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PZP Gene

protein-coding   GIFtS: 57
GCID: GC12M009301

Pregnancy-Zone Protein

  See PZP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pregnancy-Zone Protein1 2
CPAMD62 3
C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 62 3
Pregnancy Zone Protein2

External Ids:    HGNC: 97501   Entrez Gene: 58582   Ensembl: ENSG000001268387   OMIM: 1764205   UniProtKB: P207423   

Export aliases for PZP gene to outside databases

Previous GC identifers: GC12M009009 GC12M009449 GC12M009201 GC12M009192


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PZP Gene:
PZP (pregnancy-zone protein) is a protein-coding gene. Diseases associated with PZP include oophoritis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is A2M.

UniProtKB/Swiss-Prot: PZP_HUMAN, P20742
Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a
peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When
a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the
proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high
molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is
hydrolyzed and mediates the covalent binding of the protein to the proteinase

Gene Wiki entry for PZP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PZP gene promoter:
         Nkx2-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPZP promoter sequence
   Search Chromatin IP Primers for PZP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PZP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13-p12.2   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13-p12.2

PZP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PZP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M009301:  view genomic region     (about GC identifiers)

Start:
9,301,436 bp from pter      End:
9,360,966 bp from pter
Size:
59,531 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PZP_HUMAN, P20742 (See protein sequence)
Recommended Name: Pregnancy zone protein precursor  
Size: 1482 amino acids; 163863 Da
Subunit: Homotetramer, which consists of two pairs of disulfide-linked chains
Secondary accessions: A6ND27 Q15273 Q2NKL2 Q7M4N7
Alternative splicing: 2 isoforms:  P20742-1   P20742-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PZP: NX_P20742

Explore proteomics data for PZP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn54, Asn69, Asn246, Asn392, Asn406, Asn753, Asn875, Asn932, Asn997, Asn1430
  • Modification sites at PhosphoSitePlus

  • See PZP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002855.2  
    ENSEMBL proteins: 
     ENSP00000261336   ENSP00000440811   ENSP00000371427  

    PZP Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PZP

     
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    antibodies-online proteins for PZP (5 products) 

     
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    antibodies-online antibodies for PZP (26 products) 

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    antibodies-online kits for PZP (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR014756 Ig_E-set
     IPR001599 Macroglobln_a2
     IPR011626 A2M_comp
     IPR002890 A2M_N
     IPR009048 A-macroglobulin_rcpt-bd

    Graphical View of Domain Structure for InterPro Entry P20742

    ProtoNet protein and cluster: P20742

    3 Blocks protein domains:
    IPB001599 Alpha-2-macroglobulin
    IPB002890 Alpha-2-macroglobulin
    IPB009048 Alpha-macroglobulin


    UniProtKB/Swiss-Prot: PZP_HUMAN, P20742
    Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family


    Find genes that share domains with PZP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PZP_HUMAN, P20742
    Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a
    peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When
    a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the
    proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high
    molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is
    hydrolyzed and mediates the covalent binding of the protein to the proteinase

         Genatlas biochemistry entry for PZP:
    pregnancy zone protein (see A2MR@)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity TAS2476433
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
         
    Find genes that share ontologies with PZP           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pzp) (see all 17):
     behavior/neurological  cardiovascular system  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  normal  reproductive system  respiratory system 

    Find genes that share phenotypes with PZP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PZP: Pzptm1Vln Pzptm1Lex

       genOway: Develop your customized and physiologically relevant rodent model for PZP

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PZP_HUMAN, P20742: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space ----
    GO:0070062extracellular vesicular exosome IDA--
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with PZP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PZP About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Plasmin signaling
    Cell adhesion Plasmin signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for PZP
        Cell adhesion Plasmin signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PZP
    Interactions:

        GeneGlobe Interaction Network for PZP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for PZP (ENSP000002613364) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPB2ENSP000001813834STRING: ENSP00000181383
    KLK3ENSP000003141514STRING: ENSP00000314151
    MMP2ENSP000002190704STRING: ENSP00000219070
    MMP9ENSP000003614054STRING: ENSP00000361405
    TGFB1ENSP000002219304STRING: ENSP00000221930
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007565female pregnancy TAS2692707
    GO:0010951negative regulation of endopeptidase activity TAS2476433

    Find genes that share ontologies with PZP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PZP

    2 Novoseek inferred chemical compound relationships for PZP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylamine 69.1 3 8269956 (2), 1282886 (1)
    steroid 0 1 7506680 (1)



    Find genes that share compounds with PZP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PZP gene: 
    NM_002864.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261336(uc001qvl.3) ENST00000535230(uc009zgl.3) ENST00000539983(uc010sgo.1)
    ENST00000546197(uc009zgm.1) ENST00000540995 ENST00000543108 ENST00000546116
    ENST00000381997
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat PZP

    13 AceView cDNA sequences:

    BX281528 AW827216 AA905669 NM_002864 AW275509 BG700837 AW513109 CB241643 
    X54380 AW070613 T29836 AW951621 BF847204 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PZP    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
    SP1:              -                     
    SP2:                                    


