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Aliases for PXMP4 Gene

Aliases for PXMP4 Gene

  • Peroxisomal Membrane Protein 4 2 3 5
  • 24 KDa Peroxisomal Intrinsic Membrane Protein 2 3 4
  • Peroxisomal Membrane Protein 4, 24kDa 2 3
  • PMP24 3 4
  • Peroxisomal Membrane Protein 4 (24kD) 2

External Ids for PXMP4 Gene

Previous GeneCards Identifiers for PXMP4 Gene

  • GC20M032053
  • GC20M032962
  • GC20M033010
  • GC20M031758
  • GC20M032290
  • GC20M029076

Summaries for PXMP4 Gene

GeneCards Summary for PXMP4 Gene

PXMP4 (Peroxisomal Membrane Protein 4) is a Protein Coding gene. Among its related pathways are Peroxisome.

Gene Wiki entry for PXMP4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PXMP4 Gene

Genomics for PXMP4 Gene

Regulatory Elements for PXMP4 Gene

Promoters for PXMP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PXMP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PXMP4 Gene

Chromosome:
20
Start:
33,702,744 bp from pter
End:
33,720,330 bp from pter
Size:
17,587 bases
Orientation:
Minus strand

Genomic View for PXMP4 Gene

Genes around PXMP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PXMP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PXMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXMP4 Gene

Proteins for PXMP4 Gene

  • Protein details for PXMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6I8-PXMP4_HUMAN
    Recommended name:
    Peroxisomal membrane protein 4
    Protein Accession:
    Q9Y6I8
    Secondary Accessions:
    • A2A2I7
    • Q9H0T4

    Protein attributes for PXMP4 Gene

    Size:
    212 amino acids
    Molecular mass:
    24264 Da
    Quaternary structure:
    • Interacts with PEX19.
    Miscellaneous:
    • Hypermethylation-mediated silencing of PXMP4 may be involved in prostate carcinogenesis. PXMP4 undergoes hypermethylation and silencing during the transition of prostate adenocarcinoma cells from androgen dependence to androgen independence.

    Alternative splice isoforms for PXMP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PXMP4 Gene

Proteomics data for PXMP4 Gene at MOPED

Post-translational modifications for PXMP4 Gene

  • Glycosylation at Asn 57 and Asn 206
  • Modification sites at PhosphoSitePlus

Other Protein References for PXMP4 Gene

No data available for DME Specific Peptides for PXMP4 Gene

Domains & Families for PXMP4 Gene

Protein Domains for PXMP4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y6I8

UniProtKB/Swiss-Prot:

PXMP4_HUMAN :
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
Family:
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
genes like me logo Genes that share domains with PXMP4: view

No data available for Gene Families for PXMP4 Gene

Function for PXMP4 Gene

genes like me logo Genes that share phenotypes with PXMP4: view

Animal Model Products

miRNA for PXMP4 Gene

miRTarBase miRNAs that target PXMP4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PXMP4 Gene

Localization for PXMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXMP4 Gene

Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PXMP4 Gene COMPARTMENTS Subcellular localization image for PXMP4 gene
Compartment Confidence
peroxisome 5
mitochondrion 2
nucleus 2
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PXMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PXMP4: view

Pathways & Interactions for PXMP4 Gene

SuperPathways for PXMP4 Gene

Superpath Contained pathways
1 Peroxisome
genes like me logo Genes that share pathways with PXMP4: view

Pathways by source for PXMP4 Gene

1 KEGG pathway for PXMP4 Gene

Interacting Proteins for PXMP4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000386385%0d%0a9606.ENSP00000357051%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9Y6I8-PXMP4_HUMAN ENSP00000386385 for PXMP4 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for PXMP4 Gene

None

No data available for SIGNOR curated interactions for PXMP4 Gene

Drugs & Compounds for PXMP4 Gene

No Compound Related Data Available

Transcripts for PXMP4 Gene

Unigene Clusters for PXMP4 Gene

Peroxisomal membrane protein 4, 24kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PXMP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for PXMP4 Gene

