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Aliases & Descriptions for QPRT
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.4.2.19 3 | | QAPRTase 3 | | QPRTase 1, 2, 3 |
| | | Descriptions |
|---|
| Quinolinate phosphoribosyltransferase [decarboxylating] 3 | | nicotinate-nucleotide pyrophosphorylase (carboxylating) 2 | | quinolinate phosphoribosyltransferase 2 |
|
| | Search outside databases for aliases for QPRT genePrevious GC identifers: GC16M028713 GC16P030014 GC16P029688 GC16P029728 |
Summaries for QPRT(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for QPRT: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq]
|
Genomic Location for QPRT
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the QPRT gene 
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2QPRT Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P029597:
(about GC identifiers)
Start:
|
29,597,938 bp from pter |
End:
|
29,616,816 bp from pter |
Size:
|
18,879 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010393.15
| Proteins for QPRT
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274 (See
protein sequence)Recommended Name: Nicotinate-nucleotide pyrophosphorylase [carboxylating] Size: 297 amino acids; 30816 Da
PDB structures from and Proteopedia :2JBM (3D)
 
Secondary accessions: Q53XW7 Q96G22 Q9BSG6Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055113.2
ENSEMBL proteins: ENSP00000378782 ENSP00000219771
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for QPRT: Assays for QPRT: | Protein
Domains/ Families for QPRT(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q15274
ProtoNet protein and cluster: Q15274 1 Blocks protein family: IPB002638 Quinolinate phosphoribosyl transferase
UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274Similarity: Belongs to the nadC/modD family | Gene Function for QPRT
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014298
Applied Biosystems Silencer® siRNAs for QPRT
Sigma-Aldrich siRNA for QPRT  Sigma-Aldrich shRNA for QPRT  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014298                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014298                                  untagged cDNA clones in CMV expression vector (see all 2): NM_014298 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014298
UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274Catalytic activity: Nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphateEnzyme Number (IUBMB): EC 2.4.2.19 3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for QPRT
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for QPRT (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate ribonucleotide from pyridine-2,3-dicarboxylate: step 1/1 5/19 Interacting proteins for QPRT (ENSP000002197713) via UniProtKB, MINT, and/or STRING (see all 19
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for QPRT(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for QPRT 2 Novoseek chemical compound relationships for QPRT gene
About this table
|
Transcripts for QPRT(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014298
Sigma-Aldrich siRNA for QPRT  Sigma-Aldrich shRNA for QPRT  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014298 REFSEQ mRNAs for QPRT gene: NM_014298.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014298               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014298                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014298                                  untagged cDNA clones in CMV expression vector (see all 2): NM_014298  Additional cDNA sequence: AK293195.1 BC005060.1 BC010033.2 BC018910.2 BT007231.1 CR594408.1 CR595386.1 CR600977.1 CR603957.1 CR608816.1 D78177.1 13 DOTS entries: DT.120696423 DT.414520 DT.120696998 DT.95137093 DT.100784782 DT.100659515 DT.100784778 DT.120696260 DT.95082378 DT.100009582 DT.120695401 DT.455060 DT.92430926 24/264 AceView cDNA sequences (see all 264
):J04536 AA337770 BU501515 BC018910 AW293885 NM_014298 AA343173 AI383718 BM471758 CR601465 CR595386 CR600977 BX104943 AW059610 BC012350 BI870607 AL531128 CR603957 BX283118 BI822033 AW263079 BM711970 BC010033 BG820380
highest scoring ESTs for QPRT:D78177 AA070788 AA070899 AA252289 AA305670 AA411504 AA477534 AA479051 AA548874 AA627205 Unigene Cluster for QPRT: Quinolinate phosphoribosyltransferase Hs.513484 [show with all ESTs]Unigene Representative Sequence: NM_014298
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for QPRT
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for QPRT
2 Ensembl transcripts including schematic representations: ENST00000395384
ENST00000219771
|
Expression for QPRT
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| QPRT expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for QPRT
1 / 2 / 3 3 probe-sets matching QPRT gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGTTAACGTG
SOURCE GeneReport for Unigene cluster: Hs.513484
Expression variation in blood from EXPOLDB for QPRT |
Orthologs for QPRT
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for QPRT gene from 5/11 species (see all 11
)
About this table Species with no ortholog for QPRT
ENSEMBL Gene Tree for QPRT | Paralogs for QPRT(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for QPRT(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for QPRT (up to first 250kb)
|
Disorders & Mutations for QPRT
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606248
1 PharmGKB disease relationship for QPRT geneAbout this table
|
Medical News for QPRT(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for QPRT (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for QPRT gene (see all 18
):- Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. (PubMed id 9473669)1, 2, 3, 4 Fukuoka S.... Shibata K. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. (PubMed id 17868694)1, 3 Liu H....Naismith J.H. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
- Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. (PubMed id 12086872)7 Yeoh E.J....Downing J.R. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. (PubMed id 10721107)3 Fukuoka S. and Shibata K. (1999)
- Quinolinic-phosphoribosyl transferase activity is decreased in epileptic human brain tissue. (PubMed id 3409840)3 Feldblum S....Lloyd K.G. (1988)
- QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study. (PubMed id 19321014)1 Hinsch N....Hansmann M.L. (2009)
- Reversed-phase high-performance liquid chromatography of nicotinic acid mononucleotide for measurement of quinolinate phosphoribosyltransferase. (PubMed id 11145065)1 Shibata K....Sugimoto E. (2000)
|
Search for QPRT
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing QPRT
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing QPRT
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QPRT(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for QPRT(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for QPRT:

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Incremental update: 13 Oct 2009
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