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PXK Gene

protein-coding   GIFtS: 54
GCID: GC03P058318

PX Domain Containing Serine/Threonine Kinase

  See PXK-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PX Domain Containing Serine/Threonine Kinase1 2     PX Ser/Thr Kinase V22
MONaKA2 3     PX Serine/Threonine Kinase2
Modulator Of Na,K-ATPase Long Form2     Modulator Of Na,K-ATPase3
PX Domain-Containing Protein Kinase-Like Protein2     MONAKA5

External Ids:    HGNC: 233261   Entrez Gene: 548992   Ensembl: ENSG000001682977   OMIM: 6114505   UniProtKB: Q7Z7A43   

Export aliases for PXK gene to outside databases

Previous GC identifers: GC03P058173 GC03P058275 GC03P058293


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PXK Gene:
This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the
ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be
associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for PXK Gene:
PXK (PX domain containing serine/threonine kinase) is a protein-coding gene. Diseases associated with PXK include sle susceptibility, and systemic lupus erythematosus. GO annotations related to this gene include protein kinase activity and nucleotide binding.

UniProtKB/Swiss-Prot: PXK_HUMAN, Q7Z7A4
Function: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the
regulation of electrical excitability and synaptic transmission. May not display kinase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PXK gene promoter:
         RP58   NF-YA   Meis-1b   NF-YB   CBF-A   CBF-B   Meis-1a   CP1A   NF-Y   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPXK promoter sequence
   Search Chromatin IP Primers for PXK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PXK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p21.2

PXK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PXK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P058318:  view genomic region     (about GC identifiers)

Start:
58,318,607 bp from pter      End:
58,411,748 bp from pter
Size:
93,142 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PXK_HUMAN, Q7Z7A4 (See protein sequence)
Recommended Name: PX domain-containing protein kinase-like protein  
Size: 578 amino acids; 64950 Da
Sequence caution: Sequence=AAH14479.1; Type=Erroneous termination; Positions=451; Note=Translated as Gly;
Sequence=BAA91097.1; Type=Frameshift; Positions=569; Sequence=BAD18536.1; Type=Frameshift; Positions=510;
Sequence=BAD92925.1; Type=Frameshift; Positions=147;
Secondary accessions: Q3BCH4 Q3BCH5 Q3BCH6 Q3BDW1 Q45L83 Q59EX3 Q6PK17 Q6ZN39 Q96CA3 Q96R07
Q9NXB8
Alternative splicing: 7 isoforms:  Q7Z7A4-1   Q7Z7A4-2   Q7Z7A4-3   Q7Z7A4-4   Q7Z7A4-5   Q7Z7A4-6   Q7Z7A4-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PXK: NX_Q7Z7A4

Explore proteomics data for PXK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys406
  • Modification sites at PhosphoSitePlus

  • See PXK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001276024.1  NP_001276025.1  NP_001276027.1  NP_001276028.1  NP_001276029.1  NP_001276030.1  NP_060241.2  

    ENSEMBL proteins: 
     ENSP00000348472   ENSP00000417167   ENSP00000417903   ENSP00000373221   ENSP00000417915  
     ENSP00000419049   ENSP00000420403   ENSP00000418831   ENSP00000418202   ENSP00000476179  
     ENSP00000418376   ENSP00000418836   ENSP00000305045   ENSP00000373222   ENSP00000438356  

    PXK Human Recombinant Protein Products:

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    Novus Biologicals PXK Lysates
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: PX domain containing serine/threonine kinase
    Slob family

    5 InterPro protein domains:
     IPR001683 Phox
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR028298 PXK
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z7A4

    ProtoNet protein and cluster: Q7Z7A4

    2 Blocks protein domains:
    IPB001683 Phox-like
    IPB003124 Actin-binding WH2


    UniProtKB/Swiss-Prot: PXK_HUMAN, Q7Z7A4
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 WH2 domain


    Find genes that share domains with PXK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PXK_HUMAN, Q7Z7A4
    Function: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the
    regulation of electrical excitability and synaptic transmission. May not display kinase activity

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166NOT nucleotide binding NAS16142408
    GO:0003779actin binding IEA--
    GO:0004672NOT protein kinase activity NAS16142408
    GO:0005524NOT ATP binding NAS16142408
    GO:0008022protein C-terminus binding ISS16135750
         
    Find genes that share ontologies with PXK           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PXK
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    miRNA
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    miRTarBase miRNAs that target PXK:
    hsa-mir-744-5p (MIRT037408)

