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Aliases for PVRL3 Gene

Aliases for PVRL3 Gene

  • Poliovirus Receptor-Related 3 2 3
  • Poliovirus Receptor-Related Protein 3 3 4
  • CDW113 3 4
  • PRR3 3 4
  • CD113 Antigen 4
  • Nectin 3 3
  • NECTIN-3 3
  • CD113 3
  • PVRR3 3
  • PPR3 3

External Ids for PVRL3 Gene

Previous GeneCards Identifiers for PVRL3 Gene

  • GC03U990126
  • GC03P110361
  • GC03P112071
  • GC00U914371
  • GC03P112112
  • GC03P112273
  • GC03P110788
  • GC03P108165

Summaries for PVRL3 Gene

Entrez Gene Summary for PVRL3 Gene

  • This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for PVRL3 Gene

PVRL3 (Poliovirus Receptor-Related 3) is a Protein Coding gene. Diseases associated with PVRL3 include megaesophagus. Among its related pathways are PAK Pathway and Adherens junction. GO annotations related to this gene include protein homodimerization activity and cell adhesion molecule binding. An important paralog of this gene is PVRL2.

UniProtKB/Swiss-Prot for PVRL3 Gene

  • Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Gene Wiki entry for PVRL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PVRL3 Gene

Genomics for PVRL3 Gene

Regulatory Elements for PVRL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PVRL3 Gene

Chromosome:
3
Start:
111,070,071 bp from pter
End:
111,275,563 bp from pter
Size:
205,493 bases
Orientation:
Plus strand

Genomic View for PVRL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PVRL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PVRL3 Gene

Proteins for PVRL3 Gene

  • Protein details for PVRL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQS3-PVRL3_HUMAN
    Recommended name:
    Nectin-3
    Protein Accession:
    Q9NQS3
    Secondary Accessions:
    • E9PFR0
    • Q6NVZ3
    • Q8NC05
    • Q8WVU4
    • Q9BVA9
    • Q9Y412

    Protein attributes for PVRL3 Gene

    Size:
    549 amino acids
    Molecular mass:
    61002 Da
    Quaternary structure:
    • Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between PVRL1 and PVRL3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with MLLT4/afadin, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT.
    SequenceCaution:
    • Sequence=AAH17572.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PVRL3 Gene

    Alternative splice isoforms for PVRL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PVRL3 Gene

Proteomics data for PVRL3 Gene at MOPED

Post-translational modifications for PVRL3 Gene

  • Glycosylation at Asn 73, Asn 83, Asn 125, Asn 186, Asn 222, and Asn 331
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for PVRL3

No data available for DME Specific Peptides for PVRL3 Gene

Domains & Families for PVRL3 Gene

Protein Domains for PVRL3 Gene

Suggested Antigen Peptide Sequences for PVRL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQS3

UniProtKB/Swiss-Prot:

PVRL3_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the nectin family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with PVRL3: view

Function for PVRL3 Gene

Molecular function for PVRL3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Gene Ontology (GO) - Molecular Function for PVRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 19011627
GO:0042803 protein homodimerization activity ISS --
GO:0050839 cell adhesion molecule binding IPI 12438620
genes like me logo Genes that share ontologies with PVRL3: view
genes like me logo Genes that share phenotypes with PVRL3: view

Animal Models for PVRL3 Gene

MGI Knock Outs for PVRL3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PVRL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PVRL3 Gene

Localization for PVRL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PVRL3 Gene

Cell membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PVRL3 Gene COMPARTMENTS Subcellular localization image for PVRL3 gene
Compartment Confidence
cytoskeleton 3
plasma membrane 3
nucleus 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for PVRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005911 cell-cell junction --
GO:0005913 cell-cell adherens junction IBA --
GO:0043296 apical junction complex IBA --
genes like me logo Genes that share ontologies with PVRL3: view

Pathways & Interactions for PVRL3 Gene

genes like me logo Genes that share pathways with PVRL3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cell Junction PathwayFinder in human,mouse,rat
    • Adherens Junctions in human,mouse,rat

Gene Ontology (GO) - Biological Process for PVRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002089 lens morphogenesis in camera-type eye IEA --
GO:0007155 cell adhesion --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
genes like me logo Genes that share ontologies with PVRL3: view

No data available for SIGNOR curated interactions for PVRL3 Gene

Drugs & Compounds for PVRL3 Gene

No Compound Related Data Available

Transcripts for PVRL3 Gene

Unigene Clusters for PVRL3 Gene

Poliovirus receptor-related 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PVRL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PVRL3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - -
SP7:
SP8: - - - - -

Relevant External Links for PVRL3 Gene

GeneLoc Exon Structure for
PVRL3
ECgene alternative splicing isoforms for
PVRL3

Expression for PVRL3 Gene

mRNA expression in normal human tissues for PVRL3 Gene

mRNA differential expression in normal tissues according to GTEx for PVRL3 Gene

This gene is overexpressed in Testis (x4.5).

