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QARS Gene

protein-coding   GIFtS: 64
GCID: GC03M049108

Glutaminyl-TRNA Synthetase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutaminyl-TRNA Synthetase1 2 3     Glutamine--TRNA Ligase2
EC 6.1.1.183 8     Glutamine-TRNA Synthetase2
GLNRS2 5     GlnRS3
Glutamine TRNA Ligase1     EC 6.1.18
PRO21952     

External Ids:    HGNC: 97511   Entrez Gene: 58592   Ensembl: ENSG000001720537   OMIM: 6037275   UniProtKB: P478973   

Export aliases for QARS gene to outside databases

Previous GC identifers: GC03P046968 GC03P048503 GC03M048987 GC03M049092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for QARS Gene:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their
central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are
thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases
specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme
complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes,
mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated
Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for QARS Gene:
QARS (glutaminyl-tRNA synthetase) is a protein-coding gene. Diseases associated with QARS include appendicitis, and malaria. GO annotations related to this gene include glutamine-tRNA ligase activity.

Gene Wiki entry for QARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the QARS gene promoter:
         ATF-2   MyoD   Olf-1   LUN-1   NF-E2 p45   PPAR-alpha   Max   CRE-BP1   NF-E2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidQARS promoter sequence
   Search Chromatin IP Primers for QARS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat QARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

QARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
QARS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049108:  view genomic region     (about GC identifiers)

Start:
49,133,365 bp from pter      End:
49,142,553 bp from pter
Size:
9,189 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SYQ_HUMAN, P47897 (See protein sequence)
Recommended Name: Glutamine--tRNA ligase  
Size: 775 amino acids; 87799 Da
Subunit: Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and
Pro

Explore the universe of human proteins at neXtProt for QARS: NX_P47897

Explore proteomics data for QARS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys394, Lys586, Lys601, Lys628
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for QARS (P47897) (see all 8)
     ITHSLCT  TRFPPEP  RFDDTNP  APRAMAVL 


    See QARS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001259002.1  NP_005042.1  

    ENSEMBL proteins: 
     ENSP00000396326   ENSP00000307567   ENSP00000389823   ENSP00000390015   ENSP00000392850  
     ENSP00000415247   ENSP00000414686   ENSP00000399119  
    Reactome Protein details: P47897

    QARS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for QARS
    OriGene Protein Over-expression Lysate for QARS
    OriGene MassSpec for QARS
    OriGene Custom Protein Services for QARS
    GenScript Custom Purified and Recombinant Proteins Services for QARS
    Novus Biologicals QARS Proteins
    Novus Biologicals QARS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for QARS

    QARS Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for QARS
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    ThermoFisher Antibody for QARS
    LSBio Antibodies in human, mouse, rat for QARS

    QARS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for QARS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for QARS
    Cloud-Clone Corp. CLIAs for QARS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS1: Aminoacyl tRNA synthetases / Class I

    Selected InterPro protein domains (see all 11):
     IPR007639 Gln-tRNA-synth_Ib_RNA-bd_N
     IPR020056 Rbsml_L25/Gln-tRNA_synth_b-brl
     IPR000924 Glu/Gln-tRNA-synth
     IPR004514 Gln-tRNA-synth
     IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd

    Graphical View of Domain Structure for InterPro Entry P47897

    ProtoNet protein and cluster: P47897

    2 Blocks protein domains:
    IPB000924 Glutamyl-tRNA synthetase signature
    IPB007639 Glutaminyl-tRNA synthetase


    UniProtKB/Swiss-Prot: SYQ_HUMAN, P47897
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    QARS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYQ_HUMAN, P47897
    Catalytic activity: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

         Genatlas biochemistry entry for QARS:
    glutamine-tRNA synthetase

         Enzyme Numbers (IUBMB): EC 6.1.1.181 2 EC 6.1.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004819glutamine-tRNA ligase activity TAS--
    GO:0005524ATP binding IEA--
    GO:0016876ligase activity, forming aminoacyl-tRNA and related compounds ----
         
