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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PYY Gene

protein-coding   GIFtS: 63
GCID: GC17M042040

Peptide YY

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptide YY1 2
prepro-PYY1 2
Peptide Tyrosine Tyrosine2 3
PYY-I2 3
PYY12

External Ids:    HGNC: 97481   Entrez Gene: 56972   Ensembl: ENSG000001310967   OMIM: 6007815   UniProtKB: P100823   

Export aliases for PYY gene to outside databases

Previous GC identifers: GC17M041772 GC17M044207 GC17M042505 GC17M039385 GC17M037794


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PYY Gene:
The protein encoded by this gene is proteolytically processed to release a peptide that inhibits pancreatic
secretion and mobility in the gut. Rare variations in this gene could increase susceptibility to obesity.
(provided by RefSeq, Jul 2010)

GeneCards Summary for PYY Gene: 
PYY (peptide YY) is a protein-coding gene. Diseases associated with PYY include short bowel syndrome, and urachal adenocarcinoma, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include neuropeptide hormone activity and hormone activity. An important paralog of this gene is NPY.

UniProtKB/Swiss-Prot: PYY_HUMAN, P10082
Function: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis
jejunal and colonic mobility

Gene Wiki entry for PYY (Peptide YY) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PYY gene promoter:
         E2F-4   E2F-3a   E2F   Sp1   E2F-2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPYY promoter sequence
   Search SABiosciences Chromatin IP Primers for PYY

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PYY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.1

PYY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PYY gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M042040:  view genomic region     (about GC identifiers)

Start:
42,030,106 bp from pter      End:
42,081,837 bp from pter
Size:
51,732 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PYY_HUMAN, P10082 (See protein sequence)
Recommended Name: Peptide YY precursor  
Size: 97 amino acids; 11145 Da
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for PYY:
2DEZ (3D)        2DF0 (3D)        2L60 (3D)    
Secondary accessions: Q5U5Q6 Q6FGH8
Alternative splicing: 2 isoforms:  P10082-1   P10082-2   

Explore the universe of human proteins at neXtProt for PYY: NX_P10082

Explore proteomics data for PYY at MOPED 

PYY Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

PYY Protein Expression

REFSEQ proteins: NP_004151.3  
ENSEMBL proteins: 
 ENSP00000353198   ENSP00000467310  
Reactome Protein details: P10082
Human Recombinant Protein Products for PYY: 
Browse Purified and Recombinant Proteins at EMD Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for PYY
OriGene Protein Over-expression Lysate for PYY
OriGene MassSpec for PYY 
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GenScript Custom Purified and Recombinant Proteins Services for PYY
Novus Biologicals PYY Protein
Novus Biologicals PYY Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for PYY 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

PYY for ontologies           About GeneDecksing



PYY Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of PYY
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Novus Biologicals PYY Antibodies
Abcam antibodies for PYY
Cloud-Clone Corp. Antibodies for PYY 
ThermoFisher Antibody for PYY
LSBio Antibodies in human, mouse, rat for PYY 

Assay Products for PYY: 
EMD Millipore Kits and Assays for the Analysis of PYY
OriGene Custom Assay Services for PYY
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for PYY
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for PYY 
Cloud-Clone Corp. CLIAs for PYY


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

2 InterPro protein domains:
 IPR001955 Pancreatic_hormone-like
 IPR020392 Pancreatic_hormone-like_CS

Graphical View of Domain Structure for InterPro Entry P10082

ProtoNet protein and cluster: P10082

1 Blocks protein domain: IPB001955 Pancreatic hormone

UniProtKB/Swiss-Prot: PYY_HUMAN, P10082
Similarity: Belongs to the NPY family


PYY for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PYY_HUMAN, P10082
Function: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis
jejunal and colonic mobility

     Genatlas biochemistry entry for PYY:
peptide YY,gut hormone,inhibiting exocrine pancreatic secretion

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity TAS10698177
GO:0005184neuropeptide hormone activity IEA--
GO:0005515protein binding IPI--
     
PYY for ontologies           About GeneDecksing


Phenotypes:
     7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Pyy):
 adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  nervous system 
 normal  skeleton 

PYY for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for PYY: Pyytm1.1Batt Pyytm1Mws

   inGenious Targeting Laboratory - Custom generated mouse model solutions for PYY 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PYY

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PYY 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PYY 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PYY
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PYY
SwitchGear 3'UTR luciferase reporter plasmidPYY 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for PYY
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PYY

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for PYY
Sirion Biotech Customized adenovirus for overexpression of PYY

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for PYY (see all 7)
OriGene ORF clones in mouse, rat for PYY
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PYY (NM_004160)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PYY
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PYY
Sirion Biotech Customized lentivirus for stable overexpression of PYY 
                     Customized lentivirus expression plasmids for stable overexpression of PYY 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for PYY
Search LifeMap BioReagents cell lines for PYY
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PYY


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for PYY About                                                                                                See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.46
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Adrenoceptors
Sympathetic Nerve Pathway (Neuroeffector Junction)0.33

