PUSL1 Gene
protein-coding GIFtS: 46
GCID: GC01P001233
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pseudouridylate synthase-like 1
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Aliases
for PUSL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pseudouridylate Synthase-Like 11 2 | | TRNA Pseudouridylate Synthase-Like 12 3 | | TRNA-Uridine Isomerase-Like 12 3 | | FLJ908111 | | TRNA Pseudouridine Synthase-Like 12 | | EC 5.4.99.-3 |
Export aliases for PUSL1 gene to outside databasesPrevious GC identifers: GC01P001283 GC01P000515 |
Summaries
for PUSL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PUSL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PUSL1 gene promoter:
SRF Egr-3 HTF NRSF form 1 NRSF form 2 Evi-1 E47 HEN1 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for PUSL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PUSL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33PUSL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P001233: view genomic region
(about GC identifiers)
Start:
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1,243,947 bp from pter |
End:
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1,247,057 bp from pter |
Size:
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3,111 bases |
Orientation:
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plus strand |
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Proteins
for PUSL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PUSL1_HUMAN, Q8N0Z8 (See
protein sequence)Recommended Name: tRNA pseudouridine synthase-like 1 Size: 303 amino acids; 33233 Da
Secondary accessions: B4DP76 Q5TA41Alternative splicing: 2 isoforms: Q8N0Z8-1 Q8N0Z8-2 Explore the universe of human proteins at neXtProt for PUSL1: NX_Q8N0Z8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N0Z8
PUSL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_699170.1
ENSEMBL proteins: ENSP00000368318 ENSP00000462968
Human Recombinant Protein Products for PUSL1:
PUSL1 Antibody Products:
Assay Products for PUSL1: |
Protein
Domains /
Families
for PUSL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PUSL1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N0Z8ProtoNet protein and cluster: Q8N0Z8 1 Blocks protein family: IPB001406 tRNA pseudouridine synthase
UniProtKB/Swiss-Prot: PUSL1_HUMAN, Q8N0Z8Similarity: Belongs to the tRNA pseudouridine synthase TruA family |
Function
for PUSL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PUSL1_HUMAN, Q8N0Z8Catalytic activity: tRNA uridine = tRNA pseudouridine Enzyme Number (IUBMB): EC 5.4.99.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003723 | RNA binding |
IEA | -- | | GO:0009982 | pseudouridine synthase activity |
IEA | -- |
PUSL1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for PUSL1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PUSL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PUSL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PUSL1 (NM_153339) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PUSL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUSL1 |
|
Pathways & Interactions
for PUSL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PUSL1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/231 Interacting proteins for PUSL1 (Q8N0Z82, 3 ENSP000003683184) via UniProtKB, MINT, STRING, and/or I2D (see all 231)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001522 | pseudouridine synthesis |
IEA | -- | | GO:0008033 | tRNA processing |
IEA | -- |
PUSL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PUSL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PUSL1
2 HMDB Compounds for PUSL1 About this table
Search CenterWatch for drugs/clinical trials and news about PUSL1
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Transcripts
for PUSL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PUSL1 gene: NM_153339.1 Unigene Cluster for PUSL1: Pseudouridylate synthase-like 1 Hs.400659 [show with all ESTs]Unigene Representative Sequence: AK0277215 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379031(uc001aed.3 uc010nyi.2) ENST00000470520 ENST00000463758
ENST00000467712 ENST00000493657(uc009vjx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PUSL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PUSL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PUSL1 (NM_153339) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PUSL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUSL1 |
Additional cDNA sequence: AK027721.1 AK075292.1 AK298218.1 BC034304.1 11 DOTS entries: DT.455178 DT.100862238 DT.100862241 DT.121344490 DT.95164263 DT.100862222 DT.100862236 DT.100862223 DT.95163238 DT.97855416 DT.100862242 24/52 AceView cDNA sequences (see all 52): CF131129 BC034304 BM925999 BG740556 BE549253 AK075292 BM915585 CR604312 BE264807 NM_153339 BI833278 BG767694 AI954969 AA069752 AA644009 AI954501 BV178533 AW510920 AW593941 BQ013269 AA922106 AW410660 CA421679 CB241496
GeneLoc Exon Structure
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Expression
for PUSL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PUSL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACACCAAGA
About this image
See PUSL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PUSL1
SOURCE GeneReport for Unigene cluster: Hs.400659
SABiosciences Custom PCR Arrays for PUSL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PUSL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PUSL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PUSL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUSL1 |
Orthologs
for PUSL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for PUSL1 gene from 8/22 species (see all 22) About this table
ENSEMBL Gene Tree for PUSL1 (if available)
TreeFam Gene Tree for PUSL1 (if available) |
Paralogs
for PUSL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PUSL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PUSL1 (1243947 - 1247057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PUSL1
3 CNVs: 0001 3275 30362 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PUSL1 |
|
Disorders
/ Diseases
for PUSL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PUSL1 for disorders About GeneDecksing
3  diseases for PUSL1: About MalaCardspneumonia tuberculosis mycobacterium tuberculosis
Export disorders for PUSL1 gene to outside databases
|
Publications
for PUSL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PUSL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PUSL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
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External Searches for PUSL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PUSL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PUSL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PUSL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PUSL1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for PUSL1 gene:
Search GeneIP for patents involving PUSL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PUSL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PUSL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PUSL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PUSL1 | | | OriGene Protein Over-expression Lysate for PUSL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PUSL1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PUSL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PUSL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PUSL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PUSL1 | | OriGene Custom Protein Services for PUSL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PUSL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PUSL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PUSL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PUSL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUSL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PUSL1 |
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| | | | Search Tocris compounds for PUSL1 |
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 | | | PUSL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for PUSL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUSL1 |
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