Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PVRL1 Gene

protein-coding   GIFtS: 66
GCID: GC11M119542

Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator...


(Previous symbols: HVEC, ED4)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C)1 2     PRR2
HVEC1 2 3 5     PVRR2
ED41 2 5     SK-122
PRR12 3 5     Ectodermal Dysplasia 4 (Margarita Island Type)2
Herpes Virus Entry Mediator C2 3     Nectin 12
Herpesvirus Ig-Like Receptor2 3     nectin-12
HIgR2 3     Poliovirus Receptor-Like 12
CLPED12 5     Poliovirus Receptor-Related Protein 12
OFC72 5     HveC3
PVRR12 5     Nectin-13
nectin1     CD111 Antigen3
CD1112     Herpesvirus Entry Mediator C3

External Ids:    HGNC: 97061   Entrez Gene: 58182   Ensembl: ENSG000001104007   OMIM: 6006445   UniProtKB: Q152233   

Export aliases for PVRL1 gene to outside databases

Previous GC identifers: GC11M121534 GC11M121020 GC11M119073 GC11M119046 GC11M119014 GC11M115451


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PVRL1 Gene:
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight
junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion
molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a
single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for
glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates
viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal
dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative
splicing results in multiple transcript variants encoding proteins with distinct C-termini. (provided by RefSeq,
Oct 2009)

GeneCards Summary for PVRL1 Gene: 
PVRL1 (poliovirus receptor-related 1 (herpesvirus entry mediator C)) is a protein-coding gene. Diseases associated with PVRL1 include herpes simplex, and cleft lip, and among its related super-pathways are Cell-cell junction organization and Germ Cell-Sertoli Cell Junction Dynamics. GO annotations related to this gene include protein homodimerization activity and coreceptor activity. An important paralog of this gene is PVR.

UniProtKB/Swiss-Prot: PVRL1_HUMAN, Q15223
Function: Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic
interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and
PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus

Gene Wiki entry for PVRL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PVRL1 gene promoter:
         ATF-2   POU3F1   HNF-4alpha2   HNF-4alpha1   c-Ets-1   CRE-BP1   CREB   deltaCREB   ARP-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PVRL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PVRL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PVRL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23-q24

PVRL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PVRL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M119542:  view genomic region     (about GC identifiers)

Start:
119,494,120 bp from pter      End:
119,599,794 bp from pter
Size:
105,675 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PVRL1_HUMAN, Q15223 (See protein sequence)
Recommended Name: Poliovirus receptor-related protein 1 precursor  
Size: 517 amino acids; 57158 Da
Subunit: Can form trans-heterodimers with PVRL3/nectin-3 and with PVRL4/nectin-4. Interacts (via C-terminus) with
afadin (via PDZ domain); this interaction recruits PVRL1 to cadherin-based adherens junctions. Interacts with
integrin alphaV/beta3. Interacts with herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and
pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses
Subcellular location: Isoform Alpha: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform Delta: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform Gamma: Secreted
Sequence caution: Sequence=CAA53980.2; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for PVRL1:
3ALP (3D)        3SKU (3D)        3U82 (3D)        3U83 (3D)        4FMF (3D)    
Secondary accessions: O75465 Q2M3D3 Q9HBE6 Q9HBW2
Alternative splicing: 3 isoforms:  Q15223-1   Q15223-2   Q15223-3   

Explore the universe of human proteins at neXtProt for PVRL1: NX_Q15223

Explore proteomics data for PVRL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15223

  • PVRL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PVRL1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_002846.3  NP_976030.1  NP_976031.1  

    ENSEMBL proteins: 
     ENSP00000344974   ENSP00000264025   ENSP00000345289  
    Reactome Protein details: Q15223
    Human Recombinant Protein Products for PVRL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PVRL1 (Nectin-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PVRL1
    OriGene Protein Over-expression Lysate for PVRL1
    OriGene MassSpec for PVRL1 
    OriGene Custom Protein Services for PVRL1
    GenScript Custom Purified and Recombinant Proteins Services for PVRL1
    Novus Biologicals PVRL1 Proteins
    Novus Biologicals PVRL1 Lysates
    Sino Biological Recombinant Protein for PVRL1
    Sino Biological Cell Lysate for PVRL1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PVRL1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005912adherens junction NAS12885915
    GO:0005913cell-cell adherens junction IDA10225955
    GO:0016020membrane TAS9616127

