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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PXN Gene

protein-coding   GIFtS: 69
GCID: GC12M120648

Paxillin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
paxillin1 2

External Ids:    HGNC: 97181   Entrez Gene: 58292   Ensembl: ENSG000000891597   OMIM: 6025055   UniProtKB: P490233   

Export aliases for PXN gene to outside databases

Previous GC identifers: GC12M119521 GC12M120174 GC12M120431 GC12M119060 GC12M119110 GC12M117656


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PXN Gene:
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the
extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have
been described for this gene. These isoforms exhibit different expression pattern, and have different
biochemical, as well as physiological properties (PMID:9054445). (provided by RefSeq, Aug 2011)

GeneCards Summary for PXN Gene: 
PXN (paxillin) is a protein-coding gene. Diseases associated with PXN include clostridium difficile, and cerebral cavernous malformation, and among its related super-pathways are Integrin-mediated cell adhesion and Regulation of actin cytoskeleton. GO annotations related to this gene include beta-catenin binding and protein kinase binding. An important paralog of this gene is ABLIM3.

UniProtKB/Swiss-Prot: PAXI_HUMAN, P49023
Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the
extracellular matrix (focal adhesion)

Gene Wiki entry for PXN (Paxillin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PXN gene promoter:
         E2F-1   E2F   AP-1   ATF-2   STAT3   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPXN promoter sequence
   Search SABiosciences Chromatin IP Primers for PXN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PXN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24

PXN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PXN gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120648:  view genomic region     (about GC identifiers)

Start:
120,648,250 bp from pter      End:
120,703,574 bp from pter
Size:
55,325 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAXI_HUMAN, P49023 (See protein sequence)
Recommended Name: Paxillin  
Size: 591 amino acids; 64505 Da
Subunit: Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the
SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but
only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1. Component of cytoplasmic complexes,
which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2.
Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction
is prolactin-dependent. Interacts with PTK6. Interacts with SORBS1, PARVA and PARVB
Subcellular location: Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex (By
similarity). Note=Colocalizes with integrins at the cell periphery (By similarity)
6/18 PDB 3D structures from and Proteopedia for PXN (see all 18):
1KKY (3D)        1KL0 (3D)        1OW6 (3D)        1OW7 (3D)        1OW8 (3D)        2K2R (3D)    
Secondary accessions: B2RAI3 B7ZMB4 O14970 O14971 O60360 Q5HYA4
Alternative splicing: 4 isoforms:  P49023-1   P49023-2   P49023-3   P49023-4   

Explore the universe of human proteins at neXtProt for PXN: NX_P49023

Explore proteomics data for PXN at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell
    adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
    Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA)
    during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the
    activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49023

  • PXN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PXN Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001074324.1  NP_001230685.1  NP_002850.2  NP_079433.3  

    ENSEMBL proteins: 
     ENSP00000395536   ENSP00000228307   ENSP00000391283   ENSP00000443887   ENSP00000449198  
     ENSP00000446893   ENSP00000443745   ENSP00000447180   ENSP00000446607   ENSP00000446650  
     ENSP00000267257   ENSP00000380643  
    Reactome Protein details: P49023
    Human Recombinant Protein Products for PXN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PXN
    OriGene Protein Over-expression Lysate for PXN
    OriGene MassSpec for PXN 
    OriGene Custom Protein Services for PXN
    GenScript Custom Purified and Recombinant Proteins Services for PXN
    Novus Biologicals PXN Proteins
    Novus Biologicals PXN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton ----
    GO:0005875microtubule associated complex TAS10840040
    GO:0005886plasma membrane TAS--
    GO:0005925focal adhesion IDA12686598
    GO:0005938cell cortex IEA--

