Aliases for QKI Gene
External Ids for QKI Gene
Previous GeneCards Identifiers for QKI Gene
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for QKI Gene
QKI (QKI, KH Domain Containing, RNA Binding) is a Protein Coding gene. Diseases associated with QKI include 6Q Terminal Deletion Syndrome and Schizophrenia. Among its related pathways are Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is KHDRBS1.
UniProtKB/Swiss-Prot for QKI Gene
RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5-NACUAAY-N(1,20)-UAAY-3 RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).