Aliases for PYCR2 Gene
External Ids for PYCR2 Gene
Previous GeneCards Identifiers for PYCR2 Gene
This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
GeneCards Summary for PYCR2 Gene
PYCR2 (Pyrroline-5-Carboxylate Reductase Family, Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include pyrroline-5-carboxylate reductase activity. An important paralog of this gene is ENSG00000255835.
UniProtKB/Swiss-Prot for PYCR2 Gene
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH.