V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

QKI Gene

protein-coding GIFtS: 57

GC06P163806

quaking homolog, KH domain RNA binding (mouse)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp586I0923 ^²
HKQ ^³
Hqk ^², ³
HqkI ^³
OTTHUMP00000017581 ^²
OTTHUMP00000017582 ^²
OTTHUMP00000017583 ^²
QK ^²
QK1 ^²
QK3 ^¹, ²

Descriptions
RNA binding protein HQK ^²
homolog of mouse quaking QKI (KH domain RNA binding protein) ^²
quaking homolog, KH domain RNA binding ^²
quaking homolog, KH domain RNA binding (mouse) ^²

External Ids
HGNC: 21100¹
Entrez Gene: 9444²
UniProtKB: Q96PU8³
Ensembl: ENSG00000112531⁷

Search outside databases for aliases for QKI gene

Previous GC identifers: GC06P163188 GC06P163709 GC06P163689 GC06P163728

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for QKI:

QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH)

domain embedded in a 200-amino acid region called the GSG domain. Other members of this family

include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed

9671495]). QKI proteins regulate RNA splicing, export of target RNAs from the nucleus, translation

of proteins, and RNA stability (Lauriat et al., 2008 [PubMed 17918747]).[supplied by OMIM]

UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8

Function: RNA-binding protein that plays a central role in myelinization. Binds to the

5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export,

mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as

MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by

regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG

pre-mRNA. Acts as a translational repressor (By similarity)

Gene Wiki entry for QKI

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the QKI gene

Entrez Gene cytogenetic band: 6q26|6q26-q27 Ensembl cytogenetic band: 6q26 HGNC cytogenetic band: 6q26

QKI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P163806: (about GC identifiers)

Start:	163,755,665 bp from pter
End:	163,914,886 bp from pter
Size:	159,222 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007422.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8 (See protein sequence)

Recommended Name: Protein quaking

Size: 341 amino acids; 37671 Da

Subunit: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By

similarity)

Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity)

Sequence caution: Sequence=AAF63412.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;

Sequence=AAF63415.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA; Sequence=AAF63416.1;

Type=Miscellaneous discrepancy; Note=Chimeric cDNA;

Secondary accessions: Q2I375 Q5MJQ1 Q969L9 Q96EJ3 Q96KA3 Q96PU6 Q96PU7 Q9P0X6 Q9P0X7 Q9P0X8 Q9P0X9

Q9P0Y0 Q9P0Y1

Alternative splicing: 8 isoforms: Q96PU8-1 Q96PU8-2 Q96PU8-3 Q96PU8-4 Q96PU8-5 Q96PU8-6 Q96PU8-7 Q96PU8-8

Post-translational modifications:

Methylated by PRMT1 (By similarity)¹

Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased

mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity)¹

REFSEQ proteins (4 alternative transcripts):

NP_006766.1 NP_996735.1 NP_996736.1 NP_996737.1

ENSEMBL proteins:

ENSP00000375976 ENSP00000355094 ENSP00000354951 ENSP00000354867 ENSP00000275262 ENSP00000375973

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (QK1)
	Human Recombinant Proteins from Abnova (QKI)

OriGene Purified Recombinant Human Proteins (see all 3): QKI

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for QKI:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of QKI
	Sigma-Aldrich Antibodies for QKI
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (QK1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (QKI)
	Novus Biologicals Antibodies for QKI

Assays for QKI:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96PU8

ProtoNet protein and cluster: Q96PU8

2 Blocks protein families:

IPB004087 KH domain

IPB004088 KH

UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8

Similarity: Contains 1 KH domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QKI)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (QKI)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): XM_037438

Applied Biosystems Silencer® siRNAs for QKI

Sigma-Aldrich siRNA for QKI

Sigma-Aldrich shRNA for QKI

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for QKI
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_006775
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_006775
untagged cDNA clones in CMV expression vector (see all 4): NM_006775

