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PXN Gene

protein-coding   GIFtS: 69
GCID: GC12M120648

Paxillin

  Search for PXN
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
paxillin1 2

External Ids:    HGNC: 97181   Entrez Gene: 58292   Ensembl: ENSG000000891597   OMIM: 6025055   UniProtKB: P490233   

Export aliases for PXN gene to outside databases

Previous GC identifers: GC12M119521 GC12M120174 GC12M120431 GC12M119060 GC12M119110 GC12M117656


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PXN Gene:
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the
extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have
been described for this gene. These isoforms exhibit different expression pattern, and have different
biochemical, as well as physiological properties (PMID:9054445). (provided by RefSeq, Aug 2011)

GeneCards Summary for PXN Gene:
PXN (paxillin) is a protein-coding gene. GO annotations related to this gene include beta-catenin binding and protein kinase binding. An important paralog of this gene is LIMS1.

UniProtKB/Swiss-Prot: PAXI_HUMAN, P49023
Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the
extracellular matrix (focal adhesion)

Gene Wiki entry for PXN (Paxillin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PXN gene promoter:
         E2F-1   E2F   AP-1   ATF-2   STAT3   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPXN promoter sequence
   Search Chromatin IP Primers for PXN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PXN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24

PXN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PXN gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120648:  view genomic region     (about GC identifiers)

Start:
120,648,250 bp from pter      End:
120,703,574 bp from pter
Size:
55,325 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAXI_HUMAN, P49023 (See protein sequence)
Recommended Name: Paxillin  
Size: 591 amino acids; 64505 Da
Subunit: Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the
SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but
only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1. Component of cytoplasmic complexes,
which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2.
Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction
is prolactin-dependent. Interacts with PTK6. Interacts with SORBS1, PARVA and PARVB
Selected PDB 3D structures from and Proteopedia for PXN (see all 18):
1KKY (3D)        1KL0 (3D)        1OW6 (3D)        1OW7 (3D)        1OW8 (3D)        2K2R (3D)    
Secondary accessions: B2RAI3 B7ZMB4 O14970 O14971 O60360 Q5HYA4
Alternative splicing: 4 isoforms:  P49023-1   P49023-2   P49023-3   P49023-4   

Explore the universe of human proteins at neXtProt for PXN: NX_P49023

Explore proteomics data for PXN at MOPED

Post-translational modifications: 

  • Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell
    adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
    Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA)
    during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the
    activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PXN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001074324.1  NP_001230685.1  NP_002850.2  NP_079433.3  

    ENSEMBL proteins: 
     ENSP00000395536   ENSP00000228307   ENSP00000391283   ENSP00000443887   ENSP00000449198  
     ENSP00000446893   ENSP00000443745   ENSP00000447180   ENSP00000446607   ENSP00000446650  
     ENSP00000267257   ENSP00000380643  
    Reactome Protein details: P49023

    PXN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PXN
    OriGene Protein Over-expression Lysate for PXN
    OriGene MassSpec for PXN
    OriGene Custom Protein Services for PXN
    GenScript Custom Purified and Recombinant Proteins Services for PXN
    Novus Biologicals PXN Proteins
    Novus Biologicals PXN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PXN 

    PXN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PXN
    R&D Systems Antibodies for PXN (Paxillin)
    Cell Signaling Technology (CST) Antibodies for PXN 
    OriGene Antibodies for PXN
    OriGene Custom Antibody Services for PXN
    Novus Biologicals PXN Antibodies
    Abcam antibodies for PXN
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PXN
    LSBio Antibodies in human, mouse, rat for PXN

    PXN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PXN
    R&D Systems ELISAs for PXN (Paxillin)
    GenScript Custom Assay Services for PXN
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PXN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001904 Paxillin
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P49023

    ProtoNet protein and cluster: P49023

    2 Blocks protein domains:
    IPB001781 Zn-binding protein
    IPB001904 Paxillin signature


    UniProtKB/Swiss-Prot: PAXI_HUMAN, P49023
    Similarity: Belongs to the paxillin family
    Similarity: Contains 4 LIM zinc-binding domains


    Find genes that share domains with PXN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAXI_HUMAN, P49023
    Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the
    extracellular matrix (focal adhesion)

         Genatlas biochemistry entry for PXN:
    focal adhesion protein (68kDa),paxillin

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI10604475
    GO:0008013beta-catenin binding IPI17513457
    GO:0008270zinc ion binding IEA--
    GO:0017166vinculin binding IPI9054445
         
    Find genes that share ontologies with PXN           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PXN:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pxn):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size/body 
     mortality/aging 

