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Aliases for PYY Gene

Aliases for PYY Gene

  • Peptide YY 2 3
  • Peptide Tyrosine Tyrosine 3 4
  • Prepro-PYY 2 3
  • PYY-I 3 4
  • PYY1 3

External Ids for PYY Gene

Previous GeneCards Identifiers for PYY Gene

  • GC17M041772
  • GC17M044207
  • GC17M042040
  • GC17M042505
  • GC17M039385
  • GC17M037794

Summaries for PYY Gene

Entrez Gene Summary for PYY Gene

  • The protein encoded by this gene is proteolytically processed to release a peptide that inhibits pancreatic secretion and mobility in the gut. Rare variations in this gene could increase susceptibility to obesity. [provided by RefSeq, Jul 2010]

GeneCards Summary for PYY Gene

PYY (Peptide YY) is a Protein Coding gene. Diseases associated with PYY include obesity, pyy-related and urachal adenocarcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is NPY.

UniProtKB/Swiss-Prot for PYY Gene

  • This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility

Gene Wiki entry for PYY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYY Gene

Genomics for PYY Gene

Regulatory Elements for PYY Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PYY Gene

43,952,738 bp from pter
44,004,469 bp from pter
51,732 bases
Minus strand

Genomic View for PYY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PYY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYY Gene

Proteins for PYY Gene

  • Protein details for PYY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptide YY
    Protein Accession:
    Secondary Accessions:
    • Q5U5Q6
    • Q6FGH8

    Protein attributes for PYY Gene

    97 amino acids
    Molecular mass:
    11145 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PYY Gene

    Alternative splice isoforms for PYY Gene


neXtProt entry for PYY Gene

Proteomics data for PYY Gene at MOPED

Post-translational modifications for PYY Gene

  • The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).

Other Protein References for PYY Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Assay Products

  • Enzo Life Sciences assays for PYY
  • antibodies-online kits for PYY

No data available for DME Specific Peptides for PYY Gene

Domains for PYY Gene

Gene Families for PYY Gene


Protein Domains for PYY Gene

Suggested Antigen Peptide Sequences for PYY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P10082
  • Belongs to the NPY family.
genes like me logo Genes that share domains with PYY: view

Function for PYY Gene

Molecular function for PYY Gene

GENATLAS Biochemistry: peptide YY,gut hormone,inhibiting exocrine pancreatic secretion
UniProtKB/Swiss-Prot Function: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility

Gene Ontology (GO) - Molecular Function for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005179 hormone activity TAS 10698177
GO:0005184 neuropeptide hormone activity IBA --
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with PYY: view
genes like me logo Genes that share phenotypes with PYY: view

Animal Models for PYY Gene

MGI Knock Outs for PYY:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PYY

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PYY Gene

Localization for PYY Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYY Gene


Subcellular locations from

Jensen Localization Image for PYY Gene COMPARTMENTS Subcellular localization image for PYY gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
plasma membrane 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with PYY: view

Pathways for PYY Gene

genes like me logo Genes that share pathways with PYY: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PYY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 10488139
GO:0007010 cytoskeleton organization TAS 7493937
GO:0007186 G-protein coupled receptor signaling pathway TAS 7592911
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007267 cell-cell signaling TAS 7493937
genes like me logo Genes that share ontologies with PYY: view

Compounds for PYY Gene

(69) Novoseek inferred chemical compound relationships for PYY Gene

Compound -log(P) Hits PubMed IDs
oxyntomodulin 93.7 74
biie0246 83.3 2
bibp3226 80.9 9
[pro...34...]npy 79.7 3
sr 120819a 77.9 2
genes like me logo Genes that share compounds with PYY: view

Transcripts for PYY Gene

mRNA/cDNA for PYY Gene

(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PYY Gene

Peptide YY:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PYY

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYY Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b

Relevant External Links for PYY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PYY Gene

mRNA expression in normal human tissues for PYY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PYY Gene

This gene is overexpressed in Colon - Transverse (31.7), Small Intestine - Terminal Ileum (13.7), and Colon - Sigmoid (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PYY Gene

SOURCE GeneReport for Unigene cluster for PYY Gene Hs.169249

genes like me logo Genes that share expressions with PYY: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PYY Gene

Orthologs for PYY Gene

This gene was present in the common ancestor of chordates.

