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PVALB Gene

protein-coding GIFtS: 59
GCID: GC22M037196

Parvalbumin

See PVALB-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
parvalbumin¹ ²
D22S749²
Parvalbumin Alpha²

External Ids:	HGNC: 9704¹	Entrez Gene: 5816²	Ensembl: ENSG00000100362⁷	OMIM: 168890⁵	UniProtKB: P20472³

ORGUL members:

Export aliases for PVALB gene to outside databases

Previous GC identifers: GC22M033811 GC22M035439 GC22M035521 GC22M020159

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PVALB Gene:

The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and

functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle

relaxation. (provided by RefSeq, Jul 2008)

GeneCards Summary for PVALB Gene:

PVALB (parvalbumin) is a protein-coding gene. Diseases associated with PVALB include subcortical band heterotopia, and fetal alcohol syndrome. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is OCM2.

UniProtKB/Swiss-Prot: PRVA_HUMAN, P20472

Function: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium

ions

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000022.10 NT_011520.13 NT_187631.1 NC_018933.2

Regulatory elements:

Regulatory transcription factor binding sites in the PVALB gene promoter:
Pax-5 AML1a Lmo2 XBP-1 IRF-1 AP-4 Nkx2-5 E47 MZF-1 Cart-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PVALB promoter sequence

Search Chromatin IP Primers for PVALB

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PVALB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q13.1

PVALB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PVALB gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M037196: view genomic region (about GC identifiers)

Start:	37,196,728 bp from pter	End:	37,215,523 bp from pter
Size:	18,796 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRVA_HUMAN, P20472 (See protein sequence)

Recommended Name: Parvalbumin alpha

Size: 110 amino acids; 12059 Da

Mass spectrometry: Mass=11927; Mass_error=0.76; Method=Electrospray; Range=2-110; Source=PubMed:10036163;

2 PDB 3D structures from and Proteopedia for PVALB:

1RJV (3D)

1RK9 (3D)

Secondary accessions: B2R4H7 P78378 Q4VB78 Q5R3Q9

Explore the universe of human proteins at neXtProt for PVALB: NX_P20472

Explore proteomics data for PVALB at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See PVALB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002845.1

ENSEMBL proteins:

ENSP00000400247 ENSP00000216200 ENSP00000384735 ENSP00000386089 ENSP00000406977

PVALB Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for PVALB
	Cloud-Clone Corp. Proteins for PVALB
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	antibodies-online proteins for PVALB (31 products)
	antibodies-online peptides for PVALB

PVALB Antibody Products:

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	Novus Biologicals PVALB Antibodies
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	ThermoFisher Antibody for PVALB
	antibodies-online antibodies for PVALB (48 products)

PVALB Assay Products:

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	Cloud-Clone Corp. ELISAs for PVALB Cloud-Clone Corp. CLIAs for PVALB
	Search eBioscience for ELISAs for PVALB
	antibodies-online kits for PVALB (16 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

EFHAND: EF-hand domain containing

4 InterPro protein domains:

IPR011992 EF-hand-dom_pair

IPR002048 EF_hand_dom

IPR008080 Parvalbumin

IPR018247 EF_Hand_1_Ca_BS

Graphical View of Domain Structure for InterPro Entry P20472

ProtoNet protein and cluster: P20472

1 Blocks protein domain: IPB008080 Parvalbumin signature

UniProtKB/Swiss-Prot: PRVA_HUMAN, P20472

Similarity: Belongs to the parvalbumin family

Similarity: Contains 2 EF-hand domains

Find genes that share domains with PVALB About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: PRVA_HUMAN, P20472

Function: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium

ions

Genatlas biochemistry entry for PVALB:

parvalbumin,high affinity calcium binding protein,in muscle fibers IIB and GABAergic cells

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0042803	protein homodimerization activity	IEA	--
GO:0046982	protein heterodimerization activity	IEA	--

