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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

QARS Gene

protein-coding   GIFtS: 63
GCID: GC03M049108

Glutaminyl-TRNA Synthetase

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutaminyl-TRNA Synthetase1 2 3     Glutamine--TRNA Ligase2
EC 6.1.1.183 8     Glutamine-TRNA Synthetase2
GLNRS2 5     GlnRS3
Glutamine TRNA Ligase1     EC 6.1.18
PRO21952     

External Ids:    HGNC: 97511   Entrez Gene: 58592   Ensembl: ENSG000001720537   OMIM: 6037275   UniProtKB: P478973   

Export aliases for QARS gene to outside databases

Previous GC identifers: GC03P046968 GC03P048503 GC03M048987 GC03M049092


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for QARS Gene:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their
central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are
thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases
specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme
complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes,
mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated
Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for QARS Gene: 
QARS (glutaminyl-tRNA synthetase) is a protein-coding gene. Diseases associated with QARS include appendicitis, and among its related super-pathways are Cytosolic tRNA aminoacylation and Generic Transcription Pathway. GO annotations related to this gene include glutamine-tRNA ligase activity and ATP binding.

Gene Wiki entry for QARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the QARS gene promoter:
         ATF-2   MyoD   Olf-1   LUN-1   NF-E2 p45   PPAR-alpha   Max   CRE-BP1   NF-E2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQARS promoter sequence
   Search SABiosciences Chromatin IP Primers for QARS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat QARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

QARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QARS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049108:  view genomic region     (about GC identifiers)

Start:
49,133,365 bp from pter      End:
49,142,553 bp from pter
Size:
9,189 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYQ_HUMAN, P47897 (See protein sequence)
Recommended Name: Glutamine--tRNA ligase  
Size: 775 amino acids; 87799 Da
Subunit: Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and
Pro
Subcellular location: Cytoplasm

Explore the universe of human proteins at neXtProt for QARS: NX_P47897

Explore proteomics data for QARS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P47897

  • 4/8 DME Specific Peptides for QARS (P47897) (see all 8)
     ITHSLCT  TRFPPEP  RFDDTNP  APRAMAVL 

    QARS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    QARS Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001259002.1  NP_005042.1  

    ENSEMBL proteins: 
     ENSP00000396326   ENSP00000307567   ENSP00000389823   ENSP00000390015   ENSP00000392850  
     ENSP00000415247   ENSP00000414686   ENSP00000399119  
    Reactome Protein details: P47897
    Human Recombinant Protein Products for QARS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals QARS Proteins
    Novus Biologicals QARS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for QARS 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005759mitochondrial matrix TAS--
    GO:0005829cytosol TAS--

    QARS for ontologies           About GeneDecksing



    QARS Antibody Products: 
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    Cloud-Clone Corp. CLIAs for QARS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    aaRS1: Aminoacyl tRNA synthetases / Class I

    5/11 InterPro protein domains (see all 11):
     IPR007639 Gln-tRNA-synth_Ib_RNA-bd_N
     IPR020056 Rbsml_L25/Gln-tRNA_synth_b-brl
     IPR000924 Glu/Gln-tRNA-synth_Ib
     IPR004514 Gln-tRNA-synth_Ib
     IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd

    Graphical View of Domain Structure for InterPro Entry P47897

    ProtoNet protein and cluster: P47897

    2 Blocks protein domains:
    IPB000924 Glutamyl-tRNA synthetase signature
    IPB007639 Glutaminyl-tRNA synthetase


    UniProtKB/Swiss-Prot: SYQ_HUMAN, P47897
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    QARS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYQ_HUMAN, P47897
    Catalytic activity: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

         Genatlas biochemistry entry for QARS:
    glutamine-tRNA synthetase

         Enzyme Numbers (IUBMB): EC 6.1.1.181 2 EC 6.1.12

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004819glutamine-tRNA ligase activity TAS--
    GO:0005524ATP binding IEA--
    GO:0016876ligase activity, forming aminoacyl-tRNA and related compounds ----
         
    QARS for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for QARS:
     Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for QARS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for QARS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for QARS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for QARS 

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate QARS (see all 9):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7a
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QARS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for QARS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.54
    Cytosolic tRNA aminoacylation0.57
    Mitochondrial tRNA aminoacylation0.50
    2Generic Transcription Pathway
    Gene Expression0.47
    3Metabolism
    Metabolic pathways0.40
    4Glutamic acid signaling
    Glutamic acid signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for QARS
        Glutamic acid signaling


    4        Reactome Pathways for QARS
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression
    Mitochondrial tRNA aminoacylation


