PYGL Gene
protein-coding GIFtS: 66
GCID: GC14M051324
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|
phosphorylase, glycogen, liver(Previous names: phosphorylase, glycogen; liver )
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Aliases
for PYGL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphorylase, Glycogen, Liver1 2 | | EC 2.4.1.13 8 | | Phosphorylase, Glycogen; Liver1 | | GSD62 | | Glycogen Phosphorylase, Liver Form2 |
Export aliases for PYGL gene to outside databasesPrevious GC identifers: GC14M048693 GC14M045167 GC14M049361 GC14M050441 GC14M051371 GC14M031497 |
Summaries
for PYGL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PYGL:
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to releaseglucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to activephosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multipleallosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinctisozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemicdemands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storagedisease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion ofglycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly.Alternative splicing results in multiple transcript variants encoding different isoforms.(provided by RefSeq, Feb2011)
UniProtKB/Swiss-Prot: PYGL_HUMAN, P06737Function: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sourcesdiffer in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases sharecatalytic and structural properties
|
Genomic Views
for PYGL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PYGL gene promoter:
SREBP-1c Lmo2 C/EBPalpha SREBP-1b E47 SREBP-1a ZID Zic3 Hlf En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PYGL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PYGL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q21-q22 Ensembl cytogenetic band: 14q22.1 HGNC cytogenetic band: 14q11.2-q24.3PYGL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M051324: view genomic region
(about GC identifiers)
Start:
|
51,324,609 bp from pter |
End:
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51,411,454 bp from pter |
Size:
|
86,846 bases |
Orientation:
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minus strand |
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Proteins
for PYGL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PYGL_HUMAN, P06737 (See
protein sequence)Recommended Name: Glycogen phosphorylase, liver form Size: 847 amino acids; 97149 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A. Interacts withPPP1R3B (By similarity)
6/18 PDB 3D structures from  and Proteopedia  for PYGL (see all 18):1EM6 (3D)
1EXV (3D)
1FA9 (3D)
1FC0 (3D)
1L5Q (3D)
1L5R (3D)
Secondary accessions: A6NDQ4 B4DUB7 F5H816 O60567 O60752 O60913 Q501V9 Q641R5 Q96G82Alternative splicing: 2 isoforms: P06737-1 P06737-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PYGL: NX_P06737
Post-translational modifications:
Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P06737
4/39 DME Specific Peptides for PYGL (P06737) (see all 39)
PYGL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001157412.1 NP_002854.3
ENSEMBL proteins: ENSP00000431657 ENSP00000433040 ENSP00000216392 ENSP00000443787 Reactome Protein details: P06737
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
PYGL for ontologies About GeneDecksing
PYGL Antibody Products:
Assay Products for PYGL: |
Protein
Domains /
Families
for PYGL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PYGL for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P06737ProtoNet protein and cluster: P06737 1 Blocks protein family: IPB000811 Glycosyl transferase
UniProtKB/Swiss-Prot: PYGL_HUMAN, P06737Similarity: Belongs to the glycogen phosphorylase family |
Function
for PYGL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PYGL_HUMAN, P06737Function: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sourcesdiffer in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases sharecatalytic and structural propertiesCatalytic activity: (1,4-alpha-D-glucosyl)(n) + phosphate = (1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphateEnzyme regulation: Activity of phosphorylase is controlled both by allosteric means (through the noncovalent binding ofmetabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, andglucose-6-phosphate allosterically inhibit, phosphorylase B Genatlas biochemistry entry for PYGL:phosphorylase,glycogen catabolism,liver
Enzyme Number (IUBMB): EC 2.4.1.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PYGL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PYGL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PYGL (NM_002863) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PYGL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PYGL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PYGL |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
