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Aliases for PYURF Gene

Aliases for PYURF Gene

  • PIGY Upstream Reading Frame 2 3 5
  • PIGY Upstream Reading Frame Protein 3 4
  • PREY 3 4
  • Protein PreY, Mitochondrial 3

External Ids for PYURF Gene

Previous GeneCards Identifiers for PYURF Gene

  • GC04M089444

Summaries for PYURF Gene

Entrez Gene Summary for PYURF Gene

  • The product of this gene, which is well-conserved, is encoded by the same bicistronic transcript that encodes phosphatidylinositol glycan anchor biosynthesis, class Y, but the two proteins are unrelated. This gene represents the protein encoded by the upstream open reading frame, while the protein encoded by the downstream open reading frame is represented by GeneID:84992. [provided by RefSeq, Aug 2012]

GeneCards Summary for PYURF Gene

PYURF (PIGY Upstream Reading Frame) is a Protein Coding gene. Diseases associated with PYURF include Lice Infestation and Blount's Disease.

Additional gene information for PYURF Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYURF Gene

Genomics for PYURF Gene

GeneHancer (GH) Regulatory Elements for PYURF Gene

Promoters and enhancers for PYURF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I088522 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 285 2.5 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B CBX5 LOC101929134 PYURF PIGY HERC3
GH04I088525 Enhancer 0.4 Ensembl 550.8 -1.4 -1388 0.4 ZBTB33 MLLT1 LOC101929134 LOC100129137 PIGY PYURF HERC3
GH04I088591 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.2 -68.9 -68942 3.1 PKNOX1 CLOCK ATF1 ZFP64 ARID4B SIN3A ZNF2 ZNF48 YY1 ELK1 HERC3 GC04M088591 LOC100129137 PYURF PIGY FAM13A-AS1 GC04M088685 RNU6-33P
GH04I088608 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -87.8 -87795 6 PKNOX1 SMAD1 RB1 BMI1 FEZF1 ZBTB40 BATF IRF4 ZSCAN5C ATF7 HERC3 LOC100129137 PYURF PIGY NAP1L5 FAM13A-AS1 PPM1K GC04M088591 GC04M088685 RNU6-33P
GH04I088230 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 10.3 +292.4 292439 1.8 NFIC ABCG2 LOC105369192 PPM1K RNU6-112P RNU6ATAC31P HERC3 LOC100129137 PIGY PYURF RNU6-1298P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PYURF on UCSC Golden Path with GeneCards custom track

Genomic Locations for PYURF Gene

Genomic Locations for PYURF Gene
chr4:88,520,978-88,523,813
(GRCh38/hg38)
Size:
2,836 bases
Orientation:
Minus strand
chr4:89,442,136-89,444,964
(GRCh37/hg19)

Genomic View for PYURF Gene

Genes around PYURF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYURF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYURF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYURF Gene

Proteins for PYURF Gene

  • Protein details for PYURF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I23-PREY_HUMAN
    Recommended name:
    Protein preY, mitochondrial
    Protein Accession:
    Q96I23
    Secondary Accessions:
    • B2R571

    Protein attributes for PYURF Gene

    Size:
    114 amino acids
    Molecular mass:
    12655 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • PREY and PIGY, 2 apparently unrelated proteins, are respectively the product of an upstream and a downstream ORF contained in a single bicistronic transcript.

neXtProt entry for PYURF Gene

Post-translational modifications for PYURF Gene

No Post-translational modifications

Other Protein References for PYURF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PYURF Gene

Domains & Families for PYURF Gene

Gene Families for PYURF Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PYURF Gene

Suggested Antigen Peptide Sequences for PYURF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96I23

UniProtKB/Swiss-Prot:

PREY_HUMAN :
  • Belongs to the PREY family.
Family:
  • Belongs to the PREY family.
genes like me logo Genes that share domains with PYURF: view

Function for PYURF Gene

Phenotypes From GWAS Catalog for PYURF Gene

Gene Ontology (GO) - Molecular Function for PYURF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16162815
genes like me logo Genes that share ontologies with PYURF: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PYURF Gene

