V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

PVT1 Gene

RNA gene   GIFtS: 38

GC08P128876
Pvt1 oncogene (non-protein coding)
(Previous names: pvt-1 (murine) oncogene homolog, MYC activator, Pvt1 oncogene homolog (mouse) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
MGC21751 2
NCRNA00079 1, 2
Descriptions
Pvt1 oncogene (non-protein coding) 2
Pvt1 oncogene homolog (mouse) 1
pvt-1 (murine) oncogene homolog, MYC activator 1
External Ids
HGNC: 97091
Entrez Gene: 58202
Search outside databases for aliases for PVT1 gene

Previous GC identifers: GC08P127815 GC08U900029 GC08P128764

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for PVT1
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PVT1 gene  

Entrez Gene cytogenetic band: 8q24   HGNC cytogenetic band: 8q24

PVT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P128876:     (about GC identifiers)

Start:
128,875,961 bp from pter
End:
129,182,681 bp from pter
Size:
306,721 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000008.9  NT_008046.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

Antibodies for PVT1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for PVT1

Assays for PVT1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

  --
(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for PVT1

              Sigma-Aldrich siRNA for PVT1  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NR_003367

Genatlas biochemistry entry for PVT1:
plasmocytoma variant translocation (pvt-1) mouse oncogene homolog,c-myc activator (260kb,3') same
as Mis1/MLVI-1

1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pvt1):

no phenotypic analysis

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  PVT1 

  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PVT1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for PVT1  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  


                Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Additional cDNA sequence: AK128687.1 

24/25 DOTS entries (see all 25 ):

DT.92004143  DT.92017456  DT.452872  DT.100779410  DT.92420191  DT.40111387  DT.95185627  DT.97830246 
DT.414396  DT.121477449  DT.75101474  DT.75126784  DT.100699292  DT.409587  DT.91988834  DT.95212182 
DT.95370760  DT.92423888  DT.97842278  DT.423212  DT.91955257  DT.92423883  DT.97842279  DT.100739032 

24/145 AceView cDNA sequences (see all 145 ):

BM804818 BM562579 BM781929 BC033263 BC041065 BX104741 BM845333 AI652658 
AL556447 CA414499 BX280136 CB104922 BM553007 BM824860 BM809411 CA502872 
BE879405 BM821521 CA421444 BM424250 BQ008426 AI498125 BF732344 BX648921 

highest scoring ESTs for PVT1:

AA586695 M34428 AI498125 AI652658 AL556447 BF772948 BI830530 BC033263 BC041065 AA523800 

Unigene Clusters for PVT1:

Pvt1 oncogene (non-protein coding)
Hs.133107  [show with all ESTs], Hs.675281  [show with all ESTs]
Unigene Representative Sequences: BX648921, AK128687


GeneLoc Exon Structure

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PVT1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for PVT1

1 / 2 / 3

10 probe-sets matching PVT1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

79527_s_at2, 3 U95-D 1 1.00 1.00 0.04 0.50 AI185700 0.40 1.00 0.76 1
48676_at2, 3 U95-C 1 1.00 1.00 0.92 1.17 AL046192 0.60 1.00 0.82 1
34060_g_at2, 3 U95-A 1 1.00 1.00 0.83 1.15 AA586695 1.00 1.00 1.00 1

34061_at2, 3 U95-A 1 1.00 1.00 0.34 0.28 M34428 1.00 1.00 1.00 1

69507_at2, 3 U95-E 1 0.94 1.00 0.43 0.69 AI652658 0.80 1.00 0.91 1

34059_at2, 3 U95-A 1 0.88 1.00 0.41 0.36 AA586695 1.00 1.00 1.00 1

216240_at2, 3 U133-A 1 1.00 1.00 -- -- M34428 1.00 1.00 1.00 1

1562153_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1558290_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

216240_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  PVT1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCCAGGTCTG

SOURCE GeneReport for Unigene clusters: Hs.133107 Hs.675281

Expression variation in blood from EXPOLDB for PVT1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for PVT1 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
mouse
(Mus musculus)
Pvt15 15 (32.00 cM) plasmacytoma variant translocation 1   -- Z12002 
About this table        Species with no ortholog for PVT1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --
(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 165140

Genatlas disease: PVT1
Burkitt lymphoma variant/acute lymphoblastic leukemia with translocations
t(2;8)(p12;q24);t(8;22)(q24;q11)

Human Genome Epidemiology Navigator: PVT1 (2 documents)
Tumor Gene Database: PVT1

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/12 PubMed articles for PVT1 gene (see all 12 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5820 HGNC: 9709 AceView: PVT1 euGenes: HUgn5820 ECgene: PVT1
H-InvDB: PVT1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for PVT1 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for PVT1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for PVT1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for PVT1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Search for Recombinant Proteins
 Search for Antibodies
 Search for Chimera RNAi
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Search for Recombinant Proteins
 Search for Antibodies
 Search OriGene for PVT1
 Search Tocris compounds for PVT1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for PVT1

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PVT1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com