    Find genes that share phenotypes with PXN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pxntm1Smth for PXN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PXN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PXN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PXN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PXN

    miRNA
    Products:
        
    miRTarBase miRNAs that target PXN:
    hsa-mir-221-3p (MIRT046850), hsa-mir-124-3p (MIRT023030), hsa-mir-137 (MIRT007346), hsa-mir-92a-3p (MIRT049136), hsa-mir-335-5p (MIRT018650)

    Block miRNA regulation of human, mouse, rat PXN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PXN (see all 42):
    hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-218 hsa-miR-3622b-3p hsa-miR-4280 hsa-miR-203 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidPXN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PXN
    Predesigned siRNA for gene silencing in human, mouse, rat PXN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PXN

    Clone
    Products:
         
    OriGene clones in human, mouse for PXN (see all 19)
    OriGene ORF clones in mouse, rat for PXN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PXN (NM_025157)
    Sino Biological Human cDNA Clone for PXN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PXN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PXN
    Browse ESI BIO Cell Lines and PureStem Progenitors for PXN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXN

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12227) for PXN 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAXI_HUMAN, P49023: Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex (By
    similarity). Note=Colocalizes with integrins at the cell periphery (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus3
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton ----
    GO:0005875microtubule associated complex TAS10840040

    Find genes that share ontologies with PXN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PXN About   (see all 60)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    HGF Pathway0.34
    2Immune response Fc epsilon RI pathway
    VEGF signaling pathway0.39
    Fc-epsilon receptor I signaling in mast cells0.34
    VEGF - VEGF R2 Signaling Pathways0.35
    3EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    4Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    5EPHB forward signaling
    EPHB forward signaling0.30
    Cell adhesion Ephrins signaling0.30


    Find genes that share SuperPaths with PXN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PXN
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PXN (see all 23)
        MAPK Signaling
    PKA Signaling
    Paxillin Interactions
    G12-G13 in Cellular Signaling
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for PXN
        Cytoskeletal Signaling
    Adhesion

    Selected GeneGo (Thomson Reuters) Pathways for PXN (see all 10)
        Development VEGF signaling via VEGFR2 - generic cascades
    Signal transduction PTEN pathway
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Chemotaxis CXCR4 signaling pathway
    Cell adhesion Ephrins signaling

    Selected BioSystems Pathways for PXN (see all 25)
        Focal Adhesion
    Integrin-mediated cell adhesion
    EGFR1 Signaling Pathway
    Oncostatin M Signaling Pathway
    IL-6 Signaling Pathway

    1 Sino Biological Pathway for PXN
        Non-Canonical Wnt Pathway

    4 Reactome Pathways for PXN
        Localization of the PINCH-ILK-PARVIN complex to focal adhesions
    GAB1 signalosome
    Smooth Muscle Contraction
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components


    Selected Kegg Pathways  (Kegg details for PXN) (see all 8):
        Chemokine signaling pathway
    VEGF signaling pathway
    Focal adhesion
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PXN: 
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PXN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PXN (P490231, 2, 3 ENSP000002283074) via UniProtKB, MINT, STRING, and/or I2D (see all 354)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061241, 2, 3, ENSP000003409444EBI-702209,EBI-297779 MINT-6169464 MINT-6169451 MINT-6169440 I2D: score=3 STRING: ENSP00000340944
    RNF5Q999421, 3, ENSP000003642354EBI-702209,EBI-348482 I2D: score=3 STRING: ENSP00000364235
    ENSG00000183574Q999421, 3EBI-702209,EBI-348482 I2D: score=3 
    ENSG00000223767Q999421, 3EBI-702209,EBI-348482 I2D: score=3 
    ENSG00000225452Q999421, 3EBI-702209,EBI-348482 I2D: score=3 
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    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0006928cellular component movement IEA--
    GO:0006936muscle contraction TAS--
    GO:0007010cytoskeleton organization IEA--
    GO:0007155cell adhesion NAS10840040

    Find genes that share ontologies with PXN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PXN (PAXI)

    Selected Novoseek inferred chemical compound relationships for PXN gene (see all 82)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 86.6 732 10554546 (9), 11695992 (6), 9230116 (6), 19917054 (6) (see all 99)
    phosphotyrosine 80.6 69 10318759 (3), 8809054 (3), 15554394 (3), 10625692 (2) (see all 47)
    cytochalasin d 76.5 19 11121866 (1), 7536689 (1), 7593197 (1), 11095944 (1) (see all 18)
    herbimycin a 64.9 2 11095944 (1), 17686951 (1)
    1-oleoyl-lyso-phosphatidic acid 60.4 4 9182707 (2), 7510708 (1)
    phenylarsine oxide 55.4 6 10438590 (1), 11839769 (1), 8809054 (1), 9160844 (1) (see all 5)
    phosphatidylinositol 52 12 9748296 (2), 9837978 (1), 17616673 (1), 18632638 (1) (see all 10)
    phalloidin 51.5 2 11581207 (1), 12827288 (1)
    genistein 51.2 5 8888312 (1), 11121866 (1), 10925297 (1), 9632700 (1) (see all 5)
    grgds 46.1 3 10441508 (1), 10954702 (1)



