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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PYY Gene

protein-coding GIFtS: 62
GCID: GC17M042040

peptide YY

Explore 69 diseases affiliated with
PYY via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Peptide YY¹ ²
PYY1¹ ²
Peptide Tyrosine Tyrosine² ³
PYY-I² ³

External Ids:	HGNC: 9748¹	Entrez Gene: 5697²	Ensembl: ENSG00000131096⁷	OMIM: 600781⁵	UniProtKB: P10082³

Export aliases for PYY gene to outside databases

Previous GC identifers: GC17M041772 GC17M044207 GC17M042505 GC17M039385 GC17M037794

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PYY:

The protein encoded by this gene is proteolytically processed to release a peptide that inhibits pancreatic secretion

and mobility in the gut. Rare variations in this gene could increase susceptibility to obesity. (provided by RefSeq,

Jul 2010)

UniProtKB/Swiss-Prot: PYY_HUMAN, P10082

Function: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal

and colonic mobility

Gene Wiki entry for PYY (Peptide YY)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PYY gene promoter:
E2F-4 E2F-3a E2F Sp1 E2F-2 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PYY promoter sequence

Search SABiosciences Chromatin IP Primers for PYY

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PYY

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.1

PYY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PYY gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M042040: view genomic region (about GC identifiers)

Start:	42,030,106 bp from pter	End:	42,081,837 bp from pter
Size:	51,732 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PYY_HUMAN, P10082 (See protein sequence)

Recommended Name: Peptide YY precursor

Size: 97 amino acids; 11145 Da

Subcellular location: Secreted

3 PDB 3D structures from and Proteopedia for PYY:

2DEZ (3D)

2DF0 (3D)

2L60 (3D)

Secondary accessions: Q5U5Q6 Q6FGH8

Alternative splicing: 2 isoforms: P10082-1 P10082-2

Explore the universe of human proteins at neXtProt for PYY: NX_P10082

PYY Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004151.3

ENSEMBL proteins:

ENSP00000353198 ENSP00000467310

Reactome Protein details: P10082
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: PYY OriGene Protein Over-expression Lysate: PYY OriGene Custom Protein Services for PYY
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	Novus Biologicals PYY Protein Novus Biologicals PYY Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PYY

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--

PYY for ontologies About GeneDecksing

PYY Antibody Products:

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	Uscn Antibodies for PYY
	ThermoFisher Antibody for PYY

Assay Products for PYY:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PYY

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PYY for domains About GeneDecksing

2 InterPro domains/families:

IPR001955 Pancreatic_hormone-like

IPR020392 Pancreatic_hormone-like_CS

Graphical View of Domain Structure for InterPro Entry P10082

ProtoNet protein and cluster: P10082

1 Blocks protein family: IPB001955 Pancreatic hormone

UniProtKB/Swiss-Prot: PYY_HUMAN, P10082

Similarity: Belongs to the NPY family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PYY_HUMAN, P10082

Function: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal

and colonic mobility

Genatlas biochemistry entry for PYY:

peptide YY,gut hormone,inhibiting exocrine pancreatic secretion

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PYY
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PYY
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PYY (see all 7) OriGene shRNA RFP: PYY OriGene siRNA: PYY
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for PYY

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PYY
		Search LifeMap BioReagents cell lines for PYY

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PYY

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	TAS	10698177
GO:0005184	neuropeptide hormone activity	IEA	--

PYY for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for PYY: Pyy^tm1.1Batt Pyy^tm1Mws
     7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Pyy):

adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism	nervous system
normal	skeleton

PYY for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Sympathetic Nerve Pathway (Neuroeffector Junction)

Sympathetic Nerve Pathway (Neuroeffector Junction)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 Reactome Pathways for PYY (see all 7)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events

1 PharmGKB Pathway for PYY

Sympathetic Nerve Pathway (Neuroeffector Junction)

PYY for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PYY

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/146 Interacting proteins for PYY (P10082^{2, 3} ENSP00000353198⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 146)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487²^,³, ENSP00000353731⁴	MINT-8090877 I2D: score=1 STRING: ENSP00000353731
FAP	Q12884²^,³, ENSP00000188790⁴	MINT-8090673 I2D: score=1 STRING: ENSP00000188790
MEP1B	Q16820³, ENSP00000269202⁴	I2D: score=1 STRING: ENSP00000269202
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADORA1	ENSP00000308549⁴	STRING: ENSP00000308549

