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PVR Gene

protein-coding   GIFtS: 68
GCID: GC19P045147

Poliovirus Receptor


(Previous symbol: PVS)
  See PVR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Poliovirus Receptor1 2     NECL52
PVS1 2 3 5     Necl-52
Nectin-Like 51 2     TAGE42
Nectin-Like Protein 52 3     NECL-53
CD1552     CD155 Antigen3
HVED2     

External Ids:    HGNC: 97051   Entrez Gene: 58172   Ensembl: ENSG000000730087   OMIM: 1738505   UniProtKB: P151513   

Export aliases for PVR gene to outside databases

Previous GC identifers: GC19P045791 GC19P045538 GC19P049823 GC19P049839 GC19P041579


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PVR Gene:
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The
external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its
intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate
lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2008)

GeneCards Summary for PVR Gene:
PVR (poliovirus receptor) is a protein-coding gene. Diseases associated with PVR include poliomyelitis, and paralytic poliomyelitis. GO annotations related to this gene include receptor activity and cell adhesion molecule binding. An important paralog of this gene is PVRL2.

UniProtKB/Swiss-Prot: PVR_HUMAN, P15151
Function: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell
receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation
of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of
lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell
modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing
a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion.
Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to
target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic
vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the
virus-containing vesicle to the axonal retrograde transport

Gene Wiki entry for PVR (CD155) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PVR gene promoter:
         Pax-5   p53   Brachyury   AP-4   RelA   NF-kappaB   HEN1   GCNF-1   NF-kappaB1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPVR promoter sequence
   Search Chromatin IP Primers for PVR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PVR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

PVR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PVR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045147:  view genomic region     (about GC identifiers)

Start:
45,147,098 bp from pter      End:
45,169,429 bp from pter
Size:
22,332 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PVR_HUMAN, P15151 (See protein sequence)
Recommended Name: Poliovirus receptor precursor  
Size: 417 amino acids; 45303 Da
Subunit: Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and
CD96. The cytoplasmic domain interacts with DYNLT1. Interacts with HHV-5 UL141. Interacts with poliovirus capsid
composed of VP1, VP2 and VP3, mainly through VP3. Binds with high affinity to TIGIT
Miscellaneous: The V-type domain is necessary and sufficient for virus binding and uptake
Selected PDB 3D structures from and Proteopedia for PVR (see all 8):
1DGI (3D)        1NN8 (3D)        3EPC (3D)        3EPD (3D)        3EPF (3D)        3UDW (3D)    
Secondary accessions: B4DTS9 P15152 Q15267 Q15268 Q96BJ1
Alternative splicing: 4 isoforms:  P15151-1   P15151-2   P15151-3   P15151-4   (Glycosylated on Asn-352)

Explore the universe of human proteins at neXtProt for PVR: NX_P15151

Explore proteomics data for PVR at MOPED

Post-translational modifications: 

  • N-glycosylated. N-glycan at Asn-120: Hex5HexNAc41
  • Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is
    required for Phosphorylation1
  • Glycosylation2 at Asn105, Asn120, Asn188, Asn218, Asn237, Asn278, Asn307, Asn313
  • Modification sites at PhosphoSitePlus

  • See PVR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129240.1  NP_001129241.1  NP_001129242.1  NP_006496.3  

    ENSEMBL proteins: 
     ENSP00000402060   ENSP00000340870   ENSP00000385344   ENSP00000187830   ENSP00000383907  
     ENSP00000466447  
    Reactome Protein details: P15151

    PVR Human Recombinant Protein Products:

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    Novus Biologicals PVR Proteins
    Novus Biologicals PVR Lysates
    Sino Biological Recombinant Protein for PVR
    Sino Biological Cell Lysate for PVR
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    Cloud-Clone Corp. Proteins for PVR

     
    Search eBioscience for Proteins for PVR 

    PVR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for PVR
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    ThermoFisher Antibody for PVR
    LSBio Antibodies in human, mouse, rat for PVR

    PVR Assay Products:

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    Cloud-Clone Corp. ELISAs for PVR
    Cloud-Clone Corp. CLIAs for PVR
    Search eBioscience for ELISAs for PVR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR013162 CD80_C2-set
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P15151

    ProtoNet protein and cluster: P15151

    2 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: PVR_HUMAN, P15151
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the nectin family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with PVR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PVR_HUMAN, P15151
    Function: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell
    receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation
    of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of
    lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell
    modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing
    a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion.
    Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to
    target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic
    vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the
    virus-containing vesicle to the axonal retrograde transport
    Biophysicochemical properties: Kinetic parameters: KM=72 nM for VTN;
    Induction: Transcriptionally regulated by SHH

         Genatlas biochemistry entry for PVR:
    poliovirus sensitivity,receptor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0004872receptor activity TAS2538245
    GO:0005515protein binding IPI19011627
    GO:0050839cell adhesion molecule binding IPI12913096
         
    Find genes that share ontologies with PVR           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pvr):
     hematopoietic system  homeostasis/metabolism  immune system  tumorigenesis 

