Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PXMP2 Gene

protein-coding   GIFtS: 51
GCID: GC12P133264

peroxisomal membrane protein 2, 22kDa

(Previous name: peroxisomal membrane protein 2 (22kD) )
 Explore 4 diseases affiliated with
PXMP2 via our new
 Human Malady Compendium 
Biological research products
for PXMP2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Peroxisomal Membrane Protein 2, 22kDa1 2
PMP221 2 3
22 KDa Peroxisomal Membrane Protein2 3
Peroxisomal Membrane Protein 2 (22kD)1
Peroxisomal Membrane Protein 22

External Ids:    HGNC: 97161   Entrez Gene: 58272   Ensembl: ENSG000001768947   UniProtKB: Q9NR773   

Export aliases for PXMP2 gene to outside databases

Previous GC identifers: GC00U990301 GC12M132864 GC12P132889 GC12P131503 GC12P131874 GC12P131774


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PXMP2_HUMAN, Q9NR77
Function: Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the
peroxisomal membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_024477.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PXMP2 gene promoter:
         Pbx1a   AML1a   GATA-3   ATF-2   Evi-1   GATA-2   AREB6   MZF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPXMP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PXMP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PXMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24

PXMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PXMP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P133264:  view genomic region     (about GC identifiers)

Start:
133,264,192 bp from pter      End:
133,297,276 bp from pter
Size:
33,085 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PXMP2_HUMAN, Q9NR77 (See protein sequence)
Recommended Name: Peroxisomal membrane protein 2  
Size: 195 amino acids; 22253 Da
Subunit: Interacts with PEX19 and SIVA1
Subcellular location: Peroxisome membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for PXMP2: NX_Q9NR77

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NR77

  • PXMP2 Protein expression data from MOPED and PaxDb:    About this image 
    PXMP2 Protein Expression
    REFSEQ proteins: NP_061133.1  
    ENSEMBL proteins: 
     ENSP00000321271   ENSP00000446049   ENSP00000444486   ENSP00000398708   ENSP00000445782  

    Human Recombinant Protein Products for PXMP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PXMP2
    OriGene Protein Over-expression Lysate: PXMP2
    OriGene Custom Protein Services for PXMP2 
    GenScript Custom Purified and Recombinant Proteins Services for PXMP2
    Novus Biologicals PXMP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PXMP2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA8624723
    GO:0005739mitochondrion IEA--
    GO:0005778peroxisomal membrane IDA11590176
    GO:0016021integral to membrane IEA--
    GO:0043234protein complex IDA18174172

    PXMP2 for ontologies           About GeneDecksing



    PXMP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PXMP2 
    GenScript Custom Superior Antibodies Services for PXMP2
    Novus Biologicals PXMP2 Antibody
    Abcam antibodies for PXMP2 
    Uscn Antibodies for PXMP2
    ThermoFisher Antibodies for PXMP2

    Assay Products for PXMP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PXMP2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PXMP2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PXMP2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007248 Mpv17_PMP22

    Graphical View of Domain Structure for InterPro Entry Q9NR77

    ProtoNet protein and cluster: Q9NR77

    1 Blocks protein family: IPB007248 Mpv17/PMP22

    UniProtKB/Swiss-Prot: PXMP2_HUMAN, Q9NR77
    Similarity: Belongs to the peroxisomal membrane protein PXMP2/4 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PXMP2_HUMAN, Q9NR77
    Function: Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the
    peroxisomal membrane

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16683188
         
    PXMP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PXMP2:
     Elongated cells with protrusio  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pxmp2):
     endocrine/exocrine gland  homeostasis/metabolism  integument  liver/biliary system  renal/urinary system 
     reproductive system 

