Aliases for PVRL2 Gene
External Ids for PVRL2 Gene
Previous HGNC Symbols for PVRL2 Gene
Previous GeneCards Identifiers for PVRL2 Gene
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for PVRL2 Gene
PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B)) is a Protein Coding gene. Diseases associated with PVRL2 include ovarian cystic teratoma and mature teratoma of the ovary. Among its related pathways are Immune System and PAK Pathway. GO annotations related to this gene include protein homodimerization activity and cell adhesion molecule binding. An important paralog of this gene is PVRL3.
UniProtKB/Swiss-Prot for PVRL2 Gene
Probable cell adhesion protein.
(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).