Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

QPRT Gene

protein-coding   GIFtS: 65
GCID: GC16P029690

Quinolinate Phosphoribosyltransferase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Quinolinate Phosphoribosyltransferase1 2     EC 2.4.2.193 8
Nicotinate-Nucleotide Pyrophosphorylase (Carboxylating)1 2     Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]2
QAPRTase2 3     Quinolinate Phosphoribosyltransferase [Decarboxylating]3
QPRTase2 3     

External Ids:    HGNC: 97551   Entrez Gene: 234752   Ensembl: ENSG000001034857   OMIM: 6062485   UniProtKB: Q152743   

Export aliases for QPRT gene to outside databases

Previous GC identifers: GC16M028713 GC16P030014 GC16P029688 GC16P029728 GC16P029597 GC16P027351 GC16P029675


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for QPRT Gene:
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide
adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of
quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as
epilepsy, Alzheimer's disease, and Huntington's disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for QPRT Gene: 
QPRT (quinolinate phosphoribosyltransferase) is a protein-coding gene. Diseases associated with QPRT include pellagra, and seizure disorder, and among its related super-pathways are Nicotinate metabolism and NAD metabolism. GO annotations related to this gene include nicotinate-nucleotide diphosphorylase (carboxylating) activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274
Function: Involved in the catabolism of quinolinic acid (QA)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the QPRT gene promoter:
         Egr-2   FOXI1   HFH-3   p53   XBP-1   MIF-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQPRT promoter sequence
   Search SABiosciences Chromatin IP Primers for QPRT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QPRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

QPRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QPRT gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029690:  view genomic region     (about GC identifiers)

Start:
29,690,329 bp from pter      End:
29,710,020 bp from pter
Size:
19,692 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274 (See protein sequence)
Recommended Name: Nicotinate-nucleotide pyrophosphorylase [carboxylating]  
Size: 297 amino acids; 30846 Da
Subunit: Hexamer formed by 3 homodimers
2 PDB 3D structures from and Proteopedia for QPRT:
2JBM (3D)        3LAR (3D)    
Secondary accessions: Q53XW7 Q96G22 Q9BSG6

Explore the universe of human proteins at neXtProt for QPRT: NX_Q15274

Explore proteomics data for QPRT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15274

  • 3 DME Specific Peptides for QPRT (Q15274)
     TRKTTPG  LKVEVECSSL  LWAKSPGVLAG 

    QPRT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    QPRT Protein Expression
    REFSEQ proteins: NP_055113.2  
    ENSEMBL proteins: 
     ENSP00000378782   ENSP00000455183  
    Reactome Protein details: Q15274
    Human Recombinant Protein Products for QPRT: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for QPRT
    OriGene Protein Over-expression Lysate for QPRT
    OriGene MassSpec for QPRT 
    OriGene Custom Protein Services for QPRT
    GenScript Custom Purified and Recombinant Proteins Services for QPRT
    Novus Biologicals QPRT Proteins
    Novus Biologicals QPRT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for QPRT
    Cloud-Clone Corp. Proteins for QPRT 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    QPRT for ontologies           About GeneDecksing



    QPRT Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for QPRT
    OriGene Custom Antibody Services for QPRT
    GenScript Custom Superior Antibodies Services for QPRT
    Novus Biologicals QPRT Antibodies
    Abcam antibodies for QPRT
    Cloud-Clone Corp. Antibodies for QPRT 
    ThermoFisher Antibodies for QPRT
    LSBio Antibodies in human, mouse, rat for QPRT 

    Assay Products for QPRT: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for QPRT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for QPRT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for QPRT 
    Cloud-Clone Corp. CLIAs for QPRT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR004393 NadC
     IPR002638 Quinolinate_PRibosylTrfase_C
     IPR027277 NadC/ModD
     IPR022412 Quinolinate_PRibosylTrfase_N

    Graphical View of Domain Structure for InterPro Entry Q15274

    ProtoNet protein and cluster: Q15274

    1 Blocks protein domain: IPB002638 Quinolinate phosphoribosyl transferase

    UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274
    Similarity: Belongs to the NadC/ModD family


