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Aliases for PYCRL Gene

Aliases for PYCRL Gene

  • Pyrroline-5-Carboxylate Reductase-Like 2 3 5
  • Pyrroline-5-Carboxylate Reductase-Like Protein 3 4
  • P5C Reductase 3 3 4
  • EC 1.5.1.2 4 63
  • P5CR 3 3 4
  • PYCR3 3

External Ids for PYCRL Gene

Previous GeneCards Identifiers for PYCRL Gene

  • GC08M144792
  • GC08M144757
  • GC08M144686
  • GC08M139937

Summaries for PYCRL Gene

GeneCards Summary for PYCRL Gene

PYCRL (Pyrroline-5-Carboxylate Reductase-Like) is a Protein Coding gene. Among its related pathways are Amino acid synthesis and interconversion (transamination) and Metabolism. GO annotations related to this gene include identical protein binding and pyrroline-5-carboxylate reductase activity. An important paralog of this gene is PYCR2.

UniProtKB/Swiss-Prot for PYCRL Gene

  • Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYCRL Gene

Genomics for PYCRL Gene

Regulatory Elements for PYCRL Gene

Enhancers for PYCRL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PYCRL on UCSC Golden Path with GeneCards custom track

Promoters for PYCRL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PYCRL on UCSC Golden Path with GeneCards custom track

Genomic Location for PYCRL Gene

Chromosome:
8
Start:
143,603,913 bp from pter
End:
143,609,773 bp from pter
Size:
5,861 bases
Orientation:
Minus strand

Genomic View for PYCRL Gene

Genes around PYCRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYCRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYCRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYCRL Gene

Proteins for PYCRL Gene

  • Protein details for PYCRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H96-P5CR3_HUMAN
    Recommended name:
    Pyrroline-5-carboxylate reductase 3
    Protein Accession:
    Q53H96
    Secondary Accessions:
    • B3KMB5
    • B4DVT6
    • H0Y6C3
    • Q8N3N9
    • Q96HX4
    • Q9H896

    Protein attributes for PYCRL Gene

    Size:
    274 amino acids
    Molecular mass:
    28663 Da
    Quaternary structure:
    • Homodecamer; composed of 5 homodimers.
    SequenceCaution:
    • Sequence=BAD96405.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD96405.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for PYCRL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PYCRL Gene

Proteomics data for PYCRL Gene at MOPED

Selected DME Specific Peptides for PYCRL Gene

Post-translational modifications for PYCRL Gene

  • Ubiquitination at Lys 218
  • Modification sites at PhosphoSitePlus

Other Protein References for PYCRL Gene

Domains & Families for PYCRL Gene

Suggested Antigen Peptide Sequences for PYCRL Gene

Graphical View of Domain Structure for InterPro Entry

Q53H96

UniProtKB/Swiss-Prot:

P5CR3_HUMAN :
  • Belongs to the pyrroline-5-carboxylate reductase family.
Family:
  • Belongs to the pyrroline-5-carboxylate reductase family.
genes like me logo Genes that share domains with PYCRL: view

No data available for Gene Families for PYCRL Gene

Function for PYCRL Gene

Molecular function for PYCRL Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.42 mM for NADH {ECO:0000269 PubMed:23024808}; KM=0.37 mM for NADPH {ECO:0000269 PubMed:23024808}; KM=4.64 mM for pyrroline-5-carboxylate (in the presence of NADH) {ECO:0000269 PubMed:23024808}; KM=0.38 mM for pyrroline-5-carboxylate (in the presence of NADPH) {ECO:0000269 PubMed:23024808}; Note=kcat is 197 sec(-1) for the NADH-dependent reduction reduction of pyrroline-5-carboxylate. kcat is 35 sec(-1) for the NADPH-dependent reduction of pyrroline-5-carboxylate. {ECO:0000269 PubMed:23024808};
UniProtKB/Swiss-Prot CatalyticActivity:
L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
UniProtKB/Swiss-Prot EnzymeRegulation:
Not inhibited by proline.
UniProtKB/Swiss-Prot Function:
Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.

Enzyme Numbers (IUBMB) for PYCRL Gene

Gene Ontology (GO) - Molecular Function for PYCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004735 pyrroline-5-carboxylate reductase activity IDA 23024808
genes like me logo Genes that share ontologies with PYCRL: view
genes like me logo Genes that share phenotypes with PYCRL: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PYCRL Gene

Localization for PYCRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYCRL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PYCRL Gene COMPARTMENTS Subcellular localization image for PYCRL gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for PYCRL Gene

Pathways & Interactions for PYCRL Gene

genes like me logo Genes that share pathways with PYCRL: view

UniProtKB/Swiss-Prot Q53H96-P5CR3_HUMAN

  • Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.