    PVRL1 for ontologies           About GeneDecksing



    PVRL1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PVRL1
    R&D Systems Antibodies for PVRL1 (Nectin-1)
    OriGene Antibodies for PVRL1
    OriGene Custom Antibody Services for PVRL1
    GenScript Custom Superior Antibodies Services for PVRL1
    Novus Biologicals PVRL1 Antibodies
    Abcam antibodies for PVRL1
    Cloud-Clone Corp. Antibodies for PVRL1 
    ThermoFisher Antibodies for PVRL1
    LSBio Antibodies in human, mouse, rat for PVRL1 

    Assay Products for PVRL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PVRL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PVRL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PVRL1 
    Cloud-Clone Corp. CLIAs for PVRL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/6 InterPro protein domains (see all 6):
     IPR013162 CD80_C2-set
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q15223

    ProtoNet protein and cluster: Q15223

    2 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PVRL1_HUMAN, Q15223
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    PVRL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PVRL1_HUMAN, Q15223
    Function: Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic
    interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and
    PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI--
    GO:0015026coreceptor activity TAS9616127
    GO:0042803protein homodimerization activity ISS--
         
    PVRL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PVRL1:
     Increased HDAC inhibitor resis 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pvrl1):
     behavior/neurological  craniofacial  growth/size  homeostasis/metabolism  integument 
     mortality/aging  vision/eye 

    PVRL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PVRL1: Pvrl1tm1Ytk Pvrl1tm1Mjd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PVRL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PVRL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PVRL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PVRL1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PVRL1:
    hsa-mir-661 (MIRT004550)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PVRL1
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate PVRL1 (see all 80):
    hsa-miR-124* hsa-miR-642a hsa-miR-4254 hsa-miR-15a hsa-miR-4267 hsa-miR-1273d hsa-miR-3142 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidPVRL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PVRL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PVRL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PVRL1
    Sirion Biotech Customized adenovirus for overexpression of PVRL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PVRL1 (see all 14)
    OriGene ORF clones in mouse, rat for PVRL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PVRL1 (NM_203285)
    Sino Biological Human cDNA Clone for PVRL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PVRL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PVRL1
    Sirion Biotech Customized lentivirus for stable overexpression of PVRL1 
                         Customized lentivirus expression plasmids for stable overexpression of PVRL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PVRL1
    Search LifeMap BioReagents cell lines for PVRL1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PVRL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PVRL1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Adherens junctions interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    3PAK Pathway
    Epithelial Adherens Junctions0.36
    4Influenza A
    Herpes simplex infection0.33
    5Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PVRL1
        Cell adhesion Tight junctions

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PVRL1
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for PVRL1
        Cell adhesion Tight junctions

    1 BioSystems Pathway for PVRL1
        Nectin adhesion pathway


    5        Reactome Pathways for PVRL1
        Adherens junctions interactions
    Nectin/Necl trans heterodimerization
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    3         Kegg Pathways  (Kegg details for PVRL1):
        Cell adhesion molecules (CAMs)
    Adherens junction
    Herpes simplex infection


    PVRL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PVRL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/19 Interacting proteins for PVRL1 (Q152231, 2, 3 ENSP000002640254) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PVRL3Q9NQS31, 2, 3, ENSP000004180704EBI-1771314,EBI-2826725 MINT-49748 I2D: score=3 STRING: ENSP00000418070
    PVRL4Q96NY81, 2, 3, ENSP000003569914EBI-1771314,EBI-4314784 MINT-49749 I2D: score=2 STRING: ENSP00000356991
    MLLT4P551962, 3, ENSP000003836234MINT-58185 MINT-58421 I2D: score=3 STRING: ENSP00000383623
    PARD3Q8TEW03, ENSP000003639214I2D: score=4 STRING: ENSP00000363921
    PVRP151513, ENSP000004020604I2D: score=2 STRING: ENSP00000402060
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002089lens morphogenesis in camera-type eye IEA--
    GO:0002934desmosome organization IEA--
    GO:0006826iron ion transport IEA--
    GO:0006955immune response NAS10932188
    GO:0007155cell adhesion NAS12764381

    PVRL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PVRL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PVRL1

