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Aliases for PWP1 Gene

Aliases for PWP1 Gene

  • PWP1 Homolog, Endonuclein 2 3 5
  • Keratinocyte Protein IEF SSP 9502 3 4
  • Endonuclein 2 3
  • Nuclear Phosphoprotein Similar To S. Cerevisiae PWP1 3
  • Periodic Tryptophan Protein 1 Homolog 3
  • PWP1 Homolog (S. Cerevisiae) 2
  • IEF-SSP-9502 3

External Ids for PWP1 Gene

Previous GeneCards Identifiers for PWP1 Gene

  • GC12P107190
  • GC12P107960
  • GC12P106582
  • GC12P108079
  • GC12P105139

Summaries for PWP1 Gene

Entrez Gene Summary for PWP1 Gene

  • The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for PWP1 Gene

PWP1 (PWP1 Homolog, Endonuclein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PWP1 Gene

  • May play an important role in cell growth and/or transcription.

Gene Wiki entry for PWP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PWP1 Gene

Genomics for PWP1 Gene

Regulatory Elements for PWP1 Gene

Enhancers for PWP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F108587 1.2 Ensembl ENCODE 74.4 +903.3 903285 2.4 HDGF YBX3 ATF1 ZNF493 INSM2 YBX1 PLRG1 ZNF155 GATA2 FOS SART3 PWP1 PRDM4 UBE3B ALKBH2 LOC101929162 RNU4-32P SELPLG TMEM119 ISCU
GH12F108626 1.6 FANTOM5 ENCODE 34.8 +947.7 947714 13.4 MLX CREB3L1 ZFP64 DMAP1 FEZF1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 SART3 PWP1 UBE3B PRDM4 CORO1C FICD SELPLG TMEM119 RPL17P38 RNU7-169P
GH12F108559 1.4 Ensembl ENCODE 22.5 +879.8 879843 12.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 PWP1 FICD ISCU ENSG00000256139 SART3 UBE3B PRDM4 TMEM119
GH12F108296 1.4 Ensembl ENCODE 22 +612.2 612218 3.5 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 SART3 PWP1 ALKBH2 CMKLR1 GC12M108289 GC12M108318
GH12F107735 0.9 ENCODE 26.1 +51.3 51342 2.5 HDAC1 PKNOX1 FEZF1 NFXL1 RAD21 ZBTB40 ZNF335 GLIS2 CREM SMARCA5 PWP1 PRDM4 LOC101929162 GC12M107739
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PWP1 on UCSC Golden Path with GeneCards custom track

Promoters for PWP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001467005 368 2600 PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for PWP1 Gene

Chromosome:
12
Start:
107,685,732 bp from pter
End:
107,713,167 bp from pter
Size:
27,436 bases
Orientation:
Plus strand

Genomic View for PWP1 Gene

Genes around PWP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PWP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PWP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PWP1 Gene

Proteins for PWP1 Gene

  • Protein details for PWP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13610-PWP1_HUMAN
    Recommended name:
    Periodic tryptophan protein 1 homolog
    Protein Accession:
    Q13610
    Secondary Accessions:
    • A8K3R6
    • Q7Z3X9

    Protein attributes for PWP1 Gene

    Size:
    501 amino acids
    Molecular mass:
    55828 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PWP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PWP1 Gene

Post-translational modifications for PWP1 Gene

  • Ubiquitination at Lys 376
  • Modification sites at PhosphoSitePlus

Other Protein References for PWP1 Gene

Antibody Products

  • Abcam antibodies for PWP1

No data available for DME Specific Peptides for PWP1 Gene

Domains & Families for PWP1 Gene

Gene Families for PWP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13610

UniProtKB/Swiss-Prot:

PWP1_HUMAN :
  • Belongs to the WD repeat PWP1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat PWP1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with PWP1: view

Function for PWP1 Gene

Molecular function for PWP1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in cell growth and/or transcription.

