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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PVR Gene

protein-coding   GIFtS: 66
GCID: GC19P045147

poliovirus receptor


(Previous symbol: PVS)
 Explore 34 diseases affiliated with
PVR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PVR    

Aliases
for PVR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Poliovirus Receptor1 2     Nectin-Like Protein 52 3
PVS1 2 3 5     Tage41
CD1551 2     TAGE42
HVED1 2     Nectin-Like 52
NECL51 2     NECL-53
Necl-51 2     CD155 Antigen3

External Ids:    HGNC: 97051   Entrez Gene: 58172   Ensembl: ENSG000000730087   OMIM: 1738505   UniProtKB: P151513   

Export aliases for PVR gene to outside databases

Previous GC identifers: GC19P045791 GC19P045538 GC19P049823 GC19P049839 GC19P041579


Summaries
for PVR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PVR:
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The
external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular
domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves
as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: PVR_HUMAN, P15151
Function: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors:
CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature
immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and
IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and
PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may
trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating
tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in
axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network
through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde
transport

Gene Wiki entry for PVR (CD155)


Genomic Views
for PVR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PVR gene promoter:
         Pax-5   p53   Brachyury   AP-4   RelA   NF-kappaB   HEN1   GCNF-1   NF-kappaB1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PVR promoter sequence
   Search SABiosciences Chromatin IP Primers for PVR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PVR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

PVR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PVR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045147:  view genomic region     (about GC identifiers)

Start:
 45,147,098 bp from pter      End:
 45,169,429 bp from pter
Size:
 22,332 bases      Orientation:
 plus strand

Proteins
for PVR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PVR_HUMAN, P15151 (See protein sequence)
Recommended Name: Poliovirus receptor precursor  
Size: 417 amino acids; 45303 Da
Subunit: Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and CD96.
The cytoplasmic domain interacts with DYNLT1. Interacts with HHV-5 UL141. Interacts with poliovirus capsid composed of
VP1, VP2 and VP3, mainly through VP3. Binds with high affinity to TIGIT
Subcellular location: Isoform Alpha: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform Delta: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform Beta: Secreted
Subcellular location: Isoform Gamma: Secreted
Miscellaneous: The V-type domain is necessary and sufficient for virus binding and uptake
6/8 PDB 3D structures from and Proteopedia for PVR (see all 8):
1DGI (3D)        1NN8 (3D)        3EPC (3D)        3EPD (3D)        3EPF (3D)        3UDW (3D)    
Secondary accessions: B4DTS9 P15152 Q15267 Q15268 Q96BJ1
Alternative splicing: 4 isoforms:  P15151-1   P15151-2   P15151-3   P15151-4   (Glycosylated on Asn-352)

Explore the universe of human proteins at neXtProt for PVR: NX_P15151

Post-translational modifications:

  • N-glycosylated. N-glycan at Asn-120: Hex5HexNAc41
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15151

    • PVR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129240.1  NP_001129241.1  NP_001129242.1  NP_006496.3  

    ENSEMBL proteins: 
     ENSP00000402060   ENSP00000385344   ENSP00000187830   ENSP00000383907   ENSP00000466447  
     ENSP00000467982   ENSP00000340870  
    Reactome Protein details: P15151
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for PVR (CD155/PVR)
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    OriGene Protein Over-expression Lysate (see all 3): PVR
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    Novus Biologicals PVR Proteins
    Novus Biologicals PVR Lysates
    Sino Biological Recombinant Protein for PVR
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PVR

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS2170108
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS2170108
    GO:0005886plasma membrane TAS--


    PVR for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PVR

    Protein Domains /
    Families
    for PVR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PVR for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013162 CD80_C2-set
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P15151

    ProtoNet protein and cluster: P15151

    2 Blocks protein families:
    IPB003596 Immunoglobulin V-type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: PVR_HUMAN, P15151
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for PVR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PVR_HUMAN, P15151
    Function: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors:
    CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature
    immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and
    IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and
    PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may
    trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating
    tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in
    axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network
    through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde
    transport
    Biophysicochemical properties: Kinetic parameters: KM=72 nM for VTN;
    Induction: Transcriptionally regulated by SHH

         Genatlas biochemistry entry for PVR:
    poliovirus sensitivity,receptor

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PVR:
    hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: PVR 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PVR (see all 4)
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PVR 

    Cell Line
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    Search LifeMap BioReagents cell lines for PVR

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS2538245
    GO:0005515protein binding IPI19011627
    GO:0050839cell adhesion molecule binding IPI12913096


    PVR for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for PVR: Pvrtm1Hfuk Pvrtm1Gbn
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pvr):
     homeostasis/metabolism  immune system  tumorigenesis 

