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Aliases for PUS7 Gene

Aliases for PUS7 Gene

  • Pseudouridylate Synthase 7 (Putative) 2 3 5
  • Pseudouridylate Synthase 7 Homolog (S. Cerevisiae) 2
  • EC 5.4.99.- 4
  • KIAA1897 4

External Ids for PUS7 Gene

Previous GeneCards Identifiers for PUS7 Gene

  • GC07M104884
  • GC07M105080
  • GC07M099455

Summaries for PUS7 Gene

GeneCards Summary for PUS7 Gene

PUS7 (Pseudouridylate Synthase 7 (Putative)) is a Protein Coding gene. Among its related pathways are tRNA processing and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PUS7L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PUS7 Gene

Genomics for PUS7 Gene

Regulatory Elements for PUS7 Gene

Enhancers for PUS7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F105486 1.1 Ensembl ENCODE 21.7 +34.3 34329 2.1 HDAC1 PKNOX1 ARNT RAD21 CHAMP1 GATA2 FOS ZNF654 REST NR2F2 PUS7 SRPK2 LOC100131785 GC07P105482
GH07F104976 1.8 FANTOM5 Ensembl ENCODE 13.2 +540.2 540167 11.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 KMT2E PUS7 KMT2E-AS1 LINC01004 EIF4BP6 RINT1 RWDD4P1 SRPK2 LOC101927902 GC07P104969
GH07F105492 1 Ensembl ENCODE 22.6 +27.1 27080 4.5 CTCF ATF1 PKNOX1 CREB3L1 JUN ZNF175 FOSL1 POLR2A FOS MAFK PUS7 SRPK2 GC07P105482
GH07F105531 1.1 ENCODE 19.6 -10.3 -10283 2.8 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 LOC100131785 PUS7 RINT1 EIF4BP6 RWDD4P1 ENSG00000272604 GC07P105567
GH07F106369 1.6 FANTOM5 Ensembl ENCODE 10.5 -847.3 -847334 0.4 ATF1 PKNOX1 SIN3A ZNF2 ZNF143 ZNF263 SP3 TSHZ1 REST ZNF264 ENSG00000272072 RINT1 HBP1 PUS7 NAMPT CDHR3 PIK3CG LARP1BP2 LOC105375438
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PUS7 on UCSC Golden Path with GeneCards custom track

Promoters for PUS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158638 866 2400 HDGF ATF1 CREB3L1 MLX ARID4B SIN3A FEZF1 GLI4 DMAP1 ZNF2

Genomic Location for PUS7 Gene

Chromosome:
7
Start:
105,439,661 bp from pter
End:
105,522,267 bp from pter
Size:
82,607 bases
Orientation:
Minus strand

Genomic View for PUS7 Gene

Genes around PUS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PUS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PUS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PUS7 Gene

Proteins for PUS7 Gene

  • Protein details for PUS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PZ0-PUS7_HUMAN
    Recommended name:
    Pseudouridylate synthase 7 homolog
    Protein Accession:
    Q96PZ0
    Secondary Accessions:
    • Q75MG4
    • Q9NX19

    Protein attributes for PUS7 Gene

    Size:
    661 amino acids
    Molecular mass:
    75035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91203.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PUS7 Gene

neXtProt entry for PUS7 Gene

Post-translational modifications for PUS7 Gene

  • Ubiquitination at Lys 278, Lys 318, and Lys 324
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PUS7 Gene

Domains & Families for PUS7 Gene

Suggested Antigen Peptide Sequences for PUS7 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PZ0

UniProtKB/Swiss-Prot:

PUS7_HUMAN :
  • Contains 1 TRUD domain.
  • Belongs to the pseudouridine synthase TruD family.
Domain:
  • Contains 1 TRUD domain.
Family:
  • Belongs to the pseudouridine synthase TruD family.
genes like me logo Genes that share domains with PUS7: view

No data available for Gene Families for PUS7 Gene

Function for PUS7 Gene

Molecular function for PUS7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
tRNA uridine = tRNA pseudouridine.

