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Aliases for PUSL1 Gene

Aliases for PUSL1 Gene

  • Pseudouridylate Synthase-Like 1 2 3 5
  • TRNA Pseudouridylate Synthase-Like 1 4
  • TRNA-Uridine Isomerase-Like 1 4
  • EC 5.4.99.- 4

External Ids for PUSL1 Gene

Previous GeneCards Identifiers for PUSL1 Gene

  • GC01P001283
  • GC01P001233
  • GC01P000515

Summaries for PUSL1 Gene

GeneCards Summary for PUSL1 Gene

PUSL1 (Pseudouridylate Synthase-Like 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PUSL1 Gene

Genomics for PUSL1 Gene

Regulatory Elements for PUSL1 Gene

Enhancers for PUSL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PUSL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PUSL1 Gene

Chromosome:
1
Start:
1,308,567 bp from pter
End:
1,311,677 bp from pter
Size:
3,111 bases
Orientation:
Plus strand

Genomic View for PUSL1 Gene

Genes around PUSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PUSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PUSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PUSL1 Gene

Proteins for PUSL1 Gene

  • Protein details for PUSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z8-PUSL1_HUMAN
    Recommended name:
    tRNA pseudouridine synthase-like 1
    Protein Accession:
    Q8N0Z8
    Secondary Accessions:
    • B4DP76
    • Q5TA41

    Protein attributes for PUSL1 Gene

    Size:
    303 amino acids
    Molecular mass:
    33233 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PUSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PUSL1 Gene

Proteomics data for PUSL1 Gene at MOPED

Post-translational modifications for PUSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PUSL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PUSL1 Gene

Domains & Families for PUSL1 Gene

Suggested Antigen Peptide Sequences for PUSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Z8

UniProtKB/Swiss-Prot:

PUSL1_HUMAN :
  • Belongs to the tRNA pseudouridine synthase TruA family.
Family:
  • Belongs to the tRNA pseudouridine synthase TruA family.
genes like me logo Genes that share domains with PUSL1: view

No data available for Gene Families for PUSL1 Gene

Function for PUSL1 Gene

Molecular function for PUSL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
tRNA uridine = tRNA pseudouridine.

Enzyme Numbers (IUBMB) for PUSL1 Gene

Phenotypes for PUSL1 Gene

genes like me logo Genes that share phenotypes with PUSL1: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PUSL1 Gene

Localization for PUSL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PUSL1 Gene COMPARTMENTS Subcellular localization image for PUSL1 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PUSL1 Gene

Pathways & Interactions for PUSL1 Gene

SuperPathways for PUSL1 Gene

No Data Available

Interacting Proteins for PUSL1 Gene

Gene Ontology (GO) - Biological Process for PUSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009451 RNA modification IEA --
genes like me logo Genes that share ontologies with PUSL1: view

No data available for Pathways by source and SIGNOR curated interactions for PUSL1 Gene

Drugs & Compounds for PUSL1 Gene

(1) Drugs for PUSL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine Experimental Pharma 0

(1) Additional Compounds for PUSL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
1445-07-4
genes like me logo Genes that share compounds with PUSL1: view

Transcripts for PUSL1 Gene

Unigene Clusters for PUSL1 Gene

Pseudouridylate synthase-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PUSL1 Gene

No ASD Table

Relevant External Links for PUSL1 Gene

GeneLoc Exon Structure for
PUSL1
ECgene alternative splicing isoforms for
PUSL1

Expression for PUSL1 Gene

mRNA expression in normal human tissues for PUSL1 Gene

Protein differential expression in normal tissues from HIPED for PUSL1 Gene

This gene is overexpressed in Lung (41.1), Retina (8.6), and Testis (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PUSL1 Gene



SOURCE GeneReport for Unigene cluster for PUSL1 Gene Hs.400659

genes like me logo Genes that share expression patterns with PUSL1: view

Protein tissue co-expression partners for PUSL1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PUSL1 Gene

Orthologs for PUSL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PUSL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PUSL1 35
  • 82.81 (n)
  • 84.91 (a)
PUSL1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PUSL1 35
  • 79.71 (n)
  • 80.27 (a)
PUSL1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pusl1 35
  • 80.64 (n)
  • 80.41 (a)
Pusl1 16
Pusl1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PUSL1 35
  • 99.19 (n)
  • 99.02 (a)
PUSL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pusl1 35
  • 79.3 (n)
  • 86.29 (a)
chicken
(Gallus gallus)
Aves PUSL1 35
  • 55.99 (n)
  • 53.17 (a)
PUSL1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PUSL1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pusl1 35
  • 56.56 (n)
  • 53.79 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC555828 35
  • 53.01 (n)
  • 49.82 (a)
PUSL1 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009903 35
  • 46.43 (n)
  • 36.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34140 35
  • 47.78 (n)
  • 37.64 (a)
CG34140 36
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G09800 35
  • 44.4 (n)
  • 41.98 (a)
rice
(Oryza sativa)
Liliopsida Os12g0194800 35
  • 46.31 (n)
  • 45.04 (a)
Species with no ortholog for PUSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PUSL1 Gene

ENSEMBL:
Gene Tree for PUSL1 (if available)
TreeFam:
Gene Tree for PUSL1 (if available)

Paralogs for PUSL1 Gene

No data available for Paralogs for PUSL1 Gene

Variants for PUSL1 Gene

Sequence variations from dbSNP and Humsavar for PUSL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_034424 -
VAR_051869 -
rs2296474 -- 1,310,624(-) AAAAA(A/C/T)ACGTA intron-variant
rs11590283 -- 1,309,988(+) TGGAG(A/G)GGATT intron-variant
rs41285822 -- 1,309,939(+) AAGGT(A/G)AGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PUSL1 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv2n67 CNV Gain 20364138
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
nsv871329 CNV Gain 21882294
dgv25n71 CNV Loss 21882294
nsv870639 CNV Loss 21882294
nsv871666 CNV Gain+Loss 21882294
dgv28n71 CNV Gain 21882294
dgv8e1 CNV Complex 17122850
dgv29n71 CNV Loss 21882294
nsv870963 CNV Loss 21882294
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
dgv35n71 CNV Loss 21882294
dgv36n71 CNV Loss 21882294
dgv37n71 CNV Loss 21882294
nsv870491 CNV Loss 21882294
dgv38n71 CNV Loss 21882294

Variation tolerance for PUSL1 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.38; 71.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PUSL1 Gene

Disorders for PUSL1 Gene

Relevant External Links for PUSL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PUSL1

No disorders were found for PUSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PUSL1 Gene

Publications for PUSL1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3

Products for PUSL1 Gene

Sources for PUSL1 Gene

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