Aliases for PVRL4 Gene
External Ids for PVRL4 Gene
Previous GeneCards Identifiers for PVRL4 Gene
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
GeneCards Summary for PVRL4 Gene
PVRL4 (Poliovirus Receptor-Related 4) is a Protein Coding gene. Diseases associated with PVRL4 include ectodermal dysplasia-syndactyly syndrome 1 and ectodermal dysplasia - syndactyly syndrome. Among its related pathways are PAK Pathway and Adherens junction. An important paralog of this gene is PVRL3.
UniProtKB/Swiss-Prot for PVRL4 Gene
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells