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QARS Gene

protein-coding   GIFtS: 62

GC03M049108
glutaminyl-tRNA synthetase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 6.1.1.18 3
GLNRS 2, 5
GlnRS 3
PRO2195 2
Descriptions
Glutamine--tRNA ligase 3
glutamine tRNA ligase 2
glutamine-tRNA synthetase 2
glutaminyl-tRNA synthetase 2
External Ids
HGNC: 97511
Entrez Gene: 58592
UniProtKB: P478973
Ensembl: ENSG000001720537
Search outside databases for aliases for QARS gene

Previous GC identifers: GC03P046968 GC03P048503 GC03M048987 GC03M049092

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for QARS:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because
of their central role in linking amino acids with nucleotide triplets contained in tRNAs,
aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution.
In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and
7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes,
glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts,
in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln).
Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by
RefSeq]

Gene Wiki entry for QARS
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the QARS gene  

Entrez Gene cytogenetic band: 3p21.3-p21.1   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

QARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049108:     (about GC identifiers)

Start:
49,108,369 bp from pter
End:
49,117,194 bp from pter
Size:
8,826 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.10  NT_022517.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SYQ_HUMAN, P47897 (See protein sequence)
Recommended Name: Glutaminyl-tRNA synthetase  
Size: 775 amino acids; 87799 Da
Subunit: Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu,
Lys, Met and Pro
Subcellular location: Cytoplasm

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005042.1  

    ENSEMBL proteins: 
    ENSP00000307567 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (QARS)
    Human Recombinant Proteins from Abnova (QARS)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for QARS: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for QARS
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (QARS), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (QARS)
    Novus Biologicals Antibodies for QARS

    Assays for QARS: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR007639 Gln-tRNA-synth_Ic_RNA-bd_1
     IPR000924 Glu/Gln-tRNA-synth_Ic
     IPR004514 Gln-tRNA-synth_Ic
     IPR001412 aa-tRNA-synth_I_CS
     IPR007638 Gln-tRNA-synth_Ic_RNA-bd_2


       GeneDecks  QARS for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P47897

    ProtoNet protein and cluster: P47897

    2 Blocks protein families:
    IPB000924 Glutamyl-tRNA synthetase signature
    IPB007639 Glutaminyl-tRNA synthetase


    UniProtKB/Swiss-Prot: SYQ_HUMAN, P47897
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (QARS)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (QARS)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005051

                  Applied Biosystems Silencer® siRNAs for QARS

                  Sigma-Aldrich siRNA for QARS  
                         Sigma-Aldrich shRNA for QARS  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for QARS
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005051
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005051
                                     untagged cDNA clone in CMV expression vector: NM_005051 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005051

    UniProtKB/Swiss-Prot: SYQ_HUMAN, P47897
    Catalytic activity: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)
    Enzyme Number (IUBMB): EC 6.1.1.18 

    Genatlas biochemistry entry for QARS:
    glutamine-tRNA synthetase

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004819 glutamine-tRNA ligase activity TAS8078941
    GO:0005515 protein binding IPI14667819
    GO:0005524 ATP binding IEA--
    GO:0016874 ligase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for QARS
     Glutamic acid signaling

       GeneDecks  QARS for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  QARS  (Your Favorite Gene powered by Ingenuity) 
     Glutamate Metabolism
     Aminoacyl-tRNA Biosynthesis

       GeneDecks  QARS for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for QARS):
     hsa00251 Glutamate metabolism
     hsa00970 Aminoacyl-tRNA biosynthesis

       GeneDecks  QARS for the pathways selected above  
    About GeneDecksing

    5/39 Interacting proteins for QARS (ENSP000003075673 P478971, 2) via UniProtKB, MINT, and/or STRING (see all 39 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206318P486341, 2EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634
    ENSG00000206427P486341, 2EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634
    BAT2P486341, 2EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634 EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634
    BAT2P486341, 2EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634 EBI-347462, EBI-347545 MINT-62732 MINT-62808 MINT-62634
    DUSP11O753192MINT-63202
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006424 glutamyl-tRNA aminoacylation IEA--
    GO:0006425 glutaminyl-tRNA aminoacylation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for QARS
    6 Novoseek chemical compound relationships for QARS gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(gln) 96.04 11 10860750 (2), 9372179 (2), 8078941 (1), 14729703 (1) (see all 5)
    aminoacyl-trna 86.98 1 8643392 (1)
    trna 84.81 43 8643392 (2), 9698378 (2), 10486006 (2), 9562563 (2) (see all 12)
    acrylodan 81.09 1 15966719 (1)
    anticodon 66.78 2 8199240 (1), 9372179 (1)
    atp 36.85 7 7659511 (1), 17444518 (1), 12737824 (1), 9372179 (1) (see all 5)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (QARS)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (QARS)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005051

                  Sigma-Aldrich siRNA for QARS  
                         Sigma-Aldrich shRNA for QARS  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005051  

    REFSEQ mRNAs for QARS gene: 

    NM_005051.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005051  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005051
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005051
                                     untagged cDNA clone in CMV expression vector: NM_005051 

    Additional cDNA sequence: 

    AF130067.1 AK056815.1 AK222510.1 AK290523.1 AK293260.1 AK297987.1 AK300220.1 AK301559.1 
    AK302867.1 BC000394.2 BC001567.1 BC001772.1 BC016634.1 BC029739.1 X76013.1 

    24/55 DOTS entries (see all 55 ):