    Block miRNA regulation of human, mouse, rat PXK using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate PXK:
    hsa-miR-30c hsa-miR-892b hsa-miR-30d hsa-miR-30a hsa-miR-149 hsa-miR-30b hsa-miR-24 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidPXK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PXK

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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for PXK 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PXK_HUMAN, Q7Z7A4: Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma
    membrane. Isoform 3 is present throughout the cell
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytoskeleton4
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16142408
    GO:0005737cytoplasm ISS16135750
    GO:0005813centrosome ----
    GO:0005815microtubule organizing center IDA--
    GO:0005886plasma membrane ISS16135750

    Find genes that share ontologies with PXK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PXK
    Interactions:

        Search GeneGlobe Interaction Network for PXK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for PXK (Q7Z7A43 ENSP000003484724) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LAMP2P134733, ENSP000004084114I2D: score=1 STRING: ENSP00000408411
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    EEA1Q150753, ENSP000003179554I2D: score=1 STRING: ENSP00000317955
    ACTBL2Q562R13, ENSP000004167064I2D: score=1 STRING: ENSP00000416706
    TFRCP027863, ENSP000003532244I2D: score=1 STRING: ENSP00000353224
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation NAS16142408
    GO:0006954inflammatory response IMP18204446
    GO:0007154cell communication ----
    GO:0032780negative regulation of ATPase activity ISS16135750
    GO:0043271negative regulation of ion transport ISS16135750

    Find genes that share ontologies with PXK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PXK



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PXK gene (7 alternative transcripts): 
    NM_001289095.1  NM_001289096.1  NM_001289098.1  NM_001289099.1  NM_001289100.1  NM_001289101.1  NM_017771.4  

    Unigene Cluster for PXK:

    PX domain containing serine/threonine kinase
    Hs.190544  [show with all ESTs]
    Unigene Representative Sequence: BX537600
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356151(uc003djz.1 uc003dka.1) ENST00000468776 ENST00000463280(uc011bfe.1)
    ENST00000383715 ENST00000484288(uc003djx.1) ENST00000479241 ENST00000477308
    ENST00000491164 ENST00000479134 ENST00000459676 ENST00000495557 ENST00000493474
    ENST00000302779(uc003dkb.1 uc003dkc.1) ENST00000383716(uc010hnj.1 uc003dkd.1 uc010hnk.1)
    ENST00000536660
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate PXK:
    hsa-miR-30c hsa-miR-892b hsa-miR-30d hsa-miR-30a hsa-miR-149 hsa-miR-30b hsa-miR-24 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidPXK 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PXK
    Predesigned siRNA for gene silencing in human, mouse, rat PXK
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PXK (NM_017771)
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    Addgene plasmids for PXK 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PXK
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PXK
      QuantiTect SYBR Green Assays in human, mouse, rat PXK
      QuantiFast Probe-based Assays in human, mouse, rat PXK

    Additional mRNA sequence: 

    AB209688.1 AF399753.1 AK000342.1 AK124775.1 AK131385.1 AK295542.1 AK296034.1 AK296215.1 
    AL137938.1 AY274811.1 AY437879.1 AY847220.1 AY847221.1 AY847222.1 BC008943.2 BC014479.1 
    BC108670.1 BX537600.1 DQ124707.1 DQ124708.1 

    18 DOTS entries:

    DT.451834  DT.304643  DT.92046477  DT.99968719  DT.92429917  DT.97845241  DT.100696990  DT.401238 
    DT.91978711  DT.95329626  DT.120876166  DT.120876177  DT.95170051  DT.120876201  DT.40288064  DT.91748535 
    DT.91955039  DT.95211812 

    Selected AceView cDNA sequences (see all 196):

    AI767770 AA401228 AA736869 AL137938 AA236244 N23166 AI684747 AA876354 
    AA280916 AA972640 AA278922 N48051 Z42307 AW515358 AW025731 F05572 
    AI239953 BQ549698 CA429691 BM469078 AW298269 AA906010 AA599286 BM663534 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PXK (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
    SP1:                    -                 -                                                                                                     -     -     -   
    SP2:                    -                 -                                                                                                                     
    SP3:                    -     -                                                                                                                 -     -     -   
    SP4:                    -     -           -                                                                                                     -     -     -   
    SP5:                    -     -     -     -     -     -                                                                                         -     -     -   

    ExUns: 22 ^ 23a · 23b · 23c · 23d · 23e
    SP1:  -                                 
    SP2:                                    
    SP3:  -                                 
    SP4:                                    
    SP5:  -                                 


