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PVALB Gene

protein-coding   GIFtS: 59
GCID: GC22M037196

Parvalbumin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
parvalbumin1 2
D22S7492
Parvalbumin Alpha2

External Ids:    HGNC: 97041   Entrez Gene: 58162   Ensembl: ENSG000001003627   OMIM: 1688905   UniProtKB: P204723   
ORGUL members:         

Export aliases for PVALB gene to outside databases

Previous GC identifers: GC22M033811 GC22M035439 GC22M035521 GC22M020159


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PVALB Gene:
The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and
functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle
relaxation. (provided by RefSeq, Jul 2008)

GeneCards Summary for PVALB Gene:
PVALB (parvalbumin) is a protein-coding gene. Diseases associated with PVALB include breast fibrosarcoma, and subcortical band heterotopia. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is OCM2.

UniProtKB/Swiss-Prot: PRVA_HUMAN, P20472
Function: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium
ions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NT_187631.1  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PVALB gene promoter:
         Pax-5   AML1a   Lmo2   XBP-1   IRF-1   AP-4   Nkx2-5   E47   MZF-1   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPVALB promoter sequence
   Search Chromatin IP Primers for PVALB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PVALB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

PVALB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PVALB gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037196:  view genomic region     (about GC identifiers)

Start:
37,196,728 bp from pter      End:
37,215,523 bp from pter
Size:
18,796 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PRVA_HUMAN, P20472 (See protein sequence)
Recommended Name: Parvalbumin alpha  
Size: 110 amino acids; 12059 Da
Mass spectrometry: Mass=11927; Mass_error=0.76; Method=Electrospray; Range=2-110; Source=PubMed:10036163;
2 PDB 3D structures from and Proteopedia for PVALB:
1RJV (3D)        1RK9 (3D)    
Secondary accessions: B2R4H7 P78378 Q4VB78 Q5R3Q9

Explore the universe of human proteins at neXtProt for PVALB: NX_P20472

Explore proteomics data for PVALB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PVALB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002845.1  
    ENSEMBL proteins: 
     ENSP00000400247   ENSP00000216200   ENSP00000384735   ENSP00000386089   ENSP00000406977  

    PVALB Human Recombinant Protein Products:

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    Novus Biologicals PVALB Lysate
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    PVALB Antibody Products:

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    R&D Systems Antibodies for PVALB (Parvalbumin alpha)
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    LSBio Antibodies in human, mouse, rat for PVALB

    PVALB Assay Products:

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    Cloud-Clone Corp. ELISAs for PVALB
    Cloud-Clone Corp. CLIAs for PVALB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR008080 Parvalbumin
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P20472

    ProtoNet protein and cluster: P20472

    1 Blocks protein domain: IPB008080 Parvalbumin signature

    UniProtKB/Swiss-Prot: PRVA_HUMAN, P20472
    Similarity: Belongs to the parvalbumin family
    Similarity: Contains 2 EF-hand domains


    PVALB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRVA_HUMAN, P20472
    Function: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium
    ions

         Genatlas biochemistry entry for PVALB:
    parvalbumin,high affinity calcium binding protein,in muscle fibers IIB and GABAergic cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    PVALB for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PVALB:
     Increased G1 DNA content  Increased cell number in G2M,   Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Pvalb):
     behavior/neurological  cellular  muscle  nervous system  no phenotypic analysis 
     normal 

    PVALB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pvalbtm1Swal for PVALB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PVALB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PVALB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PVALB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PVALB

    miRNA
    Products:
        
    miRTarBase miRNAs that target PVALB:
    hsa-mir-26b-5p (MIRT028750)

    Block miRNA regulation of human, mouse, rat PVALB using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PVALB:
    hsa-miR-525-5p hsa-miR-4310 hsa-miR-766 hsa-miR-520a-5p hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidPVALB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PVALB
    Predesigned siRNA for gene silencing in human, mouse, rat PVALB

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PVALB (NM_002854)
    Sino Biological Human cDNA Clone for PVALB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PVALB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PVALB

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PVALB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    nucleus3
    cytosol2
    endoplasmic reticulum2
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0030424axon IEA--
    GO:0043234protein complex IEA--

    PVALB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PVALB
    Interactions:

        GeneGlobe Interaction Network for PVALB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for PVALB (ENSP000002162004) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PI4KBENSP000002716574STRING: ENSP00000271657
    PFKMENSP000003528424STRING: ENSP00000352842
    PPP3CAENSP000003783234STRING: ENSP00000378323
    TPM1ENSP000002679964STRING: ENSP00000267996
    MYL12AENSP000002176524STRING: ENSP00000217652
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051480cytosolic calcium ion homeostasis IEA--

    PVALB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PVALB (PRVA)

    1 HMDB Compound for PVALB    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for PVALB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Formic AcidAminic acid (see all 5)64-18-6target--10592235

    Selected Novoseek inferred chemical compound relationships for PVALB gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lant-6 72.6 4 8252409 (3), 9290931 (1)
    gaba 70.9 71 10501476 (3), 7953747 (3), 17375209 (3), 8252409 (2) (see all 39)
    calcium 65.6 205 8801253 (4), 1512554 (4), 10036163 (4), 7641793 (3) (see all 99)
    glutamate 60.9 40 8979811 (2), 8813295 (1), 14708030 (1), 17439984 (1) (see all 33)
    choline 56.7 21 10392842 (2), 9469576 (1), 10495446 (1), 15922606 (1) (see all 20)
    allergens 52.7 23 20232779 (3), 15147451 (2), 10637712 (1), 17272958 (1) (see all 19)
    nmda 40.7 10 16452684 (3), 8801253 (1), 9520096 (1), 20148871 (1) (see all 6)
    kainate 37.4 4 8752591 (2), 11074157 (1)
    tyrosine 26.9 20 20383714 (2), 10495446 (1), 10967083 (1), 14708030 (1) (see all 19)
    cyanine 25.3 2 10408601 (1), 14754864 (1)



    PVALB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PVALB gene: 
    NM_002854.2  

    Unigene Cluster for PVALB:

