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Aliases for PVT1 Gene

Subcategory (RNA class) for PVT1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for PVT1 Gene

  • Pvt1 Oncogene (Non-Protein Coding) 2 3 5
  • Pvt-1 (Murine) Oncogene Homolog, MYC Activator 2 3
  • Long Intergenic Non-Protein Coding RNA 79 2 3
  • Plasmacytoma Variant Translocation 1 3
  • Oncogene PVT-1 (MYC Activator) 3
  • Pvt1 Oncogene Homolog (Mouse) 2
  • Non-Protein Coding RNA 79 2
  • Onco-LncRNA-100 3
  • NCRNA00079 3
  • LINC00079 3
  • MYC 3

External Ids for PVT1 Gene

Previous GeneCards Identifiers for PVT1 Gene

  • GC08P127815
  • GC08U900029
  • GC08P128764
  • GC08P128876
  • GC08P128879
  • GC08P128807
  • GC08P124129
  • GC08P127797
  • GC08P127798
  • GC08P127799
  • GC08P127800

Summaries for PVT1 Gene

Entrez Gene Summary for PVT1 Gene

  • This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]

GeneCards Summary for PVT1 Gene

PVT1 (Pvt1 Oncogene (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with PVT1 include Plasmacytoma and Burkitt Lymphoma.

Gene Wiki entry for PVT1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PVT1 Gene

Genomics for PVT1 Gene

Regulatory Elements for PVT1 Gene

Enhancers for PVT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F127986 1.2 FANTOM5 Ensembl ENCODE 21.7 +193.3 193333 2.1 BCOR MAFG ZMYM3 CEBPG EBF1 RELA GATA3 ZNF316 ATF3 MAFK PVT1 MIR1205 RNU4-25P TMEM75 MIR1207 MIR1204 GC08P127985 GC08P128000
GH08F127972 1.5 FANTOM5 Ensembl ENCODE 17 +183.2 183229 9.5 HDAC1 PKNOX1 CBX3 TBL1XR1 ZFP64 GATA2 ZNF143 ETV6 SMARCA5 CEBPB PVT1 RNU1-106P TMEM75 RNU4-25P MIR1207 MIR1204 CASC11 MYC GC08P127985 MIR1205
GH08F127763 0.9 Ensembl ENCODE 22.8 -30.8 -30833 1.0 ZFP64 ZBTB11 ZBTB8A REST ZNF623 ZNF518A ZNF781 PRDM12 FOXP2 ZNF433 PVT1 MIR1204 MYC CASC11 MIR1207 TMEM75 GC08P127744
GH08F127758 1.5 FANTOM5 Ensembl ENCODE 12 -34.3 -34333 2.8 HDGF TBP HDAC1 ATF1 ARNT SIN3A ZBTB40 BRCA1 RFX5 CHAMP1 PVT1 MIR1204 MYC CASC11 TMEM75 MIR1207 RNU4-25P GC08P127744
GH08F127966 1.2 Ensembl ENCODE 15 +175.0 174990 6.6 PKNOX1 ATF1 SIN3A YY1 GATA2 FOS JUNB PPARG MEF2D MAFF PVT1 TMEM75 RNU4-25P RNU1-106P MYC CASC11 MIR1204 MIR1205 GC08P127985
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PVT1 on UCSC Golden Path with GeneCards custom track

Promoters for PVT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001401584 768 3400 ATF1 WRNIP1 ZFP64 SIN3A YBX1 DMAP1 JUNB REST TBX21 ZNF518A

Genomic Location for PVT1 Gene

Chromosome:
8
Start:
127,794,533 bp from pter
End:
128,101,253 bp from pter
Size:
306,721 bases
Orientation:
Plus strand

Genomic View for PVT1 Gene

Genes around PVT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PVT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PVT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PVT1 Gene

Proteins for PVT1 Gene

Post-translational modifications for PVT1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PVT1 Gene

Domains & Families for PVT1 Gene

Gene Families for PVT1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PVT1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PVT1 Gene

Function for PVT1 Gene

Molecular function for PVT1 Gene

GENATLAS Biochemistry:
plasmocytoma variant translocation (pvt-1) mouse oncogene homolog,c-myc activator (260kb,3) same as Mis1/MLVI-1

Phenotypes for PVT1 Gene

GenomeRNAi human phenotypes for PVT1:
genes like me logo Genes that share phenotypes with PVT1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PVT1 Gene

Localization for PVT1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PVT1 Gene

