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Aliases for PYGO1 Gene

Aliases for PYGO1 Gene

  • Pygopus Family PHD Finger 1 2 3 5
  • Pygopus Homolog 1 (Drosophila) 2

External Ids for PYGO1 Gene

Previous GeneCards Identifiers for PYGO1 Gene

  • GC15M051396
  • GC15M048883
  • GC15M053417
  • GC15M053554
  • GC15M053625
  • GC15M055831
  • GC15M032662

Summaries for PYGO1 Gene

GeneCards Summary for PYGO1 Gene

PYGO1 (Pygopus Family PHD Finger 1) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Signaling by Wnt. An important paralog of this gene is PYGO2.

UniProtKB/Swiss-Prot for PYGO1 Gene

  • Involved in signal transduction through the Wnt pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYGO1 Gene

Genomics for PYGO1 Gene

Regulatory Elements for PYGO1 Gene

Enhancers for PYGO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F055401 1.2 ENCODE 11.6 +183.4 183388 7.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 RSL24D1 PYGO1 DYX1C1 C15orf65 PIGB CCPG1 MIR628 GC15M055985
GH15F055627 1.1 Ensembl ENCODE 12.2 -39.2 -39155 1.6 GTF2F1 CTCF MXI1 PKNOX1 JUN MAX BRCA1 RFX5 HIC1 ZBTB48 PRTG PYGO1 ENSG00000259180
GH15F055497 1 ENCODE 11.6 +90.5 90513 1.4 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GTF3C2 ZNF143 MXD4 ZNF518A RSL24D1 PYGO1 C15orf65 PIGB DYX1C1 DYX1C1-CCPG1 LOC100420711
GH15F055791 1 Ensembl ENCODE 9.8 -203.1 -203095 1.8 TBP MXI1 ZNF146 TAF1 JUN MAX PRDM10 FOS CHD2 STAT1 PRTG PYGO1 RSL24D1 GC15P055749 NEDD4
GH15F055652 0.8 ENCODE 10.4 -63.6 -63611 0.2 ELF3 SOX13 ARID4B CEBPG ZNF644 KMT2B RARA HOMEZ THAP11 GATAD2A PRTG PYGO1 ENSG00000259180
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PYGO1 on UCSC Golden Path with GeneCards custom track

Promoters for PYGO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000408286 747 2800 CTCF ZNF76 CHD4 SIN3A E2F1 ZNF664 ZFHX2 GATA3 ZBTB48 POLR2A

Genomic Location for PYGO1 Gene

55,538,884 bp from pter
55,588,947 bp from pter
50,064 bases
Minus strand

Genomic View for PYGO1 Gene

Genes around PYGO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYGO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYGO1 Gene

Proteins for PYGO1 Gene

  • Protein details for PYGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pygopus homolog 1
    Protein Accession:
    Secondary Accessions:
    • A7Y2D6

    Protein attributes for PYGO1 Gene

    419 amino acids
    Molecular mass:
    45116 Da
    Quaternary structure:
    • Interacts with BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Identified in a complex with BCL9L, CDC73, CTNNB1 and PYGO1. Interacts with histone H3 mono-, di- or tri-methylated at Lys4 (H3K4me1, H3K4me2, H3K4me3); the interaction is enhanced by the interaction with BCL9.

    Three dimensional structures from OCA and Proteopedia for PYGO1 Gene

    Alternative splice isoforms for PYGO1 Gene


neXtProt entry for PYGO1 Gene

Post-translational modifications for PYGO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PYGO1 Gene

Antibody Products

  • Abcam antibodies for PYGO1
  • Cloud-Clone Corp. Antibodies for PYGO1

No data available for DME Specific Peptides for PYGO1 Gene

Domains & Families for PYGO1 Gene

Gene Families for PYGO1 Gene

Suggested Antigen Peptide Sequences for PYGO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PHD-type zinc finger.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with PYGO1: view

Function for PYGO1 Gene

Molecular function for PYGO1 Gene

UniProtKB/Swiss-Prot Function:
Involved in signal transduction through the Wnt pathway.