    PXN for ontologies           About GeneDecksing



    PXN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PXN
    R&D Systems Antibodies for PXN (Paxillin)
    Cell Signaling Technology (CST) Antibodies for PXN 
    OriGene Antibodies for PXN
    OriGene Custom Antibody Services for PXN
    GenScript Custom Superior Antibodies Services for PXN
    Novus Biologicals PXN Antibodies
    Abcam antibodies for PXN
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for PXN
    LSBio Antibodies in human, mouse, rat for PXN 

    Assay Products for PXN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PXN
    R&D Systems ELISAs for PXN (Paxillin)
    GenScript Custom Assay Services for PXN
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001904 Paxillin
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P49023

    ProtoNet protein and cluster: P49023

    2 Blocks protein domains:
    IPB001781 Zn-binding protein
    IPB001904 Paxillin signature


    UniProtKB/Swiss-Prot: PAXI_HUMAN, P49023
    Similarity: Belongs to the paxillin family
    Similarity: Contains 4 LIM zinc-binding domains


    PXN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAXI_HUMAN, P49023
    Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the
    extracellular matrix (focal adhesion)

         Genatlas biochemistry entry for PXN:
    focal adhesion protein (68kDa),paxillin

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI10604475
    GO:0008013beta-catenin binding IPI17513457
    GO:0008270zinc ion binding IEA--
    GO:0017166vinculin binding IPI9054445
         
    PXN for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PXN:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pxn):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     mortality/aging 

    PXN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pxntm1Smth for PXN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PXN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PXN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PXN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PXN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PXN
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate PXN (see all 42):
    hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-218 hsa-miR-3622b-3p hsa-miR-4280 hsa-miR-203 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidPXN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PXN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PXN

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of PXN

    Clone
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    OriGene clones in human, mouse for PXN (see all 17)
    OriGene ORF clones in mouse, rat for PXN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PXN (NM_025157)
    Sino Biological Human cDNA Clone for PXN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PXN
    Sirion Biotech Customized lentivirus for stable overexpression of PXN 
                         Customized lentivirus expression plasmids for stable overexpression of PXN 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PXN About   (see all 63)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    3Immune response Fc epsilon RI pathway
    VEGF signaling pathway0.39
    Fc-epsilon receptor I signaling in mast cells0.33
    4Development VEGF signaling via VEGFR2 - generic cascades
    Development VEGF signaling via VEGFR2 - generic cascades0.51
    VEGF - VEGF R2 Signaling Pathways 0.39
    5Development HGF signaling pathway
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for PXN (see all 9)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Chemotaxis CXCR4 signaling pathway
    Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Signal transduction PTEN pathway

    1 R&D Systems Pathway for PXN
        VEGF - VEGF R2 Signaling Pathways

    5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PXN (see all 23)
        MAPK Signaling
    PKA Signaling
    Paxillin Interactions
    G12-G13 in Cellular Signaling
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for PXN
        Cytoskeletal Signaling
    Adhesion

    5/10 GeneGo (Thomson Reuters) Pathways for PXN (see all 10)
        Development VEGF signaling via VEGFR2 - generic cascades
    Signal transduction PTEN pathway
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Chemotaxis CXCR4 signaling pathway
    Cell adhesion Ephrins signaling

    5/25 BioSystems Pathways for PXN (see all 25)
        Focal Adhesion
    EGFR1 Signaling Pathway
    Integrin-mediated cell adhesion
    Oncostatin M Signaling Pathway
    Regulation of Actin Cytoskeleton

    1 Sino Biological Pathway for PXN 
        Non-Canonical Wnt Pathway

    5/12        Reactome Pathways for PXN (see all 12)
        Localization of the PINCH-ILK-PARVIN complex to focal adhesions
    Cell-extracellular matrix interactions
    Smooth Muscle Contraction
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Signaling by EGFR in Cancer


    5/8         Kegg Pathways  (Kegg details for PXN) (see all 8):
        Chemokine signaling pathway
    VEGF signaling pathway
    Focal adhesion
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton


