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Aliases for PVRL2 Gene

Aliases for PVRL2 Gene

  • Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) 2 3
  • HVEB 3 4
  • PRR2 3 4
  • Poliovirus Receptor-Related Protein 2 4
  • Herpes Virus Entry Mediator B 4
  • Herpesvirus Entry Mediator B 4
  • Herpesvirus Entry Protein B 3
  • Poliovirus Receptor-Like 2 3
  • CD112 Antigen 4
  • CD112 3
  • PVRR2 3

External Ids for PVRL2 Gene

Previous HGNC Symbols for PVRL2 Gene

  • HVEB

Previous GeneCards Identifiers for PVRL2 Gene

  • GC19P045994
  • GC19P045740
  • GC19P050025
  • GC19P050041
  • GC19P045349
  • GC19P041779

Summaries for PVRL2 Gene

Entrez Gene Summary for PVRL2 Gene

  • This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for PVRL2 Gene

PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B)) is a Protein Coding gene. Diseases associated with PVRL2 include ovarian cystic teratoma and mature teratoma of the ovary. Among its related pathways are Immune System and PAK Pathway. GO annotations related to this gene include protein homodimerization activity and cell adhesion molecule binding. An important paralog of this gene is PVRL3.

UniProtKB/Swiss-Prot for PVRL2 Gene

  • Probable cell adhesion protein.

  • (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Gene Wiki entry for PVRL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PVRL2 Gene

Genomics for PVRL2 Gene

Regulatory Elements for PVRL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PVRL2 Gene

Chromosome:
19
Start:
44,846,136 bp from pter
End:
44,889,228 bp from pter
Size:
43,093 bases
Orientation:
Plus strand

Genomic View for PVRL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PVRL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PVRL2 Gene

Proteins for PVRL2 Gene

  • Protein details for PVRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92692-PVRL2_HUMAN
    Recommended name:
    Nectin-2
    Protein Accession:
    Q92692
    Secondary Accessions:
    • A8K5L5
    • O75455
    • Q6IBI6
    • Q96J29

    Protein attributes for PVRL2 Gene

    Size:
    538 amino acids
    Molecular mass:
    57742 Da
    Quaternary structure:
    • Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Binds with low affinity to TIGIT. (Microbial infection) Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D (PubMed:11602758, PubMed:9657005).

    Three dimensional structures from OCA and Proteopedia for PVRL2 Gene

    Alternative splice isoforms for PVRL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PVRL2 Gene

Proteomics data for PVRL2 Gene at MOPED

Post-translational modifications for PVRL2 Gene

  • Glycosylation at Ser 95, Asn 137, and Asn 324
  • Modification sites at PhosphoSitePlus

Other Protein References for PVRL2 Gene

Antibody Products

  • R&D Systems Antibodies for PVRL2 (Nectin-2/CD112)
  • Cloud-Clone Corp. Antibodies for PVRL2

No data available for DME Specific Peptides for PVRL2 Gene

Domains & Families for PVRL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92692

UniProtKB/Swiss-Prot:

PVRL2_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the nectin family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with PVRL2: view

Function for PVRL2 Gene

Molecular function for PVRL2 Gene

UniProtKB/Swiss-Prot Function:
Probable cell adhesion protein.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Gene Ontology (GO) - Molecular Function for PVRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 16189514
GO:0015026 coreceptor activity TAS 9657005
GO:0042802 identical protein binding IPI 21982860
genes like me logo Genes that share ontologies with PVRL2: view
genes like me logo Genes that share phenotypes with PVRL2: view

Animal Models for PVRL2 Gene

MGI Knock Outs for PVRL2:

Animal Model Products

miRNA for PVRL2 Gene

miRTarBase miRNAs that target PVRL2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PVRL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PVRL2 Gene

Localization for PVRL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PVRL2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PVRL2 Gene COMPARTMENTS Subcellular localization image for PVRL2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for PVRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005911 cell-cell junction IDA 9845526
GO:0005913 cell-cell adherens junction IBA --
GO:0005915 zonula adherens ISS 10225955
genes like me logo Genes that share ontologies with PVRL2: view

Pathways & Interactions for PVRL2 Gene

genes like me logo Genes that share pathways with PVRL2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PVRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP 12913096
GO:0002891 positive regulation of immunoglobulin mediated immune response IMP 16831868
GO:0007010 cytoskeleton organization IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA 9845526
genes like me logo Genes that share ontologies with PVRL2: view

No data available for SIGNOR curated interactions for PVRL2 Gene

Drugs & Compounds for PVRL2 Gene

(2) Drugs for PVRL2 Gene - From: ApexBio and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CMX001 Investigational Pharma Broad spectrum antiviral drug 0
tyrosine Nutra 547