    PXMP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PXMP2 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: PXMP2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PXMP2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PXMP2
    SwitchGear 3'UTR luciferase reporter plasmidPXMP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PXMP2 (see all 7)
    OriGene shRNA RFP: PXMP2
    OriGene siRNA: PXMP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PXMP2
    Sirion Biotech Custom design and validation of potent shRNA sequences against PXMP2 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PXMP2
    Sirion Biotech Customized adenovirus for overexpression of PXMP2 
    Sirion Biotech Customized adenovirus for potent knockdown of PXMP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PXMP2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PXMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PXMP2 (NM_018663)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PXMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PXMP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PXMP2
    Search LifeMap BioReagents cell lines for PXMP2
    Sirion Biotech Customized stable knockdown cell line services for PXMP2 
    Sirion Biotech Customized inducible knockdown cell line services for PXMP2
    Sirion Biotech Customized stable overexpressing cell line services for PXMP2
    Sirion Biotech Customized inducible overexpressing cell line services for PXMP2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXMP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Peroxisome
    Peroxisome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for PXMP2):
        Peroxisome


    PXMP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PXMP2

    2 Interacting proteins for PXMP2 (Q9NR771, 2, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIVA1O153041, 3EBI-1392944,EBI-520756 I2D: score=2 
    PEX19P408552, 3MINT-8089433 I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    PXMP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PXMP2
    Search CenterWatch for drugs/clinical trials and news about PXMP2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PXMP2 gene: 
    NM_018663.1  

    Unigene Cluster for PXMP2:

    Peroxisomal membrane protein 2, 22kDa
    Hs.430299  [show with all ESTs]
    Unigene Representative Sequence: BM454192
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317479(uc001ukt.3) ENST00000543589 ENST00000539093 ENST00000428960
    ENST00000454379 ENST00000545677

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: PXMP2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PXMP2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PXMP2
    SwitchGear 3'UTR luciferase reporter plasmidPXMP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PXMP2 (see all 7)
    OriGene shRNA RFP: PXMP2
    OriGene siRNA: PXMP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PXMP2
    Sirion Biotech Custom design and validation of potent shRNA sequences against PXMP2 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PXMP2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PXMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PXMP2 (NM_018663)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PXMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PXMP2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PXMP2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PXMP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PXMP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PXMP2

    Additional cDNA sequence: 

    AF250136.1 AY044439.1 BC009836.1 BC073997.1 

    5 DOTS entries:

    DT.412840  DT.91759817  DT.92005633  DT.100008697  DT.100019760 

    24/81 AceView cDNA sequences (see all 81):

    AW445130 BM671530 BQ440491 BX116473 BC073997 BU195441 AI627671 BI963751 
    BG170017 CA430320 NM_018663 AY044439 BG741408 BQ945909 BM767070 BM704325 
    BF197383 BE393339 AI869066 BC009836 BF739892 BG565371 AA725609 CB046071 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PXMP2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                    -                             -                     
    SP2:                    -                                                   
    SP3:                    -                             -                     
    SP4:                                                  -                     


    ECgene alternative splicing isoforms for PXMP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PXMP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACTTTCTGG
    PXMP2 Expression
    About this image
    See PXMP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PXMP2

    SOURCE GeneReport for Unigene cluster: Hs.430299
        SABiosciences Expression via Pathway-Focused PCR Array including PXMP2: 

              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PXMP2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PXMP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PXMP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PXMP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXMP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PXMP2 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.59812 Transcribed sequence with weak similarity to protein more 73.74(n)    137722054 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:925991 zgc:92599 60.37(n)
    58.33(a)
      447868  NM_001004607.1  NP_001004607.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79701 CG7970 46.79(n)
    28.57(a)
      38205  NM_139384.3  NP_647641.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G197501 protein Mpv17 46.54(n)
    34.76(a)
      832095  NM_121980.3  NP_197476.1 
    rice
    (Oryza sativa)
    Liliopsida --
    --
    Mpv17 / PMP22 family domain containing protein, ex...
    Mpv17 / PMP22 family domain containing protein, ex...
    26(a)
    24(a)
    1 ↔ many
    1 ↔ many
    8(28385439-28388371)
    2(7066390-7069494)


    ENSEMBL Gene Tree for PXMP2 (if available)
    TreeFam Gene Tree for PXMP2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PXMP2 gene
    ENSG000002611302  MPV172  MPV17L2  MPV17L22  
    1 SIMAP similar gene for PXMP2 using alignment to 5 protein entries:     PXMP2_HUMAN (see all proteins):
    MPV17