    Parvalbumin
    Hs.295449  [show with all ESTs]
    Unigene Representative Sequence: AA203126
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417718(uc010gwz.3) ENST00000216200(uc003apx.3) ENST00000406910
    ENST00000404171 ENST00000467935 ENST00000443735

    miRNA
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    Block miRNA regulation of human, mouse, rat PVALB using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PVALB:
    hsa-miR-525-5p hsa-miR-4310 hsa-miR-766 hsa-miR-520a-5p hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidPVALB 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PVALB
      QuantiTect SYBR Green Assays in human, mouse, rat PVALB
      QuantiFast Probe-based Assays in human, mouse, rat PVALB

    Additional mRNA sequence: 

    AK311832.1 BC069300.1 BC096112.3 BC096113.3 BC096114.1 BC096115.1 CR456552.1 X63070.1 

    3 DOTS entries:

    DT.116063  DT.92424907  DT.95086084 

    Selected AceView cDNA sequences (see all 98):

    X63070 AI003770 CR456552 AW139024 BP428769 AA010609 NM_002854 BX098124 
    BC069300 H47665 AI027079 BP431092 H92211 AI307387 BQ639294 AI767416 
    AI335012 H47585 AI861808 BQ638514 AA010608 AI022812 AI765610 H18303 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PVALB expression in normal human tissues (normalized intensities)      PVALB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGACAAGG
    PVALB Expression
    About this image


    PVALB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Kidney (Urinary System)
     
     Skeletal Muscle (Muscoskeletal System)
    PVALB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PVALB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.295449
        Custom PCR Arrays for PVALB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PVALB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PVALB gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pvalb1 , 5 parvalbumin1, 5 89.09(n)1
    87.27(a)1
      15 (36.93 cM)5
    192931  NM_013645.31  NP_038673.21 
     781911145 
    chicken
    (Gallus gallus)
    Aves PVALB1 parvalbumin 74.55(n)
    79.09(a)
      396459  NM_001159315.1  NP_001152787.1 
    lizard
    (Anolis carolinensis)
    Reptilia PVALB6
    parvalbumin
    79(a)
    1 ↔ 1
    5(22525081-22545720)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX724784.12   -- 76.47(n)    BX724784.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.141472 Danio rerio parvalbumin isoform 4b mRNA, complete cds 69.55(n)    AF467913.1 


    ENSEMBL Gene Tree for PVALB (if available)
    TreeFam Gene Tree for PVALB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PVALB gene
    OCM22  OCM2  
    10 SIMAP similar genes for PVALB using alignment to 4 protein entries:     PRVA_HUMAN (see all proteins):
    OCM2    OCM    CALN1    CALM1    CALM2    TNNC2
    CALM3    HZGJ    PPP3R1    PPP3R2

    PVALB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PVALB (see all 537)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs602498821,2
    C--20167620(+) ATCTT-/ATAGTAAA 1 -- int12Minor allele frequency- ATA:0.25NA 4
    rs1113663751,2
    C,F--37196293(+) TTTACC/ACATCT 1 -- ds50012Minor allele frequency- A:0.50NA 4
    rs48215281,2
    A--37196377(+) cccatC/Tcatcc 1 -- ds50010--------
    rs48215291,2
    C,F,H--37196448(+) TCAAAC/TCCCAA 1 -- ds500116Minor allele frequency- T:0.14NS EA NA WA CSA 794
    rs48215301,2
    C,F,H--37196459(+) CACTAA/GCAAAT 1 -- ds500112Minor allele frequency- G:0.44NS EA NA WA CSA 786
    rs57563491,2
    C,F,A,H--37196680(+) CCACCC/TCCTGC 1 -- ds500119Minor allele frequency- T:0.49NS EA NA WA 2342
    rs560104431,2
    --37196816(+) CAGGGA/GATGGG 1 -- ut310--------
    rs34841,2
    C,F,A,H--37196871(+) GTGGCA/GAGAGG 1 -- ut31 ese321Minor allele frequency- G:0.41MN NA PA EA WA EU 2249
    rs1818557701,2
    --37196879(+) AGGGGA/CCGAGA 1 -- ut310--------
    rs124839241,2
    C,H--37196905(+) AGAGAG/CGTGGA 1 -- ut314Minor allele frequency- C:0.00NS EA 420
    rs1134682361,2
    C--37196964(+) AATTCA/G/TGCAGA 1 -- spa11CSA 1
    rs20010631,2
    C,F,O,A,H--37196971(+) CAGAAC/AAAAAT 1 -- int125Minor allele frequency- A:0.48NS EA NA WA EU 3927
    rs780795901,2
    C,F--37196986(+) AGGAAA/GGTGAG 1 -- int11Minor allele frequency- G:0.10WA 118
    rs1868726891,2
    C--37196999(+) AGAGGC/TGGGGA 1 -- int10--------
    rs1893950941,2
    --37197219(+) TAATAA/GCTACA 1 -- int10--------
    rs48202491,2
    C,F,A,H--37197332(+) CAATAG/ATCCTG 1 -- int111Minor allele frequency- A:0.21NS EA NA WA CSA 784
    rs72907231,2
    C--37197464(+) GCCACG/TTGCCA 1 -- int10--------
    rs1165298751,2
    F--37197479(+) GTGTCT/CCTGAG 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1470352721,2
    --37197525(+) TCAGGA/CAAGTG 1 -- int10--------
    rs48202501,2
    C,F,A,H--37197530(+) CAAGTG/ACCCAT 1 -- int126Minor allele frequency- A:0.22NS EA NA WA CSA 2898
    rs1817586311,2
    --37197535(+) GCCCAA/TCGCCC 1 -- int10--------
    rs120537771,2
    H--37197543(+) CCCTAG/AAAAAT 1 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1851028011,2
    --37197613(+) CTGAGA/GCAGGT 1 -- int10--------
    rs48202511,2
    C,F,A--37197649(+) GACCAG/ACCTGG 1 -- int13Minor allele frequency- A:0.50NA CSA 6
    rs1409450041,2
    --37197758(+) AGAATA/TGCTTG 1 -- int10--------
    rs1899095811,2
    --37197816(+) TCCAGA/CTTGGG 1 -- int10--------
    rs2005526261,2
    --37197845(+) TCTCA-/AAAC  
            