    QPRT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NADC_HUMAN, Q15274
    Function: Involved in the catabolism of quinolinic acid (QA)
    Catalytic activity: Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate +
    5-phospho-alpha-D-ribose 1-diphosphate
    Enzyme regulation: Activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a
    competitive and a non-competitive manner
    Biophysicochemical properties: Kinetic parameters: KM=21 uM for QA (at 0.1 mM PRPP); KM=23 uM for QA (at 0.3 mM
    PRPP); Vmax=1.2 uM/min/mg enzyme (at 0.3 mM QA and 0.1 mM PRPP); Vmax=0.93 uM/min/mg enzyme (at 0.3 mM QA and 0.3
    mM PRPP);

         Enzyme Number (IUBMB): EC 2.4.2.191 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004514nicotinate-nucleotide diphosphorylase (carboxylating) activity IDA17868694
    GO:0016763transferase activity, transferring pentosyl groups ----
    GO:0042803protein homodimerization activity IDA17868694
         
    QPRT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for QPRT:
     Decreased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for QPRT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for QPRT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for QPRT 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for QPRT 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat QPRT
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate QPRT:
    hsa-miR-588 hsa-miR-4252
    SwitchGear 3'UTR luciferase reporter plasmidQPRT 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for QPRT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QPRT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for QPRT
    Sirion Biotech Customized adenovirus for overexpression of QPRT

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for QPRT (see all 8)
    OriGene ORF clones in mouse, rat for QPRT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: QPRT (NM_014298)
    Sino Biological Human cDNA Clone for QPRT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for QPRT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QPRT
    Sirion Biotech Customized lentivirus for stable overexpression of QPRT 
                         Customized lentivirus expression plasmids for stable overexpression of QPRT 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for QPRT
    Search LifeMap BioReagents cell lines for QPRT
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QPRT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for QPRT About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nicotinate metabolism
    Nicotinate metabolism0.62
    NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde0.62
    2NAD metabolism
    NAD metabolism0.43
    Nicotinate and nicotinamide metabolism0.43
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4tryptophan utilization II
    tryptophan utilization II0.70
    tryptophan utilization I0.70
    5Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for QPRT
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for QPRT
        NAD metabolism

    4 BioSystems Pathways for QPRT
        NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde
    NAD biosynthesis II (from tryptophan)
    tryptophan utilization II
    tryptophan utilization I


    4        Reactome Pathways for QPRT
        Nicotinate metabolism
    Metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors


    2         Kegg Pathways  (Kegg details for QPRT):
        Nicotinate and nicotinamide metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: NADC_HUMAN, Q15274
    Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1


    QPRT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QPRT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for QPRT (Q152742, 3 ENSP000003787824) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUFUQ9UMX12, 3, ENSP000003589184MINT-66091 I2D: score=5 STRING: ENSP00000358918
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66042 I2D: score=5 STRING: ENSP00000377582
    IDH3GP515533, ENSP000002179014I2D: score=1 STRING: ENSP00000217901
    IDH3AP502133, ENSP000002995184I2D: score=1 STRING: ENSP00000299518
    KPNA6O606843I2D: score=5 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0009435NAD biosynthetic process IEA--
    GO:0019363pyridine nucleotide biosynthetic process ----
    GO:0019674NAD metabolic process TAS--

    QPRT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    QPRT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for QPRT (NADC)

    8 HMDB Compounds for QPRT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Nicotinic acid mononucleotide3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt (see all 23)321-02-8--
    Phosphoribosyl pyrophosphate5-Phospho-a-D-ribose-1-diphosphate (see all 37)7540-64-9--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    PyridineAzabenzene (see all 6)110-86-1--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Quinolinic acidpyridine-2,3-carboxylate (see all 10)89-00-9--

    1 DrugBank Compound for QPRT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Niacin3-Pyridinecarboxylic acid (see all 9)59-67-6targetbinder15837705 15753098 11758903

