Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PZP Gene

Aliases for PZP Gene

  • Pregnancy-Zone Protein 2 3 5
  • C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 6 3 4
  • CPAMD6 3 4
  • Pregnancy Zone Protein 3

External Ids for PZP Gene

Previous GeneCards Identifiers for PZP Gene

  • GC12M009009
  • GC12M009449
  • GC12M009201
  • GC12M009192
  • GC12M009301

Summaries for PZP Gene

GeneCards Summary for PZP Gene

PZP (Pregnancy-Zone Protein) is a Protein Coding gene. Among its related pathways are Cell adhesion_Plasmin signaling. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is CD109.

UniProtKB/Swiss-Prot for PZP Gene

  • Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Gene Wiki entry for PZP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PZP Gene

Genomics for PZP Gene

Regulatory Elements for PZP Gene

Enhancers for PZP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PZP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PZP gene promoter:

Genomic Location for PZP Gene

Chromosome:
12
Start:
9,142,819 bp from pter
End:
9,208,370 bp from pter
Size:
65,552 bases
Orientation:
Minus strand

Genomic View for PZP Gene

Genes around PZP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PZP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PZP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PZP Gene

Proteins for PZP Gene

  • Protein details for PZP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20742-PZP_HUMAN
    Recommended name:
    Pregnancy zone protein
    Protein Accession:
    P20742
    Secondary Accessions:
    • A6ND27
    • Q15273
    • Q2NKL2
    • Q7M4N7

    Protein attributes for PZP Gene

    Size:
    1482 amino acids
    Molecular mass:
    163863 Da
    Quaternary structure:
    • Homotetramer, which consists of two pairs of disulfide-linked chains.

    Alternative splice isoforms for PZP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PZP Gene

Proteomics data for PZP Gene at MOPED

Post-translational modifications for PZP Gene

  • Glycosylation at Asn 54, Asn 69, Asn 246, Asn 392, Asn 406, Asn 753, Asn 875, Asn 932, Asn 997, and Asn 1430
  • Modification sites at PhosphoSitePlus

Other Protein References for PZP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PZP Gene

Domains & Families for PZP Gene

Suggested Antigen Peptide Sequences for PZP Gene

Graphical View of Domain Structure for InterPro Entry

P20742

UniProtKB/Swiss-Prot:

PZP_HUMAN :
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Family:
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
genes like me logo Genes that share domains with PZP: view

Function for PZP Gene

Molecular function for PZP Gene

GENATLAS Biochemistry:
pregnancy zone protein (see A2MR@)
UniProtKB/Swiss-Prot Function:
Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
genes like me logo Genes that share phenotypes with PZP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PZP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PZP Gene

Localization for PZP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PZP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PZP Gene COMPARTMENTS Subcellular localization image for PZP gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PZP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,NAS 14718574
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with PZP: view

Pathways & Interactions for PZP Gene

genes like me logo Genes that share pathways with PZP: view

Pathways by source for PZP Gene

1 GeneGo (Thomson Reuters) pathway for PZP Gene

Interacting Proteins for PZP Gene

Gene Ontology (GO) - Biological Process for PZP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity TAS 2476433
genes like me logo Genes that share ontologies with PZP: view

No data available for SIGNOR curated interactions for PZP Gene

Drugs & Compounds for PZP Gene

(1) Drugs for PZP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PZP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PZP: view

Transcripts for PZP Gene

Unigene Clusters for PZP Gene

Pregnancy-zone protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PZP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for PZP Gene

GeneLoc Exon Structure for
PZP
ECgene alternative splicing isoforms for
PZP

Expression for PZP Gene

mRNA expression in normal human tissues for PZP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PZP Gene

This gene is overexpressed in Liver (x33.4).

Protein differential expression in normal tissues from HIPED for PZP Gene

This gene is overexpressed in Plasma (20.6), Serum (16.4), Amniocyte (13.9), and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PZP Gene



SOURCE GeneReport for Unigene cluster for PZP Gene Hs.707491

mRNA Expression by UniProt/SwissProt for PZP Gene

P20742-PZP_HUMAN
Tissue specificity: Plasma. Prominent constituent of late-pregnancy sera.
genes like me logo Genes that share expression patterns with PZP: view

Primer Products

No data available for Protein tissue co-expression partners for PZP Gene

Orthologs for PZP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PZP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PZP 35
  • 99.35 (n)
  • 98.72 (a)
PZP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 56 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 59 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mug2 36
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 55 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8331 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68875 35
Species with no ortholog for PZP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PZP Gene

ENSEMBL:
Gene Tree for PZP (if available)
TreeFam:
Gene Tree for PZP (if available)

Paralogs for PZP Gene

Paralogs for PZP Gene

(5) SIMAP similar genes for PZP Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PZP Gene

genes like me logo Genes that share paralogs with PZP: view

Variants for PZP Gene

Sequence variations from dbSNP and Humsavar for PZP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2277413 - 9,165,188(-) AGAGG(C/T)CTTCA nc-transcript-variant, reference, missense
rs3213832 - 9,168,905(+) AGACA(C/T)GGAAG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs10842971 - 9,150,700(+) CTGGG(A/T)TGTCT reference, missense
rs12230214 - 9,194,196(+) GAAGA(C/G)TTTAT nc-transcript-variant, reference, missense
VAR_036235 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for PZP Gene

Variant ID Type Subtype PubMed ID
nsv527404 CNV Gain 19592680
nsv523958 CNV Loss 19592680
nsv469101 CNV Loss 19166990

Variation tolerance for PZP Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.89; 97.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PZP Gene

Human Gene Mutation Database (HGMD)
PZP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PZP Gene

Disorders for PZP Gene

Relevant External Links for PZP

Genetic Association Database (GAD)
PZP
Human Genome Epidemiology (HuGE) Navigator
PZP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PZP

No disorders were found for PZP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PZP Gene

Publications for PZP Gene

  1. Primary structure of pregnancy zone protein. Molecular cloning of a full-length PZP cDNA clone by the polymerase chain reaction. (PMID: 1989698) Devriendt K. … Marynen P. (Biochim. Biophys. Acta 1991) 3 4 23 67
  2. Interaction of matrix metalloproteinases-2 and -9 with pregnancy zone protein and alpha2-macroglobulin. (PMID: 9344465) ArbelA!ez L.F. … Stigbrand T. (Arch. Biochem. Biophys. 1997) 3 23
  3. Preparation and characterization of a C-terminal fragment of pregnancy zone protein corresponding to the receptor-binding peptide from human alpha 2-macroglobulin. (PMID: 8620037) Jensen P.E. … Stigbrand T. (Biochim. Biophys. Acta 1996) 3 23
  4. Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein. (PMID: 8662763) Valnickova Z. … Enghild J.J. (J. Biol. Chem. 1996) 3 23
  5. Binding of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interaction. (PMID: 7513640) Philip A. … O'Connor-McCourt M.D. (Eur. J. Biochem. 1994) 3 23

Products for PZP Gene

Sources for PZP Gene

Content