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QPCT Gene

protein-coding   GIFtS: 60
GCID: GC02P037571

Glutaminyl-Peptide Cyclotransferase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutaminyl-Peptide Cyclotransferase1 2     EC2 3
Glutaminyl Cyclase1 2 3     sQC2 3
QC2 3 5     EC 2.3.2.53 8
Glutaminyl-TRNA Cyclotransferase2 3     GCT2
Glutamyl Cyclase2 3     

External Ids:    HGNC: 97531   Entrez Gene: 257972   Ensembl: ENSG000001158287   OMIM: 6070655   UniProtKB: Q167693   

Export aliases for QPCT gene to outside databases

Previous GC identifers: GC02P037536 GC02P037718 GC02P037546 GC02P037483 GC02P037425 GC02P037313


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for QPCT Gene:
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl
residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of
bovine glutaminyl cyclase. (provided by RefSeq, Jul 2008)

GeneCards Summary for QPCT Gene:
QPCT (glutaminyl-peptide cyclotransferase) is a protein-coding gene. Diseases associated with QPCT include ascariasis, and trichuriasis. GO annotations related to this gene include peptidase activity and glutaminyl-peptide cyclotransferase activity. An important paralog of this gene is QPCTL.

UniProtKB/Swiss-Prot: QPCT_HUMAN, Q16769
Function: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan
residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second
residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of
N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal
pyroglutamate formation of several amyloid-related plaque-forming peptides

Gene Wiki entry for QPCT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the QPCT gene promoter:
         NF-1   NF-1/L   GATA-3   IRF-1   Tal-1beta   GATA-1   GATA-2   POU2F1   POU2F1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQPCT promoter sequence
   Search Chromatin IP Primers for QPCT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat QPCT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.2   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p22

QPCT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QPCT gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P037571:  view genomic region     (about GC identifiers)

Start:
37,571,717 bp from pter      End:
37,600,465 bp from pter
Size:
28,749 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: QPCT_HUMAN, Q16769 (See protein sequence)
Recommended Name: Glutaminyl-peptide cyclotransferase precursor  
Size: 361 amino acids; 40877 Da
Cofactor: Binds 1 zinc ion per subunit
Selected PDB 3D structures from and Proteopedia for QPCT (see all 21):
1MOI (3D)        2AFM (3D)        2AFO (3D)        2AFS (3D)        2AFU (3D)        2AFW (3D)    
Secondary accessions: Q16770 Q3KRG6 Q53TR4
Alternative splicing: 2 isoforms:  Q16769-1   Q16769-2   

Explore the universe of human proteins at neXtProt for QPCT: NX_Q16769

Explore proteomics data for QPCT at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn49, Asn296
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for QPCT (Q16769) (see all 7)
     GAPNPTF  DDHIPFL  LACHYDSK  GVPVLHLI 


    See QPCT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036545.1  
    ENSEMBL proteins: 
     ENSP00000344829   ENSP00000385391   ENSP00000389227   ENSP00000441606  

    QPCT Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for QPCT

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007484 Peptidase_M28

    Graphical View of Domain Structure for InterPro Entry Q16769

    ProtoNet protein and cluster: Q16769

    UniProtKB/Swiss-Prot: QPCT_HUMAN, Q16769
    Similarity: Belongs to the glutaminyl-peptide cyclotransferase family


    QPCT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QPCT_HUMAN, Q16769
    Function: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan
    residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second
    residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of
    N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal
    pyroglutamate formation of several amyloid-related plaque-forming peptides
    Catalytic activity: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3)

         Enzyme Number (IUBMB): EC 2.3.2.51 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008233peptidase activity IEA--
    GO:0008270zinc ion binding IDA--
    GO:0016603glutaminyl-peptide cyclotransferase activity IDA--
         
    QPCT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for QPCT:
     Increased viability after born 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Qpct):
     behavior/neurological  nervous system  other 

    QPCT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Qpcttm1.2Tbay for QPCT

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for QPCT
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for QPCT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for QPCT

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    2 qRT-PCR Assays for microRNAs that regulate QPCT:
    hsa-miR-29a* hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidQPCT 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: QPCT (NM_012413)
    Sino Biological Human cDNA Clone for QPCT
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QPCT

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    QPCT_HUMAN, Q16769: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    QPCT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for QPCT
    Interactions:

        GeneGlobe Interaction Network for QPCT

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for QPCT (Q167693 ENSP000003448294) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG14Q6ZNE53I2D: score=1 
    CCDC50Q8IVM03I2D: score=1 
    CNBPP626333I2D: score=1 
    ERBB2IPQ96RT13I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS7999256
    GO:0006508proteolysis ----
    GO:0017186peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA--

