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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PXK Gene

protein-coding   GIFtS: 53
GCID: GC03P058318

PX Domain Containing Serine/Threonine Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
PX Domain Containing Serine/Threonine Kinase1 2     PX Ser/Thr Kinase V22
MONaKA2 3     PX Serine/Threonine Kinase2
Modulator Of Na,K-ATPase Long Form2     Modulator Of Na,K-ATPase3
PX Domain-Containing Protein Kinase-Like Protein2     MONAKA5

External Ids:    HGNC: 233261   Entrez Gene: 548992   Ensembl: ENSG000001682977   OMIM: 6114505   UniProtKB: Q7Z7A43   

Export aliases for PXK gene to outside databases

Previous GC identifers: GC03P058173 GC03P058275 GC03P058293


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PXK Gene:
PXK binds to the Na,K-ATPase beta-1 (ATP1B1; MIM 182330) and beta-3 (ATP1B3; MIM 601867) subunits and modulates
both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005 (PubMed 16135750)).(supplied by OMIM, Mar
2008)

GeneCards Summary for PXK Gene: 
PXK (PX domain containing serine/threonine kinase) is a protein-coding gene. Diseases associated with PXK include systemic lupus erythematosus, and lupus erythematosus. GO annotations related to this gene include protein kinase activity and nucleotide binding.

UniProtKB/Swiss-Prot: PXK_HUMAN, Q7Z7A4
Function: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the
regulation of electrical excitability and synaptic transmission. May not display kinase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PXK gene promoter:
         RP58   NF-YA   Meis-1b   NF-YB   CBF-A   CBF-B   Meis-1a   CP1A   NF-Y   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPXK promoter sequence
   Search SABiosciences Chromatin IP Primers for PXK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PXK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p21.2

PXK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PXK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P058318:  view genomic region     (about GC identifiers)

Start:
58,318,607 bp from pter      End:
58,411,748 bp from pter
Size:
93,142 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PXK_HUMAN, Q7Z7A4 (See protein sequence)
Recommended Name: PX domain-containing protein kinase-like protein  
Size: 578 amino acids; 64950 Da
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma
membrane. Isoform 3 is present throughout the cell
Sequence caution: Sequence=AAH14479.1; Type=Erroneous termination; Positions=451; Note=Translated as Gly;
Sequence=BAA91097.1; Type=Frameshift; Positions=569; Sequence=BAD18536.1; Type=Frameshift; Positions=510;
Sequence=BAD92925.1; Type=Frameshift; Positions=147;
Secondary accessions: Q3BCH4 Q3BCH5 Q3BCH6 Q3BDW1 Q45L83 Q59EX3 Q6PK17 Q6ZN39 Q96CA3 Q96R07
Q9NXB8
Alternative splicing: 7 isoforms:  Q7Z7A4-1   Q7Z7A4-2   Q7Z7A4-3   Q7Z7A4-4   Q7Z7A4-5   Q7Z7A4-6   Q7Z7A4-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PXK: NX_Q7Z7A4

Explore proteomics data for PXK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z7A4

  • PXK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PXK Protein Expression
    REFSEQ proteins: NP_060241.2  
    ENSEMBL proteins: 
     ENSP00000348472   ENSP00000417167   ENSP00000417903   ENSP00000373221   ENSP00000417915  
     ENSP00000419049   ENSP00000420403   ENSP00000418831   ENSP00000418202   ENSP00000476179  
     ENSP00000418376   ENSP00000418836   ENSP00000305045   ENSP00000373222   ENSP00000438356  

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    Novus Biologicals PXK Lysates
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    Cloud-Clone Corp. Proteins for PXK 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16142408
    GO:0005737cytoplasm ISS16135750
    GO:0005813centrosome IDA--
    GO:0005886plasma membrane ISS16135750

    PXK for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: PX domain containing serine/threonine kinase 
    Slob family

    4 InterPro protein domains:
     IPR001683 Phox
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z7A4

    ProtoNet protein and cluster: Q7Z7A4

    2 Blocks protein domains:
    IPB001683 Phox-like
    IPB003124 Actin-binding WH2


    UniProtKB/Swiss-Prot: PXK_HUMAN, Q7Z7A4
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 PX (phox homology) domain
    Similarity: Contains 1 WH2 domain


