External Ids for PYY Gene
Previous GeneCards Identifiers for PYY Gene
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
GeneCards Summary for PYY Gene
PYY (Peptide YY) is a Protein Coding gene. Diseases associated with PYY include Short Bowel Syndrome and Eating Disorder. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is NPY.
UniProtKB/Swiss-Prot for PYY Gene
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.