    AAACA
    1 -- int10--------
    rs121598411,2
    C,F,H--37198175(+) ttagtT/Gttcat 1 -- int16Minor allele frequency- G:0.06NS EA WA CSA 422
    rs1133713711,2
    C,F--37198182(+) TCATCA/GTTGTA 1 -- int12Minor allele frequency- G:0.04CSA WA 120
    rs1502639751,2
    --37198213(+) AACATC/TGGGGG 1 -- int10--------
    rs130570421,2
    C,F,A,H--37198259(+) TCATTT/GCAATT 1 -- int113Minor allele frequency- G:0.21NS EA NA WA CSA 787
    rs590954331,2
    C,F--37198374(+) GGGCAC/AGGTGG 1 -- int16Minor allele frequency- A:0.12NA CSA WA EA 246
    rs130562581,2
    C,F,A--37198383(+) GGCTCA/GCTCCT 1 -- int16Minor allele frequency- G:0.45NA WA CSA 11
    rs121596801,2
    C,F--37198401(+) CAGCAT/CTTTGG 1 -- int15Minor allele frequency- C:0.30NA WA CSA 10
    rs1808563631,2
    --37198421(+) GTGGGC/TGGATC 1 -- int10--------
    rs130574391,2
    C,A--37198448(+) GAGACC/TATCCT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1864990241,2
    --37198513(+) GGTGGC/TGCACA 1 -- int10--------
    rs1913403241,2
    C--37198514(+) GTGGCA/GCACAC 1 -- int10--------
    rs1379361681,2
    --37198635(+) TGAGAC/TTCCAT 1 -- int10--------
    rs60004261,2
    C,A--37198647(+) TCACAA/CAAAAA 1 -- int12Minor allele frequency- C:0.00NA CSA 3
    rs81372831,2
    C,A--37198649(+) ACACAA/CAAAAA 1 -- int1 trp30--------
    rs81372881,2
    C--37198667(+) AAAAAA/GAAAGA 1 -- int1 trp30--------
    rs673884941,2
    C--37198668(+) AAAAA-/AA    
       AAG
    /G
    AAGAA
    1 -- int11NA 2
    rs608438631,2
    C--37198670(+) AAAAA-/A/    
       AGAAA
    GAAAG
    1 -- int11NA 2
    rs65190341,2
    C,F,A,H--37198709(+) TGAAGG/AGACAC 1 -- int126Minor allele frequency- A:0.18NS EA NA WA 2914
    rs1835242411,2
    --37198766(+) ATCATA/CCTTTC 1 -- int10--------
    rs1424121471,2
    --37198774(+) TTCCTA/GTCCCC 1 -- int10--------
    rs65190351,2
    C,F,A,H--37198876(+) CCAGGC/TTCTCT 1 -- int125Minor allele frequency- T:0.22NS EA NA WA CSA 2838
    rs1874006281,2
    --37198945(+) ATACTC/TGTACA 1 -- int10--------
    rs1459735771,2
    --37198963(+) TCCCAC/TAGGGC 1 -- int10--------
    rs1486020771,2
    C--37198972(+) GCAGGC/TGTCAA 1 -- int10--------
    rs1910706091,2
    --37198973(+) CAGGCA/GTCAAA 1 -- int10--------
    rs119139721,2
    C,F,H--37199002(+) AGGAGC/TCTGTG 1 -- int116Minor allele frequency- T:0.07NS EA NA WA 1594
    rs1411608881,2
    --37199016(+) TTCCAG/TGACCT 1 -- int10--------
    rs1507917861,2
    --37199017(+) TCCAGA/GACCTC 1 -- int10--------
    rs57503091,2
    C,F,A,H--37199022(+) GACCTC/TGGTGG 1 -- int122Minor allele frequency- T:0.32NS EA NA WA 2896
    rs582901801,2
    C,F--37199132(+) ATATAT/CTATCT 1 -- int12Minor allele frequency- C:0.06NA EA 240
    rs717751981,2
    C--37199134(+) ATATT-/ATCTCAT 1 -- int10--------
    rs1832180191,2
    --37199136(+) ATTATC/TTCATT 1 -- int10--------
    rs1878709081,2
    --37199165(+) CATGGA/GAGAGA 1 -- int10--------
    rs1915768861,2
    --37199400(+) AAATGA/GTCTTA 1 -- int10--------
    rs1843981421,2
    --37199412(+) TTATGC/TACTTA 1 -- int10--------
    rs1880857551,2
    --37199520(+) CACAGG/TAGGTG 1 -- int10--------
    rs22840191,2
    C,A,H--37199593(+) AGGGAC/TGGATG 1 -- int110Minor allele frequency- T:0.06WA NA CSA EA 370
    rs801424031,2
    C,F--37199649(+) GGAGGG/CATGAG 1 -- int11Minor allele frequency- C:0.14WA 118
    rs1392175941,2
    --37199669(+) GATAGA/GGGGAT 1 -- int10--------
    rs1476271841,2
    --37199749(+) GATGGA/GTGGAT 1 -- int10--------
    rs711932701,2
    C--37199756(+) GATGG-/ATGGA 
     TGGATGG
    GTGGG
    2 -- int1 cds11Minor allele frequency- ATGGATGGATGG:0.00NA 2
    rs20220681,2
    C,F,A,H--37199806(+) TAGGGA/GTCAAC 1 -- int136Minor allele frequency- N:0.00NS EA NA WA CSA 3084
    rs48215311,2
    C,F,A,H--37199947(+) GCCTCT/CGGCCT 1 -- int119Minor allele frequency- C:0.22NS EA WA NA CSA 2342
    rs18944791,2
    C,F,A,H--37200134(+) TCACCG/ACCTGC 1 -- int113Minor allele frequency- A:0.21NS EA NA CSA WA 2430
    rs1928486451,2
    C--37200317(+) GGGACA/CCCAAT 1 -- int10--------
    rs1852176391,2
    --37200335(+) TCTCCA/GGTGAC 1 -- int10--------
    rs72875591,2
    C,F--37200426(+) CTCTGC/ACCACC 1 -- int12Minor allele frequency- A:0.05WA 120
