Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PXN Gene

protein-coding   GIFtS: 68
GCID: GC12M120648

paxillin
 Explore 51 diseases affiliated with
PXN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PXN    

Aliases
for PXN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Paxillin1

External Ids:    HGNC: 97181   Entrez Gene: 58292   Ensembl: ENSG000000891597   OMIM: 6025055   UniProtKB: P490233   

Export aliases for PXN gene to outside databases

Previous GC identifers: GC12M119521 GC12M120174 GC12M120431 GC12M119060 GC12M119110 GC12M117656


Summaries
for PXN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PXN:
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the
extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been
described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well
as physiological properties (PMID:9054445). (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: PAXI_HUMAN, P49023
Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular
matrix (focal adhesion)

Gene Wiki entry for PXN (Paxillin)


Genomic Views
for PXN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PXN gene promoter:
         E2F-1   E2F   AP-1   ATF-2   STAT3   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PXN promoter sequence
   Search SABiosciences Chromatin IP Primers for PXN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PXN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24

PXN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PXN gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120648:  view genomic region     (about GC identifiers)

Start:
 120,648,250 bp from pter      End:
 120,703,574 bp from pter
Size:
 55,325 bases      Orientation:
 minus strand

Proteins
for PXN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PAXI_HUMAN, P49023 (See protein sequence)
Recommended Name: Paxillin  
Size: 591 amino acids; 64505 Da
Subunit: Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2
domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only
weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1. Component of cytoplasmic complexes, which also
contain GIT1, ARHGEF6 and PAK1 (By similarity). Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2. Interacts with
unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is
prolactin-dependent. Interacts with PTK6. Interacts with SORBS1, PARVA and PARVB
Subcellular location: Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex (By similarity).
Note=Colocalizes with integrins at the cell periphery (By similarity)
6/18 PDB 3D structures from and Proteopedia for PXN (see all 18):
1KKY (3D)        1KL0 (3D)        1OW6 (3D)        1OW7 (3D)        1OW8 (3D)        2K2R (3D)    
Secondary accessions: B2RAI3 B7ZMB4 O14970 O14971 O60360 Q5HYA4
Alternative splicing: 4 isoforms:  P49023-1   P49023-2   P49023-3   P49023-4   

Explore the universe of human proteins at neXtProt for PXN: NX_P49023

Post-translational modifications:

  • Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell
    • adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
    Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during
    oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1
    via CRK/CrKII, thereby promoting migration and invasion1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49023

    • PXN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001074324.1  NP_001230685.1  NP_002850.2  NP_079433.3  

    ENSEMBL proteins: 
     ENSP00000395536   ENSP00000228307   ENSP00000391283   ENSP00000443887   ENSP00000449198  
     ENSP00000446893   ENSP00000443745   ENSP00000447180   ENSP00000446607   ENSP00000446650  
     ENSP00000267257   ENSP00000380643  
    Reactome Protein details: P49023
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PXN
    OriGene Protein Over-expression Lysate: PXN
    OriGene Custom Protein Services for PXN 
    GenScript Custom Purified and Recombinant Proteins Services for PXN
    Novus Biologicals PXN Proteins
    Novus Biologicals PXN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton ----
    GO:0005875microtubule associated complex TAS10840040
    GO:0005886plasma membrane TAS--
    GO:0005925focal adhesion IDA--
    GO:0005938cell cortex IEA--


    PXN for ontologies           About GeneDecksing



    PXN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PXN
    R&D Systems Antibodies for PXN (Paxillin)
    Cell Signaling Technology (CST) Antibodies for PXN  (PXN iso2)
    OriGene Antibodies (see all 7): PXN
    OriGene Custom Antibody Services for PXN 
    GenScript Custom Superior Antibodies Services for PXN
    Novus Biologicals PXN Antibodies
    Abcam antibodies for PXN 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for PXN

    Assay Products for PXN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for PXN (Paxillin)
    GenScript Custom Assay Services for PXN
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PXN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PXN for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001904 Paxillin
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P49023

    ProtoNet protein and cluster: P49023

    2 Blocks protein families:
    IPB001781 Zn-binding protein
    IPB001904 Paxillin signature


    UniProtKB/Swiss-Prot: PAXI_HUMAN, P49023
    Similarity: Belongs to the paxillin family
    Similarity: Contains 4 LIM zinc-binding domains