    ECgene alternative splicing isoforms for PZP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PZP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGTTTG
    PZP Expression
    About this image


    PZP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PZP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PZP Protein Expression

    UniProtKB/Swiss-Prot: PZP_HUMAN, P20742
    Tissue specificity: Plasma. Prominent constituent of late-pregnancy sera

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PZP gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pzp5 pregnancy zone protein   --   6 (63.02 cM) 128483573 
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    58(a)
    55(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    AADN03009394.1(259-7975)
    1(75682822-75711590)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    50(a)
    49(a)
    many ↔ many
    many ↔ many
    2(196279916-196430803)
    2(196353826-196426421)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688752 hypothetical protein MGC68875 76.09(n)    BC059294.1 


    ENSEMBL Gene Tree for PZP (if available)
    TreeFam Gene Tree for PZP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PZP gene
    A2M2  C52  C32  C4B2  C4A2  A2ML12  CPAMD82  CD1092  
    5 SIMAP similar genes for PZP using alignment to 3 protein entries:     PZP_HUMAN (see all proteins):
    A2M    DKFZp686C0338    OVOS2    A2ML1    OVOS1

    Find genes that share paralogs with PZP           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PZP
    PGOHUM00000239326 PGOHUM00000258620 PGOHUM00000258660


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PZP (see all 1329)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362354
    A colorectal cancer sample4--see VAR_0362352 R H mis40--------
    rs357582771,2
    C--9194864(+) AAAAA-/A/AAAA
            
    TTAGC
    1 -- int11NA 2
    rs1449155131,2
    --9301022(+) TGTTTA/GTAGAT 1 -- int10--------
    rs756134841,2
    F--9301221(+) TACCAC/TGTTTA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1903253201,2
    --9301228(+) TTTATA/GTTATC 1 -- int10--------
    rs1812023851,2
    --9301243(+) ATCCCC/TTTATG 1 -- int10--------
    rs1867055491,2
    --9301287(+) ATTCAA/GTTTCT 1 -- int10--------
    rs1387581941,2
    C--9301300(+) ACCTGA/CAACCT 1 -- int10--------
    rs789238881,2
    C,F--9301411(+) TGTCTG/TATGAA 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1907436541,2
    C--9301422(+) TGAATA/GATGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PZP (9301436 - 9360966 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PZP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469101CNV Loss19166990
    nsv523958CNV Loss19592680
    nsv527404CNV Gain19592680

    Human Gene Mutation Database (HGMD): PZP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PZP
    DNA2.0 Custom Variant and Variant Library Synthesis for PZP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176420    OMIM disorders: --

    1 disease for PZP:    
    About MalaCards
    oophoritis

    1 disease from the University of Copenhagen DISEASES database for PZP:
    Oophoritis

    Find genes that share disorders with PZP           About GenesLikeMe

    1 Novoseek inferred disease relationship for PZP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trophoblastic disease 64.6 1 1700464 (1)

    Genetic Association Database (GAD): PZP
    Human Genome Epidemiology (HuGE) Navigator: PZP (3 documents)

    Export disorders for PZP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PZP gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with PZP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of pregnancy zone protein. Molecular cloning of a full-length PZP cDNA clone by the polymerase chain reaction. (PubMed id 1989698)1, 2, 9 Devriendt K.... Marynen P. (Biochim. Biophys. Acta 1991)
    2. A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin. (PubMed id 1692292)1, 2, 9 Marynen P.... Cassiman J.-J. (FEBS Lett. 1990)
    3. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005)1, 4 Chalasani N....Rotter J.I. (Gastroenterology 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. (PubMed id 19105203)1, 4 Edwards T.L....Ritchie M.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. The alpha-macroglobulin bait region. Sequence diversity and localization of cleavage sites for proteinases in five mammalian alpha-macroglobulins. (PubMed id 2476433)1, 2 Sottrup-Jensen L.... Fey G.H. (J. Biol. Chem. 1989)
    8. A cluster of alpha 2-macroglobulin-related genes (alpha 2 M) on human chromosome 12p: cloning of the pregnancy-zone protein gene and an alpha 2M pseudogene. (PubMed id 2478422)1, 2 Devriendt K.... Marynen P. (Gene 1989)
    9. Pregnancy zone protein, a proteinase-binding macroglobulin. Interactions with proteinases and methylamine. (PubMed id 2692707)1, 2 Christensen U.... Sottrup-Jensen L. (Biochemistry 1989)
    10. Characterization of human pregnancy zone protein. Comparison with human alpha 2-macroglobulin. (PubMed id 2415522)1, 2 Sand O.... Sottrup-Jensen L. (J. Biol. Chem. 1985)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5858 HGNC: 9750 AceView: PZP Ensembl:ENSG00000126838 euGenes: HUgn5858
    ECgene: PZP H-InvDB: PZP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PZP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PZP gene:
    Search GeneIP for patents involving PZP

    GeneCards and IP:
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