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Aliases & Descriptions for QARS
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.1.1.18 3 | | GLNRS 2, 5 | | GlnRS 3 | | PRO2195 2 |
| | | Descriptions |
|---|
| Glutamine--tRNA ligase 3 | | glutamine tRNA ligase 2 | | glutamine-tRNA synthetase 2 | | glutaminyl-tRNA synthetase 2 |
|
| | Search outside databases for aliases for QARS genePrevious GC identifers: GC03P046968 GC03P048503 GC03M048987 GC03M049092 |
Summaries for QARS(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for QARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq] Gene Wiki entry for QARS |
Genomic Location for QARS
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the QARS gene 
Entrez Gene cytogenetic band: 3p21.3-p21.1 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31QARS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M049108:
(about GC identifiers)
Start:
|
49,108,369 bp from pter |
End:
|
49,117,194 bp from pter |
Size:
|
8,826 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022517.17
| Proteins for QARS
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYQ_HUMAN, P47897 (See
protein sequence)Recommended Name: Glutaminyl-tRNA synthetase Size: 775 amino acids; 87799 Da
Subunit: Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro
Subcellular location: CytoplasmPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005042.1
ENSEMBL proteins: ENSP00000307567
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for QARS: Assays for QARS: | Protein
Domains/ Families for QARS(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P47897
ProtoNet protein and cluster: P47897 2 Blocks protein families: IPB000924 Glutamyl-tRNA synthetase signature IPB007639 Glutaminyl-tRNA synthetase
UniProtKB/Swiss-Prot: SYQ_HUMAN, P47897Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family | Gene Function for QARS
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005051
Applied Biosystems Silencer® siRNAs for QARS
Sigma-Aldrich siRNA for QARS  Sigma-Aldrich shRNA for QARS  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005051                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005051                                  untagged cDNA clone in CMV expression vector: NM_005051 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005051
UniProtKB/Swiss-Prot: SYQ_HUMAN, P47897Catalytic activity: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)Enzyme Number (IUBMB): EC 6.1.1.18 Genatlas biochemistry entry for QARS:glutamine-tRNA synthetase5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for QARS
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for QARS (Your Favorite Gene powered by Ingenuity) 
5/39 Interacting proteins for QARS (ENSP000003075673 P478971, 2) via UniProtKB, MINT, and/or STRING (see all 39
)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ENSG00000206318 | P486341, 2 | EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634 | | ENSG00000206427 | P486341, 2 | EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634 | | BAT2 | P486341, 2 | EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634 EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634 | | BAT2 | P486341, 2 | EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634 EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634 | | DUSP11 | O753192 | MINT-63202 | About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006424 | glutamyl-tRNA aminoacylation |
IEA | -- | | GO:0006425 | glutaminyl-tRNA aminoacylation |
IEA | -- | About this table
|
Drugs & Compounds for QARS(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for QARS 6 Novoseek chemical compound relationships for QARS gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| trna(gln) |
96.04 |
11 |
10860750 (2), 9372179 (2), 8078941 (1), 14729703 (1) (see all 5) |
| aminoacyl-trna |
86.98 |
1 |
8643392 (1) |
| trna |
84.81 |
43 |
8643392 (2), 9698378 (2), 10486006 (2), 9562563 (2) (see all 12) |
| acrylodan |
81.09 |
1 |
15966719 (1) |
| anticodon |
66.78 |
2 |
8199240 (1), 9372179 (1) |
| atp |
36.85 |
7 |
7659511 (1), 17444518 (1), 12737824 (1), 9372179 (1) (see all 5) |
About this table
|
Transcripts for QARS(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005051
Sigma-Aldrich siRNA for QARS  Sigma-Aldrich shRNA for QARS  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005051 REFSEQ mRNAs for QARS gene: NM_005051.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005051               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005051                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005051                                  untagged cDNA clone in CMV expression vector: NM_005051  Additional cDNA sequence: AF130067.1 AK056815.1 AK222510.1 AK290523.1 AK293260.1 AK297987.1 AK300220.1 AK301559.1 AK302867.1 BC000394.2 BC001567.1 BC001772.1 BC016634.1 BC029739.1 X76013.1 24/55 DOTS entries (see all 55
): DT.452919 DT.95100991 DT.100885556 DT.100885542 DT.100885572 DT.120923462 DT.95328884 DT.95313709 DT.100832404 DT.120923461 DT.100885565 DT.120923527 DT.100885546 DT.120923446 DT.120923569 DT.120923574 DT.120923477 DT.120923596 DT.100650187 DT.95100993 DT.100885550 DT.120923544 DT.100885537 DT.100885559 24/1126 AceView cDNA sequences (see all 1126
):AW793586 CB215357 BC001567 CA419875 AI754074 BE302125 NM_005051 BQ689378 AA700774 BU160141 BQ016324 BU169853 AA489824 CB128957 BQ641609 BP352006 BM923782 BM512406 BM917501 BG324028 AU120123 BE385743 BQ651294 BU168357
highest scoring ESTs for QARS:AA349845 AK056815 AL514586 AL520664 AL527062 AL527260 AL532202 AL535163 AL551019 AL551383 Unigene Cluster for QARS: Glutaminyl-tRNA synthetase Hs.79322 [show with all ESTs]Unigene Representative Sequence: AK222510
GeneLoc Exon Structure
5/25 Alternative Splicing Database (ASD) splice patterns (SP) for QARS (see all 25
)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | · | 3g | · | 3h | · | 3i | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   |
| ExUns: | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | |
| SP1: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 27a | · | 27b | ^ | 28a | · | 28b | ^ | 29 | |
| SP1: | - |   | |   | |   | |   | |   | |
| SP2: | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for QARS
1 Ensembl transcript including schematic representation: ENST00000306125
|
Expression for QARS
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| QARS expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for QARS
1 / 2 / 3 2 probe-sets matching QARS gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCAATAAAGA
SOURCE GeneReport for Unigene cluster: Hs.79322
|
Orthologs for QARS
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for QARS gene from 5/23 species (see all 23
)
About this table Species with no ortholog for QARS
ENSEMBL Gene Tree for QARS | Paralogs for QARS(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for QARS gene
- EPRS2
|
SNPs/Variants for QARS(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for QARS (up to first 250kb)
|
Disorders & Mutations for QARS
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603727
|
Medical News for QARS(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for QARS (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/39 PubMed articles for QARS gene (see all 39
):- Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer. (PubMed id 8078941)1, 2, 3, 4 Lamour V....Mirande M. (1994)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)3, 4 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS). (PubMed id 10393422)2, 3 Durkin M.E....Wewer U.M. (1999)
- Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. (PubMed id 9878398)1, 3 Quevillon S....Mirande M. (1999)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)4 Rikova K....Comb M.J. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)3 Stelzl U....Wanker E.E. (2005)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
- Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. (PubMed id 14667819)3 Lehner B....Sanderson C.M. (2004)
|
Search for QARS
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing QARS
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing QARS
(According to HUGE)
About This Section
| -- |
Specialized Databases showing QARS(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for QARS(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for QARS:

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| | Recombinant Proteins (QARS) | | Antibodies (QARS) |
| | | Search Tocris compounds for QARS |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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