Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PYCARD Gene

Aliases for PYCARD Gene

  • PYD And CARD Domain Containing 2 3 5
  • Caspase Recruitment Domain-Containing Protein 5 3 4
  • Target Of Methylation-Induced Silencing 1 3 4
  • CARD5 3 4
  • TMS1 3 4
  • ASC 3 4
  • Apoptosis-Associated Speck-Like Protein Containing A CARD 3
  • PYD And CARD Domain-Containing Protein 4
  • TMS-1 3
  • HASC 4
  • TMS 3

External Ids for PYCARD Gene

Previous GeneCards Identifiers for PYCARD Gene

  • GC16M031249
  • GC16M031120
  • GC16M028774

Summaries for PYCARD Gene

Entrez Gene Summary for PYCARD Gene

  • This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PYCARD Gene

PYCARD (PYD And CARD Domain Containing) is a Protein Coding gene. Diseases associated with PYCARD include Chronic Recurrent Multifocal Osteomyelitis and Cinca Syndrome. Among its related pathways are Immune System and Pertussis. GO annotations related to this gene include protein homodimerization activity and ion channel binding. An important paralog of this gene is PYDC1.

UniProtKB/Swiss-Prot for PYCARD Gene

  • Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. Isoform 2 may have a regulating effect on the function as inflammasome adapter. Isoform 3 seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing.

Gene Wiki entry for PYCARD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYCARD Gene

Genomics for PYCARD Gene

Regulatory Elements for PYCARD Gene

Enhancers for PYCARD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F031252 1.6 FANTOM5 Ensembl ENCODE 17.9 -50.5 -50451 2.6 ATF1 PKNOX1 ARNT ZNF493 FOS ZNF202 JUNB NCOA1 REST ZNF623 ENSG00000260267 ZNF720 ZNF747 ZNF764 ENSG00000260304 NPIPB13 PYDC1 BCL7C ZNF785 ENSG00000261474
GH16F031178 1.2 ENCODE 22.5 +22.6 22617 4.7 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MIR762HG ZNF785 ZNF720 PYCARD ZNF689 BCL7C ENSG00000260267 NDUFA3P6 PYDC1 ENSG00000261648
GH16F031242 1 Ensembl 16.4 -39.0 -38951 0.4 ATF1 PKNOX1 ARNT FOS NCOA1 MEF2D SMARCA4 MYNN PBX2 HMBOX1 PYCARD PYDC1 TRIM72 FUS PRSS8 GC16P031242 GC16P031225
GH16F031301 0.9 Ensembl ENCODE 16.4 -98.6 -98585 0.9 SRF HLF CEBPB CEBPG REST RAD21 IRF9 ZNF512 CEBPA ZMIZ1 PYCARD PYDC1 FUS STX4 STX1B SETD1A ITGAM ITGAX
GH16F031243 1.1 Ensembl ENCODE 12.3 -41.7 -41744 2.8 BCOR HDAC1 PKNOX1 ATF1 ETV1 ZMYM3 NCOR1 GATA2 EED ZSCAN29 PYDC1 PYCARD TRIM72 FUS PRSS8 ZNF764 GC16P031242 ITGAM
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PYCARD on UCSC Golden Path with GeneCards custom track

Promoters for PYCARD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000148631 850 1601 HDGF KLF1 SUZ12 HINFP SIN3A ZNF2 E2F1 ZFHX2 GLIS2 EGR1

Genomic Location for PYCARD Gene

Chromosome:
16
Start:
31,201,485 bp from pter
End:
31,203,450 bp from pter
Size:
1,966 bases
Orientation:
Minus strand

Genomic View for PYCARD Gene

Genes around PYCARD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYCARD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYCARD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYCARD Gene

Proteins for PYCARD Gene

  • Protein details for PYCARD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULZ3-ASC_HUMAN
    Recommended name:
    Apoptosis-associated speck-like protein containing a CARD
    Protein Accession:
    Q9ULZ3
    Secondary Accessions:
    • Q96D12
    • Q9BSZ5
    • Q9HBD0
    • Q9NXJ8