Enzyme Numbers (IUBMB) for PUS7 Gene

Gene Ontology (GO) - Molecular Function for PUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0009982 pseudouridine synthase activity IEA,IBA --
GO:0016853 isomerase activity IEA --
GO:0019899 enzyme binding IPI 23382074
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PUS7: view
genes like me logo Genes that share phenotypes with PUS7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PUS7 Gene

Localization for PUS7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PUS7 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for PUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with PUS7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PUS7 Gene

Pathways & Interactions for PUS7 Gene

genes like me logo Genes that share pathways with PUS7: view

Pathways by source for PUS7 Gene

Gene Ontology (GO) - Biological Process for PUS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis IBA --
GO:0008033 tRNA processing IEA --
GO:0009451 RNA modification IEA --
genes like me logo Genes that share ontologies with PUS7: view

No data available for SIGNOR curated interactions for PUS7 Gene

Drugs & Compounds for PUS7 Gene

(1) Additional Compounds for PUS7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
1445-07-4
genes like me logo Genes that share compounds with PUS7: view

Transcripts for PUS7 Gene

Unigene Clusters for PUS7 Gene

Pseudouridylate synthase 7 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PUS7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - -
SP2: -
SP3:

Relevant External Links for PUS7 Gene

GeneLoc Exon Structure for
PUS7
ECgene alternative splicing isoforms for
PUS7

Expression for PUS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PUS7 Gene

Protein differential expression in normal tissues from HIPED for PUS7 Gene

This gene is overexpressed in Breast (19.1) and Liver, secretome (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PUS7 Gene



Protein tissue co-expression partners for PUS7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PUS7 Gene:

PUS7

SOURCE GeneReport for Unigene cluster for PUS7 Gene:

Hs.520619
genes like me logo Genes that share expression patterns with PUS7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PUS7 Gene

Orthologs for PUS7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PUS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PUS7 34 35
  • 99.95 (n)
dog
(Canis familiaris)
Mammalia PUS7 34
  • 89.76 (n)
cow
(Bos Taurus)
Mammalia PUS7 34 35
  • 88.06 (n)
mouse
(Mus musculus)
Mammalia Pus7 34 16 35
  • 84.63 (n)
rat
(Rattus norvegicus)
Mammalia Pus7 34
  • 84.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PUS7 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PUS7 34 35
  • 78.09 (n)
lizard
(Anolis carolinensis)
Reptilia PUS7 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pus7 34
  • 73.03 (n)
Str.6483 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.28718 34
zebrafish
(Danio rerio)
Actinopterygii pus7 34 35
  • 66.61 (n)
Dr.14734 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005743 34
  • 47.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6745 34 35
  • 47.62 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11253g 34
  • 52.77 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR136C 34
  • 50.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUS7 34 35 37
  • 50.03 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G04820 34
  • 49.69 (n)
rice
(Oryza sativa)
Liliopsida Os05g0509300 34
  • 46.76 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1A4.09 34
  • 49.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2343 35
  • 38 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.101 34
Species where no ortholog for PUS7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PUS7 Gene

ENSEMBL:
Gene Tree for PUS7 (if available)
TreeFam:
Gene Tree for PUS7 (if available)

Paralogs for PUS7 Gene

Paralogs for PUS7 Gene

(1) SIMAP similar genes for PUS7 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PUS7 Gene

genes like me logo Genes that share paralogs with PUS7: view

Variants for PUS7 Gene

Sequence variations from dbSNP and Humsavar for PUS7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10234361 -- 105,513,435(+) ctctc(A/G)aatct intron-variant
rs10235921 -- 105,473,774(+) gtctt(C/G)aactc intron-variant
rs10243444 -- 105,475,284(+) gggtt(C/T)acgcc intron-variant
rs10243447 -- 105,475,286(+) gttca(C/T)gccat intron-variant
rs10243575 -- 105,475,395(+) ttagc(C/T)aggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PUS7 Gene

Variant ID Type Subtype PubMed ID
nsv8197 CNV gain 18304495
nsv8196 CNV gain 18304495
nsv608069 CNV gain 21841781
nsv464668 CNV gain 19166990
nsv1120163 OTHER inversion 24896259
nsv1117751 CNV deletion 24896259
nsv1114994 CNV deletion 24896259
nsv1029832 CNV gain 25217958
nsv1023564 CNV gain 25217958
esv3891174 CNV gain 25118596
esv3614426 CNV gain 21293372
esv3614424 CNV gain 21293372
esv3614423 CNV gain 21293372
esv3614417 CNV gain 21293372
esv3542220 CNV deletion 23714750
esv2759549 CNV gain 17122850
esv2734973 CNV deletion 23290073
dgv6547n100 CNV gain 25217958
dgv237e55 CNV gain 17911159

Variation tolerance for PUS7 Gene

Residual Variation Intolerance Score: 7.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PUS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PUS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PUS7 Gene

Disorders for PUS7 Gene

Relevant External Links for PUS7

Genetic Association Database (GAD)
PUS7
Human Genome Epidemiology (HuGE) Navigator
PUS7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PUS7

No disorders were found for PUS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PUS7 Gene

Publications for PUS7 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for PUS7 Gene

Sources for PUS7 Gene

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