    3 Novoseek inferred chemical compound relationships for QPRT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    namn 96.7 4 9016724 (2), 11145065 (1)
    quinolinic acid 89.9 26 9016724 (3), 11145065 (2), 17868694 (2), 16472078 (2) (see all 11)
    niacin 52.4 3 15837705 (1), 9473669 (1)

    Search CenterWatch for drugs/clinical trials and news about QPRT / NADC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for QPRT gene: 
    NM_014298.3  

    Unigene Cluster for QPRT:

    Quinolinate phosphoribosyltransferase
    Hs.513484  [show with all ESTs]
    Unigene Representative Sequence: NM_014298
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219771 ENST00000395384(uc002dto.3 uc010vdu.2) ENST00000562473
    ENST00000564967
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat QPRT
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate QPRT:
    hsa-miR-588 hsa-miR-4252
    SwitchGear 3'UTR luciferase reporter plasmidQPRT 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for QPRT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QPRT
    Clone
    Products:
         
    OriGene clones in human, mouse for QPRT (see all 8)
    OriGene ORF clones in mouse, rat for QPRT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: QPRT (NM_014298)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for QPRT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QPRT
    Sirion Biotech Customized lentivirus for stable overexpression of QPRT 
                         Customized lentivirus expression plasmids for stable overexpression of QPRT 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for QPRT
    OriGene qSTAR qPCR primer pairs in human, mouse for QPRT
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat QPRT
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QPRT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QPRT

    Additional mRNA sequence: 

    AK293195.1 BC005060.1 BC010033.2 BC018910.2 BT007231.1 D78177.1 

    14 DOTS entries:

    DT.120696423  DT.414520  DT.120696998  DT.95137093  DT.100784782  DT.100659515  DT.100784778  DT.120696260 
    DT.95082378  DT.100009582  DT.120695401  DT.120696832  DT.455060  DT.92430926 

    24/264 AceView cDNA sequences (see all 264):

    BG576832 AW059610 BX283118 BM711970 BG820380 BG327095 AA421525 AW293885 
    BI822033 CR600977 CR601465 BI870607 CR603957 BX104943 AL531128 BC010033 
    AA421560 AW263079 AA343173 AA337770 BQ223326 AA309681 J04536 X60502 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for QPRT    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                      -     -     -                           
    SP4:        -                                                                     
    SP5:                                -     -     -     -                           


    ECgene alternative splicing isoforms for QPRT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    QPRT expression in normal human tissues (normalized intensities)      QPRT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTAACGTG
    QPRT Expression
    About this image


    QPRT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Liver (Hepatobiliary System)
     
     Adrenal Gland (Endocrine System)

    See QPRT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for QPRT

    SOURCE GeneReport for Unigene cluster: Hs.513484
        SABiosciences Custom PCR Arrays for QPRT
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for QPRT
    OriGene qSTAR qPCR primer pairs in human, mouse for QPRT
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat QPRT
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QPRT
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QPRT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QPRT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for QPRT gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Qprt1 , 5 quinolinate phosphoribosyltransferase1, 5 81.41(n)1
    84.01(a)1
      7 (69.33 cM)5
    673751  NM_133686.11  NP_598447.11 
     1271071145 
    lizard
    (Anolis carolinensis)
    Reptilia QPRT6
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343516.1(301415-304397)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.87142 Oncorhynchus mykiss transcribed sequence with weak more 76.4(n)    BX314563.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BNA61 Bna6p 51.44(n)
    47.57(a)
      850608   NP_602317.3 