    PXN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PXN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/286 Interacting proteins for PXN (P490231, 2, 3 ENSP000002283074) via UniProtKB, MINT, STRING, and/or I2D (see all 286)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF5Q999421, 3, ENSP000003642354EBI-702209,EBI-348482 I2D: score=3 STRING: ENSP00000364235
    ENSG00000183574Q999421, 3EBI-702209,EBI-348482 I2D: score=3 
    ENSG00000223767Q999421, 3EBI-702209,EBI-348482 I2D: score=3 
    ENSG00000225452Q999421, 3EBI-702209,EBI-348482 I2D: score=3 
    ENSG00000227277Q999421, 3EBI-702209,EBI-348482 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0006928cellular component movement IEA--
    GO:0006936muscle contraction TAS--
    GO:0007010cytoskeleton organization IEA--
    GO:0007155cell adhesion NAS10840040

    PXN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PXN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PXN (PAXI)

    10/82 Novoseek inferred chemical compound relationships for PXN gene (see all 82)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 86.6 732 10554546 (9), 11695992 (6), 9230116 (6), 19917054 (6) (see all 99)
    phosphotyrosine 80.6 69 10318759 (3), 8809054 (3), 15554394 (3), 10625692 (2) (see all 47)
    cytochalasin d 76.5 19 11121866 (1), 7536689 (1), 7593197 (1), 11095944 (1) (see all 18)
    herbimycin a 64.9 2 11095944 (1), 17686951 (1)
    1-oleoyl-lyso-phosphatidic acid 60.4 4 9182707 (2), 7510708 (1)
    phenylarsine oxide 55.4 6 10438590 (1), 11839769 (1), 8809054 (1), 9160844 (1) (see all 5)
    phosphatidylinositol 52 12 9748296 (2), 9837978 (1), 17616673 (1), 18632638 (1) (see all 10)
    phalloidin 51.5 2 11581207 (1), 12827288 (1)
    genistein 51.2 5 8888312 (1), 11121866 (1), 10925297 (1), 9632700 (1) (see all 5)
    grgds 46.1 3 10441508 (1), 10954702 (1)

    Search CenterWatch for drugs/clinical trials and news about PXN / PAXI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PXN gene (4 alternative transcripts): 
    NM_001080855.2  NM_001243756.1  NM_002859.3  NM_025157.4  

    Unigene Cluster for PXN:

    Paxillin
    Hs.446336  [show with all ESTs]
    Unigene Representative Sequence: AK128712
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000458477(uc001txx.3) ENST00000228307(uc001txt.3) ENST00000424649(uc001txy.3)
    ENST00000536957 ENST00000323871(uc001txz.3) ENST00000538144 ENST00000550795
    ENST00000547983 ENST00000551327 ENST00000543331 ENST00000546532 ENST00000548912
    ENST00000552550 ENST00000440827 ENST00000547746 ENST00000540221 ENST00000550205
    ENST00000547772
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate PXN (see all 42):
    hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-218 hsa-miR-3622b-3p hsa-miR-4280 hsa-miR-203 hsa-miR-4324
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PXN
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PXN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PXN

    Additional mRNA sequence: 

    AK026695.1 AK122964.1 AK128712.1 AK298057.1 AK299486.1 AK314204.1 BC003647.2 BC006840.1 
    BC010498.1 BC015217.1 BC052611.1 BC136787.1 BC136794.1 BC144410.1 BX648777.1 D86862.1 
    D86863.1 U14588.1 

    24/34 DOTS entries (see all 34):

    DT.95239486  DT.101985119  DT.121112896  DT.91749764  DT.100879907  DT.100879909  DT.95239416  DT.95303914 
    DT.121113350  DT.121113187  DT.121113351  DT.91671802  DT.100837255  DT.102841487  DT.121112725  DT.121113065 
    DT.449204  DT.121113328  DT.99980927  DT.100879918  DT.121113388  DT.121113383  DT.100879910  DT.121113273 

