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PVRL3 Gene

protein-coding   GIFtS: 65
GCID: GC03P110788

Poliovirus Receptor-Related 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Poliovirus Receptor-Related 31 2     PVRR32
PRR32 3 5     Nectin 32
CD1132     Poliovirus Receptor-Related Protein 32
CDW1132     CDw1133
NECTIN-32     Nectin-33
PPR32     CD113 Antigen3

External Ids:    HGNC: 176641   Entrez Gene: 259452   Ensembl: ENSG000001777077   OMIM: 6071475   UniProtKB: Q9NQS33   

Export aliases for PVRL3 gene to outside databases

Previous GC identifers: GC03U990126 GC03P110361 GC03P112071 GC00U914371 GC03P112112 GC03P112273 GC03P108165


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PVRL3 Gene:
This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens
junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous
actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This
gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result
in congenital ocular defects. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Aug 2011)

GeneCards Summary for PVRL3 Gene:
PVRL3 (poliovirus receptor-related 3) is a protein-coding gene. GO annotations related to this gene include protein homodimerization activity and cell adhesion molecule binding. An important paralog of this gene is PVR.

UniProtKB/Swiss-Prot: PVRL3_HUMAN, Q9NQS3
Function: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or
nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR
induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1.
Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces
endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and
proliferation. Plays a role in the morphology of the ciliary body

Gene Wiki entry for PVRL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PVRL3 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   Nkx2-2   POU3F2 (N-Oct-5a)   Nkx3-1 v1   POU3F2   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPVRL3 promoter sequence
   Search Chromatin IP Primers for PVRL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PVRL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13   Ensembl cytogenetic band:  3q13.13   HGNC cytogenetic band: 3q13

PVRL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PVRL3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P110788:  view genomic region     (about GC identifiers)

Start:
110,788,918 bp from pter      End:
110,994,410 bp from pter
Size:
205,493 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PVRL3_HUMAN, Q9NQS3 (See protein sequence)
Recommended Name: Poliovirus receptor-related protein 3 precursor  
Size: 549 amino acids; 61002 Da
Subunit: Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR,
IGSF4B/Necl-1 and with IGSF4. Interacts with MLLT4/afadin. Binds with low affinity to TIGIT
Sequence caution: Sequence=AAH17572.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for PVRL3:
4FOM (3D)    
Secondary accessions: E9PFR0 Q6NVZ3 Q8NC05 Q8WVU4 Q9BVA9 Q9Y412
Alternative splicing: 3 isoforms:  Q9NQS3-1   Q9NQS3-2   Q9NQS3-3   (Ref.2 (BAC11404) sequence differs from that shown at position 268 due to erroneous termination (Translated as Cys))

Explore the universe of human proteins at neXtProt for PVRL3: NX_Q9NQS3

Explore proteomics data for PVRL3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn73, Asn83, Asn125, Asn186, Asn222, Asn331
  • Modification sites at PhosphoSitePlus

  • See PVRL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230215.1  NP_001230217.1  NP_056295.1  

    ENSEMBL proteins: 
     ENSP00000418691   ENSP00000418327   ENSP00000418070   ENSP00000321514   ENSP00000417572  
     ENSP00000420579   ENSP00000420479   ENSP00000419829  
    Reactome Protein details: Q9NQS3

    PVRL3 Human Recombinant Protein Products:

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    antibodies-online proteins for PVRL3 (16 products) 

     
    antibodies-online peptides for PVRL3

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    antibodies-online antibodies for PVRL3 (67 products) 

    PVRL3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9NQS3

    ProtoNet protein and cluster: Q9NQS3

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PVRL3_HUMAN, Q9NQS3
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with PVRL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PVRL3_HUMAN, Q9NQS3
    Function: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or
    nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR
    induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1.
    Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces
    endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and
    proliferation. Plays a role in the morphology of the ciliary body

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19011627
    GO:0042803protein homodimerization activity ISS--
    GO:0050839cell adhesion molecule binding IPI12438620
         
    Find genes that share ontologies with PVRL3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PVRL3:
     Large nuclei 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pvrl3):
     behavior/neurological  craniofacial  homeostasis/metabolism  integument  mortality/aging 
     reproductive system  vision/eye 

    Find genes that share phenotypes with PVRL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pvrl3tm1Ytk for PVRL3

       genOway: Develop your customized and physiologically relevant rodent model for PVRL3

    miRNA
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    miRTarBase miRNAs that target PVRL3:
    hsa-mir-615-3p (MIRT039697), hsa-mir-186-5p (MIRT021153), hsa-mir-34a-5p (MIRT047367), hsa-mir-16-5p (MIRT031995), hsa-mir-27b-3p (MIRT046209)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PVRL3_HUMAN, Q9NQS3: Cell membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction ----
    GO:0005913cell-cell adherens junction IEA--
    GO:0016021integral component of membrane IEA--
    GO:0043296apical junction complex IEA--

