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Aliases for PZP Gene

Aliases for PZP Gene

  • Pregnancy-Zone Protein 2 3
  • C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 6 3 4
  • CPAMD6 3 4
  • Pregnancy Zone Protein 3

External Ids for PZP Gene

Previous GeneCards Identifiers for PZP Gene

  • GC12M009009
  • GC12M009449
  • GC12M009201
  • GC12M009192
  • GC12M009301

Summaries for PZP Gene

GeneCards Summary for PZP Gene

PZP (Pregnancy-Zone Protein) is a Protein Coding gene. Diseases associated with PZP include oophoritis. Among its related pathways are Cell adhesion_Plasmin signaling. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is CD109.

UniProtKB/Swiss-Prot for PZP Gene

  • Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase

Gene Wiki entry for PZP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PZP Gene

Genomics for PZP Gene

Regulatory Elements for PZP Gene

Transcription factor binding sites by QIAGEN in the PZP gene promoter:

Genomic Location for PZP Gene

Start:
9,148,840 bp from pter
End:
9,208,370 bp from pter
Size:
59,531 bases
Orientation:
Minus strand

Genomic View for PZP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PZP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PZP Gene

Proteins for PZP Gene

  • Protein details for PZP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20742-PZP_HUMAN
    Recommended name:
    Pregnancy zone protein
    Protein Accession:
    P20742
    Secondary Accessions:
    • A6ND27
    • Q15273
    • Q2NKL2
    • Q7M4N7

    Protein attributes for PZP Gene

    Size:
    1482 amino acids
    Molecular mass:
    163863 Da
    Quaternary structure:
    • Homotetramer, which consists of two pairs of disulfide-linked chains

    Alternative splice isoforms for PZP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PZP Gene

Proteomics data for PZP Gene at MOPED

Post-translational modifications for PZP Gene

  • Glycosylation at Asn54, Asn69, Asn246, Asn392, Asn406, Asn753, Asn875, Asn932, Asn997, and Asn1430
  • Modification sites at PhosphoSitePlus

Other Protein References for PZP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PZP Gene

Domains for PZP Gene

Suggested Antigen Peptide Sequences for PZP Gene

Graphical View of Domain Structure for InterPro Entry

P20742

UniProtKB/Swiss-Prot:

PZP_HUMAN :
  • P20742
Family:
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
genes like me logo Genes that share domains with PZP: view

No data available for Gene Families for PZP Gene

Function for PZP Gene

Molecular function for PZP Gene

GENATLAS Biochemistry: pregnancy zone protein (see A2MR@)
UniProtKB/Swiss-Prot Function: Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase

Gene Ontology (GO) - Molecular Function for PZP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 2476433
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PZP: view
genes like me logo Genes that share phenotypes with PZP: view

Animal Models for PZP Gene

MGI Knock Outs for PZP:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PZP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PZP Gene

Localization for PZP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PZP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PZP Gene COMPARTMENTS Subcellular localization image for PZP gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PZP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space --
GO:0070062 extracellular exosome IDA 21362503
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with PZP: view

Pathways for PZP Gene

genes like me logo Genes that share pathways with PZP: view

Pathways by source for PZP Gene

1 GeneGo (Thomson Reuters) pathway for PZP Gene

Interacting Proteins for PZP Gene

Gene Ontology (GO) - Biological Process for PZP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS 2692707
GO:0010951 negative regulation of endopeptidase activity TAS 2476433
genes like me logo Genes that share ontologies with PZP: view

Compounds for PZP Gene

(2) Novoseek inferred chemical compound relationships for PZP Gene

Compound -log(P) Hits PubMed IDs
methylamine 69.1 3
steroid 0 1
genes like me logo Genes that share compounds with PZP: view

Transcripts for PZP Gene

mRNA/cDNA for PZP Gene

Unigene Clusters for PZP Gene

Pregnancy-zone protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PZP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PZP
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PZP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for PZP Gene

GeneLoc Exon Structure for
PZP
ECgene alternative splicing isoforms for
PZP

Expression for PZP Gene

mRNA expression in normal human tissues for PZP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PZP Gene

This gene is overexpressed in Liver (33.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PZP Gene

SOURCE GeneReport for Unigene cluster for PZP Gene Hs.707491

mRNA Expression by UniProt/SwissProt for PZP Gene

P20742-PZP_HUMAN
Tissue specificity: Plasma. Prominent constituent of late-pregnancy sera
genes like me logo Genes that share expressions with PZP: view

In Situ Assay Products

Orthologs for PZP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PZP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PZP 35
  • 99.35 (n)
  • 98.72 (a)
PZP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 56 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 59 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mug2 36
  • 56 (a)
ManyToMany
Pzp 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 55 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC68875 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8331 35
Species with no ortholog for PZP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PZP Gene

ENSEMBL:
Gene Tree for PZP (if available)
TreeFam:
Gene Tree for PZP (if available)

Paralogs for PZP Gene

Paralogs for PZP Gene

Selected SIMAP similar genes for PZP Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PZP Gene

genes like me logo Genes that share paralogs with PZP: view

Variants for PZP Gene

Sequence variations from dbSNP and Humsavar for PZP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs16861 -- 9,206,648(+) TTCTC(C/T)TTTGT intron-variant
rs876386 -- 9,158,830(+) CATTT(C/T)TATGC intron-variant
rs876387 -- 9,158,867(+) GTTTT(C/T)TTGGT intron-variant
rs876388 -- 9,158,909(+) GGGCT(C/T)TATGA intron-variant
rs919209 -- 9,181,153(+) GAAAC(A/G)TCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PZP Gene

Variant ID Type Subtype PubMed ID
nsv527404 CNV Gain 19592680
nsv523958 CNV Loss 19592680
nsv469101 CNV Loss 19166990

Relevant External Links for PZP Gene

HapMap Linkage Disequilibrium report
PZP
Human Gene Mutation Database (HGMD)
PZP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PZP Gene

Disorders for PZP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PZP Gene including...

Search for PZP Gene in MalaCards »

(1) University of Copenhagen DISEASES for PZP Gene

(1) Novoseek inferred disease relationships for PZP Gene

Disease -log(P) Hits PubMed IDs
trophoblastic disease 64.6 1

Relevant External Links for PZP

Genetic Association Database (GAD)
PZP
Human Genome Epidemiology (HuGE) Navigator
PZP
genes like me logo Genes that share disorders with PZP: view

No data available for UniProtKB/Swiss-Prot for PZP Gene

Publications for PZP Gene

  1. A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin. (PMID: 1692292) Marynen P. … Cassiman J.-J. (FEBS Lett. 1990) 3 4 23
  2. Primary structure of pregnancy zone protein. Molecular cloning of a full-length PZP cDNA clone by the polymerase chain reaction. (PMID: 1989698) Devriendt K. … Marynen P. (Biochim. Biophys. Acta 1991) 3 4 23
  3. Binding of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interaction. (PMID: 7513640) Philip A. … O'Connor-McCourt M.D. (Eur. J. Biochem. 1994) 3 23
  4. Interaction of matrix metalloproteinases-2 and -9 with pregnancy zone protein and alpha2-macroglobulin. (PMID: 9344465) ArbelA!ez L.F. … Stigbrand T. (Arch. Biochem. Biophys. 1997) 3 23
  5. Preparation and characterization of a C-terminal fragment of pregnancy zone protein corresponding to the receptor-binding peptide from human alpha 2-macroglobulin. (PMID: 8620037) Jensen P.E. … Stigbrand T. (Biochim. Biophys. Acta 1996) 3 23

Products for PZP Gene

Sources for PZP Gene

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