    ENSEMBL Gene Tree for QPRT (if available)
    TreeFam Gene Tree for QPRT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/375 SNPs in QPRT are shown (see all 375)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0502194
    ----see VAR_0502192 T A mis40--------
    rs1866362861,2
    --27349726(+) AGGTGC/TGGCAG 1 -- us2k10--------
    rs1478443321,2
    C--27350026(+) GGCTGA/CGGCAG 1 -- us2k10--------
    rs1919337331,2
    --27350281(+) GAAGGG/TAAGGG 1 -- us2k10--------
    rs770592331,2
    C--27350348(+) TCTCAA/GTTGGA 1 -- us2k10--------
    rs1469808061,2
    --27350349(+) CTCAGC/TTGGAC 1 -- us2k10--------
    rs791396141,2
    C,F--27350378(+) GCCATT/CACATT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1836697061,2
    --27350558(+) GGGAGA/GGATGG 1 -- us2k10--------
    rs1145637361,2
    C,F--27350573(+) TCTGTA/GTGTCT 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs1877600411,2
    --27350668(+) GAGTCA/GCTGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for QPRT (29690329 - 29710020 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for QPRT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833183CNV Loss17160897
    dgv34n68CNV Loss17160897
    esv23737CNV Gain19812545
    dgv845e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing QPRT
    DNA2.0 Custom Variant and Variant Library Synthesis for QPRT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606248    OMIM disorders: --

    10 diseases for QPRT:    About MalaCards
    pellagra    seizure disorder    follicular thyroid carcinoma    huntington's disease
    alzheimer's disease    pneumonia    tuberculosis    multiple sclerosis
    thyroiditis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for QPRT:
    Pellagra

    QPRT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for QPRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for QPRT gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with QPRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. (PubMed id 9473669)1, 2, 3, 9 Fukuoka S.... Shibata K. (1998)
    2. Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. (PubMed id 17868694)1, 2, 9 Liu H....Naismith J.H. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study. (PubMed id 19321014)1, 9 Hinsch N....Hansmann M.L. (2009)
    5. Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mungbean (Phaseolus aureus) seeds. (PubMed id 15837705)7, 9 Zheng X.Q....Ashihara H. (2005)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23475 HGNC: 9755 AceView: SPNandQPRT Ensembl:ENSG00000103485 euGenes: HUgn23475
    ECgene: QPRT Kegg: 23475 H-InvDB: QPRT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for QPRT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for QPRT gene:
    Search GeneIP for patents involving QPRT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for QPRT   OriGene RNAi products in human, mouse, rat for QPRT  
     OriGene qPCR primer pairs and template standards for QPRT   OriGene Protein Over-expression Lysate for QPRT  
     OriGene MassSpec something-or-other for QPRT   OriGene clones in human, mouse for QPRT  
     OriGene qSTAR qPCR primer pairs in human, mouse for QPRT   OriGene Purified Protein for QPRT  
     OriGene ORF clones in mouse, rat for QPRT   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for QPRT   OriGene Custom Protein Services for QPRT  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat QPRT
     QIAGEN SeqTarget long-range PCR primers for resequencing QPRT
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QPRT
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QPRT
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QPRT
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QPRT
     GenScript Custom Purified and Recombinant Proteins Services for QPRT GenScript cDNA clones with any tag delivered in your preferred vector for QPRT
     GenScript Custom Assay Services for QPRT GenScript Custom Superior Antibodies Services for QPRT
     GenScript Custom overexpressing Cell Line Services for QPRT CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in QPRT promoter
     Search Chromatin IP Primers for QPRT
     RT2 qPCR Primer Assay in human, mouse, rat QPRT
     Search GNC Networks for QPRT
     SABiosciences Custom PCR Arrays for QPRT
     Search Tocris compounds for QPRT (NADC)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for QPRT
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     QPRT antibodies
     QPRT proteins
     QPRT lysates
     Antibodies for QPRT
     See all of Abcam's Antibodies, Kits and Proteins for QPRT
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for QPRT




     Proteins for QPRT
     Antibodies for QPRT
     ELISAs for QPRT
     CLIAs for QPRT
     Search LifeMap BioReagents cell lines for QPRT
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QPRT
     SwitchGear 3'UTR luciferase reporter plasmids for QPRT
     SwitchGear Promoter luciferase reporter plasmids for QPRT
     ThermoFisher Antibodies for QPRT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QPRT
     inGenious Targeting Laboratory - Custom generated mouse model solutions for QPRT
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for QPRT
    Customized:
     lentivirus for stable overexpression of QPRT
     lentivirus expression plasmids for stable overexpression of QPRT
     adenovirus for overexpression of QPRT
     LSBio Antibodies in human, mouse, rat for QPRT
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      QPRT gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4