Aliases for QPRT Gene
External Ids for QPRT Gene
Previous GeneCards Identifiers for QPRT Gene
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for QPRT Gene
QPRT (Quinolinate Phosphoribosyltransferase) is a Protein Coding gene. Diseases associated with QPRT include Seizure Disorder. Among its related pathways are Tryptophan metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring pentosyl groups. An important paralog of this gene is ENSG00000277669.
UniProtKB/Swiss-Prot for QPRT Gene
Involved in the catabolism of quinolinic acid (QA).