    QPCT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for QPCT

    4 HMDB Compounds for QPCT    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    Gamma-Glutamylcysteine(Des-Gly)-Glutathione (see all 18)636-58-8--
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--
    Pyroglutamic acid(-)-2-Pyrrolidone-5-carboxylate (see all 65)98-79-3--

    3 DrugBank Compounds for QPCT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-benzylimidazole1-Benzyl-1H-imidazole (see all 2)4238-71-5target----
    Glutamine t-butyl ester-- --target----
    N-ACETYLHISTAMINE-- --target----

    6 Novoseek inferred chemical compound relationships for QPCT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyroglutamate 92.4 16 17005457 (2), 16084398 (1), 1982622 (1), 16135565 (1) (see all 12)
    glutamine 59.9 10 10092499 (2), 14719800 (2), 16820060 (1), 12196024 (1) (see all 5)
    imidazole 54.9 6 14522962 (4), 18570439 (1)
    zinc 44.7 6 15028118 (3), 16084398 (2), 11551224 (1)
    glutamate 35 5 16820060 (1), 15063747 (1), 18979630 (1), 19921850 (1)
    histidine 30.5 4 11551224 (2), 16084398 (1), 10092499 (1)



    QPCT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for QPCT gene: 
    NM_012413.3  

    Unigene Cluster for QPCT:

    Glutaminyl-peptide cyclotransferase
    Hs.79033  [show with all ESTs]
    Unigene Representative Sequence: NM_012413
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338415(uc002rqg.3) ENST00000404976 ENST00000470075 ENST00000480050
    ENST00000469098 ENST00000444022 ENST00000537448

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate QPCT:
    hsa-miR-29a* hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidQPCT 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: QPCT (NM_012413)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for QPCT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QPCT
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for QPCT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat QPCT
      QuantiTect SYBR Green Assays in human, mouse, rat QPCT
      QuantiFast Probe-based Assays in human, mouse, rat QPCT

    Additional mRNA sequence: 

    AB062487.1 AK290605.1 BC015460.1 BC020456.1 BC036721.1 BC047756.2 X67731.1 X71125.1 

    7 DOTS entries:

    DT.92471540  DT.95101779  DT.95101775  DT.95101774  DT.100028509  DT.100782140  DT.91851733 

    Selected AceView cDNA sequences (see all 159):

    BG104484 BU076674 CR608310 BQ676432 AA489708 BF969845 BI859176 BQ436787 
    AV708489 BU179821 BX107292 BF971457 CR620857 CR596088 BM546830 BF724762 
    CR623589 AV705924 AI280994 AA262267 BU072918 BF970452 BQ776785 BG675244 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for QPCT (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                -     -                 -                                       
    SP2:                          -     -     -                 -                                       
    SP3:        -     -     -           -     -                 -                                       
    SP4:                                -                                                               
    SP5:                                -     -     -           -                                       


    ECgene alternative splicing isoforms for QPCT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    QPCT expression in normal human tissues (normalized intensities)      QPCT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTTTGAAG
    QPCT Expression
    About this image


    QPCT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
    QPCT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    QPCT Protein Expression

    Genevestigator expression for QPCT

    SOURCE GeneReport for Unigene cluster: Hs.79033
        Custom PCR Arrays for QPCT
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    QuantiFast Probe-based Assays in human, mouse, rat QPCT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QPCT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for QPCT gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Qpct1 , 5 glutaminyl-peptide cyclotransferase (glutaminyl cyclase)1, 5 82.83(n)1
    82.27(a)1
      17 (49.83 cM)5
    705361  NM_027455.21  NP_081731.11 
     790519065 
    chicken
    (Gallus gallus)
    Aves QPCT1 glutaminyl-peptide cyclotransferase 70.71(n)
    71.82(a)
      421479  XM_004935428.1  XP_004935485.1 
    lizard
    (Anolis carolinensis)
    Reptilia QPCT6
    glutaminyl-peptide cyclotransferase
    56(a)
    1 ↔ 1
    1(235374401-235391934)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX735654.12   -- 76.69(n)    BX735654.1 
    zebrafish
    (Danio rerio)
    Actinopterygii qpctlb1 glutaminyl-peptide cyclotransferase-like b 55.45(n)
    53.27(a)
      564655  XM_001921843.2  XP_001921878.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59763
    isoQC1
    glutaminyl-peptide cyclotransferase3
    iso Glutaminyl cyclase1
    47(a)3
    53.75(n)1
    53.87(a)1
      402701  NM_176372.21  NP_788550.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H27A22.16
    Protein H27A22.1, isoform a (H27A22.1) mRNA, compl...
    35(a)
    1 → many
    V(10602458-10605579) WBGene00010418
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YFR018C)4 Putative protein of unknown function   --   6(184222-183131) 850573  NP_116673.1 


