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Aliases for PYCRL Gene

Aliases for PYCRL Gene

  • Pyrroline-5-Carboxylate Reductase-Like 2 3 5
  • P5C Reductase 3 3 4
  • EC 1.5.1.2 4 61
  • P5CR 3 3 4
  • Pyrroline-5-Carboxylate Reductase-Like Protein 4
  • Pyrroline-5-Carboxylate Reductase 3 3
  • PYCR3 3

External Ids for PYCRL Gene

Previous GeneCards Identifiers for PYCRL Gene

  • GC08M144792
  • GC08M144757
  • GC08M144686
  • GC08M139937

Summaries for PYCRL Gene

Entrez Gene Summary for PYCRL Gene

  • This gene encodes a protein that belongs to the pyrroline-5-carboxylate reductase family of enzymes. Members of this family catalyze the final step in proline biosynthesis, converting pyrroline-5-carboxylate to proline. Glutamate and ornithine are precursors in the synthesis of proline. The protein encoded by this gene is a cytoplasmic enzyme involved in the biosynthesis of proline from ornithine. [provided by RefSeq, Aug 2016]

GeneCards Summary for PYCRL Gene

PYCRL (Pyrroline-5-Carboxylate Reductase-Like) is a Protein Coding gene. Among its related pathways are Carbon metabolism and Metabolism. GO annotations related to this gene include identical protein binding and pyrroline-5-carboxylate reductase activity. An important paralog of this gene is PYCR1.

UniProtKB/Swiss-Prot for PYCRL Gene

  • Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYCRL Gene

Genomics for PYCRL Gene

Regulatory Elements for PYCRL Gene

Enhancers for PYCRL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PYCRL on UCSC Golden Path with GeneCards custom track

Promoters for PYCRL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PYCRL Gene

Chromosome:
8
Start:
143,603,913 bp from pter
End:
143,609,773 bp from pter
Size:
5,861 bases
Orientation:
Minus strand

Genomic View for PYCRL Gene

Genes around PYCRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYCRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYCRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYCRL Gene

Proteins for PYCRL Gene

  • Protein details for PYCRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H96-P5CR3_HUMAN
    Recommended name:
    Pyrroline-5-carboxylate reductase 3
    Protein Accession:
    Q53H96
    Secondary Accessions:
    • B3KMB5
    • B4DVT6
    • H0Y6C3
    • Q8N3N9
    • Q96HX4
    • Q9H896

    Protein attributes for PYCRL Gene

    Size:
    274 amino acids
    Molecular mass:
    28663 Da
    Quaternary structure:
    • Homodecamer; composed of 5 homodimers.
    SequenceCaution:
    • Sequence=BAD96405.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD96405.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for PYCRL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PYCRL Gene

Selected DME Specific Peptides for PYCRL Gene

Post-translational modifications for PYCRL Gene

  • Ubiquitination at Lys 218
  • Modification sites at PhosphoSitePlus

Other Protein References for PYCRL Gene

Domains & Families for PYCRL Gene

Suggested Antigen Peptide Sequences for PYCRL Gene

Graphical View of Domain Structure for InterPro Entry

Q53H96

UniProtKB/Swiss-Prot:

P5CR3_HUMAN :
  • Belongs to the pyrroline-5-carboxylate reductase family.
Family:
  • Belongs to the pyrroline-5-carboxylate reductase family.
genes like me logo Genes that share domains with PYCRL: view

No data available for Gene Families for PYCRL Gene

Function for PYCRL Gene

Molecular function for PYCRL Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.42 mM for NADH {ECO:0000269 PubMed:23024808}; KM=0.37 mM for NADPH {ECO:0000269 PubMed:23024808}; KM=4.64 mM for pyrroline-5-carboxylate (in the presence of NADH) {ECO:0000269 PubMed:23024808}; KM=0.38 mM for pyrroline-5-carboxylate (in the presence of NADPH) {ECO:0000269 PubMed:23024808}; Note=kcat is 197 sec(-1) for the NADH-dependent reduction reduction of pyrroline-5-carboxylate. kcat is 35 sec(-1) for the NADPH-dependent reduction of pyrroline-5-carboxylate. {ECO:0000269 PubMed:23024808};
UniProtKB/Swiss-Prot CatalyticActivity:
L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
UniProtKB/Swiss-Prot EnzymeRegulation:
Not inhibited by proline.
UniProtKB/Swiss-Prot Function:
Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.

Enzyme Numbers (IUBMB) for PYCRL Gene

Gene Ontology (GO) - Molecular Function for PYCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004735 pyrroline-5-carboxylate reductase activity IDA 23024808
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with PYCRL: view
genes like me logo Genes that share phenotypes with PYCRL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PYCRL Gene

Localization for PYCRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYCRL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PYCRL Gene COMPARTMENTS Subcellular localization image for PYCRL gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for PYCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PYCRL: view

Pathways & Interactions for PYCRL Gene

genes like me logo Genes that share pathways with PYCRL: view

UniProtKB/Swiss-Prot Q53H96-P5CR3_HUMAN

  • Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.