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cellular component movement	TAS	10488139
GO:0007010	cytoskeleton organization	TAS	7493937
GO:0007186	G-protein coupled receptor signaling pathway	TAS	7592911
GO:0007267	cell-cell signaling	TAS	7493937
GO:0007586	digestion	TAS	7493937

PYY for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PYY for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PYY
10/69 Novoseek chemical compound relationships for PYY gene (see all 69) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oxyntomodulin	93.7	111	8406158 (5), 8654152 (4), 17082808 (4), 12296450 (3) (see all 51)
biie0246	83.3	2	19119448 (1), 11408607 (1)
bibp3226	80.9	11	8880067 (3), 9421306 (2), 10658578 (1), 11906964 (1) (see all 6)
[pro...34...]npy	79.7	5	10737675 (2), 8961073 (1)
sr 120819a	77.9	2	10858507 (2)
bibo3304	67.9	1	11906964 (1)
enterogastrone	67	3	9198086 (1), 9200286 (1)
orlistat	53.6	9	18647814 (5)
incretin	50.6	2	19918005 (1), 20380653 (1)
pramlintide	48.1	1	16625817 (1)

Search CenterWatch for drugs/clinical trials and news about PYY

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PYY gene:

NM_004160.4

Unigene Cluster for PYY:

Peptide YY

Hs.169249 [show with all ESTs]

Unigene Representative Sequence: BM549164

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000360085(uc002ieq.3 uc002ier.1) ENST00000592796

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PYY
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PYY (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PYY (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PYY (NM_004160)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PYY Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PYY
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PYY

Additional cDNA sequence:

BC041057.1 CR542129.1 D13899.1 D13902.1

2 DOTS entries:

DT.452118 DT.87046273

12 AceView cDNA sequences:

T27211 T27212 AA913288 BC041057 NM_004160 D13902 CR542129 AW136574

D13899 BM549164 AI654355 AI183955

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for PYY About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b
SP1:
SP2:

ECgene alternative splicing isoforms for PYY

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PYY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCTGGAGG

About this image

PYY expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Medulla Oblongata

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PYY Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PYY

SOURCE GeneReport for Unigene cluster: Hs.169249

SABiosciences Expression via Pathway-Focused PCR Arrays including PYY:

Obesity in human mouse rat

PPAR Targets in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PYY

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PYY gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pyy^{1 , 5}	peptide YY^{1, 5}	76.98(n)¹ 72.16(a)¹		11 (65.48 cM)⁵ 217212¹ NM_145435.1¹ NP_663410.1¹ 102106676⁵
lizard (Anolis carolinensis)	Reptilia	PYY⁶	--	55(a)	1 ↔ 1	6(77846957-77849759)
zebrafish (Danio rerio)	Actinopterygii	pyya¹	peptide YYa	58.42(n) 49.48(a)		30211 NM_001164371.1 NP_001157843.1

ENSEMBL Gene Tree for PYY (if available)
TreeFam Gene Tree for PYY (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PYY gene

NPY²

4 SIMAP similar genes for PYY using alignment to 1 protein entry: PYY_HUMAN:

PYY2 PYY3 NPY PPY

PYY for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for PYY
PGOHUM00000259214 PGOHUM00000260961

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201732745^1,2	C	--	37793920(-)	`GCTGGA/GGGTGA`	1	--	ds500¹		0	--	--	--	--
rs457593^1,2	C,H	--	37793946(+)	`CGCTAG/TTACTA`	1	--	ds500¹		5		MN NS EA	602
rs464843^1,2	H	--	37794056(-)	`GCCTAG/TGAGAG`	1	--	ds500¹		5		MN NS EA	604
rs1662755^1,2	C,H	--	37794312(+)	`CACTTC/TTACGG`	1	--	ds500¹		5		MN NS EA	604
rs465407^1,2	H	--	37794600(-)	`GCCCAG/CACCTG`	2	/H /D	mis¹ ese³		7		MN NS EA NA	598
rs73986642^1,2	C,	--	37795246(+)	`CCACCG/AGGCTT`	1	--	int¹		2		WA	120
rs467148^1,2	H	--	37795270(-)	`GTGCAG/CTGCCC`	1	--	int¹		5		MN NS EA	588
rs73986643^1,2	C,	--	37795337(+)	`ACCCCC/AACCCC`	1	--	int¹		2		WA	120
rs186691^1,2	H	--	37795356(-)	`GGGAAG/AGAGGC`	1	--	int¹ trp³		6		MN NS EA NA	606
rs8067343^1,2	C,F,A,	--	37795465(+)	`GGCTTG/AAGCCC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for PYY (42030106 - 42081837 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PYY: --
Human Gene Mutation Database (HGMD): PYY