PYGL for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PYGL:
|
Pathways & Interactions
for PYGL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Galactose metabolism | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Glycogen breakdown (glycogenolysis) | | | 4 | Glucose metabolism | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for PYGL
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PYGL
2  GeneGo (Thomson Reuters) Pathways for PYGL
1  BioSystems Pathway for PYGL
4 
Reactome Pathways for PYGL
2 
Kegg Pathways (Kegg details for PYGL):
PYGL for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PYGL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/197 Interacting proteins for PYGL (P067372, 3 ENSP000002163924) via UniProtKB, MINT, STRING, and/or I2D (see all 197)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
PYGL for ontologies About GeneDecksing
|
Drugs & Compounds
for PYGL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PYGL for compounds About GeneDecksing
 Browse Tocris compounds for PYGL
10 HMDB Compounds for PYGL About this table
10/13 DrugBank Compounds for PYGL (see all 13) About this table
3 Novoseek chemical compound relationships for PYGL gene About this table
Search CenterWatch for drugs/clinical trials and news about PYGL
|
Transcripts
for PYGL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PYGL gene (2 alternative transcripts): NM_001163940.1 NM_002863.4 Unigene Cluster for PYGL: Phosphorylase, glycogen, liver Hs.282417 [show with all ESTs]Unigene Representative Sequence: BC1107918 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000532462 ENST00000531889(uc010anz.1) ENST00000216392(uc001wyu.3)
ENST00000532107 ENST00000528757 ENST00000553872 ENST00000530336(uc001wyw.4)
ENST00000544180(uc010tqq.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PYGL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PYGL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PYGL (NM_002863) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PYGL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PYGL |
Additional cDNA sequence: AF046785.1 AF066858.1 AK225904.1 AK300580.1 AK309333.1 AK313206.1 AY429567.1 BC009895.2 BC065011.1 BC082229.1 BC095850.1 BC110791.1 M14636.1 M36807.1 Y15233.1 12 DOTS entries: DT.456239 DT.40114214 DT.92437493 DT.97785611 DT.75157031 DT.91659753 DT.95172272 DT.100654951 DT.100717387 DT.100841531 DT.107816 DT.92437495 24/244 AceView cDNA sequences (see all 244): BM788535 CR593967 BU680183 BM678467 CR600182 AI697369 CR623284 BX097093 CB161603 W78842 BM467793 BQ936037 BU507725 BF509899 BG765136 CA441978 BP337901 CA406405 BQ935836 BM476749 BM013830 BU164642 BG252323 BM835766
GeneLoc Exon Structure
|
Expression
for PYGL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PYGL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCCAAAGG
About this image
See PYGL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PYGL
SOURCE GeneReport for Unigene cluster: Hs.282417
SABiosciences Expression via Pathway-Focused PCR Arrays including PYGL:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PYGL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PYGL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PYGL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PYGL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PYGL |
Orthologs
for PYGL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for PYGL gene from 7/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PYGL1 |
phosphorylase, glycogen, liver |
79.68(n)
87.5(a) |
|
378909 NM_204392.1 NP_989723.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
pygl6 |
phosphorylase, glycogen; liver (Hers disease, glyc... |
62(a) |
1 ↔ 1 |
13(37248655-37264905) |
fruit fly
(Drosophila melanogaster) |
Insecta |
GlyP3 |
carbohydrate metabolism phosphorylase |
72(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
T22F3.36 |
Phosphorylase |
64(a) |
1 → many |
V(3579044-3585042) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G293201 |
glycosyl transferase, family 35 protein |
54.82(n)
48.56(a) |
|
822590 NM_113857.3 NP_189578.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.112162 |
Oryza sativa alpha 1,4-glucan phosphorylase L isozyme mRNA, partial cds less |
75.57(n) |
|
AF327055.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
glgP6malP6 |
maltodextrin phosphorylase |
49(a)43(a) |
possible orthologpossible ortholog |
Chromosome(3562157-3564604) Chromosome(3548102-3550495) |
ENSEMBL Gene Tree for PYGL (if available)
TreeFam Gene Tree for PYGL (if available) |
Paralogs
for PYGL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PYGL gene
- PYGM2 PYGB2
