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Aliases for PXDNL Gene

Aliases for PXDNL Gene

  • Peroxidasin-Like 2 3
  • Vascular Peroxidase 2 3 4
  • Cardiac Peroxidase 3 4
  • EC 1.11.1.7 4 63
  • PRM1 3 4
  • VPO2 3 4
  • Polysomal Ribonuclease 1 Homolog (Xenopus) 2
  • Peroxidasin Homolog-Like (Drosophila) 2
  • Peroxidasin Homolog (Drosophila)-Like 2
  • Polysomal Ribonuclease 1 Homolog 3
  • Cardiovascular Peroxidase 2 3
  • Peroxidasin Homolog-Like 3
  • Polysomal Ribonuclease 1 4
  • EC 1.11.1 63
  • PMR1 3

External Ids for PXDNL Gene

Previous GeneCards Identifiers for PXDNL Gene

  • GC08M052395
  • GC08M052232
  • GC08M047697

Summaries for PXDNL Gene

GeneCards Summary for PXDNL Gene

PXDNL (Peroxidasin-Like) is a Protein Coding gene. Diseases associated with PXDNL include hypertrophy of breast. GO annotations related to this gene include heme binding and peroxidase activity. An important paralog of this gene is MPO.

UniProtKB/Swiss-Prot for PXDNL Gene

  • Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PXDNL Gene

Genomics for PXDNL Gene

Regulatory Elements for PXDNL Gene

Genomic Location for PXDNL Gene

Chromosome:
8
Start:
51,319,575 bp from pter
End:
51,811,029 bp from pter
Size:
491,455 bases
Orientation:
Minus strand

Genomic View for PXDNL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PXDNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXDNL Gene

Proteins for PXDNL Gene

  • Protein details for PXDNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1KZ92-PXDNL_HUMAN
    Recommended name:
    Peroxidasin-like protein
    Protein Accession:
    A1KZ92
    Secondary Accessions:
    • B5ME43
    • B6CGZ3
    • H0YBM9
    • Q6ZMR2
    • Q96LH9

    Protein attributes for PXDNL Gene

    Size:
    1463 amino acids
    Molecular mass:
    163686 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Cofactor:
    Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX70929.1; Type=Frameshift; Positions=127, 132; Evidence={ECO:0000305}; Sequence=BAB71713.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD18663.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW86707.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PXDNL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PXDNL Gene

Proteomics data for PXDNL Gene at MOPED

Selected DME Specific Peptides for PXDNL Gene

Post-translational modifications for PXDNL Gene

  • Phosphorylation by SRC on tyrosine residues is required for targeting to polysomes.
  • Glycosylation at Asn 387
  • Modification sites at PhosphoSitePlus

Other Protein References for PXDNL Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PXDNL Gene

Gene Families for PXDNL Gene

Suggested Antigen Peptide Sequences for PXDNL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1KZ92

UniProtKB/Swiss-Prot:

PXDNL_HUMAN :
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the peroxidase family. XPO subfamily.
  • Contains 5 LRR (leucine-rich) repeats.
Domain:
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 1 VWFC domain.
Family:
  • Belongs to the peroxidase family. XPO subfamily.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with PXDNL: view

Function for PXDNL Gene

Molecular function for PXDNL Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O
UniProtKB/Swiss-Prot Function:
Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.

Enzyme Numbers (IUBMB) for PXDNL Gene

Gene Ontology (GO) - Molecular Function for PXDNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0004601 peroxidase activity ISS --
GO:0005515 protein binding --
GO:0020037 heme binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PXDNL: view

Phenotypes for PXDNL Gene

genes like me logo Genes that share phenotypes with PXDNL: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PXDNL

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PXDNL Gene

Localization for PXDNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXDNL Gene

Secreted.
Isoform PMR1: Cytoplasm. Note=Associates with polysomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PXDNL Gene COMPARTMENTS Subcellular localization image for PXDNL gene
Compartment Confidence
extracellular 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PXDNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PXDNL: view

Pathways & Interactions for PXDNL Gene

SuperPathways for PXDNL Gene

No Data Available

Interacting Proteins for PXDNL Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000348645%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000348645 for PXDNL Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for PXDNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0042744 hydrogen peroxide catabolic process ISS --
GO:0055114 oxidation-reduction process ISS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with PXDNL: view

No data available for Pathways by source and SIGNOR curated interactions for PXDNL Gene

Drugs & Compounds for PXDNL Gene

(3) Drugs for PXDNL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
Hydrogen peroxide Pharma 42
Calcium Nutra 0

(2) Additional Compounds for PXDNL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PXDNL: view

Transcripts for PXDNL Gene

mRNA/cDNA for PXDNL Gene

Unigene Clusters for PXDNL Gene

Peroxidasin homolog (Drosophila)-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PXDNL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PXDNL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - - -
SP3:

Relevant External Links for PXDNL Gene

GeneLoc Exon Structure for
PXDNL
ECgene alternative splicing isoforms for
PXDNL

Expression for PXDNL Gene

mRNA expression in normal human tissues for PXDNL Gene

mRNA differential expression in normal tissues according to GTEx for PXDNL Gene

This gene is overexpressed in Heart - Atrial Appendage (x25.1) and Heart - Left Ventricle (x19.3).