    PXK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PXK_HUMAN, Q7Z7A4
    Function: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the
    regulation of electrical excitability and synaptic transmission. May not display kinase activity

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166NOT nucleotide binding NAS16142408
    GO:0003779actin binding IEA--
    GO:0004672NOT protein kinase activity NAS16142408
    GO:0005515protein binding ----
    GO:0005524NOT ATP binding NAS16142408
         
    PXK for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidPXK 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PXK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for PXK (Q7Z7A43 ENSP000003484724) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LAMP2P134733, ENSP000004084114I2D: score=1 STRING: ENSP00000408411
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    EEA1Q150753, ENSP000003179554I2D: score=1 STRING: ENSP00000317955
    ACTBL2Q562R13, ENSP000004167064I2D: score=1 STRING: ENSP00000416706
    TFRCP027863, ENSP000003532244I2D: score=1 STRING: ENSP00000353224
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation NAS16142408
    GO:0006954inflammatory response IMP18204446
    GO:0007154cell communication IEA--
    GO:0032780negative regulation of ATPase activity ISS16135750
    GO:0043271negative regulation of ion transport ISS16135750

    PXK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PXK

    Search CenterWatch for drugs/clinical trials and news about PXK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PXK gene: 
    NM_017771.3  

    Unigene Cluster for PXK:

    PX domain containing serine/threonine kinase
    Hs.190544  [show with all ESTs]
    Unigene Representative Sequence: BX537600
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356151(uc003djz.1 uc003dka.1) ENST00000468776 ENST00000463280(uc011bfe.1)
    ENST00000383715 ENST00000484288(uc003djx.1) ENST00000479241 ENST00000477308
    ENST00000491164 ENST00000479134 ENST00000459676 ENST00000495557 ENST00000493474
    ENST00000302779(uc003dkb.1 uc003dkc.1) ENST00000383716(uc010hnj.1 uc003dkd.1 uc010hnk.1)
    ENST00000536660
    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate PXK:
    hsa-miR-30c hsa-miR-892b hsa-miR-30d hsa-miR-30a hsa-miR-149 hsa-miR-30b hsa-miR-24 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidPXK 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209688.1 AF399753.1 AK000342.1 AK124775.1 AK131385.1 AK295542.1 AK296034.1 AK296215.1 
    AL137938.1 AY274811.1 AY437879.1 AY847220.1 AY847221.1 AY847222.1 BC008943.2 BC014479.1 
    BC108670.1 BX537600.1 DQ124707.1 DQ124708.1 

    18 DOTS entries:

    DT.451834  DT.304643  DT.92046477  DT.99968719  DT.92429917  DT.97845241  DT.100696990  DT.401238 
    DT.91978711  DT.95329626  DT.120876166  DT.120876177  DT.95170051  DT.120876201  DT.40288064  DT.91748535 
    DT.91955039  DT.95211812 

    24/196 AceView cDNA sequences (see all 196):

    AA906010 AI684747 BM833998 BM663534 AA401228 CR592387 R69404 AW515358 
    N23166 CA429691 N39438 AA736869 AI239953 AI559359 AA280639 CA309097 
    CD240439 AI767770 AA876354 BQ549214 AI807685 AW470761 AI090988 AI479354 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PXK (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
    SP1:                    -                 -                                                                                                     -     -     -   
    SP2:                    -                 -                                                                                                                     
    SP3:                    -     -                                                                                                                 -     -     -   
    SP4:                    -     -           -                                                                                                     -     -     -   
    SP5:                    -     -     -     -     -     -                                                                                         -     -     -   

    ExUns: 22 ^ 23a · 23b · 23c · 23d · 23e
    SP1:  -                                 
    SP2:                                    
    SP3:  -                                 
    SP4:                                    
    SP5:  -                                 


    ECgene alternative splicing isoforms for PXK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PXK expression in normal human tissues (normalized intensities)      PXK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAGAAAAA
    PXK Expression
    About this image


    PXK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See PXK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PXK

