PVALB Gene
protein-coding GIFtS : 54
GCID: GC22 M037196
parvalbumin
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Aliasesfor PVALB gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Parvalbumin 1 D22S7491 2 Parvalbumin Alpha2
Export aliases for PVALB gene to outside databases Previous GC identifers: GC22M033811 GC22M035439 GC22M035521 GC22M020159
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Summariesfor PVALB gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PVALB : The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: PRVA_HUMAN, P20472 Function : In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions
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Genomic Viewsfor PVALB gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000022.10 NC_018933.1 NT_011520.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PVALB gene promoter: Pax-5 AML1a Lmo2 XBP-1 IRF-1 AP-4 Nkx2-5 E47 MZF-1 Cart-1 Other transcription factors Search SABiosciences Chromatin IP Primers for PVALB Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat PVALB
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q13.1 PVALB Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22M037196: view genomic region
(about GC identifiers )
Start:
37,196,728 bp from pter
End:
37,215,523 bp from pter
Size:
18,796 bases
Orientation:
minus strand
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Proteinsfor PVALB gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PRVA_HUMAN, P20472 (See
protein sequence )Recommended Name: Parvalbumin alpha Size : 110 amino acids; 12059 Da
Mass spectrometry : Mass=11927; Mass_error=0.76; Method=Electrospray; Range=2-110; Source=PubMed:10036163;
2 PDB 3D structures from and Proteopedia for PVALB :1RJV (3D)
  1RK9 (3D)
 
Secondary accessions : B2R4H7 P78378 Q4VB78 Q5R3Q9Explore the universe of human proteins at neXtProt for PVALB: NX_P20472 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P20472 PVALB Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_002845.1 ENSEMBL proteins: ENSP00000400247 ENSP00000216200 ENSP00000384735 ENSP00000386089 ENSP00000406977 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
PVALB for ontologies About GeneDecksing PVALB Antibody Products: Assay Products for PVALB:
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Protein
Domains / Familiesfor PVALB gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
PVALB for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P20472 ProtoNet protein and cluster: P20472
1 Blocks protein family : IPB008080 Parvalbumin signature UniProtKB/Swiss-Prot: PRVA_HUMAN, P20472 Similarity : Belongs to the parvalbumin familySimilarity : Contains 2 EF-hand domains
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Functionfor PVALB gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PRVA_HUMAN, P20472 Function : In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions
Genatlas biochemistry entry for PVALB : parvalbumin,high affinity calcium binding protein,in muscle fibers IIB and GABAergic cells Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PVALB (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PVALBOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PVALB (NM_002854 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PVALB Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PVALB
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005509 calcium ion binding
IEA --
PVALB for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for PVALB :Animal Models: Mouse knock-out Pvalb tm1Swal for PVALB 6 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Pvalb) :
PVALB for phenotypes About GeneDecksing
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Pathways & Interactionsfor PVALB gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PVALB
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Drugs & Compoundsfor PVALB gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
PVALB for compounds About GeneDecksing Browse Tocris compounds for PVALB 1 HMDB Compound for PVALB About this table 1 DrugBank Compound for PVALB About this table 10/45 Novoseek chemical compound relationships for PVALB gene (see all 45 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