Protein differential expression in normal tissues from HIPED for PXDNL Gene

This gene is overexpressed in Monocytes (46.7) and Adipocyte (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PXDNL Gene



SOURCE GeneReport for Unigene cluster for PXDNL Gene Hs.444882

mRNA Expression by UniProt/SwissProt for PXDNL Gene

A1KZ92-PXDNL_HUMAN
Tissue specificity: the 57 kDa isoform PMR1 is the only form detected at protein levels in human cell lines.
genes like me logo Genes that share expression patterns with PXDNL: view

Protein tissue co-expression partners for PXDNL Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PXDNL Gene

Orthologs for PXDNL Gene

This gene was present in the common ancestor of animals.

Orthologs for PXDNL Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PXDNL 35
  • 84.45 (n)
  • 81.53 (a)
PXDNL 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PXDNL 35
  • 99.2 (n)
  • 98.84 (a)
PXDNL 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PXDNL 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PXDNL 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PXDNL 35
  • 63.52 (n)
  • 62.15 (a)
PXDNL 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PXDNL 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pxn 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C16C8.2 36
  • 33 (a)
ManyToMany
C46A5.4 36
  • 19 (a)
ManyToMany
F32A5.2 36
  • 28 (a)
ManyToMany
F49E12.1 36
  • 34 (a)
ManyToMany
pxn-1 36
  • 33 (a)
ManyToMany
pxn-2 36
  • 31 (a)
ManyToMany
T06D8.10 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for PXDNL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PXDNL Gene

ENSEMBL:
Gene Tree for PXDNL (if available)
TreeFam:
Gene Tree for PXDNL (if available)

Paralogs for PXDNL Gene

Paralogs for PXDNL Gene

(14) SIMAP similar genes for PXDNL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PXDNL: view

Variants for PXDNL Gene

Sequence variations from dbSNP and Humsavar for PXDNL Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs718250 -- 51,802,228(-) AAACA(G/T)TAACT intron-variant
rs718251 -- 51,801,963(-) ATGTC(G/T)CCTGG intron-variant
rs719162 -- 51,399,024(-) TCTAC(C/T)GTCAT intron-variant
rs719708 -- 51,319,225(-) CTTTA(A/G)AGTAG downstream-variant-500B
rs722495 -- 51,803,179(-) CCCAG(A/C)AGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PXDNL Gene

Variant ID Type Subtype PubMed ID
nsv890895 CNV Gain 21882294
nsv6190 CNV Insertion 18451855
nsv817615 CNV Gain 22305530
esv2672612 CNV Deletion 23128226
esv2675507 CNV Deletion 23128226
esv1005621 CNV Deletion 20482838
esv2496359 CNV Deletion 19546169
esv2236053 CNV Deletion 18987734
esv2736997 CNV Deletion 23290073
nsv890896 CNV Loss 21882294
esv2658183 CNV Deletion 23128226
nsv831313 CNV Loss 17160897
nsv516548 CNV Gain 19592680
nsv890897 CNV Loss 21882294
esv2663722 CNV Deletion 23128226
nsv398056 CNV Loss 16902084
nsv890898 CNV Loss 21882294
esv2528133 CNV Deletion 19546169
esv2555190 CNV Insertion 19546169
esv1455278 CNV Insertion 17803354
nsv6191 CNV Insertion 18451855
nsv824629 CNV Loss 20364138
nsv831316 CNV Gain 17160897
nsv509265 CNV Insertion 20534489
esv998610 CNV Insertion 20482838
esv1518773 CNV Insertion 17803354

Variation tolerance for PXDNL Gene

Residual Variation Intolerance Score: 97.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.15; 98.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PXDNL Gene

HapMap Linkage Disequilibrium report
PXDNL
Human Gene Mutation Database (HGMD)
PXDNL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXDNL Gene

Disorders for PXDNL Gene

MalaCards: The human disease database

(1) MalaCards diseases for PXDNL Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypertrophy of breast
  • large breast
- elite association
Search PXDNL in MalaCards View complete list of genes associated with diseases

Relevant External Links for PXDNL

Genetic Association Database (GAD)
PXDNL
Human Genome Epidemiology (HuGE) Navigator
PXDNL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PXDNL
genes like me logo Genes that share disorders with PXDNL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PXDNL Gene

Publications for PXDNL Gene

  1. Peroxidasins: novel players in tissue genesis. (PMID: 24924147) PActerfi Z. … Geiszt M. (Trends Biochem. Sci. 2014) 2 67
  2. Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein. (PMID: 22543864) Gu S.Q. … Schoenberg D.R. (RNA 2012) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A. … Wigdahl B. (J. Neurovirol. 2013) 67

Products for PXDNL Gene

Sources for PXDNL Gene

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