PIK3CD Gene
protein-coding GIFtS: 68
GCID: GC01P009711
|
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic...(Previous names: phosphoinositide-3-kinase, catalytic, delta polypeptide...)
| |
Aliases
for PIK3CD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Delta1 2 | | Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform2 | | P110D1 | | Phosphoinositide-3-Kinase C2 | | PtdIns-3-Kinase Subunit P110-Delta2 3 | | Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide Variant P37delta2 | | PI3Kdelta2 3 | | PI3-Kinase P110 Subunit Delta2 | | EC 2.7.1.1533 8 | | PI3K-Delta1 | | Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide1 | | P110delta1 | | P110DELTA2 | | Phosphatidylinositol 4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Delta3 | | PI3K2 | | PI3-Kinase Subunit Delta3 | | Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform2 | | PtdIns-3-Kinase Subunit Delta3 | | Phosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 KDa Catalytic Subunit Delta2 | | EC 2.7.18 |
Export aliases for PIK3CD gene to outside databasesPrevious GC identifers: GC01P009715 GC01P009555 GC01P009321 GC01P009421 GC01P009646 GC01P008867 |
Summaries
for PIK3CD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PIK3CD:
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The proteinencoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta,and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class IPI3Ks, this protein phosphorylates itself, not p85 protein.(provided by RefSeq, Jul 2010)
UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate)to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containingproteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival,proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation,migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response toanti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required forantibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cellchemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokineproduction of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signalingevents at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention toantigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion anddifferentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigendependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development andmigration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cellmaturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation.Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development andmast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion andmigration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is requiredfor its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERKphosphorylation and increased PI3K activity
 summary
for PIK3CD: PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.
Gene Wiki entry for PIK3CD (P110δ)
|
Genomic Views
for PIK3CD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PIK3CD gene promoter:
Pax-5 GATA-3 Pax-2 FOXO3 Pax-2a NF-kappaB FOXO3b NF-kappaB2 FOXO3a NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PIK3CD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIK3CD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.2 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.2PIK3CD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P009711: view genomic region
(about GC identifiers)
Start:
|
9,711,790 bp from pter |
End:
|
9,789,172 bp from pter |
Size:
|
77,383 bases |
Orientation:
|
plus strand |
|
Proteins
for PIK3CD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329 (See
protein sequence)Recommended Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Size: 1044 amino acids; 119479 Da
Subunit: Heterodimer of a catalytic subunit PIK3CD and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interactswith ERAS (By similarity). Interacts with HRAS
Subcellular location: Cytoplasm
Miscellaneous: IC87114 inhibitor reduces passive cutaneous anaphylaxis, attenuates allergic airway inflammation andhyperresponsiveness and allergen induced rhinitis response. Inhibitors may have therapeutic potential for thetreatment of immune system-mediated diseases such as auto-immune diseases, inflammation and allergy (PubMed:20940048;PubMed:17290298)
Secondary accessions: A6NCG0 G1FFP1 O15445 Q5SR49Alternative splicing: 2 isoforms: O00329-1 O00329-2 Explore the universe of human proteins at neXtProt for PIK3CD: NX_O00329
Post-translational modifications:
Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00329
4/15 DME Specific Peptides for PIK3CD (O00329) (see all 15)
PIK3CD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005017.3
ENSEMBL proteins: ENSP00000366563 ENSP00000354410 ENSP00000446444 ENSP00000443811 Reactome Protein details: O00329
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
PIK3CD for ontologies About GeneDecksing
PIK3CD Antibody Products:
Assay Products for PIK3CD: |
Protein
Domains /
Families
for PIK3CD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PIK3CD for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry O00329ProtoNet protein and cluster: O00329 3 Blocks protein families: IPB000341 Phosphoinositide 3-kinase IPB000403 Phosphatidylinositol 3- and 4-kinase IPB003113 Phosphatidylinositol 3-kinase
UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329Similarity: Belongs to the PI3/PI4-kinase familySimilarity: Contains 1 C2 PI3K-type domainSimilarity: Contains 1 PI3K-ABD domainSimilarity: Contains 1 PI3K-RBD domainSimilarity: Contains 1 PI3K/PI4K domainSimilarity: Contains 1 PIK helical domain |
Function