Find genes that share ontologies with PVALB About GenesLikeMe

Phenotypes:
3 GenomeRNAi human phenotypes for PVALB:

Increased G1 DNA content

Increased cell number in G2M,

Increased gamma-H2AX phosphory

6 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Pvalb):

behavior/neurological	cellular	muscle	nervous system	no phenotypic analysis
normal

Find genes that share phenotypes with PVALB About GenesLikeMe

Animal Models:
MGI mouse knock-out Pvalb^tm1Swal for PVALB

genOway: Develop your customized and physiologically relevant rodent model for PVALB

miRNA Products:		miRTarBase miRNAs that target PVALB: hsa-mir-26b-5p (MIRT028750)

		Block miRNA regulation of human, mouse, rat PVALB using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate PVALB:
		hsa-miR-525-5p hsa-miR-4310 hsa-miR-766 hsa-miR-520a-5p hsa-miR-338-3p
		SwitchGear 3'UTR luciferase reporter plasmid: PVALB 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PVALB
		Predesigned siRNA for gene silencing in human, mouse, rat PVALB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PVALB

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PVALB

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	3
nucleus	3
cytosol	2
endoplasmic reticulum	2
extracellular	1
mitochondrion	1
plasma membrane	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0030424	axon	IEA	--
GO:0043234	protein complex	IEA	--

Find genes that share ontologies with PVALB About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for PVALB
Interactions:

GeneGlobe Interaction Network for PVALB

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for PVALB (ENSP00000216200⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PI4KB	ENSP00000271657⁴	STRING: ENSP00000271657
PFKM	ENSP00000352842⁴	STRING: ENSP00000352842
PPP3CA	ENSP00000378323⁴	STRING: ENSP00000378323
TPM1	ENSP00000267996⁴	STRING: ENSP00000267996
MYL12A	ENSP00000217652⁴	STRING: ENSP00000217652

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0051480	cytosolic calcium ion homeostasis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for PVALB (PRVA)

1 HMDB Compound for PVALB About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for PVALB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Formic Acid	Aminic acid (see all 5)	64-18-6	target	--	10592235

Selected Novoseek inferred chemical compound relationships for PVALB gene (see all 45) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lant-6	72.6	4	8252409 (3), 9290931 (1)
gaba	70.9	71	10501476 (3), 7953747 (3), 17375209 (3), 8252409 (2) (see all 39)
calcium	65.6	205	8801253 (4), 1512554 (4), 10036163 (4), 7641793 (3) (see all 99)
glutamate	60.9	40	8979811 (2), 8813295 (1), 14708030 (1), 17439984 (1) (see all 33)
choline	56.7	21	10392842 (2), 9469576 (1), 10495446 (1), 15922606 (1) (see all 20)
allergens	52.7	23	20232779 (3), 15147451 (2), 10637712 (1), 17272958 (1) (see all 19)
nmda	40.7	10	16452684 (3), 8801253 (1), 9520096 (1), 20148871 (1) (see all 6)
kainate	37.4	4	8752591 (2), 11074157 (1)
tyrosine	26.9	20	20383714 (2), 10495446 (1), 10967083 (1), 14708030 (1) (see all 19)
cyanine	25.3	2	10408601 (1), 14754864 (1)

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PVALB gene:

NM_002854.2

Unigene Cluster for PVALB:

Parvalbumin

Hs.295449 [show with all ESTs]

Unigene Representative Sequence: AA203126

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000417718(uc010gwz.3) ENST00000216200(uc003apx.3) ENST00000406910

ENST00000404171 ENST00000467935 ENST00000443735

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		5 qRT-PCR Assays for microRNAs that regulate PVALB:
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		SwitchGear 3'UTR luciferase reporter plasmid: PVALB 3' UTR sequence

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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat PVALB
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		QuantiFast Probe-based Assays in human, mouse, rat PVALB

Additional mRNA sequence:

