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Aliases for PXK Gene

Aliases for PXK Gene

  • PX Domain Containing Serine/Threonine Kinase 2 3
  • MONaKA 3 4 6
  • PX Domain-Containing Protein Kinase-Like Protein 3
  • Modulator Of Na,K-ATPase Long Form 3
  • PX Serine/Threonine Kinase 3
  • Modulator Of Na,K-ATPase 4
  • PX Ser/Thr Kinase V2 3

External Ids for PXK Gene

Previous GeneCards Identifiers for PXK Gene

  • GC03P058173
  • GC03P058275
  • GC03P058293

Summaries for PXK Gene

Entrez Gene Summary for PXK Gene

  • This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for PXK Gene

PXK (PX Domain Containing Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with PXK include systemic lupus erythematosus. GO annotations related to this gene include nucleotide binding and protein kinase activity.

UniProtKB/Swiss-Prot for PXK Gene

  • Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PXK Gene

Genomics for PXK Gene

Regulatory Elements for PXK Gene

Genomic Location for PXK Gene

58,332,880 bp from pter
58,426,127 bp from pter
93,248 bases
Plus strand

Genomic View for PXK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PXK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXK Gene

Proteins for PXK Gene

  • Protein details for PXK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PX domain-containing protein kinase-like protein
    Protein Accession:
    Secondary Accessions:
    • Q3BCH4
    • Q3BCH5
    • Q3BCH6
    • Q3BDW1
    • Q45L83
    • Q59EX3
    • Q6PK17
    • Q6ZN39
    • Q96CA3
    • Q96R07
    • Q9NXB8

    Protein attributes for PXK Gene

    578 amino acids
    Molecular mass:
    64950 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH14479.1; Type=Erroneous termination; Positions=451; Note=Translated as Gly.; Evidence={ECO:0000305}; Sequence=BAA91097.1; Type=Frameshift; Positions=569; Evidence={ECO:0000305}; Sequence=BAD18536.1; Type=Frameshift; Positions=510; Evidence={ECO:0000305}; Sequence=BAD92925.1; Type=Frameshift; Positions=147; Evidence={ECO:0000305};

    Alternative splice isoforms for PXK Gene

neXtProt entry for PXK Gene

Proteomics data for PXK Gene at MOPED

Post-translational modifications for PXK Gene

  • Ubiquitination at Lys406
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PXK Gene

Domains for PXK Gene

Gene Families for PXK Gene

Protein Domains for PXK Gene

Suggested Antigen Peptide Sequences for PXK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7Z7A4
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 protein kinase domain.
  • Contains 1 PX (phox homology) domain.
  • Contains 1 WH2 domain.
  • Belongs to the protein kinase superfamily.
genes like me logo Genes that share domains with PXK: view

Function for PXK Gene

Molecular function for PXK Gene

UniProtKB/Swiss-Prot Function: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

Gene Ontology (GO) - Molecular Function for PXK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 NOT nucleotide binding NAS 16142408
GO:0003779 actin binding IEA --
GO:0004672 NOT protein kinase activity NAS 16142408
GO:0005524 NOT ATP binding NAS 16142408
GO:0008022 protein C-terminus binding ISS 16135750
genes like me logo Genes that share ontologies with PXK: view

Animal Model Products

CRISPR Products

miRNA for PXK Gene

miRTarBase miRNAs that target PXK

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PXK Gene

Localization for PXK Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXK Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma membrane. Isoform 3 is present throughout the cell.

Subcellular locations from

Jensen Localization Image for PXK Gene COMPARTMENTS Subcellular localization image for PXK gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for PXK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16142408
GO:0005737 cytoplasm ISS 16135750
GO:0005815 microtubule organizing center IDA --
GO:0005886 plasma membrane ISS 16135750
genes like me logo Genes that share ontologies with PXK: view

Pathways for PXK Gene

SuperPathways for PXK Gene

No Data Available

Gene Ontology (GO) - Biological Process for PXK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 NOT protein phosphorylation NAS 16142408
GO:0006954 inflammatory response IMP 18204446
GO:0008152 metabolic process --
GO:0032780 negative regulation of ATPase activity ISS 16135750
GO:0043271 negative regulation of ion transport ISS 16135750
genes like me logo Genes that share ontologies with PXK: view

