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Aliases for PYGO2 Gene

Aliases for PYGO2 Gene

  • Pygopus Family PHD Finger 2 2 3 5
  • Pygopus Homolog 2 (Drosophila) 2
  • Pygopus Homolog 2 3
  • 1190004M21Rik 3
  • Pygopus 2 3

External Ids for PYGO2 Gene

Previous GeneCards Identifiers for PYGO2 Gene

  • GC01P148193
  • GC01M150660
  • GC01M151704
  • GC01M152146
  • GC01M151742
  • GC01M153196
  • GC01M154929
  • GC01M126291

Summaries for PYGO2 Gene

GeneCards Summary for PYGO2 Gene

PYGO2 (Pygopus Family PHD Finger 2) is a Protein Coding gene. Diseases associated with PYGO2 include Oligospermia and Treacher Collins Syndrome 1. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Signaling by Wnt. GO annotations related to this gene include chromatin binding and histone acetyltransferase regulator activity. An important paralog of this gene is PYGO1.

UniProtKB/Swiss-Prot for PYGO2 Gene

  • Involved in signal transduction through the Wnt pathway.

Gene Wiki entry for PYGO2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYGO2 Gene

Genomics for PYGO2 Gene

Regulatory Elements for PYGO2 Gene

Enhancers for PYGO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F154324 1.5 FANTOM5 ENCODE 43.5 +636.7 636738 5.7 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143 CHTOP LOC101928120 INTS3 THBS3 PYGO2 SLC27A3 RUSC1-AS1 DPM3 ENSG00000272654 ENSG00000238279
GH01F155242 1.2 ENCODE 52.2 -280.4 -280390 2.9 CREB3L1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 KIAA0907 ENSG00000271267 MSTO2P RUSC1-AS1 THBS3 ASH1L PYGO2 LOC101928120 KRTCAP2 GBA
GH01F155222 1.2 ENCODE 41.2 -261.9 -261878 5.9 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 KIAA0907 ENSG00000271267 MSTO2P THBS3 LOC101928120 PYGO2 GBAP1 ASH1L DPM3 RUSC1-AS1
GH01F155856 1.5 FANTOM5 ENCODE 27.2 -895.1 -895097 5.7 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 RRNAD1 KIAA0907 ENSG00000271267 MSTO2P THBS3 ASH1L-AS1 LOC101928120 PYGO2 KRTCAP2 DCST1
GH01F155123 1.5 FANTOM5 ENCODE 26.2 -164.2 -164170 8.7 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FOS LOC101928120 MSTO2P PYGO2 KIAA0907 ASH1L GBAP1 EFNA1 DPM3 TDRD10 ASH1L-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PYGO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PYGO2 Gene

Chromosome:
1
Start:
154,957,026 bp from pter
End:
154,963,853 bp from pter
Size:
6,828 bases
Orientation:
Minus strand

Genomic View for PYGO2 Gene

Genes around PYGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYGO2 Gene

Proteins for PYGO2 Gene

  • Protein details for PYGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRQ0-PYGO2_HUMAN
    Recommended name:
    Pygopus homolog 2
    Protein Accession:
    Q9BRQ0
    Secondary Accessions:
    • Q8WYZ4
    • Q96CY2

    Protein attributes for PYGO2 Gene

    Size:
    406 amino acids
    Molecular mass:
    41244 Da
    Quaternary structure:
    • Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex.
    SequenceCaution:
    • Sequence=AAL55782.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PYGO2 Gene

neXtProt entry for PYGO2 Gene

Post-translational modifications for PYGO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PYGO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for PYGO2

No data available for DME Specific Peptides for PYGO2 Gene

Domains & Families for PYGO2 Gene

Gene Families for PYGO2 Gene

Suggested Antigen Peptide Sequences for PYGO2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BRQ0

UniProtKB/Swiss-Prot:

PYGO2_HUMAN :
  • Contains 1 PHD-type zinc finger.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with PYGO2: view

Function for PYGO2 Gene

Molecular function for PYGO2 Gene

UniProtKB/Swiss-Prot Function:
Involved in signal transduction through the Wnt pathway.