    SOURCE GeneReport for Unigene cluster: Hs.190544

    UniProtKB/Swiss-Prot: PXK_HUMAN, Q7Z7A4
    Tissue specificity: Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high
    levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated

        SABiosciences Custom PCR Arrays for PXK
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PXK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PXK gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pxk1 , 5 PX domain containing serine/threonine kinase1, 5 87.89(n)1
    92.39(a)1
      14 (4.70 cM)5
    2186991  NM_145458.31  NP_663433.21 
     80982135 
    chicken
    (Gallus gallus)
    Aves PXK1 PX domain containing serine/threonine kinase 76.77(n)
    84.94(a)
      416065  XM_414403.3  XP_414403.3 
    lizard
    (Anolis carolinensis)
    Reptilia PXK6
    Uncharacterized protein
    84(a)
    1 ↔ 1
    2(187232610-187302871)
    zebrafish
    (Danio rerio)
    Actinopterygii pxk1 PX domain containing serine/threonine kinase 68.88(n)
    73.38(a)
      557065  NM_001082808.1  NP_001076277.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG87261 CG8726 48.21(n)
    41.79(a)
      35758  NM_136497.4  NP_610341.2 


    ENSEMBL Gene Tree for PXK (if available)
    TreeFam Gene Tree for PXK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PXK gene
    3 SIMAP similar genes for PXK using alignment to 10 protein entries:     PXK_HUMAN (see all proteins):
    SNX16    SNX14    SGK3

    PXK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2101 SNPs in PXK are shown (see all 2101)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37962151,2
    C,F,H--58316657(-) CCCCGT/CTGAGT 1 -- us2k113Minor allele frequency- C:0.45NS EA NA CSA WA 764
    rs1921978781,2
    --58316761(+) GGTGGA/GATTAC 1 -- us2k10--------
    rs1405979561,2
    --58316912(+) AGACGG/TTCTTG 1 -- us2k10--------
    rs1837340511,2
    --58316981(+) CCTGTC/GCTCAA 1 -- us2k10--------
    rs768220941,2
    C--58317016(+) GAGTAA/GTTGGG 1 -- us2k10--------
    rs1477134451,2
    --58317051(+) CAGGTA/CTTTTT 1 -- us2k10--------
    rs1424541751,2
    --58317079(+) ACGGGA/GTCTCA 1 -- us2k10--------
    rs1891122301,2
    --58317093(+) TATTGC/TCCAGG 1 -- us2k10--------
    rs793241311,2
    C--58317097(+) GCCCAC/GGCTAA 1 -- us2k10--------
    rs1928190391,2
    --58317140(+) CCTCCC/GAAAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PXK (58318607 - 58411748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PXK:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2337145CNV Deletion18987734
    nsv3838CNV Insertion18451855
    nsv528147CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611450    OMIM disorders: --

    4 diseases for PXK:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    rheumatoid arthritis    arthritis


    PXK for disorders           About GeneDecksing

    Genetic Association Database (GAD): PXK
    Human Genome Epidemiology (HuGE) Navigator: PXK (13 documents)

    Export disorders for PXK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PXK gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with PXK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. (PubMed id 16135750)1, 2, 9 Mao H....Levitan I.B. (2005)
    2. Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients . (PubMed id 20881011)1, 4 Webb R....Sawalha A.H. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (2010)
    5. A targeted association study in systemic lupus erythe matosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (2010)
    6. Genetically determined amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus. (PubMed id 20848568)1, 4 Sanchez E....AlarcA^n-Riquelme M.E. (2010)
    7. Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese. (PubMed id 19225526)1, 4 Yang W....Lau Y.L. (2009)
    8. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. (PubMed id 18204446)1, 4 Harley J.B.... Kelly J.A. (2008)
    9. Expression pattern and subcellular localization of five splice isoforms of human PXK. (PubMed id 16142408)1, 2 Zou X....Mao Y. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54899 HGNC: 23326 AceView: PXK Ensembl:ENSG00000168297 euGenes: HUgn54899
    ECgene: PXK H-InvDB: PXK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PXK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PXK gene:
    Search GeneIP for patents involving PXK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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