Aliases for QARS Gene
External Ids for QARS Gene
Previous GeneCards Identifiers for QARS Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
GeneCards Summary for QARS Gene
QARS (Glutaminyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with QARS include diffuse cerebral and cerebellar atrophy-intractable seizures-progressive microcephaly syndrome and microcephaly, progressive, seizures, and cerebral and cerebellar atrophy. Among its related pathways are Metabolism and Gene Expression. GO annotations related to this gene include nucleotide binding and ligase activity, forming aminoacyl-tRNA and related compounds.
UniProtKB/Swiss-Prot for QARS Gene
Plays a critical role in brain development.