    QARS for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for QARS:
     Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for QARS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for QARS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for QARS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for QARS

    miRNA
    Products:
        
    miRTarBase miRNAs that target QARS:
    hsa-mir-15b-5p (MIRT046503), hsa-let-7b-5p (MIRT032373), hsa-mir-9-5p (MIRT045782), hsa-mir-744-5p (MIRT037517), hsa-mir-17-5p (MIRT050906), hsa-mir-26b-5p (MIRT029505)

    Block miRNA regulation of human, mouse, rat QARS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate QARS (see all 9):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for QARS
    Predesigned siRNA for gene silencing in human, mouse, rat QARS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for QARS

    Clone
    Products:
         
    OriGene clones in human, mouse for QARS (see all 6)
    OriGene ORF clones in mouse, rat for QARS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: QARS (NM_005051)
    Sino Biological Human cDNA Clone for QARS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for QARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QARS

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for QARS
    Browse ESI BIO Cell Lines and PureStem Progenitors for QARS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for QARS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYQ_HUMAN, P47897: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005759mitochondrial matrix TAS--
    GO:0005829cytosol TAS--

    QARS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for QARS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.52
    Cytosolic tRNA aminoacylation0.57
    Mitochondrial tRNA aminoacylation0.50
    2Gene Expression
    Gene Expression0.40
    3Metabolism
    Metabolic pathways0.38
    4Glutamic acid signaling
    Glutamic acid signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for QARS
        Cytosolic tRNA aminoacylation
    Mitochondrial tRNA aminoacylation


    2 Kegg Pathways  (Kegg details for QARS):
        Aminoacyl-tRNA biosynthesis
    Metabolic pathways


    QARS for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for QARS
    Interactions:

        Search GeneGlobe Interaction Network for QARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for QARS (P478971, 2, 3 ENSP000003075674) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486341, 2, 3, ENSP000003874774EBI-347462,EBI-347545 MINT-62732 MINT-62808 MINT-62634 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486341, 2, 3, ENSP000004153634EBI-347462,EBI-347545 MINT-62732 MINT-62808 MINT-62634 I2D: score=5 STRING: ENSP00000415363
    PRRC2AP486341, 2, 3, ENSP000003651754EBI-347462,EBI-347545 MINT-62732 MINT-62808 MINT-62634 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486341, 2, 3EBI-347462,EBI-347545 MINT-62732 MINT-62808 MINT-62634 I2D: score=5 
    ENSG00000225164P486341, 2, 3EBI-347462,EBI-347545 MINT-62732 MINT-62808 MINT-62634 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation ----
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006425glutaminyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--
    GO:0043039tRNA aminoacylation ----

    QARS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for QARS (SYQ)

    5 HMDB Compounds for QARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for QARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9enzymesubstrate16154153 16734422 17028132 17049867

    8 Novoseek inferred chemical compound relationships for QARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(gln) 96.4 11 10860750 (2), 9372179 (2), 8078941 (1), 14729703 (1) (see all 5)
    aminoacyl-trna 87.4 1 8643392 (1)
    trna 84.2 43 8643392 (2), 9698378 (2), 10486006 (2), 9562563 (2) (see all 12)
    acrylodan 80.4 1 15966719 (1)
    anticodon 65.9 2 8199240 (1), 9372179 (1)
    glutamine 60.1 5 9698378 (1), 8360919 (1), 12737824 (1), 9562563 (1)
    atp 35.4 7 7659511 (1), 17444518 (1), 12737824 (1), 9372179 (1) (see all 5)
    glutamate 32.1 6 15845537 (2), 9698378 (1), 17048947 (1)



    QARS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for QARS gene (2 alternative transcripts): 
    NM_001272073.1  NM_005051.2  

    Unigene Cluster for QARS:

