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Aliases for PYGO1 Gene

Aliases for PYGO1 Gene

  • Pygopus Family PHD Finger 1 2 3 5
  • Pygopus Homolog 1 (Drosophila) 2

External Ids for PYGO1 Gene

Previous GeneCards Identifiers for PYGO1 Gene

  • GC15M051396
  • GC15M048883
  • GC15M053417
  • GC15M053554
  • GC15M053625
  • GC15M055831
  • GC15M032662

Summaries for PYGO1 Gene

GeneCards Summary for PYGO1 Gene

PYGO1 (Pygopus Family PHD Finger 1) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and Signaling by GPCR. An important paralog of this gene is PYGO2.

UniProtKB/Swiss-Prot for PYGO1 Gene

  • Involved in signal transduction through the Wnt pathway.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYGO1 Gene

Genomics for PYGO1 Gene

Regulatory Elements for PYGO1 Gene

Enhancers for PYGO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G056037 1.7 FANTOM5 Ensembl ENCODE 10.6 -452.0 -452035 6.5 PKNOX1 FOXA2 MLX FEZF1 DMAP1 ZNF2 YY1 ZNF766 FOS DEK PRTG RSL24D1 PYGO1 RN7SL568P CD24P2
GH15G055401 1.2 ENCODE 11.6 +183.4 183388 7.7 CREB3L1 AGO1 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D RSL24D1 PYGO1 DNAAF4 C15orf65 PIGB CCPG1 GC15M056539
GH15G055627 1.1 Ensembl ENCODE 12.2 -39.2 -39155 1.6 PKNOX1 BRCA1 RFX5 ZSCAN5C RCOR1 FOS SMARCC1 YY2 USF2 CEBPB PRTG PYGO1 ENSG00000259180
GH15G055497 1 ENCODE 11.6 +90.5 90513 1.4 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GTF3C2 ZNF143 MXD4 ZNF518A RSL24D1 PYGO1 C15orf65 PIGB DNAAF4 DNAAF4-CCPG1 LOC100420711
GH15G055648 1 Ensembl ENCODE 11 -59.7 -59654 0.4 GTF2F1 CTCF ZNF2 RAD21 RFX5 ZNF143 SMC3 MAFK STAT1 ZNF654 PYGO1 ENSG00000259180
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PYGO1 on UCSC Golden Path with GeneCards custom track

Promoters for PYGO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076837 847 1801 CTCF MXI1 SUZ12 ZNF76 SIN3A ZNF664 E2F1 ZFHX2 GATA3 ZBTB48

Genomic Location for PYGO1 Gene

Chromosome:
15
Start:
55,538,884 bp from pter
End:
55,588,947 bp from pter
Size:
50,064 bases
Orientation:
Minus strand

Genomic View for PYGO1 Gene

Genes around PYGO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYGO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYGO1 Gene

Proteins for PYGO1 Gene

  • Protein details for PYGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3Y4-PYGO1_HUMAN
    Recommended name:
    Pygopus homolog 1
    Protein Accession:
    Q9Y3Y4
    Secondary Accessions:
    • A7Y2D6

    Protein attributes for PYGO1 Gene

    Size:
    419 amino acids
    Molecular mass:
    45116 Da
    Quaternary structure:
    • Interacts with BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Identified in a complex with BCL9L, CDC73, CTNNB1 and PYGO1. Interacts with histone H3 mono-, di- or tri-methylated at Lys4 (H3K4me1, H3K4me2, H3K4me3); the interaction is enhanced by the interaction with BCL9.

    Three dimensional structures from OCA and Proteopedia for PYGO1 Gene

    Alternative splice isoforms for PYGO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PYGO1 Gene

Post-translational modifications for PYGO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PYGO1 Gene

No data available for DME Specific Peptides for PYGO1 Gene

Domains & Families for PYGO1 Gene

Gene Families for PYGO1 Gene

Suggested Antigen Peptide Sequences for PYGO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PYGO1: view

No data available for UniProtKB/Swiss-Prot for PYGO1 Gene

Function for PYGO1 Gene

Molecular function for PYGO1 Gene

UniProtKB/Swiss-Prot Function:
Involved in signal transduction through the Wnt pathway.

