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QPCTL Gene

protein-coding GIFtS: 43

GC19P050888

glutaminyl-peptide cyclotransferase-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.3.2.- ^³
FLJ20084 ^¹, ²

Descriptions
glutaminyl cyclase-like ^²
glutaminyl-peptide cyclotransferase-like ^²

External Ids
HGNC: 25952¹
Entrez Gene: 54814²
UniProtKB: Q9NXS2³
Ensembl: ENSG00000011478⁷

Search outside databases for aliases for QPCTL gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the QPCTL gene

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32

QPCTL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P050888: (about GC identifiers)

Start:	50,887,772 bp from pter
End:	50,899,050 bp from pter
Size:	11,279 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: QPCTL_HUMAN, Q9NXS2 (See protein sequence)

Recommended Name: Glutaminyl-peptide cyclotransferase-like protein

Size: 382 amino acids; 42864 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Secondary accessions: Q53HE4 Q96F74

Alternative splicing: 2 isoforms: Q9NXS2-1 Q9NXS2-2

REFSEQ proteins: NP_060129.2

ENSEMBL proteins:

ENSP00000300869 ENSP00000012049

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (QPCTL)
	Human Recombinant Proteins from Abnova (QPCTL)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for QPCTL:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (QPCTL), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (QPCTL)
	Novus Biologicals Antibodies for QPCTL

Assays for QPCTL:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NXS2

ProtoNet protein and cluster: Q9NXS2

UniProtKB/Swiss-Prot: QPCTL_HUMAN, Q9NXS2

Similarity: Belongs to the glutaminyl-peptide cyclotransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QPCTL)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017659

Applied Biosystems Silencer® siRNAs for QPCTL

Sigma-Aldrich siRNA and siRNA Panels for QPCTL

Sigma-Aldrich shRNA for QPCTL

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for QPCTL
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_017659
Myc/DDK tagged cDNA clone in CMV expression vector: NM_017659
untagged cDNA clones in CMV expression vector (see all 2): NM_017659

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017659

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0008415	acyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for QPCTL (Q9NXS2¹) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
POLR1E Q9GZS1¹ EBI-1052839, EBI-359458
About this table
1 Gene Ontology (GO) biological process term (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for QPCTL

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QPCTL)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017659

Sigma-Aldrich siRNA and siRNA Panels for QPCTL

Sigma-Aldrich shRNA for QPCTL

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_017659

REFSEQ mRNAs for QPCTL gene:

NM_017659.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_017659

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017659
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_017659
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_017659

Additional cDNA sequence:

AK000091.1 AK172764.1 AK222636.1 BC011553.1 CR602598.1 S94540.1

6 DOTS entries:

DT.97837580 DT.75138379 DT.121498692 DT.99994231 DT.95150867 DT.100776871

24/36 AceView cDNA sequences (see all 36 ):

CR602598 BG763451 BM764176 BM798617 BM836386 BE253045 BX283143 BF980950

BM847134 BC011553 BX401107 BX328106 NM_017659 CD384958 BM798810 AK172764

AK000091 BG114847 BE539738 BG943452 AL599065 BP366175 AA357240 AA302811

highest scoring ESTs for QPCTL:

BE539738 BF919175 BG114847 BG763451 BI011857 AK000091 AK172764 BC011553 AI668990 AI814021

Unigene Cluster for QPCTL:

Glutaminyl-peptide cyclotransferase-like

Hs.719563 [show with all ESTs]

Unigene Representative Sequence: AK000091

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for QPCTL

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b
SP1:
SP2:							-

About this scheme

ECgene alternative splicing isoforms for QPCTL

2 Ensembl transcripts including schematic representations:

ENST00000300869 ENST00000012049

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

QPCTL expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for QPCTL

¹ / ² / ³

2 probe-sets matching QPCTL gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
220438_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_017659	0.60	1.00	0.82	1
220438_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719563

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for QPCTL gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	QPCTL¹	--	glutaminyl-peptide cyclotransferase-like	87.43(n) 88.74(a)	484437 XM_541552.1 XP_541552.1
chimpanzee (Pan troglodytes)	QPCTL¹	--	glutaminyl-peptide cyclotransferase-like	89.94(n) 86.44(a)	456135 XM_512756.2 XP_512756.2
cow (Bos taurus)	QPCTL¹	--	glutaminyl-peptide cyclotransferase-like	85.78(n) 84.82(a)	530871 NM_001075940.2 NP_001069408.1
rat (Rattus norvegicus)	Qpctl¹	--	glutaminyl-peptide cyclotransferase-like	82.81(n) 84.55(a)	292687 XM_214869.4 XP_214869.3
mouse (Mus musculus)	Qpctl^{1, 5}	7⁵	glutaminyl-peptide cyclotransferase-like^{1, 5}	83.33(n)¹ 84.29(a)¹	67369¹ NM_026111.3¹ NP_080387.2¹ AI430736⁵ AK007555⁵ (see all 14)