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PYY

DNA2.0 Custom Variant and Variant Library Synthesis for PYY

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PYY for disorders           About GeneDecksing

OMIM gene information: 600781
OMIM disorders: 601665
20/69 diseases for PYY (see all 69):    About MalaCards

prader-willi syndrome normal pressure hydrocephalus obesity gastroesophageal reflux disease

pancreatitis bulimia nervosa duodenogastric reflux dumping syndrome

short bowel syndrome dermoid cyst anorexia nervosa type 2 diabetes mellitus

eating disorder urachal adenocarcinoma inflammatory bowel disease autism spectrum disorder

irritable bowel syndrome polycystic ovary syndrome insulin resistance diabetes mellitus

7 diseases from the University of Copenhagen DISEASES database for PYY:

Constipation Diabetes mellitus Morbid obesity Prader-Willi syndrome

Diarrhea Short bowel syndrome Eating disorder

10/48 Novoseek disease relationships for PYY gene (see all 48) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
obesity	68.1	92	15855352 (3), 17235527 (3), 15331560 (3), 15657373 (2) (see all 47)
anorexia nervosa	56.9	21	18486583 (2), 17119001 (2), 17054989 (2), 15657373 (1) (see all 11)
bulimia nervosa	53.1	13	15638873 (2), 15820714 (2), 10418705 (2), 2350207 (1) (see all 7)
malabsorption	52.8	5	16756746 (2), 8489548 (1), 18609141 (1), 8345132 (1)
prader-willi syndrome	51.7	6	15754036 (2), 20019130 (2), 17223988 (1), 17596650 (1)
obesity morbid	46.2	2	15855352 (1), 17443025 (1)
short bowel syndrome	43.6	2	19176401 (2)
hypomotility	42.7	1	19864732 (1)
insulin sensitivity	39.8	12	20432813 (2), 16720664 (2), 18317469 (1), 17210210 (1) (see all 7)
carcinoid	38.8	14	7896203 (3), 10029457 (2), 12468356 (2), 17578375 (2) (see all 7)

Genetic Association Database (GAD): PYY
Human Genome Epidemiology (HuGE) Navigator: PYY (17 documents)

Export disorders for PYY gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PYY gene, integrated from 9 sources (see all 648):
(articles sorted by number of sources associating them with PYY)

Utopia: connect your pdf to the dynamic
world of online information

Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. (PubMed id 15331560)^{1, 4, 9} Hung C.C....Farooqi I.S. (2004)
Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1. (PubMed id 7782089)^{1, 3, 9} Hort Y....Herzog H. (1995)
Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. (PubMed id 15855352)^{1, 4, 9} Ma L....Baier L.J. (2005)
The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR. (PubMed id 16819834)^{1, 2} Nygaard R.... Poulsen F.M. (2006)
Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes. (PubMed id 15983231)^{1, 4} Torekov S.S....Pedersen O. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and structural determination of human peptide YY cDNA and gene. (PubMed id 8318545)^{1, 2} Kohri K.... Okamoto H. (1993)
A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36). (PubMed id 2587421)^{1, 2} Eberlein G.A....Reeve J.R. Jr. (1989)
Isolation and primary structure of human peptide YY. (PubMed id 3202875)^{1, 2} Tatemoto K....Go V.L.W. (1988)
Peptide YY (PYY) gene polymorphisms in the 3'-untrans lated and proximal promoter regions regulate cellular gene expression and PYY s ecretion and metabolic syndrome traits in vivo. (PubMed id 19820027)^{1, 9} Shih P.A....O'Connor D.T. (2009)

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Entrez Gene: 5697	HGNC: 9748	AceView: PYY	Ensembl:ENSG00000131096	euGenes: HUgn5697
ECgene: PYY	H-InvDB: PYY

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
PharmGKB entry for PYY	Pharmacogenomics, SNPs, Pathways

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Patent Information for PYY gene:
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