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Aliases for PVR Gene

Aliases for PVR Gene

  • Poliovirus Receptor 2 3 5
  • Nectin-Like Protein 5 3 4
  • Necl-5 3 4
  • PVS 3 4
  • Nectin-Like 5 2
  • CD155 Antigen 4
  • CD155 3
  • NECL5 3
  • TAGE4 3
  • HVED 3

External Ids for PVR Gene

Previous HGNC Symbols for PVR Gene

  • PVS

Previous GeneCards Identifiers for PVR Gene

  • GC19P045791
  • GC19P045538
  • GC19P049823
  • GC19P049839
  • GC19P045147
  • GC19P041579

Summaries for PVR Gene

Entrez Gene Summary for PVR Gene

  • The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for PVR Gene

PVR (Poliovirus Receptor) is a Protein Coding gene. Diseases associated with PVR include Poliomyelitis and Paralytic Poliomyelitis. Among its related pathways are Cell junction organization and Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include receptor activity and virus receptor activity. An important paralog of this gene is NECTIN3.

UniProtKB/Swiss-Prot for PVR Gene

  • Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.

  • (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport (PubMed:2538245). Acts as a receptor for pseudorabies virus (PubMed:9616127). Is prevented to reach cell surface upon infection by human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells (PubMed:15640804).

Gene Wiki entry for PVR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PVR Gene

Genomics for PVR Gene

Regulatory Elements for PVR Gene

Enhancers for PVR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PVR on UCSC Golden Path with GeneCards custom track

Promoters for PVR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PVR on UCSC Golden Path with GeneCards custom track

Genomic Location for PVR Gene

Chromosome:
19
Start:
44,643,798 bp from pter
End:
44,666,161 bp from pter
Size:
22,364 bases
Orientation:
Plus strand

Genomic View for PVR Gene

Genes around PVR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PVR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PVR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PVR Gene

Proteins for PVR Gene

  • Protein details for PVR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15151-PVR_HUMAN
    Recommended name:
    Poliovirus receptor
    Protein Accession:
    P15151
    Secondary Accessions:
    • B4DTS9
    • P15152
    • Q15267
    • Q15268
    • Q96BJ1

    Protein attributes for PVR Gene

    Size:
    417 amino acids
    Molecular mass:
    45303 Da
    Quaternary structure:
    • Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Binds with high affinity to TIGIT.
    • (Microbial infection) Interacts with poliovirus capsid proteins.
    • (Microbial infection) Interacts with human cytomegalovirus /HHV-5 UL141 protein.
    • (Microbial infection) Interacts with pseudorabies virus gD protein.
    Miscellaneous:
    • The V-type domain is necessary and sufficient for virus binding and uptake.

    Three dimensional structures from OCA and Proteopedia for PVR Gene

    Alternative splice isoforms for PVR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PVR Gene

Proteomics data for PVR Gene at MOPED

Post-translational modifications for PVR Gene

  • N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4.
  • Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.
  • Glycosylation at Asn 105, Asn 120, Asn 188, Asn 218, Asn 237, Asn 278, Asn 307, and Asn 313
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PVR (PVR)

No data available for DME Specific Peptides for PVR Gene

Domains & Families for PVR Gene

Suggested Antigen Peptide Sequences for PVR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15151

UniProtKB/Swiss-Prot:

PVR_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the nectin family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with PVR: view

Function for PVR Gene

Molecular function for PVR Gene

GENATLAS Biochemistry:
poliovirus sensitivity,receptor
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=72 nM for VTN;
UniProtKB/Swiss-Prot Function:
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport (PubMed:2538245). Acts as a receptor for pseudorabies virus (PubMed:9616127). Is prevented to reach cell surface upon infection by human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells (PubMed:15640804).
UniProtKB/Swiss-Prot Induction:
Transcriptionally regulated by SHH.

Gene Ontology (GO) - Molecular Function for PVR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 2538245
genes like me logo Genes that share ontologies with PVR: view
genes like me logo Genes that share phenotypes with PVR: view

Human Phenotype Ontology for PVR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PVR Gene

Localization for PVR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PVR Gene

Isoform Alpha: Cell membrane; Single-pass type I membrane protein.
Isoform Delta: Cell membrane; Single-pass type I membrane protein.
Isoform Beta: Secreted.
Isoform Gamma: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PVR Gene COMPARTMENTS Subcellular localization image for PVR gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 3
endoplasmic reticulum 2
endosome 2
lysosome 2
vacuole 2
cytoskeleton 1
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PVR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 2170108
GO:0005887 integral component of plasma membrane IBA --
GO:0005913 cell-cell adherens junction IBA --
genes like me logo Genes that share ontologies with PVR: view

