Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity. (PMID: 15808908) Thuau R. … Vaudry H. (Peptides 2005) 2 3
  4. A new peptidic ligand and its receptor regulating adrenal function in rats. (PMID: 12960173) Fukusumi S. … Fujino M. (J. Biol. Chem. 2003) 3 23
  5. Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. (PMID: 14657341) Chartrel N. … Vaudry H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 23

Products for QRFP Gene

Sources for QRFP Gene

Content