Aliases for PXYLP1 Gene
External Ids for PXYLP1 Gene
Previous HGNC Symbols for PXYLP1 Gene
Previous GeneCards Identifiers for PXYLP1 Gene
GeneCards Summary for PXYLP1 Gene
PXYLP1 (2-Phosphoxylose Phosphatase 1) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and acid phosphatase activity.
UniProtKB/Swiss-Prot for PXYLP1 Gene
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.