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006775

UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8

Function: RNA-binding protein that plays a central role in myelinization. Binds to the

5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export,

mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as

MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by

regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG

pre-mRNA. Acts as a translational repressor (By similarity)

13 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Qk):

	behavior/neurological	embryogenesis	growth/size	hearing/vestibular/ear
hematopoietic system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail
muscle	nervous system	reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	16713569
GO:0017124	SH3 domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/27 Interacting proteins for QKI (ENSP00000355094³ Q96PU8^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 27 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000078328	Q9NWB1¹^,²	EBI-945792, EBI-945906 MINT-2855822 MINT-2866408
FOX1	Q9NWB1¹^,²	EBI-945792, EBI-945906 MINT-2855822 MINT-2866408
HNRNPK	P61978¹^,²	STRING (score=.77) EBI-945792, EBI-304185 MINT-2855592 MINT-2859777 EBI-945792, EBI-304185 MINT-2855592 MINT-2859777
PCBP1	Q15365¹^,²	EBI-945792, EBI-946095 MINT-2866427 MINT-2856312 EBI-945792, EBI-946095 MINT-2866427 MINT-2856312
PTBP1	P26599¹^,²	EBI-945792, EBI-350540 MINT-2855611 MINT-2862237 EBI-945792, EBI-350540 MINT-2855611 MINT-2862237

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006397	mRNA processing	IEA	--
GO:0006417	regulation of translation	IEA	--
GO:0006810	transport	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0008380	RNA splicing	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for QKI

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QKI)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (QKI)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): XM_037438

Sigma-Aldrich siRNA for QKI

Sigma-Aldrich shRNA for QKI

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006775 NM_206853 NM_206854 NM_206855

REFSEQ mRNAs for QKI gene (4 alternative transcripts):

NM_006775.1 NM_206853.1 NM_206854.1 NM_206855.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006775 NM_206853 NM_206854 NM_206855

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_006775
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_006775
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_006775

Additional cDNA sequence: AK096701.1

24/33 DOTS entries (see all 33 ):

DT.454551 DT.101973994 DT.95256589 DT.100798534 DT.121644952 DT.444196 DT.100798531 DT.206927

DT.212668 DT.100798536 DT.97781562 DT.426724 DT.100798532 DT.121391671 DT.92439646 DT.100798527

DT.121391768 DT.95137009 DT.91641735 DT.100798529 DT.92439628 DT.100889285 DT.121391627 DT.121391760

24/580 AceView cDNA sequences (see all 580 ):

BQ005442 AL118610 BF198125 BU507882 BF592851 W02744 AI140409 AA412385

CB155403 AL119689 BF445783 AB067801 AW512022 AW009668 AB067800 AF272349

AL596541 CR611372 BM672054 BF439537 AW513028 AI498917 BE466275 BF060766

highest scoring ESTs for QKI:

AA002101 AA002102 AA090044 AA102572 AA149507 AA215424 AA255504 AA279636 AA280004 AA284979

Unigene Clusters for QKI:

Quaking homolog, KH domain RNA binding (mouse)

Hs.510324 [show with all ESTs], Hs.593520 [show with all ESTs]

Unigene Representative Sequences: NM_206855, AK096701

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for QKI (see all 10 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11a	·	11b	^	12a	·	12b
SP1:							-						-																		-		-		-
SP2:							-						-
SP3:							-						-												-
SP4:																									-						-		-		-
SP5:													-		-																-		-		-

