Aliases for PXDN Gene
External Ids for PXDN Gene
Previous GeneCards Identifiers for PXDN Gene
This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014]
GeneCards Summary for PXDN Gene
PXDN (Peroxidasin) is a Protein Coding gene. Diseases associated with PXDN include corneal opacification and other ocular anomalies and congenital cataract microcornea with corneal opacity. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling by GPCR. GO annotations related to this gene include heme binding and peroxidase activity. An important paralog of this gene is EPX.
UniProtKB/Swiss-Prot for PXDN Gene
Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.