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Aliases for QPRT Gene

Aliases for QPRT Gene

  • Quinolinate Phosphoribosyltransferase 2 3
  • Nicotinate-Nucleotide Pyrophosphorylase (Carboxylating) 2 3
  • EC 4 63
  • QAPRTase 3 4
  • QPRTase 3 4
  • Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating] 3
  • Quinolinate Phosphoribosyltransferase [Decarboxylating] 4
  • Epididymis Secretory Sperm Binding Protein Li 90n 3
  • HEL-S-90n 3

External Ids for QPRT Gene

Previous GeneCards Identifiers for QPRT Gene

  • GC16M028713
  • GC16P030014
  • GC16P029688
  • GC16P029728
  • GC16P029597
  • GC16P027351
  • GC16P029675
  • GC16P029690

Summaries for QPRT Gene

Entrez Gene Summary for QPRT Gene

  • This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for QPRT Gene

QPRT (Quinolinate Phosphoribosyltransferase) is a Protein Coding gene. Diseases associated with QPRT include pellagra and seizure disorder. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include protein homodimerization activity and nicotinate-nucleotide diphosphorylase (carboxylating) activity.

UniProtKB/Swiss-Prot for QPRT Gene

  • Involved in the catabolism of quinolinic acid (QA).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QPRT Gene

Genomics for QPRT Gene

Regulatory Elements for QPRT Gene

Genomic Location for QPRT Gene

29,679,008 bp from pter
29,698,699 bp from pter
19,692 bases
Plus strand

Genomic View for QPRT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for QPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPRT Gene

Proteins for QPRT Gene

  • Protein details for QPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nicotinate-nucleotide pyrophosphorylase [carboxylating]
    Protein Accession:
    Secondary Accessions:
    • Q53XW7
    • Q96G22
    • Q9BSG6

    Protein attributes for QPRT Gene

    297 amino acids
    Molecular mass:
    30846 Da
    Quaternary structure:
    • Hexamer formed by 3 homodimers.

    Three dimensional structures from OCA and Proteopedia for QPRT Gene

neXtProt entry for QPRT Gene

Proteomics data for QPRT Gene at MOPED

Selected DME Specific Peptides for QPRT Gene

Post-translational modifications for QPRT Gene

  • Ubiquitination at Lys183 and Lys288
  • Modification sites at PhosphoSitePlus

Other Protein References for QPRT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for QPRT Gene

Suggested Antigen Peptide Sequences for QPRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NadC/ModD family.
  • Belongs to the NadC/ModD family.
genes like me logo Genes that share domains with QPRT: view

No data available for Gene Families for QPRT Gene

Function for QPRT Gene

Molecular function for QPRT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for QA (at 0.1 mM PRPP) {ECO:0000269 PubMed:17868694}; KM=23 uM for QA (at 0.3 mM PRPP) {ECO:0000269 PubMed:17868694}; Vmax=1.2 uM/min/mg enzyme (at 0.3 mM QA and 0.1 mM PRPP) {ECO:0000269 PubMed:17868694}; Vmax=0.93 uM/min/mg enzyme (at 0.3 mM QA and 0.3 mM PRPP) {ECO:0000269 PubMed:17868694};
UniProtKB/Swiss-Prot CatalyticActivity:
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
UniProtKB/Swiss-Prot Function:
Involved in the catabolism of quinolinic acid (QA).

Enzyme Numbers (IUBMB) for QPRT Gene

Gene Ontology (GO) - Molecular Function for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity IDA 17868694
GO:0016763 transferase activity, transferring pentosyl groups --
GO:0042803 protein homodimerization activity IDA 17868694
genes like me logo Genes that share ontologies with QPRT: view

Phenotypes for QPRT Gene

GenomeRNAi human phenotypes for QPRT:
genes like me logo Genes that share phenotypes with QPRT: view

Animal Model Products

miRNA for QPRT Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for QPRT

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for QPRT Gene

Localization for QPRT Gene

Subcellular locations from

Jensen Localization Image for QPRT Gene COMPARTMENTS Subcellular localization image for QPRT gene
Compartment Confidence
cytosol 4
extracellular 2
plasma membrane 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with QPRT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for QPRT Gene

Pathways for QPRT Gene

SuperPathways for QPRT Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Nicotinate and nicotinamide metabolism
3 tryptophan utilization II
4 Metabolism
5 Disease
genes like me logo Genes that share pathways with QPRT: view

UniProtKB/Swiss-Prot Q15274-NADC_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1

Gene Ontology (GO) - Biological Process for QPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0009435 NAD biosynthetic process IEA --
GO:0019363 pyridine nucleotide biosynthetic process --
GO:0019674 NAD metabolic process TAS --
genes like me logo Genes that share ontologies with QPRT: view

