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Aliases for PYGO1 Gene

Aliases for PYGO1 Gene

  • Pygopus Family PHD Finger 1 2 3 5
  • Pygopus Homolog 1 (Drosophila) 2

External Ids for PYGO1 Gene

Previous GeneCards Identifiers for PYGO1 Gene

  • GC15M051396
  • GC15M048883
  • GC15M053417
  • GC15M053554
  • GC15M053625
  • GC15M055831
  • GC15M032662

Summaries for PYGO1 Gene

GeneCards Summary for PYGO1 Gene

PYGO1 (Pygopus Family PHD Finger 1) is a Protein Coding gene. Diseases associated with PYGO1 include acute diarrhea. Among its related pathways are Signaling by GPCR and Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways. An important paralog of this gene is PYGO2.

UniProtKB/Swiss-Prot for PYGO1 Gene

  • Involved in signal transduction through the Wnt pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYGO1 Gene

Genomics for PYGO1 Gene

Regulatory Elements for PYGO1 Gene

Promoters for PYGO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PYGO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PYGO1 Gene

Chromosome:
15
Start:
55,538,884 bp from pter
End:
55,588,947 bp from pter
Size:
50,064 bases
Orientation:
Minus strand

Genomic View for PYGO1 Gene

Genes around PYGO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYGO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYGO1 Gene

Proteins for PYGO1 Gene

  • Protein details for PYGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3Y4-PYGO1_HUMAN
    Recommended name:
    Pygopus homolog 1
    Protein Accession:
    Q9Y3Y4
    Secondary Accessions:
    • A7Y2D6

    Protein attributes for PYGO1 Gene

    Size:
    419 amino acids
    Molecular mass:
    45116 Da
    Quaternary structure:
    • Interacts with BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Identified in a complex with BCL9L, CDC73, CTNNB1 and PYGO1. Interacts with histone H3 mono-, di- or tri-methylated at Lys4 (H3K4me1, H3K4me2, H3K4me3); the interaction is enhanced by the interaction with BCL9.

    Three dimensional structures from OCA and Proteopedia for PYGO1 Gene

    Alternative splice isoforms for PYGO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PYGO1 Gene

Proteomics data for PYGO1 Gene at MOPED

Post-translational modifications for PYGO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PYGO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for PYGO1

No data available for DME Specific Peptides for PYGO1 Gene

Domains & Families for PYGO1 Gene

Gene Families for PYGO1 Gene

Suggested Antigen Peptide Sequences for PYGO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3Y4

UniProtKB/Swiss-Prot:

PYGO1_HUMAN :
  • Contains 1 PHD-type zinc finger.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with PYGO1: view

Function for PYGO1 Gene

Molecular function for PYGO1 Gene

UniProtKB/Swiss-Prot Function:
Involved in signal transduction through the Wnt pathway.

Gene Ontology (GO) - Molecular Function for PYGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 18498752
genes like me logo Genes that share ontologies with PYGO1: view
genes like me logo Genes that share phenotypes with PYGO1: view

Animal Models for PYGO1 Gene

MGI Knock Outs for PYGO1:

Animal Model Products

miRNA for PYGO1 Gene

miRTarBase miRNAs that target PYGO1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PYGO1 Gene

Localization for PYGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYGO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PYGO1 Gene COMPARTMENTS Subcellular localization image for PYGO1 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for PYGO1 Gene

Pathways & Interactions for PYGO1 Gene

genes like me logo Genes that share pathways with PYGO1: view

SIGNOR curated interactions for PYGO1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PYGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0007286 spermatid development IEA --
GO:0007289 spermatid nucleus differentiation IEA --
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with PYGO1: view

Drugs & Compounds for PYGO1 Gene

No Compound Related Data Available

Transcripts for PYGO1 Gene

mRNA/cDNA for PYGO1 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PYGO1 Gene

Pygopus homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PYGO1 Gene

No ASD Table

Relevant External Links for PYGO1 Gene

GeneLoc Exon Structure for
PYGO1
ECgene alternative splicing isoforms for
PYGO1

Expression for PYGO1 Gene

mRNA expression in normal human tissues for PYGO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PYGO1 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for PYGO1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PYGO1 Gene



SOURCE GeneReport for Unigene cluster for PYGO1 Gene Hs.256587

genes like me logo Genes that share expression patterns with PYGO1: view

Protein tissue co-expression partners for PYGO1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PYGO1 Gene

Orthologs for PYGO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PYGO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PYGO1 35
  • 93.01 (n)
  • 95.65 (a)
PYGO1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PYGO1 35
  • 93.79 (n)
  • 96.43 (a)
PYGO1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pygo1 35
  • 82.91 (n)
  • 90 (a)
Pygo1 16
Pygo1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PYGO1 35
  • 99.67 (n)
  • 99.25 (a)
PYGO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pygo1 35
  • 82.48 (n)
  • 89.23 (a)
oppossum
(Monodelphis domestica)
Mammalia PYGO1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PYGO1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PYGO1 35
  • 73.59 (n)
  • 69.57 (a)
PYGO1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pygo1 35
  • 58.24 (n)
  • 43.89 (a)
zebrafish
(Danio rerio)
Actinopterygii pygo1 35
  • 56.38 (n)
  • 54.7 (a)
pygo1 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pygo 36
  • 10 (a)
OneToMany
Species with no ortholog for PYGO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYGO1 Gene

ENSEMBL:
Gene Tree for PYGO1 (if available)
TreeFam:
Gene Tree for PYGO1 (if available)

Paralogs for PYGO1 Gene

Paralogs for PYGO1 Gene

(1) SIMAP similar genes for PYGO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PYGO1: view

Variants for PYGO1 Gene

Sequence variations from dbSNP and Humsavar for PYGO1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11858624 - 55,546,387(+) TTGCA(G/T)GGTTA reference, missense
rs1926 -- 55,539,049(+) CAAAT(A/G)ACATT utr-variant-3-prime
rs545235 -- 55,586,984(+) atccc(A/G/T)gtaac intron-variant
rs667909 -- 55,569,660(+) agtac(A/G/T)gttgg intron-variant
rs479153 -- 55,584,400(+) GCCAC(C/T)GCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PYGO1 Gene

Variant ID Type Subtype PubMed ID
nsv833016 CNV Gain 17160897
nsv94482 CNV Loss 16902084

Variation tolerance for PYGO1 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PYGO1 Gene

HapMap Linkage Disequilibrium report
PYGO1
Human Gene Mutation Database (HGMD)
PYGO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYGO1 Gene

Disorders for PYGO1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PYGO1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute diarrhea
- elite association - COSMIC cancer census association via MalaCards
Search PYGO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PYGO1

Genetic Association Database (GAD)
PYGO1
Human Genome Epidemiology (HuGE) Navigator
PYGO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PYGO1
genes like me logo Genes that share disorders with PYGO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PYGO1 Gene

Publications for PYGO1 Gene

  1. Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. (PMID: 20403915) Frank B. … Brenner H. (Carcinogenesis 2010) 3 48 67
  2. A new nuclear component of the Wnt signalling pathway. (PMID: 11988739) Thompson B. … Bienz M. (Nat. Cell Biol. 2002) 2 3
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  4. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3

Products for PYGO1 Gene

Sources for PYGO1 Gene

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