QPCTL Gene
protein-coding GIFtS: 44
GCID: GC19P046195
|
|
glutaminyl-peptide cyclotransferase-like
| |
Aliases
for QPCTL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutaminyl-Peptide Cyclotransferase-Like1 2 | | FLJ200841 | | Golgi-Resident Glutaminyl-Peptide Cyclotransferase2 3 | | Glutaminyl Cyclase-Like2 | | GQC1 | | Glutaminyl-Peptide Cyclotransferase-Like Protein2 | | IsoQC1 | | EC 2.3.28 | | EC 2.3.2.53 8 | | |
Export aliases for QPCTL gene to outside databasesPrevious GC identifers: GC19P050888 GC19P042624 |
Summaries
for QPCTL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: QPCTL_HUMAN, Q9NXS2Function: Responsible for the biosynthesis of pyroglutamyl peptides
|
Genomic Views
for QPCTL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the QPCTL gene promoter:
Max1 AREB6 PPAR-gamma1 AML1a PPAR-gamma2 AP-2gamma GATA-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for QPCTL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QPCTL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32QPCTL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P046195: view genomic region
(about GC identifiers)
Start:
|
46,195,741 bp from pter |
End:
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46,207,248 bp from pter |
Size:
|
11,508 bases |
Orientation:
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plus strand |
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Proteins
for QPCTL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: QPCTL_HUMAN, Q9NXS2 (See
protein sequence)Recommended Name: Glutaminyl-peptide cyclotransferase-like protein Size: 382 amino acids; 42924 Da
Cofactor: Binds 1 zinc ion per subunit
Subcellular location: Golgi apparatus membrane; Single-pass type I membrane protein
5 PDB 3D structures from  and Proteopedia  for QPCTL:3PB4 (3D)
3PB6 (3D)
3PB7 (3D)
3PB8 (3D)
3PB9 (3D)
Secondary accessions: Q53HE4 Q96F74Explore the universe of human proteins at neXtProt for QPCTL: NX_Q9NXS2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXS2
4/9 DME Specific Peptides for QPCTL (Q9NXS2) (see all 9)
QPCTL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001156849.1 NP_060129.2
ENSEMBL proteins: ENSP00000012049 ENSP00000387944 ENSP00000467813
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
QPCTL for ontologies About GeneDecksing
QPCTL Antibody Products:
Assay Products for QPCTL: |
Protein
Domains /
Families
for QPCTL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
QPCTL for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NXS2ProtoNet protein and cluster: Q9NXS2 UniProtKB/Swiss-Prot: QPCTL_HUMAN, Q9NXS2Similarity: Belongs to the glutaminyl-peptide cyclotransferase family |
Function
for QPCTL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: QPCTL_HUMAN, Q9NXS2Function: Responsible for the biosynthesis of pyroglutamyl peptidesCatalytic activity: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3)Enzyme Numbers (IUBMB): EC 2.3.2.51 2 EC 2.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QPCTL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QPCTL (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): QPCTL (NM_017659) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for QPCTL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QPCTL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QPCTL |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
QPCTL for ontologies About GeneDecksing
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Qpctl):
QPCTL for phenotypes About GeneDecksing
|
Pathways & Interactions
for QPCTL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QPCTL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/9 Interacting proteins for QPCTL (Q9NXS21, 2, 3 ENSP000000120494) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase |
IDA | 18486145 |
QPCTL for ontologies About GeneDecksing
|
Drugs & Compounds
for QPCTL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for QPCTL
Search CenterWatch for drugs/clinical trials and news about QPCTL
|
Transcripts
for QPCTL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for QPCTL gene (2 alternative transcripts): NM_001163377.1 NM_017659.3 Unigene Cluster for QPCTL: Glutaminyl-peptide cyclotransferase-like Hs.631556 [show with all ESTs]Unigene Representative Sequence: NM_0176594 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000012049(uc010xxr.2) ENST00000366382(uc010ekn.3) ENST00000591606
ENST00000592769
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QPCTL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QPCTL (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): QPCTL (NM_017659) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for QPCTL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QPCTL |
Additional cDNA sequence: AK000091.1 AK172764.1 AK222636.1 BC011553.1 S94540.1 6 DOTS entries: DT.97837580 DT.75138379 DT.100776871 DT.121498692 DT.99994231 DT.95150867 24/36 AceView cDNA sequences (see all 36): BM836386 BM764176 BX283143 BM798617 CR602598 BG763451 BE253045 BM847134 BX401107 AK000091 BF980950 BX328106 NM_017659 AK172764 BM798810 CD384958 BC011553 BE539738 BG114847 BP366175 BG943452 AL599065 AA302811 AA357240
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for QPCTL About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for QPCTL
|
Expression
for QPCTL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| QPCTL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTCTATAC
About this image
See QPCTL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for QPCTL
SOURCE GeneReport for Unigene cluster: Hs.631556
SABiosciences Custom PCR Arrays for QPCTL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for QPCTL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat QPCTL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QPCTL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QPCTL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QPCTL |
Orthologs
for QPCTL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for QPCTL gene from 7/25 species (see all 25) About this table
ENSEMBL Gene Tree for QPCTL (if available)
TreeFam Gene Tree for QPCTL (if available) |
Paralogs
for QPCTL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for QPCTL gene
- QPCT2
1 SIMAP similar gene for QPCTL using alignment to 2 protein entries: QPCTL_HUMAN (see all proteins):QPCT
QPCTL for paralogs About GeneDecksing
|
Genomic Variants
for QPCTL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for QPCTL (46195741 - 46207248 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for QPCTL: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QPCTL |
|
Disorders
/ Diseases
for QPCTL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for QPCTL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for QPCTL gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with QPCTL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. (PubMed id 18486145)1, 2 Cynis H....Schilling S. (2008)
- Meta-analysis identifies common variants associated wi th body mass index in east Asians. (PubMed id 22344219)1 Wen W....Shu X.O. (2012)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Association studies of novel obesity-related gene vari ants with quantitative metabolic phenotypes in a population-based sample of 6,03 9 Danish individuals. (PubMed id 21953277)1 Burgdorf K.S....Pedersen O. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. (PubMed id 21288892)2 Huang K.F....Wang A.H. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (2010)
- Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1 Weinmann L.... Meister G. (2009)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
|
External Searches for QPCTL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing QPCTL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing QPCTL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QPCTL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for QPCTL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for QPCTL gene:
Search GeneIP for patents involving QPCTL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for QPCTL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for QPCTL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for QPCTL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for QPCTL | | | OriGene Protein Over-expression Lysate for QPCTL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for QPCTL | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QPCTL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QPCTL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for QPCTL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for QPCTL | | OriGene Custom Protein Services for QPCTL | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat QPCTL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QPCTL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QPCTL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QPCTL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QPCTL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QPCTL |
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 |  |  |  | |
| | | | Search Tocris compounds for QPCTL |
| |  |  |  |  | | | | |
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 |
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 | | | QPCTL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QPCTL |
|  |  |  | | | | Search ThermoFisher Antibodies for QPCTL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QPCTL |
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