Gene Ontology (GO) - Molecular Function for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001105 contributes_to RNA polymerase II transcription coactivator activity IBA --
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IPI 17113272
GO:0008270 zinc ion binding IEA --
GO:0035034 histone acetyltransferase regulator activity IBA --
genes like me logo Genes that share ontologies with PYGO2: view
genes like me logo Genes that share phenotypes with PYGO2: view

Animal Models for PYGO2 Gene

MGI Knock Outs for PYGO2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PYGO2 Gene

Localization for PYGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYGO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PYGO2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PYGO2: view

Pathways & Interactions for PYGO2 Gene

genes like me logo Genes that share pathways with PYGO2: view

Gene Ontology (GO) - Biological Process for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001822 kidney development IBA --
GO:0002088 lens development in camera-type eye IEA --
GO:0007286 spermatid development IEA --
GO:0007289 spermatid nucleus differentiation IBA --
genes like me logo Genes that share ontologies with PYGO2: view

No data available for SIGNOR curated interactions for PYGO2 Gene

Transcripts for PYGO2 Gene

mRNA/cDNA for PYGO2 Gene

Unigene Clusters for PYGO2 Gene

Pygopus homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYGO2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for PYGO2 Gene

GeneLoc Exon Structure for
PYGO2
ECgene alternative splicing isoforms for
PYGO2

Expression for PYGO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PYGO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PYGO2 Gene

This gene is overexpressed in CD4 Tcells (20.3), Placenta (17.9), Peripheral blood mononuclear cells (16.1), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PYGO2 Gene



Protein tissue co-expression partners for PYGO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PYGO2 Gene:

PYGO2

SOURCE GeneReport for Unigene cluster for PYGO2 Gene:

Hs.533597
genes like me logo Genes that share expression patterns with PYGO2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PYGO2 Gene

Orthologs for PYGO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PYGO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PYGO2 34 35
  • 99.75 (n)
oppossum
(Monodelphis domestica)
Mammalia PYGO2 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PYGO2 34 35
  • 93.5 (n)
dog
(Canis familiaris)
Mammalia PYGO2 34 35
  • 92.1 (n)
rat
(Rattus norvegicus)
Mammalia Pygo2 34
  • 89.05 (n)
mouse
(Mus musculus)
Mammalia Pygo2 34 16 35
  • 88.59 (n)
chicken
(Gallus gallus)
Aves LOC100857999 34
  • 75.41 (n)
PYGO2 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PYGO2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11797 34
zebrafish
(Danio rerio)
Actinopterygii pygo2 35
  • 35 (a)
OneToOne
wufc56f02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3192 34
fruit fly
(Drosophila melanogaster)
Insecta pygo 35
  • 12 (a)
OneToMany
Species where no ortholog for PYGO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYGO2 Gene

ENSEMBL:
Gene Tree for PYGO2 (if available)
TreeFam:
Gene Tree for PYGO2 (if available)

Paralogs for PYGO2 Gene

Paralogs for PYGO2 Gene

(1) SIMAP similar genes for PYGO2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PYGO2: view

Variants for PYGO2 Gene

Sequence variations from dbSNP and Humsavar for PYGO2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1050947 -- 154,963,029(-) ACTCT(A/G)CGCCA downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs111936177 -- 154,960,264(+) CGTCT(C/G)AAAAA intron-variant, upstream-variant-2KB
rs112127184 -- 154,957,760(+) CCGCC(A/G)CATCC upstream-variant-2KB, utr-variant-3-prime
rs112662266 -- 154,961,028(+) AGACC(G/T)GGAAG upstream-variant-2KB, splice-acceptor-variant
rs113804194 -- 154,962,789(+) GGAAA(A/G)TAAGT downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PYGO2 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV insertion 20534489

Variation tolerance for PYGO2 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PYGO2 Gene

Human Gene Mutation Database (HGMD)
PYGO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PYGO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYGO2 Gene

Disorders for PYGO2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PYGO2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
oligospermia
treacher collins syndrome 1
  • treacher collins syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PYGO2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PYGO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PYGO2
genes like me logo Genes that share disorders with PYGO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PYGO2 Gene

Publications for PYGO2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. A new nuclear component of the Wnt signalling pathway. (PMID: 11988739) Thompson B. … Bienz M. (Nat. Cell Biol. 2002) 2 3 64
  4. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. (PMID: 11955446) Kramps T. … Basler K. (Cell 2002) 3 4 64
  5. Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation. (PMID: 26170450) Li Q. … Dai X. (J. Biol. Chem. 2015) 3 64

Products for PYGO2 Gene

Sources for PYGO2 Gene

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