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QDPR Gene

protein-coding GIFtS: 62

GC04M017097

quinoid dihydropteridine reductase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DHPR ^¹, ², ³, ⁵
EC 1.5.1.34 ^³
FLJ42391 ^²
HDHPR ^³
PKU2 ^¹, ²
SDR33C1 ^¹, ²

Descriptions
6,7-dihydropteridine reductase ^²
quinoid dihydropteridine reductase ^², ³
short chain dehydrogenase/reductase family 33C, member 1 ^²

External Ids
HGNC: 9752¹
Entrez Gene: 5860²
UniProtKB: P09417³
Ensembl: ENSG00000151552⁷

Search outside databases for aliases for QDPR gene

Previous GC identifers: GC04M017302 GC04M017430 GC04M017176 GC04M017238 GC04M017164

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for QDPR:

This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated

reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the

pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in

QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature

terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to

insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by

RefSeq]

UniProtKB/Swiss-Prot: DHPR_HUMAN, P09417

Function: The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for

phenylalanine, tyrosine, and tryptophan hydroxylases

Gene Wiki entry for QDPR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the QDPR gene

Entrez Gene cytogenetic band: 4p15.31 Ensembl cytogenetic band: 4p15.32 HGNC cytogenetic band: 4p15.31

QDPR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M017097: (about GC identifiers)

Start:	17,097,121 bp from pter
End:	17,154,822 bp from pter
Size:	57,702 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_006316.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DHPR_HUMAN, P09417 (See protein sequence)

Recommended Name: Dihydropteridine reductase

Size: 244 amino acids; 25790 Da

Subunit: Homodimer

PDB structures from and Proteopedia :

1HDR (3D)

Secondary accessions: Q53F52 Q9H3M5

REFSEQ proteins: NP_000311.2

ENSEMBL proteins:

ENSP00000281243

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (QDPR)
	Human Recombinant Proteins from Abnova (QDPR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11256614

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Antibodies for QDPR:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for QDPR
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (QDPR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (QDPR)
	Novus Biologicals Antibodies for QDPR

Assays for QDPR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P09417

ProtoNet protein and cluster: P09417

1 Blocks protein family: IPB002198 Short-chain dehydrogenase/reductase SDR

UniProtKB/Swiss-Prot: DHPR_HUMAN, P09417

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QDPR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (QDPR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC000576

Applied Biosystems Silencer® siRNAs for QDPR

Sigma-Aldrich siRNA and siRNA Panels for QDPR

Sigma-Aldrich shRNA for QDPR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for QDPR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000320
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000320
untagged cDNA clones in CMV expression vector (see all 2): BC000576

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000320

UniProtKB/Swiss-Prot: DHPR_HUMAN, P09417

Function: The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for

phenylalanine, tyrosine, and tryptophan hydroxylases

Catalytic activity: A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H

Enzyme Number (IUBMB): EC 1.5.1.34

Genatlas biochemistry entry for QDPR:

quininoid dihydropteridine reductase,tetrahydrobiopterin (BH4) cycle,phenylalanine hydroxylation

system

1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Qdpr):

skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004155	6,7-dihydropteridine reductase activity	TAS	3033643
GO:0005488	binding	IEA	--
GO:0009055	electron carrier activity	TAS	3033643
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for QDPR (Your Favorite Gene powered by Ingenuity)