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/7        Reactome Pathways for PYY (see all 7)
    GPCR downstream signaling
Peptide ligand-binding receptors
Signal Transduction
Signaling by GPCR
G alpha (i) signalling events

1 PharmGKB Pathway for PYY
    Sympathetic Nerve Pathway (Neuroeffector Junction)


PYY for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PYY

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/146 Interacting proteins for PYY (P100822, 3 ENSP000003531984) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
InteractantInteraction Details
GeneCardExternal ID(s)
DPP4P274872, 3, ENSP000003537314MINT-8090877 I2D: score=1 STRING: ENSP00000353731
FAPQ128842, 3, ENSP000001887904MINT-8090673 I2D: score=1 STRING: ENSP00000188790
MEP1BQ168203, ENSP000002692024I2D: score=1 STRING: ENSP00000269202
ADCY2ENSP000003429524STRING: ENSP00000342952
ADORA1ENSP000003085494STRING: ENSP00000308549
About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006928cellular component movement TAS10488139
GO:0007010cytoskeleton organization TAS7493937
GO:0007186G-protein coupled receptor signaling pathway TAS7592911
GO:0007267cell-cell signaling TAS7493937
GO:0007586digestion TAS7493937

PYY for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PYY for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PYY

10/69 Novoseek inferred chemical compound relationships for PYY gene (see all 69)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
oxyntomodulin 93.7 111 8406158 (5), 8654152 (4), 17082808 (4), 12296450 (3) (see all 51)
biie0246 83.3 2 19119448 (1), 11408607 (1)
bibp3226 80.9 11 8880067 (3), 9421306 (2), 10658578 (1), 11906964 (1) (see all 6)
[pro...34...]npy 79.7 5 10737675 (2), 8961073 (1)
sr 120819a 77.9 2 10858507 (2)
bibo3304 67.9 1 11906964 (1)
enterogastrone 67 3 9198086 (1), 9200286 (1)
orlistat 53.6 9 18647814 (5)
incretin 50.6 2 19918005 (1), 20380653 (1)
pramlintide 48.1 1 16625817 (1)

Search CenterWatch for drugs/clinical trials and news about PYY

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PYY gene: 
NM_004160.4  

Unigene Cluster for PYY:

Peptide YY
Hs.169249  [show with all ESTs]
Unigene Representative Sequence: BM549164
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000360085(uc002ieq.3 uc002ier.1) ENST00000592796
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PYY
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PYY
SwitchGear 3'UTR luciferase reporter plasmidPYY 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for PYY
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PYY
Clone
Products:
     
OriGene clones in human, mouse for PYY (see all 7)
OriGene ORF clones in mouse, rat for PYY
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PYY (NM_004160)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PYY
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PYY
Sirion Biotech Customized lentivirus for stable overexpression of PYY 
                     Customized lentivirus expression plasmids for stable overexpression of PYY 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for PYY
OriGene qSTAR qPCR primer pairs in human, mouse for PYY
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PYY
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PYY
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PYY

Additional mRNA sequence: 

BC041057.1 CR542129.1 D13899.1 D13902.1 

2 DOTS entries:

DT.452118  DT.87046273 

12 AceView cDNA sequences:

T27212 T27211 NM_004160 D13902 AA913288 AW136574 D13899 CR542129 
BC041057 BM549164 AI654355 AI183955 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for PYY    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:                                                      
SP2:                                                      


ECgene alternative splicing isoforms for PYY

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PYY expression in normal human tissues (normalized intensities)      PYY embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGCTGGAGG
PYY Expression
About this image


PYY expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/6 selected tissues (see all 6) fully expand
 
 Pancreas (Endocrine System)    fully expand to see all 5 entries
         Endocrine Progenitor Cells Ventral Pancreatic Bud
         visceral organ/gut/foregut-midgut junction   
 
 Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
         rectum ; glandular cells   
         colonic mucosal (ibs)   
 
 Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
         small intestine ; glandular cells   
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Endoderm (Gastrulation Derivatives)
         Definitive Endoderm

See PYY Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PYY

SOURCE GeneReport for Unigene cluster: Hs.169249
    SABiosciences Expression via Pathway-Focused PCR Arrays including PYY: 
          Obesity in human mouse rat
          PPAR Targets in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for PYY
OriGene qSTAR qPCR primer pairs in human, mouse for PYY
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PYY
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PYY
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PYY
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PYY

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PYY gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Pyy1 , 5 peptide YY1, 5 76.98(n)1
72.16(a)1
  11 (65.48 cM)5
2172121  NM_145435.11  NP_663410.11 
 1021066765 
chicken
(Gallus gallus)
Aves PPY6
Pancreatic hormone
34(a)
1 ↔ 1
JH375643.1(3865-5037)
lizard
(Anolis carolinensis)
Reptilia PYY6
peptide YY
53(a)
1 ↔ 1
6(77845819-77851118)
zebrafish
(Danio rerio)
Actinopterygii pyya1 peptide YYa 58.42(n)
49.48(a)
  30211  NM_001164371.1  NP_001157843.1 