Pathways & Interactions for PVR Gene

genes like me logo Genes that share pathways with PVR: view

Gene Ontology (GO) - Biological Process for PVR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP 12913096
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with PVR: view

No data available for SIGNOR curated interactions for PVR Gene

Drugs & Compounds for PVR Gene

(35) Drugs for PVR Gene - From: DrugBank and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 105
Dalteparin Approved Pharma 283
Dexamethasone Approved, Investigational Pharma Agonist 1950
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1697
Heparin Approved, Investigational Pharma Antagonist 761,246
genes like me logo Genes that share compounds with PVR: view

Transcripts for PVR Gene

Unigene Clusters for PVR Gene

Poliovirus receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PVR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5: - - -

Relevant External Links for PVR Gene

GeneLoc Exon Structure for
PVR
ECgene alternative splicing isoforms for
PVR

Expression for PVR Gene

mRNA expression in normal human tissues for PVR Gene

Protein differential expression in normal tissues from HIPED for PVR Gene

This gene is overexpressed in Amniocyte (15.7), Cerebrospinal fluid (12.6), Serum (8.5), and Urine (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PVR Gene



SOURCE GeneReport for Unigene cluster for PVR Gene Hs.171844

genes like me logo Genes that share expression patterns with PVR: view

Protein tissue co-expression partners for PVR Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PVR Gene

Orthologs for PVR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PVR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PVR 35
  • 67.47 (n)
  • 56.15 (a)
dog
(Canis familiaris)
Mammalia PVR 35
  • 72.07 (n)
  • 61.08 (a)
PVR 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PVR 35
  • 98.24 (n)
  • 97.6 (a)
PVR 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PVR 36
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pvr 36
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pvrl2l 36
  • 24 (a)
ManyToMany
si:ch211-141e20.2 36
  • 22 (a)
ManyToMany
si:ch211-214p13.3 36
  • 17 (a)
ManyToMany
si:ch211-222f23.6 36
  • 22 (a)
ManyToMany
si:ch73-22o12.1 36
  • 27 (a)
ManyToMany
si:dkey-281i8.1 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
OneToMany
Species with no ortholog for PVR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PVR Gene

ENSEMBL:
Gene Tree for PVR (if available)
TreeFam:
Gene Tree for PVR (if available)

Paralogs for PVR Gene

Paralogs for PVR Gene

(1) SIMAP similar genes for PVR Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PVR: view

Variants for PVR Gene

Sequence variations from dbSNP and Humsavar for PVR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1058402 - 44,647,342(+) CTTGG(A/G)CGCGG reference, missense
rs203710 - 44,658,770(+) GGCAT(A/G)TCCCG intron-variant, reference, missense
rs35365841 - 44,657,802(+) AGGGC(A/G)CCCAG intron-variant, reference, missense
rs12976059 -- 44,645,119(+) atata(A/T)tatat intron-variant
rs12976066 -- 44,645,169(+) ttata(A/T)tatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PVR Gene

Variant ID Type Subtype PubMed ID
nsv483005 CNV Loss 15286789
nsv912116 CNV Loss 21882294
nsv9736 CNV Loss 18304495

Variation tolerance for PVR Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PVR Gene

Human Gene Mutation Database (HGMD)
PVR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PVR Gene

Disorders for PVR Gene

MalaCards: The human disease database

(17) MalaCards diseases for PVR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
poliomyelitis
  • infantile paralysis
paralytic poliomyelitis
  • poliomyelitis, paralytic
heart conduction disease
  • heart rhythm disease
pericardium disease
basilar artery insufficiency
  • basilar artery syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PVR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PVR

Genetic Association Database (GAD)
PVR
Human Genome Epidemiology (HuGE) Navigator
PVR
Tumor Gene Database (TGDB):
PVR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PVR
genes like me logo Genes that share disorders with PVR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PVR Gene

Publications for PVR Gene

  1. The poliovirus receptor protein is produced both as membrane-bound and secreted forms. (PMID: 2170108) Koike S. … Nomoto A. (EMBO J. 1990) 2 3 4 67
  2. CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains. (PMID: 19056733) Meyer D. … Bernhardt G. (J. Biol. Chem. 2009) 3 23
  3. Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells. (PMID: 19801517) Carlsten M. … Malmberg K.J. (J. Immunol. 2009) 3 23
  4. Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. (PMID: 19011098) Zhang P. … Rossmann M.G. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  5. Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). (PMID: 15536144) Pende D. … Moretta L. (Blood 2005) 3 23

Products for PVR Gene

Sources for PVR Gene

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