    24/515 AceView cDNA sequences (see all 515):

    CA434176 AI190030 AI365618 BX391817 CB055162 BM907275 AI744239 AW245192 
    BQ888939 BU624512 CA396693 BE465110 BQ706566 BQ019210 BM995580 CB054957 
    BU190995 BQ672239 BG286304 AI453781 AW044517 CB160857 BU500419 BX480482 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PXN (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                                                                -     -           -                                             
    SP2:                                                                    -     -     -     -           -                                             
    SP3:                                                                    -     -     -     -     -                                                   
    SP4:                                                                    -     -     -     -     -     -                                             
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for PXN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PXN expression in normal human tissues (normalized intensities)      PXN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTCAAAA
    PXN Expression
    About this image


    PXN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Lateral Ventricle

    See PXN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PXN

    SOURCE GeneReport for Unigene cluster: Hs.446336
        SABiosciences Expression via Pathway-Focused PCR Arrays including PXN: 
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PXN gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pxn1 , 5 paxillin1, 5 88.66(n)1
    93.57(a)1
      5 (56.10 cM)5
    193031  NM_133915.21  NP_598676.21 
     1155066765 
    chicken
    (Gallus gallus)
    Aves PXN1 paxillin 81.51(n)
    90.31(a)
      395832  NM_204984.1  NP_990315.1 
    lizard
    (Anolis carolinensis)
    Reptilia PXN6
    --
    --
    87(a)
    56(a)
    1 ↔ 1
    possible ortholog
    GL343338.1(430653-450808)
    GL343220.1(2473946-2508040)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978262 paxillin 76.95(n)    AB027499.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb6312 Danio rerio cDNA clone IMAGE5915845, partial cds 77.19(n)    BC054700.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pax1 , 3 cytoskeletal anchoring cytoskeletal
    anchor protein3
    Paxillin1
    70(a)3
    57.22(n)1
    54.21(a)1
      352151  NM_165293.21  NP_724183.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C28H8.63
    pxl-11
    LIM domains3
    Protein PXL-11
    54(a)3
    54.33(n)1
    52.01(a)1
      III(5962097-5964317)3
    1758311  NM_001129205.11  NP_001122677.11 


    ENSEMBL Gene Tree for PXN (if available)
    TreeFam Gene Tree for PXN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PXN gene
    ABLIM32  LIMS12  LIMS3L2  DMTN2  LDB32  FHL52  LPXN2  PDLIM52  
    ENSG000002572072  ABLIM22  LIMS22  FHL22  ABLIM12  PDLIM72  FHL32  FHL12  
    LIMS32  TGFB1I12  
    11 SIMAP similar genes for PXN using alignment to 11 protein entries:     PAXI_HUMAN (see all proteins):
    LPXN    TGFB1I1    CRIP1    LHx4    PDLIM5    LIMS1
    LIMS2    CRIP2    LMO1    LIMS3    LMO4

    PXN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/918 SNPs in PXN are shown (see all 918)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924162741,2
    --120440925(+) TTGTAC/TATGTA 4 -- ds50010--------
    rs1854324321,2
    --120441103(+) GGCAGA/GAGCAA 4 -- ds50010--------
    rs1386125311,2
    --120441208(+) TCCATC/TTGGTG 4 -- ds50010--------
    rs1174951811,2
    F--120441249(+) CTGCTG/AGGACC 4 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1426925341,2
    C--120441353(+) GCCAGC/GTTGGA 4 -- ut310--------
    rs1124759321,2
    F--120441390(+) AATCAG/AATTTT 4 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1473333401,2
    C--120441406(+) AACCAC/TTGACT 4 -- ut310--------
    rs1816014181,2
    --120441452(+) GGGAAC/GATCTA 4 -- ut310--------
    rs124233751,2
    C,F,H--120441519(+) ACCTTT/GGGAGG 4 -- ut31 ese38Minor allele frequency- G:0.01NS EA NA 800
    rs1498289721,2
    --120441531(+) GCTGGA/GCTGAC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for PXN (120648250 - 120703574 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PXN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv905CNV Insertion18451855
    nsv832530CNV Loss17160897
    nsv899555CNV Loss21882294
    nsv519657CNV Loss19592680
    nsv899556CNV Gain21882294
    nsv7238OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602505    OMIM disorders: --