    rs600030861,2
    C,F--37200436(+) CCTGCA/CATCTG 1 -- int12Minor allele frequency- C:0.20WA 120
    rs72879991,2
    C,F--37200500(+) AACACG/AGAATT 1 -- int12Minor allele frequency- A:0.06WA 120
    rs96105861,2
    F--37200522(+) CCCTCA/CGAACC 1 -- int10--------
    rs1454064121,2
    --37200530(+) ACCTTC/TAATAG 1 -- int10--------
    rs1815535801,2
    --37200533(+) TTCAAC/TAGGGG 1 -- int10--------
    rs1452634801,2
    C--37200577(+) CTTCCA/GTGCCT 1 -- int10--------
    rs1848458051,2
    --37200612(+) TCTTAA/GGAGCC 1 -- int10--------
    rs1180492991,2
    C,F--37200629(+) TTAACG/AAACAG 1 -- int11Minor allele frequency- A:0.03NA 120
    rs72882901,2
    C,F,A,H--37200670(+) CCCAGG/TTCTCT 1 -- int110Minor allele frequency- T:0.22EA NS NA WA CSA 620
    rs1491328191,2
    --37200776(+) AGTTCA/GAGACC 1 -- int10--------
    rs1892657311,2
    --37200806(+) AACCTA/CGTCTC 1 -- int10--------
    rs22840201,2
    C--37200835(+) CAGCCG/AGGAGT 1 -- int18Minor allele frequency- A:0.29NA WA CSA EA 368
    rs1809862981,2
    --37200847(+) GTGGCA/GCGCGC 1 -- int10--------
    rs1173803771,2
    F--37200901(+) TGAACC/GCGGGA 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1422920281,2
    --37200902(+) GAACCC/TGGGAG 1 -- int10--------
    rs1513240961,2
    --37200925(+) GTGAGC/TTAAGA 1 -- int10--------
    rs1859770131,2
    --37200932(+) AAGATC/TACACC 1 -- int10--------
    rs1912408191,2
    --37201075(+) GGATGC/GGGAAT 1 -- int10--------
    rs1139735431,2
    C--37201198(+) GAAGAT/CGCCTT 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs1407482581,2
    --37201364(+) CTAAAG/TCTCTC 1 -- int10--------
    rs1458987481,2
    --37201412(+) GGTGGC/TGTTGC 1 -- int10--------
    rs121711251,2
    C,F,A,H--37201450(+) ACTTTA/GAAACC 1 -- int128Minor allele frequency- G:0.22NA NS EA WA CSA 2789
    rs1137623071,2
    C--37201467(+) ATAAAC/TGCCTA 1 -- int13Minor allele frequency- T:0.07CSA WA 121
    rs787222731,2
    F--37201498(+) GGAGGC/TTCTAA 1 -- int12Minor allele frequency- T:0.02CSA WA 120
    rs1811189391,2
    --37201551(+) GTTGCC/TATTGT 1 -- int10--------
    rs1861042541,2
    --37201589(+) CCTCCG/TCCCTG 1 -- int10--------
    rs1908226881,2
    --37201614(+) TCATCC/TAGCAA 1 -- int10--------
    rs284735141,2
    C--37201692(+) CTCTCC/TGAGGC 1 -- int10--------
    rs1829912381,2
    --37201709(+) TTCTCA/GTTTGT 1 -- int10--------
    rs1880184181,2
    --37201753(+) ATTAGA/GAAGAC 1 -- int10--------
    rs1921892351,2
    --37201810(+) TAGTTA/CCGCCT 1 -- int10--------
    rs22840211,2
    C,F,H--37201817(+) GCCTCC/TCGTGT 1 -- int123Minor allele frequency- T:0.22NS EA NA CSA WA 2764
    rs22840221,2
    C,F,A,H--37201891(+) GAAACT/CAAGCA 1 -- int122Minor allele frequency- C:0.30EA NS NA WA CSA 3093
    rs1140772181,2
    C,F--37201930(+) GGAAAG/ACCTAA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs124837851,2
    H--37201932(+) AAAGCC/TTAAAG 1 -- int10--------
    rs770593081,2
    C,F--37201977(+) ATCTAT/CCCCAT 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1383843401,2
    --37202016(+) CCATCC/TGTGGC 1 -- int10--------
    rs1413596491,2
    C--37202159(+) GGAATA/GCGACT 1 -- int10--------
    rs48202521,2
    C,F,A,H--37202179(+) CTTAAT/CGTTGA 1 -- int113Minor allele frequency- C:0.21NA NS EA WA CSA 795
    rs1446430961,2
    --37202214(+) TGGAGG/TTATCC 1 -- int10--------
    rs1385197571,2
    --37202278(+) AAATCC/GTCGCC 1 -- int10--------
    rs48202531,2
    C,F--37202319(+) CATCAT/CTGTCC 1 -- int19Minor allele frequency- C:0.19NA WA EA 504
    rs777778781,2
    F--37202376(+) AGGAGG/TCAGCA 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1492404311,2
    --37202473(+) AGGCCA/GCGGGG 1 -- int10--------
    rs1826488381,2
    C--37202475(+) GCCGCA/GGGGAT 1 -- int10--------
    rs1877238381,2
    --37202509(+) CAGGTA/GAGAGC 1 -- int10--------
    rs7629171,2
    C,F,O,A,H--37202548(+) TGAGCC/TGGCCA 1 -- int115Minor allele frequency- T:0.27MN NS EA NA WA CSA 1806
    rs1444632871,2
    --37202604(+) ACCGGC/GATGAA 1 -- int10--------
    rs1480593061,2
    --37202653(+) GCTCCC/TGGGCT 1 -- int10--------
    rs1436823121,2
    C--37202699(+) ACCTTC/TCCATC 1 -- int10--------
