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Aliases for PWP1 Gene

Aliases for PWP1 Gene

  • PWP1 Homolog, Endonuclein 2 3
  • Keratinocyte Protein IEF SSP 9502 3 4
  • Endonuclein 2 3
  • Nuclear Phosphoprotein Similar To S. Cerevisiae PWP1 3
  • PWP1 Homolog (S. Cerevisiae) 2
  • IEF-SSP-9502 3

External Ids for PWP1 Gene

Previous GeneCards Identifiers for PWP1 Gene

  • GC12P107190
  • GC12P107960
  • GC12P106582
  • GC12P108079
  • GC12P105139

Summaries for PWP1 Gene

GeneCards Summary for PWP1 Gene

PWP1 (PWP1 Homolog, Endonuclein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PWP1 Gene

  • May play an important role in cell growth and/or transcription

Gene Wiki entry for PWP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PWP1 Gene

Genomics for PWP1 Gene

Regulatory Elements for PWP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PWP1 Gene

Chromosome:
12
Start:
107,685,732 bp from pter
End:
107,713,167 bp from pter
Size:
27,436 bases
Orientation:
Plus strand

Genomic View for PWP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PWP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PWP1 Gene

Proteins for PWP1 Gene

  • Protein details for PWP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13610-PWP1_HUMAN
    Recommended name:
    Periodic tryptophan protein 1 homolog
    Protein Accession:
    Q13610
    Secondary Accessions:
    • A8K3R6
    • Q7Z3X9

    Protein attributes for PWP1 Gene

    Size:
    501 amino acids
    Molecular mass:
    55828 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PWP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PWP1 Gene

Proteomics data for PWP1 Gene at MOPED

Post-translational modifications for PWP1 Gene

  • Ubiquitination at Lys 376
  • Modification sites at PhosphoSitePlus

Other Protein References for PWP1 Gene

No data available for DME Specific Peptides for PWP1 Gene

Domains & Families for PWP1 Gene

Gene Families for PWP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13610

UniProtKB/Swiss-Prot:

PWP1_HUMAN :
  • Belongs to the WD repeat PWP1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat PWP1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with PWP1: view

Function for PWP1 Gene

Molecular function for PWP1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in cell growth and/or transcription

Gene Ontology (GO) - Molecular Function for PWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PWP1: view

Phenotypes for PWP1 Gene

genes like me logo Genes that share phenotypes with PWP1: view

Animal Model Products

miRNA for PWP1 Gene

miRTarBase miRNAs that target PWP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PWP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PWP1 Gene

Localization for PWP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PWP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PWP1 Gene COMPARTMENTS Subcellular localization image for PWP1 gene
Compartment Confidence
nucleus 5
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for PWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7828893
GO:0005730 nucleolus IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with PWP1: view

Pathways & Interactions for PWP1 Gene

SuperPathways for PWP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated TAS 7828893
genes like me logo Genes that share ontologies with PWP1: view

No data available for Pathways by source and SIGNOR curated interactions for PWP1 Gene

Drugs & Compounds for PWP1 Gene

No Compound Related Data Available

Transcripts for PWP1 Gene

Unigene Clusters for PWP1 Gene

PWP1 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PWP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PWP1 Gene

No ASD Table

Relevant External Links for PWP1 Gene

GeneLoc Exon Structure for
PWP1
ECgene alternative splicing isoforms for
PWP1

Expression for PWP1 Gene

mRNA expression in normal human tissues for PWP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PWP1 Gene

This gene is overexpressed in Lung (24.4) and Adrenal (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PWP1 Gene



SOURCE GeneReport for Unigene cluster for PWP1 Gene Hs.506652

mRNA Expression by UniProt/SwissProt for PWP1 Gene

Q13610-PWP1_HUMAN
Tissue specificity: High levels seen in the placenta, skeletal muscle, kidney and pancreas while lower levels were seen in the heart, brain and lung
genes like me logo Genes that share expression patterns with PWP1: view

