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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

QPCT Gene

protein-coding   GIFtS: 57
GCID: GC02P037571

glutaminyl-peptide cyclotransferase
 Explore 13 diseases affiliated with
QPCT via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for QPCT    

Aliases
for QPCT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glutaminyl-Peptide Cyclotransferase1 2     Glutamyl Cyclase2 3
QC1 2 3 5     EC2 3
GCT1 2     SQC1
Glutaminyl Cyclase2 3     EC 2.3.2.53 8
Glutaminyl-TRNA Cyclotransferase2 3     

External Ids:    HGNC: 97531   Entrez Gene: 257972   Ensembl: ENSG000001158287   OMIM: 6070655   UniProtKB: Q167693   

Export aliases for QPCT gene to outside databases

Previous GC identifers: GC02P037536 GC02P037718 GC02P037546 GC02P037483 GC02P037425 GC02P037313


Summaries
for QPCT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for QPCT:
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in
many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl
cyclase. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: QPCT_HUMAN, Q16769
Function: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues
adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also
catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated
form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of
several amyloid-related plaque-forming peptides

Gene Wiki entry for QPCT


Genomic Views
for QPCT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the QPCT gene promoter:
         NF-1   NF-1/L   GATA-3   IRF-1   Tal-1beta   GATA-1   GATA-2   POU2F1   POU2F1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: QPCT promoter sequence
   Search SABiosciences Chromatin IP Primers for QPCT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QPCT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.2   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p22

QPCT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QPCT gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P037571:  view genomic region     (about GC identifiers)

Start:
 37,571,717 bp from pter      End:
 37,600,465 bp from pter
Size:
 28,749 bases      Orientation:
 plus strand

Proteins
for QPCT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: QPCT_HUMAN, Q16769 (See protein sequence)
Recommended Name: Glutaminyl-peptide cyclotransferase precursor  
Size: 361 amino acids; 40877 Da
Cofactor: Binds 1 zinc ion per subunit
Subcellular location: Secreted
6/21 PDB 3D structures from and Proteopedia for QPCT (see all 21):
1MOI (3D)        2AFM (3D)        2AFO (3D)        2AFS (3D)        2AFU (3D)        2AFW (3D)    
Secondary accessions: Q16770 Q3KRG6 Q53TR4
Alternative splicing: 2 isoforms:  Q16769-1   Q16769-2   

Explore the universe of human proteins at neXtProt for QPCT: NX_Q16769

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16769

    • 4/7 DME Specific Peptides for QPCT (Q16769) (see all 7)
     GAPNPTF  DDHIPFL  LACHYDSK  GVPVLHLI 

    QPCT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036545.1  
    ENSEMBL proteins: 
     ENSP00000344829   ENSP00000385391   ENSP00000389227   ENSP00000441606  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for QPCT (Glutaminyl-peptide Cyclotransferase/QPCT)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: QPCT
    OriGene Protein Over-expression Lysate: QPCT
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    Novus Biologicals QPCT Proteins
    Novus Biologicals QPCT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for QPCT

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    QPCT for ontologies           About GeneDecksing



    QPCT Antibody Products: 
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    Uscn Antibodies for QPCT
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    Assay Products for QPCT: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for QPCT

    Protein Domains /
    Families
    for QPCT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    QPCT for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007484 Peptidase_M28

    Graphical View of Domain Structure for InterPro Entry Q16769

    ProtoNet protein and cluster: Q16769

    UniProtKB/Swiss-Prot: QPCT_HUMAN, Q16769
    Similarity: Belongs to the glutaminyl-peptide cyclotransferase family


    Function
    for QPCT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: QPCT_HUMAN, Q16769
    Function: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues
    adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also
    catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated
    form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of
    several amyloid-related plaque-forming peptides
    Catalytic activity: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3)

    Enzyme Number (IUBMB): EC 2.3.2.51 2

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate QPCT:
    hsa-miR-29a* hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmid: QPCT 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for QPCT (see all 4)
    OriGene shRNA RFP: QPCT
    OriGene siRNA: QPCT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QPCT

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for QPCT

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for QPCT (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QPCT 

    Cell Line
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    Search LifeMap BioReagents cell lines for QPCT

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008233peptidase activity IEA--
    GO:0008270zinc ion binding IDA--
    GO:0016603glutaminyl-peptide cyclotransferase activity IDA--


    QPCT for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for QPCT:
     Increased viability after born 

    Animal Models:
         Mouse knock-out Qpcttm1.2Tbay for QPCT
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Qpct):
     behavior/neurological  nervous system  other 