    rs7367211,2
    C,F,A,H--37202706(+) CATCCC/TGGAGA 1 -- int112Minor allele frequency- T:0.18NA EA NS WA 1017
    rs1472213061,2
    --37202717(+) ACTGGA/GAGGCA 1 -- int10--------
    rs7367201,2
    C,F,O,A,H--37202831(+) TCGTCG/AGCTCT 1 -- int130Minor allele frequency- A:0.27NA EA NS WA CSA 4033
    rs790981841,2
    C,F--37202890(+) TCACTC/TAGCTA 1 -- int12Minor allele frequency- T:0.04CSA WA 120
    rs1120156351,2
    C,F--37202924(+) GGGGCC/TAGGGT 1 -- int12Minor allele frequency- T:0.06CSA WA 120
    rs1404759981,2
    --37202986(+) TGCAAC/GCCCCA 1 -- int10--------
    rs1927183081,2
    --37203032(+) CTTTTC/TCCACC 1 -- int10--------
    rs1850816811,2
    --37203119(+) GTGCAA/GCATAA 1 -- int10--------
    rs1869872091,2
    --37203186(+) AAGCCA/GTTTAT 1 -- int10--------
    rs22840231,2
    C,F,H--37203297(+) TCTACG/AGGGCC 1 -- int112Minor allele frequency- A:0.23NS EA NA CSA WA 786
    rs1176664071,2
    C,F--37203300(+) ACGGGG/TCCTCA 1 -- int11Minor allele frequency- T:0.02NA 120
    rs60004271,2
    C,F--37203315(+) tcAAGT/CCTCTC 1 -- int11Minor allele frequency- C:0.01WA 118
    rs96224881,2
    C,F,A,H--37203327(+) GTGGGC/GATCAC 1 -- int113Minor allele frequency- G:0.18NS EA NA WA CSA 766
    rs1125714611,2
    F--37203329(+) GGGCAC/TCACAG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1131940991,2
    C,F--37203391(+) AGCATC/TGTGCA 1 -- int12Minor allele frequency- T:0.06CSA WA 120
    rs1115013661,2
    C,F--37203442(+) CTGAGC/TATCCT 1 -- int12Minor allele frequency- T:0.03CSA WA 120
    rs1123988341,2
    C--37203473(+) CCCCAC/TAGAGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1922372561,2
    --37203523(+) TTCTAA/TCTCTC 1 -- int10--------
    rs1842651511,2
    --37203637(+) AATAAG/TAGGAA 1 -- int10--------
    rs1506372221,2
    C--37203663(+) AACATC/TCTCTT 1 -- int10--------
    rs1180491811,2
    C--37203710(+) TCCCCA/GCTTTC 1 -- int11Minor allele frequency- G:0.01EA 120
    rs1894156721,2
    --37203767(+) CCCACA/GGCTGA 1 -- int10--------
    rs117051631,2
    C,F,H--37203961(+) CAAGGG/CGTGGG 1 -- int17Minor allele frequency- C:0.18NA WA EA 366
    rs1822447321,2
    --37203964(+) GGGGTC/GGGGGG 1 -- int10--------
    rs1843836841,2
    --37203979(+) CAAGGA/TTAGGC 1 -- int10--------
    rs75112161,2
    C,F,A,H--37204065(+) GCAGAG/AGGCAG 1 -- int12Minor allele frequency- A:0.05NS NA 234
    rs1149009241,2
    C,F--37204119(+) GACTGC/TGTGCA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1892687791,2
    --37204120(+) ACTGCA/GTGCAG 1 -- int10--------
    rs1808450691,2
    --37204216(+) CAAGTC/TGCTCT 1 -- int10--------
    rs1398218181,2
    --37204217(+) AAGTCC/GCTCTG 1 -- int10--------
    rs1497715461,2
    --37204226(+) TGCTTC/TCCGGG 1 -- int10--------
    rs22840241,2
    C,F,H--37204229(+) TTCCCT/GGGGCC 1 -- int117Minor allele frequency- G:0.06NS EA NA WA CSA 791
    rs1858481041,2
    --37204298(+) AATGAC/GTTAAA 1 -- int10--------
    rs1886048461,2
    --37204359(+) GCTAAC/TCTCGA 1 -- int10--------
    rs596781931,2
    C,F--37204388(+) CTCTGC/TGGGGG 1 -- int12Minor allele frequency- T:0.08WA 120
    rs1816826971,2
    --37204392(+) GCGGGC/GGCAGG 1 -- int10--------
    rs1445222821,2
    C--37204421(+) AGGCT-/GGGGGA 1 -- int10--------
    rs611997201,2
    C,F--37204623(+) TCGCCA/GGATCA 1 -- int13Minor allele frequency- G:0.23WA CSA 122
    rs1859778531,2
    --37204756(+) CCGCTC/TCCAGC 1 -- int10--------
    rs1456825951,2
    --37204768(+) GGAGAC/TCTGTT 1 -- int10--------
    rs1151048491,2
    F--37204907(+) CTTCTC/TTTTCC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1175527891,2
    C,F--37205054(+) TATTAT/CTAGAA 1 -- int11Minor allele frequency- C:0.02EA 120
    rs1405226801,2
    --37205076(+) TACCCC/GCTCCC 1 -- int10--------
    rs1444733171,2
    --37205116(+) AGTATC/TACTCA 1 -- int10--------
    rs561014551,2
    C--37205150(+) GGGAAG/AAGAGG 1 -- int17Minor allele frequency- A:0.25WA NA CSA EA 365
    rs770573481,2
    C,F--37205307(+) TCATTC/TATTCA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1919994481,2
    --37205354(+) TATGGC/GCCAGG 1 -- int10--------
    rs2014676691,2
    C--37205489(+) AAACT-/ATGA  
            
