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Aliases for QPCTL Gene

Aliases for QPCTL Gene

  • Glutaminyl-Peptide Cyclotransferase-Like 2 3
  • Golgi-Resident Glutaminyl-Peptide Cyclotransferase 3 4
  • Glutaminyl Cyclase-Like 2 3
  • EC 2.3.2.5 4 64
  • IsoQC 3 4
  • GQC 3 4
  • Glutaminyl-Peptide Cyclotransferase-Like Protein 3
  • EC 2.3.2 64

External Ids for QPCTL Gene

Summaries for QPCTL Gene

GeneCards Summary for QPCTL Gene

QPCTL (Glutaminyl-Peptide Cyclotransferase-Like) is a Protein Coding gene. GO annotations related to this gene include peptidase activity and glutaminyl-peptide cyclotransferase activity. An important paralog of this gene is QPCT.

UniProtKB/Swiss-Prot for QPCTL Gene

  • Responsible for the biosynthesis of pyroglutamyl peptides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QPCTL Gene

Genomics for QPCTL Gene

Genomic Location for QPCTL Gene

Start:
45,692,483 bp from pter
End:
45,703,990 bp from pter
Size:
11,508 bases
Orientation:
Plus strand

Genomic View for QPCTL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for QPCTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPCTL Gene

Regulatory Elements for QPCTL Gene

Proteins for QPCTL Gene

  • Protein details for QPCTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXS2-QPCTL_HUMAN
    Recommended name:
    Glutaminyl-peptide cyclotransferase-like protein
    Protein Accession:
    Q9NXS2
    Secondary Accessions:
    • Q53HE4
    • Q96F74

    Protein attributes for QPCTL Gene

    Size:
    382 amino acids
    Molecular mass:
    42924 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for QPCTL Gene

    Alternative splice isoforms for QPCTL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QPCTL Gene

Proteomics data for QPCTL Gene at MOPED

Selected DME Specific Peptides for QPCTL Gene

Post-translational modifications for QPCTL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for QPCTL Gene

Domains for QPCTL Gene

Protein Domains for QPCTL Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

QPCTL_HUMAN
Family:
  • Belongs to the glutaminyl-peptide cyclotransferase family.:
    • Q9NXS2
genes like me logo Genes that share domains with QPCTL: view

No data available for Gene Families for QPCTL Gene

Function for QPCTL Gene

Molecular function for QPCTL Gene

UniProtKB/Swiss-Prot CatalyticActivity: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
UniProtKB/Swiss-Prot Function: Responsible for the biosynthesis of pyroglutamyl peptides.

Enzyme Numbers (IUBMB) for QPCTL Gene

Gene Ontology (GO) - Molecular Function for QPCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IDA 21288892
GO:0016603 glutaminyl-peptide cyclotransferase activity IDA 18486145
genes like me logo Genes that share ontologies with QPCTL: view

Phenotypes for QPCTL Gene

genes like me logo Genes that share phenotypes with QPCTL: view

miRNA for QPCTL Gene

miRTarBase miRNAs that target QPCTL

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for QPCTL Gene

Localization for QPCTL Gene

Subcellular locations from UniProtKB/Swiss-Prot for QPCTL Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QPCTL Gene COMPARTMENTS Subcellular localization image for QPCTL gene
Compartment Confidence
golgi apparatus 5
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for QPCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with QPCTL: view

Pathways for QPCTL Gene

SuperPathways for QPCTL Gene

No Data Available

Gene Ontology (GO) - Biological Process for QPCTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA 18486145
genes like me logo Genes that share ontologies with QPCTL: view

No data available for Pathways by source for QPCTL Gene

Transcripts for QPCTL Gene

Unigene Clusters for QPCTL Gene

Glutaminyl-peptide cyclotransferase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QPCTL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for QPCTL Gene

GeneLoc Exon Structure for
QPCTL
ECgene alternative splicing isoforms for
QPCTL

Expression for QPCTL Gene

mRNA expression in normal human tissues for QPCTL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for QPCTL Gene

SOURCE GeneReport for Unigene cluster for QPCTL Gene Hs.631556

genes like me logo Genes that share expressions with QPCTL: view

Orthologs for QPCTL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for QPCTL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QPCTL 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia QPCTL 36
  • 85.34 (n)
  • 84.03 (a)
QPCTL 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QPCTL 36
  • 86.3 (n)
  • 87.43 (a)
QPCTL 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qpctl 36
  • 81.85 (n)
  • 82.72 (a)
Qpctl 16
Qpctl 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia QPCTL 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QPCTL 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Qpctl 36
  • 81.33 (n)
  • 82.72 (a)
chicken
(Gallus gallus)
Aves QPCTL 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QPCTL 37
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qpctl 36
  • 54.61 (n)
  • 56.23 (a)
zebrafish
(Danio rerio)
Actinopterygii qpctla 37
  • 48 (a)
OneToMany
qpctlb 37
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32413 37
  • 30 (a)
ManyToMany
QC 37
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea H27A22.1 37
  • 37 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER189W 36
  • 50.06 (n)
  • 40.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 29 (a)
OneToMany
YFR018C 36
  • 45.12 (n)
  • 37.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04576g 36
  • 44.92 (n)
  • 39.38 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09018 36
  • 53.07 (n)
  • 45.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
Species with no ortholog for QPCTL:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QPCTL Gene

ENSEMBL:
Gene Tree for QPCTL (if available)
TreeFam:
Gene Tree for QPCTL (if available)

Paralogs for QPCTL Gene

Paralogs for QPCTL Gene

Selected SIMAP similar genes for QPCTL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with QPCTL: view

Variants for QPCTL Gene

Sequence variations from dbSNP and Humsavar for QPCTL Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1008773 -- 45,698,397(+) actga(C/T)tcgga intron-variant
rs2287019 -- 45,698,914(+) GAATG(C/T)GGAGG intron-variant
rs3073176 -- 45,703,952(+) AAATA(-/AATA)TTTTT utr-variant-3-prime
rs4803847 -- 45,701,680(+) ATTCA(C/T)TCTTG intron-variant
rs4803848 -- 45,701,792(+) CCCAC(C/T)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QPCTL Gene

Variant ID Type Subtype PubMed ID
nsv912159 CNV Loss 21882294
dgv3954n71 CNV Loss 21882294
dgv3955n71 CNV Loss 21882294

Relevant External Links for QPCTL Gene

HapMap Linkage Disequilibrium report
QPCTL

Disorders for QPCTL Gene

Relevant External Links for QPCTL

Genetic Association Database (GAD)
QPCTL
genes like me logo Genes that share disorders with QPCTL: view

No data available for UniProtKB/Swiss-Prot for QPCTL Gene

Publications for QPCTL Gene

  1. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. (PMID: 18486145) Cynis H. … Schilling S. (J. Mol. Biol. 2008) 3 4
  2. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. (PMID: 21288892) Huang K.F. … Wang A.H. (J. Biol. Chem. 2011) 3 4
  3. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes E.K. … Loos R.J. (Nat. Genet. 2010) 3 49
  4. Proteomic profiling of Myc-associated proteins. (PMID: 21150319) Agrawal P. … Sedivy J.M. (Cell Cycle 2010) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for QPCTL Gene

Sources for QPCTL Gene

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