    QPCT for phenotypes           About GeneDecksing


    Pathways & Interactions
    for QPCT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for QPCT

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/24 Interacting proteins for QPCT (Q167693 ENSP000003448294) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG14Q6ZNE53I2D: score=1 
    CCDC50Q8IVM03I2D: score=1 
    CNBPP626333I2D: score=1 
    ERBB2IPQ96RT13I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS7999256
    GO:0006508proteolysis IEA--
    GO:0017186peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA--


    QPCT for ontologies           About GeneDecksing



    Drugs & Compounds
    for QPCT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    QPCT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for QPCT

    4 HMDB Compounds for QPCT    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    Gamma-Glutamylcysteine(Des-Gly)-Glutathione (see all 18)636-58-8--
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--
    Pyroglutamic acid(-)-2-Pyrrolidone-5-carboxylate (see all 65)98-79-3--

    3 DrugBank Compounds for QPCT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-benzylimidazole1-Benzyl-1H-imidazole (see all 2)4238-71-5target----
    Glutamine t-butyl ester-- --target----
    N-ACETYLHISTAMINE-- --target----

    6 Novoseek chemical compound relationships for QPCT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyroglutamate 92.4 16 17005457 (2), 16084398 (1), 1982622 (1), 16135565 (1) (see all 12)
    glutamine 59.9 10 10092499 (2), 14719800 (2), 16820060 (1), 12196024 (1) (see all 5)
    imidazole 54.9 6 14522962 (4), 18570439 (1)
    zinc 44.7 6 15028118 (3), 16084398 (2), 11551224 (1)
    glutamate 35 5 16820060 (1), 15063747 (1), 18979630 (1), 19921850 (1)
    histidine 30.5 4 11551224 (2), 16084398 (1), 10092499 (1)

    Search CenterWatch for drugs/clinical trials and news about QPCT 

    Transcripts
    for QPCT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for QPCT gene: 
    NM_012413.3  

    Unigene Cluster for QPCT:

    Glutaminyl-peptide cyclotransferase
    Hs.79033  [show with all ESTs]
    Unigene Representative Sequence: NM_012413
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338415(uc002rqg.3) ENST00000404976 ENST00000470075 ENST00000480050
    ENST00000469098 ENST00000444022 ENST00000537448

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat QPCT
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate QPCT:
    hsa-miR-29a* hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmid: QPCT 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for QPCT (see all 4)
    OriGene shRNA RFP: QPCT
    OriGene siRNA: QPCT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat QPCT
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for QPCT
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    GenScript: all cDNA clones in your preferred vector: QPCT (NM_012413)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for QPCT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QPCT 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat QPCT
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat QPCT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat QPCT

    Additional cDNA sequence: 

    AB062487.1 AK290605.1 BC015460.1 BC020456.1 BC036721.1 BC047756.2 X67731.1 X71125.1 

    7 DOTS entries:

    DT.92471540  DT.95101779  DT.95101775  DT.95101774  DT.100028509  DT.100782140  DT.91851733 

    24/159 AceView cDNA sequences (see all 159):

    BG104484 AI280994 CR620857 BF724762 CR596088 BI859176 AV705924 CR623589 
    BM546830 CR608310 BU072918 AA262267 BU076674 BF971457 BQ676432 BX107292 
    AV708489 BU179821 BF969845 BQ776785 BQ436787 BF970452 AA489708 BG217293 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for QPCT (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                -     -                 -                                       
    SP2:                          -     -     -                 -                                       
    SP3:        -     -     -           -     -                 -                                       
    SP4:                                -                                                               
    SP5:                                -     -     -           -                                       


    ECgene alternative splicing isoforms for QPCT

    Expression
    for QPCT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    QPCT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGTTTGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    QPCT expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Spinal CordSpinal Floor PlateFloor Plate Cells Neural Ectoderm
    AdiposeVisceral White AdiposeAdipose
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Floor PlateSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium

    See QPCT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for QPCT

    SOURCE GeneReport for Unigene cluster: Hs.79033
        SABiosciences Custom PCR Arrays for QPCT
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QPCT

    Orthologs
    for QPCT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for QPCT gene from 6/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves QPCT1 glutaminyl-peptide cyclotransferase 69.01(n)
    69.5(a)    		   421479  XM_419527.3  XP_419527.2 
    lizard
    (Anolis carolinensis)    		 Reptilia QPCT6
    		 --
    		 62(a)
    		 1 ↔ 1
    		 1(235374916-235391934)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX735654.12   -- 76.69(n)    BX735654.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CR848010.16
    		 --
    		 51(a)
    		 1 ↔ 1
    		 17(42668649-42698188)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG59763
    isoQC1    		 glutaminyl-peptide cyclotransferase3
    iso Glutaminyl cyclase1    		 47(a)3
    53.75(n)1
    53.87(a)1    		   402701  NM_176373.21  NP_788551.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea H27A22.16
    		 --
    		 36(a)
    		 1 → many
    		 V(10602437-10605558)


