Aliases for PVRL1 Gene
- Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) 2 3
- Poliovirus Receptor-Related Protein 1 3 4
- Herpes Virus Entry Mediator C 3 4
- Herpesvirus Ig-Like Receptor 3 4
- HVEC 3 4
- HIgR 3 4
- PRR1 3 4
- Ectodermal Dysplasia 4 (Margarita Island Type) 3
- Herpes Simplex Virus Type 1 Sensitivity 3
- Herpesvirus Entry Mediator C 4
- Poliovirus Receptor-Like 1 3
- CD111 Antigen 4
- Nectin 1 3
External Ids for PVRL1 Gene
Previous HGNC Symbols for PVRL1 Gene
Previous GeneCards Identifiers for PVRL1 Gene
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
GeneCards Summary for PVRL1 Gene
PVRL1 (Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C)) is a Protein Coding gene. Diseases associated with PVRL1 include zlotogora syndrome and cleft lip/palate-ectodermal dysplasia syndrome. Among its related pathways are PAK Pathway and Adherens junction. GO annotations related to this gene include protein homodimerization activity and receptor activity. An important paralog of this gene is PVR.
UniProtKB/Swiss-Prot for PVRL1 Gene
Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Has some neurite outgrowth-promoting activity.
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.