Gene Ontology (GO) - Molecular Function for PYGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18498752
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PYGO1: view
genes like me logo Genes that share phenotypes with PYGO1: view

Animal Models for PYGO1 Gene

MGI Knock Outs for PYGO1:

Animal Model Products

miRNA for PYGO1 Gene

miRTarBase miRNAs that target PYGO1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PYGO1 Gene

Localization for PYGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYGO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PYGO1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PYGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PYGO1: view

Pathways & Interactions for PYGO1 Gene

genes like me logo Genes that share pathways with PYGO1: view

SIGNOR curated interactions for PYGO1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PYGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0007286 spermatid development IEA --
GO:0007289 spermatid nucleus differentiation IEA --
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with PYGO1: view

Drugs & Compounds for PYGO1 Gene

No Compound Related Data Available

Transcripts for PYGO1 Gene

mRNA/cDNA for PYGO1 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PYGO1 Gene

Pygopus homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYGO1 Gene

No ASD Table

Relevant External Links for PYGO1 Gene

GeneLoc Exon Structure for
PYGO1
ECgene alternative splicing isoforms for
PYGO1

Expression for PYGO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PYGO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PYGO1 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for PYGO1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PYGO1 Gene



Protein tissue co-expression partners for PYGO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PYGO1 Gene:

PYGO1

SOURCE GeneReport for Unigene cluster for PYGO1 Gene:

Hs.256587

Evidence on tissue expression from TISSUES for PYGO1 Gene

  • Nervous system(4.2)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with PYGO1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PYGO1 Gene

Orthologs for PYGO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PYGO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PYGO1 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia PYGO1 34 35
  • 93.79 (n)
cow
(Bos Taurus)
Mammalia PYGO1 34 35
  • 93.01 (n)
oppossum
(Monodelphis domestica)
Mammalia PYGO1 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pygo1 34 16 35
  • 82.91 (n)
rat
(Rattus norvegicus)
Mammalia Pygo1 34
  • 82.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PYGO1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PYGO1 34 35
  • 73.59 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia pygo1 34
  • 58.24 (n)
zebrafish
(Danio rerio)
Actinopterygii pygo1 34 35
  • 56.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta pygo 35
  • 10 (a)
OneToMany
Species where no ortholog for PYGO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYGO1 Gene

ENSEMBL:
Gene Tree for PYGO1 (if available)
TreeFam:
Gene Tree for PYGO1 (if available)

Paralogs for PYGO1 Gene

Paralogs for PYGO1 Gene

(1) SIMAP similar genes for PYGO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PYGO1: view

Variants for PYGO1 Gene

Sequence variations from dbSNP and Humsavar for PYGO1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000039991 -- 55,545,578(+) TTCCC(C/T)CATGT intron-variant, utr-variant-3-prime
rs1000085955 -- 55,583,856(+) AACTG(C/T)CTTCT intron-variant
rs1000086479 -- 55,583,126(+) CTTCC(A/G)TGTGT intron-variant
rs1000150414 -- 55,582,550(+) TTCAA(C/T)GCTTT intron-variant
rs1000163234 -- 55,565,697(+) TGACA(-/GAGT)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PYGO1 Gene

Variant ID Type Subtype PubMed ID
esv2761899 CNV gain+loss 21179565
esv3569609 CNV gain 25503493
nsv1043789 CNV gain 25217958
nsv472724 CNV novel sequence insertion 20440878
nsv569523 CNV gain 21841781
nsv569539 CNV loss 21841781
nsv569540 CNV gain 21841781
nsv833016 CNV gain 17160897
nsv94482 CNV deletion 16902084
nsv951965 CNV duplication 24416366

Variation tolerance for PYGO1 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PYGO1 Gene

Human Gene Mutation Database (HGMD)
PYGO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PYGO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYGO1 Gene

Disorders for PYGO1 Gene

Relevant External Links for PYGO1

Genetic Association Database (GAD)
PYGO1
Human Genome Epidemiology (HuGE) Navigator
PYGO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PYGO1

No disorders were found for PYGO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PYGO1 Gene

Publications for PYGO1 Gene

  1. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PMID: 20403915) Frank B. … Brenner H. (Carcinogenesis 2010) 3 46 64
  2. Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. (PMID: 18498752) Fiedler M. … Bienz M. (Mol. Cell 2008) 3 4 64
  3. A new nuclear component of the Wnt signalling pathway. (PMID: 11988739) Thompson B. … Bienz M. (Nat. Cell Biol. 2002) 2 3 64
  4. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. (PMID: 11955446) Kramps T. … Basler K. (Cell 2002) 3 4 64
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64

Products for PYGO1 Gene

Sources for PYGO1 Gene

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