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Aliases for QPCT Gene

Aliases for QPCT Gene

  • Glutaminyl-Peptide Cyclotransferase 2 3
  • Glutaminyl Cyclase 2 3 4
  • QC 3 4 6
  • Glutaminyl-TRNA Cyclotransferase 3 4
  • Glutamyl Cyclase 3 4
  • EC 2.3.2.5 4 64
  • SQC 3 4
  • EC 3 4
  • GCT 3

External Ids for QPCT Gene

Summaries for QPCT Gene

Entrez Gene Summary for QPCT Gene

  • This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]

GeneCards Summary for QPCT Gene

QPCT (Glutaminyl-Peptide Cyclotransferase) is a Protein Coding gene. GO annotations related to this gene include peptidase activity and glutaminyl-peptide cyclotransferase activity. An important paralog of this gene is QPCTL.

UniProtKB/Swiss-Prot for QPCT Gene

  • Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Gene Wiki entry for QPCT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for QPCT Gene

Genomics for QPCT Gene

Genomic Location for QPCT Gene

Start:
37,344,574 bp from pter
End:
37,373,322 bp from pter
Size:
28,749 bases
Orientation:
Plus strand

Genomic View for QPCT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for QPCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for QPCT Gene

Regulatory Elements for QPCT Gene

Proteins for QPCT Gene

  • Protein details for QPCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16769-QPCT_HUMAN
    Recommended name:
    Glutaminyl-peptide cyclotransferase
    Protein Accession:
    Q16769
    Secondary Accessions:
    • Q16770
    • Q3KRG6
    • Q53TR4

    Protein attributes for QPCT Gene

    Size:
    361 amino acids
    Molecular mass:
    40877 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for QPCT Gene

    Alternative splice isoforms for QPCT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for QPCT Gene

Proteomics data for QPCT Gene at MOPED

Selected DME Specific Peptides for QPCT Gene

Post-translational modifications for QPCT Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn49 and Asn296

Other Protein References for QPCT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for QPCT Gene

Protein Domains for QPCT Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

QPCT_HUMAN
Family:
  • Belongs to the glutaminyl-peptide cyclotransferase family.:
    • Q16769
genes like me logo Genes that share domains with QPCT: view

No data available for Gene Families for QPCT Gene

Function for QPCT Gene

Molecular function for QPCT Gene

UniProtKB/Swiss-Prot CatalyticActivity: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
UniProtKB/Swiss-Prot Function: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Enzyme Numbers (IUBMB) for QPCT Gene

Gene Ontology (GO) - Molecular Function for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IDA 21288892
GO:0016603 glutaminyl-peptide cyclotransferase activity IDA 21288892
genes like me logo Genes that share ontologies with QPCT: view
genes like me logo Genes that share phenotypes with QPCT: view

Animal Models for QPCT Gene

MGI Knock Outs for QPCT:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for QPCT Gene

Localization for QPCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for QPCT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for QPCT Gene COMPARTMENTS Subcellular localization image for QPCT gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with QPCT: view

Pathways for QPCT Gene

SuperPathways for QPCT Gene

No Data Available

Interacting Proteins for QPCT Gene

Gene Ontology (GO) - Biological Process for QPCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 7999256
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA 21288892
genes like me logo Genes that share ontologies with QPCT: view

No data available for Pathways by source for QPCT Gene

Compounds for QPCT Gene

(4) HMDB Compounds for QPCT Gene

Compound Synonyms Cas Number PubMed IDs
Ammonia
  • NH3
7664-41-7
Gamma-Glutamylcysteine
  • (Des-Gly)-Glutathione
636-58-8
L-Cysteine
  • (+)-2-Amino-3-mercaptopropionic acid
52-90-4
Pyroglutamic acid
  • (-)-2-Pyrrolidone-5-carboxylate
98-79-3

(3) Drugbank Compounds for QPCT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-benzylimidazole
  • 1-Benzyl-1H-imidazole
4238-71-5 target
Glutamine t-butyl ester
target
N-ACETYLHISTAMINE
target

(6) Novoseek inferred chemical compound relationships for QPCT Gene

Compound -log(P) Hits PubMed IDs
pyroglutamate 92.4 13
glutamine 59.9 7
imidazole 54.9 5
zinc 44.7 6
glutamate 35 4
genes like me logo Genes that share compounds with QPCT: view

Transcripts for QPCT Gene

Unigene Clusters for QPCT Gene

Glutaminyl-peptide cyclotransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for QPCT Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: -