Gene Ontology (GO) - Molecular Function for PYGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001105 contributes_to RNA polymerase II transcription coactivator activity IBA --
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IPI 18498752
GO:0008270 zinc ion binding IEA --
GO:0035034 histone acetyltransferase regulator activity IBA --
genes like me logo Genes that share ontologies with PYGO1: view
genes like me logo Genes that share phenotypes with PYGO1: view

Animal Models for PYGO1 Gene

MGI Knock Outs for PYGO1:

Animal Model Products

miRNA for PYGO1 Gene

miRTarBase miRNAs that target PYGO1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PYGO1 Gene

Localization for PYGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYGO1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PYGO1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PYGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PYGO1: view

Pathways & Interactions for PYGO1 Gene

genes like me logo Genes that share pathways with PYGO1: view

SIGNOR curated interactions for PYGO1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PYGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IBA --
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0007286 spermatid development IEA --
GO:0007289 spermatid nucleus differentiation IBA --
GO:0009791 post-embryonic development IBA --
genes like me logo Genes that share ontologies with PYGO1: view

Transcripts for PYGO1 Gene

mRNA/cDNA for PYGO1 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PYGO1 Gene

Pygopus homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYGO1 Gene

No ASD Table

Relevant External Links for PYGO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PYGO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PYGO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PYGO1 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for PYGO1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PYGO1 Gene

Protein tissue co-expression partners for PYGO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PYGO1 Gene:


SOURCE GeneReport for Unigene cluster for PYGO1 Gene:

genes like me logo Genes that share expression patterns with PYGO1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PYGO1 Gene

Orthologs for PYGO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PYGO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PYGO1 34 35
  • 99.67 (n)
(Canis familiaris)
Mammalia PYGO1 34 35
  • 93.79 (n)
(Bos Taurus)
Mammalia PYGO1 34 35
  • 93.01 (n)
(Monodelphis domestica)
Mammalia PYGO1 35
  • 86 (a)
(Mus musculus)
Mammalia Pygo1 34 16 35
  • 82.91 (n)
(Rattus norvegicus)
Mammalia Pygo1 34
  • 82.48 (n)
(Ornithorhynchus anatinus)
Mammalia PYGO1 35
  • 74 (a)
(Gallus gallus)
Aves PYGO1 34 35
  • 73.59 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia pygo1 34
  • 58.24 (n)
(Danio rerio)
Actinopterygii pygo1 34 35
  • 56.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta pygo 35
  • 10 (a)
Species where no ortholog for PYGO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYGO1 Gene

Gene Tree for PYGO1 (if available)
Gene Tree for PYGO1 (if available)

Paralogs for PYGO1 Gene

Paralogs for PYGO1 Gene

(1) SIMAP similar genes for PYGO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PYGO1: view

Variants for PYGO1 Gene

Sequence variations from dbSNP and Humsavar for PYGO1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10083592 -- 55,565,533(+) acccc(A/G)tctct intron-variant
rs1051506 -- 55,541,103(-) AAACT(C/T)AGTGG utr-variant-3-prime
rs10648446 -- 55,576,760(+) AGATC(-/AAAA/AAAAAAAAAAA/AAAAAAAAAAAAAAAAAA)AAAAA intron-variant
rs11071188 -- 55,544,701(+) TTGCA(A/G)TGATA utr-variant-3-prime
rs11071189 -- 55,544,890(+) CCCTC(A/G)AGAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PYGO1 Gene

Variant ID Type Subtype PubMed ID
nsv951965 CNV duplication 24416366
nsv94482 CNV deletion 16902084
nsv833016 CNV gain 17160897
nsv569540 CNV gain 21841781
nsv569539 CNV loss 21841781
nsv569523 CNV gain 21841781
nsv472724 CNV novel sequence insertion 20440878
nsv1043789 CNV gain 25217958
esv3569609 CNV gain 25503493
esv2761899 CNV gain+loss 21179565

Variation tolerance for PYGO1 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PYGO1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYGO1 Gene

Disorders for PYGO1 Gene

Relevant External Links for PYGO1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PYGO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PYGO1 Gene

Publications for PYGO1 Gene

  1. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PMID: 20403915) Frank B. … Brenner H. (Carcinogenesis 2010) 3 46 64
  2. Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. (PMID: 18498752) Fiedler M. … Bienz M. (Mol. Cell 2008) 3 4 64
  3. A new nuclear component of the Wnt signalling pathway. (PMID: 11988739) Thompson B. … Bienz M. (Nat. Cell Biol. 2002) 2 3 64
  4. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. (PMID: 11955446) Kramps T. … Basler K. (Cell 2002) 3 4 64
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64

Products for PYGO1 Gene

Sources for PYGO1 Gene

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