ENSEMBL Gene Tree for PYY (if available)
TreeFam Gene Tree for PYY (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for PYY gene
NPY2  
4 SIMAP similar genes for PYY using alignment to 1 protein entry:     PYY_HUMAN:
PYY2    PYY3    NPY    PPY

PYY for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for PYY
PGOHUM00000259214 PGOHUM00000260961


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1184 SNPs in PYY are shown (see all 1184)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0474074
----see VAR_0474072 R G mis40--------
rs58205161,2
C--37798564(+) GTGGTG/-GCTCA 1 -- int11Minor allele frequency- -:0.00NA 2
rs346342531,2
C--37805707(+) TTTTT-/TGGGGC 1 -- int13Minor allele frequency- T:0.17NA CSA 6
rs2003647251,2
C--37805708(+) CTTTCC/TTTTTT 1 -- int10--------
rs30802501,2
C--37813843(-) ataaa-/TAAA/T
AAAATAAA
ataaa
2 -- int1 cds10--------
rs114135441,2
C--37814191(+) TTTTTT/-GAGAC 1 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
rs106325641,2
C--37818098(+) TACAC-/ATATACA 1 -- int10--------
rs1485281501,2
--37818105(+) TACATA/GTATAC 1 -- int10--------
rs106325651,2
C--37818123(+) tatat-/AC    
   
/ATAC
acata
1 -- int10--------
rs355620431,2
C--37818124(+) ATATA-/ACCATAT 1 -- int10--------

HapMap Linkage Disequilibrium report for PYY (42030106 - 42081837 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for PYY:    About this table     
Variant IDTypeSubtypePubMed ID
esv2675215CNV Deletion23128226
nsv112219CNV Insertion16902084
nsv833454CNV Loss17160897


Human Gene Mutation Database (HGMD): PYY
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing PYY
DNA2.0 Custom Variant and Variant Library Synthesis for PYY

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 600781   
OMIM disorders: 601665  
20/63 diseases for PYY (see all 63):    About MalaCards
short bowel syndrome    urachal adenocarcinoma    gastroesophageal reflux disease    dumping syndrome
bulimia nervosa    duodenogastric reflux    normal pressure hydrocephalus    prader-willi syndrome
carcinoid syndrome    anorexia nervosa    morbid obesity    eating disorder
constipation    obesity    hydrocephalus    amenorrhea
nephroblastoma    celiac disease    obesity, association with    bone density

7 diseases from the University of Copenhagen DISEASES database for PYY:
Constipation     Diabetes mellitus     Morbid obesity     Prader-Willi syndrome
Diarrhea     Short bowel syndrome     Eating disorder

PYY for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/48 Novoseek inferred disease relationships for PYY gene (see all 48)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
obesity 68.1 92 15855352 (3), 17235527 (3), 15331560 (3), 15657373 (2) (see all 47)
anorexia nervosa 56.9 21 18486583 (2), 17119001 (2), 17054989 (2), 15657373 (1) (see all 11)
bulimia nervosa 53.1 13 15638873 (2), 15820714 (2), 10418705 (2), 2350207 (1) (see all 7)
malabsorption 52.8 5 16756746 (2), 8489548 (1), 18609141 (1), 8345132 (1)
prader-willi syndrome 51.7 6 15754036 (2), 20019130 (2), 17223988 (1), 17596650 (1)
obesity morbid 46.2 2 15855352 (1), 17443025 (1)
short bowel syndrome 43.6 2 19176401 (2)
hypomotility 42.7 1 19864732 (1)
insulin sensitivity 39.8 12 20432813 (2), 16720664 (2), 18317469 (1), 17210210 (1) (see all 7)
carcinoid 38.8 14 7896203 (3), 10029457 (2), 12468356 (2), 17578375 (2) (see all 7)

Genetic Association Database (GAD): PYY
Human Genome Epidemiology (HuGE) Navigator: PYY (17 documents)

Export disorders for PYY gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PYY gene, integrated from 9 sources (see all 654):
(articles sorted by number of sources associating them with PYY)
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  1. Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. (PubMed id 15331560)1, 4, 9 Hung C.C....Farooqi I.S. (2004)
  2. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PubMed id 17235527)1, 4, 9 Siddiq A....Froguel P. (2007)
  3. Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1. (PubMed id 7782089)1, 3, 9 Hort Y....Herzog H. (1995)
  4. Y2 receptor gene variants reduce the risk of hypertension in obese children and adolescents. (PubMed id 18622237)1, 4, 9 Santoro N....Perrone L. (2008)
  5. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PubMed id 17325259)1, 4, 9 Campbell C.D....Hirschhorn J.N. (2007)
  6. Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. (PubMed id 15855352)1, 4, 9 Ma L....Baier L.J. (2005)
  7. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
  8. Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. (PubMed id 20642810)1, 4 Friedlander Y....Siscovick D.S. (2010)
  9. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
  10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5697 HGNC: 9748 AceView: PYY Ensembl:ENSG00000131096 euGenes: HUgn5697
ECgene: PYY H-InvDB: PYY

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PYY Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PYY Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PYY gene:
Search GeneIP for patents involving PYY

Licensable Technologies for PYY gene:
Weizmann Institute:Elongation of PYY Activity
GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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