Aliases for PZP Gene
External Ids for PZP Gene
Previous GeneCards Identifiers for PZP Gene
GeneCards Summary for PZP Gene
PZP (PZP, Alpha-2-Macroglobulin Like) is a Protein Coding gene. Among its related pathways are Cell adhesion_Plasmin signaling. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is A2M.
UniProtKB/Swiss-Prot for PZP Gene
Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.