GeneLoc Exon Structure for
PXMP4
ECgene alternative splicing isoforms for
PXMP4

Expression for PXMP4 Gene

mRNA expression in normal human tissues for PXMP4 Gene

Protein differential expression in normal tissues from HIPED for PXMP4 Gene

This gene is overexpressed in Bone (28.1), Fetal ovary (13.8), and Lung (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PXMP4 Gene



SOURCE GeneReport for Unigene cluster for PXMP4 Gene Hs.654857

mRNA Expression by UniProt/SwissProt for PXMP4 Gene

Q9Y6I8-PXMP4_HUMAN
Tissue specificity: Expressed in normal prostate epithelial cells, and androgen-sensitive prostate adenocarcinoma cells. Not expressed in androgen-insensitive prostate adenocarcinoma cells.
genes like me logo Genes that share expression patterns with PXMP4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for PXMP4 Gene

Orthologs for PXMP4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PXMP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PXMP4 35
  • 86.01 (n)
  • 82.55 (a)
PXMP4 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PXMP4 35
  • 85.38 (n)
  • 84.91 (a)
PXMP4 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pxmp4 35
  • 83.49 (n)
  • 80.66 (a)
Pxmp4 16
Pxmp4 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PXMP4 35
  • 99.84 (n)
  • 99.53 (a)
PXMP4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pxmp4 35
  • 83.96 (n)
  • 82.55 (a)
oppossum
(Monodelphis domestica)
Mammalia PXMP4 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PXMP4 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves PXMP4 35
  • 72.73 (n)
  • 78.95 (a)
PXMP4 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PXMP4 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pxmp4 35
  • 69.03 (n)
  • 73.58 (a)
Str.14175 35
zebrafish
(Danio rerio)
Actinopterygii Dr.27801 35
wu:fe02h09 35
  • 69.7 (n)
  • 73.21 (a)
PXMP4 36
  • 73 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F18F11.1 37
  • 55 (a)
F18F11.1 35
  • 53.2 (n)
  • 55.44 (a)
F18F11.1 36
  • 51 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00828 35
  • 51.58 (n)
  • 45.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for PXMP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PXMP4 Gene

ENSEMBL:
Gene Tree for PXMP4 (if available)
TreeFam:
Gene Tree for PXMP4 (if available)

Paralogs for PXMP4 Gene

No data available for Paralogs for PXMP4 Gene

Variants for PXMP4 Gene

Sequence variations from dbSNP and Humsavar for PXMP4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs910397 - 33,707,735(+) ATAGA(C/T)GAGGA reference, missense, utr-variant-3-prime
rs959144 -- 33,706,778(+) caaaa(C/T)ataca utr-variant-3-prime
rs1060683 -- 33,707,587(-) GGTTC(C/T)GTTTG utr-variant-3-prime
rs1074683 -- 33,716,847(+) TGTAC(C/G)TATTC intron-variant
rs2377925 -- 33,708,487(+) GGCCT(G/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PXMP4 Gene

Variant ID Type Subtype PubMed ID
nsv833961 CNV Loss 17160897
dgv4564n71 CNV Loss 21882294
esv995879 CNV Deletion 20482838
nsv3353 CNV Loss 18451855
nsv912848 CNV Loss 21882294
nsv828714 CNV Loss 20364138

Variation tolerance for PXMP4 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PXMP4 Gene

HapMap Linkage Disequilibrium report
PXMP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXMP4 Gene

Disorders for PXMP4 Gene

Relevant External Links for PXMP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PXMP4

No disorders were found for PXMP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PXMP4 Gene

Publications for PXMP4 Gene

  1. Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes. (PMID: 10366717) Reguenga C. … Azevedo J.E. (Biochim. Biophys. Acta 1999) 2 3 4 67
  2. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 3
  3. Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. (PMID: 20054818) Zhang X. … Ho S.M. (Prostate 2010) 23
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for PXMP4 Gene

Sources for PXMP4 Gene

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