    PXMP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/474 NCBI SNPs in PXMP2 are shown (see all 474    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915795241,2
    --133265950(+) GGCTGC/TGTAAA 1 -- int10--------
    rs1817104471,2
    --133265996(+) GCAGGA/GCAAAG 1 -- int10--------
    rs118380971,2
    C,F,H--133266175(+) AGGTCC/TGTGCT 1 -- int111Minor allele frequency- T:0.05NS EA NA CSA WA 1212
    rs1173202951,2
    F--133266203(+) TAGTCC/TAGAGA 1 -- int11Minor allele frequency- T:0.03EA 120
    rs744646881,2
    F--133266212(+) GAGCTT/GCTCAG 1 -- int11Minor allele frequency- G:0.09WA 118
    rs780349121,2
    C--133266295(+) GATAAC/TTGTAG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1457509431,2
    --133266409(+) GCATTC/GCGTGG 1 -- int10--------
    rs1870746601,2
    --133266560(+) TTGCCC/TGTTCA 1 -- int10--------
    rs769943631,2
    --133266655(+) ACTTGT/CCCTTA 1 -- int12Minor allele frequency- C:0.10CSA WA 120
    rs1919077671,2
    --133266737(+) TTCCTA/GCCCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PXMP2 (133264192 - 133297276 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PXMP2
         2 CNVs: 71663 71662

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PXMP2
    DNA2.0 Custom Variant and Variant Library Synthesis for PXMP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PXMP2 for disorders           About GeneDecksing

    4 diseases for PXMP2:    About MalaCards
    parkinson's disease    colon carcinoma    ischemia    carcinoma


    Export disorders for PXMP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PXMP2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with PXMP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes. (PubMed id 11590176)1, 2, 3, 9 Brosius U.... Gaertner J. (2002)
    2. The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22. (PubMed id 16683188)1, 2 Nestler M....Munder T. (2006)
    3. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. (PubMed id 10704444)1, 2 Sacksteder K.A.... Gould S.J. (2000)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a critical residue for the interaction. (PubMed id 18174172)1 Sato Y....Kato H. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    10. Developmental immunohistochemistry of the 22 kDa peroxisomal membrane protein in the human brain. (PubMed id 8624723)1 Miyawaki T....Takashima S. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5827 HGNC: 9716 AceView: PXMP2 Ensembl:ENSG00000176894 euGenes: HUgn5827
    ECgene: PXMP2 Kegg: 5827 H-InvDB: PXMP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PXMP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PXMP2 gene:
    Search GeneIP for patents involving PXMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PXMP2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PXMP2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PXMP2  
     OriGene Protein Over-expression Lysate for PXMP2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PXMP2   OriGene 3'-UTR Clone for PXMP2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PXMP2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PXMP2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for PXMP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PXMP2   OriGene Custom Protein Services for PXMP2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PXMP2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PXMP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PXMP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PXMP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PXMP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PXMP2
     GenScript Custom Purified and Recombinant Proteins Services for PXMP2 GenScript cDNA clones with any tag delivered in your preferred vector for PXMP2
     GenScript Custom Assay Services for PXMP2 GenScript Custom Superior Antibodies Services for PXMP2
     GenScript Custom overexpressing Cell Line Services for PXMP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PXMP2 promoter
     Search Chromatin IP Primers for PXMP2
     RT2 qPCR Primer Assay in human, mouse, rat PXMP2
     Search GNC Networks for PXMP2
     SABiosciences PCR Arrays including human, mouse, rat PXMP2
     Search Tocris compounds for PXMP2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PXMP2 antibodies
     PXMP2 lysates
     Antibodies for PXMP2
     See all of Abcam's Antibodies, Kits and Proteins for PXMP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PXMP2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PXMP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXMP2
     SwitchGear 3'UTR luciferase reporter plasmids for PXMP2
     SwitchGear Promoter luciferase reporter plasmids for PXMP2
     ThermoFisher Antibodies for PXMP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PXMP2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PXMP2
    Sirion Biotech Customized:
     stable knockdown cell line services for PXMP2
     inducible knockdown cell line services for PXMP2
     design and validation of potent shRNA sequences against PXMP2
     adenovirus for potent knockdown of PXMP2
     adenovirus for overexpression of PXMP2
     stable overexpressing cell line services for PXMP2
     inducible overexpressing cell line services for PXMP2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PXMP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4