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Aliases for PVT1 Gene

Subcategory (RNA class) for PVT1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for PVT1 Gene

  • Pvt1 Oncogene (Non-Protein Coding) 2 3 5
  • Pvt-1 (Murine) Oncogene Homolog, MYC Activator 2 3
  • Long Intergenic Non-Protein Coding RNA 79 2 3
  • Plasmacytoma Variant Translocation 1 3
  • Oncogene PVT-1 (MYC Activator) 3
  • Pvt1 Oncogene Homolog (Mouse) 2
  • Non-Protein Coding RNA 79 2
  • Onco-LncRNA-100 3
  • NCRNA00079 3
  • LINC00079 3

External Ids for PVT1 Gene

Previous GeneCards Identifiers for PVT1 Gene

  • GC08P127815
  • GC08U900029
  • GC08P128764
  • GC08P128876
  • GC08P128879
  • GC08P128807
  • GC08P124129
  • GC08P127797
  • GC08P127798

Summaries for PVT1 Gene

Entrez Gene Summary for PVT1 Gene

  • This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]

GeneCards Summary for PVT1 Gene

PVT1 (Pvt1 Oncogene (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with PVT1 include plasmacytoma.

Gene Wiki entry for PVT1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PVT1 Gene

Genomics for PVT1 Gene

Regulatory Elements for PVT1 Gene

Promoters for PVT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PVT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PVT1 Gene

Chromosome:
8
Start:
127,794,533 bp from pter
End:
128,101,253 bp from pter
Size:
306,721 bases
Orientation:
Plus strand

Genomic View for PVT1 Gene

Genes around PVT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PVT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PVT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PVT1 Gene

Proteins for PVT1 Gene

Post-translational modifications for PVT1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PVT1 Gene

Domains & Families for PVT1 Gene

Gene Families for PVT1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PVT1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PVT1 Gene

Function for PVT1 Gene

Molecular function for PVT1 Gene

GENATLAS Biochemistry:
plasmocytoma variant translocation (pvt-1) mouse oncogene homolog,c-myc activator (260kb,3) same as Mis1/MLVI-1

Phenotypes for PVT1 Gene

GenomeRNAi human phenotypes for PVT1:
genes like me logo Genes that share phenotypes with PVT1: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PVT1 Gene

Localization for PVT1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PVT1 Gene

Pathways & Interactions for PVT1 Gene

SuperPathways for PVT1 Gene

No Data Available

Interacting Proteins for PVT1 Gene

Gene Ontology (GO) - Biological Process for PVT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PVT1 Gene

Drugs & Compounds for PVT1 Gene

No Compound Related Data Available

Transcripts for PVT1 Gene

Unigene Clusters for PVT1 Gene

Pvt1 oncogene (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PVT1 Gene

No ASD Table

Relevant External Links for PVT1 Gene

GeneLoc Exon Structure for
PVT1
ECgene alternative splicing isoforms for
PVT1

Expression for PVT1 Gene

mRNA expression in normal human tissues for PVT1 Gene

SOURCE GeneReport for Unigene cluster for PVT1 Gene Hs.133107

genes like me logo Genes that share expression patterns with PVT1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PVT1 Gene

Orthologs for PVT1 Gene

Evolution for PVT1 Gene

ENSEMBL:
Gene Tree for PVT1 (if available)
TreeFam:
Gene Tree for PVT1 (if available)

No data available for Orthologs for PVT1 Gene

Paralogs for PVT1 Gene

No data available for Paralogs for PVT1 Gene

Variants for PVT1 Gene

Sequence variations from dbSNP and Humsavar for PVT1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs11604 -- 128,096,577(+) AGGAA(C/T)GCTTG nc-transcript-variant
rs14949 -- 128,079,120(-) TTCAA(A/G)ATGGT intron-variant
rs874420 -- 127,966,580(-) GTTCA(C/G)GTTAC intron-variant
rs741460 -- 128,056,857(+) TGCTT(C/G)CCCCA intron-variant
rs752427 -- 127,967,762(-) TGGAT(A/G)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PVT1 Gene

Variant ID Type Subtype PubMed ID
nsv7419 OTHER Inversion 18451855
nsv499795 OTHER Inversion 21111241
esv2752208 CNV Gain 17911159
nsv831458 CNV Loss 17160897
esv1251292 CNV Insertion 17803354
esv988546 CNV Insertion 20482838
nsv397550 CNV Insertion 16902084
esv1348770 CNV Insertion 17803354
nsv396423 CNV Insertion 16902084
esv2668349 CNV Deletion 23128226
nsv520172 CNV Loss 19592680
nsv524801 CNV Loss 19592680
esv2662809 CNV Deletion 23128226
esv2538862 CNV Deletion 19546169
nsv523895 CNV Loss 19592680
nsv6388 CNV Loss 18451855

Relevant External Links for PVT1 Gene

HapMap Linkage Disequilibrium report
PVT1
Human Gene Mutation Database (HGMD)
PVT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PVT1 Gene

Disorders for PVT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PVT1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
plasmacytoma
  • myeloma - solitary
- elite association - COSMIC cancer census association via MalaCards
Search PVT1 in MalaCards View complete list of genes associated with diseases

Genatlas disease for PVT1 Gene

Burkitt lymphoma variant/acute lymphoblastic leukemia with translocations t(2;8)(p12;q24);t(8;22)(q24;q11)

Relevant External Links for PVT1

Genetic Association Database (GAD)
PVT1
Human Genome Epidemiology (HuGE) Navigator
PVT1
Tumor Gene Database (TGDB):
PVT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PVT1
genes like me logo Genes that share disorders with PVT1: view

No data available for UniProtKB/Swiss-Prot for PVT1 Gene

Publications for PVT1 Gene

  1. The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells. (PMID: 17503467) Carramusa L. … Feo S. (J. Cell. Physiol. 2007) 2 3 23 67
  2. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao W.J. … Zhang Z.Y. (World J. Gastroenterol. 2013) 2 3
  3. Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance. (PMID: 25956062) Zhang X.W. … Li J. (Biochem. Biophys. Res. Commun. 2015) 3
  4. Long non-coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients. (PMID: 25624916) Ding C. … Zheng S. (Oncol Lett 2015) 3
  5. Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function. (PMID: 25864709) Cabanski C.R. … Maher C.A. (RNA Biol 2015) 3

Products for PVT1 Gene

Sources for PVT1 Gene

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