    DT.452919  DT.95100991  DT.100885556  DT.100885542  DT.100885572  DT.120923462  DT.95328884  DT.95313709 
    DT.100832404  DT.120923461  DT.100885565  DT.120923527  DT.100885546  DT.120923446  DT.120923569  DT.120923574 
    DT.120923477  DT.120923596  DT.100650187  DT.95100993  DT.100885550  DT.120923544  DT.100885537  DT.100885559 

    24/1126 AceView cDNA sequences (see all 1126 ):

    AW793586 CB215357 BC001567 CA419875 AI754074 BE302125 NM_005051 BQ689378 
    AA700774 BU160141 BQ016324 BU169853 AA489824 CB128957 BQ641609 BP352006 
    BM923782 BM512406 BM917501 BG324028 AU120123 BE385743 BQ651294 BU168357 

    highest scoring ESTs for QARS:

    AA349845 AK056815 AL514586 AL520664 AL527062 AL527260 AL532202 AL535163 AL551019 AL551383 

    Unigene Cluster for QARS:

    Glutaminyl-tRNA synthetase
    Hs.79322  [show with all ESTs]
    Unigene Representative Sequence: AK222510


    GeneLoc Exon Structure

    5/25 Alternative Splicing Database (ASD) splice patterns (SP) for QARS (see all 25 )

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e · 3f · 3g · 3h · 3i ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a ·
    SP1:                                            -     -     -                       -     -     -     -                             -     -     -     -     -   
    SP2:                                            -     -     -                                         -                             -     -     -     -     -   
    SP3:                                                                                                  -                             -     -     -     -         
    SP4:                                            -     -     -                                         -                             -     -     -     -         
    SP5:                                                                                                  -                             -     -     -     -     -   

    ExUns: 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:              -     -     -                                                                                                                                 
    SP2:              -     -     -                                                                                                                                 
    SP3:              -     -     -                                                                                                                                 
    SP4:              -     -     -                                                                                                                                 
    SP5:              -     -     -                                                                                                                                 

    ExUns: 27a · 27b ^ 28a · 28b ^ 29
    SP1:  -                           
    SP2:  -                           
    SP3:                              
    SP4:                              
    SP5:                              

    About this scheme

    ECgene alternative splicing isoforms for QARS

    1 Ensembl transcript including schematic representation:
    ENST00000306125  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    QARS expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for QARS

    1 / 2 / 3

    2 probe-sets matching QARS gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    217846_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005051 0.60 1.00 0.82 1

    217846_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCAATAAAGA

    SOURCE GeneReport for Unigene cluster: Hs.79322
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for QARS gene from 5/23 species (see all 23 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    EPRS1   -- glutamyl-prolyl-tRNA synthetase 90.67(n)
    92.77(a)
    476628  XM_533833.2  XP_533833.2 
    chimpanzee
    (Pan troglodytes)
    EPRS1   -- glutamyl-prolyl-tRNA synthetase 99.57(n)
    99.61(a)
    743625  XM_001147632.1  XP_001147632.1 
    cow
    (Bos taurus)
    EPRS1   -- glutamyl-prolyl-tRNA synthetase 88.99(n)
    92.77(a)
    514586  NM_001034468.1  NP_001029640.1 
    rat
    (Rattus norvegicus)
    Qars1   -- glutaminyl-tRNA synthetase 86.71(n)
    92.77(a)
    290868  NM_001007624.1  NP_001007625.1 
    mouse
    (Mus musculus)
    Qars1, 5 95
    glutaminyl-tRNA synthetase1, 5 85.72(n)1
    90.06(a)1
    975411  NM_133794.11  NP_598555.11 
     AK0037945  AK0048145  (see all 27)
    About this table        Species with no ortholog for QARS

    ENSEMBL Gene Tree for QARS
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for QARS gene
    EPRS2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/26 NCBI SNPs in QARS are shown (see all 26 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 25)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs49554261,2
    C,F,H49118442(-) CAAATT/GTGGGG 1 -- ng317Minor allele frequency- G:0.09EU EA WA NA 544
    rs50307951,2
    C,F,H49116120(-) AGGCAC/TCGGCC 1 H/H syn1 ese35Minor allele frequency- T:0.07MN EU EA WA 602
    rs45134851,2
    A,C,F,H49114970(-) AGGATT/CAGTCA 1 -- int18Minor allele frequency- C:0.24EU EA WA NA 772
    rs45212681,2
    A,C,F,H49112908(-) TGTTTA/CATTTT 1 -- int14Minor allele frequency- C:0.26EU EA WA 400
    rs130647841,2
    F49110965(+) ACAACG/CAGGAC 1 -- int14Minor allele frequency- C:0.05NA EA 362
    rs115391481,2
    --49113814(-) CATCAA/GTTTCA 1 N/S mis10--------
    --
    rs50089491,2
    --49117068(-) TGCGCA/GAGGCC 1 E/K mis10--------
    rs626210671,2
    --49117146(+) GAAGAG/TCGACA 1 L/I mis10--------
    --
    rs76139751,2
    --49117948(+) aattaA/Gccggg 1 -- ng310--------
    rs626212221,2
    --49111360(+) GGGTGC/TAAAGG 1 A/T mis10--------
    About this table

    HapMap Linkage Disequilibrium images for QARS (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603727

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/39 PubMed articles for QARS gene (see all 39 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 5859 HGNC: 9751 AceView: QARS Ensembl:ENSG00000172053 euGenes: HUgn5859
    ECgene: QARS H-InvDB: QARS
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for QARS:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for QARS-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
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    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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