    Function
    for PXN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PAXI_HUMAN, P49023
    Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular
    matrix (focal adhesion)

         Genatlas biochemistry entry for PXN:
    focal adhesion protein (68kDa),paxillin

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): PXN
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PXN
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate PXN (see all 42):
    hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-218 hsa-miR-3622b-3p hsa-miR-4280 hsa-miR-203 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmid: PXN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PXN (see all 7)
    OriGene shRNA RFP: PXN
    OriGene siRNA: PXN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PXN

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PXN

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PXN (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PXN (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): PXN (NM_025157)
    Sino Biological Human cDNA Clone for PXN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PXN 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PXN
    Search LifeMap BioReagents cell lines for PXN

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXN

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI--
    GO:0008013beta-catenin binding IPI17513457
    GO:0008270zinc ion binding IEA--
    GO:0017166vinculin binding IPI9054445


    PXN for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for PXN:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
         Mouse knock-out Pxntm1Smth for PXN
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pxn):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     mortality/aging 

    PXN for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PXN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/59 super-pathways (see all 59) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Integrin outside-in signaling0.37
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling_Integrin outside-in signaling0.37
    2Focal Adhesion
    		Focal Adhesion1.00
    		Integrin-mediated cell adhesion0.38
    		Focal adhesion0.66
    		HGF Pathway0.24
    3Integrin Pathway
    		Integrin Pathway1.00
    		Transendothelial Migration of Leukocytes0.38
    		FAK1 Signaling0.67
    4Cell adhesion_Ephrins signaling
    		Cell adhesion_Ephrins signaling1.00
    		EPHB forward signaling0.30
    		Cell adhesion Ephrins signaling1.00
    5G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		Immune response Role of integrins in NK cells cytotoxicity0.28
    		Oncostatin M Signaling Pathway0.15
    		Immune response_Role of integrins in NK cells cytotoxicity0.28

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/9 EMD Millipore Pathways for PXN (see all 9)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Chemotaxis CXCR4 signaling pathway
    Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Signal transduction PTEN pathway

    5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PXN (see all 23)
        MAPK Signaling
    PKA Signaling
    Paxillin Interactions
    G12-G13 in Cellular Signaling
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for PXN
        Cytoskeletal Signaling
    Adhesion

    5/10 GeneGo (Thomson Reuters) Pathways for PXN (see all 10)
        Development VEGF signaling via VEGFR2 - generic cascades
    Signal transduction PTEN pathway
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Chemotaxis CXCR4 signaling pathway
    Cell adhesion Ephrins signaling

    5/24 BioSystems Pathways for PXN (see all 24) 
        Integrin-mediated cell adhesion
    Oncostatin M Signaling Pathway
    Focal Adhesion
    EGFR1 Signaling Pathway
    IL-3 Signaling Pathway

    5/12        Reactome Pathways for PXN (see all 12)
        Localization of the PINCH-ILK-PARVIN complex to focal adhesions
    Cell-extracellular matrix interactions
    Smooth Muscle Contraction
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Signaling by EGFR in Cancer


    5/6         Kegg Pathways  (Kegg details for PXN) (see all 6):
        Chemokine signaling pathway
    VEGF signaling pathway
    Focal adhesion
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton


    PXN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PXN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/271 Interacting proteins for PXN (P490231, 2, 3 ENSP000002283074) via UniProtKB, MINT, STRING, and/or I2D (see all 271)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061242, 3, ENSP000003409444MINT-6169464 MINT-6169451 MINT-6169440 I2D: score=3 STRING: ENSP00000340944
    CRKLP461092, 3, ENSP000003463004MINT-8029753 MINT-8033642 I2D: score=4 STRING: ENSP00000346300
    APCP250542, 3, ENSP000002574304MINT-7891130 MINT-7897100 I2D: score=2 STRING: ENSP00000257430
    CRKP461082, 3, ENSP000003005744MINT-6763928 I2D: score=6 STRING: ENSP00000300574
    SRCP129312, 3, ENSP000003509414MINT-6169464 I2D: score=5 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0006928cellular component movement IEA--
    GO:0006936muscle contraction TAS--
    GO:0007010cytoskeleton organization IEA--
    GO:0007155cell adhesion NAS10840040