AK311832.1 BC069300.1 BC096112.3 BC096113.3 BC096114.1 BC096115.1 CR456552.1 X63070.1

3 DOTS entries:

DT.116063 DT.92424907 DT.95086084

Selected AceView cDNA sequences (see all 98):

X63070 AI003770 CR456552 AW139024 BP428769 AA010609 NM_002854 BX098124

BC069300 H47665 AI027079 BP431092 H92211 AI307387 BQ639294 AI767416

AI335012 H47585 AI861808 BQ638514 AA010608 AI022812 AI765610 H18303

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PVALB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTGGACAAGG

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PVALB expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Brain (Nervous System) fully expand to see all 3 entries
Midbrain tegmentum

Adipose (Muscoskeletal System)
Interscapular Brown Adipose Depot

Neural Tube (Nervous System)
Metencephalon

Kidney (Urinary System)

Skeletal Muscle (Muscoskeletal System)

PVALB Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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PVALB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.295449

Custom PCR Arrays for PVALB

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for PVALB gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pvalb^{1 , 5}	parvalbumin^{1, 5}	89.09(n)¹ 87.27(a)¹		15 (36.93 cM)⁵ 19293¹ NM_013645.3¹ NP_038673.2¹ 78191114⁵
chicken (Gallus gallus)	Aves	PVALB¹	parvalbumin	74.55(n) 79.09(a)		396459 NM_001159315.1 NP_001152787.1
lizard (Anolis carolinensis)	Reptilia	PVALB⁶	parvalbumin	79(a)	1 ↔ 1	5(22525081-22545720)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX724784.1²	--	76.47(n)		BX724784.1
zebrafish (Danio rerio)	Actinopterygii	Dr.14147²	Danio rerio parvalbumin isoform 4b mRNA, complete cds	69.55(n)		AF467913.1

ENSEMBL Gene Tree for PVALB (if available)
TreeFam Gene Tree for PVALB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PVALB gene

OCM2² OCM²

10 SIMAP similar genes for PVALB using alignment to 4 protein entries: PRVA_HUMAN (see all proteins):

OCM2 OCM CALN1 CALM1 CALM2 TNNC2

CALM3 HZGJ PPP3R1 PPP3R2

Find genes that share paralogs with PVALB About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60249882^1,2	C	--	20167620(+)	`ATCTT-/ATAGTAAA`	1	--	int¹		2		NA	4
rs111366375^1,2	C,F	--	37196293(+)	`TTTACC/ACATCT`	1	--	ds500¹		2		NA	4
rs4821528^1,2	A	--	37196377(+)	`cccatC/Tcatcc`	1	--	ds500¹		0	--	--	--	--
rs4821529^1,2	C,F,H	--	37196448(+)	`TCAAAC/TCCCAA`	1	--	ds500¹		16		NS EA NA WA CSA	794
rs4821530^1,2	C,F,H	--	37196459(+)	`CACTAA/GCAAAT`	1	--	ds500¹		12		NS EA NA WA CSA	786
rs5756349^1,2	C,F,A,H	--	37196680(+)	`CCACCC/TCCTGC`	1	--	ds500¹		19		NS EA NA WA	2342
rs56010443^1,2		--	37196816(+)	`CAGGGA/GATGGG`	1	--	ut3¹		0	--	--	--	--
rs3484^1,2	C,F,A,H	--	37196871(+)	`GTGGCA/GAGAGG`	1	--	ut3¹ ese³		21		MN NA PA EA WA EU	2249
rs181855770^1,2		--	37196879(+)	`AGGGGA/CCGAGA`	1	--	ut3¹		0	--	--	--	--
rs12483924^1,2	C,H	--	37196905(+)	`AGAGAG/CGTGGA`	1	--	ut3¹		4		NS EA	420

HapMap Linkage Disequilibrium report for PVALB (37196728 - 37215523 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for PVALB: About this table

