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Aliases for QPCT Gene

Aliases for QPCT Gene

  • Glutaminyl-Peptide Cyclotransferase 2 3 5
  • Glutaminyl Cyclase 2 3 4
  • Glutaminyl-TRNA Cyclotransferase 3 4
  • Glutamyl Cyclase 3 4
  • EC 2.3.2.5 4 61
  • SQC 3 4
  • EC 3 4
  • QC 3 4
  • GCT 3

External Ids for QPCT Gene

Previous GeneCards Identifiers for QPCT Gene

  • GC02P037536
  • GC02P037718
  • GC02P037546
  • GC02P037483
  • GC02P037425
  • GC02P037571
  • GC02P037313

Summaries for QPCT Gene

Entrez Gene Summary for QPCT Gene

  • This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]

GeneCards Summary for QPCT Gene

QPCT (Glutaminyl-Peptide Cyclotransferase) is a Protein Coding gene. Diseases associated with QPCT include Pulmonary Neuroendocrine Tumor. Among its related pathways are Innate Immune System. GO annotations related to this gene include glutaminyl-peptide cyclotransferase activity. An important paralog of this gene is QPCTL.

UniProtKB/Swiss-Prot for QPCT Gene

  • Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Gene Wiki entry for QPCT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QPCT Gene

Genomics for QPCT Gene

Regulatory Elements for QPCT Gene

Enhancers for QPCT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G037388 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +45.8 45787 3.0 PKNOX1 FOXA2 ATF1 WRNIP1 SIN3A YY1 TCF12 GATA2 ELK1 CBX5 LOC101929542 PRKD3 QPCT RNU6-939P CYP1B1 RMDN2 CDC42EP3 EIF2AK2 GC02P037427
GH02G037317 1.3 Ensembl ENCODE dbSUPER 11.4 -26.1 -26131 1.5 PKNOX1 MAX FEZF1 RAD21 CBX5 ZNF366 FOS ZNF600 MAFK L3MBTL2 CEBPZOS QPCT GC02M037305 PRKD3
GH02G037633 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.1 +301.7 301678 26.1 HDGF PKNOX1 WRNIP1 SIN3A ETS1 ZNF766 GATA2 ELK1 ZNF143 FOS CDC42EP3 LOC105374464 RNU6-939P QPCT EIF2AK2 CEBPZ CYP1B1 GC02P037671 GC02M037562
GH02G037664 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6 +324.2 324159 9.2 HDGF ATF1 PKNOX1 AGO1 WRNIP1 SIN3A ARID4B FEZF1 GLIS2 ZNF143 CDC42EP3 LOC105374464 QPCT CYP1B1 GC02P037671 GC02M037562
GH02G037760 0.6 FANTOM5 Ensembl 17.3 +417.0 417027 2.8 QPCT CDC42EP3 ENSG00000236572 GC02M037793
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around QPCT on UCSC Golden Path with GeneCards custom track

Promoters for QPCT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000115334 326 1001 HDGF ZFP64 KLF17 FEZF1 BMI1 ZBTB40 ZNF2 GLIS2 GATA2 ZNF366

Genomic Location for QPCT Gene

Chromosome:
2
Start:
37,344,574 bp from pter
End:
37,373,322 bp from pter
Size:
28,749 bases
Orientation:
Plus strand

Genomic View for QPCT Gene

Genes around QPCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
QPCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for QPCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPCT Gene

Proteins for QPCT Gene

  • Protein details for QPCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16769-QPCT_HUMAN
    Recommended name:
    Glutaminyl-peptide cyclotransferase
    Protein Accession:
    Q16769
    Secondary Accessions:
    • Q16770
    • Q3KRG6
    • Q53TR4

    Protein attributes for QPCT Gene

    Size:
    361 amino acids
    Molecular mass:
    40877 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for QPCT Gene

    Alternative splice isoforms for QPCT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QPCT Gene

Selected DME Specific Peptides for QPCT Gene

Q16769:
  • DSLYGSRHLA
  • GVPVLHLI
  • DDHIPFL
  • IFFDGEEAF
  • GATDSAVPC
  • LACHYDSK
  • GAPNPTF

Post-translational modifications for QPCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for QPCT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for QPCT (Glutaminyl-peptide Cyclotransferase/QPCT)
  • Abcam antibodies for QPCT
  • Santa Cruz Biotechnology (SCBT) Antibodies for QPCT

Protein Products

  • Abcam proteins for QPCT

Domains & Families for QPCT Gene

Protein Domains for QPCT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for QPCT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16769

UniProtKB/Swiss-Prot:

QPCT_HUMAN :
  • Belongs to the glutaminyl-peptide cyclotransferase family.
Family:
  • Belongs to the glutaminyl-peptide cyclotransferase family.
genes like me logo Genes that share domains with QPCT: view

No data available for Gene Families for QPCT Gene

Function for QPCT Gene

Molecular function for QPCT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
UniProtKB/Swiss-Prot Function:
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Enzyme Numbers (IUBMB) for QPCT Gene

Gene Ontology (GO) - Molecular Function for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IDA 21288892
GO:0016603 glutaminyl-peptide cyclotransferase activity IDA,IEA 21288892
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with QPCT: view
genes like me logo Genes that share phenotypes with QPCT: view

Animal Models for QPCT Gene

MGI Knock Outs for QPCT:

Animal Model Products

  • Taconic Biosciences Mouse Models for QPCT

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for QPCT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for QPCT Gene

Localization for QPCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for QPCT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for QPCT gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0035580 specific granule lumen TAS --
GO:0070062 extracellular exosome IDA 23376485
GO:1904724 tertiary granule lumen TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with QPCT: view