(1) Additional Compounds for PVRL2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
heparan sulfate
  • alpha-Idosane
  • Heparan N-sulfate
  • Heparan N-sulphate
  • Heparan sulfate
  • Heparan sulphate
9050-30-0
genes like me logo Genes that share compounds with PVRL2: view

Transcripts for PVRL2 Gene

Unigene Clusters for PVRL2 Gene

Poliovirus receptor-related 2 (herpesvirus entry mediator B):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PVRL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PVRL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - - -
SP3: -
SP4: - - -
SP5:

Relevant External Links for PVRL2 Gene

GeneLoc Exon Structure for
PVRL2
ECgene alternative splicing isoforms for
PVRL2

Expression for PVRL2 Gene

mRNA expression in normal human tissues for PVRL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PVRL2 Gene

This gene is overexpressed in Nasal epithelium (21.7), Urine (8.6), and Cerebral cortex (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PVRL2 Gene



SOURCE GeneReport for Unigene cluster for PVRL2 Gene Hs.655455

mRNA Expression by UniProt/SwissProt for PVRL2 Gene

Q92692-PVRL2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with PVRL2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PVRL2 Gene

Orthologs for PVRL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PVRL2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PVRL2 35
  • 82.78 (n)
  • 79.37 (a)
PRR2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pvrl2 35
  • 78.32 (n)
  • 75.61 (a)
Pvrl2 16
Pvrl2 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PVRL2 35
  • 99.32 (n)
  • 99.26 (a)
PRR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pvrl2 35
  • 78.39 (n)
  • 75.43 (a)
cow
(Bos Taurus)
Mammalia PVRL2 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch73-22o12.1 36
  • 29 (a)
ManyToMany
pvrl2l 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for PVRL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PVRL2 Gene

ENSEMBL:
Gene Tree for PVRL2 (if available)
TreeFam:
Gene Tree for PVRL2 (if available)

Paralogs for PVRL2 Gene

Paralogs for PVRL2 Gene

(3) SIMAP similar genes for PVRL2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for PVRL2 Gene

genes like me logo Genes that share paralogs with PVRL2: view

Variants for PVRL2 Gene

Sequence variations from dbSNP and Humsavar for PVRL2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs6857 -- 44,888,997(-) CCCTA(A/G)GCTGG utr-variant-3-prime
rs6859 -- 44,878,777(+) GGAAC(A/G)GCACA intron-variant, utr-variant-3-prime
rs166907 -- 44,883,598(-) gagcc(C/T)tggcc intron-variant
rs283808 -- 44,883,777(-) catga(G/T)catag intron-variant
rs283809 -- 44,883,800(-) tcacc(C/T)gggct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PVRL2 Gene

Variant ID Type Subtype PubMed ID
dgv12e24 CNV Gain 17666407
dgv13e24 CNV Loss 17666407
esv2750597 CNV Loss 17666407
dgv3948n71 CNV Loss 21882294
nsv509747 CNV Insertion 20534489
dgv3949n71 CNV Loss 21882294

Variation tolerance for PVRL2 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PVRL2 Gene

HapMap Linkage Disequilibrium report
PVRL2
Human Gene Mutation Database (HGMD)
PVRL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PVRL2 Gene

Disorders for PVRL2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PVRL2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cystic teratoma
mature teratoma of the ovary
  • mature teratoma of ovary
herpes simplex
  • herpesvirus hominis disease
- elite association
Search PVRL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PVRL2

Genetic Association Database (GAD)
PVRL2
Human Genome Epidemiology (HuGE) Navigator
PVRL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PVRL2
genes like me logo Genes that share disorders with PVRL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PVRL2 Gene

Publications for PVRL2 Gene

  1. The murine homolog (Mph) of human herpesvirus entry protein B (HveB) mediates entry of pseudorabies virus but not herpes simplex virus types 1 and 2. (PMID: 10196354) Shukla D. … Spear P.G. (J. Virol. 1999) 2 23 67
  2. The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene. (PMID: 7622062) Eberle F. … Lopez M. (Gene 1995) 2 23 67
  3. Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis. (PMID: 20332149) Morita H. … Ueno N. (Development 2010) 23 67
  4. Expression of adhesion molecules and ligands for activating and costimulatory receptors involved in cell-mediated cytotoxicity in a large panel of human melanoma cell lines. (PMID: 19259667) Casado J.G. … Tarazona R. (Cancer Immunol. Immunother. 2009) 23 67
  5. NK cells recognize and kill human glioblastoma cells with stem cell-like properties. (PMID: 19265131) Castriconi R. … Bottino C. (J. Immunol. 2009) 23 67

Products for PVRL2 Gene

  • Addgene plasmids for PVRL2

Sources for PVRL2 Gene

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