    PVR for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PVR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Adherens junctions interactions0.51
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3Nectin/Necl trans heterodimerization
    		Nectin/Necl trans heterodimerization1.00
    4Nectin adhesion pathway
    		Nectin adhesion pathway1.00
    5Cell adhesion molecules (CAMs)
    		Cell adhesion molecules (CAMs)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for PVR 
        Nectin adhesion pathway

    5/8        Reactome Pathways for PVR (see all 8)
        Adherens junctions interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Nectin/Necl trans heterodimerization
    Cell junction organization
    Adaptive Immune System


    1         Kegg Pathway  (Kegg details for PVR):
        Cell adhesion molecules (CAMs)


    PVR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PVR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/20 Interacting proteins for PVR (P151512, 3 ENSP000004020604) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH1P128302, 3, ENSP000002617694MINT-5224658 I2D: score=1 STRING: ENSP00000261769
    TJP1Q071572, 3, ENSP000002815374MINT-5224586 I2D: score=1 STRING: ENSP00000281537
    AP1M2Q9Y6Q53, ENSP000002502444I2D: score=2 STRING: ENSP00000250244
    CD226Q157623, ENSP000002802004I2D: score=2 STRING: ENSP00000280200
    PVRL3Q9NQS33, ENSP000004180704I2D: score=2 STRING: ENSP00000418070
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP12913096
    GO:0007155cell adhesion ----
    GO:0016337cell-cell adhesion IEA--
    GO:0016477cell migration IEA--
    GO:0019048virus-host interaction IEA--


    PVR for ontologies           About GeneDecksing



    Drugs & Compounds
    for PVR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PVR

    2 DrugBank Compounds for PVR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MYRISTIC ACID-- --target--10592235
    Sphingosine-- 123-78-4target--10592235

    Search CenterWatch for drugs/clinical trials and news about PVR 

    Transcripts
    for PVR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PVR gene (4 alternative transcripts): 
    NM_001135768.1  NM_001135769.1  NM_001135770.1  NM_006505.3  

    Unigene Cluster for PVR:

    Poliovirus receptor
    Hs.171844  [show with all ESTs]
    Unigene Representative Sequence: NM_006505
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425690(uc010ejs.3) ENST00000403059 ENST00000187830 ENST00000406449
    ENST00000587785 ENST00000592047 ENST00000344956(uc002ozm.3 uc010xxb.2 uc010xxc.2 uc002ozn.3)


    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PVR:
    hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: PVR 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: PVR
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    Clone
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    Additional cDNA sequence: 

    AK025949.1 AK094177.1 AK098812.1 AK290946.1 AK300349.1 BC015542.1 M24406.1 M24407.1 

    10 DOTS entries:

    DT.416566  DT.100783927  DT.75187267  DT.100783929  DT.91760736  DT.108862  DT.121481650  DT.40263174 
    DT.91760729  DT.95068821 

    24/329 AceView cDNA sequences (see all 329):

    BQ674835 CA487502 BX110265 AW169525 CD622813 AK025949 AI374885 CF265015 
    CD358085 AA476686 AL390165 AA812985 BU146353 T17080 BE301927 BM723085 
    CA429918 AI193505 AI123649 BF002687 AI613121 AA148701 F04202 BF724184 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PVR    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                    -     -                                         -         
    SP2:                    -                                               -         
    SP3:                    -                                                         
    SP4:                                                                              
    SP5:                                                        -     -     -         


    ECgene alternative splicing isoforms for PVR

    Expression
    for PVR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PVR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACCACCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PVR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium

    See PVR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PVR

    SOURCE GeneReport for Unigene cluster: Hs.171844
        SABiosciences Expression via Pathway-Focused PCR Arrays including PVR: 
              Necrosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PVR
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PVR

    Orthologs
    for PVR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PVR gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 29(a)
    		 1 → many
    		 GL343816.1(102408-141702)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch73-22o12.16
    pvrl2l6
    (see all 6)    		 poliovirus receptor-related 2 like
    (see all 6)    		 25(a)
    24(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 16(12167019-12247451)
    19(7062874-7397291)


    ENSEMBL Gene Tree for PVR (if available)
    TreeFam Gene Tree for PVR (if available) 

    Paralogs
    for PVR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PVR gene
    CADM42  CRTAM2  CADM12  PVRL42  PVRL32  CADM32  PVRL22  CADM22  
    PVRL12  
    1 SIMAP similar gene for PVR using alignment to 4 protein entries:     PVR_HUMAN (see all proteins):
    PVRL2

