Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PXDNL Gene

Aliases for PXDNL Gene

  • Peroxidasin Like 2 3 5
  • Vascular Peroxidase 2 3 4
  • Cardiac Peroxidase 3 4
  • EC 4 63
  • PRM1 3 4
  • VPO2 3 4
  • Polysomal Ribonuclease 1 Homolog (Xenopus) 2
  • Peroxidasin Homolog-Like (Drosophila) 2
  • Peroxidasin Homolog (Drosophila)-Like 2
  • Polysomal Ribonuclease 1 Homolog 3
  • Cardiovascular Peroxidase 2 3
  • Peroxidasin Homolog-Like 3
  • Polysomal Ribonuclease 1 4
  • Peroxidasin-Like 3
  • EC 1.11.1 63
  • PMR1 3

External Ids for PXDNL Gene

Previous GeneCards Identifiers for PXDNL Gene

  • GC08M052395
  • GC08M052232
  • GC08M047697

Summaries for PXDNL Gene

GeneCards Summary for PXDNL Gene

PXDNL (Peroxidasin Like) is a Protein Coding gene. Diseases associated with PXDNL include hypertrophy of breast. GO annotations related to this gene include heme binding and peroxidase activity. An important paralog of this gene is EPX.

UniProtKB/Swiss-Prot for PXDNL Gene

  • Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PXDNL Gene

Genomics for PXDNL Gene

Regulatory Elements for PXDNL Gene

Genomic Location for PXDNL Gene

51,319,575 bp from pter
51,811,029 bp from pter
491,455 bases
Minus strand

Genomic View for PXDNL Gene

Genes around PXDNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PXDNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PXDNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXDNL Gene

Proteins for PXDNL Gene

  • Protein details for PXDNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peroxidasin-like protein
    Protein Accession:
    Secondary Accessions:
    • B5ME43
    • B6CGZ3
    • H0YBM9
    • Q6ZMR2
    • Q96LH9

    Protein attributes for PXDNL Gene

    1463 amino acids
    Molecular mass:
    163686 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=heme b; Xref=ChEBI:CHEBI:60344;
    Quaternary structure:
    No Data Available
    • Sequence=AAX70929.1; Type=Frameshift; Positions=127, 132; Evidence={ECO:0000305}; Sequence=BAB71713.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD18663.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW86707.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PXDNL Gene


neXtProt entry for PXDNL Gene

Proteomics data for PXDNL Gene at MOPED

Selected DME Specific Peptides for PXDNL Gene

Post-translational modifications for PXDNL Gene

  • Phosphorylation by SRC on tyrosine residues is required for targeting to polysomes.
  • Glycosylation at Asn 387
  • Modification sites at PhosphoSitePlus

Other Protein References for PXDNL Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PXDNL Gene

Gene Families for PXDNL Gene

Suggested Antigen Peptide Sequences for PXDNL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the peroxidase family. XPO subfamily.
  • Contains 5 LRR (leucine-rich) repeats.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 1 VWFC domain.
  • Belongs to the peroxidase family. XPO subfamily.
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with PXDNL: view

Function for PXDNL Gene

Molecular function for PXDNL Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.

Enzyme Numbers (IUBMB) for PXDNL Gene

Gene Ontology (GO) - Molecular Function for PXDNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0005515 protein binding IEA --
GO:0020037 heme binding IEA,ISS --
genes like me logo Genes that share ontologies with PXDNL: view

Phenotypes for PXDNL Gene

genes like me logo Genes that share phenotypes with PXDNL: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PXDNL Gene

Localization for PXDNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXDNL Gene

Isoform PMR1: Cytoplasm. Note=Associates with polysomes.

Subcellular locations from

Jensen Localization Image for PXDNL Gene COMPARTMENTS Subcellular localization image for PXDNL gene
Compartment Confidence
extracellular 5
lysosome 3
vacuole 3
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PXDNL Gene

Pathways & Interactions for PXDNL Gene

SuperPathways for PXDNL Gene

No Data Available

Interacting Proteins for PXDNL Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000348645 for PXDNL Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PXDNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0042744 hydrogen peroxide catabolic process ISS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0098869 cellular oxidant detoxification ISS --
genes like me logo Genes that share ontologies with PXDNL: view

No data available for Pathways by source and SIGNOR curated interactions for PXDNL Gene

Drugs & Compounds for PXDNL Gene

(3) Drugs for PXDNL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
Hydrogen peroxide Pharma 46
calcium Nutra 0

(2) Additional Compounds for PXDNL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with PXDNL: view

Transcripts for PXDNL Gene

mRNA/cDNA for PXDNL Gene

Unigene Clusters for PXDNL Gene

Peroxidasin homolog (Drosophila)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PXDNL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - - -

Relevant External Links for PXDNL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PXDNL Gene

mRNA expression in normal human tissues for PXDNL Gene

mRNA differential expression in normal tissues according to GTEx for PXDNL Gene

This gene is overexpressed in Heart - Atrial Appendage (x25.1) and Heart - Left Ventricle (x19.3).