lant-6
72.6
4
8252409 (3), 9290931 (1)
gaba
70.9
71
10501476 (3), 7953747 (3), 17375209 (3), 8252409 (2) (see all 39 )
calcium
65.6
205
8801253 (4), 1512554 (4), 10036163 (4), 7641793 (3) (see all 99 )
glutamate
60.9
40
8979811 (2), 8813295 (1), 14708030 (1), 17439984 (1) (see all 33 )
choline
56.7
21
10392842 (2), 9469576 (1), 10495446 (1), 15922606 (1) (see all 20 )
allergens
52.7
23
20232779 (3), 15147451 (2), 10637712 (1), 17272958 (1) (see all 19 )
nmda
40.7
10
16452684 (3), 8801253 (1), 9520096 (1), 20148871 (1) (see all 6 )
kainate
37.4
4
8752591 (2), 11074157 (1)
tyrosine
26.9
20
20383714 (2), 10495446 (1), 10967083 (1), 14708030 (1) (see all 19 )
cyanine
25.3
2
10408601 (1), 14754864 (1)
Search CenterWatch for drugs/clinical trials and news about PVALB / PRVA
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Transcriptsfor PVALB gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PVALB gene: NM_002854.2 Unigene Cluster for PVALB:
Parvalbumin Hs.295449 [show with all ESTs ] Unigene Representative Sequence: AA203126 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000417718 (uc010gwz.3 ) ENST00000216200 (uc003apx.3 ) ENST00000406910 ENST00000404171 ENST00000467935 ENST00000443735 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PVALB (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PVALBOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PVALB (NM_002854 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PVALB Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PVALB
Additional cDNA sequence: AK311832.1 BC069300.1 BC096112.3 BC096113.3 BC096114.1 BC096115.1 CR456552.1 X63070.1
3 DOTS entries : DT.116063 DT.92424907
DT.95086084 24/98 AceView cDNA sequences (see all 98 ):
AW139024 AA010609 NM_002854 BC069300 X63070 CR456552 H47665 BX098124 AI003770 BP428769 AI022812 H92210 AI765610 AW271690 W63631 AI948673 AA010608 BQ638514 BM687969 H18303 AI027079 AI057566 H47585 BP431092 GeneLoc Exon Structure
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Expression for PVALB gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PVALB expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTGGACAAGG
About this image PVALB expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See PVALB Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PVALB SOURCE GeneReport for Unigene cluster: Hs.295449 SABiosciences Custom PCR Arrays for PVALB Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for PVALBBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat PVALB QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat PVALB QIAGEN QuantiFast Probe-based Assays in human , mouse , rat PVALB
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Orthologsfor PVALB gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for PVALB gene from 5/11 species (see all 11 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Pvalb1 , 5
parvalbumin1, 5
89.09(n) 1 87.27(a) 1
 
15 (36.93 cM) 5 19293 1 NM_013645.3 1 NP_038673.2 1 78191114 5
chicken (Gallus gallus)
Aves
PVALB1
parvalbumin
74.55(n) 79.09(a)
 
396459 NM_001159315.1 NP_001152787.1
lizard (Anolis carolinensis)
Reptilia
PVALB6
--
79(a)
1 ↔ 1
5(22525081-22545708)
tropical clawed frog (Xenopus tropicalis)
Amphibia
BX724784.12
--
76.47(n)
 
BX724784.1
zebrafish (Danio rerio)
Actinopterygii
Dr.141472
Danio rerio parvalbumin isoform 4b mRNA, complete cds
69.55(n)
 
AF467913.1
ENSEMBL Gene Tree for PVALB (if available)TreeFam Gene Tree for PVALB (if available)
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Paralogsfor PVALB gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PVALB gene OCM2 2 OCM 2 10 SIMAP similar genes for PVALB using alignment to 4 protein entries: PRVA_HUMAN (see all proteins ):OCM2 OCM CALN1 CALM1 CALM2 CALM3 TNNC2 HZGJ PPP3R1 PPP3R2
PVALB for paralogs About GeneDecksing
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Genomic Variantsfor PVALB gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 22 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for PVALB (37196728 - 37215523 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for PVALB 1 CNV : 4127