    ENSEMBL Gene Tree for QPCT (if available)
    TreeFam Gene Tree for QPCT (if available) 

    Paralogs
    for QPCT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for QPCT gene
    QPCTL2  
    1 SIMAP similar gene for QPCT using alignment to 3 protein entries:     QPCT_HUMAN (see all proteins):
    QPCTL

    QPCT for paralogs           About GeneDecksing



    Genomic Variants
    for QPCT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/685 NCBI SNPs in QPCT are shown (see all 685)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1165120061,2
    		F,--37569761(+) TGTAAA/GAAAAA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1432083501,2
    		--37569772(+) AACCAA/TTGTAT 1 -- us2k10--------
    rs764830881,2
    		F,--37569955(+) AAAGCC/TGCTTG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs37551921,2
    		C,F,H,--37570031(-) AGACGG/ATCAAA 1 -- us2k120Minor allele frequency- A:0.25NA NS EA WA 2368
    rs67539731,2
    		C,F,A,H,--37570032(+) TTGACC/GGTCTT 1 -- us2k110Minor allele frequency- G:0.10NS EA NA WA CSA 545
    rs758948101,2
    		C,F,--37570103(+) TTCTCC/TCTCTG 1 -- us2k11Minor allele frequency- T:0.28WA 118
    rs355760451,2
    		C,F,--37570179(+) CTGCAG/TGTTAA 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1387971551,2
    		--37570452(+) AGGGT-/AAA   
       AAAAA    AAAAA     		1 -- us2k10--------
    rs101707611,2
    		C,F,A,H,--37570538(+) GAGCTG/TTATTG 1 -- us2k114Minor allele frequency- T:0.05NS EA NA WA 1878
    rs746992751,2
    		C,F,--37570677(+) TTGTCA/GCTCAA 1 -- us2k12Minor allele frequency- G:0.06WA NA 238

    HapMap Linkage Disequilibrium report for QPCT (37571717 - 37600465 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for QPCT: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing QPCT
    DNA2.0 Custom Variant and Variant Library Synthesis for QPCT

    Disorders / Diseases
    for QPCT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    QPCT for disorders           About GeneDecksing

    OMIM gene information: 607065    OMIM disorders: --

    13 diseases for QPCT:    About MalaCards
    papillary thyroid carcinoma    ascariasis    trichuriasis    osteoporosis
    thyroid carcinoma    alzheimer's disease    rheumatoid arthritis    pheochromocytoma
    thyroiditis    arthritis    hypertension    carcinoma
    melanoma

    3 Novoseek disease relationships for QPCT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoporosis 19.9 1 15231017 (1)
    alzheimers disease 18.7 1 19863057 (1)
    tumors 0 2 16820060 (2)

    Genetic Association Database (GAD): QPCT
    Human Genome Epidemiology (HuGE) Navigator: QPCT (3 documents)

    Export disorders for QPCT gene to outside databases

    Publications
    for QPCT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for QPCT gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with QPCT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase. (PubMed id 7999256)1, 2, 3, 9 Song I.... Bateman R.C. Jr. (1994)
    2. Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women. (PubMed id 15231017)1, 4, 9 Ezura Y....Emi M. (2004)
    3. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. (PubMed id 18486145)1, 2, 9 Cynis H....Schilling S. (2008)
    4. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis. (PubMed id 18072935)1, 2, 9 Huang K.F....Wang A.H. (2008)
    5. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. (PubMed id 16135565)1, 2, 9 Huang K.-F.... Wang A.H.-J. (2005)
    6. Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center. (PubMed id 21671571)1, 2 Ruiz-Carrillo D.... Demuth H.U. (2011)
    7. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. (PubMed id 21288892)1, 2 Huang K.F....Wang A.H. (2011)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity. (PubMed id 12196024)1, 9 Schilling S....Demuth H.U. (2002)
    10. Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators. (PubMed id 14522962)1, 9 Schilling S....Demuth H.U. (2003)

    External Searches for QPCT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing QPCT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25797 HGNC: 9753 AceView: QPCT Ensembl:ENSG00000115828 euGenes: HUgn25797
    ECgene: QPCT H-InvDB: QPCT

    Other Databases showing QPCT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing QPCT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for QPCT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for QPCT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for QPCT gene:
    Search GeneIP for patents involving QPCT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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