    Protein attributes for PYCARD Gene

    Size:
    195 amino acids
    Molecular mass:
    21627 Da
    Quaternary structure:
    • Self-associates; enforced oligomerization induces apoptosis, NF-kappa-B regulation and interleukin-1 beta secretion. Homooligomers can form disk-like particles of approximately 12 nm diameter and approximately 1 nm height. Next to isorm 1 also isoform 2 and isoform 3 may be involved in oligomerization leading to functional regulation. Component of several inflammasomes containing one pattern recognition receptor/sensor, such as NLRP1, NLRP2, NLRP3, AIM2, MEFV or NOD2, and probably NLRC4, NLRP12 or IFI16. Major component of the ASC pyroptosome, a 1-2 um supramolecular assembly (one per macrophage cell) which consists of oligomerized PYCARD dimers and CASP1. Interacts with CASP1 (precursor form); the interaction induces activation of CASP1 leading to the processing of interleukin-1 beta; PYCARD competes with RIPK2 for binding to CASP1. Interacts with NLRP3; the interaction requires the homooligomerization of NLRP3. Interacts with NLRP2, NLRC4, MEFV, CARD16, AIM2, IFI16, NOD2, DDX58, RIPK2, PYDC1, PYDC2, NLRP10, CASP8, CHUK, IKBKB and BAX.
    Miscellaneous:
    • In breast tumorigenesis, methylation-mediated silencing may affect genes and proteins that act as positive mediators of cell death.
    SequenceCaution:
    • Sequence=BAA91012.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PYCARD Gene

    Alternative splice isoforms for PYCARD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PYCARD Gene

Post-translational modifications for PYCARD Gene

Other Protein References for PYCARD Gene

No data available for DME Specific Peptides for PYCARD Gene

Domains & Families for PYCARD Gene

Protein Domains for PYCARD Gene

Suggested Antigen Peptide Sequences for PYCARD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULZ3

UniProtKB/Swiss-Prot:

ASC_HUMAN :
  • The CARD domain mediates interaction with CASP1 and NLRC4 (PubMed:14634131 and PubMed:11967258).
Domain:
  • The CARD domain mediates interaction with CASP1 and NLRC4 (PubMed:14634131 and PubMed:11967258).
  • The pyrin domain mediates homotypic interactions with pyrin domains of proteins such as of NLRP3, PYDC1, PYDC2 and AIM2.
  • Contains 1 CARD domain.
  • Contains 1 pyrin domain.
genes like me logo Genes that share domains with PYCARD: view

Function for PYCARD Gene

Molecular function for PYCARD Gene

UniProtKB/Swiss-Prot Function:
Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. Isoform 2 may have a regulating effect on the function as inflammasome adapter. Isoform 3 seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing.

Gene Ontology (GO) - Molecular Function for PYCARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 24407287
GO:0005138 interleukin-6 receptor binding IPI 24407287
GO:0005515 protein binding IPI 11786556
GO:0005523 tropomyosin binding IPI 24407287
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process NAS 12019269
genes like me logo Genes that share ontologies with PYCARD: view
genes like me logo Genes that share phenotypes with PYCARD: view

Animal Models for PYCARD Gene

MGI Knock Outs for PYCARD:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PYCARD Gene

Localization for PYCARD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYCARD Gene

Cytoplasm. Endoplasmic reticulum. Mitochondrion. Nucleus. Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures. Upon NLRP3 inflammasome activation redistributes to the perinuclear space localizing to endoplasmic reticulum and mitochondria. Localized primarily to the nucleus in resting monocytes/macrophages and rapidly redistributed to the cytoplasm upon pathogen infection. Localized to large cytoplasmic aggregate appearing as a speck containing AIM2, PYCARD, CASP8 and bacterial DNA after infection with Francisella tularensis (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PYCARD gene
Compartment Confidence
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
extracellular 4
lysosome 4

Gene Ontology (GO) - Cellular Components for PYCARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm NAS 12019269
GO:0005739 mitochondrion IEA,IDA 14730312
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with PYCARD: view

Pathways & Interactions for PYCARD Gene

genes like me logo Genes that share pathways with PYCARD: view

SIGNOR curated interactions for PYCARD Gene

Activates:

Gene Ontology (GO) - Biological Process for PYCARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001773 myeloid dendritic cell activation IMP 22732093
GO:0002218 activation of innate immune response IDA 21575908
GO:0002277 myeloid dendritic cell activation involved in immune response ISS --
GO:0002376 immune system process IEA --
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II ISS --
genes like me logo Genes that share ontologies with PYCARD: view

Drugs & Compounds for PYCARD Gene

(1) Additional Compounds for PYCARD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PYCARD: view

Transcripts for PYCARD Gene

Unigene Clusters for PYCARD Gene

PYD and CARD domain containing:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYCARD Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for PYCARD Gene

GeneLoc Exon Structure for
PYCARD
ECgene alternative splicing isoforms for
PYCARD

Expression for PYCARD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PYCARD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PYCARD Gene

This gene is overexpressed in Whole Blood (x18.2).