    Find genes that share ontologies with PVRL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PVRL3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Adherens junctions interactions0.49
    Cell-cell junction organization0.70
    Nectin/Necl trans heterodimerization0.00
    Cell-Cell communication0.64
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    3PAK Pathway
    Epithelial Adherens Junctions0.36
    4Nectin adhesion pathway
    Nectin adhesion pathway
    5Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with PVRL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PVRL3
        Sertoli-Sertoli Cell Junction Dynamics
    Germ Cell-Sertoli Cell Junction Dynamics
    Epithelial Adherens Junctions

    1 BioSystems Pathway for PVRL3
        Nectin adhesion pathway


    2 Reactome Pathways for PVRL3
        Adherens junctions interactions
    Nectin/Necl trans heterodimerization


    2 Kegg Pathways  (Kegg details for PVRL3):
        Cell adhesion molecules (CAMs)
    Adherens junction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PVRL3: 
              Adherens Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PVRL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for PVRL3 (Q9NQS31, 2, 3 ENSP000004180704) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PVRL2Q926921, 3, ENSP000002524834EBI-2826725,EBI-718419 I2D: score=3 STRING: ENSP00000252483
    MLLT4P551962, 3, ENSP000003836234MINT-73129 MINT-58417 MINT-58408 MINT-73128 I2D: score=2 STRING: ENSP00000383623
    PVRL1Q152231, 2, 3, ENSP000002640254EBI-2826725,EBI-1771314 MINT-49748 I2D: score=3 STRING: ENSP00000264025
    PARD3Q8TEW03, ENSP000003639214I2D: score=5 STRING: ENSP00000363921
    PVRP151513, ENSP000004020604I2D: score=2 STRING: ENSP00000402060
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002089lens morphogenesis in camera-type eye IEA--
    GO:0007155cell adhesion ----
    GO:0007156homophilic cell adhesion ISS--
    GO:0009566fertilization IEA--
    GO:0016337cell-cell adhesion ----

    Find genes that share ontologies with PVRL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PVRL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PVRL3 gene (3 alternative transcripts): 
    NM_001243286.1  NM_001243288.1  NM_015480.2  

    Unigene Cluster for PVRL3:

    Poliovirus receptor-related 3
    Hs.293917  [show with all ESTs]
    Unigene Representative Sequence: NM_015480
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491525 ENST00000461477 ENST00000485303(uc003dxt.2 uc021xch.1)
    ENST00000319792 ENST00000486596 ENST00000493615(uc003dxu.2) ENST00000488016
    ENST00000470618 ENST00000481766 ENST00000478327 ENST00000485506
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    Additional mRNA sequence: 

    AF282874.1 AL050071.1 BC001336.1 BC017572.1 BC067808.1 

    9 DOTS entries:

    DT.441999  DT.91921059  DT.40258614  DT.95241548  DT.91728308  DT.75184263  DT.99953577  DT.99981494 
    DT.75122403 

    Selected AceView cDNA sequences (see all 159):

    BG167996 BX093819 AF282874 AI684680 AI741566 BF513184 AL043329 AA643517 
    CA445313 BC001336 BP335614 AA723758 BF965834 CD672749 AI886090 NM_015480 
    AA555086 BI829271 H01458 BQ023727 AA406320 BI828380 AI677836 CB128771 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PVRL3 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                -     -     -     -     -     -                                                           -     -                           
    SP2:                          -     -     -     -     -     -     -                                                           -                                 
    SP3:                          -     -     -     -     -     -     -                                                                                             
    SP4:                                                  -           -                                                                                             
    SP5:        -     -     -     -     -     -     -     -     -     -                                                                                             


    ECgene alternative splicing isoforms for PVRL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PVRL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAAAGTTC
    PVRL3 Expression
    About this image


    PVRL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Diencephalic Roof Plate
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebellum
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Mature Endothelial Cells Corneal Endothelium
             Human umbilical vein endothelial cells (HUVEC)
    PVRL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PVRL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.293917