Protein differential expression in normal tissues from HIPED for PVRL3 Gene

This gene is overexpressed in Placenta (40.2), Liver (8.9), Testis (8.0), and Fetal Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PVRL3 Gene



SOURCE GeneReport for Unigene cluster for PVRL3 Gene Hs.293917

mRNA Expression by UniProt/SwissProt for PVRL3 Gene

Q9NQS3-PVRL3_HUMAN
Tissue specificity: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
genes like me logo Genes that share expression patterns with PVRL3: view

Protein tissue co-expression partners for PVRL3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PVRL3 Gene

Orthologs for PVRL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PVRL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PVRL3 35
  • 92.25 (n)
  • 93.86 (a)
PVRL3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PVRL3 35
  • 93.84 (n)
  • 95.65 (a)
PVRL3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pvrl3 35
  • 87.78 (n)
  • 88.91 (a)
Pvrl3 16
Pvrl3 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pvrl3 35
  • 87.18 (n)
  • 89.74 (a)
oppossum
(Monodelphis domestica)
Mammalia PVRL3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PVRL3 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PVRL3 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves PVRL3 35
  • 73.54 (n)
  • 70 (a)
PVRL3 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PVRL3 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12547 35
zebrafish
(Danio rerio)
Actinopterygii PVRL3 (2 of 2) 36
  • 38 (a)
OneToMany
pvrl3b 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for PVRL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PVRL3 Gene

ENSEMBL:
Gene Tree for PVRL3 (if available)
TreeFam:
Gene Tree for PVRL3 (if available)

Paralogs for PVRL3 Gene

Paralogs for PVRL3 Gene

(5) SIMAP similar genes for PVRL3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PVRL3: view

Variants for PVRL3 Gene

Sequence variations from dbSNP and Humsavar for PVRL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1370 -- 111,135,227(+) TTAGA(C/G)TAAAC utr-variant-3-prime, intron-variant
rs11202 -- 111,136,452(-) TTTGC(A/C)AAATG utr-variant-3-prime, intron-variant
rs15611 - 111,133,860(-) ACGTC(A/C/G/T)GTCTT utr-variant-3-prime, intron-variant, missense, reference, nc-transcript-variant
rs717160 -- 111,092,704(+) tttta(A/G)tcact intron-variant
rs959352 -- 111,250,916(+) TAAGA(C/T)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PVRL3 Gene

Variant ID Type Subtype PubMed ID
nsv460821 CNV Gain 19166990
esv2658467 CNV Deletion 23128226
esv2725772 CNV Deletion 23290073
esv271123 CNV Insertion 20981092
nsv877338 CNV Loss 21882294
esv2676144 CNV Deletion 23128226
nsv829675 CNV Gain 17160897
nsv877339 CNV Gain 21882294

Variation tolerance for PVRL3 Gene

Residual Variation Intolerance Score: 23.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PVRL3 Gene

HapMap Linkage Disequilibrium report
PVRL3
Human Gene Mutation Database (HGMD)
PVRL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PVRL3 Gene

Disorders for PVRL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PVRL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
megaesophagus
  • esophageal achalasia
- elite association
Search PVRL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PVRL3

Genetic Association Database (GAD)
PVRL3
Human Genome Epidemiology (HuGE) Navigator
PVRL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PVRL3
genes like me logo Genes that share disorders with PVRL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PVRL3 Gene

Publications for PVRL3 Gene

  1. Altered expression of nectin-like adhesion molecules in the peripheral nerve after sciatic nerve transection. (PMID: 18977278) Zelano J. … Cullheim S. (Neurosci. Lett. 2009) 23 67
  2. Novel subtype-specific genes identify distinct subpopulations of callosal projection neurons. (PMID: 19793993) Molyneaux B.J. … Macklis J.D. (J. Neurosci. 2009) 23 67
  3. Roles of cell adhesion molecules nectin and nectin-like molecule-5 in the regulation of cell movement and proliferation. (PMID: 18755001) Ogita H. … Takai Y. (J Microsc 2008) 23 67
  4. Novel role of nectin: implication in the co-localization of JAM-A and claudin-1 at the same cell-cell adhesion membrane domain. (PMID: 18547333) Kuramitsu K. … Takai Y. (Genes Cells 2008) 23 67
  5. Activation of Rap1, Cdc42, and rac by nectin adhesion system. (PMID: 16472674) Ogita H. … Takai Y. (Meth. Enzymol. 2006) 23 67

Products for PVRL3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Adherens Junctions in human,mouse,rat
    • Cell Junction PathwayFinder in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PVRL3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PVRL3
    • Block miRNA regulation of PVRL3 using miScript Target Protectors

    Sources for PVRL3 Gene

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