    Find genes that share compounds with PXN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PXN gene (4 alternative transcripts): 
    NM_001080855.2  NM_001243756.1  NM_002859.3  NM_025157.4  

    Unigene Cluster for PXN:

    Paxillin
    Hs.446336  [show with all ESTs]
    Unigene Representative Sequence: AK128712
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000458477(uc001txx.3) ENST00000228307(uc001txt.3) ENST00000424649(uc001txy.3)
    ENST00000536957 ENST00000323871(uc001txz.3) ENST00000538144 ENST00000550795
    ENST00000547983 ENST00000551327 ENST00000543331 ENST00000546532 ENST00000548912
    ENST00000552550 ENST00000440827 ENST00000547746 ENST00000540221 ENST00000550205
    ENST00000547772
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PXN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PXN (see all 42):
    hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-218 hsa-miR-3622b-3p hsa-miR-4280 hsa-miR-203 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidPXN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PXN
    Predesigned siRNA for gene silencing in human, mouse, rat PXN
    Clone
    Products:
         
    OriGene clones in human, mouse for PXN (see all 19)
    OriGene ORF clones in mouse, rat for PXN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PXN (NM_025157)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PXN
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PXN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PXN
      QuantiTect SYBR Green Assays in human, mouse, rat PXN
      QuantiFast Probe-based Assays in human, mouse, rat PXN
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12227) for PXN 

    Additional mRNA sequence: 

    AK026695.1 AK122964.1 AK128712.1 AK298057.1 AK299486.1 AK314204.1 BC003647.2 BC006840.1 
    BC010498.1 BC015217.1 BC052611.1 BC136787.1 BC136794.1 BC144410.1 BX648777.1 D86862.1 
    D86863.1 U14588.1 

    Selected DOTS entries (see all 34):

    DT.95239486  DT.101985119  DT.121112896  DT.91749764  DT.100879907  DT.100879909  DT.95239416  DT.95303914 
    DT.121113350  DT.121113187  DT.121113351  DT.91671802  DT.100837255  DT.102841487  DT.121112725  DT.121113065 
    DT.449204  DT.121113328  DT.99980927  DT.100879918  DT.121113388  DT.121113383  DT.100879910  DT.121113273 

    Selected AceView cDNA sequences (see all 515):

    BF222255 BX391817 BQ416695 BM677663 CB140461 BE871300 BM690056 BQ888939 
    T32707 AI453781 CD516260 BF346018 AI744239 CB160857 AW276466 BC052611 
    AW044517 CD367870 AI953815 AI301356 AI815236 BC010498 BC003647 BM969223 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PXN (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                                                                -     -           -                                             
    SP2:                                                                    -     -     -     -           -                                             
    SP3:                                                                    -     -     -     -     -                                                   
    SP4:                                                                    -     -     -     -     -     -                                             
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for PXN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PXN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTCAAAA
    PXN Expression
    About this image


    PXN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Condensate Cells Zeugopod
             Bone Marrow
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
    PXN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PXN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446336
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PXN: 
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PXN gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pxn1 , 5 paxillin1, 5 88.56(n)1
    93.45(a)1
      5 (56.10 cM)5
    193031  NM_133915.31  NP_598676.21 
     1155066765 
    chicken
    (Gallus gallus)
    Aves PXN1 paxillin 81.26(n)
    89.74(a)
      395832  NM_204984.1  NP_990315.1 
    lizard
    (Anolis carolinensis)
    Reptilia PXN6
    paxillin
    87(a)
    1 ↔ 1
    GL343338.1(430653-450808)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978262 paxillin 76.95(n)    AB027499.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb6312 Danio rerio cDNA clone IMAGE5915845, partial cds 77.19(n)    BC054700.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pax3 cytoskeletal anchoring cytoskeletal
    anchor protein
    70(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C28H8.63 LIM domains 54(a)   III(5962097-5964317)   --


    ENSEMBL Gene Tree for PXN (if available)
    TreeFam Gene Tree for PXN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PXN gene
    LIMS12  PDLIM72  LIMS3L2  FHL32  FHL52  LDB32  LPXN2  FHL12  
    ENSG000002572072  LIMS32  TGFB1I12  PDLIM52  FHL22  LIMS22  
    11 SIMAP similar genes for PXN using alignment to 11 protein entries:     PAXI_HUMAN (see all proteins):
    LPXN    TGFB1I1    CRIP1    LHx4    PDLIM5    LIMS1
    LIMS2    CRIP2    LMO1    LIMS3    LMO4