    ATGAA
    1 -- int10--------
    rs1171737761,2
    F--37205733(+) TTGAGC/TGCTCT 1 -- int11Minor allele frequency- T:0.03EA 120
    rs802308701,2
    C--37205735(+) GAGCGC/TTCTAT 1 -- int12Minor allele frequency- T:0.04CSA WA 120
    rs781359151,2
    C,F--37205847(+) AATCCC/TGGGGC 1 -- int11Minor allele frequency- T:0.07WA 118
    rs770488221,2
    F--37205848(+) ATCCCG/AGGGCT 1 -- int12Minor allele frequency- A:0.07CSA WA 120
    rs1151408581,2
    F--37205858(+) TGGAAC/TGCACC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs584516701,2
    C--37205900(+) TTTTT-/T/TTT 
            
    GGTTT
    2 -- int1 cds11NA 2
    rs117033171,2
    H--37205918(+) TTTTTG/TGtttt 1 -- int10--------
    rs1466408521,2
    C--37205969(+) TGCTGC/TCCAGG 1 -- int10--------
    rs1120113171,2
    F--37206048(+) CTCAGC/TCTCTT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1838804251,2
    --37206149(+) GTCTCG/TAACTC 1 -- int10--------
    rs48215321,2
    C,A,H--37206162(+) GACCTC/TGTGAT 1 -- int16Minor allele frequency- T:0.09NA WA CSA 11
    rs1113895551,2
    F--37206218(+) CACTGC/TGCCCG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs48215331,2
    C,F--37206292(+) GATCCC/TGCCAG 1 -- int15Minor allele frequency- T:0.13NA WA EA 362
    rs48202541,2
    C,F,A,H--37206341(+) CCTTCT/GGGCCT 1 -- int132Minor allele frequency- G:0.47NS EA NA WA CSA 3193
    rs1127976501,2
    F--37206387(+) CAGAAC/TGTCCT 1 -- int12Minor allele frequency- T:0.08CSA WA 120
    rs1871806871,2
    --37206388(+) AGAACA/GTCCTG 1 -- int10--------
    rs1402429111,2
    --37206524(+) GTGTGA/GGGCCC 1 -- int10--------
    rs1912012891,2
    --37206562(+) TGTCTA/GTTTTA 1 -- int10--------
    rs1821506491,2
    --37206717(+) CTGTTA/GTCCCA 1 -- int10--------
    rs1503241671,2
    --37206758(+) AGGCTG/TGACAC 1 -- int10--------
    rs96105871,2
    C,F,A,H--37206871(+) CAATAC/TCTTGC 1 -- int16Minor allele frequency- T:0.26NS NA WA EA 572
    rs1871141831,2
    C--37206897(+) TCTGTC/TCCCTA 1 -- int10--------
    rs1134675141,2
    C,F--37207078(+) ACTTTG/AGGAGG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs107757411,2
    C,F,A,H--37207180(+) CTGGGC/GATGGT 1 -- int16Minor allele frequency- G:0.18NA WA CSA 11
    rs119135111,2
    C,F,H--37207191(+) ggtgcA/Gtgcct 1 -- int11Minor allele frequency- G:0.00WA 2
    rs1389651471,2
    --37207232(+) GGGGGA/GAATTG 1 -- int10--------
    rs1410859011,2
    C--37207319(+) GTCTC-/TAAA/ 
    TAAATAAA
    TAAAT
    1 -- int10--------
    rs721647691,2
    C--37207320(+) GTCTC-/TAAA  
            