    PXN for ontologies           About GeneDecksing



    Drugs & Compounds
    for PXN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PXN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PXN
    10/82 Novoseek chemical compound relationships for PXN gene (see all 82)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 86.6 732 10554546 (9), 11695992 (6), 9230116 (6), 19917054 (6) (see all 99)
    phosphotyrosine 80.6 69 10318759 (3), 8809054 (3), 15554394 (3), 10625692 (2) (see all 47)
    cytochalasin d 76.5 19 11121866 (1), 7536689 (1), 7593197 (1), 11095944 (1) (see all 18)
    herbimycin a 64.9 2 11095944 (1), 17686951 (1)
    1-oleoyl-lyso-phosphatidic acid 60.4 4 9182707 (2), 7510708 (1)
    phenylarsine oxide 55.4 6 10438590 (1), 11839769 (1), 8809054 (1), 9160844 (1) (see all 5)
    phosphatidylinositol 52 12 9748296 (2), 9837978 (1), 17616673 (1), 18632638 (1) (see all 10)
    phalloidin 51.5 2 11581207 (1), 12827288 (1)
    genistein 51.2 5 8888312 (1), 11121866 (1), 10925297 (1), 9632700 (1) (see all 5)
    grgds 46.1 3 10441508 (1), 10954702 (1)

    Search CenterWatch for drugs/clinical trials and news about PXN / PAXI 

    Transcripts
    for PXN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PXN gene (4 alternative transcripts): 
    NM_001080855.2  NM_001243756.1  NM_002859.3  NM_025157.4  

    Unigene Cluster for PXN:

    Paxillin
    Hs.446336  [show with all ESTs]
    Unigene Representative Sequence: AK128712
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000458477(uc001txx.3) ENST00000228307(uc001txt.3) ENST00000424649(uc001txy.3)
    ENST00000536957 ENST00000323871(uc001txz.3) ENST00000538144 ENST00000550795
    ENST00000547983 ENST00000551327 ENST00000543331 ENST00000546532 ENST00000548912
    ENST00000552550 ENST00000440827 ENST00000547746 ENST00000540221 ENST00000550205
    ENST00000547772

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): PXN
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PXN
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate PXN (see all 42):
    hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-218 hsa-miR-3622b-3p hsa-miR-4280 hsa-miR-203 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmid: PXN 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PXN (see all 7)
    OriGene shRNA RFP: PXN
    OriGene siRNA: PXN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PXN
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PXN (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PXN (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): PXN (NM_025157)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PXN 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PXN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PXN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PXN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PXN

    Additional cDNA sequence: 

    AK026695.1 AK122964.1 AK128712.1 AK298057.1 AK299486.1 AK314204.1 BC003647.2 BC006840.1 
    BC010498.1 BC015217.1 BC052611.1 BC136787.1 BC136794.1 BC144410.1 BX648777.1 D86862.1 
    D86863.1 U14588.1 

    24/34 DOTS entries (see all 34):

    DT.95239486  DT.101985119  DT.121112896  DT.91749764  DT.100879907  DT.100879909  DT.95239416  DT.95303914 
    DT.121113350  DT.121113187  DT.121113351  DT.91671802  DT.100837255  DT.102841487  DT.121112725  DT.121113065 
    DT.449204  DT.121113328  DT.99980927  DT.100879918  DT.121113388  DT.121113383  DT.100879910  DT.121113273 

    24/515 AceView cDNA sequences (see all 515):

    AI282919 BM983564 AI004668 AW245192 BU541548 BC015217 CB160857 AW005127 
    CA865519 BQ706566 BE877082 BU190995 AA524022 CB140461 AW276466 BU741870 
    BQ672239 BE906566 BQ917265 BC010498 BU540982 BQ898682 AI953973 BQ216207 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PXN (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                                                                -     -           -                                             
    SP2:                                                                    -     -     -     -           -                                             
    SP3:                                                                    -     -     -     -     -                                                   
    SP4:                                                                    -     -     -     -     -     -                                             
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for PXN

    Expression
    for PXN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PXN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTTCAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PXN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/24 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 24) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    BoneAutopod Epiphyseal EndPrechondrocytesBone, Cartilage
    BoneStylopod Epiphyseal EndPrechondrocytesBone, Cartilage
    BoneZeugopod Epiphyseal EndPrechondrocytesBone, Cartilage
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleThoracic Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PXN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PXN

    SOURCE GeneReport for Unigene cluster: Hs.446336
        SABiosciences Expression via Pathway-Focused PCR Arrays including PXN: 
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PXN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PXN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PXN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PXN
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXN

    Orthologs
    for PXN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PXN gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PXN1 paxillin 81.51(n)
    90.31(a)    		   395832  NM_204984.1  NP_990315.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PXN6
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343338.1(430653-446672)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3978262 paxillin 76.95(n)    AB027499.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb6312 Danio rerio cDNA clone IMAGE5915845, partial cds 77.19(n)    BC054700.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pax1 , 3 cytoskeletal anchoring cytoskeletal anchor
    protein3
    Paxillin1    		 70(a)3
    57.22(n)1
    54.21(a)1    		   352151  NM_165293.21  NP_724183.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea C28H8.63
    pxl-11    		 LIM domains3
    Protein PXL-11    		 54(a)3
    54.33(n)1
    52.01(a)1    		   III(5962097-5964317)3
    1758311  NM_001129205.11  NP_001122677.11 


    ENSEMBL Gene Tree for PXN (if available)
    TreeFam Gene Tree for PXN (if available) 

    Paralogs
    for PXN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PXN gene
    ABLIM32  LIMS12  LIMS3L2  FHL52  LDB32  LPXN2  ABLIM22  PDLIM52  
    ENSG000002572072  LIMS22  FHL22  ABLIM12  PDLIM72  EPB492  FHL32  FHL12  
    TGFB1I12  LIMS32  
    13 SIMAP similar genes for PXN using alignment to 11 protein entries:     PAXI_HUMAN (see all proteins):
    LPXN    TGFB1I1    CRIP1    LHx4    PDLIM5    LIMS1
    LIMS2    CRIP2    LMO1    LIMS3    LMO4    AAG11
    LMO3

    PXN for paralogs           About GeneDecksing



    Genomic Variants
    for PXN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/789 NCBI SNPs in PXN are shown (see all 789)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1124759321,2
    		--117656547(+) AATCAG/AATTTT 4 -- ut311Minor allele frequency- A:0.50CSA 2
    rs124233751,2
    		C,F,H,--117656676(+) ACCTTT/GGGAGG 4 -- ut31 ese38Minor allele frequency- G:0.01NS EA NA 800
    rs1114538341,2
    		C--117656877(+) CCAGAG/AGAGCC 4 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1130688491,2
    		C,--117657101(+) TGGGGG/ACTCAG 4 -- ut311Minor allele frequency- A:0.50WA 2
    rs360192721,2
    		C--117657106(+) GCTCAG/TAAGGT 4 -- ut311Minor allele frequency- T:0.00NA 2
    rs101287701,2
    		C,F,H,--117657850(+) ATTGTC/ATGGAG 4 -- ut31 ese39Minor allele frequency- A:0.07NS EA NA WA 1032
    rs734128961,2
    		C,--117658089(+) GAGTGG/AGCAGC 4 -- ut312Minor allele frequency- A:0.02WA 120
    rs110650511,2
    		H--117659690(+) AGGACC/TTACTG 4 -- int14Minor allele frequency- T:0.00NS EA 418
    rs758771141,2
    		C,--117661324(-) GACACC/TGTACC 5 R C int1 mis10--------
    rs799975571,2
    		C--117661592(+) GCTGCC/TCCGCC 5 S G int1 mis10--------

    HapMap Linkage Disequilibrium report for PXN (120648250 - 120703574 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PXN
         1 CNV: 35051
         1 Inversion: 37132

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PXN
    DNA2.0 Custom Variant and Variant Library Synthesis for PXN

    Disorders / Diseases
    for PXN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PXN for disorders           About GeneDecksing

    OMIM gene information: 602505    OMIM disorders: --

    20/51 diseases for PXN (see all 51):    About MalaCards
    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3    non-small cell lung carcinoma
    clostridium difficile    chromophobe renal cell carcinoma    adenoid cystic carcinoma    oral squamous cell carcinoma
    renal cell carcinoma    squamous cell carcinoma    carcinoma    neurofibromatosis
    kaposi's sarcoma    papilloma    adenoiditis    lung carcinoma
    stomach cancer    hepatocellular carcinoma    alzheimer's disease    colon cancer

    1 disease from the University of Copenhagen DISEASES database for PXN:
    Cancer