    Find genes that share phenotypes with PVR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PVR: Pvrtm1Hfuk Pvrtm1Gbn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PVR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PVR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PVR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PVR

    miRNA
    Products:
        
    miRTarBase miRNAs that target PVR:
    hsa-let-7b-5p (MIRT032490), hsa-mir-16-5p (MIRT031973), hsa-mir-615-3p (MIRT040310)

    Block miRNA regulation of human, mouse, rat PVR using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PVR:
    hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidPVR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PVR
    Predesigned siRNA for gene silencing in human, mouse, rat PVR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PVR

    Clone
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    OriGene ORF clones in mouse, rat for PVR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PVR (NM_006505)
    Sino Biological Human cDNA Clone for PVR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PVR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PVR

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PVR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PVR_HUMAN, P15151: Isoform Alpha: Cell membrane; Single-pass type I membrane protein
    PVR_HUMAN, P15151: Isoform Delta: Cell membrane; Single-pass type I membrane protein
    PVR_HUMAN, P15151: Isoform Beta: Secreted
    PVR_HUMAN, P15151: Isoform Gamma: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus4
    cytoskeleton1
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS2170108
    GO:0005634nucleus ----
    GO:0005737cytoplasm TAS2170108
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA16831868

    Find genes that share ontologies with PVR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PVR About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Adherens junctions interactions0.49
    Cell-cell junction organization0.70
    Nectin/Necl trans heterodimerization0.00
    Cell-Cell communication0.64
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Nectin adhesion pathway
    Nectin adhesion pathway
    4Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    5Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with PVR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PVR
        Nectin adhesion pathway


    2 Reactome Pathways for PVR
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Nectin/Necl trans heterodimerization


    1 Kegg Pathway  (Kegg details for PVR):
        Cell adhesion molecules (CAMs)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PVR: 
              Necrosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PVR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PVR (P151512, 3 ENSP000004020604) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH1P128302, 3, ENSP000002617694MINT-5224658 I2D: score=1 STRING: ENSP00000261769
    TJP1Q071572, 3, ENSP000002815374MINT-5224586 I2D: score=1 STRING: ENSP00000281537
    AP1M2Q9Y6Q53, ENSP000002502444I2D: score=2 STRING: ENSP00000250244
    CD226Q157623, ENSP000002802004I2D: score=2 STRING: ENSP00000280200
    CD96P402003, ENSP000002832854I2D: score=1 STRING: ENSP00000283285
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP12913096
    GO:0007155cell adhesion ----
    GO:0009615response to virus ----
    GO:0016032viral process IEA--
    GO:0016337cell-cell adhesion IEA--

    Find genes that share ontologies with PVR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PVR

    2 DrugBank Compounds for PVR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MYRISTIC ACID-- --target--10592235
    Sphingosine-- 123-78-4target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PVR gene (4 alternative transcripts): 
    NM_001135768.1  NM_001135769.1  NM_001135770.2  NM_006505.3  

    Unigene Cluster for PVR:

    Poliovirus receptor
    Hs.171844  [show with all ESTs]
    Unigene Representative Sequence: NM_006505
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425690(uc010ejs.3) ENST00000344956(uc002ozm.3 uc010xxb.2 uc010xxc.2 uc002ozn.3)
    ENST00000403059 ENST00000187830 ENST00000406449 ENST00000587785
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate PVR:
    hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidPVR 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): PVR (NM_006505)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PVR
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PVR
      QuantiTect SYBR Green Assays in human, mouse, rat PVR
      QuantiFast Probe-based Assays in human, mouse, rat PVR

    Additional mRNA sequence: 

    AK025949.1 AK094177.1 AK098812.1 AK290946.1 AK300349.1 BC015542.1 M24406.1 M24407.1 

    10 DOTS entries:

    DT.416566  DT.100783927  DT.75187267  DT.100783929  DT.91760736  DT.108862  DT.121481650  DT.40263174 
    DT.91760729  DT.95068821 

    Selected AceView cDNA sequences (see all 329):

    CO247073 BI820071 BQ943688 AV649366 AA470006 AI123649 M24407 AI613121 
    CF265015 CD622813 BE301927 BM990082 BQ233208 CB147568 BC015542 BX110265 
    CA487502 AI193505 AW169525 BF724184 AA650273 F04991 CO396450 AA812985 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PVR    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                    -     -                                         -         
    SP2:                    -                                               -         
    SP3:                    -                                                         
    SP4:                                                                              
    SP5:                                                        -     -     -         


    ECgene alternative splicing isoforms for PVR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PVR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCACCCAG
    PVR Expression
    About this image


    PVR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    PVR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PVR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171844
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PVR: 
              Necrosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PVR
    OriGene qSTAR qPCR primer pairs in human, mouse for PVR
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PVR
    QuantiTect SYBR Green Assays in human, mouse, rat PVR
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PVR gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pvr5 poliovirus receptor   --   7 (9.95 cM) 19903578 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    1 → many
    GL343816.1(31311-141702)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-22o12.16
    pvrl2l6
    (see all 6)
    poliovirus receptor-related 2 like
    (see all 6)
    27(a)
    24(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    16(12167019-12247451) ENSDARG00000062831
    19(7062874-7397291) ENSDARG00000063390