    ENSEMBL Gene Tree for QPCT (if available)
    TreeFam Gene Tree for QPCT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for QPCT gene
    QPCTL2  
    1 SIMAP similar gene for QPCT using alignment to 3 protein entries:     QPCT_HUMAN (see all proteins):
    QPCTL

    QPCT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for QPCT (see all 824)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105581241,2
    C--37445656(+) TGTTT-/TATATAT 1 -- int10--------
    rs1165120061,2
    F--37569761(+) TGTAAA/GAAAAA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1432083501,2
    C--37569772(+) AACCAA/TTGTAT 1 -- us2k10--------
    rs764830881,2
    C,F--37569955(+) AAAGCC/TGCTTG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs37551921,2
    C,F,H--37570031(-) AGACGG/ATCAAA 1 -- us2k120Minor allele frequency- A:0.25NA NS EA WA 2368
    rs67539731,2
    C,F,A,H--37570032(+) TTGACC/GGTCTT 1 -- us2k110Minor allele frequency- G:0.10NS EA NA WA CSA 545
    rs758948101,2
    C,F--37570103(+) TTCTCC/TCTCTG 1 -- us2k11Minor allele frequency- T:0.28WA 118
    rs355760451,2
    C,F--37570179(+) CTGCAG/TGTTAA 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1387971551,2
    C--37570452(+) AGGGT-/AAA   
       AAAAA
    AAAAA
    1 -- us2k10--------
    rs101707611,2
    C,F,A,H--37570538(+) GAGCTG/TTATTG 1 -- us2k114Minor allele frequency- T:0.05NS EA NA WA 1878

    HapMap Linkage Disequilibrium report for QPCT (37571717 - 37600465 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for QPCT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2686CNV Insertion18451855
    nsv2685CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing QPCT
    DNA2.0 Custom Variant and Variant Library Synthesis for QPCT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607065    OMIM disorders: --

    13 diseases for QPCT:    About MalaCards
    ascariasis    trichuriasis    papillary thyroid carcinoma    osteoporosis
    pheochromocytoma    alzheimer's disease    thyroiditis    rheumatoid arthritis
    hypertension    arthritis    melanoma    malaria
    endotheliitis


    QPCT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for QPCT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoporosis 19.9 1 15231017 (1)
    alzheimers disease 18.7 1 19863057 (1)
    tumors 0 2 16820060 (2)

    Genetic Association Database (GAD): QPCT
    Human Genome Epidemiology (HuGE) Navigator: QPCT (3 documents)

    Export disorders for QPCT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for QPCT gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with QPCT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase. (PubMed id 7999256)1, 2, 3, 9 Song I.... Bateman R.C. Jr. (J. Mol. Endocrinol. 1994)
    2. Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women. (PubMed id 15231017)1, 4, 9 Ezura Y....Emi M. (J. Bone Miner. Res. 2004)
    3. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. (PubMed id 18486145)1, 2, 9 Cynis H.... Schilling S. (J. Mol. Biol. 2008)
    4. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis. (PubMed id 18072935)1, 2, 9 Huang K.F.... Wang A.H. (Biochem. J. 2008)
    5. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. (PubMed id 16135565)1, 2, 9 Huang K.-F.... Wang A.H.-J. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    6. Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center. (PubMed id 21671571)1, 2 Ruiz-Carrillo D.... Demuth H.U. (Biochemistry 2011)
    7. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. (PubMed id 21288892)1, 2 Huang K.F....Wang A.H. (J. Biol. Chem. 2011)
    8. The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population. (PubMed id 17687619)1, 4 Huang Q.Y. and Kung A.W. (J. Hum. Genet. 2007)
    9. Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals. (PubMed id 17334644)1, 4 Yamada Y....Shimokata H. (Int. J. Mol. Med. 2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25797 HGNC: 9753 AceView: QPCT Ensembl:ENSG00000115828 euGenes: HUgn25797
    ECgene: QPCT H-InvDB: QPCT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for QPCT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for QPCT gene:
    Search GeneIP for patents involving QPCT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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