    10/42 Novoseek disease relationships for PXN gene (see all 42)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 2 47.7 2 18486129 (2)
    metastasis 40 27 12910696 (3), 17440071 (2), 18492274 (2), 20369478 (2) (see all 18)
    tumors 31.3 55 17319853 (4), 11759057 (4), 19353596 (3), 12198769 (3) (see all 28)
    glioblastoma 27.2 2 18813807 (1), 18504440 (1)
    cancer 24.2 23 15132756 (3), 17440071 (2), 18380937 (1), 18990162 (1) (see all 14)
    colon cancer 22.2 10 14667936 (2), 16855384 (2), 17982677 (1), 20127017 (1) (see all 8)
    breast carcinoma 20.3 4 17319853 (2), 16360410 (1), 11928806 (1)
    myeloid leukemia chronic 14.3 1 7493940 (1)
    carcinoma lewis lung 13.3 3 12198769 (2), 12856723 (1)
    breast cancer 12.1 21 17319853 (3), 10383144 (3), 20369478 (3), 17047043 (2) (see all 11)

    Human Genome Epidemiology (HuGE) Navigator: PXN (6 documents)

    Export disorders for PXN gene to outside databases

    Publications
    for PXN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PXN gene, integrated from 9 sources (see all 768):
    (articles sorted by number of sources associating them with PXN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. (PubMed id 7534286)1, 2, 3, 9 Salgia R.... Griffin J.D. (1995)
    2. A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. (PubMed id 10749932)1, 2, 9 Kondo A.... Sabe H. (2000)
    3. RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. (PubMed id 12861019)1, 2, 9 Didier C....Ronai Z. (2003)
    4. Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins. (PubMed id 9054445)1, 2, 9 Mazaki Y.... Sabe H. (1997)
    5. Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. (PubMed id 10938112)1, 2, 9 Zhao Z.-S.... Lim L. (2000)
    6. Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2. (PubMed id 19358827)1, 2, 9 Lulo J....Schlessinger J. (2009)
    7. Structural analysis of the interactions between paxillin LD motifs and alpha-parvin. (PubMed id 18940607)1, 2, 9 Lorenz S....Hoellerer M.K. (2008)
    8. The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. (PubMed id 18508764)1, 2, 9 Wang X....Qin J. (2008)
    9. Paxillin and ponsin interact in nascent costameres of muscle cells. (PubMed id 17462669)1, 2, 9 Gehmlich K....Furst D.O. (2007)
    10. Structural basis for paxillin binding and focal adhesion targeting of beta-parvin. (PubMed id 22869380)1, 2 Stiegler A.L....Boggon T.J. (2012)

    External Searches for PXN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PXN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5829 HGNC: 9718 AceView: PXN Ensembl:ENSG00000089159 euGenes: HUgn5829
    ECgene: PXN Kegg: 5829 H-InvDB: PXN

    Other Databases showing PXN gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PXN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PXN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PXN Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PXN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PXN gene:
    Search GeneIP for patents involving PXN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PXN gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PXN
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PXN (Paxillin)   Browse Cell Culture Products  
     ELISAs for PXN (Paxillin)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for PXN   OriGene shRNA RFP for PXN  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PXN   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PXN  
     OriGene Protein Over-expression Lysate for PXN   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PXN   OriGene 3'-UTR Clone for PXN  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PXN   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PXN  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for PXN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PXN   OriGene Custom Protein Services for PXN  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PXN
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PXN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PXN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PXN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PXN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PXN
     GenScript Custom Purified and Recombinant Proteins Services for PXN GenScript cDNA clones with any tag delivered in your preferred vector for PXN
     GenScript Custom Assay Services for PXN GenScript Custom Superior Antibodies Services for PXN
     GenScript Custom overexpressing Cell Line Services for PXN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PXN 
    (PXN iso2)

     Regulatory tfbs in PXN promoter
     Search Chromatin IP Primers for PXN
     RT2 qPCR Primer Assay in human, mouse, rat PXN
     GNC Network for PXN
     SABiosciences PCR Arrays including human, mouse, rat PXN
     Search Tocris compounds for PXN
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for PXN
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PXN antibodies
     PXN proteins
     PXN lysates
     Antibodies for PXN
     See all of Abcam's Antibodies, Kits and Proteins for PXN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for PXN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXN
     SwitchGear 3'UTR luciferase reporter plasmids for PXN
     SwitchGear Promoter luciferase reporter plasmids for PXN
     ThermoFisher Antibody for PXN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PXN
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PXN gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4