Pathways & Interactions for PVT1 Gene

No Data Available

Interacting Proteins for PVT1 Gene

Gene Ontology (GO) - Biological Process for PVT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PVT1 Gene

Transcripts for PVT1 Gene

Unigene Clusters for PVT1 Gene

Pvt1 oncogene (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PVT1 Gene

No ASD Table

Relevant External Links for PVT1 Gene

GeneLoc Exon Structure for
PVT1
ECgene alternative splicing isoforms for
PVT1

Expression for PVT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PVT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PVT1 Gene:

PVT1

SOURCE GeneReport for Unigene cluster for PVT1 Gene:

Hs.133107
genes like me logo Genes that share expression patterns with PVT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PVT1 Gene

Orthologs for PVT1 Gene

Evolution for PVT1 Gene

ENSEMBL:
Gene Tree for PVT1 (if available)
TreeFam:
Gene Tree for PVT1 (if available)

No data available for Orthologs for PVT1 Gene

Paralogs for PVT1 Gene

No data available for Paralogs for PVT1 Gene

Variants for PVT1 Gene

Sequence variations from dbSNP and Humsavar for PVT1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086182 -- 127,973,398(+) TGAAA(C/T)Gtccc intron-variant
rs10086557 -- 127,976,894(+) CACAG(C/T)ATCCC intron-variant
rs10086993 -- 128,000,226(+) CACAG(A/C)ATGAG intron-variant
rs10087240 -- 128,000,328(+) GGCAA(C/T)AAAAA intron-variant
rs10088204 -- 127,812,264(+) gaagg(A/C)aggaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PVT1 Gene

Variant ID Type Subtype PubMed ID
dgv4241e59 CNV duplication 20981092
esv2538862 CNV deletion 19546169
esv2662809 CNV deletion 23128226
esv2668349 CNV deletion 23128226
esv2752208 CNV gain 17911159
esv2761470 CNV loss 21179565
esv3334403 CNV insertion 20981092
esv3368834 CNV insertion 20981092
esv3441805 CNV duplication 20981092
esv3572989 CNV loss 25503493
esv3584895 CNV loss 24956385
esv3618784 CNV loss 21293372
esv3618785 CNV loss 21293372
esv3618786 CNV loss 21293372
esv3618787 CNV loss 21293372
esv3618789 CNV loss 21293372
esv3618790 CNV loss 21293372
esv3891479 CNV loss 25118596
nsv1109993 CNV deletion 24896259
nsv1161798 CNV duplication 26073780
nsv474033 CNV novel sequence insertion 20440878
nsv499795 OTHER inversion 21111241
nsv520172 CNV loss 19592680
nsv523895 CNV loss 19592680
nsv524801 CNV loss 19592680
nsv6388 CNV deletion 18451855
nsv7419 OTHER inversion 18451855

Relevant External Links for PVT1 Gene

Human Gene Mutation Database (HGMD)
PVT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PVT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PVT1 Gene

Disorders for PVT1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PVT1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
plasmacytoma
  • myeloma - solitary
burkitt lymphoma
  • burkitt's lymphoma
plasma cell neoplasm
  • plasma cell dyscrasia
mature b-cell neoplasm
  • mature b-cell lymphocytic neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search PVT1 in MalaCards View complete list of genes associated with diseases

Genatlas disease for PVT1 Gene

Burkitt lymphoma variant/acute lymphoblastic leukemia with translocations t(2;8)(p12;q24);t(8;22)(q24;q11)

Relevant External Links for PVT1

Genetic Association Database (GAD)
PVT1
Human Genome Epidemiology (HuGE) Navigator
PVT1
Tumor Gene Database (TGDB):
PVT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PVT1
genes like me logo Genes that share disorders with PVT1: view

No data available for UniProtKB/Swiss-Prot for PVT1 Gene

Publications for PVT1 Gene

  1. The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells. (PMID: 17503467) Carramusa L. … Feo S. (J. Cell. Physiol. 2007) 2 3 22 64
  2. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao W.J. … Zhang Z.Y. (World J. Gastroenterol. 2013) 2 3 64
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64
  4. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. (PMID: 20694011) Ferreira R.C. … HammarstrAPm L. (Nat. Genet. 2010) 3 46 64
  5. A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). (PMID: 21037568) Enciso-Mora V. … Houlston R.S. (Nat. Genet. 2010) 3 46 64

Products for PVT1 Gene

Sources for PVT1 Gene

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