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Aliases for PUSL1 Gene

Aliases for PUSL1 Gene

  • Pseudouridylate Synthase-Like 1 2 3 5
  • TRNA Pseudouridylate Synthase-Like 1 4
  • TRNA-Uridine Isomerase-Like 1 4
  • EC 5.4.99.- 4

External Ids for PUSL1 Gene

Previous GeneCards Identifiers for PUSL1 Gene

  • GC01P001283
  • GC01P001233
  • GC01P000515

Summaries for PUSL1 Gene

GeneCards Summary for PUSL1 Gene

PUSL1 (Pseudouridylate Synthase-Like 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity.

Additional gene information for PUSL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PUSL1 Gene

Genomics for PUSL1 Gene

Regulatory Elements for PUSL1 Gene

Enhancers for PUSL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H001888 1.6 Ensembl ENCODE dbSUPER 20.8 +584.4 584443 9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 ATAD3B LOC105378949 CCNL2 LOC100288379 INTS11 ENSG00000240731 PUSL1 LOC100129381 RER1 CALML6
GH01H000998 1.4 ENCODE dbSUPER 22 -307.9 -307928 3 MLX FEZF1 DMAP1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 INTS11 WASH7P ATAD3B ENSG00000240731 ENSG00000230092 CCNL2 CDK11A SLC35E2 LOC100288379 LOC100129381
GH01H001373 1.2 ENCODE 21.2 +66.6 66557 3 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ENSG00000230092 CDK11A ATAD3B LOC100288379 CCNL2 INTS11 ENSG00000237094 SDF4 ENSG00000240731 LOC100288069
GH01H000957 1.1 ENCODE 21 -348.8 -348823 4 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 SP3 SP5 ENSG00000230092 NOC2L ATAD3B UBE2J2 CDK11A WASH7P PUSL1 ENSG00000237094 LOC100288069 KLHL17
GH01H002253 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +947.8 947825 6 PKNOX1 ATF1 ARNT BRCA1 ZNF2 ETS1 TCF12 GLIS2 CBX5 FOS ATAD3B CCNL2 ENSG00000240731 INTS11 CDK11A UBE2J2 RER1 CDK11B SLC35E2 LOC100288379
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PUSL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PUSL1 Gene

Chromosome:
1
Start:
1,308,567 bp from pter
End:
1,311,677 bp from pter
Size:
3,111 bases
Orientation:
Plus strand

Genomic View for PUSL1 Gene

Genes around PUSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PUSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PUSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PUSL1 Gene

Proteins for PUSL1 Gene

  • Protein details for PUSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z8-PUSL1_HUMAN
    Recommended name:
    tRNA pseudouridine synthase-like 1
    Protein Accession:
    Q8N0Z8
    Secondary Accessions:
    • B4DP76
    • Q5TA41

    Protein attributes for PUSL1 Gene

    Size:
    303 amino acids
    Molecular mass:
    33233 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PUSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PUSL1 Gene

Post-translational modifications for PUSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PUSL1 Gene

No data available for DME Specific Peptides for PUSL1 Gene

Domains & Families for PUSL1 Gene

Gene Families for PUSL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PUSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Z8

UniProtKB/Swiss-Prot:

PUSL1_HUMAN :
  • Belongs to the tRNA pseudouridine synthase TruA family.
Family:
  • Belongs to the tRNA pseudouridine synthase TruA family.
genes like me logo Genes that share domains with PUSL1: view

Function for PUSL1 Gene

Molecular function for PUSL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
tRNA uridine = tRNA pseudouridine.