Variant ID	Type	Subtype	PubMed ID
nsv3618	CNV	Insertion	18451855
nsv522590	CNV	Loss	19592680
nsv3617	CNV	Loss	18451855
dgv1403e1	CNV	Complex	17122850
dgv1404e1	CNV	Complex	17122850
dgv1405e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PVALB

DNA2.0 Custom Variant and Variant Library Synthesis for PVALB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 168890 OMIM disorders: --

9 diseases for PVALB (see first 20):
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subcortical band heterotopia fetal alcohol syndrome gangliocytoma schizophrenia

parkinson's disease synucleinopathy oxyphilic adenoma neuronal ceroid-lipofuscinoses

west syndrome

7 inferred disease relationships from the University of Copenhagen DISEASES database for PVALB:

Schizophrenia Neurodegenerative disease Brain disease Hypersensitivity reaction type I disease

Tetanus Oxyphilic adenoma Renal oncocytoma

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Selected Novoseek inferred disease relationships for PVALB gene (see all 57) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oncocytoma	63.7	13	16927643 (6), 11337362 (1), 14695146 (1), 16166433 (1) (see all 7)
epilepsy temporal lobe	54.9	3	1865007 (1), 9329455 (1), 16822257 (1)
schizophrenia	48	18	11532725 (2), 12589379 (2), 15555777 (1), 11955958 (1) (see all 16)
epilepsy	47	10	17535552 (1), 8064311 (1), 18562329 (1), 17267178 (1) (see all 7)
fetal alcohol syndrome	39.9	2	19251116 (1)
neurodegeneration	39.1	2	10448425 (1), 15043712 (1)
allergy	38.2	7	15696099 (1), 19398906 (1), 12783765 (1), 11971005 (1) (see all 7)
carcinoma renal cell	35.5	11	15286660 (4), 11504835 (3), 16927643 (1), 16512599 (1)
gliosis	35.3	1	17485991 (1)
neurofibrillary tangles	34.9	2	1717900 (2)

Genetic Association Database (GAD): PVALB

Export disorders for PVALB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PVALB gene, integrated from 10 sources (see all 516):
(articles sorted by number of sources associating them with PVALB)

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The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2, 3} Dunham I.... Wright H. (Nature 1999)
Electrospray ionization mass spectrometry: analysis of the Ca2+- binding properties of human recombinant alpha-parvalbumin and nine mutant proteins. (PubMed id 10036163)^{1, 2, 9} Troxler H.... Heizmann C.W. (Anal. Biochem. 1999)
Human alpha and beta parvalbumins. Structure and tissue-specific expression. (PubMed id 8354278)^{1, 2, 9} Foehr U.G.... Heizmann C.W. (Eur. J. Biochem. 1993)
The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. (PubMed id 1559707)^{1, 3, 9} Ritzler J.M....Berchtold M.W. (Genomics 1992)
A genome-wide association study of female sexual dysfunction. (PubMed id 22509378)^{1, 4} Burri A....Spector T.D. (PLoS ONE 2012)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (Genome Biol. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Parvalbumin genes from human and rat are identical in intron/exon organization and contain highly homologous regulatory elements and coding sequences. (PubMed id 2614829)^{1, 2} Berchtold M.W. (J. Mol. Biol. 1989)
Evaluating PVALB as a candidate gene for SLC12A3-negative cases of Gitelman's syndrome. (PubMed id 18469313)^{1, 9} Riveira-Munoz E....Dahan K. (Nephrol. Dial. Transplant. 2008)
Distribution of parvalbumin and calretinin immunoreactive interneurons in motor cortex from multiple sclerosis post-mortem tissue. (PubMed id 18297277)^{1, 9} Clements R.J....Freeman E.J. (Exp Brain Res 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5816	HGNC: 9704	AceView: PVALB	Ensembl:ENSG00000100362	euGenes: HUgn5816
ECgene: PVALB	H-InvDB: PVALB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PVALB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PVALB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PVALB gene:
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