Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PUS3 Gene

protein-coding GIFtS: 49
GCID: GC11M125763

pseudouridylate synthase 3

Explore 3 diseases affiliated with
PUS3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Pseudouridylate Synthase 3¹ ²		FKSG32¹
TRNA Pseudouridine Synthase 3² ³		2610020J05Rik²
TRNA Pseudouridylate Synthase 3² ³		TRNA Pseudouridine(38/39) Synthase²
TRNA-Uridine Isomerase 3² ³		EC 5.4.99.45³

External Ids:	HGNC: 25461¹	Entrez Gene: 83480²	Ensembl: ENSG00000110060⁷	UniProtKB: Q9BZE2³

Export aliases for PUS3 gene to outside databases

Previous GC identifers: GC11M125268 GC11M121705

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PUS3:

The protein encoded by this gene catalyzes the formation of tRNA pseudouridine from tRNA uridine at position 39 in the

anticodon stem and loop of transfer RNAs. Two transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: PUS3_HUMAN, Q9BZE2

Function: Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PUS3 gene promoter:
TBP AML1a Tal-1 Pax-6 Pax-2 Pax-2a GATA-2 E47 AREB6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PUS3 promoter sequence

Search SABiosciences Chromatin IP Primers for PUS3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PUS3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q24.2

PUS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PUS3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M125763: view genomic region (about GC identifiers)

Start:	125,763,380 bp from pter	End:	125,773,116 bp from pter
Size:	9,737 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PUS3_HUMAN, Q9BZE2 (See protein sequence)

Recommended Name: tRNA pseudouridine(38/39) synthase

Size: 481 amino acids; 55647 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: B2RAM0 Q96D17 Q96J23 Q96NB4

Explore the universe of human proteins at neXtProt for PUS3: NX_Q9BZE2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BZE2

PUS3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001258914.1 NP_112597.3

ENSEMBL proteins:

ENSP00000432386 ENSP00000432272 ENSP00000437077 ENSP00000227474

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PUS3 OriGene Protein Over-expression Lysate: PUS3 OriGene Custom Protein Services for PUS3
	GenScript Custom Purified and Recombinant Proteins Services for PUS3
	Novus Biologicals PUS3 Protein Novus Biologicals PUS3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PUS3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

PUS3 for ontologies About GeneDecksing

PUS3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for PUS3
	GenScript Custom Superior Antibodies Services for PUS3
	Novus Biologicals PUS3 Antibody
	Search for Antibodies for PUS3 at Abcam
	Uscn Antibodies for PUS3
	ThermoFisher Antibodies for PUS3

Assay Products for PUS3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PUS3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PUS3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PUS3 for domains About GeneDecksing

5 InterPro domains/families:

IPR020097 PsdUridine_synth_TruA_a/b_dom

IPR020103 PsdUridine_synth_cat_dom

IPR020094 PsdUridine_synth_TruA_N

IPR020095 PsdUridine_synth_TruA_C

IPR001406 PsdUridine_synth_TruA

Graphical View of Domain Structure for InterPro Entry Q9BZE2

ProtoNet protein and cluster: Q9BZE2

1 Blocks protein family: IPB001406 tRNA pseudouridine synthase

UniProtKB/Swiss-Prot: PUS3_HUMAN, Q9BZE2

Similarity: Belongs to the tRNA pseudouridine synthase TruA family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PUS3_HUMAN, Q9BZE2

Function: Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)

Catalytic activity: tRNA uridine(38/39) = tRNA pseudouridine(38/39)

Enzyme Number (IUBMB): EC 5.4.99.45¹

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PUS3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate PUS3:
		hsa-miR-124 hsa-miR-506
		SwitchGear 3'UTR luciferase reporter plasmid: PUS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PUS3 (see all 7) OriGene shRNA RFP: PUS3 OriGene siRNA: PUS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PUS3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PUS3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PUS3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PUS3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PUS3 (NM_031307)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PUS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUS3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PUS3
		Search LifeMap BioReagents cell lines for PUS3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUS3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0009982	pseudouridine synthase activity	IEA	--

PUS3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PUS3:

Decreased viability of wild-ty

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PUS3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/144 Interacting proteins for PUS3 (Q9BZE2³ ENSP00000227474⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 144)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0031119	tRNA pseudouridine synthesis	IEA	--

PUS3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PUS3

2 HMDB Compounds for PUS3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Pseudouridine	5-(b-D-Ribofuranosyl)uracil (see all 12)	1445-07-4	--
Uridine	1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione (see all 9)	58-96-8	--

Search CenterWatch for drugs/clinical trials and news about PUS3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PUS3 gene (2 alternative transcripts):