Dopamine Receptor Signaling
Serotonin Receptor Signaling
Folate Biosynthesis

GeneDecks QDPR for the pathways selected above

About GeneDecksing

5/14 Interacting proteins for QDPR (ENSP00000281243³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAH	ENSP00000303500³	STRING (score=.998)
PCBD1	ENSP00000299299³	STRING (score=.99)
RYR1	ENSP00000352608³	STRING (score=.953)
TRDN	ENSP00000354307³	STRING (score=.95)
ENSG00000188985	ENSP00000343033³	STRING (score=.897)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006520	amino acid metabolic process	TAS	3033643
GO:0006559	L-phenylalanine catabolic process	IEA	--
GO:0006729	tetrahydrobiopterin biosynthetic process	IEA	--
GO:0051066	dihydrobiopterin metabolic process	TAS	3033643
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for QDPR
10/31 Novoseek chemical compound relationships for QDPR gene (see all 31 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dihydropteridine	99.32	214	12956422 (4), 2116088 (4), 1861459 (4), 9796752 (3) (see all 99)
6-pyruvoyltetrahydropterin	94.40	20	16917893 (2), 1754298 (1), 11694255 (1), 12003346 (1) (see all 13)
7-biopterin	89.03	2	7923811 (1)
ryanodine	88.12	47	11412150 (2), 15505226 (2), 8755610 (1), 10760701 (1) (see all 39)
pterin	86.08	22	12956422 (2), 1754298 (1), 1289568 (1), 8819618 (1) (see all 12)
sepiapterin	81.75	14	16917893 (2), 12003346 (1), 17188538 (1), 2039522 (1) (see all 7)
dihydrobiopterin	79.74	5	1956581 (1), 7609464 (1), 11153907 (1)
pteridine	78.72	7	1886401 (1), 10484807 (1), 16116247 (1), 2039522 (1) (see all 7)
6-biopterin	77.45	1	7945390 (1)
phenylalanine	77.18	35	2069475 (2), 8433887 (2), 1754298 (1), 1289568 (1) (see all 17)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (QDPR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (QDPR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC000576

Sigma-Aldrich siRNA and siRNA Panels for QDPR

Sigma-Aldrich shRNA for QDPR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000320

REFSEQ mRNAs for QDPR gene:

NM_000320.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000320

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000320
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000320
                                 untagged cDNA clones in CMV expression vector (see all 2): BC000576

Additional cDNA sequence:

AK094546.1 AK095167.1 AK124382.1 AK124952.1 AK223437.1 AK289773.1 AK296622.1 BC000576.2

BC036878.1 CR591242.1 CR595211.1 CR596771.1 CR602964.1 CR608945.1 CR614918.1 CR617908.1

CR622555.1 CR624599.1 M16447.1 X04882.1

24/32 DOTS entries (see all 32 ):

DT.316605 DT.40250555 DT.100824314 DT.100824324 DT.86854894 DT.92449037 DT.100021950 DT.92449039

DT.121240196 DT.95250989 DT.100824315 DT.121255922 DT.95236053 DT.100824306 DT.100824310 DT.121240152

DT.99968607 DT.121240128 DT.100824320 DT.100824323 DT.70102666 DT.121240155 DT.95185917 DT.95185953

24/451 AceView cDNA sequences (see all 451 ):

BF971916 BU788153 BE046197 BU162546 BU158225 BM710428 BM797202 BI711698

BM760507 BF971542 CA942431 AI144281 BG752102 CR595211 BQ643721 BU727827

BU553814 CR602964 CA868592 BQ267353 CA443385 CR624599 BQ879051 AA488323

highest scoring ESTs for QDPR:

M16447 AA057300 AW328417 AW607121 BC000576 BE254566 BE255699 BE255723 BE261182 BE263218

Unigene Cluster for QDPR:

Quinoid dihydropteridine reductase

Hs.75438 [show with all ESTs]

Unigene Representative Sequence: AK124952

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for QDPR (see all 13 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f	·	9g
SP1:									-										-						-								-
SP2:																			-						-								-
SP3:																			-						-		-
SP4:									-										-						-		-						-
SP5:									-		-		-						-						-								-

About this scheme

ECgene alternative splicing isoforms for QDPR

1 Ensembl transcript including schematic representation:

ENST00000281243

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

QDPR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for QDPR

¹ / ² / ³

3 probe-sets matching QDPR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
260_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M16447	1.00	1.00	1.00	1
209123_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000576	0.80	1.00	0.91	1
209123_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks QDPR for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATTGCTGGA

SOURCE GeneReport for Unigene cluster: Hs.75438
Expression variation in blood from EXPOLDB for QDPR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for QDPR gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	QDPR¹	--	quinoid dihydropteridine reductase	89.9(n) 95.85(a)	479082 XM_536229.2 XP_536229.2
chimpanzee (Pan troglodytes)	QDPR¹	--	quinoid dihydropteridine reductase	98.91(n) 97.54(a)	745779 XM_001161997.1 XP_001161997.1
cow (Bos taurus)	QDPR¹	--	quinoid dihydropteridine reductase	87.03(n) 92.89(a)	618084 NM_001076492.1 NP_001069960.1
rat (Rattus norvegicus)	Qdpr¹	--	quinoid dihydropteridine reductase	87.22(n) 95(a)	64192 NM_022390.1 NP_071785.1
mouse (Mus musculus)	Qdpr^{1, 5}	5 (30.00 cM)⁵	quinoid dihydropteridine reductase^{1, 5}	88.33(n)¹ 93.75(a)¹	110391¹ NM_024236.1¹ NP_077198.1¹ AI325507⁵ AI845337⁵ (see all 15)