    TAAAT
    1 -- int10--------
    rs1130516161,2
    C--37207320(+) GTCTC-/TAAAT 
     AAATAAA
    TAAAT
    1 -- int11Minor allele frequency- TAAATAAATAAA:0.50CSA 2
    rs40842921,2
    C--37207354(+) AATAA-/ATAA/ 
    ATAAATAA
    GGCAT
    1 -- int10--------
    rs1915674601,2
    --37207415(+) CATTTC/TCATGT 1 -- int10--------
    rs1165678561,2
    C,F--37207484(+) AGGGGC/TACCCA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs342625001,2
    C,F--37207667(+) CTTCAT/ACAGGT 1 -- int110Minor allele frequency- A:0.40NA WA CSA EA 372
    rs1428008021,2
    --37207715(+) CAGGGA/CTTCTG 1 -- int10--------
    rs1829434711,2
    --37207723(+) CTGAGA/GTATGG 1 -- int10--------
    rs748342851,2
    C,F--37207920(+) TGCTCC/GACTCC 1 -- int12Minor allele frequency- G:0.07CSA WA 120
    rs622290871,2
    C,F--37207952(+) CCCAGC/ACACAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1123466561,2
    C--37207989(+) GGGGAC/ACCCCT 1 -- int12Minor allele frequency- A:0.08CSA WA 120
    rs1884952531,2
    --37208027(+) TTCTCA/GTTACT 1 -- int10--------
    rs1930997831,2
    C--37208077(+) AACAAA/CAAAAA 1 -- int10--------
    rs1126219601,2
    C--37208078(+) ACAACAA/-AAAAA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs731562621,2
    C,F--37208080(+) AACAAC/AAAAAA 1 -- int12Minor allele frequency- A:0.25NA 4
    rs7390311,2
    C,F,O,H--37208149(+) TTTTGT/GGTTCA 1 -- int121Minor allele frequency- G:0.16EA NA NS WA CSA 1143
    rs1484568161,2
    C--37208219(+) TTTGCC/TGGGCA 1 -- int10--------
    rs738840211,2
    C,F--37208238(+) TAGGTG/CTGCAG 1 -- int12Minor allele frequency- C:0.04WA 120
    rs1167860361,2
    F--37208533(+) ACATTT/CACTCT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs96224891,2
    C--37208648(+) GCTCAG/AAGTAG 1 -- int14Minor allele frequency- A:0.10NA WA EA 360
    rs57503101,2
    C,F,A,H--37208660(+) TATCAA/CATTAC 1 -- int120Minor allele frequency- C:0.40NS EA NA WA 2756
    rs113705311,2
    C--37208702(+) GATTTT/-GAACC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs57503111,2
    C,F,H--37208786(+) TGGGAG/ACAAAT 1 -- int114Minor allele frequency- A:0.08NS EA WA NA CSA 783
    rs48215341,2
    C,F,H--37208806(+) GTATGC/TTGCAA 1 -- int113Minor allele frequency- T:0.06NA WA CSA EA 513
    rs1423056591,2
    --37208854(+) CGCTAC/TGTCCT 1 -- int10--------
    rs1903478791,2
    --37208925(+) AATTCC/TGGAGA 1 -- int10--------
    rs794941381,2
    C,F--37208926(+) ATTCCG/AGAGAA 1 -- int11Minor allele frequency- A:0.09WA 118
    rs48215351,2
    C,F,A,H--37208952(+) GAGATG/AGCAAT 1 -- int115Minor allele frequency- A:0.08NS EA NA WA CSA 673
    rs1508561541,2
    --37208984(+) CACACA/GGAGCC 1 -- int10--------
    rs592083821,2
    F--37208995(+) AAATGG/TAGAAA 1 -- int11Minor allele frequency- T:0.03EA 120
    rs557118891,2
    --37209285(+) TAGTCA/GGCCTC 1 -- int10--------
    rs48202551,2
    C,F,A,H--37209296(+) ATTTCC/GTTGGA 1 -- int116Minor allele frequency- G:0.08NS EA NA WA CSA 791
    rs591151191,2
    C,F--37209435(+) TCCTCC/TTGGAT 1 -- int13Minor allele frequency- T:0.19WA CSA 122
    rs48215361,2
    C,F,A,H--37209447(+) CCCTAT/CCCAGC 1 -- int123Minor allele frequency- C:0.17NS EA NA WA CSA 2351
    rs1394825031,2
    --37209522(+) CTGGAA/GTATGT 1 -- int10--------
    rs1927784561,2
    --37209600(+) TCATCC/GCTTCC 1 -- int10--------
    rs2006101841,2
    C--37209691(+) CCACCA/GTCAAC 2 D syn10--------
    rs350954991,2
    C,F--37209762(+) AGACAG/AGTCTC 2 /L syn12Minor allele frequency- A:0.00NA 4622
    rs1995014631,2
    --37209800(+) TGAATC/TTGGAG 1 -- spa10--------
    rs1836948321,2
    C--37209823(+) AAAGCC/TGGTGA 1 -- int10--------
    rs2018145921,2
    --37209829(+) GGTGAA/GGGAGT 1 -- int10--------
    rs1887540951,2
    --37209876(+) GTGGTC/TTGGTT 1 -- int10--------
    rs1180632561,2
    C,F--37209947(+) TCTGGG/CCCAGG 1 -- int11Minor allele frequency- C:0.03EA 120
    rs779715631,2
    F--37209962(+) CTGCTC/TGGTGG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs20717091,2
    C,F,A,H--37209977(+) GCTTTC/TGTGGG 1 -- int111Minor allele frequency- T:0.13EA NS NA WA 2276
    rs1133427091,2
    C,F--37210047(+) GCACCT/CACATT 1 -- int13Minor allele frequency- C:0.12CSA WA 125
    rs1146492541,2
    F--37210173(+) GGCTCC/TGAGAG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1811347521,2
    --37210200(+) TGGGCC/TGTGGA 1 -- int10--------
    rs1466321501,2
    --37210213(+) AGGGCA/TCTCAG 1 -- int10--------
    rs1132012241,2
    C,F--37210294(+) ACAGGG/AGGAAG 1 -- int13Minor allele frequency- A:0.06NA WA 240
    rs713248281,2
    C--37210313(+) TGTGAGTGTGT/-
            