    PVR for paralogs           About GeneDecksing



    Genomic Variants
    for PVR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/531 NCBI SNPs in PVR are shown (see all 531)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2037191,2
    		C,F,A,H,--41577379(+) TTTCCA/GTTTAG 4 -- us2k111Minor allele frequency- G:0.06NS EA NA WA 1394
    rs614303601,2
    		C,--41577454(+) AGATCC/TAAGTT 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs621192821,2
    		--41577866(+) AGGGAC/TCAGAG 4 -- us2k12Minor allele frequency- T:0.13NA 122
    rs1114339551,2
    		F--41577973(+) TCTCTC/TTGTCA 4 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs735659291,2
    		C,--41578244(+) TGTTTC/TCCTCC 4 -- us2k13Minor allele frequency- T:0.11WA NA 240
    rs1150171511,2
    		C,F,--41578280(+) CAGAGA/GTTTTT 4 -- us2k11Minor allele frequency- G:0.02WA 118
    rs713627001,2
    		C,F--41579173(+) AGGATG/CTGTCC 4 -- us2k12Minor allele frequency- C:0.50NA 4
    rs72488461,2
    		C,A,--41580755(+) tatatA/Tatata 4 -- int10--------
    rs562612581,2
    		F,--41581934(+) TGCAGC/TGTTTC 4 -- int11Minor allele frequency- T:0.13NA 120
    rs1164436531,2
    		C,F,--41582048(+) ACCTAC/TGACAC 4 -- int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for PVR (45147098 - 45169429 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PVR
         1 CNV: 0221
    Human Gene Mutation Database (HGMD): PVR

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PVR
    DNA2.0 Custom Variant and Variant Library Synthesis for PVR

    Disorders / Diseases
    for PVR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PVR for disorders           About GeneDecksing

    OMIM gene information: 173850    OMIM disorders: --

    20/34 diseases for PVR (see all 34):    About MalaCards
    pigmented villonodular synovitis    villonodular synovitis    paralytic poliomyelitis    epidermodysplasia verruciformis
    pulmonary valve stenosis    poliomyelitis    synovitis    malignant glioma
    myotonic dystrophy    motor neuron disease    herpes simplex    liver cirrhosis
    balanitis    hepatitis c    lymphoblastic leukemia    stomatitis
    vaccinia    meningitis    lung adenocarcinoma    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for PVR:
    Poliomyelitis

    9 Novoseek disease relationships for PVR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polio 79 11 9188553 (1), 10777530 (1), 11597452 (1), 9203668 (1) (see all 11)
    pseudorabies 50.7 4 11255021 (1), 11454801 (1)
    paralysis 48.8 1 7476091 (1)
    malignant glioma 18.1 2 15279713 (1), 10841575 (1)
    tumors 15.3 19 15279713 (3), 15607800 (2), 15471548 (2), 19029379 (1) (see all 9)
    metastasis 0 2 14871893 (1), 17404872 (1)
    adenoma 0 3 11454801 (2), 11255021 (1)
    cancer 0 3 11454801 (1), 15471548 (1)
    immunodeficiency 0 1 11602758 (1)

    Genetic Association Database (GAD): PVR
    Human Genome Epidemiology (HuGE) Navigator: PVR (9 documents)
    Tumor Gene Database (TGDB): PVR

    Export disorders for PVR gene to outside databases

    Publications
    for PVR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PVR gene, integrated from 9 sources (see all 149):
    (articles sorted by number of sources associating them with PVR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The poliovirus receptor protein is produced both as membrane-bound and secreted forms. (PubMed id 2170108)1, 2, 3 Koike S.... Nomoto A. (1990)
    2. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). (PubMed id 15039383)1, 2, 9 Tahara-Hanaoka S.... Shibuya A. (2004)
    3. PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. (PubMed id 15607800)1, 2, 9 Pende D.... Moretta A. (2005)
    4. CD155/PVR plays a key role in cell motility during tumor cell invasion and migration. (PubMed id 15471548)1, 2, 9 Sloan K.E.... Jay D.G. (2004)
    5. CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). (PubMed id 15034010)1, 2, 9 Fuchs A.... Colonna M. (2004)
    6. The poliovirus receptor CD155 mediates cell-to-matrix contacts by specifically binding to vitronectin. (PubMed id 11437656)1, 2, 9 Lange R.... Bernhardt G. (2001)
    7. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. (PubMed id 15640804)1, 2, 9 Tomasec P.... Wilkinson G.W. (2005)
    8. Interaction of the poliovirus receptor with poliovirus. (PubMed id 10618374)1, 2, 9 He Y.... Rossmann M.G. (2000)
    9. N glycosylation of the virus binding domain is not essential for function of the human poliovirus receptor. (PubMed id 1331527)1, 2, 9 Zibert A. and Wimmer E. (1992)
    10. Functional domains of the poliovirus receptor. (PubMed id 1851992)1, 2, 9 Koike S.... Nomoto A. (1991)

    External Searches for PVR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PVR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5817 HGNC: 9705 AceView: PVRandCEAL1andLOC440536 Ensembl:ENSG00000073008 euGenes: HUgn5817
    ECgene: PVR Kegg: 5817 H-InvDB: PVR

    Other Databases showing PVR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PVR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PVR Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt075.shtml

    Intellectual Property
    for PVR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PVR gene:
    Search GeneIP for patents involving PVR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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