Protein differential expression in normal tissues from HIPED for PXDNL Gene

This gene is overexpressed in Monocytes (46.7) and Adipocyte (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PXDNL Gene

SOURCE GeneReport for Unigene cluster for PXDNL Gene Hs.444882

mRNA Expression by UniProt/SwissProt for PXDNL Gene

Tissue specificity: the 57 kDa isoform PMR1 is the only form detected at protein levels in human cell lines.
genes like me logo Genes that share expression patterns with PXDNL: view

Protein tissue co-expression partners for PXDNL Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PXDNL Gene

Orthologs for PXDNL Gene

This gene was present in the common ancestor of animals.

Orthologs for PXDNL Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PXDNL 35
  • 84.45 (n)
  • 81.53 (a)
  • 81 (a)
(Pan troglodytes)
Mammalia PXDNL 35
  • 99.2 (n)
  • 98.84 (a)
  • 99 (a)
(Monodelphis domestica)
Mammalia PXDNL 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia PXDNL 36
  • 69 (a)
(Gallus gallus)
Aves PXDNL 35
  • 63.52 (n)
  • 62.15 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia PXDNL 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pxn 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea C16C8.2 36
  • 33 (a)
C46A5.4 36
  • 19 (a)
F32A5.2 36
  • 28 (a)
F49E12.1 36
  • 34 (a)
pxn-1 36
  • 33 (a)
pxn-2 36
  • 31 (a)
T06D8.10 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for PXDNL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PXDNL Gene

Gene Tree for PXDNL (if available)
Gene Tree for PXDNL (if available)

Paralogs for PXDNL Gene

Paralogs for PXDNL Gene

(14) SIMAP similar genes for PXDNL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PXDNL: view

Variants for PXDNL Gene

Sequence variations from dbSNP and Humsavar for PXDNL Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7833909 - 51,453,740(+) TGCCA(A/G)TTAAA nc-transcript-variant, reference, missense
rs16916235 - 51,423,622(+) AATTC(C/T)GAGCC nc-transcript-variant, reference, synonymous-codon, missense
rs16916207 - 51,413,207(+) CAGCA(G/T)CAAGA intron-variant, nc-transcript-variant, reference, missense
rs2977020 - 51,408,683(+) GGCCA(A/C/T)CCTGT nc-transcript-variant, downstream-variant-500B, reference, missense
rs11774588 - 51,345,869(+) TATCA(A/G/T)CAGGA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PXDNL Gene

Variant ID Type Subtype PubMed ID
nsv890895 CNV Gain 21882294
nsv6190 CNV Insertion 18451855
nsv817615 CNV Gain 22305530
esv2672612 CNV Deletion 23128226
esv2675507 CNV Deletion 23128226
esv1005621 CNV Deletion 20482838
esv2496359 CNV Deletion 19546169
esv2236053 CNV Deletion 18987734
esv2736997 CNV Deletion 23290073
nsv890896 CNV Loss 21882294
esv2658183 CNV Deletion 23128226
nsv831313 CNV Loss 17160897
nsv516548 CNV Gain 19592680
nsv890897 CNV Loss 21882294
esv2663722 CNV Deletion 23128226
nsv398056 CNV Loss 16902084
nsv890898 CNV Loss 21882294
esv2528133 CNV Deletion 19546169
esv2555190 CNV Insertion 19546169
esv1455278 CNV Insertion 17803354
nsv6191 CNV Insertion 18451855
nsv824629 CNV Loss 20364138
nsv831316 CNV Gain 17160897
nsv509265 CNV Insertion 20534489
esv998610 CNV Insertion 20482838
esv1518773 CNV Insertion 17803354

Variation tolerance for PXDNL Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.15; 98.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PXDNL Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXDNL Gene

Disorders for PXDNL Gene

MalaCards: The human disease database

(1) MalaCards diseases for PXDNL Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypertrophy of breast
  • breasts enlarged
- elite association - COSMIC cancer census association via MalaCards
Search PXDNL in MalaCards View complete list of genes associated with diseases

Relevant External Links for PXDNL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PXDNL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PXDNL Gene

Publications for PXDNL Gene

  1. Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein. (PMID: 22543864) Gu S.Q. … Schoenberg D.R. (RNA 2012) 2 3 4 67
  2. Peroxidasins: novel players in tissue genesis. (PMID: 24924147) PActerfi Z. … Geiszt M. (Trends Biochem. Sci. 2014) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A. … Wigdahl B. (J. Neurovirol. 2013) 3

Products for PXDNL Gene

Sources for PXDNL Gene

Back to Top