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing PVALB
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Disorders
/ Diseasesfor PVALB gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
PVALB for disorders About GeneDecksing
OMIM gene information: 168890
OMIM disorders : --20/72 diseases for PVALB (see all 72 ): About MalaCards dentatorubral-pallidoluysian atrophy xeroderma pigmentosum, group a neuronal ceroid-lipofuscinoses supranuclear palsy amyotrophic lateral sclerosis transient cerebral ischemia amyotrophic lateral sclerosis (als) xeroderma pigmentosum fetal alcohol syndrome focal cortical dysplasia progressive supranuclear palsy renal clear cell carcinoma diastolic heart failure temporal lobe epilepsy lateral sclerosis multiple system atrophy duchenne muscular dystrophy muscular dystrophy malignant pleural mesothelioma chromophobe renal cell carcinoma 7 diseases from the University of Copenhagen DISEASES database for PVALB :Schizophrenia Neurodegenerative disease Brain disease Hypersensitivity reaction type I disease Tetanus Oxyphilic adenoma Renal oncocytoma 10/57 Novoseek disease relationships for PVALB gene (see all 57 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
oncocytoma
63.7
13
16927643 (6), 11337362 (1), 14695146 (1), 16166433 (1) (see all 7 )
epilepsy temporal lobe
54.9
3
1865007 (1), 9329455 (1), 16822257 (1)
schizophrenia
48
18
11532725 (2), 12589379 (2), 15555777 (1), 11955958 (1) (see all 16 )
epilepsy
47
10
17535552 (1), 8064311 (1), 18562329 (1), 17267178 (1) (see all 7 )
fetal alcohol syndrome
39.9
2
19251116 (1)
neurodegeneration
39.1
2
10448425 (1), 15043712 (1)
allergy
38.2
7
15696099 (1), 19398906 (1), 12783765 (1), 11971005 (1) (see all 7 )
carcinoma renal cell
35.5
11
15286660 (4), 11504835 (3), 16927643 (1), 16512599 (1)
gliosis
35.3
1
17485991 (1)
neurofibrillary tangles
34.9
2
1717900 (2)
Export disorders for PVALB gene to outside databases
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Publicationsfor PVALB gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for PVALB gene integrated from 9 sources (see top 10 ): (articles sorted by number of sources associating them with PVALB) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence of human chromosome 22. (PubMed id 10591208) 1 , 2 , 3 Dunham I....O'Brien K.P. (1999) Electrospray ionization mass spectrometry: analysis of the Ca2+- binding properties of human recombinant alpha-parvalbumin and nine mutant proteins. (PubMed id 10036163) 1 , 2 , 9 Troxler H.... Heizmann C.W. (1999) Human alpha and beta parvalbumins. Structure and tissue-specific expression. (PubMed id 8354278) 1 , 2 , 9 Foehr U.G.... Heizmann C.W. (1993) The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. (PubMed id 1559707) 1 , 3, 9 Ritzler J.M....Berchtold M.W. (1992) A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802) 1 , 2 Collins J.E.... Dunham I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Parvalbumin genes from human and rat are identical in intron/exon organization and contain highly homologous regulatory elements and coding sequences. (PubMed id 2614829) 1 , 2 Berchtold M.W. (1989) Evaluating PVALB as a candidate gene for SLC12A3-nega tive cases of Gitelman's syndrome. (PubMed id 18469313) 1 , 9 Riveira-Munoz E....Dahan K. (2008) Distribution of parvalbumin and calretinin immunoreactive interneurons in motor cortex from multiple sclerosis post-mortem tissue. (PubMed id 18297277) 1 , 9 Clements R.J....Freeman E.J. (2008) Calbindin and parvalbumin immunoreactivity in the developing and adult human retina. (PubMed id 8804689) 1 , 9 Nag T.C. and Wadhwa S. (1996) Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus. (PubMed id 17850980) 1 , 9 Andrioli A....DeFelipe J. 