    Find genes that share paralogs with PXN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PXN (see all 918)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924162741,2
    --120440925(+) TTGTAC/TATGTA 4 -- ds50010--------
    rs1854324321,2
    --120441103(+) GGCAGA/GAGCAA 4 -- ds50010--------
    rs1386125311,2
    --120441208(+) TCCATC/TTGGTG 4 -- ds50010--------
    rs1174951811,2
    F--120441249(+) CTGCTG/AGGACC 4 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1426925341,2
    C--120441353(+) GCCAGC/GTTGGA 4 -- ut310--------
    rs1124759321,2
    F--120441390(+) AATCAG/AATTTT 4 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1473333401,2
    C--120441406(+) AACCAC/TTGACT 4 -- ut310--------
    rs1816014181,2
    --120441452(+) GGGAAC/GATCTA 4 -- ut310--------
    rs124233751,2
    C,F,H--120441519(+) ACCTTT/GGGAGG 4 -- ut31 ese38Minor allele frequency- G:0.01NS EA NA 800
    rs1498289721,2
    --120441531(+) GCTGGA/GCTGAC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for PXN (120648250 - 120703574 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PXN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905CNV Insertion18451855
    nsv832530CNV Loss17160897
    nsv899555CNV Loss21882294
    nsv519657CNV Loss19592680
    nsv899556CNV Gain21882294
    nsv7238OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PXN
    DNA2.0 Custom Variant and Variant Library Synthesis for PXN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602505    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PXN:
    Cancer

    Find genes that share disorders with PXN           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PXN gene (see all 42)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 2 47.7 2 18486129 (2)
    metastasis 40 27 12910696 (3), 17440071 (2), 18492274 (2), 20369478 (2) (see all 18)
    tumors 31.3 55 17319853 (4), 11759057 (4), 19353596 (3), 12198769 (3) (see all 28)
    glioblastoma 27.2 2 18813807 (1), 18504440 (1)
    cancer 24.2 23 15132756 (3), 17440071 (2), 18380937 (1), 18990162 (1) (see all 14)
    colon cancer 22.2 10 14667936 (2), 16855384 (2), 17982677 (1), 20127017 (1) (see all 8)
    breast carcinoma 20.3 4 17319853 (2), 16360410 (1), 11928806 (1)
    myeloid leukemia chronic 14.3 1 7493940 (1)
    carcinoma lewis lung 13.3 3 12198769 (2), 12856723 (1)
    breast cancer 12.1 21 17319853 (3), 10383144 (3), 20369478 (3), 17047043 (2) (see all 11)

    Genetic Association Database (GAD): PXN
    Human Genome Epidemiology (HuGE) Navigator: PXN (6 documents)

    Export disorders for PXN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PXN gene, integrated from 10 sources (see all 788):
    (articles sorted by number of sources associating them with PXN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. (PubMed id 7534286)1, 2, 3, 9 Salgia R.... Griffin J.D. (J. Biol. Chem. 1995)
    2. No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer. (PubMed id 19353596)1, 4, 9 Pallier K....Blons H. (Mol. Carcinog. 2009)
    3. A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. (PubMed id 10749932)1, 2, 9 Kondo A.... Sabe H. (Mol. Biol. Cell 2000)
    4. RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. (PubMed id 12861019)1, 2, 9 Didier C....Ronai Z. (Mol. Cell. Biol. 2003)
    5. Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins. (PubMed id 9054445)1, 2, 9 Mazaki Y.... Sabe H. (J. Biol. Chem. 1997)
    6. Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. (PubMed id 10938112)1, 2, 9 Zhao Z.-S.... Lim L. (Mol. Cell. Biol. 2000)
    7. Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2. (PubMed id 19358827)1, 2, 9 Lulo J.... Schlessinger J. (Biochem. Biophys. Res. Commun. 2009)
    8. Structural analysis of the interactions between paxillin LD motifs and alpha-parvin. (PubMed id 18940607)1, 2, 9 Lorenz S....Hoellerer M.K. (Structure 2008)
    9. The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. (PubMed id 18508764)1, 2, 9 Wang X....Qin J. (J. Biol. Chem. 2008)
    10. Paxillin and ponsin interact in nascent costameres of muscle cells. (PubMed id 17462669)1, 2, 9 Gehmlich K.... Furst D.O. (J. Mol. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5829 HGNC: 9718 AceView: PXN Ensembl:ENSG00000089159 euGenes: HUgn5829
    ECgene: PXN Kegg: 5829 H-InvDB: PXN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PXN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PXN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PXN gene:
    Search GeneIP for patents involving PXN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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