About this table Species with no ortholog for QDPR

ENSEMBL Gene Tree for QDPR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/375 NCBI SNPs in QDPR are shown (see all 375 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 119)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1031327^1,2	A,C,F,H,O	17097342(+)	`GACACA/GGGGCA`	1	--	ut3¹ ese³		13	MN EA NA EU WA	1894
	rs1031326^1,2	A,C,F,H,O	17097162(+)	`CCTTCC/TGAGAA`	1	--	ut3¹ ese³		5	MN EU EA WA	602
	rs699459^1,2	A,C,F,H	17097170(+)	`GAACAC/TCAGAT`	1	--	ut3¹ ese³		8	MN NA EU EA WA	722
	rs10604^1,2	A,C,F,H	17097230(-)	`TCTTAT/CATACA`	1	--	ut3¹ ese³		13	MN NA EU EA WA	1352
--	rs6843189^1,2	A,C,F,H	17155479(+)	`TTTCCC/TCTGGA`	1	--	ng3¹		4	EU EA WA	418
--	rs1049581^1,2	A,C,F,H	17097632(-)	`TCCGTC/TGATCT`	1	--	ut3¹		5	MN EU EA WA	594
	rs1049600^1,2	A,C,F,H	17097449(-)	`ATGTCA/GTAGAC`	1	--	ut3¹ ese³		12	MN NA EU EA WA	1138
--	rs9994673^1,2	A,C,F,H	17156328(+)	`GTCAGT/CGATAG`	1	--	ng3¹		8	EU EA WA	836
	rs1049601^1,2	A,C,F,H	17097444(-)	`ATAGAC/TGTAGT`	1	--	ut3¹ ese³		8	MN NA EU EA WA	722
--	rs2518628^1,2	A,C,F,H	17154903(-)	`TATAGA/CCATTA`	1	--	ng3¹		4	EU EA WA	416

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HapMap Linkage Disequilibrium images for QDPR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 612676 disorders: 261630

UniProtKB/Swiss-Prot: DHPR_HUMAN, P09417

Defects in QDPR are the cause of phenylketonuria II (PK2) [MIM:261630]; also known as

dihydropteridine reductase deficiency. PK2 is a rare autosomal recessive disorder characterized by

hyperphenylalaninemia and severe neurologic symptoms (malignant hyperphenylalaninemia) including

axial hypotonia and truncal hypertonia, abnormal thermogenesis, and microcephaly. These signs are

attributable to depletion of the neurotransmitters dopamine and serotonin, whose syntheses are

controlled by tryptophan and tyrosine hydroxylases that use BH-4 as cofactor. These patients do

not respond to phenylalanine-restricted diet. PK2 is lethal if untreated

10/17 Novoseek disease relationships for QDPR gene (see all 17 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperphenylalaninemia	94.84	21	10384371 (1), 12003346 (1), 14705166 (1), 9075022 (1) (see all 16)
phenylketonuria atypical	84.51	2	7760062 (1), 12637773 (1)
phenylketonuria classical	80.97	6	8819618 (1), 16767663 (1), 8222274 (1), 8404969 (1)
phenylketonurias	80.05	9	1754298 (1), 1289568 (1), 8819618 (1), 1745643 (1) (see all 8)
gtp cyclohydrolase i deficiency	76.56	2	16275037 (1), 8830181 (1)
enzyme deficiency	53.54	1	12003346 (1)
hypokalemic periodic paralysis	48.16	2	10944223 (1), 15336973 (1)
mental retardation	36.70	2	19099731 (1)
myopathy	19.62	2	9199776 (1), 15336973 (1)
vitiligo	18.61	2	15009710 (2)

About this table

Genatlas disease: QDPR

hyperphenylalaninemia,malignant phenylketonuria with neurologic deterioration

Human Gene Mutation Database: QDPR
Human Genome Epidemiology Navigator: QDPR (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/227 PubMed articles for QDPR gene (see all 227 ):