Relevant External Links for QPCT Gene

GeneLoc Exon Structure for
QPCT
ECgene alternative splicing isoforms for
QPCT

Expression for QPCT Gene

mRNA expression in normal human tissues for QPCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for QPCT Gene

This gene is overexpressed in Whole Blood (19.6) and Adrenal Gland (11.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for QPCT Gene

SOURCE GeneReport for Unigene cluster for QPCT Gene Hs.79033

genes like me logo Genes that share expressions with QPCT: view

Orthologs for QPCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for QPCT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia QPCT 36
  • 99.26 (n)
  • 99.17 (a)
QPCT 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia QPCT 36
  • 89.01 (n)
  • 86.43 (a)
QPCT 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia QPCT 36
  • 88 (n)
  • 86.43 (a)
QPCT 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Qpct 36
  • 82.83 (n)
  • 82.27 (a)
Qpct 16
Qpct 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia QPCT 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia QPCT 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562284 36
  • 83.16 (n)
  • 83.39 (a)
chicken
(Gallus gallus)
Aves QPCT 36
  • 70.71 (n)
  • 71.82 (a)
QPCT 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia QPCT 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia qpct 36
  • 65.54 (n)
  • 67.79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8710 36
zebrafish
(Danio rerio)
Actinopterygii qpct 37
  • 51 (a)
OneToOne
qpctlb 36
  • 55.45 (n)
  • 53.27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009673 36
  • 54.01 (n)
  • 53.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32413 37
  • 32 (a)
ManyToMany
CG6168 37
  • 35 (a)
ManyToMany
isoQC 36
  • 53.75 (n)
  • 53.87 (a)
isoQC 37
  • 42 (a)
ManyToMany
QC 37
  • 39 (a)
ManyToMany
CG5976 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea H27A22.1 37
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 29 (a)
OneToMany
-- 39
bread mold
(Neurospora crassa)
Ascomycetes NCU11249 36
  • 44.79 (n)
  • 42.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToMany
Species with no ortholog for QPCT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for QPCT Gene

ENSEMBL:
Gene Tree for QPCT (if available)
TreeFam:
Gene Tree for QPCT (if available)

Paralogs for QPCT Gene

Paralogs for QPCT Gene

Selected SIMAP similar genes for QPCT Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with QPCT: view

Variants for QPCT Gene

Sequence variations from dbSNP and Humsavar for QPCT Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10724 -- 37,373,149(+) TTTCT(A/C)AACAG utr-variant-3-prime
rs1468816 -- 37,368,553(-) ATTTG(G/T)ACTTT intron-variant
rs2058718 -- 37,356,654(-) TAAAC(C/G)ATCAA intron-variant
rs2058719 -- 37,356,478(-) CTAAA(A/G)CAGCT intron-variant
rs2230299 -- 37,352,794(+) AATTA(A/C/T)CACCA stop-gained, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for QPCT Gene

Variant ID Type Subtype PubMed ID
nsv2685 CNV Loss 18451855
nsv2686 CNV Insertion 18451855

Relevant External Links for QPCT Gene

HapMap Linkage Disequilibrium report
QPCT

Disorders for QPCT Gene

(3) Novoseek inferred disease relationships for QPCT Gene

Disease -log(P) Hits PubMed IDs
osteoporosis 19.9 1
alzheimers disease 18.7 1
tumors 0 2

Relevant External Links for QPCT

Genetic Association Database (GAD)
QPCT
Human Genome Epidemiology (HuGE) Navigator
QPCT
genes like me logo Genes that share disorders with QPCT: view

No data available for UniProtKB/Swiss-Prot for QPCT Gene

Publications for QPCT Gene

  1. Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase. (PMID: 7999256) Song I. … Bateman R.C. Jr. (J. Mol. Endocrinol. 1994) 2 3 4 23
  2. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. (PMID: 16135565) Huang K.-F. … Wang A.H.-J. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  3. Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women. (PMID: 15231017) Ezura Y. … Emi M. (J. Bone Miner. Res. 2004) 3 23 49
  4. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. (PMID: 18486145) Cynis H. … Schilling S. (J. Mol. Biol. 2008) 3 4 23
  5. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis. (PMID: 18072935) Huang K.F. … Wang A.H. (Biochem. J. 2008) 3 4 23

Products for QPCT Gene

Sources for QPCT Gene

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