    5 Novoseek inferred chemical compound relationships for PVRL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparan sulfate 47.2 6 12915538 (2), 18803666 (1), 15273289 (1), 16940509 (1) (see all 5)
    12-o-tetradecanoylphorbol 13-acetate 30.8 5 15836772 (2), 10583506 (1)
    gtp 7.63 2 15485841 (1), 15504743 (1)
    tyrosine 5.53 4 15485841 (1), 19196253 (1), 10962558 (1)
    calcium 3.61 5 17525764 (4), 10583506 (1)

    Search CenterWatch for drugs/clinical trials and news about PVRL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PVRL1 gene (4 alternative transcripts): 
    NM_002855.4  NM_203285.1  NM_203286.1  NM_032767.1  

    Unigene Cluster for PVRL1:

    Poliovirus receptor-related 1 (herpesvirus entry mediator C)
    Hs.334846  [show with all ESTs]
    Unigene Representative Sequence: NM_002855
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531468 ENST00000341398(uc001pwu.1) ENST00000264025(uc001pwv.3 uc001pww.3)
    ENST00000524429 ENST00000340882 ENST00000532197 ENST00000524510
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PVRL1
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate PVRL1 (see all 80):
    hsa-miR-124* hsa-miR-642a hsa-miR-4254 hsa-miR-15a hsa-miR-4267 hsa-miR-1273d hsa-miR-3142 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidPVRL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PVRL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PVRL1
    Clone
    Products:
         
    OriGene clones in human, mouse for PVRL1 (see all 14)
    OriGene ORF clones in mouse, rat for PVRL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PVRL1 (NM_203285)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PVRL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PVRL1
    Sirion Biotech Customized lentivirus for stable overexpression of PVRL1 
                         Customized lentivirus expression plasmids for stable overexpression of PVRL1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PVRL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PVRL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PVRL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PVRL1

    Additional mRNA sequence: 

    AF060231.1 AF110314.1 AK056455.1 AK091231.1 AK095375.1 AY029539.1 BC007379.2 BC021976.2 
    BC044230.2 BC064140.1 BC086309.1 BC104948.1 BC113471.1 X76400.2 

    12 DOTS entries:

    DT.453399  DT.95264877  DT.95264879  DT.75141634  DT.95307631  DT.116425  DT.100814104  DT.120716814 
    DT.95307628  DT.97777518  DT.91910166  DT.99977409 

    24/225 AceView cDNA sequences (see all 225):

    AI298771 BG260985 CA311421 AF060231 BM710977 AF110314 T30207 AA443796 
    BX474722 BC007379 BG740999 BM709077 AW366292 BQ941721 BM702011 BP351051 
    AY029539 BQ689558 BU732536 AI961428 CA944513 BF036447 BU729672 AA447786 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PVRL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCTTCCTCT
    PVRL1 Expression
    About this image


    See PVRL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PVRL1

    SOURCE GeneReport for Unigene cluster: Hs.334846
        SABiosciences Expression via Pathway-Focused PCR Arrays including PVRL1: 
              Adherens Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PVRL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PVRL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PVRL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PVRL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PVRL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PVRL1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pvrl11 , 5 poliovirus receptor-related 11, 5 90.61(n)1
    94.95(a)1
      9 (24.42 cM)5
    582351  NM_021424.21  NP_067399.21 
     437445765 
    chicken
    (Gallus gallus)
    Aves LOC1008578751 poliovirus receptor-related protein 1-like 75(n)
    74.4(a)
      100857875  XM_003642591.1  XP_003642639.1 
    lizard
    (Anolis carolinensis)
    Reptilia PVRL16
    --
    Uncharacterized protein
    71(a)
    70(a)
    1 ↔ many
    1 ↔ many
    LGa(477486-479306)
    LGa(448995-452240)
    zebrafish
    (Danio rerio)
    Actinopterygii pvrl1b6
    pvrl1b6
    (see all 3)
    poliovirus receptor-related 1b
    (see all 3)
    58(a)
    54(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    18(41670067-41714861)
    18(41556150-41562341)


    ENSEMBL Gene Tree for PVRL1 (if available)
    TreeFam Gene Tree for PVRL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PVRL1 gene
    PVR2  PVRL22  PVRL42  PVRL32  
    2 SIMAP similar genes for PVRL1 using alignment to 6 protein entries:     PVRL1_HUMAN (see all proteins):
    PVRL2    PVRL3

