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Aliases for PYGO2 Gene

Aliases for PYGO2 Gene

  • Pygopus Family PHD Finger 2 2 3 5
  • Pygopus Homolog 2 (Drosophila) 2
  • 1190004M21Rik 3
  • Pygopus 2 3

External Ids for PYGO2 Gene

Previous GeneCards Identifiers for PYGO2 Gene

  • GC01P148193
  • GC01M150660
  • GC01M151704
  • GC01M152146
  • GC01M151742
  • GC01M153196
  • GC01M154929
  • GC01M126291

Summaries for PYGO2 Gene

GeneCards Summary for PYGO2 Gene

PYGO2 (Pygopus Family PHD Finger 2) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and WNT Signaling. GO annotations related to this gene include chromatin binding and histone acetyltransferase regulator activity. An important paralog of this gene is PYGO1.

UniProtKB/Swiss-Prot for PYGO2 Gene

  • Involved in signal transduction through the Wnt pathway.

Gene Wiki entry for PYGO2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYGO2 Gene

Genomics for PYGO2 Gene

Regulatory Elements for PYGO2 Gene

Enhancers for PYGO2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PYGO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PYGO2 Gene

154,957,026 bp from pter
154,963,853 bp from pter
6,828 bases
Minus strand

Genomic View for PYGO2 Gene

Genes around PYGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYGO2 Gene

Proteins for PYGO2 Gene

  • Protein details for PYGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pygopus homolog 2
    Protein Accession:
    Secondary Accessions:
    • Q8WYZ4
    • Q96CY2

    Protein attributes for PYGO2 Gene

    406 amino acids
    Molecular mass:
    41244 Da
    Quaternary structure:
    • Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex.
    • Sequence=AAL55782.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PYGO2 Gene

neXtProt entry for PYGO2 Gene

Proteomics data for PYGO2 Gene at MOPED

Post-translational modifications for PYGO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PYGO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for PYGO2

No data available for DME Specific Peptides for PYGO2 Gene

Domains & Families for PYGO2 Gene

Gene Families for PYGO2 Gene

Suggested Antigen Peptide Sequences for PYGO2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PHD-type zinc finger.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with PYGO2: view

Function for PYGO2 Gene

Molecular function for PYGO2 Gene

UniProtKB/Swiss-Prot Function:
Involved in signal transduction through the Wnt pathway.

Gene Ontology (GO) - Molecular Function for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042393 histone binding IEA --
genes like me logo Genes that share ontologies with PYGO2: view
genes like me logo Genes that share phenotypes with PYGO2: view

Animal Models for PYGO2 Gene

MGI Knock Outs for PYGO2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PYGO2 Gene

Localization for PYGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYGO2 Gene

Subcellular locations from

Jensen Localization Image for PYGO2 Gene COMPARTMENTS Subcellular localization image for PYGO2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for PYGO2 Gene

Pathways & Interactions for PYGO2 Gene

genes like me logo Genes that share pathways with PYGO2: view

Gene Ontology (GO) - Biological Process for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001822 kidney development IEA --
GO:0007286 spermatid development IEA --
GO:0007289 spermatid nucleus differentiation IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with PYGO2: view

No data available for SIGNOR curated interactions for PYGO2 Gene

Drugs & Compounds for PYGO2 Gene

No Compound Related Data Available

Transcripts for PYGO2 Gene

mRNA/cDNA for PYGO2 Gene

Unigene Clusters for PYGO2 Gene

Pygopus homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PYGO2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -

Relevant External Links for PYGO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PYGO2 Gene

mRNA expression in normal human tissues for PYGO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PYGO2 Gene

This gene is overexpressed in CD4 Tcells (20.3), Placenta (17.9), Peripheral blood mononuclear cells (16.1), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PYGO2 Gene

SOURCE GeneReport for Unigene cluster for PYGO2 Gene Hs.533597

genes like me logo Genes that share expression patterns with PYGO2: view

Protein tissue co-expression partners for PYGO2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PYGO2 Gene

Orthologs for PYGO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PYGO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PYGO2 35
  • 93.5 (n)
  • 98.27 (a)
PYGO2 36
  • 98 (a)
(Canis familiaris)
Mammalia PYGO2 35
  • 92.1 (n)
  • 97.04 (a)
PYGO2 36
  • 97 (a)
(Mus musculus)
Mammalia Pygo2 35
  • 88.59 (n)
  • 96.74 (a)
Pygo2 16
Pygo2 36
  • 97 (a)
(Pan troglodytes)
Mammalia PYGO2 35
  • 99.75 (n)
  • 99.75 (a)
PYGO2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pygo2 35
  • 89.05 (n)
  • 96.54 (a)
(Monodelphis domestica)
Mammalia PYGO2 36
  • 96 (a)
(Gallus gallus)
Aves LOC100857999 35
  • 75.41 (n)
  • 82.3 (a)
PYGO2 36
  • 73 (a)
(Anolis carolinensis)
Reptilia PYGO2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11797 35
(Danio rerio)
Actinopterygii wufc56f02 35
pygo2 36
  • 35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3192 35
fruit fly
(Drosophila melanogaster)
Insecta pygo 36
  • 12 (a)
Species with no ortholog for PYGO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYGO2 Gene

Gene Tree for PYGO2 (if available)
Gene Tree for PYGO2 (if available)

Paralogs for PYGO2 Gene

Paralogs for PYGO2 Gene

(1) SIMAP similar genes for PYGO2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PYGO2: view

Variants for PYGO2 Gene

Sequence variations from dbSNP and Humsavar for PYGO2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2456269 -- 154,959,550(+) GGACC(A/C)TGGGG reference, missense
rs61758741 -- 154,959,219(+) GGGCT(C/T)CCCCC reference, missense
rs139768764 -- 154,958,243(+) AAGGA(A/G)TGGGT utr-variant-3-prime
rs116588813 -- 154,958,782(+) CGTCA(C/T)CCATC reference, synonymous-codon
rs141722381 -- 154,959,281(+) TTGTG(A/T)TAGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PYGO2 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872453 CNV Loss 21882294
nsv872454 CNV Loss 21882294

Variation tolerance for PYGO2 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PYGO2 Gene

Disorders for PYGO2 Gene

Relevant External Links for PYGO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PYGO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PYGO2 Gene

Publications for PYGO2 Gene

  1. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. A new nuclear component of the Wnt signalling pathway. (PMID: 11988739) Thompson B. … Bienz M. (Nat. Cell Biol. 2002) 2 3
  3. Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression. (PMID: 25871475) Zhang S. … Wang X. (Oncotarget 2015) 3
  4. Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation. (PMID: 26170450) Li Q. … Dai X. (J. Biol. Chem. 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PYGO2 Gene

Sources for PYGO2 Gene