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Aliases for PXMP2 Gene

Aliases for PXMP2 Gene

  • Peroxisomal Membrane Protein 2 2 3 5
  • Peroxisomal Membrane Protein 2, 22kDa 2 3
  • 22 KDa Peroxisomal Membrane Protein 3 4
  • PMP22 3 4
  • Peroxisomal Membrane Protein 2 (22kD) 2

External Ids for PXMP2 Gene

Previous GeneCards Identifiers for PXMP2 Gene

  • GC00U990301
  • GC12M132864
  • GC12P132889
  • GC12P131503
  • GC12P131874
  • GC12P131774
  • GC12P133264

Summaries for PXMP2 Gene

GeneCards Summary for PXMP2 Gene

PXMP2 (Peroxisomal Membrane Protein 2) is a Protein Coding gene. Among its related pathways are Peroxisome and a6b1 and a6b4 Integrin signaling. An important paralog of this gene is MPV17L2.

UniProtKB/Swiss-Prot for PXMP2 Gene

  • Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PXMP2 Gene

Genomics for PXMP2 Gene

Regulatory Elements for PXMP2 Gene

Promoters for PXMP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PXMP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PXMP2 Gene

Chromosome:
12
Start:
132,687,606 bp from pter
End:
132,704,991 bp from pter
Size:
17,386 bases
Orientation:
Plus strand

Genomic View for PXMP2 Gene

Genes around PXMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PXMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PXMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXMP2 Gene

Proteins for PXMP2 Gene

  • Protein details for PXMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR77-PXMP2_HUMAN
    Recommended name:
    Peroxisomal membrane protein 2
    Protein Accession:
    Q9NR77

    Protein attributes for PXMP2 Gene

    Size:
    195 amino acids
    Molecular mass:
    22253 Da
    Quaternary structure:
    • Interacts with PEX19 and SIVA1.

neXtProt entry for PXMP2 Gene

Proteomics data for PXMP2 Gene at MOPED

Post-translational modifications for PXMP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PXMP2 Gene

No data available for DME Specific Peptides for PXMP2 Gene

Domains & Families for PXMP2 Gene

Protein Domains for PXMP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PXMP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NR77

UniProtKB/Swiss-Prot:

PXMP2_HUMAN :
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
Family:
  • Belongs to the peroxisomal membrane protein PXMP2/4 family.
genes like me logo Genes that share domains with PXMP2: view

No data available for Gene Families for PXMP2 Gene

Function for PXMP2 Gene

Molecular function for PXMP2 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
genes like me logo Genes that share phenotypes with PXMP2: view

Animal Models for PXMP2 Gene

MGI Knock Outs for PXMP2:

Animal Model Products

miRNA for PXMP2 Gene

miRTarBase miRNAs that target PXMP2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PXMP2 Gene

Localization for PXMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXMP2 Gene

Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PXMP2 Gene COMPARTMENTS Subcellular localization image for PXMP2 gene
Compartment Confidence
peroxisome 5
mitochondrion 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PXMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0043234 protein complex IDA 18174172
genes like me logo Genes that share ontologies with PXMP2: view

Pathways & Interactions for PXMP2 Gene

genes like me logo Genes that share pathways with PXMP2: view

Pathways by source for PXMP2 Gene

2 BioSystems pathways for PXMP2 Gene
1 KEGG pathway for PXMP2 Gene

Gene Ontology (GO) - Biological Process for PXMP2 Gene

None

No data available for SIGNOR curated interactions for PXMP2 Gene

Drugs & Compounds for PXMP2 Gene

No Compound Related Data Available

Transcripts for PXMP2 Gene

Unigene Clusters for PXMP2 Gene

Peroxisomal membrane protein 2, 22kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PXMP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for PXMP2 Gene

GeneLoc Exon Structure for
PXMP2
ECgene alternative splicing isoforms for
PXMP2

Expression for PXMP2 Gene

mRNA expression in normal human tissues for PXMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PXMP2 Gene

This gene is overexpressed in Liver (x10.0).

Protein differential expression in normal tissues from HIPED for PXMP2 Gene

This gene is overexpressed in Liver (28.8) and Gallbladder (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PXMP2 Gene



SOURCE GeneReport for Unigene cluster for PXMP2 Gene Hs.430299

genes like me logo Genes that share expression patterns with PXMP2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PXMP2 Gene

Orthologs for PXMP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PXMP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PXMP2 35
  • 83.93 (n)
  • 84.1 (a)
PXMP2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PXMP2 35
  • 85.59 (n)
  • 83.23 (a)
PXMP2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pxmp2 35
  • 79.97 (n)
  • 75.65 (a)
Pxmp2 16
Pxmp2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pxmp2 35
  • 80.76 (n)
  • 77.32 (a)
oppossum
(Monodelphis domestica)
Mammalia PXMP2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PXMP2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pxmp2 35
  • 62.57 (n)
  • 61.4 (a)
Str.5981 35
zebrafish
(Danio rerio)
Actinopterygii pxmp2 35
  • 58.6 (n)
  • 57.37 (a)
pxmp2 36
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6157 35
fruit fly
(Drosophila melanogaster)
Insecta CG7970 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SYM1 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19750 35
  • 46.75 (n)
  • 34.76 (a)
Species with no ortholog for PXMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PXMP2 Gene

ENSEMBL:
Gene Tree for PXMP2 (if available)
TreeFam:
Gene Tree for PXMP2 (if available)

Paralogs for PXMP2 Gene

Paralogs for PXMP2 Gene

(1) SIMAP similar genes for PXMP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PXMP2: view

Variants for PXMP2 Gene

Sequence variations from dbSNP and Humsavar for PXMP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10007 -- 132,704,876(-) GGCAG(C/T)GACTG utr-variant-3-prime
rs15720 -- 132,704,878(-) AAGGC(A/G)GTGAC utr-variant-3-prime
rs1129783 -- 132,704,958(+) GGATC(A/C)CAATA utr-variant-3-prime
rs4077415 -- 132,700,924(+) AGGAA(G/T)TGACA intron-variant
rs4883610 -- 132,701,489(-) ACTAC(A/C)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PXMP2 Gene

Variant ID Type Subtype PubMed ID
dgv1534n71 CNV Loss 21882294
esv2422284 CNV Deletion 17116639
nsv899827 CNV Gain 21882294
nsv512304 CNV Loss 21212237
esv24887 CNV Gain+Loss 19812545
esv25236 CNV Gain 19812545
nsv820594 CNV Deletion 20802225
nsv512305 CNV Loss 21212237
esv2747033 CNV Deletion 23290073
esv2747034 CNV Deletion 23290073

Variation tolerance for PXMP2 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PXMP2 Gene

HapMap Linkage Disequilibrium report
PXMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXMP2 Gene

Disorders for PXMP2 Gene

Relevant External Links for PXMP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PXMP2

No disorders were found for PXMP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PXMP2 Gene

Publications for PXMP2 Gene

  1. Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes. (PMID: 11590176) Brosius U. … Gaertner J. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3
  5. Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p. (PMID: 21102411) Sato Y. … Kato H. (EMBO J. 2010) 3

Products for PXMP2 Gene

Sources for PXMP2 Gene

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