    PVRL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2010 SNPs in PVRL1 are shown (see all 2010)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048942811,2
    Cpathogenic1119414175(-) ATCCTA/GGGAAA 6 * W stg10--------
    rs113003321,2
    C,F--115451930(+) CCTCA-/GGGGTC 1 -- int13Minor allele frequency- G:0.20NA CSA 10
    rs665411091,2
    C--115455137(+) TCCAC-/CGGG  
            
    CGGGC
    1 -- int11Minor allele frequency- CGGG:0.00CSA 2
    rs357008701,2
    C--115470340(+) GTCTTT/-AAAAA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs3734037681,2
    C--115470467(+) TATAA-/AAT/  
      AATAAT
    AATAA
    3 -- int1 cds10--------
    rs570599761,2
    C--115470505(+) TAATA-/ATA/  
      ATAATA
    CTAGC
    2 -- cds10--------
    rs714709821,2
    C--115470649(+) GTCTCAA/-AAAAA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs106288821,2
    C--115482147(+) gtctcAA/-aaaaa 2 -- int1 trp31Minor allele frequency- -:0.50NA 2
    rs339541611,2
    C--115488747(+) AAAAA-/A/AA  
            
    TAATA
    3 -- int11CSA 2
    rs49387121,2
    A--115509161(+) CGCCCG/TCCCCC 3 -- int10--------

    HapMap Linkage Disequilibrium report for PVRL1 (119494120 - 119599794 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for PVRL1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745129CNV Deletion23290073
    esv2661826CNV Deletion23128226
    esv2745131CNV Deletion23290073
    nsv509445CNV Insertion20534489
    nsv513336CNV Insertion21212237
    nsv898423CNV Loss21882294
    nsv898422CNV Loss21882294
    nsv898420CNV Loss21882294
    nsv898419CNV Loss21882294
    nsv468880CNV Loss19166990


    Human Gene Mutation Database (HGMD): PVRL1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PVRL1
    DNA2.0 Custom Variant and Variant Library Synthesis for PVRL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600644   
    OMIM disorders: 225060  
    UniProtKB/Swiss-Prot: PVRL1_HUMAN, Q15223
  • Ectodermal dysplasia, Margarita Island type (EDMI) [MIM:225060]: An autosomal recessive form of
    ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal
    structures. It is a syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse
    short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two
    thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Non-syndromic orofacial cleft 7 (OFC7) [MIM:225060]: A birth defect consisting of cleft lips with or
    without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on
    one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip
    extending into the floor of the nostril and involving the upper gum. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/27 diseases for PVRL1 (see all 27):    About MalaCards
    herpes simplex    cleft lip    zlotogora syndrome    orofacial cleft 7
    orofacial cleft    adult syndrome    cleft palate    ectodermal dysplasia
    chronic mucocutaneous candidiasis    cleft lip +/- cleft palate    birth defects    candidiasis
    syndactyly    vaginitis    microphthalmia    endotheliitis
    thyroid cancer    ulcerative colitis    acute myeloid leukemia    myeloid leukemia

    3 diseases from the University of Copenhagen DISEASES database for PVRL1:
    Cleft lip     Cleft palate     Herpes simplex

    PVRL1 for disorders           About GeneDecksing

    10/13 Novoseek inferred disease relationships for PVRL1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 79.5 47 9861033 (2), 12915538 (2), 12885915 (2), 15731277 (2) (see all 25)
    pseudorabies 72.1 13 17872513 (1), 15534229 (1), 11437670 (1), 11531408 (1) (see all 6)
    cleft palate 55 2 16674562 (1), 18356023 (1)
    herpes 53.3 11 17164781 (4), 17327376 (2), 16000587 (2), 18803666 (1) (see all 6)
    cleft lip 43.4 5 16122939 (1), 19715471 (1), 16674562 (1), 19408722 (1) (see all 5)
    carcinoma squamous cell 2.71 4 17525764 (2), 16879022 (1), 17164781 (1)
    tumors 1 11 17164781 (3), 16879022 (2), 17525764 (1), 16947118 (1) (see all 8)
    virus infection 0 3 12885915 (1), 17005657 (1), 19161552 (1)
    neurological disorders 0 2 18005714 (1), 16599187 (1)
    dysplasia 0 2 16879022 (1), 10932188 (1)

    Genetic Association Database (GAD): PVRL1
    Human Genome Epidemiology (HuGE) Navigator: PVRL1 (13 documents)