2 SIMAP similar genes for PYGL using alignment to 4 protein entries: PYGL_HUMAN (see all proteins):PYGB PYGM
PYGL for paralogs About GeneDecksing
|
Genomic Variants
for PYGL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PYGL (51324609 - 51411454 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for PYGL
1 CNV: 7037
3 Indels: 40043 43140 61386
Human Gene Mutation Database (HGMD): PYGL
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for PYGL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PYGL for disorders About GeneDecksing
OMIM gene information: 613741
OMIM disorders: --
UniProtKB/Swiss-Prot: PYGL_HUMAN, P06737
Defects in PYGL are the cause of glycogen storage disease type 6 (GSD6) [MIM:232700]. A metabolic disordercharacterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heartand skeletal muscle are not affected
9  diseases for PYGL: About MalaCardsglycogen storage disease hypoglycemia glycogen storage disease vi metabolic disorders
hyperinsulinism hyperglycemia pneumonia tuberculosis
mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for PYGL:Glycogen storage disease 2 Novoseek disease relationships for PYGL gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glycogen storage disease type vi |
95 |
3 |
8275705 (1), 9536091 (1) |
| hepatomegaly |
49.1 |
1 |
15223230 (1) |
GeneTests: PYGL
Glycogen Storage Disease Type VI
Genetic Association Database (GAD): PYGL
Human Genome Epidemiology (HuGE) Navigator: PYGL (3 documents)
Export disorders for PYGL gene to outside databases
|
Publications
for PYGL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PYGL gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with PYGL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage. (PubMed id 2877458)1, 2, 3 Newgard C.B.... Fletterick R.J. (1986)
- Intermittent and recurrent hepatomegaly due to glycogen storage in a patient with type 1 diabetes: genetic analysis of the liver glycogen phosphorylase gene (PYGL). (PubMed id 15223230)1, 4, 9 Tomihira M....Nunoi K. (2004)
- Identification of a mutation in liver glycogen phosphorylase in glycogen storage disease type VI. (PubMed id 9536091)1, 2, 9 Chang S.... Biesecker L.G. (1998)
- High frequency of missense mutations in glycogen storage disease type VI. (PubMed id 17705025)1, 7, 9 Beauchamp N.J....Sharrard M.J. (2007)
- Human liver glycogen phosphorylase inhibitors bind at a new allosteric site. (PubMed id 10980448)1, 2, 9 Rath V.L.... Hoover D.J. (2000)
- Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core. (PubMed id 10949035)1, 2, 9 Rath V.L.... Pandit J. (2000)
- Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. (PubMed id 12204691)1, 2, 9 Ekstrom J.L.... Rath V.L. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mutations in the liver glycogen phosphorylase gene 'PYGL' underlying glycogenosis type VI. (PubMed id 9529348)1, 2 Burwinkel B....Kilimann M.W. (1998)
- McArdle's & Hers' diseases: glycogen phosphorylase transcriptional expression in human tissues. (PubMed id 3509980)1, 2 Gorin F.A.... Kurnit D.M. (1987)
|
External Searches for PYGL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PYGL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PYGL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PYGL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PYGL | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PYGL |
|
| | |
About This Section
| Patent Information for PYGL gene:
Search GeneIP for patents involving PYGL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PYGL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PYGL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PYGL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PYGL | | | OriGene Protein Over-expression Lysate for PYGL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PYGL | | OriGene 3'-UTR Clone for PYGL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PYGL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PYGL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PYGL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PYGL | | OriGene Custom Protein Services for PYGL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PYGL | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PYGL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PYGL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PYGL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PYGL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PYGL |
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| | | | Search Tocris compounds for PYGL |
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 | | | PYGL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PYGL |
|  |  |  | | | | Search ThermoFisher Antibodies for PYGL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PYGL |
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