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Aliases for PXN Gene

Aliases for PXN Gene

  • Paxillin 2 3 5

External Ids for PXN Gene

Previous GeneCards Identifiers for PXN Gene

  • GC12M119521
  • GC12M120174
  • GC12M120431
  • GC12M119060
  • GC12M119110
  • GC12M120648
  • GC12M117656

Summaries for PXN Gene

Entrez Gene Summary for PXN Gene

  • This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

GeneCards Summary for PXN Gene

PXN (Paxillin) is a Protein Coding gene. Diseases associated with PXN include corneal opacification and other ocular anomalies and prostate cancer. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling by GPCR. GO annotations related to this gene include protein kinase binding and integrin binding. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for PXN Gene

  • Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Gene Wiki entry for PXN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PXN Gene

Genomics for PXN Gene

Regulatory Elements for PXN Gene

Promoters for PXN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PXN on UCSC Golden Path with GeneCards custom track

Genomic Location for PXN Gene

Chromosome:
12
Start:
120,210,439 bp from pter
End:
120,265,771 bp from pter
Size:
55,333 bases
Orientation:
Minus strand

Genomic View for PXN Gene

Genes around PXN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PXN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PXN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXN Gene

Proteins for PXN Gene

  • Protein details for PXN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49023-PAXI_HUMAN
    Recommended name:
    Paxillin
    Protein Accession:
    P49023
    Secondary Accessions:
    • B2RAI3
    • B7ZMB4
    • O14970
    • O14971
    • O60360
    • Q5HYA4

    Protein attributes for PXN Gene

    Size:
    591 amino acids
    Molecular mass:
    64505 Da
    Quaternary structure:
    • Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with PTK6. Interacts with SORBS1, PARVA and PARVB.

    Three dimensional structures from OCA and Proteopedia for PXN Gene

    Alternative splice isoforms for PXN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PXN Gene

Proteomics data for PXN Gene at MOPED

Post-translational modifications for PXN Gene

  • Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PXN Gene

Domains & Families for PXN Gene

Gene Families for PXN Gene

Protein Domains for PXN Gene

Suggested Antigen Peptide Sequences for PXN Gene

Graphical View of Domain Structure for InterPro Entry

P49023

UniProtKB/Swiss-Prot:

PAXI_HUMAN :
  • Contains 4 LIM zinc-binding domains.
  • Belongs to the paxillin family.
Domain:
  • Contains 4 LIM zinc-binding domains.
Family:
  • Belongs to the paxillin family.
genes like me logo Genes that share domains with PXN: view

Function for PXN Gene

Molecular function for PXN Gene

GENATLAS Biochemistry:
focal adhesion protein (68kDa),paxillin
UniProtKB/Swiss-Prot Function:
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Gene Ontology (GO) - Molecular Function for PXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017166 vinculin binding IPI 9054445
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with PXN: view
genes like me logo Genes that share phenotypes with PXN: view

Animal Models for PXN Gene

MGI Knock Outs for PXN:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PXN Gene

Localization for PXN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXN Gene

Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex. Note=Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389). {ECO:0000250, ECO:0000269 PubMed:23128389}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PXN Gene COMPARTMENTS Subcellular localization image for PXN gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for PXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with PXN: view

Pathways & Interactions for PXN Gene

genes like me logo Genes that share pathways with PXN: view

SIGNOR curated interactions for PXN Gene

Activates:
Other effect:

Gene Ontology (GO) - Biological Process for PXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IEA --
GO:0007172 signal complex assembly TAS 9054445
genes like me logo Genes that share ontologies with PXN: view

Drugs & Compounds for PXN Gene

(37) Drugs for PXN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(45) Additional Compounds for PXN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PXN: view

Transcripts for PXN Gene

Unigene Clusters for PXN Gene

Paxillin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PXN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5:
SP6: - - - -
SP7: -
SP8: - - -
SP9: -
SP10:

Relevant External Links for PXN Gene

GeneLoc Exon Structure for
PXN
ECgene alternative splicing isoforms for
PXN

Expression for PXN Gene

mRNA expression in normal human tissues for PXN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PXN Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for PXN Gene

This gene is overexpressed in NK cells (15.2), Peripheral blood mononuclear cells (10.0), and Bone marrow stromal cell (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PXN Gene



SOURCE GeneReport for Unigene cluster for PXN Gene Hs.446336

genes like me logo Genes that share expression patterns with PXN: view

Protein tissue co-expression partners for PXN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PXN Gene

Orthologs for PXN Gene

This gene was present in the common ancestor of animals.