No data available for Pathways by source for PXK Gene

Transcripts for PXK Gene

Unigene Clusters for PXK Gene

PX domain containing serine/threonine kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PXK

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PXK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PXK Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP8: - - -
SP9: -
SP10: - - - -

ExUns: 22 ^ 23a · 23b · 23c · 23d · 23e
SP1: -
SP3: -
SP5: -
SP6: -
SP8: -
SP10: -

Relevant External Links for PXK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PXK Gene

mRNA expression in normal human tissues for PXK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PXK Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PXK Gene

SOURCE GeneReport for Unigene cluster for PXK Gene Hs.190544

mRNA Expression by UniProt/SwissProt for PXK Gene

Tissue specificity: Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated.
genes like me logo Genes that share expressions with PXK: view

In Situ Assay Products

Orthologs for PXK Gene

This gene was present in the common ancestor of animals.

Orthologs for PXK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PXK 35
  • 99.65 (n)
  • 100 (a)
PXK 36
  • 100 (a)
(Bos Taurus)
Mammalia PXK 35
  • 92.45 (n)
  • 96.71 (a)
PXK 36
  • 96 (a)
(Canis familiaris)
Mammalia PXK 35
  • 90.72 (n)
  • 93.77 (a)
PXK 36
  • 79 (a)
(Mus musculus)
Mammalia Pxk 35
  • 87.2 (n)
  • 92.04 (a)
Pxk 16
Pxk 36
  • 92 (a)
(Monodelphis domestica)
Mammalia PXK 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia PXK 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Pxk 35
  • 88.21 (n)
  • 92.37 (a)
(Gallus gallus)
Aves PXK 35
  • 76.88 (n)
  • 85.42 (a)
PXK 36
  • 85 (a)
(Anolis carolinensis)
Reptilia PXK 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pxk 35
  • 71.59 (n)
  • 81.55 (a)
(Danio rerio)
Actinopterygii pxk 35
  • 68.65 (n)
  • 73.03 (a)
pxk 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005173 35
  • 50.61 (n)
  • 42.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8726 35
  • 50.79 (n)
  • 44.37 (a)
CG8726 36
  • 36 (a)
Slob 36
  • 10 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13413 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2714 36
  • 50 (a)
Species with no ortholog for PXK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PXK Gene

Gene Tree for PXK (if available)
Gene Tree for PXK (if available)

Paralogs for PXK Gene

genes like me logo Genes that share paralogs with PXK: view

No data available for Paralogs for PXK Gene

Variants for PXK Gene

Sequence variations from dbSNP and Humsavar for PXK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1131052 -- 58,425,803(+) ATATC(A/T)ATATA utr-variant-3-prime
rs2063644 -- 58,345,215(+) GGCTT(A/T)GGGAA intron-variant
rs2090238 -- 58,365,043(-) CAGAA(A/G)AAGGA intron-variant
rs2138239 -- 58,363,414(-) aaggt(A/C)atgac intron-variant
rs2176082 -- 58,345,459(-) TGTTT(C/T)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PXK Gene

Variant ID Type Subtype PubMed ID
nsv528147 CNV Gain 19592680
esv2337145 CNV Deletion 18987734
nsv3838 CNV Insertion 18451855

Relevant External Links for PXK Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXK Gene

Disorders for PXK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PXK Gene including...

Search for PXK Gene in MalaCards »

Relevant External Links for PXK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PXK: view

No data available for UniProtKB/Swiss-Prot for PXK Gene

Publications for PXK Gene

  1. MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. (PMID: 16135750) Mao H. … Levitan I.B. (J. Neurosci. 2005) 3 4 23
  2. Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking. (PMID: 20086096) Takeuchi H. … Hirata M. (Mol. Cell. Biol. 2010) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Expression pattern and subcellular localization of five splice isoforms of human PXK. (PMID: 16142408) Zou X. … Mao Y. (Int. J. Mol. Med. 2005) 3 4

Products for PXK Gene

  • Addgene plasmids for PXK

Sources for PXK Gene

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