Enzyme Numbers (IUBMB) for PUSL1 Gene

Gene Ontology (GO) - Molecular Function for PUSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0009982 pseudouridine synthase activity IEA,IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PUSL1: view

Phenotypes for PUSL1 Gene

genes like me logo Genes that share phenotypes with PUSL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PUSL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PUSL1 Gene

Localization for PUSL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PUSL1 gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PUSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with PUSL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PUSL1 Gene

Pathways & Interactions for PUSL1 Gene

SuperPathways for PUSL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PUSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0009451 RNA modification IEA --
GO:0031119 tRNA pseudouridine synthesis IBA --
genes like me logo Genes that share ontologies with PUSL1: view

No data available for Pathways by source and SIGNOR curated interactions for PUSL1 Gene

Drugs & Compounds for PUSL1 Gene

(1) Drugs for PUSL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine Experimental Pharma 0

(1) Additional Compounds for PUSL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
1445-07-4
genes like me logo Genes that share compounds with PUSL1: view

Transcripts for PUSL1 Gene

Unigene Clusters for PUSL1 Gene

Pseudouridylate synthase-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PUSL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PUSL1 Gene

No ASD Table

Relevant External Links for PUSL1 Gene

GeneLoc Exon Structure for
PUSL1
ECgene alternative splicing isoforms for
PUSL1

Expression for PUSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PUSL1 Gene

Protein differential expression in normal tissues from HIPED for PUSL1 Gene

This gene is overexpressed in Lung (41.1), Retina (8.6), and Testis (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PUSL1 Gene



Protein tissue co-expression partners for PUSL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PUSL1 Gene:

PUSL1

SOURCE GeneReport for Unigene cluster for PUSL1 Gene:

Hs.400659

Evidence on tissue expression from TISSUES for PUSL1 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with PUSL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PUSL1 Gene

Orthologs for PUSL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PUSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PUSL1 33 34
  • 99.19 (n)
cow
(Bos Taurus)
Mammalia PUSL1 33 34
  • 82.81 (n)
mouse
(Mus musculus)
Mammalia Pusl1 33 16 34
  • 80.64 (n)
dog
(Canis familiaris)
Mammalia PUSL1 33 34
  • 79.71 (n)
rat
(Rattus norvegicus)
Mammalia Pusl1 33
  • 79.3 (n)
chicken
(Gallus gallus)
Aves PUSL1 33 34
  • 55.99 (n)
lizard
(Anolis carolinensis)
Reptilia PUSL1 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pusl1 33
  • 56.56 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC555828 33
  • 53.01 (n)
PUSL1 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34140 33 34
  • 47.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009903 33
  • 46.43 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G09800 33
  • 44.4 (n)
rice
(Oryza sativa)
Liliopsida Os12g0194800 33
  • 46.31 (n)
Species where no ortholog for PUSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PUSL1 Gene

ENSEMBL:
Gene Tree for PUSL1 (if available)
TreeFam:
Gene Tree for PUSL1 (if available)

Paralogs for PUSL1 Gene

No data available for Paralogs for PUSL1 Gene

Variants for PUSL1 Gene

Sequence variations from dbSNP and Humsavar for PUSL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000013557 -- 1,307,957(+) GCCCC(C/G)CCTGT upstream-variant-2KB
rs1000473668 -- 1,309,380(+) CTCGA(A/G)GGGGA intron-variant, upstream-variant-2KB
rs1000778377 -- 1,308,812(+) GGACG(C/T)GGGTT intron-variant, upstream-variant-2KB
rs1001132193 -- 1,307,695(+) TCCCC(A/C)CCCCG intron-variant, upstream-variant-2KB
rs1001242875 -- 1,311,218(+) CAGCC(C/G)GTAGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PUSL1 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
dgv6n100 CNV gain+loss 25217958
dgv7n100 CNV loss 25217958
esv2758912 CNV loss 17122850
esv3890636 CNV loss 25118596
nsv1000169 CNV gain 25217958
nsv1009541 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160772 CNV duplication 26073780
nsv1160788 CNV deletion 26073780
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv544969 CNV loss 21841781
nsv544971 CNV loss 21841781
nsv950452 CNV deletion 24416366
nsv997291 CNV gain 25217958

Variation tolerance for PUSL1 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.38; 71.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PUSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PUSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PUSL1 Gene

Disorders for PUSL1 Gene

Relevant External Links for PUSL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PUSL1

No disorders were found for PUSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PUSL1 Gene

Publications for PUSL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for PUSL1 Gene

Sources for PUSL1 Gene

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