Pathways & Interactions for QPCT Gene

genes like me logo Genes that share pathways with QPCT: view

Pathways by source for QPCT Gene

3 Reactome pathways for QPCT Gene

Gene Ontology (GO) - Biological Process for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 7999256
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA 21288892
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with QPCT: view

No data available for SIGNOR curated interactions for QPCT Gene

Drugs & Compounds for QPCT Gene

(11) Drugs for QPCT Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Cysteine Approved Nutra 0
N-Acetylhistamine Experimental Pharma Target 0
1-benzylimidazole Experimental Pharma Target 0
Glutamine t-butyl ester Experimental Pharma Target 0
gamma-glutamylcysteine Experimental Pharma 0

(2) Additional Compounds for QPCT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
genes like me logo Genes that share compounds with QPCT: view

Transcripts for QPCT Gene

Unigene Clusters for QPCT Gene

Glutaminyl-peptide cyclotransferase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for QPCT

Alternative Splicing Database (ASD) splice patterns (SP) for QPCT Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: -

Relevant External Links for QPCT Gene

GeneLoc Exon Structure for
QPCT
ECgene alternative splicing isoforms for
QPCT

Expression for QPCT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for QPCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for QPCT Gene

This gene is overexpressed in Whole Blood (x19.6) and Adrenal Gland (x11.4).

Protein differential expression in normal tissues from HIPED for QPCT Gene

This gene is overexpressed in Urine (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for QPCT Gene



NURSA nuclear receptor signaling pathways regulating expression of QPCT Gene:

QPCT

SOURCE GeneReport for Unigene cluster for QPCT Gene:

Hs.79033

Evidence on tissue expression from TISSUES for QPCT Gene

  • Nervous system(4.6)
  • Lung(4.4)
  • Pancreas(4.3)
  • Heart(4.1)
  • Skin(2.4)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with QPCT: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for QPCT Gene

Orthologs for QPCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for QPCT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QPCT 34 35
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia QPCT 34 35
  • 89.01 (n)
dog
(Canis familiaris)
Mammalia QPCT 34 35
  • 88 (n)
rat
(Rattus norvegicus)
Mammalia RGD1562284 34
  • 83.16 (n)
mouse
(Mus musculus)
Mammalia Qpct 34 16 35
  • 82.83 (n)
oppossum
(Monodelphis domestica)
Mammalia QPCT 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QPCT 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves QPCT 34 35
  • 70.71 (n)
lizard
(Anolis carolinensis)
Reptilia QPCT 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qpct 34
  • 65.54 (n)
zebrafish
(Danio rerio)
Actinopterygii qpctlb 34
  • 55.45 (n)
qpct 35
  • 51 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8710 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009673 34
  • 54.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta isoQC 34 35
  • 53.75 (n)
CG5976 36
  • 47 (a)
QC 35
  • 39 (a)
ManyToMany
CG6168 35
  • 35 (a)
ManyToMany
CG32413 35
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea H27A22.1 35
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 29 (a)
OneToMany
-- 37
bread mold
(Neurospora crassa)
Ascomycetes NCU11249 34
  • 44.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToMany
Species where no ortholog for QPCT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QPCT Gene

ENSEMBL:
Gene Tree for QPCT (if available)
TreeFam:
Gene Tree for QPCT (if available)

Paralogs for QPCT Gene

Paralogs for QPCT Gene

(1) SIMAP similar genes for QPCT Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with QPCT: view

Variants for QPCT Gene

Sequence variations from dbSNP and Humsavar for QPCT Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000248057 -- 37,343,123(+) GGAGA(A/T)ACTTA upstream-variant-2KB
rs1000465135 -- 37,368,825(+) AAATT(A/T)GTTGA intron-variant
rs1000614052 -- 37,348,326(+) GCCCG(C/T)ACGGC intron-variant
rs1000722771 -- 37,343,193(+) TTTTG(A/T)ATTGC upstream-variant-2KB
rs1001040740 -- 37,346,317(+) GCCCA(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for QPCT Gene

Variant ID Type Subtype PubMed ID
nsv2685 CNV deletion 18451855
nsv2686 CNV insertion 18451855

Variation tolerance for QPCT Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.19; 90.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for QPCT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
QPCT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for QPCT Gene

Disorders for QPCT Gene

MalaCards: The human disease database

(1) MalaCards diseases for QPCT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pulmonary neuroendocrine tumor
  • neuroendocrine neoplasm of lung
- elite association - COSMIC cancer census association via MalaCards
Search QPCT in MalaCards View complete list of genes associated with diseases

Relevant External Links for QPCT

Genetic Association Database (GAD)
QPCT
Human Genome Epidemiology (HuGE) Navigator
QPCT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
QPCT
genes like me logo Genes that share disorders with QPCT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for QPCT Gene

Publications for QPCT Gene

  1. Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase. (PMID: 7999256) Song I. … Bateman R.C. Jr. (J. Mol. Endocrinol. 1994) 2 3 4 22 64
  2. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis. (PMID: 18072935) Huang K.F. … Wang A.H. (Biochem. J. 2008) 3 4 22 64
  3. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. (PMID: 18486145) Cynis H. … Schilling S. (J. Mol. Biol. 2008) 3 4 22 64
  4. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. (PMID: 16135565) Huang K.-F. … Wang A.H.-J. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 64
  5. Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women. (PMID: 15231017) Ezura Y. … Emi M. (J. Bone Miner. Res. 2004) 3 22 46 64

Products for QPCT Gene

Sources for QPCT Gene

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