    Export disorders for PVRL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PVRL1 gene, integrated from 9 sources (see all 178):
    (articles sorted by number of sources associating them with PVRL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. (PubMed id 9616127)1, 2, 3, 9 Geraghty R.J....Spear P.G. (1998)
    2. cDNA characterization and chromosomal localization of a gene related to the poliovirus receptor gene. (PubMed id 7721102)1, 2, 3 Lopez M....Dubreuil P. (1995)
    3. Mutation analysis of the PVRL1 gene in caucasians wit h nonsyndromic cleft lip/palate. (PubMed id 19715471)1, 4, 9 SAPzen M.A....Spritz R.A. (2009)
    4. Interaction of integrin alpha(v)beta3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions. (PubMed id 16679515)1, 2, 9 Sakamoto Y....Takai Y. (2006)
    5. Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. (PubMed id 11544254)1, 2, 9 Reymond N.... Lopez M. (2001)
    6. Study of the PVRL1 gene in Italian nonsyndromic cleft lip patients with or without cleft palate. (PubMed id 16674562)1, 4, 9 Scapoli L....Carinci F. (2006)
    7. Study of the poliovirus receptor related-1 gene in Thai patients with non-syndromic cleft lip with or without cleft palate. (PubMed id 18356023)1, 4, 9 Tongkobpetch S....Shotelersuk V. (2008)
    8. [Relationship of nonsyndromic cleft lip and/or palate and poliovirus receptor-related 1 exon 3 polymorphisms in Han people of Jiangzhe area] (PubMed id 19408722)1, 4, 9 Zhao X....Zhao X.F. (2009)
    9. Mutation analysis of CLPTM 1 and PVRL 1 genes in patients with non-syndromic clefts of lip, alveolus and palate. (PubMed id 16122939)1, 4, 9 Turhani D....Ewers R. (2005)
    10. Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia. (PubMed id 10932188)1, 2, 9 Suzuki K.... Spritz R.A. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5818 HGNC: 9706 AceView: PVRL1 Ensembl:ENSG00000110400 euGenes: HUgn5818
    ECgene: PVRL1 Kegg: 5818 H-InvDB: PVRL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PVRL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PVRL1 gene:
    Search GeneIP for patents involving PVRL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PVRL1
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PVRL1 (Nectin-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for PVRL1 (Nectin-1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PVRL1   OriGene RNAi products in human, mouse, rat for PVRL1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PVRL1  
     OriGene MassSpec something-or-other for PVRL1   OriGene clones in human, mouse for PVRL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PVRL1   OriGene Purified Protein for PVRL1  
     OriGene ORF clones in mouse, rat for PVRL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PVRL1   OriGene Custom Protein Services for PVRL1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PVRL1
     QIAGEN SeqTarget long-range PCR primers for resequencing PVRL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PVRL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PVRL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PVRL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PVRL1
     GenScript Custom Purified and Recombinant Proteins Services for PVRL1 GenScript cDNA clones with any tag delivered in your preferred vector for PVRL1
     GenScript Custom Assay Services for PVRL1 GenScript Custom Superior Antibodies Services for PVRL1
     GenScript Custom overexpressing Cell Line Services for PVRL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PVRL1 promoter
     Search Chromatin IP Primers for PVRL1
     RT2 qPCR Primer Assay in human, mouse, rat PVRL1
     GNC Network for PVRL1
     SABiosciences PCR Arrays including human, mouse, rat PVRL1
     Search Tocris compounds for PVRL1
     Proteins and Antibodies for PVRL1
     Cell Lysates for PVRL1
     cDNA Clones for PVRL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PVRL1 antibodies
     PVRL1 proteins
     PVRL1 lysates
     Antibodies for PVRL1
     See all of Abcam's Antibodies, Kits and Proteins for PVRL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PVRL1
     Antibodies for PVRL1
     ELISAs for PVRL1
     CLIAs for PVRL1
     Search LifeMap BioReagents cell lines for PVRL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PVRL1
     SwitchGear 3'UTR luciferase reporter plasmids for PVRL1
     SwitchGear Promoter luciferase reporter plasmids for PVRL1
     ThermoFisher Antibodies for PVRL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PVRL1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PVRL1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PVRL1
    Customized:
     lentivirus for stable overexpression of PVRL1
     lentivirus expression plasmids for stable overexpression of PVRL1
     adenovirus for overexpression of PVRL1
     LSBio Antibodies in human, mouse, rat for PVRL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PVRL1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4