Gene Ontology (GO) - Molecular Function for PWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990889 H4K20me3 modified histone binding IEA --
genes like me logo Genes that share ontologies with PWP1: view
genes like me logo Genes that share phenotypes with PWP1: view

Animal Models for PWP1 Gene

MGI Knock Outs for PWP1:
  • Pwp1 tm1a(EUCOMM)Wtsi

Animal Model Products

miRNA for PWP1 Gene

miRTarBase miRNAs that target PWP1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PWP1 Gene

Localization for PWP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PWP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PWP1 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
mitochondrion 2
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7828893
GO:0005730 nucleolus IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with PWP1: view

Pathways & Interactions for PWP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated TAS 7828893
GO:0034773 histone H4-K20 trimethylation IEA --
GO:1903262 negative regulation of serine phosphorylation of STAT3 protein IEA --
GO:2000738 positive regulation of stem cell differentiation IEA --
genes like me logo Genes that share ontologies with PWP1: view

No data available for Pathways by source and SIGNOR curated interactions for PWP1 Gene

Transcripts for PWP1 Gene

Unigene Clusters for PWP1 Gene

PWP1 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PWP1 Gene

No ASD Table

Relevant External Links for PWP1 Gene

GeneLoc Exon Structure for
PWP1
ECgene alternative splicing isoforms for
PWP1

Expression for PWP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PWP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PWP1 Gene

This gene is overexpressed in Lung (24.4) and Adrenal (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PWP1 Gene



Protein tissue co-expression partners for PWP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PWP1 Gene:

PWP1

SOURCE GeneReport for Unigene cluster for PWP1 Gene:

Hs.506652

mRNA Expression by UniProt/SwissProt for PWP1 Gene:

Q13610-PWP1_HUMAN
Tissue specificity: High levels seen in the placenta, skeletal muscle, kidney and pancreas while lower levels were seen in the heart, brain and lung.
genes like me logo Genes that share expression patterns with PWP1: view

No data available for mRNA differential expression in normal tissues for PWP1 Gene

Orthologs for PWP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PWP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PWP1 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia PWP1 34 35
  • 93.73 (n)
cow
(Bos Taurus)
Mammalia PWP1 34 35
  • 92.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pwp1 34 16 35
  • 84.8 (n)
rat
(Rattus norvegicus)
Mammalia Pwp1 34
  • 84.2 (n)
oppossum
(Monodelphis domestica)
Mammalia PWP1 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PWP1 34 35
  • 72.2 (n)
lizard
(Anolis carolinensis)
Reptilia PWP1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pwp1 34
  • 70.9 (n)
zebrafish
(Danio rerio)
Actinopterygii pwp1 34 35
  • 66.25 (n)
zgc56486 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004768 34
  • 49.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta nclb 34 35
  • 47.86 (n)
CG6751 36
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_JC8.2 34
  • 49.19 (n)
JC8.2 36 35
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PWP1 34 35
  • 49.34 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR078W 34
  • 47.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19515g 34
  • 47.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G35370 34
  • 49.13 (n)
rice
(Oryza sativa)
Liliopsida Os01g0924300 34
  • 50.61 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02729 34
  • 49.41 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1711.16 34
  • 48.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for PWP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PWP1 Gene

ENSEMBL:
Gene Tree for PWP1 (if available)
TreeFam:
Gene Tree for PWP1 (if available)

Paralogs for PWP1 Gene

No data available for Paralogs for PWP1 Gene

Variants for PWP1 Gene

Sequence variations from dbSNP and Humsavar for PWP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10655986 -- 107,685,349(+) CTCAC(-/T/TT)TTTTT upstream-variant-2KB
rs10746092 -- 107,692,468(+) GGTCC(G/T)CAAGG intron-variant
rs10778567 -- 107,692,574(+) ATACA(A/G)TTCTT intron-variant
rs10778568 -- 107,694,019(+) AAGCG(A/G)ATGCT intron-variant
rs10778569 -- 107,694,127(+) TTGGT(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PWP1 Gene

Variant ID Type Subtype PubMed ID
esv3630693 CNV loss 21293372
nsv1038935 CNV gain 25217958
nsv560091 CNV gain 21841781

Variation tolerance for PWP1 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 69.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PWP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PWP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PWP1 Gene

Disorders for PWP1 Gene

Relevant External Links for PWP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PWP1

No disorders were found for PWP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PWP1 Gene

Publications for PWP1 Gene

  1. Cloning of a cDNA encoding a novel human nuclear phosphoprotein belonging to the WD-40 family. (PMID: 7828893) Honore B. … Celis J.E. (Gene 1994) 2 3 4 22 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Endonuclein is a cell cycle regulated WD-repeat protein that is up-regulated in adenocarcinoma of the pancreas. (PMID: 11850830) HonorAc B. … Vorum H. (Oncogene 2002) 2 3 64
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for PWP1 Gene

Sources for PWP1 Gene

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