About this scheme

ECgene alternative splicing isoforms for QKI

6 Ensembl transcripts including schematic representations:

ENST00000392130 ENST00000361752 ENST00000361758 ENST00000361195 ENST00000275262 ENST00000392127

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

QKI expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for QKI

¹ / ² / ³

20 probe-sets matching QKI gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
74289_at²^{, 3}	U95-D	1	1.00	1.00	0.92	0.84	AW009668	0.40	1.00	0.76	1
39759_at²^{, 3}	U95-A	1	1.00	1.00	0.24	1.06	AL031781	0.20	1.00	0.72	1
66100_s_at²^{, 3}	U95-C	1	1.00	1.00	0.94	0.87	AW016430	0.80	1.00	0.91	1
39760_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.18	AL031781	0.20	1.00	0.72	1
45656_at²^{, 3}	U95-B	1	0.94	1.00	0.88	1.15	AI633884	0.40	1.00	0.76	1
214541_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF142418	0.40	1.00	0.76	1
212262_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA149639	0.60	1.00	0.82	1
212636_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL031781	0.20	1.00	0.72	1
228540_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE218313	0.20	1.00	0.72	1
212265_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL031781	0.20	1.00	0.72	1
212263_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI114716	0.80	1.00	0.91	1
214543_x_at²^{, 3}	U133-A	1	0.73	1.00	--	--	AF142421	0.40	1.00	0.76	1
214541_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212262_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212636_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228540_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212265_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212263_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555154_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214543_x_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

GeneDecks QKI for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.510324 Hs.593520
Expression variation in blood from EXPOLDB for QKI
UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8
Tissue specificity: Expressed in the frontal cortex of brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for QKI gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	QKI¹	--	quaking homolog, KH domain RNA binding (mouse)	95.96(n) 99.33(a)	606754 XM_850463.1 XP_855556.1
cow (Bos taurus)	QKI¹	--	quaking homolog, KH domain RNA binding (mouse)	95.8(n) 100(a)	493722 NM_001007817.1 NP_001007818.1
rat (Rattus norvegicus)	Qk¹	--	quaking	95.6(n) 99.4(a)	499022 XM_574316.2 XP_574316.2
mouse (Mus musculus)	Qk^{1, 5}	17 (5.90 cM)⁵	quaking^{1, 5}	96.03(n)¹ 100(a)¹	19317¹ NM_021881.1¹ NP_068681.1¹ AA210530⁵ AC090656⁵ (see all 47)
chicken (Gallus gallus)	QKI¹	--	quaking homolog, KH domain RNA binding (mouse)	89.62(n) 97.81(a)	374204 NM_204310.1 NP_989641.1

About this table Species with no ortholog for QKI

ENSEMBL Gene Tree for QKI

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for QKI gene

SF1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/918 NCBI SNPs in QKI are shown (see all 918 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 293)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs715020^1,2	A,C,F,H,O	163906472(-)	`TCTTAC/TTCATT`	4	--	ut3¹ int¹ ese³		9	MN EU EA WA NA	2314
	rs2057003^1,2	C,F,H,O	163914946(-)	`GTCACG/ACTATG`	1	--	ng3¹		8	MN EU EA WA NA	738
--	rs9784871^1,2	C,F,H	163913172(+)	`TTCCAA/GTCTTC`	1	--	ut3¹		4	EU EA WA	418
	rs3756879^1,2	C,F,H	163910298(+)	`TCTAAA/TTGATA`	4	--	ut3¹ int¹		12	EU EA WA NA	1046
	rs9456869^1,2	A,F,H	163907379(+)	`TTGTCA/TGTATT`	4	--	int¹ ut3¹		8	EU EA WA	836
	rs9347766^1,2	A,H	163904956(+)	`ACTGAG/CGTTCA`	4	--	int¹ ut3¹		4	EU EA WA	404
	rs16895118^1,2	F,H	163905019(+)	`ACATTA/GCTGAG`	4	--	int¹ ut3¹		7	NA EU EA WA	558
	rs6936664^1,2	F,H	163909408(+)	`TTTTAT/CTGTAT`	4	--	int¹ ut3¹		4	EU EA WA	416
	rs3777901^1,2	F,H	163906371(+)	`CTGGGG/ACTCTT`	4	--	ut3¹ int¹ ese³		5	EA EU WA	1908
	rs2294699^1,2	F,H	163909447(-)	`ACAAAA/GGATCC`	4	--	ut3¹ int¹		5	EA EU WA	1516