About this table Species with no ortholog for QPCTL

ENSEMBL Gene Tree for QPCTL

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for QPCTL gene

QPCT²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/60 NCBI SNPs in QPCTL are shown (see all 60 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 24)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11672416^1,2	C,F,H	50898265(+)	`TTGTCT/CCCTAA`	1	--	ut3¹ ese³		8		EU EA WA NA	780
	rs28708996^1,2	C	50893652(+)	`AGCCCC/TGGTGA`	1	P/L	mis¹ ese³		1		NA	78
	rs2287019^1,2	C,F,H	50894012(+)	`GAATGC/TGGAGG`	1	--	int¹		5		EA EU WA	1918
	rs11083779^1,2	A,F,H	50896718(+)	`GACTCT/CGAGGG`	1	--	int¹		3		EU EA	300
	rs1008773^1,2	A,C,H	50893495(+)	`actgaC/Ttcgga`	1	--	int¹		4		EU EA WA	418
	rs4803848^1,2	C,F,H	50896890(+)	`CCCACC/TTCCAG`	1	--	int¹		4		EU EA WA	420
--	rs6509232^1,2	A,C	50897329(+)	`tggcgA/Gggggg`	1	--	int¹		0	--	--	--	--
--	rs10413338^1,2	A,C	50892142(+)	`gaaacC/Tgagag`	1	--	int¹		0	--	--	--	--
--	rs7254257^1,2	A,C	50897726(+)	`gtgtcA/Gtggtg`	1	--	int¹		0	--	--	--	--
--	rs4803847^1,2	C	50896778(+)	`ATTCAC/TTCTTG`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for QPCTL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for QPCTL gene:

Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. (PubMed id 15782160)³ Kim J....Iyer V.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)⁴ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)³ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54814	HGNC: 25952	AceView: QPCTL	Ensembl:ENSG00000011478	euGenes: HUgn54814
ECgene: QPCTL	H-InvDB: QPCTL

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for QPCTL
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for QPCTL:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for QPCTL-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for QPCTL		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for QPCTL		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (QPCTL)
	Antibodies (QPCTL)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for QPCTL

Search Tocris compounds for QPCTL

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for QPCTL

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QPCTL Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for QPCTL

Summaries
for QPCTL

Genomic Location
for QPCTL

Proteins
for QPCTL

Protein Domains/
Families
for QPCTL

Gene Function
for QPCTL

Pathways & Interactions
for QPCTL

Drugs & Compounds
for QPCTL

Transcripts
for QPCTL

Expression
for QPCTL

Orthologs
for QPCTL

Paralogs
for QPCTL

SNPs/Variants
for QPCTL

Disorders & Mutations
for QPCTL

Medical News
for QPCTL

Publications
for QPCTL

Search for QPCTL

Genome Databases showing QPCTL

Other Databases showing QPCTL

Specialized Databases showing QPCTL

Licensable Technologies
for QPCTL

Services
for QPCTL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

QPCTL Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor QPCTL

Summariesfor QPCTL

Genomic Locationfor QPCTL

Proteinsfor QPCTL

Protein Domains/Familiesfor QPCTL

Gene Functionfor QPCTL

Pathways & Interactionsfor QPCTL

Drugs & Compoundsfor QPCTL

Transcriptsfor QPCTL

Expression for QPCTL

Orthologsfor QPCTL

Paralogsfor QPCTL

SNPs/Variantsfor QPCTL

Disorders & Mutationsfor QPCTL

Medical Newsfor QPCTL

Publicationsfor QPCTL

Search for QPCTL

Genome Databases showing QPCTL

Other Databases showing QPCTL

Specialized Databases showing QPCTL

Licensable Technologiesfor QPCTL

Servicesfor QPCTL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for QPCTL

Summaries
for QPCTL

Genomic Location
for QPCTL

Proteins
for QPCTL

Protein Domains/
Families
for QPCTL

Gene Function
for QPCTL

Pathways & Interactions
for QPCTL

Drugs & Compounds
for QPCTL

Transcripts
for QPCTL

Expression
for QPCTL

Orthologs
for QPCTL

Paralogs
for QPCTL

SNPs/Variants
for QPCTL

Disorders & Mutations
for QPCTL

Medical News
for QPCTL

Publications
for QPCTL

Licensable Technologies
for QPCTL

Services
for QPCTL