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Aliases for QPCTL Gene

Aliases for QPCTL Gene

  • Glutaminyl-Peptide Cyclotransferase-Like 2 3 5
  • Golgi-Resident Glutaminyl-Peptide Cyclotransferase 3 4
  • Glutaminyl Cyclase-Like 2 3
  • EC 2.3.2.5 4 63
  • IsoQC 3 4
  • GQC 3 4
  • EC 2.3.2 63

External Ids for QPCTL Gene

Previous GeneCards Identifiers for QPCTL Gene

  • GC19P050888
  • GC19P046195
  • GC19P042624

Summaries for QPCTL Gene

GeneCards Summary for QPCTL Gene

QPCTL (Glutaminyl-Peptide Cyclotransferase-Like) is a Protein Coding gene. GO annotations related to this gene include glutaminyl-peptide cyclotransferase activity. An important paralog of this gene is QPCT.

UniProtKB/Swiss-Prot for QPCTL Gene

  • Responsible for the biosynthesis of pyroglutamyl peptides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QPCTL Gene

Genomics for QPCTL Gene

Regulatory Elements for QPCTL Gene

Enhancers for QPCTL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around QPCTL on UCSC Golden Path with GeneCards custom track

Promoters for QPCTL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around QPCTL on UCSC Golden Path with GeneCards custom track

Genomic Location for QPCTL Gene

Chromosome:
19
Start:
45,692,381 bp from pter
End:
45,703,990 bp from pter
Size:
11,610 bases
Orientation:
Plus strand

Genomic View for QPCTL Gene

Genes around QPCTL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QPCTL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QPCTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPCTL Gene

Proteins for QPCTL Gene

  • Protein details for QPCTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXS2-QPCTL_HUMAN
    Recommended name:
    Glutaminyl-peptide cyclotransferase-like protein
    Protein Accession:
    Q9NXS2
    Secondary Accessions:
    • Q53HE4
    • Q96F74

    Protein attributes for QPCTL Gene

    Size:
    382 amino acids
    Molecular mass:
    42924 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for QPCTL Gene

    Alternative splice isoforms for QPCTL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QPCTL Gene

Proteomics data for QPCTL Gene at MOPED

Selected DME Specific Peptides for QPCTL Gene

Post-translational modifications for QPCTL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for QPCTL Gene

Domains & Families for QPCTL Gene

Protein Domains for QPCTL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for QPCTL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXS2

UniProtKB/Swiss-Prot:

QPCTL_HUMAN :
  • Belongs to the glutaminyl-peptide cyclotransferase family.
Family:
  • Belongs to the glutaminyl-peptide cyclotransferase family.
genes like me logo Genes that share domains with QPCTL: view

No data available for Gene Families for QPCTL Gene

Function for QPCTL Gene

Molecular function for QPCTL Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
UniProtKB/Swiss-Prot Function:
Responsible for the biosynthesis of pyroglutamyl peptides.

Enzyme Numbers (IUBMB) for QPCTL Gene

Phenotypes for QPCTL Gene

genes like me logo Genes that share phenotypes with QPCTL: view

Animal Model Products

miRNA for QPCTL Gene

miRTarBase miRNAs that target QPCTL

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for QPCTL Gene

Localization for QPCTL Gene

Subcellular locations from UniProtKB/Swiss-Prot for QPCTL Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QPCTL Gene COMPARTMENTS Subcellular localization image for QPCTL gene
Compartment Confidence
golgi apparatus 5
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for QPCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with QPCTL: view

Pathways & Interactions for QPCTL Gene

SuperPathways for QPCTL Gene

No Data Available

Gene Ontology (GO) - Biological Process for QPCTL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for QPCTL Gene

Drugs & Compounds for QPCTL Gene

(1) Additional Compounds for QPCTL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
genes like me logo Genes that share compounds with QPCTL: view

Transcripts for QPCTL Gene

Unigene Clusters for QPCTL Gene

Glutaminyl-peptide cyclotransferase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QPCTL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for QPCTL Gene

GeneLoc Exon Structure for
QPCTL
ECgene alternative splicing isoforms for
QPCTL

Expression for QPCTL Gene

mRNA expression in normal human tissues for QPCTL Gene

Protein differential expression in normal tissues from HIPED for QPCTL Gene

This gene is overexpressed in Nasal epithelium (57.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for QPCTL Gene



SOURCE GeneReport for Unigene cluster for QPCTL Gene Hs.631556

genes like me logo Genes that share expression patterns with QPCTL: view

Protein tissue co-expression partners for QPCTL Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for QPCTL Gene

Orthologs for QPCTL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for QPCTL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia QPCTL 35
  • 85.34 (n)
  • 84.03 (a)
QPCTL 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QPCTL 35
  • 86.3 (n)
  • 87.43 (a)
QPCTL 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qpctl 35
  • 81.85 (n)
  • 82.72 (a)
Qpctl 16
Qpctl 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Qpctl 35
  • 81.33 (n)
  • 82.72 (a)
oppossum
(Monodelphis domestica)
Mammalia QPCTL 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QPCTL 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia QPCTL 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves QPCTL 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QPCTL 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qpctl 35
  • 54.61 (n)
  • 56.23 (a)
zebrafish
(Danio rerio)
Actinopterygii qpctla 36
  • 48 (a)
OneToMany
qpctlb 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32413 36
  • 30 (a)
ManyToMany
QC 36
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea H27A22.1 36
  • 37 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER189W 35
  • 50.06 (n)
  • 40.3 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04576g 35
  • 44.92 (n)
  • 39.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YFR018C 35
  • 45.12 (n)
  • 37.14 (a)
-- 36
  • 29 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09018 35
  • 53.07 (n)
  • 45.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for QPCTL:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QPCTL Gene

ENSEMBL:
Gene Tree for QPCTL (if available)
TreeFam:
Gene Tree for QPCTL (if available)

Paralogs for QPCTL Gene

Paralogs for QPCTL Gene

(1) SIMAP similar genes for QPCTL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with QPCTL: view

Variants for QPCTL Gene

Sequence variations from dbSNP and Humsavar for QPCTL Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs28708996 - 45,698,554(+) AGCCC(A/C/T)GGTGA reference, synonymous-codon, missense
rs7256197 -- 45,699,564(+) gaggc(A/G)ggtgg intron-variant
rs7256920 -- 45,699,825(+) tattc(A/G)ggagg intron-variant
rs1008773 -- 45,698,397(+) actga(C/T)tcgga intron-variant
rs71175210 -- 45,699,932(+) AAAAA(-/A)TTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QPCTL Gene

Variant ID Type Subtype PubMed ID
nsv912159 CNV Loss 21882294
dgv3954n71 CNV Loss 21882294
dgv3955n71 CNV Loss 21882294

Variation tolerance for QPCTL Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for QPCTL Gene

Disorders for QPCTL Gene

Relevant External Links for QPCTL

Genetic Association Database (GAD)
QPCTL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QPCTL

No disorders were found for QPCTL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for QPCTL Gene

Publications for QPCTL Gene

  1. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. (PMID: 21288892) Huang K.F. … Wang A.H. (J. Biol. Chem. 2011) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. (PMID: 24861553) Wen W. … Tanaka T. (Hum. Mol. Genet. 2014) 3

Products for QPCTL Gene

Sources for QPCTL Gene

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