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(1999) Early appearance of acetylcholinergic, serotoninergic , and peptidergic neurons and fibers in the developing human central nervous sy stem. (PubMed id 10402266) 9 Yew D.T. and Chan W.Y. (1999) Neuron loss and axon reorganization in the dentate gy rus of cats infected with the feline immunodeficiency virus. (PubMed id 10421868) 9 Mitchell T.W....Dudek F.E. (1999) Early development and composition of the human primordial plexiform layer: An immunohistochemical study. (PubMed id 10441754) 9 Zecevic N....MarA-n-Padilla M. (1999) The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease. (PubMed id 10486177) 9 Alexi T....Gluckman P.D. (1999) Regional and cellular localisation of GABA(A) receptor subunits in the human basal ganglia: An autoradiographic and immunohistochemical study. (PubMed id 10553118) 9 Waldvogel H.J....Faull R.L. (1999) Immunohistochemistry of neural markers for the study of the laminar architecture in celloidin sections from the human cerebral cortex. (PubMed id 10598866) 9 Miguel-Hidalgo J.J. and Rajkowska G. (1999) Seafood allergy: tropomyosins and beyond. (PubMed id 10637712) 9 Leung P.S....Chu K.H. (1999) Persistence of Cajal-Retzius cells in the adult human cerebral cortex. An immunohistochemical study. (PubMed id 10212810) 9 MartA-n R....de la Calle A. (1999) Immunohistochemical evaluation of the marbled state in childhood hypoxic encephalopathy. (PubMed id 10483783) 9 Araki S....Matsuyama H. (1999) Immunocytochemical characterization of quisqualic acid- and N-methyl-D-aspartate-induced excitotoxicity in the retina of chicks. (PubMed id 9520096) 9 Fischer A.J....Stell W.K. (1998) Dopamine innervation of a subclass of local circuit n eurons in monkey prefrontal cortex: ultrastructural analysis of tyrosine hydrox ylase and parvalbumin immunoreactive structures. 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(1998) Model of sarcomeric Ca2+ movements, including ATP Ca2 + binding and diffusion, during activation of frog skeletal muscle. (PubMed id 9725890) 9 Baylor S.M. and Hollingworth S. (1998) Chandelier cell axons are immunoreactive for GAT-1 in the human neocortex. (PubMed id 9512391) 9 DeFelipe J. and Gonzalez-Albo M.C. (1998) Comparison of mesencephalic free-floating tissue cult ure grafts and cell suspension grafts in the 6-hydroxydopamine-lesioned rat. (PubMed id 9551835) 9 Meyer M....Spenger C. (1998) Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons. (PubMed id 9507137) 9 Tallaksen-Greene S.J....Albin R.L. (1998) Chemical phenotype of calretinin interneurons in the human striatum. (PubMed id 9776132) 9 Cicchetti F....Parent A. (1998) Fluorescence detection of calcium-binding proteins with quinoline Ca-indicator quin2. (PubMed id 9398354) 9 Tatsumi R....Hattori A. (1997) The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease. (PubMed id 9184132) 9 Sampson V.L....Vickers J.C. (1997) The subthalamic nucleus in Parkinson's disease and pr ogressive supranuclear palsy. (PubMed id 9034366) 9 Hardman C.D....Morris J.G. (1997) Neurochemical architecture of the human striatum. (PubMed id 9214537) 9 Holt D.J....Saper C.B. (1997) Huntingtin immunoreactivity in the rat neostriatum: differential accumulation in projection and interneurons. (PubMed id 9168825) 9 Kosinski C.M....Standaert D.G. (1997) Disproportionate loss of CA4 parvalbumin-immunoreacti ve interneurons in patients with Ammon's horn sclerosis. (PubMed id 9291940) 9 Zhu Z.Q....Grossman R.G. (1997) Distribution of parvalbumin-immunoreactive neurons in brain correlates with hippocampal and temporal cortical pathology in Creutzfeldt-Jakob disease. (PubMed id 9329455) 9 Guentchev M....Budka H. (1997) Distribution of parvalbumin-, calretinin-, and calbindin-D28k-immunoreactive neurons and fibers in the human entorhinal cortex. (PubMed id 9364239) 9 Mikkonen M....PitkAonen A. (1997) GABAergic neuroaxonal dystrophy and other cytopathological alterations in feline Niemann-Pick disease type C. (PubMed id 9255392) 9 March P.A....Walkley S.U. (1997) Progressive supranuclear palsy affects both the subst antia nigra pars compacta and reticulata. (PubMed id 9126169) 9 Hardman C.D....Morris J.G. (1997) Loss of inhibitory synapses on the soma and axon init ial segment of pyramidal cells in human epileptic peritumoural neocortex: impli cations for epilepsy. (PubMed id 9288831) 9 Marco P....DeFelipe J. (1997) Neurofilament and calcium-binding proteins in the hum an cingulate cortex. (PubMed id 9259492) 9 Nimchinsky E.A....Hof P.R. (1997) Colocalization of parvalbumin, calretinin and calbindin D-28k in human cortical and subcortical visual structures. 