Gene Ontology (GO) - Biological Process for PYCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006561 proline biosynthetic process IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0055129 L-proline biosynthetic process IEA --
genes like me logo Genes that share ontologies with PYCRL: view

No data available for SIGNOR curated interactions for PYCRL Gene

Drugs & Compounds for PYCRL Gene

(4) Drugs for PYCRL Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0
hydroxyproline Approved, Experimental Pharma 0
NAD Pharma Full agonist, Agonist 0
NADH Nutra 0

(5) Additional Compounds for PYCRL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Pyrroline-5-carboxylic acid
  • (S)-1-pyrroline-5-carboxylate
  • 1-Pyrroline-5-carboxylate
  • 1-Pyrroline-5-carboxylic acid
  • 3,4-Dihydro-2h-pyrrole-2-carboxylate
  • 3,4-Dihydro-2h-pyrrole-2-carboxylic acid
2906-39-0
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Pyrroline hydroxycarboxylic acid
  • 3-Hydroxy-L-1-pyrroline-5-carboxylate
  • L-1-Pyrroline 3-hydroxy-5-carboxylate
  • L-1-Pyrroline-3-hydroxy-5-carboxylate
  • L-Delta1-pyrroline 3-hydroxy-5-carboxylate
  • Pyrroline-hydroxy-carboxylate
22573-88-2
genes like me logo Genes that share compounds with PYCRL: view

Transcripts for PYCRL Gene

Unigene Clusters for PYCRL Gene

Pyrroline-5-carboxylate reductase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PYCRL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: -
SP2:
SP3: -

Relevant External Links for PYCRL Gene

GeneLoc Exon Structure for
PYCRL
ECgene alternative splicing isoforms for
PYCRL

Expression for PYCRL Gene

mRNA expression in normal human tissues for PYCRL Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PYCRL Gene



SOURCE GeneReport for Unigene cluster for PYCRL Gene Hs.165186

genes like me logo Genes that share expression patterns with PYCRL: view

Protein tissue co-expression partners for PYCRL Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PYCRL Gene

Orthologs for PYCRL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PYCRL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PYCRL 35
  • 82.66 (n)
  • 82.05 (a)
PYCRL 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PYCRL 35
  • 85.38 (n)
  • 86.67 (a)
PYCRL 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pycrl 35
  • 80.17 (n)
  • 82.12 (a)
Pycrl 16
Pycrl 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PYCRL 35
  • 99.77 (n)
  • 100 (a)
PYCRL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pycrl 35
  • 80.66 (n)
  • 82.85 (a)
oppossum
(Monodelphis domestica)
Mammalia PYCRL 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PYCRL 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves PYCRL 35
  • 67.05 (n)
  • 65.27 (a)
PYCRL 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PYCRL 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pycrl 35
  • 64.84 (n)
  • 62.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16788 35
zebrafish
(Danio rerio)
Actinopterygii pycrl 35
  • 60.88 (n)
  • 55.85 (a)
pycrl 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005009 35
  • 51.14 (n)
  • 43.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5840 35
  • 51.14 (n)
  • 44.7 (a)
P5cr 36
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M153.1 35
  • 50.19 (n)
  • 46.42 (a)
F55G1.9 36
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRO3 36
  • 30 (a)
OneToMany
PRO3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons P5CR 35
  • 45.12 (n)
  • 40.3 (a)
rice
(Oryza sativa)
Liliopsida Os01g0948400 35
  • 46.23 (n)
  • 37.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
Species with no ortholog for PYCRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PYCRL Gene

ENSEMBL:
Gene Tree for PYCRL (if available)
TreeFam:
Gene Tree for PYCRL (if available)

Paralogs for PYCRL Gene

Paralogs for PYCRL Gene

(5) SIMAP similar genes for PYCRL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PYCRL: view

Variants for PYCRL Gene

Sequence variations from dbSNP and Humsavar for PYCRL Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs11549789 - 143,607,119(-) TTGCC(A/G)GACCA reference, missense
rs2242089 - 143,606,976(-) CTGGG(A/G)TGTCT reference, missense
rs2242090 - 143,606,566(-) ACCAA(A/C/G)CTCCT reference, missense
rs2085014 -- 143,610,436(-) GAGAT(C/T)GAGAC upstream-variant-2KB
rs2085015 -- 143,610,404(-) acccc(A/G)tctct upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PYCRL Gene

Variant ID Type Subtype PubMed ID
nsv470247 CNV Loss 18288195
nsv891676 CNV Loss 21882294
dgv7928n71 CNV Loss 21882294
dgv7932n71 CNV Loss 21882294
dgv7933n71 CNV Loss 21882294
dgv7934n71 CNV Loss 21882294
nsv516210 CNV Loss 19592680
dgv7935n71 CNV Loss 21882294
dgv7936n71 CNV Loss 21882294
dgv7937n71 CNV Loss 21882294
nsv891737 CNV Gain 21882294
nsv466004 CNV Loss 19166990
nsv891739 CNV Loss 21882294
nsv831488 CNV Loss 17160897
nsv6439 CNV Loss 18451855

Variation tolerance for PYCRL Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.97; 93.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PYCRL Gene

Human Gene Mutation Database (HGMD)
PYCRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYCRL Gene

Disorders for PYCRL Gene

Relevant External Links for PYCRL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PYCRL

No disorders were found for PYCRL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PYCRL Gene

Publications for PYCRL Gene

  1. Functional specialization in proline biosynthesis of melanoma. (PMID: 23024808) De Ingeniis J. … Smith J.W. (PLoS ONE 2012) 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  5. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3

Products for PYCRL Gene

Sources for PYCRL Gene

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