Molecular analysis of 16 Turkish families with DHPR deficiency using denaturing gradient gel electrophoresis (DGGE). (PubMed id 11153907)^{1, 3, 4} Romstad A.... Guettler F. (2000)
Dihydropteridine reductase deficiency: physical structure of the QDPR gene, identification of two new mutations and genotype-phenotype correlations. (PubMed id 9744478)^{1, 3, 4} Dianzani I.... Cotton R.G.H. (1998)
A series of mutations in the dihydropteridine reductase gene resulting in either abnormal RNA splicing or DHPR protein defects. (PubMed id 10408783)^{1, 3, 4} Smooker P.M....Dianzani I. (1999)
Molecular basis of dihydropteridine reductase deficiency. (PubMed id 7627180)^{1, 3, 4} Smooker P.M. and Cotton R.G.H. (1995)
Insertion of an extra codon for threonine is a cause of dihydropteridine reductase deficiency. (PubMed id 2116088)^{1, 3, 4} Howells D.W.... Cotton R.G.H. (1990)
Two new mutations in the dihydropteridine reductase gene in patients with tetrahydrobiopterin deficiency. (PubMed id 8326489)^{1, 3, 4} Dianzani I....Cotton R.G.H. (1993)
The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue. (PubMed id 8262916)^{1, 3, 4} Su Y....Whiteley J.M. (1993)
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)^{2, 3} Persson B....Oppermann U. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Human dihydropteridine reductase: characterisation of a cDNA clone and its use in analysis of patients with dihydropteridine reductase deficiency. (PubMed id 3031582)^{3, 4} Dahl H.-H.M....Cotton R.G.H. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5860	HGNC: 9752	AceView: QDPR	Ensembl:ENSG00000151552	euGenes: HUgn5860
ECgene: QDPR	H-InvDB: QDPR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
BIOMDB	http://www.bh4.org/biodef1.html
GeneReviews	http://www.genetests.org/query?gene=QDPR

Licensable Technologies for QDPR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for QDPR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for QDPR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for QDPR		Antibodies for QDPR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for QDPR		Browse small molecules at Sigma-Aldrich
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	Recombinant Proteins (QDPR)
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Antibodies for QDPR

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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QDPR Gene at Home site.
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QDPR Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for QDPR

Summaries
for QDPR

Genomic Location
for QDPR

Proteins
for QDPR

Protein Domains/
Families
for QDPR

Gene Function
for QDPR

Pathways & Interactions
for QDPR

Drugs & Compounds
for QDPR

Transcripts
for QDPR

Expression
for QDPR

Orthologs
for QDPR

Paralogs
for QDPR

SNPs/Variants
for QDPR

Disorders & Mutations
for QDPR

Medical News
for QDPR

Publications
for QDPR

Search for QDPR

Genome Databases showing QDPR

Other Databases showing QDPR

Specialized Databases showing QDPR

Licensable Technologies
for QDPR

Services
for QDPR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

QDPR Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor QDPR

Summariesfor QDPR

Genomic Locationfor QDPR

Proteinsfor QDPR

Protein Domains/Familiesfor QDPR

Gene Functionfor QDPR

Pathways & Interactionsfor QDPR

Drugs & Compoundsfor QDPR

Transcriptsfor QDPR

Expression for QDPR

Orthologsfor QDPR

Paralogsfor QDPR

SNPs/Variantsfor QDPR

Disorders & Mutationsfor QDPR

Medical Newsfor QDPR

Publicationsfor QDPR

Search for QDPR

Genome Databases showing QDPR

Other Databases showing QDPR

Specialized Databases showing QDPR

Licensable Technologiesfor QDPR

Servicesfor QDPR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for QDPR

Summaries
for QDPR

Genomic Location
for QDPR

Proteins
for QDPR

Protein Domains/
Families
for QDPR

Gene Function
for QDPR

Pathways & Interactions
for QDPR

Drugs & Compounds
for QDPR

Transcripts
for QDPR

Expression
for QDPR

Orthologs
for QDPR

Paralogs
for QDPR

SNPs/Variants
for QDPR

Disorders & Mutations
for QDPR

Medical News
for QDPR

Publications
for QDPR

Licensable Technologies
for QDPR

Services
for QDPR