Orthologs for PXN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PXN 36
  • 95 (a)
OneToOne
PXN 35
  • 99.55 (n)
  • 99.66 (a)
cow
(Bos Taurus)
Mammalia PXN 35
  • 89.93 (n)
  • 93.34 (a)
PXN 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PXN 35
  • 91.79 (n)
  • 96.3 (a)
PXN 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pxn 36
  • 90 (a)
OneToOne
Pxn 16
Pxn 35
  • 88.56 (n)
  • 93.45 (a)
oppossum
(Monodelphis domestica)
Mammalia PXN 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PXN 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pxn 35
  • 88.16 (n)
  • 94.51 (a)
chicken
(Gallus gallus)
Aves PXN 35
  • 81.26 (n)
  • 89.74 (a)
PXN 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PXN 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397826 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pxn 35
  • 73.19 (n)
  • 81.94 (a)
Str.15031 35
zebrafish
(Danio rerio)
Actinopterygii PXN (1 of 3) 36
  • 33 (a)
OneToMany
pxna 36
  • 89 (a)
OneToMany
pxna 36
  • 91 (a)
OneToMany
LOC565130 35
  • 69.65 (n)
  • 73.93 (a)
sbcb631 35
fruit fly
(Drosophila melanogaster)
Insecta Pax 37
  • 70 (a)
Pax 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C28H8.6 37
  • 54 (a)
pxl-1 36
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11495 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9134 36
  • 54 (a)
OneToMany
Species with no ortholog for PXN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PXN Gene

ENSEMBL:
Gene Tree for PXN (if available)
TreeFam:
Gene Tree for PXN (if available)

Paralogs for PXN Gene

genes like me logo Genes that share paralogs with PXN: view

Variants for PXN Gene

Sequence variations from dbSNP and Humsavar for PXN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4767884 - 120,224,174(+) GGAGC(C/T)GCTGG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs25662 -- 120,214,855(-) CCGCG(A/C/G/T)TGCTA nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs1179361 -- 120,249,400(+) AGGCC(A/G)TTAGG intron-variant
rs1182859 -- 120,255,485(+) ggtca(A/G)gagtt intron-variant
rs1182860 -- 120,256,487(+) GGGAC(A/C)TCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PXN Gene

Variant ID Type Subtype PubMed ID
nsv899555 CNV Loss 21882294
nsv519657 CNV Loss 19592680
nsv832530 CNV Loss 17160897
nsv7238 OTHER Inversion 18451855
nsv905 CNV Insertion 18451855
nsv899556 CNV Gain 21882294

Variation tolerance for PXN Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PXN Gene

HapMap Linkage Disequilibrium report
PXN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXN Gene

Disorders for PXN Gene

MalaCards: The human disease database

(3) MalaCards diseases for PXN Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
corneal opacification and other ocular anomalies
  • sclerocornea with other ocular anomalies
prostate cancer
  • prostate cancer, hereditary, 5
breast adenocarcinoma
  • adenocarcinoma of breast
- elite association - COSMIC cancer census association via MalaCards
Search PXN in MalaCards View complete list of genes associated with diseases

Relevant External Links for PXN

Genetic Association Database (GAD)
PXN
Human Genome Epidemiology (HuGE) Navigator
PXN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PXN
genes like me logo Genes that share disorders with PXN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PXN Gene

Publications for PXN Gene

  1. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. (PMID: 7534286) Salgia R. … Griffin J.D. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin. (PMID: 19917054) Tanaka T. … Miyasaka M. (Cancer Sci. 2010) 3 23
  3. Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. (PMID: 20133777) Zhao Y. … Wang Z. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  4. An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. (PMID: 19401330) Deakin N.O. … Humphries M.J. (J. Cell. Sci. 2009) 3 23
  5. Paxillin is involved in the differential regulation of endothelial barrier by HGF and VEGF. (PMID: 18664639) Birukova A.A. … Birukov K.G. (Am. J. Respir. Cell Mol. Biol. 2009) 3 23

Products for PXN Gene

Sources for PXN Gene

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