Drugs for QPRT Gene

(1) Drugbank Compounds for QPRT Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 3-carboxypyridine
59-67-6 938 Target binder approved, investigational, nutraceutical

(10) HMDB Compounds for QPRT Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
  • 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt
nicotinate beta-D-ribonucleotide
Nicotinic acid
  • 3-Carboxylpyridine
Nicotinic acid mononucleotide
  • 3-Carboxy-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt

(3) Novoseek inferred chemical compound relationships for QPRT Gene

Compound -log(P) Hits PubMed IDs
namn 96.7 3
quinolinic acid 89.9 16
niacin 52.4 2
genes like me logo Genes that share compounds with QPRT: view

Transcripts for QPRT Gene

Unigene Clusters for QPRT Gene

Quinolinate phosphoribosyltransferase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for QPRT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for QPRT Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP3: - - -
SP4: -
SP5: - - - -

Relevant External Links for QPRT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for QPRT Gene

mRNA expression in normal human tissues for QPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for QPRT Gene

This gene is overexpressed in Liver (8.6), Adrenal Gland (5.8), and Kidney - Cortex (5.6).

Protein differential expression in normal tissues for QPRT Gene

This gene is overexpressed in Liver, secretome (22.1) and Kidney (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for QPRT Gene

SOURCE GeneReport for Unigene cluster for QPRT Gene Hs.513484

genes like me logo Genes that share expressions with QPRT: view

Expression partners for QPRT Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for QPRT Gene

Orthologs for QPRT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for QPRT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia QPRT 35
  • 86.51 (n)
  • 88.44 (a)
  • 87 (a)
(Canis familiaris)
Mammalia QPRT 35
  • 85.41 (n)
  • 86.2 (a)
  • 86 (a)
(Mus musculus)
Mammalia Qprt 35
  • 81.41 (n)
  • 84.01 (a)
Qprt 16
Qprt 36
  • 82 (a)
(Pan troglodytes)
Mammalia QPRT 35
  • 98.55 (n)
  • 99.13 (a)
(Rattus norvegicus)
Mammalia Qprt 35
  • 81.07 (n)
  • 82.65 (a)
(Monodelphis domestica)
Mammalia QPRT 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia QPRT 36
  • 69 (a)
(Anolis carolinensis)
Reptilia QPRT 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495332 35
  • 55.32 (n)
  • 54.39 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8714 35
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR271W 35
  • 52.43 (n)
  • 48.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA6 35
  • 51.44 (n)
  • 47.57 (a)
BNA6 36
  • 43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons QPT 35
  • 45.76 (n)
  • 37.71 (a)
(Oryza sativa)
Liliopsida Os09g0553600 35
  • 43.91 (n)
  • 36.57 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02998 35
  • 54.26 (n)
  • 48.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1371 36
  • 38 (a)
Species with no ortholog for QPRT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for QPRT Gene

Gene Tree for QPRT (if available)
Gene Tree for QPRT (if available)

Paralogs for QPRT Gene

No data available for Paralogs for QPRT Gene

Variants for QPRT Gene

Sequence variations from dbSNP and Humsavar for QPRT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1044184 -- 29,694,933(+) CTGCC(A/C)ACTGC missense, reference
rs1134700 -- 29,698,456(+) AACTA(C/T)TTGTG downstream-variant-500B
rs2303255 - 29,695,123(-) GCGAG(A/G)CGGCC reference, missense
rs2370364 -- 29,690,219(-) agcca(C/T)aaaaa intron-variant
rs2864137 -- 29,695,925(-) CAGGC(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QPRT Gene

Variant ID Type Subtype PubMed ID
dgv845e1 CNV Complex 17122850
nsv833183 CNV Loss 17160897
dgv34n68 CNV Loss 17160897
esv23737 CNV Gain 19812545

Relevant External Links for QPRT Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QPRT Gene

Disorders for QPRT Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for QPRT Gene in MalaCards »

(2) Diseases for QPRT Gene

(1) University of Copenhagen DISEASES for QPRT Gene

genes like me logo Genes that share disorders with QPRT: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for QPRT Gene

Publications for QPRT Gene

  1. Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. (PMID: 9473669) Fukuoka S. … Shibata K. (Biochim. Biophys. Acta 1998) 2 3 4 23
  2. Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. (PMID: 17868694) Liu H. … Naismith J.H. (J. Mol. Biol. 2007) 3 4 23
  3. Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mungbean (Phaseolus aureus) seeds. (PMID: 15837705) Zheng X.Q. … Ashihara H. (J. Exp. Bot. 2005) 23 25 26
  4. QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study. (PMID: 19321014) Hinsch N. … Hansmann M.L. (BMC Cancer 2009) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for QPRT Gene

Sources for QPRT Gene

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