Orthologs for PYY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PYY 35
  • 96.91 (n)
  • 96.91 (a)
PYY 36
  • 93 (a)
(Bos Taurus)
Mammalia PYY 35
  • 80.76 (n)
  • 72.16 (a)
PYY 36
  • 70 (a)
(Canis familiaris)
Mammalia PYY 35
  • 84.54 (n)
  • 77.32 (a)
PYY 36
  • 74 (a)
(Mus musculus)
Mammalia Pyy 35
  • 77.32 (n)
  • 72.16 (a)
Pyy 16
Pyy 36
  • 70 (a)
(Monodelphis domestica)
Mammalia PYY 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia PYY 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Pyy 35
  • 80.07 (n)
  • 74.23 (a)
(Gallus gallus)
Aves PPY 36
  • 34 (a)
(Anolis carolinensis)
Reptilia PYY 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pyy 35
  • 53.33 (n)
  • 56.67 (a)
(Danio rerio)
Actinopterygii pyya 35
  • 58.42 (n)
  • 49.48 (a)
pyyb 36
  • 41 (a)
Species with no ortholog for PYY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYY Gene

Gene Tree for PYY (if available)
Gene Tree for PYY (if available)

Paralogs for PYY Gene

Paralogs for PYY Gene

Selected SIMAP similar genes for PYY Gene using alignment to 1 proteins: Pseudogenes for PYY Gene

genes like me logo Genes that share paralogs with PYY: view

Variants for PYY Gene

Sequence variations from dbSNP and Humsavar for PYY Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs149420 -- 43,958,007(-) TCCTA(A/G)AGCGA utr-variant-5-prime
rs149421 -- 43,959,014(-) CACTT(A/C)TAGAT intron-variant
rs151122 -- 43,958,000(+) TCAGG(C/T)TTCGC utr-variant-5-prime
rs162430 -- 43,953,041(-) CATCA(C/T)TTAAC intron-variant
rs162431 -- 43,952,807(-) GCCCC(A/C)GCCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PYY Gene

Variant ID Type Subtype PubMed ID
nsv833454 CNV Loss 17160897
nsv112219 CNV Insertion 16902084
esv2675215 CNV Deletion 23128226

Relevant External Links for PYY Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYY Gene

Disorders for PYY Gene

MalaCards: The human disease database

MalaCards: The human disease database. (15) Diseases for PYY Gene including...

Search for PYY Gene in MalaCards »

(1) OMIM Diseases for PYY Gene (600781)

(48) Novoseek inferred disease relationships for PYY Gene

Disease -log(P) Hits PubMed IDs
obesity 68.1 66
anorexia nervosa 56.9 14
bulimia nervosa 53.1 10
malabsorption 52.8 5
prader-willi syndrome 51.7 6

Relevant External Links for PYY

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PYY: view

No data available for UniProtKB/Swiss-Prot for PYY Gene

Publications for PYY Gene

  1. Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. (PMID: 15331560) Hung C.C. … Farooqi I.S. (Diabetes 2004) 3 23 48
  2. Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. (PMID: 15855352) Ma L. … Baier L.J. (Diabetes 2005) 3 23 48
  3. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A. … Froguel P. (Diabetologia 2007) 3 23 48
  4. Y2 receptor gene variants reduce the risk of hypertension in obese children and adolescents. (PMID: 18622237) Santoro N. … Perrone L. (J. Hypertens. 2008) 3 23 48
  5. Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males. (PMID: 18987287) Broom D.R. … Stensel D.J. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009) 3 23

Products for PYY Gene

Sources for PYY Gene

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