Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PYDC1 Gene

Aliases for PYDC1 Gene

  • PYD (Pyrin Domain) Containing 1 2 3
  • Pyrin-Only Protein 1 3 4
  • PAAD-Only Protein 1 3 4
  • Cellular POP1 3 4
  • CPOP1 3 4
  • POP1 3 4
  • ASC2 3 4
  • PYC1 3 4
  • Pyrin Domain Containing 1 2
  • ASCI 4

External Ids for PYDC1 Gene

Previous GeneCards Identifiers for PYDC1 Gene

  • GC16M031135
  • GC16M028788

Summaries for PYDC1 Gene

GeneCards Summary for PYDC1 Gene

PYDC1 (PYD (Pyrin Domain) Containing 1) is a Protein Coding gene. Diseases associated with PYDC1 include black piedra and peptic ulcer perforation. Among its related pathways are Gene Expression and RNA transport. An important paralog of this gene is PYCARD.

UniProtKB/Swiss-Prot for PYDC1 Gene

  • Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYDC1 Gene

Genomics for PYDC1 Gene

Regulatory Elements for PYDC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PYDC1 Gene

Chromosome:
16
Start:
31,215,962 bp from pter
End:
31,217,359 bp from pter
Size:
1,398 bases
Orientation:
Minus strand

Genomic View for PYDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PYDC1 Gene

Proteins for PYDC1 Gene

  • Protein details for PYDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXC3-PYDC1_HUMAN
    Recommended name:
    Pyrin domain-containing protein 1
    Protein Accession:
    Q8WXC3
    Secondary Accessions:
    • B2R8L4
    • Q8NFP8

    Protein attributes for PYDC1 Gene

    Size:
    89 amino acids
    Molecular mass:
    10107 Da
    Quaternary structure:
    • Interacts with PYCARD/ASC (via DAPIN domain).

    Three dimensional structures from OCA and Proteopedia for PYDC1 Gene

neXtProt entry for PYDC1 Gene

Proteomics data for PYDC1 Gene at MOPED

Post-translational modifications for PYDC1 Gene

Other Protein References for PYDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PYDC1 Gene

Domains & Families for PYDC1 Gene

Gene Families for PYDC1 Gene

Protein Domains for PYDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PYDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXC3

UniProtKB/Swiss-Prot:

PYDC1_HUMAN :
  • Contains 1 DAPIN domain.
Domain:
  • Contains 1 DAPIN domain.
genes like me logo Genes that share domains with PYDC1: view

Function for PYDC1 Gene

Molecular function for PYDC1 Gene

UniProtKB/Swiss-Prot Function:
Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

Gene Ontology (GO) - Molecular Function for PYDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12656673
genes like me logo Genes that share ontologies with PYDC1: view

Phenotypes for PYDC1 Gene

GenomeRNAi human phenotypes for PYDC1:
genes like me logo Genes that share phenotypes with PYDC1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PYDC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PYDC1 Gene

Localization for PYDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYDC1 Gene

Cytoplasm. Note=Recruited to specks formed by PYCARD within the cytoplasm. {ECO:0000269 PubMed:17178784}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PYDC1 Gene COMPARTMENTS Subcellular localization image for PYDC1 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PYDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12656673
GO:0005829 cytosol IDA 12656673
GO:0008385 IkappaB kinase complex IDA 12656673
genes like me logo Genes that share ontologies with PYDC1: view

Pathways & Interactions for PYDC1 Gene

genes like me logo Genes that share pathways with PYDC1: view

Pathways by source for PYDC1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antiviral Response in human,mouse,rat
    • Inflammasomes in human,mouse,rat

Gene Ontology (GO) - Biological Process for PYDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IDA 12656673
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IMP 24871464
GO:0032088 NOT negative regulation of NF-kappaB transcription factor activity IMP 24871464
GO:0033209 tumor necrosis factor-mediated signaling pathway IDA 12656673
GO:0045087 innate immune response IDA 12656673
genes like me logo Genes that share ontologies with PYDC1: view

No data available for SIGNOR curated interactions for PYDC1 Gene

Drugs & Compounds for PYDC1 Gene

No Compound Related Data Available

Transcripts for PYDC1 Gene

mRNA/cDNA for PYDC1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PYDC1 Gene

PYD (pyrin domain) containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PYDC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYDC1 Gene

No ASD Table

Relevant External Links for PYDC1 Gene

GeneLoc Exon Structure for
PYDC1
ECgene alternative splicing isoforms for
PYDC1

Expression for PYDC1 Gene

mRNA expression in normal human tissues for PYDC1 Gene

mRNA differential expression in normal tissues according to GTEx for PYDC1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.5), Brain - Cerebellar Hemisphere (x7.3), Brain - Cerebellum (x6.4), Skin - Not Sun Exposed (Suprapubic) (x5.9), Brain - Amygdala (x5.6), and Brain - Nucleus accumbens (basal ganglia) (x5.3).

Protein differential expression in normal tissues from HIPED for PYDC1 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PYDC1 Gene



SOURCE GeneReport for Unigene cluster for PYDC1 Gene Hs.58314

mRNA Expression by UniProt/SwissProt for PYDC1 Gene

Q8WXC3-PYDC1_HUMAN
Tissue specificity: Predominantly expressed in monocytes, macrophages and granulocytes.
genes like me logo Genes that share expression patterns with PYDC1: view

Protein tissue co-expression partners for PYDC1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PYDC1 Gene

Orthologs for PYDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PYDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PYDC1 35
  • 98.88 (n)
  • 100 (a)
PYDC1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 17 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pycard 36
  • 12 (a)
OneToMany
Species with no ortholog for PYDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYDC1 Gene

ENSEMBL:
Gene Tree for PYDC1 (if available)
TreeFam:
Gene Tree for PYDC1 (if available)

Paralogs for PYDC1 Gene

Paralogs for PYDC1 Gene

(3) SIMAP similar genes for PYDC1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PYDC1: view

Variants for PYDC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PYDC1 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
dgv2672n71 CNV Loss 21882294
nsv905744 CNV Loss 21882294
nsv905745 CNV Loss 21882294
nsv905746 CNV Loss 21882294

Variation tolerance for PYDC1 Gene

Residual Variation Intolerance Score: 46.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PYDC1 Gene

HapMap Linkage Disequilibrium report
PYDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PYDC1 Gene

Disorders for PYDC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PYDC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
black piedra
  • piedra
peptic ulcer perforation
  • acute peptic ulcer with perforation
- elite association
Search PYDC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PYDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PYDC1
genes like me logo Genes that share disorders with PYDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PYDC1 Gene

Publications for PYDC1 Gene

  1. Personalized medicine in psoriasis: developing a genomic classifier to predict histological response to Alefacept. (PMID: 20152045) SuA!rez-FariA+as M. … Lowes M.A. (BMC Dermatol. 2010) 23 67
  2. Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization. (PMID: 19223583) Faustin B. … Reed J.C. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  3. Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions. (PMID: 17339483) Bedoya F. … Harton J.A. (J. Immunol. 2007) 23 67
  4. Structure and dynamics of ASC2, a pyrin domain-only protein that regulates inflammatory signaling. (PMID: 16905547) Natarajan A. … Hill J.M. (J. Biol. Chem. 2006) 2 67
  5. PYPAF1: a PYRIN-containing APAF1-like protein that assembles with ASC and activates NF-kB. (PMID: 11786556) Manji G.A. … Bertin J. (J. Biol. Chem. 2002) 2 67

Products for PYDC1 Gene

Sources for PYDC1 Gene

Back to Top

Content