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(1997) An optimal antigen retrieval method suitable for different antibodies on human brain tissue stored for several years in formaldehyde fixative. (PubMed id 9133585) 9 Evers P. and Uylings H.B. (1997) Differential co-localization of nicotinic acetylcholine receptor subunits with calcium-binding proteins in retinal ganglion cells. (PubMed id 9452220) 9 Araki C.M....Hamassaki-Britto D.E. (1997) Chronic focal neocortical epileptogenesis: does disinhibition play a role? (PubMed id 9250384) 9 Prince D.A....Parada I. (1997) Molecular and physiological diversity of cortical nonpyramidal cells. (PubMed id 9133407) 9 Cauli B....Rossier J. (1997) Expression of calbindin-D28K in motoneuron hybrid cel ls after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lat eral sclerosis IgG-mediated cytotoxicity. (PubMed id 8692898) 9 Ho B.K....Appel S.H. 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(1996) Cellular expression of ionotropic glutamate receptor subunits on specific striatal neuron types and its implication for striatal vulnerability in glutamate receptor-mediated excitotoxicity. (PubMed id 8809793) 9 Chen Q....Reiner A. (1996) Inhibitory neurons in the human epileptogenic temporal neocortex. An immunocytochemical study. (PubMed id 8813295) 9 Marco P....DeFelipe J. (1996) Identification of an S100A1/S100B target protein: phosphoglucomutase. (PubMed id 8894274) 9 Landar A....Zimmer D.B. (1996) Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study. (PubMed id 8916080) 9 Sorvari H....PitkAonen A. (1996) Differential abundance of glutamate transporter subty pes in amyotrophic lateral sclerosis (ALS)-vulnerable versus ALS-resistant brai n stem motor cell groups. (PubMed id 8934560) 9 Medina L....Reiner A. (1996) Cytoarchitectural distribution of calcium binding proteins in midbrain dopaminergic regions of rats and humans. (PubMed id 8789281) 9 McRitchie D.A....Halliday G.M. (1996) Hyperexcitability in a model of cortical maldevelopment. (PubMed id 8670677) 9 Jacobs K.M....Prince D.A. (1996) Expression of NMDAR2D glutamate receptor subunit mRNA in neurochemically identified interneurons in the rat neostriatum, neocortex and hippocampus. (PubMed id 8915584) 9 Standaert D.G....Young A.B. (1996) Decreased parvalbumin immunoreactivity in surviving Purkinje cells of patients with spinocerebellar ataxia-1. (PubMed id 8710087) 9 Vig P.J....Subramony S.H. (1996) Pre- and postnatal expression of amino acid neurotransmitters, calcium binding proteins, and nitric oxide synthase in the developing superior colliculus. (PubMed id 8979811) 9 Mize R.R....Scheiner C.A. (1996) Parvalbumin relaxes frog skeletal muscle when sarcopl asmic reticulum Ca(2+)-ATPase is inhibited. 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(1996) Local circuit neurons in the medial prefrontal cortex (areas 24a,b,c, 25 and 32) in the monkey: II. Quantitative areal and laminar distributions. (PubMed id 8821450) 9 Gabbott P.L. and Bacon S.J. (1996) Interaction of polyamines with the Ca(2+)-binding pro tein parvalbumin. (PubMed id 7607221) 9 Sudhakar K....Vanderkooi J.M. (1995) Neuronal injury following electrically induced status epilepticus with and without adenosine receptor antagonism. (PubMed id 7649219) 9 Young D. and Dragunow M. (1995) Increased intracellular calcium triggered by immune m echanisms in amyotrophic lateral sclerosis. (PubMed id 9021258) 9 Appel S.H....Stefani E. (1995-1996) Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. (PubMed id 7472396) 9 Du F....Schwarcz R. (1995) Identification of neuronal calcium sensor (NCS-1) possibly involved in the regulation of receptor phosphorylation. (PubMed id 8903951) 9 Nef S....Nef P. (1995) Neurochemical profile of glioneuronal lesions from patients with pharmacoresistant focal