Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PXMP4 Gene

Aliases for PXMP4 Gene

  • Peroxisomal Membrane Protein 4 2 3 5
  • 24 KDa Peroxisomal Intrinsic Membrane Protein 2 3 4
  • Peroxisomal Membrane Protein 4, 24kDa 2 3
  • PMP24 3 4
  • Peroxisomal Membrane Protein 4 (24kD) 2

External Ids for PXMP4 Gene

Previous GeneCards Identifiers for PXMP4 Gene

  • GC20M032053
  • GC20M032962
  • GC20M033010
  • GC20M031758
  • GC20M032290
  • GC20M029076

Summaries for PXMP4 Gene

GeneCards Summary for PXMP4 Gene

PXMP4 (Peroxisomal Membrane Protein 4) is a Protein Coding gene. Diseases associated with PXMP4 include Prostate Adenocarcinoma. Among its related pathways are Peroxisome.

Gene Wiki entry for PXMP4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PXMP4 Gene

Genomics for PXMP4 Gene

Regulatory Elements for PXMP4 Gene

Enhancers for PXMP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G033553 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +165.4 165387 3.1 HDGF PKNOX1 FOXA2 ATF1 MLX SIN3A ZNF48 YY1 ELK1 NFYC CBFA2T2 C20orf144 ACTL10 NECAB3 PXMP4 ENSG00000229188 ZNF341 CDK5RAP1 CHMP4B BPIFB4
GH20G033687 1.4 Ensembl ENCODE 12.3 +30.8 30790 3.2 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF143 PXMP4 ENSG00000229188 ZNF341 ACTL10 C20orf144 CBFA2T2 SNTA1 E2F1 GC20M033707
GH20G033777 1.5 FANTOM5 Ensembl ENCODE 11.2 -58.7 -58715 2.8 HDGF HNRNPUL1 PKNOX1 FOXA2 ARID4B ZNF143 ZNF207 JUNB ZNF623 TBX21 CHMP4B ZNF341-AS1 ENSG00000229188 ZNF341 PXMP4 E2F1 BPIFA2 GC20M033791 RPL31P2
GH20G033824 1.5 Ensembl ENCODE dbSUPER 10.7 -107.5 -107513 6.5 HDGF PKNOX1 FOXA2 ATF1 FEZF1 TCF12 SLC30A9 NFYC JUNB KAT8 PXMP4 CHMP4B ENSG00000229188 ZNF341 ENSG00000272945 TPM3P2
GH20G033787 1.4 Ensembl ENCODE dbSUPER 11 -68.9 -68914 3.5 ELF3 NFIB SREBF2 SIN3A RAD21 BRCA1 RFX5 GATA2 ZNF366 RCOR1 ZNF341-AS1 CHMP4B ENSG00000229188 ZNF341 PXMP4 CBFA2T2 GC20M033791 PIR61258
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PXMP4 on UCSC Golden Path with GeneCards custom track

Promoters for PXMP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136297 30 1001 HDGF PKNOX1 CREB3L1 SIN3A YY1 ZNF143 ZNF207 FOS KLF13 SP3

Genomic Location for PXMP4 Gene

Chromosome:
20
Start:
33,702,744 bp from pter
End:
33,720,330 bp from pter
Size:
17,587 bases
Orientation:
Minus strand

Genomic View for PXMP4 Gene

Genes around PXMP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PXMP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PXMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXMP4 Gene

Proteins for PXMP4 Gene

  • Protein details for PXMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6I8-PXMP4_HUMAN
    Recommended name:
    Peroxisomal membrane protein 4
    Protein Accession:
    Q9Y6I8
    Secondary Accessions:
    • A2A2I7
    • Q9H0T4

    Protein attributes for PXMP4 Gene

    Size:
    212 amino acids
    Molecular mass:
    24264 Da
    Quaternary structure:
    • Interacts with PEX19.
    Miscellaneous:
    • Hypermethylation-mediated silencing of PXMP4 may be involved in prostate carcinogenesis. PXMP4 undergoes hypermethylation and silencing during the transition of prostate adenocarcinoma cells from androgen dependence to androgen independence.

    Alternative splice isoforms for PXMP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PXMP4 Gene

Post-translational modifications for PXMP4 Gene

  • Glycosylation at Asn57 and Asn206
  • Modification sites at PhosphoSitePlus

Other Protein References for PXMP4 Gene

No data available for DME Specific Peptides for PXMP4 Gene

Domains & Families for PXMP4 Gene

Protein Domains for PXMP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6I8

UniProtKB/Swiss-Prot:

PXMP4_HUMAN :
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
Family:
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
genes like me logo Genes that share domains with PXMP4: view

No data available for Gene Families for PXMP4 Gene

Function for PXMP4 Gene

Gene Ontology (GO) - Molecular Function for PXMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14709540
genes like me logo Genes that share ontologies with PXMP4: view
genes like me logo Genes that share phenotypes with PXMP4: view

Animal Model Products

CRISPR Products

miRNA for PXMP4 Gene

miRTarBase miRNAs that target PXMP4

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PXMP4 Gene

Localization for PXMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXMP4 Gene

Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PXMP4 gene
Compartment Confidence
peroxisome 5
mitochondrion 2
nucleus 2
plasma membrane 1
extracellular 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PXMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA --
GO:0005778 peroxisomal membrane ISS 10366717
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PXMP4: view

Pathways & Interactions for PXMP4 Gene

SuperPathways for PXMP4 Gene

SuperPathway Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with PXMP4: view

Pathways by source for PXMP4 Gene

1 KEGG pathway for PXMP4 Gene

Interacting Proteins for PXMP4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000386385%0d%0a9606.ENSP00000357051%0d%0a9606.ENSP00000359233%0d%0a
Selected Interacting proteins: Q9Y6I8-PXMP4_HUMAN ENSP00000386385 for PXMP4 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PXMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PXMP4: view

No data available for SIGNOR curated interactions for PXMP4 Gene

Drugs & Compounds for PXMP4 Gene

No Compound Related Data Available

Transcripts for PXMP4 Gene

Unigene Clusters for PXMP4 Gene

Peroxisomal membrane protein 4, 24kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PXMP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for PXMP4 Gene

GeneLoc Exon Structure for
PXMP4
ECgene alternative splicing isoforms for
PXMP4

Expression for PXMP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PXMP4 Gene

Protein differential expression in normal tissues from HIPED for PXMP4 Gene

This gene is overexpressed in Bone (28.1), Fetal ovary (13.8), and Lung (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PXMP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of PXMP4 Gene:

PXMP4

SOURCE GeneReport for Unigene cluster for PXMP4 Gene:

Hs.654857

mRNA Expression by UniProt/SwissProt for PXMP4 Gene:

Q9Y6I8-PXMP4_HUMAN
Tissue specificity: Expressed in normal prostate epithelial cells, and androgen-sensitive prostate adenocarcinoma cells. Not expressed in androgen-insensitive prostate adenocarcinoma cells.

Evidence on tissue expression from TISSUES for PXMP4 Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with PXMP4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PXMP4 Gene

Orthologs for PXMP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PXMP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PXMP4 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia PXMP4 34 35
  • 86.01 (n)
dog
(Canis familiaris)
Mammalia PXMP4 34 35
  • 85.38 (n)
rat
(Rattus norvegicus)
Mammalia Pxmp4 34
  • 83.96 (n)
mouse
(Mus musculus)
Mammalia Pxmp4 34 16 35
  • 83.49 (n)
oppossum
(Monodelphis domestica)
Mammalia PXMP4 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PXMP4 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves PXMP4 34 35
  • 72.73 (n)
lizard
(Anolis carolinensis)
Reptilia PXMP4 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pxmp4 34
  • 69.03 (n)
Str.14175 34
zebrafish
(Danio rerio)
Actinopterygii PXMP4 35
  • 73 (a)
OneToOne
wu:fe02h09 34
  • 69.7 (n)
Dr.27801 34
worm
(Caenorhabditis elegans)
Secernentea F18F11.1 36 34 35
  • 53.2 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00828 34
  • 51.58 (n)
Species where no ortholog for PXMP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PXMP4 Gene

ENSEMBL:
Gene Tree for PXMP4 (if available)
TreeFam:
Gene Tree for PXMP4 (if available)

Paralogs for PXMP4 Gene

No data available for Paralogs for PXMP4 Gene

Variants for PXMP4 Gene

Sequence variations from dbSNP and Humsavar for PXMP4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000097820 -- 33,706,079(+) TGCCA(C/T)CATGC utr-variant-3-prime
rs1000188738 -- 33,703,129(+) CGGTA(G/T)CGGAG utr-variant-3-prime
rs1000293581 -- 33,707,807(+) CGAGG(A/G)CTGCA reference, missense, utr-variant-3-prime
rs1000341684 -- 33,722,269(+) CGGGC(A/G)GATCA upstream-variant-2KB
rs1000370602 -- 33,709,464(+) GGTCA(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PXMP4 Gene

Variant ID Type Subtype PubMed ID
esv995879 CNV deletion 20482838
nsv1065189 CNV loss 25217958
nsv1143984 CNV deletion 24896259
nsv3353 CNV deletion 18451855
nsv828714 CNV loss 20364138
nsv833961 CNV loss 17160897

Variation tolerance for PXMP4 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PXMP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PXMP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXMP4 Gene

Disorders for PXMP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PXMP4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate adenocarcinoma
  • adenocarcinoma of prostate
- elite association - COSMIC cancer census association via MalaCards
Search PXMP4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PXMP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PXMP4
genes like me logo Genes that share disorders with PXMP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PXMP4 Gene

Publications for PXMP4 Gene

  1. Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes. (PMID: 10366717) Reguenga C. … Azevedo J.E. (Biochim. Biophys. Acta 1999) 2 3 4 64
  2. Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. (PMID: 20054818) Zhang X. … Ho S.M. (Prostate 2010) 4 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. (PMID: 14709540) Jones J.M. … Gould S.J. (J. Cell Biol. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PXMP4 Gene

Sources for PXMP4 Gene

Content
Loading form....