for PIK3CD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate)to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containingproteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival,proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation,migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response toanti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required forantibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cellchemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokineproduction of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signalingevents at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention toantigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion anddifferentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigendependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development andmigration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cellmaturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation.Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development andmast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion andmigration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is requiredfor its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERKphosphorylation and increased PI3K activityCatalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol3,4,5-trisphosphateEnzyme regulation: Activated by growth factors and cytokine receptors through a tyrosine-kinase-dependent mechanism.Activated by RAS. IC87114 inhibits lipid kinase activity and is selective in cells at doses up to 5-10 uM. IC87114blocks T-cell receptor signaling in naive and memory T-cells and reduces cytokine production by memory T-cells Genatlas biochemistry entry for PIK3CD:phosphatidylinositol 3-kinase,catalytic,class 1,delta,subunit,expressed in leukocytes,binding p85 adaptor proteins(PIK3R1,PIK3R2,PIK3R3) and associating with activated receptor protein-tyrosine kinases,regulating cellular responses
Enzyme Numbers (IUBMB): EC 2.7.1.1531 2 EC 2.7.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3CD (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3CD (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PIK3CD (NM_005026) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PIK3CD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CD |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIK3CD |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
PIK3CD for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PIK3CD:
Animal Models:
Mouse knock-outs for PIK3CD: Pik3cdtm1Tnr Pik3cdtm1Jni
9 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Pik3cd):
PIK3CD for phenotypes About GeneDecksing
|
Pathways & Interactions
for PIK3CD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/91 super-pathways (see all 91) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development HGF signaling pathway | | | 2 | Development_CNTF receptor signaling | | | 3 | IL-9 Signaling Pathways | | | 4 | Signaling by FGFR | | | 5 | PIP3 activates AKT signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/64 EMD Millipore Pathways for PIK3CD (see all 64)
5/9  R&D Systems Pathways for PIK3CD (see all 9)
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PIK3CD
5/9 Tocris Bioscience Pathways for PIK3CD (see all 9)
5/65  GeneGo (Thomson Reuters) Pathways for PIK3CD (see all 65)
5/15  BioSystems Pathways for PIK3CD (see all 15)
5/43 
Reactome Pathways for PIK3CD (see all 43)
3  PharmGKB Pathways for PIK3CD
5/44 
Kegg Pathways (Kegg details for PIK3CD) (see all 44):
UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329Pathway: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis
PIK3CD for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3CD
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/181 Interacting proteins for PIK3CD (O003291, 3 ENSP000003665634) via UniProtKB, MINT, STRING, and/or I2D (see all 181)
About this table
Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31): About this table
PIK3CD for ontologies About GeneDecksing
|
Drugs & Compounds
for PIK3CD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PIK3CD for compounds About GeneDecksing
Compounds for PIK3CD available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| LY 294002 hydrochloride | Selective PI 3-kinase inhibitor | [154447-36-6] | | Quercetin | Non-selective PI 3-kinase inhibitor | [117-39-5] | | PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | [371935-74-9] | | BAG 956 | Dual PI 3-kinase and PDK1 inhibitor | [853910-02-8] | | PI 828 | PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) | [942289-87-4] |
10/382 HMDB Compounds for PIK3CD (see all 382) About this table
1 DrugBank Compound for PIK3CD About this table
10/11 Novoseek chemical compound relationships for PIK3CD gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phosphoinositide |
88.2 |
26 |
12147247 (1), 12501193 (1), 15242973 (1), 19176369 (1) (see all 24) |
| phosphatidylinositol-3,4,5-trisphosphate |
78.3 |
3 |
9230105 (1), 17403925 (1), 18471983 (1) |
| phosphatidylinositol |
74.1 |
27 |
9235916 (3), 16341040 (1), 18377769 (1), 18332138 (1) (see all 21) |
| ly294002 |
55.8 |
6 |
18332138 (1), 12849077 (1), 16702948 (1), 10064595 (1) (see all 5) |
| tyrosine |
39.7 |
11 |
7691885 (2), 15242973 (1), 10064595 (1), 19075915 (1) (see all 9) |
| wortmannin |
38 |
5 |
19106158 (1), 10064595 (1), 11252727 (1) |
| lipid |
36.7 |
10 |
10064595 (2), 16516442 (2), 17178602 (1), 19931507 (1) (see all 7) |
| inositol |
35.6 |
1 |
16516442 (1) |
| threonine |
32.8 |
4 |
16341040 (1), 19745197 (1), 12244133 (1), 16516442 (1) |
| serine |
17.5 |
4 |
16341040 (1), 12244133 (1), 12502714 (1), 16516442 (1) |
Search CenterWatch for drugs/clinical trials and news about PIK3CD / PK3CD
|
Transcripts
for PIK3CD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PIK3CD gene: NM_005026.3 Unigene Cluster for PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta Hs.518451 [show with all ESTs]Unigene Representative Sequence: NM_0050267 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377346 ENST00000484851 ENST00000361110 ENST00000481137 ENST00000479223
ENST00000536656(uc001aqb.4 uc010oaf.2 uc021ogb.1 uc001aqe.4)
ENST00000543390
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3CD (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIK3CD (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PIK3CD (NM_005026) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PIK3CD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIK3CD |