Protein tissue co-expression partners for PWP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PWP1 Gene

Orthologs for PWP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PWP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PWP1 35
  • 92.47 (n)
  • 98 (a)
PWP1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PWP1 35
  • 93.73 (n)
  • 99 (a)
PWP1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pwp1 35
  • 84.8 (n)
  • 89.4 (a)
Pwp1 16
Pwp1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PWP1 35
  • 99.8 (n)
  • 100 (a)
PWP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pwp1 35
  • 84.2 (n)
  • 89.8 (a)
oppossum
(Monodelphis domestica)
Mammalia PWP1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves PWP1 35
  • 72.2 (n)
  • 72.47 (a)
PWP1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PWP1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pwp1 35
  • 70.9 (n)
  • 71.57 (a)
zebrafish
(Danio rerio)
Actinopterygii pwp1 35
  • 66.25 (n)
  • 71.01 (a)
zgc56486 35
pwp1 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6751 37
  • 35 (a)
nclb 35
  • 47.86 (n)
  • 38.53 (a)
nclb 36
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004768 35
  • 49.52 (n)
  • 45.24 (a)
worm
(Caenorhabditis elegans)
Secernentea JC8.2 37
  • 35 (a)
CELE_JC8.2 35
  • 49.19 (n)
  • 36.56 (a)
JC8.2 36
  • 34 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR078W 35
  • 47.67 (n)
  • 41.69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19515g 35
  • 47.61 (n)
  • 36.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PWP1 35
  • 49.34 (n)
  • 40.71 (a)
PWP1 36
  • 31 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G35370 35
  • 49.13 (n)
  • 38.95 (a)
rice
(Oryza sativa)
Liliopsida Os01g0924300 35
  • 50.61 (n)
  • 41.58 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02729 35
  • 49.41 (n)
  • 43.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1711.16 35
  • 48.54 (n)
  • 37.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for PWP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PWP1 Gene

ENSEMBL:
Gene Tree for PWP1 (if available)
TreeFam:
Gene Tree for PWP1 (if available)

Paralogs for PWP1 Gene

No data available for Paralogs for PWP1 Gene

Variants for PWP1 Gene

Sequence variations from dbSNP and Humsavar for PWP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs744266 -- 107,685,408(+) AATGA(A/G)ATGTA upstream-variant-2KB
rs744267 -- 107,685,669(-) GAATC(C/T)ACGTG upstream-variant-2KB
rs1106621 -- 107,684,331(+) aagca(A/G)accta upstream-variant-2KB
rs1802936 -- 107,697,527(+) TATAG(C/T)GGACT missense, reference
rs1802937 -- 107,712,281(+) AAAAA(C/T)GTTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PWP1 Gene

Variant ID Type Subtype PubMed ID
nsv899509 CNV Gain 21882294

Variation tolerance for PWP1 Gene

Residual Variation Intolerance Score: 34.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 69.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PWP1 Gene

HapMap Linkage Disequilibrium report
PWP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PWP1 Gene

Disorders for PWP1 Gene

Relevant External Links for PWP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PWP1
genes like me logo Genes that share disorders with PWP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PWP1 Gene

Publications for PWP1 Gene

  1. Cloning of a cDNA encoding a novel human nuclear phosphoprotein belonging to the WD-40 family. (PMID: 7828893) Honore B. … Celis J.E. (Gene 1994) 2 23 67
  2. Nuclear protein profiling of Jurkat cells during heat stress-induced apoptosis by 2-DE and MS/MS. (PMID: 17523140) Yuan X. … Nakamura K. (Electrophoresis 2007) 23 67
  3. Endonuclein is a cell cycle regulated WD-repeat protein that is up-regulated in adenocarcinoma of the pancreas. (PMID: 11850830) HonorAc B. … Vorum H. (Oncogene 2002) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for PWP1 Gene

Sources for PWP1 Gene

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