epilepsies. (PubMed id 7666058) 9 Wolf H.K....Wiestler O.D. (1995) [Study of conformation transitions in proteins by tryptophan fluorescence and phosphorescence at low temperatures] (PubMed id 7783738) 9 Permiakov E.A. and DeA-kis G.I.u. (1995) Parvalbumin is a marker of ALS-resistant motor neurons. (PubMed id 7766841) 9 Elliott J.L. and Snider W.D. (1995) Engineering magnesium selectivity in the helix-loop-helix calcium-binding motif. (PubMed id 7487056) 9 Reid R.E. and Procyshyn R.M. (1995) Cortical Lewy body-containing neurons are pyramidal c ells: laser confocal imaging of double-immunolabeled sections with anti-ubiquit in and SMI32. (PubMed id 7618438) 9 Wakabayashi K....Masliah E. (1995) Interconversion of the CD and EF sites in oncomodulin. Influence on the Eu3+ 7F0-->5D0 excitation spectrum. (PubMed id 7827057) 9 Kauffman J.F....Henzl M.T. (1995) Localization of AMPA-selective excitatory amino acid receptor subunits in identified populations of striatal neurons. (PubMed id 7969927) 9 Tallaksen-Greene S.J. and Albin R.L. (1994) Immunohistochemical localization of calcium-binding proteins in the human cutaneous sensory corpuscles. (PubMed id 8028786) 9 Del Valle M.E....Vega J.A. (1994) Delayed damage of striatal interneurons after cerebral ischemia in the gerbil. (PubMed id 7970228) 9 Araki T....Kato K. (1994) Immunochemical analysis of some proteins in cerebrospinal fluid and serum of patients with ischemic strokes. (PubMed id 7982025) 9 NiebrA^j-Dobosz I....Mossakowski M.J. (1994) Poor correlation between delayed neuronal death induc ed by transient forebrain ischemia, and immunoreactivity for parvalbumin and ca lbindin D-28k in developing gerbil hippocampus. (PubMed id 7941974) 9 Tortosa A. and Ferrer I. (1994) Parvalbumin and calbindin-D28k immunocytochemistry in human neocortical epileptic foci. 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(1993) Neurochemical development of the hippocampal region in the fetal rhesus monkey. I. Early appearance of peptides, calcium-binding proteins, DARPP-32, and monoamine innervation in the entorhinal cortex during the first half of gestation (E47 to E90). (PubMed id 8353610) 9 Berger B....Goldman-Rakic P.S. (1993) Chromogranin A, a soluble synaptic vesicle protein, is found in cortical neurons other than previously defined peptidergic neurons in the human neocortex. (PubMed id 8448675) 9 Adams L.A....Munoz D.G. (1993) The Leydig cell of the human testis--a new member of the diffuse neuroendocrine system. (PubMed id 8472301) 9 Davidoff M.S....Holstein A.F. (1993) Distribution, morphological features, and synaptic connections of parvalbumin- and calbindin D28k-immunoreactive neurons in the human hippocampal formation. (PubMed id 8276998) 9 Seress L....Freund T.F. (1993) Structural fluctuations in proteins revealed by time- resolved fluorescence spectroscopy. (PubMed id 16121443) 9 Ferreira S.T. (1993) Association of efferent neurons to the compartmental architecture of the superior colliculus. (PubMed id 1438296) 9 Illing R.B. (1992) Abnormal local-circuit neurons in epilepsia partialis continua associated with focal cortical dysplasia. (PubMed id 1636380) 9 Ferrer I....AlcA!ntara S. (1992) Relative sparing of GABAergic interneurons in the str iatum of gerbils with ischemia-induced lesions. (PubMed id 1542438) 9 Gonzales C....Chesselet M.F. (1992) Calcium-binding proteins in the nervous system. (PubMed id 1384200) 9 Baimbridge K.G....Rogers J.H. (1992) Chronic deafferentation in monkeys differentially affects nociceptive and nonnociceptive pathways distinguished by specific calcium-binding proteins and down-regulates gamma-aminobutyric acid type A receptors at thalamic levels. (PubMed id 1313562) 9 Rausell E....Jones E.G. (1992) The intracisternal A particle derived solo LTR promot er of the rat oncomodulin gene is not present in the mouse gene. (PubMed id 1468649) 9 Banville D....Boie Y. (1992) Organization and plasticity of GABA neurons and recep tors in monkey visual cortex. (PubMed id 1321463) 9 Hendry S. and Carder R.K. (1992) Postnatal development of parvalbumin immunoreactivity in