Aliases for PVRL3 Gene
External Ids for PVRL3 Gene
Previous GeneCards Identifiers for PVRL3 Gene
This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for PVRL3 Gene
PVRL3 (Poliovirus Receptor-Related 3) is a Protein Coding gene. Diseases associated with PVRL3 include megaesophagus. Among its related pathways are PAK Pathway and Adherens junction. GO annotations related to this gene include protein homodimerization activity and cell adhesion molecule binding. An important paralog of this gene is PVRL2.
UniProtKB/Swiss-Prot for PVRL3 Gene
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.