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Aliases for PXYLP1 Gene

Aliases for PXYLP1 Gene

  • 2-Phosphoxylose Phosphatase 1 2 3
  • Acid Phosphatase-Like Protein 2 3 4
  • Epididymis Luminal Protein 124 3 4
  • Acid Phosphatase-Like 2 2 3
  • Xylosyl Phosphatase 3 4
  • HEL124 3 4
  • ACPL2 3 4
  • XYLP 3 4
  • EC 3.1.3.2 63
  • EC 3.1.3.- 4

External Ids for PXYLP1 Gene

Previous HGNC Symbols for PXYLP1 Gene

  • ACPL2

Previous GeneCards Identifiers for PXYLP1 Gene

  • GC03P140947

Summaries for PXYLP1 Gene

GeneCards Summary for PXYLP1 Gene

PXYLP1 (2-Phosphoxylose Phosphatase 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PXYLP1 Gene

  • Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PXYLP1 Gene

Genomics for PXYLP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PXYLP1 Gene

Start:
141,228,726 bp from pter
End:
141,294,906 bp from pter
Size:
66,181 bases
Orientation:
Plus strand

Genomic View for PXYLP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PXYLP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXYLP1 Gene

No data available for Regulatory Elements for PXYLP1 Gene

Proteins for PXYLP1 Gene

  • Protein details for PXYLP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE99-PXYP1_HUMAN
    Recommended name:
    2-phosphoxylose phosphatase 1
    Protein Accession:
    Q8TE99
    Secondary Accessions:
    • D3DNF5
    • Q49AJ2
    • W0TR04

    Protein attributes for PXYLP1 Gene

    Size:
    480 amino acids
    Molecular mass:
    55240 Da
    Quaternary structure:
    • Interacts with B3GAT3; the interaction increases the 2-phosphoxylose phosphatase activity of PXYLP1 during completion of linkage region formation in a B3GAT3-mediated manner.

    Alternative splice isoforms for PXYLP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PXYLP1 Gene

Proteomics data for PXYLP1 Gene at MOPED

Selected DME Specific Peptides for PXYLP1 Gene

Post-translational modifications for PXYLP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PXYLP1 Gene

Protein Domains for PXYLP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TE99

UniProtKB/Swiss-Prot:

PXYP1_HUMAN :
  • Q8TE99
Family:
  • Belongs to the histidine acid phosphatase family.
genes like me logo Genes that share domains with PXYLP1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for PXYLP1 Gene

Function for PXYLP1 Gene

Molecular function for PXYLP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 5.8. {ECO:0000269 PubMed:24425863};
UniProtKB/Swiss-Prot Function:
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.

Enzyme Numbers (IUBMB) for PXYLP1 Gene

Gene Ontology (GO) - Molecular Function for PXYLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IEA --
GO:0005515 protein binding IPI 24425863
GO:0016791 phosphatase activity IDA 24425863
genes like me logo Genes that share ontologies with PXYLP1: view
genes like me logo Genes that share phenotypes with PXYLP1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PXYLP1 Gene

Localization for PXYLP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXYLP1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein. Note=Colocalizes to Golgi apparatus in a B3GAT3-dependent manner. {ECO:0000269 PubMed:24425863}.

Gene Ontology (GO) - Cellular Components for PXYLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region --
GO:0005794 Golgi apparatus IDA 24425863
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PXYLP1: view

No data available for Subcellular locations from COMPARTMENTS for PXYLP1 Gene

Pathways for PXYLP1 Gene

SuperPathways for PXYLP1 Gene

No Data Available

Interacting Proteins for PXYLP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000286353%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000286353 for PXYLP1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for PXYLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process IDA 24425863
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process IMP 24425863
GO:0016311 dephosphorylation IEA --
GO:0050650 chondroitin sulfate proteoglycan biosynthetic process IMP 24425863
genes like me logo Genes that share ontologies with PXYLP1: view

No data available for Pathways by source for PXYLP1 Gene

Transcripts for PXYLP1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PXYLP1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PXYLP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - - - -
SP3:
SP4: -
SP5: - - -

Relevant External Links for PXYLP1 Gene

GeneLoc Exon Structure for
PXYLP1
ECgene alternative splicing isoforms for
PXYLP1

Expression for PXYLP1 Gene

mRNA expression in normal human tissues for PXYLP1 Gene

Protein differential expression in normal tissues for PXYLP1 Gene

This gene is overexpressed in Oral epithelium (54.5) and Heart (13.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PXYLP1 Gene

mRNA Expression by UniProt/SwissProt for PXYLP1 Gene

Q8TE99-PXYP1_HUMAN
Tissue specificity: Widely expressed. Strongly expressed in spleen, fetal liver, moderately in placenta, pancreas, kidney, thymus and colon.
genes like me logo Genes that share expressions with PXYLP1: view

Expression partners for PXYLP1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PXYLP1 Gene

Orthologs for PXYLP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PXYLP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACPL2 35
  • 82.99 (n)
  • 84.28 (a)
ACPL2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACPL2 35
  • 89.61 (n)
  • 93.94 (a)
ACPL2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acpl2 35
  • 84.74 (n)
  • 89.59 (a)
Acpl2 16
Acpl2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACPL2 35
  • 99.58 (n)
  • 99.17 (a)
ACPL2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acpl2 35
  • 84.09 (n)
  • 89.59 (a)
oppossum
(Monodelphis domestica)
Mammalia ACPL2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves ACPL2 35
  • 73.09 (n)
  • 74.62 (a)
ACPL2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACPL2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acpl2 35
  • 68.48 (n)
  • 68.04 (a)
zebrafish
(Danio rerio)
Actinopterygii acpl2 35
  • 59.14 (n)
  • 54.17 (a)
acpl2 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010170 35
  • 45.38 (n)
  • 30.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15385 35
  • 44.39 (n)
  • 30.87 (a)
CG15385 36
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK792.1 35
  • 40.84 (n)
  • 29.4 (a)
ZK792.1 36
  • 20 (a)
OneToMany
ZK809.9 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1630 36
  • 28 (a)
OneToOne
Species with no ortholog for PXYLP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PXYLP1 Gene

ENSEMBL:
Gene Tree for PXYLP1 (if available)
TreeFam:
Gene Tree for PXYLP1 (if available)

Paralogs for PXYLP1 Gene

No data available for Paralogs for PXYLP1 Gene

Variants for PXYLP1 Gene

Sequence variations from dbSNP and Humsavar for PXYLP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8800 -- 141,294,426(+) ATTAG(A/G)TAGTT utr-variant-3-prime
rs870400 -- 141,252,478(+) GAGCG(A/G)GAGCA intron-variant
rs899345 -- 141,272,025(-) GCAAG(C/G)TCCTT intron-variant
rs899346 -- 141,271,942(-) ACTTC(C/G)TTCTG intron-variant
rs899349 -- 141,252,334(-) TTTAT(A/G)AGTTA intron-variant

Relevant External Links for PXYLP1 Gene

HapMap Linkage Disequilibrium report
PXYLP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PXYLP1 Gene

Disorders for PXYLP1 Gene

No disorders were found for PXYLP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PXYLP1 Gene

Publications for PXYLP1 Gene

  1. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. (PMID: 24425863) Koike T. … Kitagawa H. (J. Biol. Chem. 2014) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for PXYLP1 Gene

Sources for PXYLP1 Gene

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