    Glutaminyl-tRNA synthetase
    Hs.79322  [show with all ESTs]
    Unigene Representative Sequence: NM_005051
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000482248(uc011bcc.2) ENST00000453392 ENST00000306125(uc003cvx.3 uc003cvy.3 uc011bce.2)
    ENST00000475599 ENST00000487495 ENST00000497635 ENST00000430182 ENST00000494984
    ENST00000414533 ENST00000464962(uc011bcd.2) ENST00000459870 ENST00000470113
    ENST00000466179 ENST00000482468 ENST00000478561 ENST00000494838 ENST00000470225
    ENST00000494767
    miRNA
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    Block miRNA regulation of human, mouse, rat QARS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate QARS (see all 9):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat QARS
    Clone
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    OriGene clones in human, mouse for QARS (see all 6)
    OriGene ORF clones in mouse, rat for QARS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: QARS (NM_005051)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for QARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat QARS
    Primer
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    OriGene qPCR primer pairs and template standards for QARS
    OriGene qSTAR qPCR primer pairs in human, mouse for QARS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat QARS
      QuantiTect SYBR Green Assays in human, mouse, rat QARS
      QuantiFast Probe-based Assays in human, mouse, rat QARS

    Additional mRNA sequence: 

    AF130067.1 AK056815.1 AK222510.1 AK290523.1 AK293260.1 AK297987.1 AK300220.1 AK301559.1 
    AK302867.1 BC000394.2 BC001567.1 BC001772.1 BC016634.1 BC029739.1 JN104585.1 NR_073590.1 
    X76013.1 

    Selected DOTS entries (see all 55):

    DT.452919  DT.95100991  DT.100885556  DT.100885542  DT.100885572  DT.120923462  DT.95328884  DT.95313709 
    DT.100832404  DT.120923461  DT.100885565  DT.120923527  DT.100885546  DT.120923446  DT.120923569  DT.120923574 
    DT.120923477  DT.120923596  DT.100650187  DT.95100993  DT.100885550  DT.120923544  DT.100885537  DT.100885559 

    Selected AceView cDNA sequences (see all 1126):

    AA584044 BQ575284 BU617142 BQ636289 BM705291 BQ048934 BM764111 AU121373 
    BM478568 AA368707 BM549030 BP870521 AI752521 BC016634 AW793586 BU168357 
    BU172753 BQ049531 BI756321 BM917501 BE302125 CD172460 BE255577 BM842242 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for QARS (see all 25)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g · 3h · 3i ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a ·
    SP1:                                            -     -     -                       -     -     -     -                             -     -     -     -     -   
    SP2:                                            -     -     -                                         -                             -     -     -     -     -   
    SP3:                                                                                                  -                             -     -     -     -         
    SP4:                                            -     -     -                                         -                             -     -     -     -         
    SP5:                                                                                                  -                             -     -     -     -     -   

    ExUns: 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:              -     -     -                                                                                                                                 
    SP2:              -     -     -                                                                                                                                 
    SP3:              -     -     -                                                                                                                                 
    SP4:              -     -     -                                                                                                                                 
    SP5:              -     -     -                                                                                                                                 

    ExUns: 27a · 27b ^ 28a · 28b ^ 29
    SP1:  -                           
    SP2:  -                           
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for QARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    QARS expression in normal human tissues (normalized intensities)      QARS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATAAAGA
    QARS Expression
    About this image


    QARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Lens
     
     Bone (Muscoskeletal System)
             Bone Marrow
    QARS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    QARS Protein Expression