About this table

HapMap Linkage Disequilibrium images for QKI (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609590

UniProtKB/Swiss-Prot: QKI_HUMAN, Q96PU8

May play a role in genetic susceptibility to schizophrenia. QKI levels of some isoforms

such as isoform 6, are frequently down-regulated in schizophrenic patients

Deletion of the QKI gene may play a role in astrocytic tumors

Human Genome Epidemiology Navigator: QKI (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/34 PubMed articles for QKI gene (see all 34 ):

Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia. (PubMed id 16641098)^{3, 4} Aberg K.... Jazin E. (2006)
Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH. (PubMed id 16205629)^{3, 4} Ichimura K.... Collins V.P. (2006)
Human QKI, a new candidate gene for schizophrenia involved in myelination. (PubMed id 16342280)^{3, 4} Aeberg K.... Jazin E. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Expression of Hqk encoding a KH RNA binding protein is altered in human glioma. (PubMed id 11856480)^{3, 4} Li Z.Z.... Abe K. (2002)
The STAR protein QKI-6 is a translational repressor. (PubMed id 10535969)^{2, 3} Saccomanno L....Goodwin E.B. (1999)
The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia. (PubMed id 17012699)^{1, 3} Haroutunian V....Davis K.L. (2006)
No association found between the promoter variations of QKI and schizophrenia in the Chinese population. (PubMed id 18938205)³ Huang K....Shi Y. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9444	HGNC: 21100	AceView: QKI	Ensembl:ENSG00000112531	euGenes: HUgn9444
ECgene: QKI	H-InvDB: QKI

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for QKI
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for QKI:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for QKI-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for QKI		Antibodies for QKI
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for QKI		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (QKI)
	Antibodies (QKI)
	Chimera RNAi (QKI)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (QK1)
	Antibodies (QK1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for QKI

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for QKI

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
QKI Gene at Home site.
Version 2.41.1
server5.xennexinc.com

QKI Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for QKI

Summaries
for QKI

Genomic Location
for QKI

Proteins
for QKI

Protein Domains/
Families
for QKI

Gene Function
for QKI

Pathways & Interactions
for QKI

Drugs & Compounds
for QKI

Transcripts
for QKI

Expression
for QKI

Orthologs
for QKI

Paralogs
for QKI

SNPs/Variants
for QKI

Disorders & Mutations
for QKI

Medical News
for QKI

Publications
for QKI

Search for QKI

Genome Databases showing QKI

Other Databases showing QKI

Specialized Databases showing QKI

Licensable Technologies
for QKI

Services
for QKI

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

QKI Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor QKI

Summariesfor QKI

Genomic Locationfor QKI

Proteinsfor QKI

Protein Domains/Familiesfor QKI

Gene Functionfor QKI

Pathways & Interactionsfor QKI

Drugs & Compoundsfor QKI

Transcriptsfor QKI

Expression for QKI

Orthologsfor QKI

Paralogsfor QKI

SNPs/Variantsfor QKI

Disorders & Mutationsfor QKI

Medical Newsfor QKI

Publicationsfor QKI

Search for QKI

Genome Databases showing QKI

Other Databases showing QKI

Specialized Databases showing QKI

Licensable Technologiesfor QKI

Servicesfor QKI

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for QKI

Summaries
for QKI

Genomic Location
for QKI

Proteins
for QKI

Protein Domains/
Families
for QKI

Gene Function
for QKI

Pathways & Interactions
for QKI

Drugs & Compounds
for QKI

Transcripts
for QKI

Expression
for QKI

Orthologs
for QKI

Paralogs
for QKI

SNPs/Variants
for QKI

Disorders & Mutations
for QKI

Medical News
for QKI

Publications
for QKI

Licensable Technologies
for QKI

Services
for QKI