NM_001271985.1 NM_031307.3

Unigene Cluster for PUS3:

Pseudouridylate synthase 3

Hs.660922 [show with all ESTs]

Unigene Representative Sequence: NM_031307

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000530811 ENST00000534158 ENST00000529801 ENST00000227474(uc001qcy.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PUS3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate PUS3:
		hsa-miR-124 hsa-miR-506
		SwitchGear 3'UTR luciferase reporter plasmid: PUS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PUS3 (see all 7) OriGene shRNA RFP: PUS3 OriGene siRNA: PUS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PUS3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PUS3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PUS3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PUS3 (NM_031307)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PUS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUS3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PUS3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PUS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PUS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUS3

Additional cDNA sequence:

AF325689.1 AK055702.1 AK074218.1 AK314251.1 BC004822.1 BC013427.2

4 DOTS entries:

DT.410928 DT.100812546 DT.91887256 DT.95156177

24/57 AceView cDNA sequences (see all 57):

AA376153 BG113960 BM903885 BG421546 BF972366 AA988818 CA942585 NM_031307

BM459808 BU145971 AF325689 AA432136 BQ230942 BM759156 BX095434 AA127469

BU517204 AA608701 BM845153 AK055702 BX488578 AA594661 AW016543 AA431120

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PUS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAAGAAAC

About this image
See PUS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PUS3

SOURCE GeneReport for Unigene cluster: Hs.660922

SABiosciences Custom PCR Arrays for PUS3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PUS3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PUS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PUS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUS3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUS3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PUS3 gene from 9/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pus3^{1 , 5}	pseudouridine synthase 3^{1, 5}	86.93(n)¹ 86.16(a)¹		9 (20.32 cM)⁵ 67049¹ NM_023292.4¹ NP_075781.3¹ 35558595⁵
chicken (Gallus gallus)	Aves	PUS3¹	pseudouridylate synthase 3	68.52(n) 71.99(a)		419708 XM_417852.3 XP_417852.3
lizard (Anolis carolinensis)	Reptilia	PUS3⁶	--	63(a)	1 ↔ 1	GL343322.1(192421-195930)
zebrafish (Danio rerio)	Actinopterygii	pus3¹	pseudouridylate synthase 3	57.33(n) 54.89(a)		337487 NM_200067.1 NP_956361.1
fruit fly (Drosophila melanogaster)	Insecta	CG3045¹	CG3045	49.71(n) 45.19(a)		37531 NM_137802.3 NP_611646.1
worm (Caenorhabditis elegans)	Secernentea	tag-124¹	Protein TAG-124	50.73(n) 37.36(a)		174509 NM_063661.6 NP_496062.3
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	DEG1(YFL001W)⁴ DEG1¹	tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability less⁴ Deg1p¹	52.63(n)¹ 47.37(a)¹		6(147131-148459)⁴ 850550^{1, 4} NP_116655.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G34150¹	pseudouridine synthase-like protein	49.24(n) 43.47(a)		840314 NM_103138.2 NP_564438.1
rice (Oryza sativa)	Liliopsida	Os03g0381100¹	hypothetical protein	47.79(n) 41.84(a)		4332977 NM_001056774.2 NP_001050239.2

ENSEMBL Gene Tree for PUS3 (if available)
TreeFam Gene Tree for PUS3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs662715^1,2	C,F,H,	--	125762891(+)	`TTCTGC/ACTTAG`	3	--	int¹		32		MN NS EA NA WA CSA	3009
rs148936201^1,2		--	125762968(+)	`CAATAC/TCTCCT`	3	--	int¹		0	--	--	--	--
rs79101727^1,2		--	125762991(+)	`GCCTAC/TAGTCA`	3	--	int¹		1		CSA	2
rs200170983^1,2		--	125763182(+)	`TAAGA-/TTTAAGG`	3	--	int¹		0	--	--	--	--
rs201355869^1,2		--	125763184(+)	`AGATA-/TAGGTA`	3	--	int¹		0	--	--	--	--
rs148177516^1,2		--	125763186(+)	`GATAAG/TGTACT`	3	--	int¹		0	--	--	--	--
rs141975226^1,2		--	125763220(+)	`TTTGTG/TCCTGG`	3	--	int¹		0	--	--	--	--
rs150247955^1,2		--	125763391(+)	`CAGGAC/TTAGGC`	3	--	ut3¹ int¹		0	--	--	--	--
rs117947859^1,2	C,F,	--	125763452(+)	`TCTCCA/GTTTTA`	3	--	int¹ ut3¹		1		EA	120
rs191173560^1,2		--	125763470(+)	`TAATCA/GCTTAA`	3	--	int¹ ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PUS3 (125763380 - 125773116 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PUS3
1 CNV: 6905

