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Aliases for QRFP Gene

Aliases for QRFP Gene

  • Pyroglutamylated RFamide Peptide 2 3
  • P518 3 4 6
  • Prepro-QRFP 2 3
  • 26RFa 3 6
  • RF(Arg-Phe)Amide Family 26 Amino Acid Peptide (P518) 3
  • Orexigenic Neuropeptide QRFP 3
  • P518 Precursor Protein 3

External Ids for QRFP Gene

Previous GeneCards Identifiers for QRFP Gene

  • GC09M132759
  • GC09M133768
  • GC09M103255

Summaries for QRFP Gene

Entrez Gene Summary for QRFP Gene

  • The P518 precursor protein can be processed into several RF (arg-phe)-amide peptides, including P518. RF-amide peptides share a common C-terminal motif and are involved in cell signaling through G protein-coupled receptors (Jiang et al., 2003 [PubMed 12714592]).[supplied by OMIM, Mar 2008]

GeneCards Summary for QRFP Gene

QRFP (Pyroglutamylated RFamide Peptide) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide hormone activity and orexigenic neuropeptide QRFP receptor binding.

UniProtKB/Swiss-Prot for QRFP Gene

  • Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity).

Gene Wiki entry for QRFP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QRFP Gene

Genomics for QRFP Gene

Regulatory Elements for QRFP Gene

Genomic Location for QRFP Gene

130,892,702 bp from pter
130,896,812 bp from pter
4,111 bases
Minus strand

Genomic View for QRFP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for QRFP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QRFP Gene

Proteins for QRFP Gene

  • Protein details for QRFP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Orexigenic neuropeptide QRFP
    Protein Accession:
    Secondary Accessions:
    • A3KFJ6
    • Q495K6

    Protein attributes for QRFP Gene

    136 amino acids
    Molecular mass:
    14941 Da
    Quaternary structure:
    • Ligand for the G-protein coupled receptor QRFPR/GPR103.

neXtProt entry for QRFP Gene

Proteomics data for QRFP Gene at MOPED

Post-translational modifications for QRFP Gene

No Post-translational modifications

Other Protein References for QRFP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for QRFP Gene

Domains for QRFP Gene

Gene Families for QRFP Gene


Protein Domains for QRFP Gene


Suggested Antigen Peptide Sequences for QRFP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P83859
  • Belongs to the RFamide neuropeptide family.
genes like me logo Genes that share domains with QRFP: view

Function for QRFP Gene

Molecular function for QRFP Gene

UniProtKB/Swiss-Prot Function: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity).

Gene Ontology (GO) - Molecular Function for QRFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005184 neuropeptide hormone activity IDA 14657341
GO:0031854 orexigenic neuropeptide QRFP receptor binding ISS --
genes like me logo Genes that share ontologies with QRFP: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for QRFP Gene

Localization for QRFP Gene

Subcellular locations from UniProtKB/Swiss-Prot for QRFP Gene


Subcellular locations from

Jensen Localization Image for QRFP Gene COMPARTMENTS Subcellular localization image for QRFP gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for QRFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with QRFP: view

Pathways for QRFP Gene

genes like me logo Genes that share pathways with QRFP: view

Interacting Proteins for QRFP Gene

Gene Ontology (GO) - Biological Process for QRFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IDA 14657341
GO:0007625 grooming behavior IEA --
GO:0007626 locomotory behavior ISS --
GO:0045777 positive regulation of blood pressure ISS --
GO:0060259 regulation of feeding behavior ISS --
genes like me logo Genes that share ontologies with QRFP: view

Compounds for QRFP Gene

(1) Novoseek inferred chemical compound relationships for QRFP Gene

Compound -log(P) Hits PubMed IDs
rfamide 87.4 4
genes like me logo Genes that share compounds with QRFP: view

Transcripts for QRFP Gene

mRNA/cDNA for QRFP Gene

(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for QRFP Gene

Pyroglutamylated RFamide peptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QRFP Gene

No ASD Table

Relevant External Links for QRFP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for QRFP Gene

mRNA expression in normal human tissues for QRFP Gene

mRNA differential expression in normal tissues according to GTEx for QRFP Gene

This gene is overexpressed in Colon - Sigmoid (4.1).

SOURCE GeneReport for Unigene cluster for QRFP Gene Hs.660704

mRNA Expression by UniProt/SwissProt for QRFP Gene

Tissue specificity: Expressed widely in the brain with highest expression levels in the cerebellum, medulla, pituitary, retina, vestibular nucleus, and white matter. Also expressed in the bladder, colon, coronary artery, parathyroid gland, prostate, testis, and thyroid.
genes like me logo Genes that share expressions with QRFP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for QRFP Gene

Orthologs for QRFP Gene

This gene was present in the common ancestor of mammals.

Orthologs for QRFP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia QRFP 35
  • 98.28 (n)
  • 98.53 (a)
  • 99 (a)
(Bos Taurus)
Mammalia QRFP 35
  • 74.88 (n)
  • 64.18 (a)
  • 62 (a)
(Canis familiaris)
Mammalia QRFP 35
  • 77.45 (n)
  • 66.91 (a)
  • 66 (a)
(Mus musculus)
Mammalia Qrfp 35
  • 72.88 (n)
  • 68.64 (a)
Qrfp 16
Qrfp 36
  • 68 (a)
(Monodelphis domestica)
Mammalia QRFP 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia QRFP 36
  • 47 (a)
(Rattus norvegicus)
Mammalia Qrfp 35
  • 75.07 (n)
  • 67.83 (a)
Species with no ortholog for QRFP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for QRFP Gene

Gene Tree for QRFP (if available)
Gene Tree for QRFP (if available)

Paralogs for QRFP Gene

No data available for Paralogs for QRFP Gene

Variants for QRFP Gene

Sequence variations from dbSNP and Humsavar for QRFP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3847193 -- 130,893,782(-) TGCTT(C/T)CCTCT reference, synonymous-codon
rs7029748 -- 130,893,340(+) GGTGT(C/G)GTGGT downstream-variant-500B
rs7034278 -- 130,894,399(+) GGGGC(C/T)TGGGC upstream-variant-2KB
rs7040543 -- 130,894,630(+) TAGGT(A/C)CTCCC upstream-variant-2KB
rs7044590 -- 130,895,416(+) TGGGG(A/G)TGCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for QRFP Gene

Variant ID Type Subtype PubMed ID
dgv2423e1 CNV Complex 17122850
nsv6735 CNV Loss 18451855
nsv893960 CNV Gain 21882294
dgv8306n71 CNV Loss 21882294
dgv8307n71 CNV Loss 21882294
nsv893963 CNV Loss 21882294
nsv469903 CNV Loss 18288195
nsv893966 CNV Gain 21882294

Relevant External Links for QRFP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QRFP Gene

Disorders for QRFP Gene

No disorders were found for QRFP Gene.

No data available for UniProtKB/Swiss-Prot for QRFP Gene

Publications for QRFP Gene

  1. Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. (PMID: 12714592) Jiang Y. … Zhang F.L. (J. Biol. Chem. 2003) 2 3 4
  2. A new peptidic ligand and its receptor regulating adrenal function in rats. (PMID: 12960173) Fukusumi S. … Fujino M. (J. Biol. Chem. 2003) 3 4 23
  3. Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. (PMID: 14657341) Chartrel N. … Vaudry H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity. (PMID: 15808908) Thuau R. … Vaudry H. (Peptides 2005) 2 3

Products for QRFP Gene

Sources for QRFP Gene

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