    Genevestigator expression for QARS

    SOURCE GeneReport for Unigene cluster: Hs.79322
        Custom PCR Arrays for QARS
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for QARS gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Qars5 glutaminyl-tRNA synthetase   --   9 (59.44 cM) 108508005 
    chicken
    (Gallus gallus)
    Aves QARS1 glutaminyl-tRNA synthetase 74.86(n)
    78.54(a)
      416057  NM_001012782.1  NP_001012800.1 
    lizard
    (Anolis carolinensis)
    Reptilia QARS6
    glutaminyl-tRNA synthetase
    77(a)
    1 ↔ 1
    2(187979711-188014857)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691282 hypothetical protein MGC69128 75.34(n)    BC057752.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563952 similar to glutaminyl-tRNA synthetase 77.38(n)   394188  BC049420.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aats-gln1 , 3 glutaminyl-tRNA aminoacylation ATP
    binding3
    Glutaminyl-tRNA synthetase1
    57(a)3
    61.21(n)1
    58.31(a)1
      96C83
    457861  NM_080102.51  NP_524841.11 
    worm
    (Caenorhabditis elegans)
    Secernentea qrs-53
    qars-11
    tRNA synthetases class I (E and Q)3
    qars-11
    56(a)3
    57.19(n)1
    57.67(a)1
      IV(15008792-15013338)3
    1784151  NM_001268914.11  NP_001255843.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLN4(YOR168W)4
    GLN41
    Glutamine tRNA synthetase, monomeric class I tRNA synthetase more4
    GLN41
    47.52(n)1
    42.44(a)1
      15(649303-651732)4
    8543391, 4  NP_014811.31  NP_014811.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons OVA91 OVA9 51.47(n)
    44.42(a)
      839120  NM_102345.3  NP_173906.2 
    rice
    (Oryza sativa)
    Liliopsida AK065125.12   -- 70.41(n)    AK065125.1 


    ENSEMBL Gene Tree for QARS (if available)
    TreeFam Gene Tree for QARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for QARS gene
    1 SIMAP similar gene for QARS using alignment to 11 protein entries:     SYQ_HUMAN (see all proteins):
    EPRS

    QARS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for QARS (see all 309)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1439862301,2
    C--49133552(+) CAGAAC/TAAGGC 3 -- int10--------
    rs1485454401,2
    --49133625(+) AAGCCA/GAGGGA 3 -- int10--------
    rs1428648791,2
    --49133676(+) TTTGGA/GTAAGG 3 -- int10--------
    rs1813723091,2
    --49133706(+) CTATAA/GTATTA 3 -- int10--------
    rs1856505961,2
    --49133743(+) GTCCAA/GGGTAT 3 -- int10--------
    rs1900172721,2
    --49133750(+) GTATAC/GTTTTA 3 -- int10--------
    rs1808784221,2
    --49133999(+) AGGCCA/GAGGCA 3 -- int10--------
    rs1871821471,2
    --49134325(+) AGGCAA/GGAGAA 3 -- int10--------
    rs1921131601,2
    --49134405(+) AGGGCA/GAGATA 3 -- int10--------
    rs343265531,2
    C,F--49134429(+) AGAAAA/GAAAAA 3 -- int12Minor allele frequency- G:0.08NA EA 240

    HapMap Linkage Disequilibrium report for QARS (49133365 - 49142553 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for QARS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834686CNV Loss17160897
    nsv876764CNV Loss21882294
    nsv876765CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing QARS
    DNA2.0 Custom Variant and Variant Library Synthesis for QARS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603727    OMIM disorders: --

    3 diseases for QARS:    About MalaCards
    appendicitis    malaria    cerebritis


    QARS for disorders           About GeneDecksing


    Export disorders for QARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for QARS gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with QARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer. (PubMed id 8078941)1, 2, 3, 9 Lamour V....Mirande M. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)1, 2 Bienvenut W.V....Giglione C. (amp 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS). (PubMed id 10393422)1, 3 Durkin M.E....Wewer U.M. (Cytogenet. Cell Genet. 1999)
    5. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. (PubMed id 9878398)1, 9 Quevillon S.... Mirande M. (J. Mol. Biol. 1999)
    6. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases. (PubMed id 24003230)1 Wang F....Schimmel P. (J. Biol. Chem. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5859 HGNC: 9751 AceView: QARS Ensembl:ENSG00000172053 euGenes: HUgn5859
    ECgene: QARS Kegg: 5859 H-InvDB: QARS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for QARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for QARS gene:
    Search GeneIP for patents involving QARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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