axon terminals of basket and chandelier neurons in monkey neocortex. (PubMed id 1589590) 9 Akil M. and Lewis D.A. (1992) Calcium-binding proteins: an overview. (PubMed id 1864864) 9 Weinman S. (1991) Parvalbumin- and calbindin D28k-immunoreactive neurons in the hippocampal formation of the macaque monkey. (PubMed id 1761752) 9 Seress L....Freund T.F. (1991) Calcium-binding protein (calbindin-D28K) and parvalbumin immunocytochemistry in the normal and epileptic human hippocampus. (PubMed id 1865007) 9 Sloviter R.S....Laxer K.D. (1991) Parvalbumin- and calbindin-containing neurons in the monkey medial geniculate complex: differential distribution and cortical layer specific projections. (PubMed id 2039948) 9 Hashikawa T....Jones E.G. (1991) Sensitive enzyme immunoassay for human 28 kDa calbind in-D. (PubMed id 1756591) 9 Zhu Y.Y....Kato K. (1991) Fourier transform infrared spectroscopic studies of C a(2+)-binding proteins. (PubMed id 1911755) 9 Jackson M....Chapman D. (1991) Morphological taxonomy of the neurons of the primate striatum. (PubMed id 1722488) 9 Yelnik J....TandAc D. (1991) Decline of myoplasmic Ca2+, recovery of calcium release and sarcoplasmic Ca2+ pump properties in frog skeletal muscle. (PubMed id 1667802) 9 Klein M.G....Schneider M.F. (1991) Binding shift assay of parvalbumin, calmodulin and ca rbonic anhydrase by high-performance capillary electrophoresis. (PubMed id 1908870) 9 Kajiwara H....Oono K. (1991) Parvalbumin-immunoreactive neurons in the neocortex a re resistant to degeneration in Alzheimer's disease. (PubMed id 2061713) 9 Hof P.R....Morrison J.H. (1991) Parvalbumin-immunoreactive neurons in the human centr al nervous system are decreased in Alzheimer's disease. (PubMed id 2028743) 9 Satoh J....Tateishi J. (1991) N-terminal sequence analysis of N alpha-acetylated proteins after unblocking with N-acylaminoacyl-peptide hydrolase. (PubMed id 1807161) 9 Krishna R.G....Wold F. (1991) Calcium- and magnesium-binding properties of oncomodulin. Direct binding studies and microcalorimetry. (PubMed id 2108959) 9 Cox J.A....MacManus J.P. (1990) Comparison of metal ion-induced conformational changes in parvalbumin and oncomodulin as probed by the intrinsic fluorescence of tryptophan 102. (PubMed id 2365679) 9 Hutnik C.M....Szabo A.G. (1990) Calcium-binding proteins as markers for subpopulation s of GABAergic neurons in monkey striate cortex. (PubMed id 2170466) 9 Van Brederode J.F....Hendrickson A.E. (1990) Eu3+ luminescence studies of oncomodulin. The origin of the pH-dependent behavior. (PubMed id 2351666) 9 Trevino C.L....Henzl M.T. (1990) Evolution of EF-hand calcium-modulated proteins. I. Relationships based on amino acid sequences. (PubMed id 2115931) 9 Moncrief N.D....Goodman M. (1990) Cajal-Retzius neurons in developing monkey neocortex show immunoreactivity for calcium binding proteins. (PubMed id 2358829) 9 Huntley G.W. and Jones E.G. (1990) Ca2(+)-dependent mobility shift of parvalbumin in one - and two-dimensional gel-electrophoresis. (PubMed id 2112827) 9 Gregersen H.J....Celio M.R. (1990) A joint 2D NMR and theoretical investigation of Ca2+ binding loops III and IV of calmodulin. (PubMed id 2360994) 9 Gresh N....Lallemand J.Y. (1990)
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About This Section Patent Information for PVALB gene: Search GeneIP for patents involving PVALB GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor PVALB gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
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OriGene Antibodies for PVALB OriGene shRNA RFP for PVALB OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for PVALB OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for PVALB OriGene Protein Over-expression Lysate for PVALB Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for PVALB Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PVALB OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PVALB Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for PVALB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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