    UniProtKB/Swiss-Prot: PVRL3_HUMAN, Q9NQS3
    Tissue specificity: Predominantly expressed in testis and placenta as well as in many cell lines, including
    epithelial cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PVRL3: 
              Adherens Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PVRL3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pvrl31 , 5 poliovirus receptor-related 31, 5 87.78(n)1
    88.91(a)1
      16 (30.48 cM)5
    589981  NM_021496.31  NP_067471.11 
     463877065 
    chicken
    (Gallus gallus)
    Aves PVRL31 poliovirus receptor-related 3 73.54(n)
    70(a)
      418415  XM_416630.4  XP_416630.3 
    lizard
    (Anolis carolinensis)
    Reptilia PVRL36
    poliovirus receptor-related 3
    70(a)
    1 ↔ 1
    3(168236503-168265898)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.125472 Transcribed sequence with weak similarity to protein more 74.74(n)    BX710060.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pvrl3b6
    PVRL3 (2 of 2)6
    poliovirus receptor-related 3
    38(a)
    38(a)
    1 ↔ many
    1 ↔ many
    21(20336190-20402660) ENSDARG00000006604
    8(5751021-5858581) ENSDARG00000057399


    ENSEMBL Gene Tree for PVRL3 (if available)
    TreeFam Gene Tree for PVRL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PVRL3 gene
    PVR2  PVRL22  PVRL12  PVRL42  
    5 SIMAP similar genes for PVRL3 using alignment to 6 protein entries:     PVRL3_HUMAN (see all proteins):
    PVRL2    CD226    CD96    PVRL1    PVRL4

    Find genes that share paralogs with PVRL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PVRL3 (see all 2213)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs717362411,2
    C--108183662(+) TTGTT-/TGTGTGT 3 -- int10--------
    rs113577171,2
    C--108183789(+) AGTTT-/TCCATC 3 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs757857491,2
    C--108185685(+) CAGTA-/CTGTT 
            
    CTGTT
    3 -- int10--------
    rs784778331,2
    --108185688(+) ACTGTA/TCTGTT 3 -- int10--------
    rs1139027481,2
    C--108204924(+) GTGCA-/TGT   
       GTGTG
    TGTGT
    3 -- int11Minor allele frequency- TGTGTGTG:0.50CSA 2
    rs602763601,2
    C--108229117(+) AACGA-/TGAGGTGG 3 -- cds1 int10--------
    rs14778391,2
    C--108264862(+) CACTCC/TATTAT 1 -- int10--------
    rs1386810851,2
    --110757600(+) GAAAAC/TCTGGA 2 -- us2k10--------
    rs1427333031,2
    --110757625(+) TAGTGA/GTATTA 2 -- us2k10--------
    rs1926613621,2
    C--110757712(+) GCTGCA/G/TCAGTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PVRL3 (110788918 - 110994410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PVRL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676144CNV Deletion23128226
    esv2725772CNV Deletion23290073
    esv2658467CNV Deletion23128226
    esv271123CNV Insertion20981092
    nsv877338CNV Loss21882294
    nsv829675CNV Gain17160897
    nsv460821CNV Gain19166990
    nsv877339CNV Gain21882294

    Human Gene Mutation Database (HGMD): PVRL3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PVRL3
    DNA2.0 Custom Variant and Variant Library Synthesis for PVRL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607147    OMIM disorders: --


    Find genes that share disorders with PVRL3           About GenesLikeMe

    Genetic Association Database (GAD): PVRL3
    Human Genome Epidemiology (HuGE) Navigator: PVRL3 (4 documents)

    Export disorders for PVRL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PVRL3 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with PVRL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. (PubMed id 11024295)1, 2, 3 Reymond N.... Lopez M. (Gene 2000)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. (PubMed id 19011627)1, 2 Yu X.... Grogan J.L. (Nat. Immunol. 2009)
    5. Inhibition of cell movement and proliferation by cell-cell contact- induced interaction of Necl-5 with nectin-3. (PubMed id 16216929)1, 2 Fujito T.... Takai Y. (J. Cell Biol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Recruitment of nectin-3 to cell-cell junctions through trans- heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains. (PubMed id 12759359)1, 2 Mueller S. and Wimmer E. (J. Biol. Chem. 2003)
    8. Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. (PubMed id 10744716)1, 9 Satoh-Horikawa K....Takai Y. (J. Biol. Chem. 2000)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. Eutopic endometrium and peritoneal, ovarian and colorectal endometriotic tissues express a different profile of nectin-1, -3, -4 and nectin-like molecule 2. (PubMed id 22926846)1 Ballester M....DaraA^ E. (Hum. Reprod. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25945 HGNC: 17664 AceView: PVRL3 Ensembl:ENSG00000177707 euGenes: HUgn25945
    ECgene: PVRL3 Kegg: 25945 H-InvDB: PVRL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PVRL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PVRL3 gene:
    Search GeneIP for patents involving PVRL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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