Aliases for PYCRL Gene
External Ids for PYCRL Gene
Previous GeneCards Identifiers for PYCRL Gene
This gene encodes a protein that belongs to the pyrroline-5-carboxylate reductase family of enzymes. Members of this family catalyze the final step in proline biosynthesis, converting pyrroline-5-carboxylate to proline. Glutamate and ornithine are precursors in the synthesis of proline. The protein encoded by this gene is a cytoplasmic enzyme involved in the biosynthesis of proline from ornithine. [provided by RefSeq, Aug 2016]
GeneCards Summary for PYCRL Gene
PYCRL (Pyrroline-5-Carboxylate Reductase-Like) is a Protein Coding gene. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include identical protein binding and pyrroline-5-carboxylate reductase activity. An important paralog of this gene is MIR6741.
UniProtKB/Swiss-Prot for PYCRL Gene
Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.