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PUS3

DNA2.0 Custom Variant and Variant Library Synthesis for PUS3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PUS3 for disorders About GeneDecksing

3 diseases for PUS3: About MalaCards

sideroblastic anemia anemia malaria

1 disease from the University of Copenhagen DISEASES database for PUS3:

Sideroblastic anemia

Export disorders for PUS3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PUS3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PUS3)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA. (PubMed id 11027153)^{1, 9} Chen J. and Patton J.R. (2000)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
Transcriptome analysis of human gastric cancer. (PubMed id 16341674)¹ Oh J.H....Kim N.S. (2005)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83480	HGNC: 25461	AceView: PUS3	Ensembl:ENSG00000110060	euGenes: HUgn83480
ECgene: PUS3	H-InvDB: PUS3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PUS3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PUS3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PUS3 gene:
Search GeneIP for patents involving PUS3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for PUS3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PUS3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PUS3
	OriGene Protein Over-expression Lysate for PUS3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for PUS3		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PUS3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PUS3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for PUS3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PUS3		OriGene Custom Protein Services for PUS3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PUS3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PUS3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PUS3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PUS3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PUS3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PUS3

	GenScript Custom Purified and Recombinant Proteins Services for PUS3		GenScript cDNA clones with any tag delivered in your preferred vector for PUS3
	GenScript Custom Assay Services for PUS3		GenScript Custom Superior Antibodies Services for PUS3
	GenScript Custom overexpressing Cell Line Services for PUS3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PUS3 promoter
	Search Chromatin IP Primers for PUS3
	RT² qPCR Primer Assay in human, mouse, rat PUS3
	Search GNC Networks for PUS3
	SABiosciences Custom PCR Arrays for PUS3

Search Tocris compounds for PUS3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PUS3 antibodies
	PUS3 proteins
	PUS3 lysates

	Search for Antibodies for PUS3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for PUS3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

PUS3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for PUS3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PUS3

	SwitchGear 3'UTR luciferase reporter plasmids for PUS3
	SwitchGear Promoter luciferase reporter plasmids for PUS3

ThermoFisher Antibodies for PUS3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PUS3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PUS3 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

PUS3 Gene

pseudouridylate synthase 3

Aliases
for PUS3 gene

Summaries
for PUS3 gene

Genomic Views
for PUS3 gene

Proteins
for PUS3 gene

Protein Domains /
Families
for PUS3 gene

Function
for PUS3 gene

Pathways & Interactions
for PUS3 gene

Drugs & Compounds
for PUS3 gene

Transcripts
for PUS3 gene

Expression
for PUS3 gene

Orthologs
for PUS3 gene

Paralogs
for PUS3 gene

Genomic Variants
for PUS3 gene

Disorders / Diseases
for PUS3 gene

Publications
for PUS3 gene

External Searches for PUS3 gene

Genome Databases showing PUS3 gene

Other Databases showing PUS3 gene

Specialized Databases showing PUS3 gene

Intellectual Property
for PUS3 gene

Products
for PUS3 gene

View Random Gene

Advanced Search

Export list of displayed genes

PUS3 Gene

pseudouridylate synthase 3

Aliasesfor PUS3 gene

Summariesfor PUS3 gene

Genomic Viewsfor PUS3 gene

Proteinsfor PUS3 gene

Protein Domains /Familiesfor PUS3 gene

Functionfor PUS3 gene

Pathways & Interactionsfor PUS3 gene

Drugs & Compoundsfor PUS3 gene

Transcriptsfor PUS3 gene

Expression for PUS3 gene

Orthologsfor PUS3 gene

Paralogsfor PUS3 gene

Genomic Variantsfor PUS3 gene

Disorders / Diseasesfor PUS3 gene

Publicationsfor PUS3 gene

External Searches for PUS3 gene

Genome Databases showing PUS3 gene

Other Databases showing PUS3 gene

Specialized Databases showing PUS3 gene

Intellectual Propertyfor PUS3 gene

Productsfor PUS3 gene

View Random Gene

Aliases
for PUS3 gene

Summaries
for PUS3 gene

Genomic Views
for PUS3 gene

Proteins
for PUS3 gene

Protein Domains /
Families
for PUS3 gene

Function
for PUS3 gene

Pathways & Interactions
for PUS3 gene

Drugs & Compounds
for PUS3 gene

Transcripts
for PUS3 gene

Expression
for PUS3 gene

Orthologs
for PUS3 gene

Paralogs
for PUS3 gene

Genomic Variants
for PUS3 gene

Disorders / Diseases
for PUS3 gene

Publications
for PUS3 gene

Intellectual Property
for PUS3 gene

Products
for PUS3 gene