    ECgene alternative splicing isoforms for PXK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PXK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAGAAAAA
    PXK Expression
    About this image


    PXK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PXK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PXK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.190544

    UniProtKB/Swiss-Prot: PXK_HUMAN, Q7Z7A4
    Tissue specificity: Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high
    levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated

        Custom PCR Arrays for PXK
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PXK gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pxk1 , 5 PX domain containing serine/threonine kinase1, 5 87.2(n)1
    92.04(a)1
      14 (4.70 cM)5
    2186991  NM_145458.31  NP_663433.21 
     80982135 
    chicken
    (Gallus gallus)
    Aves PXK1 PX domain containing serine/threonine kinase 76.88(n)
    85.42(a)
      416065  XM_414403.4  XP_414403.4 
    lizard
    (Anolis carolinensis)
    Reptilia PXK6
    PX domain containing serine/threonine kinase
    85(a)
    1 ↔ 1
    2(187232610-187302871)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pxk1 PX domain containing serine/threonine kinase 71.59(n)
    81.55(a)
      100485323  XM_002935048.2  XP_002935094.2 
    zebrafish
    (Danio rerio)
    Actinopterygii pxk1 PX domain containing serine/threonine kinase 68.65(n)
    73.03(a)
      557065  NM_001082808.1  NP_001076277.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG87261 CG8726 50.79(n)
    44.37(a)
      35758  NM_136497.4  NP_610341.2 


    ENSEMBL Gene Tree for PXK (if available)
    TreeFam Gene Tree for PXK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PXK gene
    3 SIMAP similar genes for PXK using alignment to 11 protein entries:     PXK_HUMAN (see all proteins):
    SNX16    SNX14    SGK3

    Find genes that share paralogs with PXK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PXK (see all 2101)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37962151,2
    C,F,H--58316657(-) CCCCGT/CTGAGT 1 -- us2k113Minor allele frequency- C:0.45NS EA NA CSA WA 764
    rs1921978781,2
    --58316761(+) GGTGGA/GATTAC 1 -- us2k10--------
    rs1405979561,2
    --58316912(+) AGACGG/TTCTTG 1 -- us2k10--------
    rs1837340511,2
    --58316981(+) CCTGTC/GCTCAA 1 -- us2k10--------
    rs768220941,2
    C--58317016(+) GAGTAA/GTTGGG 1 -- us2k10--------
    rs1477134451,2
    --58317051(+) CAGGTA/CTTTTT 1 -- us2k10--------
    rs1424541751,2
    --58317079(+) ACGGGA/GTCTCA 1 -- us2k10--------
    rs1891122301,2
    --58317093(+) TATTGC/TCCAGG 1 -- us2k10--------
    rs793241311,2
    C--58317097(+) GCCCAC/GGCTAA 1 -- us2k10--------
    rs1928190391,2
    --58317140(+) CCTCCC/GAAAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PXK (58318607 - 58411748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PXK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2337145CNV Deletion18987734
    nsv3838CNV Insertion18451855
    nsv528147CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PXK
    DNA2.0 Custom Variant and Variant Library Synthesis for PXK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611450    OMIM disorders: --

    2 diseases for PXK:    
    About MalaCards
    sle susceptibility    systemic lupus erythematosus


    Find genes that share disorders with PXK           About GenesLikeMe

    Genetic Association Database (GAD): PXK
    Human Genome Epidemiology (HuGE) Navigator: PXK (13 documents)

    Export disorders for PXK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PXK gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with PXK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. (PubMed id 16135750)1, 2, 9 Mao H....Levitan I.B. (J. Neurosci. 2005)
    2. Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients. (PubMed id 20881011)1, 4 Webb R....Sawalha A.H. (Ann. Rheum. Dis. 2011)
    3. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (Genes Immun. 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
    6. Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus. (PubMed id 20848568)1, 4 Sanchez E....AlarcA^n-Riquelme M.E. (Arthritis Rheum. 2010)
    7. Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese. (PubMed id 19225526)1, 4 Yang W....Lau Y.L. (Genes Immun. 2009)
    8. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. (PubMed id 18204446)1, 4 Harley J.B.... Kelly J.A. (Nat. Genet. 2008)
    9. Expression pattern and subcellular localization of five splice isoforms of human PXK. (PubMed id 16142408)1, 2 Zou X....Mao Y. (Int. J. Mol. Med. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54899 HGNC: 23326 AceView: PXK Ensembl:ENSG00000168297 euGenes: HUgn54899
    ECgene: PXK H-InvDB: PXK

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PXK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PXK gene:
    Search GeneIP for patents involving PXK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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