    20/43 diseases for PXN (see all 43):    About MalaCards
    clostridium difficile    cerebral cavernous malformation    chromophobe renal cell carcinoma    cerebral cavernous malformations 3
    cavernous malformation    neurofibromatosis    papilloma    adenoid cystic carcinoma
    adenoiditis    stomach cancer    kaposi's sarcoma    lung cancer
    renal cell carcinoma    non-small cell lung carcinoma    colon cancer    osteosarcoma
    astrocytoma    cerebritis    glioblastoma    gastric cancer

    1 disease from the University of Copenhagen DISEASES database for PXN:
    Cancer

    PXN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/42 Novoseek inferred disease relationships for PXN gene (see all 42)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 2 47.7 2 18486129 (2)
    metastasis 40 27 12910696 (3), 17440071 (2), 18492274 (2), 20369478 (2) (see all 18)
    tumors 31.3 55 17319853 (4), 11759057 (4), 19353596 (3), 12198769 (3) (see all 28)
    glioblastoma 27.2 2 18813807 (1), 18504440 (1)
    cancer 24.2 23 15132756 (3), 17440071 (2), 18380937 (1), 18990162 (1) (see all 14)
    colon cancer 22.2 10 14667936 (2), 16855384 (2), 17982677 (1), 20127017 (1) (see all 8)
    breast carcinoma 20.3 4 17319853 (2), 16360410 (1), 11928806 (1)
    myeloid leukemia chronic 14.3 1 7493940 (1)
    carcinoma lewis lung 13.3 3 12198769 (2), 12856723 (1)
    breast cancer 12.1 21 17319853 (3), 10383144 (3), 20369478 (3), 17047043 (2) (see all 11)

    Genetic Association Database (GAD): PXN
    Human Genome Epidemiology (HuGE) Navigator: PXN (6 documents)

    Export disorders for PXN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PXN gene, integrated from 9 sources (see all 779):
    (articles sorted by number of sources associating them with PXN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. (PubMed id 7534286)1, 2, 3, 9 Salgia R.... Griffin J.D. (1995)
    2. No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer. (PubMed id 19353596)1, 4, 9 Pallier K....Blons H. (2009)
    3. A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. (PubMed id 10749932)1, 2, 9 Kondo A.... Sabe H. (2000)
    4. RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. (PubMed id 12861019)1, 2, 9 Didier C....Ronai Z. (2003)
    5. Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins. (PubMed id 9054445)1, 2, 9 Mazaki Y.... Sabe H. (1997)
    6. Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. (PubMed id 10938112)1, 2, 9 Zhao Z.-S.... Lim L. (2000)
    7. Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2. (PubMed id 19358827)1, 2, 9 Lulo J....Schlessinger J. (2009)
    8. Structural analysis of the interactions between paxillin LD motifs and alpha-parvin. (PubMed id 18940607)1, 2, 9 Lorenz S....Hoellerer M.K. (2008)
    9. The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. (PubMed id 18508764)1, 2, 9 Wang X....Qin J. (2008)
    10. Paxillin and ponsin interact in nascent costameres of muscle cells. (PubMed id 17462669)1, 2, 9 Gehmlich K....Furst D.O. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5829 HGNC: 9718 AceView: PXN Ensembl:ENSG00000089159 euGenes: HUgn5829
    ECgene: PXN Kegg: 5829 H-InvDB: PXN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PXN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PXN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PXN gene:
    Search GeneIP for patents involving PXN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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