    ENSEMBL Gene Tree for PVR (if available)
    TreeFam Gene Tree for PVR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PVR gene
    PVRL22  PVRL12  PVRL42  PVRL32  
    1 SIMAP similar gene for PVR using alignment to 3 protein entries:     PVR_HUMAN (see all proteins):
    PVRL2

    Find genes that share paralogs with PVR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PVR (see all 674)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341582341,2
    C--41579763(+) TCCCG-/ACTCCG 4 -- int10--------
    rs113602991,2
    C--41580296(+) CTCCA-/TTCACC 4 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs2001934911,2
    C--41580680(+) TATAA-/TA    
       TATAT
    TATAT
    4 -- int10--------
    rs3753534281,2
    C--41581002(+) TTTGT-/TATA  
            
    ATATA
    4 -- int10--------
    rs667763941,2
    C--41589437(+) CGTAC-/GCCCAG 4 -- int10--------
    rs339192811,2
    C--41595767(+) TGTGC-/TCCCAG 3 -- int10--------
    rs58282111,2
    C--45147518(+) CTCCCA/-GCTCC 4 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs58282121,2
    C--45147577(+) CCGCC-/GCGGCG 4 -- int11Minor allele frequency- G:0.00NA 2
    rs113627241,2
    C--45148020(+) TTTTT-/TGAGAC 4 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs611456561,2
    C--45148370(+) TTATA-/TA    
       TTATA
    GTAAT
    4 -- int11Minor allele frequency- TATTATA:0.00NA 2

    HapMap Linkage Disequilibrium report for PVR (45147098 - 45169429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PVR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912116CNV Loss21882294
    nsv9736CNV Loss18304495
    nsv483005CNV Loss15286789

    Human Gene Mutation Database (HGMD): PVR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PVR
    DNA2.0 Custom Variant and Variant Library Synthesis for PVR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173850    OMIM disorders: --

    3 diseases for PVR:    
    About MalaCards
    poliomyelitis    paralytic poliomyelitis    malignant glioma

    1 disease from the University of Copenhagen DISEASES database for PVR:
    Poliomyelitis

    Find genes that share disorders with PVR           About GenesLikeMe

    9 Novoseek inferred disease relationships for PVR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polio 79 11 9188553 (1), 10777530 (1), 11597452 (1), 9203668 (1) (see all 11)
    pseudorabies 50.7 4 11255021 (1), 11454801 (1)
    paralysis 48.8 1 7476091 (1)
    malignant glioma 18.1 2 15279713 (1), 10841575 (1)
    tumors 15.3 19 15279713 (3), 15607800 (2), 15471548 (2), 19029379 (1) (see all 9)
    metastasis 0 2 14871893 (1), 17404872 (1)
    adenoma 0 3 11454801 (2), 11255021 (1)
    cancer 0 3 11454801 (1), 15471548 (1)
    immunodeficiency 0 1 11602758 (1)

    Genetic Association Database (GAD): PVR
    Human Genome Epidemiology (HuGE) Navigator: PVR (9 documents)
    Tumor Gene Database (TGDB): PVR

    Export disorders for PVR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PVR gene, integrated from 10 sources (see all 159):
    (articles sorted by number of sources associating them with PVR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The poliovirus receptor protein is produced both as membrane-bound and secreted forms. (PubMed id 2170108)1, 2, 3 Koike S.... Nomoto A. (EMBO J. 1990)
    2. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). (PubMed id 15039383)1, 2, 9 Tahara-Hanaoka S.... Shibuya A. (Int. Immunol. 2004)
    3. PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. (PubMed id 15607800)1, 2, 9 Pende D.... Moretta A. (Mol. Immunol. 2005)
    4. CD155/PVR plays a key role in cell motility during tumor cell invasion and migration. (PubMed id 15471548)1, 2, 9 Sloan K.E.... Jay D.G. (BMC Cancer 2004)
    5. CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). (PubMed id 15034010)1, 2, 9 Fuchs A.... Colonna M. (J. Immunol. 2004)
    6. The poliovirus receptor CD155 mediates cell-to-matrix contacts by specifically binding to vitronectin. (PubMed id 11437656)1, 2, 9 Lange R.... Bernhardt G. (Virology 2001)
    7. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. (PubMed id 15640804)1, 2, 9 Tomasec P.... Wilkinson G.W. (Nat. Immunol. 2005)
    8. Interaction of the poliovirus receptor with poliovirus. (PubMed id 10618374)1, 2, 9 He Y.... Rossmann M.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    9. N glycosylation of the virus binding domain is not essential for function of the human poliovirus receptor. (PubMed id 1331527)1, 2, 9 Zibert A. and Wimmer E. (J. Virol. 1992)
    10. Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts. (PubMed id 15194502)1, 2, 9 Oda T.... Nomoto A. (Biochem. Biophys. Res. Commun. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5817 HGNC: 9705 AceView: PVRandCEAL1andLOC440536 Ensembl:ENSG00000073008 euGenes: HUgn5817
    ECgene: PVR Kegg: 5817 H-InvDB: PVR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PVR Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/075

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PVR gene:
    Search GeneIP for patents involving PVR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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