    GTGTG
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs22134281,2
    C,F,A--37210348(+) GTGTGC/TGCATA 1 -- int15Minor allele frequency- T:0.21NA CSA EA 246
    rs1861127301,2
    --37210351(+) TGTGCA/CTAAGT 1 -- int10--------
    rs20670691,2
    C,F,A,H--37210469(+) TGAAAG/AGCCTC 1 -- int18Minor allele frequency- A:0.38EA NS NA CSA WA 658
    rs20670681,2
    C,A--37210470(+) GAAAGG/ACCTCT 1 -- int15Minor allele frequency- A:0.42NA CSA WA EA 362
    rs1402036121,2
    --37210483(+) CTACAC/TCCACC 1 -- int10--------
    rs1904312811,2
    --37210492(+) CCCCCC/TGCTTC 1 -- int10--------
    rs22695111,2
    C,F,A,H--37210656(+) GCTTTC/TCTCCA 1 -- int133Minor allele frequency- T:0.32EA NS NA WA CSA 4680
    rs22695121,2
    C,F,A,H--37210677(+) GACTCC/TCAGAG 1 -- int112Minor allele frequency- T:0.32EA NS WA NA CSA 2106
    rs1498246431,2
    --37210816(+) TTTCTC/GCCCTG 1 -- int10--------
    rs734217231,2
    C,F--37210832(+) GGTGTT/CAGGCA 1 -- int14Minor allele frequency- C:0.18WA CSA 126
    rs738840231,2
    C,F--37210844(+) CAAGAA/CAACTG 1 -- int12Minor allele frequency- C:0.06WA 120
    rs1457895801,2
    --37210857(+) TCTTCA/GTTTGC 1 -- int10--------
    rs1817033341,2
    --37210860(+) TCATTC/TGCATT 1 -- int10--------
    rs1489836421,2
    --37210988(+) TCCCCC/TGGTGC 1 -- int10--------
    rs1434801941,2
    --37211022(+) CGCACA/GGTTAC 1 -- int10--------
    rs1146299081,2
    C,F--37211074(+) ACTTGG/CAAGCT 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1876288701,2
    --37211094(+) GCCCCC/GACTCC 1 -- int10--------
    rs2006683311,2
    C--37211105(+) CTCTCC/GTGCAG 1 -- int10--------
    rs2001053451,2
    C--37211117(+) CGTGGA/GCTGGG 1 -- int10--------
    rs2020760541,2
    --37211141(+) CCTCCC/GCTTAC 1 -- int10--------
    rs1475960871,2
    C,F--37211148(+) TTACCC/TCAGCT 2 R G mis12Minor allele frequency- T:0.01NA EU 5825
    rs2013604531,2
    --37211155(+) AGCTCA/GTCCTC 2 D syn10--------
    rs1379282601,2
    C--37211163(+) CTCCTC/TGATGA 2 K E mis11Minor allele frequency- T:0.00NA 4550
    rs748043221,2
    C,F--37211219(+) CATCCG/ACACTC 2 /A /V mis13Minor allele frequency- A:0.01WA NA EU 5991
    rs1419446391,2
    C--37211286(+) TGTGGC/GGGGAA 1 -- int10--------
    rs2016494171,2
    --37211287(+) GTGGGG/TGGAAG 1 -- int10--------
    rs1458091941,2
    C--37211289(+) GGGGGG/TAAGAG 1 -- int11Minor allele frequency- T:0.00EU 1323
    rs2003508321,2
    --37211324(+) GCTGGC/TAGGGA 1 -- int10--------
    rs130544481,2
    C,F--37211331(+) GGGAAG/ACCTGG 1 -- int12Minor allele frequency- A:0.50NA 4
    rs1412967511,2
    --37211374(+) GATTCC/TCACAT 1 -- int10--------
    rs1918944471,2
    --37211437(+) CCGGGC/TAAGGG 1 -- int10--------
    rs1822746821,2
    --37211447(+) GAGGAA/TAACCT 1 -- int10--------
    rs48202561,2
    C,H--37211529(+) CCCACA/GCCCCA 1 -- int114Minor allele frequency- G:0.00EA NA WA CSA 553
    rs1148284491,2
    C,F--37211673(+) CATGAA/GCATGG 1 -- int11Minor allele frequency- G:0.01WA 118
    rs792743871,2
    F--37211803(+) AACCCG/AGAAGT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1503782381,2
    --37211820(+) TCTGCA/GCAGAA 1 -- int10--------
    rs1380147981,2
    C--37211835(+) ACTTCA/GGAGGC 1 -- int10--------
    rs283724021,2
    C,F--37212015(+) TTTTCC/TACCTG 1 -- int10--------
    rs106050261,2
    C--37212087(+) GTATT-/TTgtgtg 1 -- int10--------
    rs7390321,2
    C,A--37212089(+) GTATTG/TTGTGT 1 -- int15Minor allele frequency- T:0.12NA WA CSA 8
    rs584740741,2
    C,F--37212111(+) TGTGTG/ATGTGT 1 -- int12Minor allele frequency- A:0.05WA NA 238
    rs1495151921,2
    --37212146(+) GTTCTC/TTTCCC 1 -- int10--------
    rs119132671,2
    C,F,H--37212154(+) CCCCTC/TAGCAC 1 -- int1 trp34Minor allele frequency- T:0.18WA NA EA 360
    rs1447229261,2
    C--37212164(+) CAGGGC/TTAGAG 1 -- int10--------
    rs1996742821,2
    --37212165(+) GGGCT-/AGAGAGA 1 -- int10--------
    rs731562671,2
    C--37212335(+) CTTAGC/TGCTGA 1 -- int10--------
    rs2006058111,2
    --37212472(+) AGGTC-/ACCTCG 1 -- int10--------
    rs7629201,2
    C,F,A,H--37212536(+) AACAAC/AGGCTA 1 -- int120Minor allele frequency- A:0.08EA NA MN NS WA CSA 1016
    rs1427567091,2
    C--37212708(+) TTGGTC/GCCGGA 1 -- int10--------
    rs1181691941,2
    C,F--37212945(+) GGGCGG/TTGGAC 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1996875771,2
    --37212950(+) GTGGAC/GGAGGG 1 -- int10--------
    rs2014271391,2
    --37213062(+) CTGTTC/TGAGCG 1 -- int10--------
    rs1901348081,2
    --37213240(+) GCAGCG/TCCGGC 1 -- int10--------
    rs1460761241,2
    --37213266(+) GCGCGA/GACCTG 1 -- int10--------
    rs738840241,2
    C,F--37213386(+) CTGGGT/CCTGGA 1 -- int13Minor allele frequency- C:0.22WA EA 240
    rs1823722851,2
    --37213473(+) TGGGGG/TAAGAT 1 -- int10--------
    rs1400265801,2
    --37213771(+) TTATTC/TTTTTG 1 -- int10--------
    rs1879649881,2
    --37213843(+) CCTGGA/GTCCTG 1 -- int10--------
    rs1424362701,2
    --37213871(+) TCCCCA/CTACTC 1 -- int10--------
    rs1513303011,2
    --37213915(+) GAGTCC/TGCTTG 1 -- int10--------
    rs57503131,2
    C--37214172(+) gggttA/C/Ttagat 1 -- int11NA 2
    rs792377651,2
    C,F--37214179(+) AGATCC/ATGGGC 1 -- int12Minor allele frequency- A:0.06WA NA 238
    rs783616181,2
    C,F--37214180(+) GATCCT/CGGGCT 1 -- int12Minor allele frequency- C:0.07WA NA 238
    rs1393438701,2
    --37214193(+) ACTAAG/TTCCCA 1 -- int10--------
    rs22840251,2
    C,F,A,H--37214435(+) GCCCTG/AGATGG 1 -- int110Minor allele frequency- A:0.15EA NS WA CSA NA 2164
    rs1931947841,2
    --37214508(+) AGCTCC/TTTCAA 1 -- int10--------
    rs1500446521,2
    C--37214569(+) CTGATA/GCCTCT 1 -- int10--------
    rs1833511031,2
    --37214607(+) AGCTGA/CCCTGG 1 -- int10--------
    rs1891588121,2
    --37214659(+) CTGGGC/TTGCTG 1 -- int10--------
    rs1924193951,2
    --37214701(+) TTCAAC/TTCCCA 1 -- int10--------
    rs22840261,2
    C,F,A,H--37214721(+) CACTCT/CAGGAG 1 -- int113Minor allele frequency- C:0.35NA EA CSA WA 731
    rs1838458941,2
    --37214762(+) AGGACA/GCTTCA 1 -- int10--------
    rs1866210811,2
    --37214802(+) AGTCCA/GTGAAT 1 -- int10--------
    rs1131108341,2
    F--37214848(+) GGGTAC/AACCCC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1850566991,2
    --37214990(+) GCAAAA/GGCTGC 1 -- int10--------
    rs1895189881,2
    --37215082(+) CCCTCC/TGGGAC 1 -- int10--------
    rs1475860561,2
    --37215216(+) CTCTCA/GTTCTA 1 -- int10--------
    rs1820919931,2
    --37215255(+) GGGGGC/TGGTGG 1 -- int10--------
    rs1168830071,2
    C,F--37215282(+) CCAGGC/ACACAC 1 -- int11Minor allele frequency- A:0.02EA 120
    rs1421129241,2
    --37215482(+) CGGGTA/GGGGGT 1 -- ut510--------
    rs1458731261,2
    C--37215611(+) CTCCCC/TGTAGC 1 -- us2k10--------
    rs1477603991,2
    --37215619(+) AGCCCC/TGGCCC 1 -- us2k10--------
    rs59953461,2
    C--37215683(+) ACATTC/TAGCCT 1 -- us2k