Localization for PYURF Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYURF Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PYURF gene
Compartment Confidence
mitochondrion 5
nucleus 4
endoplasmic reticulum 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PYURF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IDA 16162815
GO:0005739 mitochondrion IEA --
GO:0005789 endoplasmic reticulum membrane IDA 16162815
genes like me logo Genes that share ontologies with PYURF: view

Pathways & Interactions for PYURF Gene

SuperPathways for PYURF Gene

No Data Available

Gene Ontology (GO) - Biological Process for PYURF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006506 GPI anchor biosynthetic process IMP 16162815
GO:0009893 positive regulation of metabolic process IMP 16162815
genes like me logo Genes that share ontologies with PYURF: view

No data available for Pathways by source and SIGNOR curated interactions for PYURF Gene

Drugs & Compounds for PYURF Gene

No Compound Related Data Available

Transcripts for PYURF Gene

mRNA/cDNA for PYURF Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PYURF Gene

PIGY upstream reading frame:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PYURF Gene

No ASD Table

Relevant External Links for PYURF Gene

GeneLoc Exon Structure for
PYURF
ECgene alternative splicing isoforms for
PYURF

Expression for PYURF Gene

Protein differential expression in normal tissues from HIPED for PYURF Gene

This gene is overexpressed in Heart (45.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PYURF Gene



NURSA nuclear receptor signaling pathways regulating expression of PYURF Gene:

PYURF

SOURCE GeneReport for Unigene cluster for PYURF Gene:

Hs.743393

Evidence on tissue expression from TISSUES for PYURF Gene

  • Liver(4.3)
  • Blood(4.1)
  • Stomach(2.7)
  • Nervous system(2.6)
  • Muscle(2.2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PYURF Gene

Orthologs for PYURF Gene

This gene was present in the common ancestor of chordates.

Orthologs for PYURF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PYURF 33
  • 98.54 (n)
PIGY 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PYURF 33
  • 86.84 (n)
PIGY 34
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PYURF 33 34
  • 86.84 (n)
mouse
(Mus musculus)
Mammalia Pyurf 33 16 34
  • 81.38 (n)
PYURF 34
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pigy 33
  • 78.87 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 63 (a)
OneToMany
-- 34
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves PYURF 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PYURF 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pyurf 33
  • 64.31 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:162634 33
  • 67.14 (n)
PYURF 34
  • 52 (a)
OneToOne
Species where no ortholog for PYURF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYURF Gene

ENSEMBL:
Gene Tree for PYURF (if available)
TreeFam:
Gene Tree for PYURF (if available)

Paralogs for PYURF Gene

No data available for Paralogs for PYURF Gene

Variants for PYURF Gene

Sequence variations from dbSNP and Humsavar for PYURF Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs869025322 pathogenic, Hyperphosphatasia with mental retardation syndrome 6 88,521,653(-) A/G 3_prime_UTR_variant
rs869025323 pathogenic, Hyperphosphatasia with mental retardation syndrome 6 88,523,797(-) C/T 5_prime_UTR_variant
rs143548787 uncertain-significance, not provided 88,521,773(-) G/A/C 3_prime_UTR_variant
rs1000114967 -- 88,524,116(-) A/G upstream_transcript_variant
rs1001758000 -- 88,522,465(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PYURF Gene

Variant ID Type Subtype PubMed ID
nsv980229 CNV duplication 23825009

Variation tolerance for PYURF Gene

Gene Damage Index Score: 0.37; 8.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PYURF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PYURF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYURF Gene

Disorders for PYURF Gene

MalaCards: The human disease database

(5) MalaCards diseases for PYURF Gene - From: DISEASES

Disorder Aliases PubMed IDs
lice infestation
  • infestation by pediculus
blount's disease
  • blount disease, infantile
parasitic ectoparasitic infectious disease
  • ectoparasitism
sarcocystosis
  • sarcosporidiosis
interstitial myocarditis
- elite association - COSMIC cancer census association via MalaCards
Search PYURF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PYURF

genes like me logo Genes that share disorders with PYURF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PYURF Gene

Publications for PYURF Gene

  1. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. (PMID: 16162815) Murakami Y … Kinoshita T (Molecular biology of the cell 2005) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for PYURF Gene

Sources for PYURF Gene

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