Protein differential expression in normal tissues from HIPED for PYCARD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PYCARD Gene



Protein tissue co-expression partners for PYCARD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PYCARD Gene:

PYCARD

SOURCE GeneReport for Unigene cluster for PYCARD Gene:

Hs.499094

mRNA Expression by UniProt/SwissProt for PYCARD Gene:

Q9ULZ3-ASC_HUMAN
Tissue specificity: Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U-937, but not in Jurkat T-cell lymphoma and Daudi Burkitts lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and MOLT-4 lymphocytic leukemia cells.
genes like me logo Genes that share expression patterns with PYCARD: view

Orthologs for PYCARD Gene

This gene was present in the common ancestor of chordates.

Orthologs for PYCARD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PYCARD 34 35
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia PYCARD 34 35
  • 81.54 (n)
dog
(Canis familiaris)
Mammalia PYCARD 34 35
  • 77.84 (n)
mouse
(Mus musculus)
Mammalia Pycard 34 16 35
  • 74.27 (n)
rat
(Rattus norvegicus)
Mammalia Pycard 34
  • 74.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491802 34
  • 58.62 (n)
zebrafish
(Danio rerio)
Actinopterygii pycard 35
  • 30 (a)
OneToMany
Species where no ortholog for PYCARD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYCARD Gene

ENSEMBL:
Gene Tree for PYCARD (if available)
TreeFam:
Gene Tree for PYCARD (if available)

Paralogs for PYCARD Gene

Paralogs for PYCARD Gene

(3) SIMAP similar genes for PYCARD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PYCARD: view

Variants for PYCARD Gene

Sequence variations from dbSNP and Humsavar for PYCARD Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111901353 -- 31,204,320(+) CTGAA(A/C)CCGTG upstream-variant-2KB
rs112701104 -- 31,204,665(+) TAAAA(-/T)TTTTA upstream-variant-2KB
rs113157066 -- 31,203,395(+) TGATT(-/A)AAAAA nc-transcript-variant, upstream-variant-2KB
rs113789888 -- 31,203,840(+) CATCT(C/G)AAAAA intron-variant, upstream-variant-2KB
rs115908198 -- 31,201,523(+) AAGAT(C/G)AGATT upstream-variant-2KB, utr-variant-3-prime

Variation tolerance for PYCARD Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PYCARD Gene

Human Gene Mutation Database (HGMD)
PYCARD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PYCARD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PYCARD Gene

Disorders for PYCARD Gene

MalaCards: The human disease database

(3) MalaCards diseases for PYCARD Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic recurrent multifocal osteomyelitis
  • chronic multifocal osteomyelitis
cinca syndrome
  • chronic infantile neurological cutaneous articular syndrome
legionellosis
  • legionella infection
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PYCARD

Genetic Association Database (GAD)
PYCARD
Human Genome Epidemiology (HuGE) Navigator
PYCARD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PYCARD
genes like me logo Genes that share disorders with PYCARD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PYCARD Gene

Publications for PYCARD Gene

  1. Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC). (PMID: 19759015) de Alba E. (J. Biol. Chem. 2009) 3 4 22 64
  2. Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions. (PMID: 17339483) Bedoya F. … Harton J.A. (J. Immunol. 2007) 3 4 22 64
  3. Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. (PMID: 16037825) Yu J.W. … Alnemri E.S. (Cell Death Differ. 2006) 3 4 22 64
  4. PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. (PMID: 15456791) Bruey J.-M. … Reed J.C. (J. Biol. Chem. 2004) 3 4 22 64
  5. ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. (PMID: 14730312) Ohtsuka T. … Lee S.W. (Nat. Cell Biol. 2004) 3 4 22 64

Products for PYCARD Gene

Sources for PYCARD Gene

Content
Loading form....