    2         Kegg Pathways  (Kegg details for QARS):
        Aminoacyl-tRNA biosynthesis
    Metabolic pathways


    QARS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for QARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/89 Interacting proteins for QARS (P478971, 2, 3 ENSP000003075674) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486341, 2, 3, ENSP000003874774EBI-347462,EBI-347545 MINT-62732 MINT-62808 MINT-62634 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486341, 2, 3, ENSP000004153634EBI-347462,EBI-347545 MINT-62732 MINT-62808 MINT-62634 I2D: score=5 STRING: ENSP00000415363
    PRRC2AP486341, 2, 3, ENSP000003651754EBI-347462,EBI-347545 MINT-62732 MINT-62808 MINT-62634 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486341, 2, 3EBI-347462,EBI-347545 MINT-62732 MINT-62808 MINT-62634 I2D: score=5 
    ENSG00000225164P486341, 2, 3EBI-347462,EBI-347545 MINT-62732 MINT-62808 MINT-62634 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation ----
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006425glutaminyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--
    GO:0043039tRNA aminoacylation ----

    QARS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    QARS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for QARS (SYQ)

    5 HMDB Compounds for QARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for QARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9enzymesubstrate16154153 16734422 17028132 17049867

    8 Novoseek inferred chemical compound relationships for QARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(gln) 96.4 11 10860750 (2), 9372179 (2), 8078941 (1), 14729703 (1) (see all 5)
    aminoacyl-trna 87.4 1 8643392 (1)
    trna 84.2 43 8643392 (2), 9698378 (2), 10486006 (2), 9562563 (2) (see all 12)
    acrylodan 80.4 1 15966719 (1)
    anticodon 65.9 2 8199240 (1), 9372179 (1)
    glutamine 60.1 5 9698378 (1), 8360919 (1), 12737824 (1), 9562563 (1)
    atp 35.4 7 7659511 (1), 17444518 (1), 12737824 (1), 9372179 (1) (see all 5)
    glutamate 32.1 6 15845537 (2), 9698378 (1), 17048947 (1)

    Search CenterWatch for drugs/clinical trials and news about QARS / SYQ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for QARS gene (2 alternative transcripts): 
    NM_001272073.1  NM_005051.2  

    Unigene Cluster for QARS:

    Glutaminyl-tRNA synthetase
    Hs.79322  [show with all ESTs]
    Unigene Representative Sequence: NM_005051
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000482248(uc011bcc.2) ENST00000453392 ENST00000306125(uc003cvx.3 uc003cvy.3 uc011bce.2)
    ENST00000475599 ENST00000487495 ENST00000497635 ENST00000430182 ENST00000494984
    ENST00000414533 ENST00000464962(uc011bcd.2) ENST00000459870 ENST00000470113
    ENST00000466179 ENST00000482468 ENST00000478561 ENST00000494838 ENST00000470225
    ENST00000494767
    miRNA
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    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7a
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    Additional mRNA sequence: 

    AF130067.1 AK056815.1 AK222510.1 AK290523.1 AK293260.1 AK297987.1 AK300220.1 AK301559.1 
    AK302867.1 BC000394.2 BC001567.1 BC001772.1 BC016634.1 BC029739.1 JN104585.1 NR_073590.1 
    X76013.1 

    24/55 DOTS entries (see all 55):

    DT.452919  DT.95100991  DT.100885556  DT.100885542  DT.100885572  DT.120923462  DT.95328884  DT.95313709 
    DT.100832404  DT.120923461  DT.100885565  DT.120923527  DT.100885546  DT.120923446  DT.120923569  DT.120923574 
    DT.120923477  DT.120923596  DT.100650187  DT.95100993  DT.100885550  DT.120923544  DT.100885537  DT.100885559 

    24/1126 AceView cDNA sequences (see all 1126):

    BU679749 BE280852 BM974711 BE540175 BP870474 BM833503 BP341218 AA877798 
    AU121373 BP344855 BU168357 AI754074 BG324028 BU169853 BG179717 BF037812 
    BQ651014 BI913969 BM834309 BM671657 BQ216199 BM842242 BQ420886 BM679365 

    GeneLoc Exon Structure

    5/25 Alternative Splicing Database (ASD) splice patterns (SP) for QARS (see all 25)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g · 3h · 3i ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a ·
    SP1:                                            -     -     -                       -     -     -     -                             -     -     -     -     -   
    SP2:                                            -     -     -                                         -                             -     -     -     -     -   
    SP3:                                                                                                  -                             -     -     -     -         
    SP4:                                            -     -     -                                         -                             -     -     -     -         
    SP5:                                                                                                  -                             -     -     -     -     -   

    ExUns: 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:              -     -     -                                                                                                                                 
    SP2:              -     -     -                                                                                                                                 
    SP3:              -     -     -                                                                                                                                 
    SP4:              -     -     -                                                                                                                                 
    SP5:              -     -     -                                                                                                                                 

    ExUns: 27a · 27b ^ 28a · 28b ^ 29
    SP1:  -                           
    SP2:  -                           
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for QARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    QARS expression in normal human tissues (normalized intensities)      QARS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATAAAGA
    QARS Expression
    About this image


    QARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Lung (Respiratory System)
             Trachea

    See QARS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for QARS

    SOURCE GeneReport for Unigene cluster: Hs.79322
        SABiosciences Custom PCR Arrays for QARS
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for QARS gene from 10/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Qars1 , 5 glutaminyl-tRNA synthetase1, 5 85.68(n)1
    89.94(a)1
      9 (59.44 cM)5
    975411  NM_133794.21  NP_598555.21 
     1085080055 
    chicken
    (Gallus gallus)
    Aves QARS1 glutaminyl-tRNA synthetase 74.86(n)
    78.54(a)
      416057  NM_001012782.1  NP_001012800.1 
    lizard
    (Anolis carolinensis)
    Reptilia QARS6
    Uncharacterized protein
    77(a)
    1 ↔ 1
    2(187979711-188014857)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691282 hypothetical protein MGC69128 75.34(n)    BC057752.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563952 similar to glutaminyl-tRNA synthetase 77.38(n)   394188  BC049420.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aats-gln1 , 3 glutaminyl-tRNA aminoacylation ATP
    binding3
    Glutaminyl-tRNA synthetase1
    57(a)3
    60.95(n)1
    58.31(a)1
      96C83
    457861  NM_080102.41  NP_524841.11 
    worm
    (Caenorhabditis elegans)
    Secernentea qrs-53
    qars-11
    tRNA synthetases class I (E and Q)3
    Protein QARS-11
    56(a)3
    57.23(n)1
    57.67(a)1
      IV(15008792-15013338)3
    1784151  NM_070411.51  NP_502812.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLN4(YOR168W)4
    GLN41
    Glutamine tRNA synthetase, monomeric class I tRNA synthetase more4
    Gln4p1
    47.28(n)1
    42.25(a)1
      15(649303-651732)4
    8543391, 4  NP_014811.31  NP_014811.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons OVA91 putative tRNA-glutamine synthetase 51.12(n)
    43.5(a)
      839120  NM_001198165.1  NP_001185094.1 
    rice
    (Oryza sativa)
    Liliopsida AK065125.12   -- 70.41(n)    AK065125.1 


    ENSEMBL Gene Tree for QARS (if available)
    TreeFam Gene Tree for QARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for QARS gene
    1 SIMAP similar gene for QARS using alignment to 11 protein entries:     SYQ_HUMAN (see all proteins):
    EPRS

    QARS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/309 SNPs in QARS are shown (see all 309)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1439862301,2
    C--49133552(+) CAGAAC/TAAGGC 3 -- int10--------
    rs1485454401,2
    --49133625(+) AAGCCA/GAGGGA 3 -- int10--------
    rs1428648791,2
    --49133676(+) TTTGGA/GTAAGG 3 -- int10--------
    rs1813723091,2
    --49133706(+) CTATAA/GTATTA 3 -- int10--------
    rs1856505961,2
    --49133743(+) GTCCAA/GGGTAT 3 -- int10--------
    rs1900172721,2
    --49133750(+) GTATAC/GTTTTA 3 -- int10--------
    rs1808784221,2
    --49133999(+) AGGCCA/GAGGCA 3 -- int10--------
    rs1871821471,2
    --49134325(+) AGGCAA/GGAGAA 3 -- int10--------
    rs1921131601,2
    --49134405(+) AGGGCA/GAGATA 3 -- int10--------
    rs343265531,2
    C,F--49134429(+) AGAAAA/GAAAAA 3 -- int12Minor allele frequency- G:0.08NA EA 240

    HapMap Linkage Disequilibrium report for QARS (49133365 - 49142553 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for QARS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834686CNV Loss17160897
    nsv876764CNV Loss21882294
    nsv876765CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603727    OMIM disorders: --

    2 diseases for QARS:    About MalaCards
    appendicitis    


    QARS for disorders           About GeneDecksing


    Export disorders for QARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for QARS gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with QARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer. (PubMed id 8078941)1, 2, 3, 9 Lamour V....Mirande M. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS). (PubMed id 10393422)1, 3 Durkin M.E....Wewer U.M. (1999)
    4. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. (PubMed id 9878398)1, 9 Quevillon S.... Mirande M. (1999)
    5. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    6. A Proteomics Strategy for the Identification of FAT10- Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5859 HGNC: 9751 AceView: QARS Ensembl:ENSG00000172053 euGenes: HUgn5859
    ECgene: QARS Kegg: 5859 H-InvDB: QARS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for QARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for QARS gene:
    Search GeneIP for patents involving QARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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