Additional cDNA sequence: AB208835.1 AK303425.1 AK314191.1 BC030263.1 BC132919.1 BC132921.1 BC144264.1 BC150297.1 DQ263594.1 DQ263595.1 DQ263596.1 JN190435.1 U57843.1 U86453.1 Y10055.2 14 DOTS entries: DT.100816073 DT.121376768 DT.92454075 DT.102837436 DT.91751970 DT.95376344 DT.92454050 DT.97790994 DT.100816072 DT.121376620 DT.121376712 DT.91883164 DT.95283013 DT.303358 24/207 AceView cDNA sequences (see all 207): AA047473 BE327346 CB161298 AI371210 AL707253 AA281784 BQ436769 AW499827 BQ878471 AI962697 BE048397 AW205444 BQ883233 AW499604 BQ677923 BC030263 AW501532 CA307257 BQ641415 AW504513 AI969548 BQ050479 BQ683169 BQ679872
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PIK3CD (see all 11) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · |
|---|
|
| SP1: | | | | | - | | | | - | | - | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b |
|---|
|
| SP1: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PIK3CD
|
Expression
for PIK3CD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PIK3CD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTGTCTG
About this image
See PIK3CD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIK3CD
SOURCE GeneReport for Unigene cluster: Hs.518451
UniProtKB/Swiss-Prot: PK3CD_HUMAN, O00329Tissue specificity: Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low levels innormal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors and is abundantlyexpressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely expressed. Isoform 1 isexpressed predominantly in leukocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including PIK3CD:
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Orthologs
for PIK3CD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PIK3CD gene from 4/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PIK3CD1 |
phosphoinositide-3-kinase, catalytic, delta polypeptide |
76.89(n)
82.17(a) |
|
419444 NM_001012696.1 NP_001012714.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PIK3CD6 |
-- |
76(a) |
1 ↔ 1 |
LGh(43599-98773) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc634732 |
similar to phosphoinositide-3-kinase, catalytic, delta more |
75.82(n) |
|
394174 BC054896.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pi3K92E3 |
insulin receptor signaling pathway
phosphatidylinositol more |
39(a) |
|
92F3 -- |
ENSEMBL Gene Tree for PIK3CD (if available)
TreeFam Gene Tree for PIK3CD (if available) |
Paralogs
for PIK3CD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PIK3CD gene
- PIK3C2B2 PIK3CA2 PIK3C2G2 PIK3CG2 PIK3C32 PIK3CB2 PIK3C2A2
7 SIMAP similar genes for PIK3CD using alignment to 5 protein entries: PK3CD_HUMAN (see all proteins):DKFZp779K1237 PIK3CB DKFZp686G16234 PIK3CA PIK3CA variant protein PIK3C2A
PIK3CG
PIK3CD for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PIK3CD
PGOHUM00000239970
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Genomic Variants
for PIK3CD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PIK3CD (9711790 - 9789172 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PIK3CD
1 CNV: 5466
Human Gene Mutation Database (HGMD): PIK3CD
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIK3CD |
|
Disorders
/ Diseases
for PIK3CD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PIK3CD for disorders About GeneDecksing
OMIM gene information: 602839
OMIM disorders: --
20/52  diseases for PIK3CD (see all 52): About MalaCardsmast-cell leukemia toxic encephalopathy systemic mastocytosis mastocytosis
systemic lupus erythematosus acute promyelocytic leukemia myeloid leukemia lupus erythematosus
megakaryocytic leukemia chronic lymphocytic leukemia acute myeloid leukemia chronic myeloid leukemia
lymphocytic leukemia kaposi's sarcoma leukemia renal cell carcinoma
cblc chagas disease t-cell leukemia rheumatoid arthritis
8 Novoseek disease relationships for PIK3CD gene About this table
Human Genome Epidemiology (HuGE) Navigator: PIK3CD (9 documents)
Export disorders for PIK3CD gene to outside databases
|
Publications
for PIK3CD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PIK3CD gene, integrated from 9 sources (see all 176):
(articles sorted by number of sources associating them with PIK3CD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- P110delta, a novel phosphoinositide 3-kinase in leukocytes. (PubMed id 9113989)1, 2, 3, 9 Vanhaesebroeck B.A.M.... Waterfield M.D. (1997)
- Autophosphorylation of p110 delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. (PubMed id 10064595)1, 2, 9 Vanhaesebroeck B.... Waterfield M.D. (1999)
- PI3K p110delta regulates T-cell cytokine production d uring primary and secondary immune responses in mice and humans. (PubMed id 20081091)1, 2, 9 Soond D.R....Okkenhaug K. (2010)
- p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. (PubMed id 9235916)1, 2, 9 Chantry D.... Hoekstra M.F. (1997)
- p37d is a new isoform of PI3K p110d that increases cel l proliferation and is overexpressed in tumors. (PubMed id 22020336)1, 2 Fransson S....Ejeskar K. (2012)
- PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? (PubMed id 17290298)1, 2 Rommel C....Ji H. (2007)
- Identification and chromosome assignment of a human gene encoding a novel phosphatidylinositol-3 kinase. (PubMed id 9455486)1, 3 Seki N....Nakagawara A. (1997)
- The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. (PubMed id 17581634)1, 9 Papakonstanti E.A....Vanhaesebroeck B. (2007)
- Regulation of p110delta PI 3-kinase gene expression. (PubMed id 19357769)1, 9 Kok K....Vanhaesebroeck B. (2009)
- Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells. (PubMed id 18281552)1, 9 Boller D....Arcaro A. (2008)
|
External Searches for PIK3CD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
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Genome Databases showing PIK3CD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing PIK3CD gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PIK3CD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for PIK3CD | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PIK3CD gene:
Search GeneIP for patents involving PIK3CD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PIK3CD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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 | |
 |
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