Gene Ontology (GO) - Biological Process for PYCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008652 cellular amino acid biosynthetic process TAS --
GO:0055114 oxidation-reduction process IEA --
GO:0055129 L-proline biosynthetic process IEA --
genes like me logo Genes that share ontologies with PYCRL: view

No data available for SIGNOR curated interactions for PYCRL Gene

Drugs & Compounds for PYCRL Gene

(4) Drugs for PYCRL Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0
hydroxyproline Approved, Experimental Pharma 0
NAD Pharma Full agonist, Agonist 0
NADH Nutra 0

(5) Additional Compounds for PYCRL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Pyrroline-5-carboxylic acid
  • (S)-1-pyrroline-5-carboxylate
  • 1-Pyrroline-5-carboxylate
  • 1-Pyrroline-5-carboxylic acid
  • 3,4-Dihydro-2h-pyrrole-2-carboxylate
  • 3,4-Dihydro-2h-pyrrole-2-carboxylic acid
2906-39-0
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Pyrroline hydroxycarboxylic acid
  • 3-Hydroxy-L-1-pyrroline-5-carboxylate
  • L-1-Pyrroline 3-hydroxy-5-carboxylate
  • L-1-Pyrroline-3-hydroxy-5-carboxylate
  • L-Delta1-pyrroline 3-hydroxy-5-carboxylate
  • Pyrroline-hydroxy-carboxylate
22573-88-2
genes like me logo Genes that share compounds with PYCRL: view

Transcripts for PYCRL Gene

Unigene Clusters for PYCRL Gene

Pyrroline-5-carboxylate reductase-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYCRL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: -
SP2:
SP3: -

Relevant External Links for PYCRL Gene

GeneLoc Exon Structure for
PYCRL
ECgene alternative splicing isoforms for
PYCRL

Expression for PYCRL Gene

mRNA expression in normal human tissues for PYCRL Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PYCRL Gene



Protein tissue co-expression partners for PYCRL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PYCRL Gene:

PYCRL

SOURCE GeneReport for Unigene cluster for PYCRL Gene:

Hs.165186
genes like me logo Genes that share expression patterns with PYCRL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PYCRL Gene

Orthologs for PYCRL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PYCRL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PYCRL 34
  • 82.66 (n)
  • 82.05 (a)
PYCRL 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PYCRL 34
  • 85.38 (n)
  • 86.67 (a)
PYCRL 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pycrl 34
  • 80.17 (n)
  • 82.12 (a)
Pycrl 16
Pycrl 35
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PYCRL 34
  • 99.77 (n)
  • 100 (a)
PYCRL 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pycrl 34
  • 80.66 (n)
  • 82.85 (a)
oppossum
(Monodelphis domestica)
Mammalia PYCRL 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PYCRL 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves PYCRL 34
  • 67.05 (n)
  • 65.27 (a)
PYCRL 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PYCRL 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pycrl 34
  • 64.84 (n)
  • 62.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16788 34
zebrafish
(Danio rerio)
Actinopterygii pycrl 34
  • 60.88 (n)
  • 55.85 (a)
pycrl 35
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005009 34
  • 51.14 (n)
  • 43.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5840 34
  • 51.14 (n)
  • 44.7 (a)
P5cr 35
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M153.1 34
  • 50.19 (n)
  • 46.42 (a)
F55G1.9 35
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRO3 35
  • 30 (a)
OneToMany
PRO3 37
thale cress
(Arabidopsis thaliana)
eudicotyledons P5CR 34
  • 45.12 (n)
  • 40.3 (a)
rice
(Oryza sativa)
Liliopsida Os01g0948400 34
  • 46.23 (n)
  • 37.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
ManyToMany
Species where no ortholog for PYCRL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PYCRL Gene

ENSEMBL:
Gene Tree for PYCRL (if available)
TreeFam:
Gene Tree for PYCRL (if available)

Paralogs for PYCRL Gene

Paralogs for PYCRL Gene

(5) SIMAP similar genes for PYCRL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PYCRL: view

Variants for PYCRL Gene

Sequence variations from dbSNP and Humsavar for PYCRL Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs11549789 - 143,607,119(-) TTGCC(A/G)GACCA reference, missense
rs2242089 - 143,606,976(-) CTGGG(A/G)TGTCT reference, missense
rs2242090 - 143,606,566(-) ACCAA(A/C/G)CTCCT reference, missense
rs1076981 -- 143,609,795(+) CATTG(A/G)CTGAG upstream-variant-2KB
rs2005166 -- 143,603,935(+) tgtca(C/T)ccagg utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PYCRL Gene

Variant ID Type Subtype PubMed ID
dgv12410n54 CNV loss 21841781
dgv12418n54 CNV loss 21841781
dgv12419n54 CNV loss 21841781
dgv271n111 CNV deletion 26073780
dgv7336n100 CNV gain 25217958
esv3397304 CNV duplication 20981092
nsv1161809 CNV deletion 26073780
nsv1161810 CNV deletion 26073780
nsv466004 CNV loss 19166990
nsv470247 CNV loss 18288195
nsv516210 CNV loss 19592680
nsv612774 CNV loss 21841781
nsv612777 CNV gain 21841781
nsv612793 CNV loss 21841781
nsv612813 CNV loss 21841781
nsv612822 CNV gain 21841781
nsv612849 CNV loss 21841781
nsv6439 CNV deletion 18451855
nsv831488 CNV loss 17160897
nsv950013 CNV deletion 24416366

Variation tolerance for PYCRL Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.97; 93.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PYCRL Gene

Human Gene Mutation Database (HGMD)
PYCRL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PYCRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYCRL Gene

Disorders for PYCRL Gene

Relevant External Links for PYCRL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PYCRL

No disorders were found for PYCRL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PYCRL Gene

Publications for PYCRL Gene

  1. Functional specialization in proline biosynthesis of melanoma. (PMID: 23024808) De Ingeniis J. … Smith J.W. (PLoS ONE 2012) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for PYCRL Gene

Sources for PYCRL Gene

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