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Aliases for PVT1 Gene

Subcategory (RNA class) for PVT1 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for PVT1 Gene

  • Pvt1 Oncogene (Non-Protein Coding) 2 3
  • Pvt-1 (Murine) Oncogene Homolog, MYC Activator 2 3
  • Long Intergenic Non-Protein Coding RNA 79 2 3
  • Plasmacytoma Variant Translocation 1 3
  • Oncogene PVT-1 (MYC Activator) 3
  • Pvt1 Oncogene Homolog (Mouse) 2
  • Non-Protein Coding RNA 79 2
  • Onco-LncRNA-100 3
  • NCRNA00079 3
  • LINC00079 3

External Ids for PVT1 Gene

Previous GeneCards Identifiers for PVT1 Gene

  • GC08P127815
  • GC08U900029
  • GC08P128764
  • GC08P128876
  • GC08P128879
  • GC08P128807
  • GC08P124129
  • GC08P127797

Summaries for PVT1 Gene

Entrez Gene Summary for PVT1 Gene

  • This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]

GeneCards Summary for PVT1 Gene

PVT1 (Pvt1 Oncogene (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with PVT1 include plasmacytoma and plasma cell neoplasm.

Gene Wiki entry for PVT1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PVT1 Gene

Genomics for PVT1 Gene

Regulatory Elements for PVT1 Gene

Genomic Location for PVT1 Gene

Chromosome:
8
Start:
127,794,533 bp from pter
End:
128,101,253 bp from pter
Size:
306,721 bases
Orientation:
Plus strand

Genomic View for PVT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PVT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PVT1 Gene

Proteins for PVT1 Gene

Post-translational modifications for PVT1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PVT1 Gene

Domains & Families for PVT1 Gene

Gene Families for PVT1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PVT1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PVT1 Gene

Function for PVT1 Gene

Molecular function for PVT1 Gene

GENATLAS Biochemistry:
plasmocytoma variant translocation (pvt-1) mouse oncogene homolog,c-myc activator (260kb,3) same as Mis1/MLVI-1

Phenotypes for PVT1 Gene

MGI mutant phenotypes for PVT1:
inferred from 1 alleles
GenomeRNAi human phenotypes for PVT1:
genes like me logo Genes that share phenotypes with PVT1: view

miRNA for PVT1 Gene

miRTarBase miRNAs that target PVT1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for PVT1 Gene

Localization for PVT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PVT1 Gene COMPARTMENTS Subcellular localization image for PVT1 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PVT1 Gene

Pathways & Interactions for PVT1 Gene

SuperPathways for PVT1 Gene

No Data Available

Interacting Proteins for PVT1 Gene

Gene Ontology (GO) - Biological Process for PVT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PVT1 Gene

Drugs & Compounds for PVT1 Gene

No Compound Related Data Available

Transcripts for PVT1 Gene

Unigene Clusters for PVT1 Gene

Pvt1 oncogene (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PVT1 Gene

No ASD Table

Relevant External Links for PVT1 Gene

GeneLoc Exon Structure for
PVT1
ECgene alternative splicing isoforms for
PVT1

Expression for PVT1 Gene

mRNA expression in normal human tissues for PVT1 Gene

SOURCE GeneReport for Unigene cluster for PVT1 Gene Hs.133107

genes like me logo Genes that share expression patterns with PVT1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PVT1 Gene

Orthologs for PVT1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for PVT1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Pvt1 16
Species with no ortholog for PVT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PVT1 Gene

ENSEMBL:
Gene Tree for PVT1 (if available)
TreeFam:
Gene Tree for PVT1 (if available)

Paralogs for PVT1 Gene

No data available for Paralogs for PVT1 Gene

Variants for PVT1 Gene

Sequence variations from dbSNP and Humsavar for PVT1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs10453 -- 128,101,127(-) tgggg(A/G)tggac nc-transcript-variant
rs11604 -- 128,096,577(+) AGGAA(C/T)GCTTG nc-transcript-variant
rs14949 -- 128,079,120(-) TTCAA(A/G)ATGGT intron-variant
rs15626 -- 128,079,046(-) TTGGA(A/G)ATCAC intron-variant
rs730255 -- 127,990,214(+) CTGGA(C/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PVT1 Gene

Variant ID Type Subtype PubMed ID
nsv7419 OTHER Inversion 18451855
nsv499795 OTHER Inversion 21111241
esv2752208 CNV Gain 17911159
nsv831458 CNV Loss 17160897
esv1251292 CNV Insertion 17803354
esv988546 CNV Insertion 20482838
nsv397550 CNV Insertion 16902084
esv1348770 CNV Insertion 17803354
nsv396423 CNV Insertion 16902084
esv2668349 CNV Deletion 23128226
nsv520172 CNV Loss 19592680
nsv524801 CNV Loss 19592680
esv2662809 CNV Deletion 23128226
esv2538862 CNV Deletion 19546169
nsv523895 CNV Loss 19592680
nsv6388 CNV Loss 18451855

Relevant External Links for PVT1 Gene

HapMap Linkage Disequilibrium report
PVT1
Human Gene Mutation Database (HGMD)
PVT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PVT1 Gene

Disorders for PVT1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PVT1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
plasmacytoma
  • myeloma - solitary
plasma cell neoplasm
  • plasmacytic tumor
mature b-cell neoplasm
  • mature b-cell lymphocytic neoplasm
burkitt lymphoma
  • burkitt's lymphoma
- elite association
Search PVT1 in MalaCards View complete list of genes associated with diseases

Genatlas disease for PVT1 Gene

Burkitt lymphoma variant/acute lymphoblastic leukemia with translocations t(2;8)(p12;q24);t(8;22)(q24;q11)

Relevant External Links for PVT1

Genetic Association Database (GAD)
PVT1
Human Genome Epidemiology (HuGE) Navigator
PVT1
Tumor Gene Database (TGDB):
PVT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PVT1
genes like me logo Genes that share disorders with PVT1: view

No data available for UniProtKB/Swiss-Prot for PVT1 Gene

Publications for PVT1 Gene

  1. The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells. (PMID: 17503467) Carramusa L. … Feo S. (J. Cell. Physiol. 2007) 2 23 67
  2. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao W.J. … Zhang Z.Y. (World J. Gastroenterol. 2013) 2 67
  3. Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes, apoptotic/antiapoptotic genes and cell proliferation factors (microarray study). (PMID: 15251464) Zhelev Z. … Baba Y. (FEBS Lett. 2004) 23 67
  4. Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function. (PMID: 25864709) Cabanski C.R. … Maher C.A. (RNA Biol 2015) 67
  5. Long non-coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients. (PMID: 25624916) Ding C. … Zheng S. (Oncol Lett 2015) 67

Products for PVT1 Gene

Sources for PVT1 Gene

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